SIMILAR PATTERNS OF AMINO ACIDS FOR 3FAL_C_REAC501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis)
PF03212
(Pertactin)
5 ALA A 387
ALA A 357
LEU A 383
ALA A 384
ILE A 310
None
1.02A 3falC-1dabA:
undetectable
3falC-1dabA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqu ISOCITRATE LYASE

(Aspergillus
nidulans)
PF00463
(ICL)
5 ILE A 166
ALA A 192
ALA A 191
LEU A  59
ALA A  56
None
0.94A 3falC-1dquA:
undetectable
3falC-1dquA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE


(Escherichia
coli)
PF00155
(Aminotran_1_2)
5 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
None
0.89A 3falC-1fc4A:
undetectable
3falC-1fc4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE


(Escherichia
coli)
PF01182
(Glucosamine_iso)
5 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
None
1.03A 3falC-1fs5A:
undetectable
3falC-1fs5A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE


([Clostridium]
symbiosum)
PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C)
5 ILE A 368
ALA A 370
LEU A 864
ALA A 865
ILE A 359
None
1.00A 3falC-1kblA:
undetectable
3falC-1kblA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4y ATP-DEPENDENT
PROTEASE HSLV


(Thermotoga
maritima)
PF00227
(Proteasome)
5 ILE A 122
ALA A  47
LEU A  94
ALA A  93
ILE A 103
None
1.03A 3falC-1m4yA:
undetectable
3falC-1m4yA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN


(Oligotropha
carboxidovorans)
PF00111
(Fer2)
PF01799
(Fer2_2)
5 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.96A 3falC-1n60A:
undetectable
3falC-1n60A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI


(Escherichia
coli)
PF01784
(NIF3)
5 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
None
0.99A 3falC-1nmoA:
undetectable
3falC-1nmoA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D


(Escherichia
coli)
PF00849
(PseudoU_synth_2)
5 ILE A 236
ALA A 173
LEU A 279
ALA A 278
ILE A 189
None
1.02A 3falC-1przA:
undetectable
3falC-1przA:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA


(Homo sapiens)
PF00104
(Hormone_recep)
10 ILE A 339
ALA A 342
ALA A 343
GLN A 346
PHE A 384
ARG A 387
LEU A 397
ALA A 398
ILE A 416
CYH A 503
MEI  A1001 (-3.8A)
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
None
MEI  A1001 (-4.0A)
0.66A 3falC-1uhlA:
29.6
3falC-1uhlA:
88.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukw ACYL-COA
DEHYDROGENASE


(Thermus
thermophilus)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 ILE A 117
ALA A 120
LEU A 150
ALA A 151
ILE A  55
None
0.93A 3falC-1ukwA:
undetectable
3falC-1ukwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori)
PF01264
(Chorismate_synt)
5 ALA A 139
ALA A 137
LEU A 341
ALA A 340
ILE A  83
None
1.05A 3falC-1umfA:
undetectable
3falC-1umfA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wve 4-CRESOL
DEHYDROGENASE
[HYDROXYLATING]
FLAVOPROTEIN SUBUNIT


(Pseudomonas
putida)
PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C)
5 GLN A  23
PHE A  25
LEU A  28
ALA A  27
ILE A 507
None
1.03A 3falC-1wveA:
undetectable
3falC-1wveA:
17.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata)
PF00104
(Hormone_recep)
10 ILE A 242
ALA A 245
ALA A 246
GLN A 249
PHE A 287
ARG A 290
LEU A 300
ALA A 301
ILE A 319
CYH A 406
9CR  A 201 ( 4.4A)
9CR  A 201 (-3.6A)
9CR  A 201 (-3.6A)
9CR  A 201 (-4.1A)
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
None
9CR  A 201 (-3.6A)
0.36A 3falC-1xiuA:
30.1
3falC-1xiuA:
81.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
10 ILE A 268
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
9CR  A 801 (-3.9A)
9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
9CR  A 801 (-4.7A)
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.5A)
9CR  A 801 ( 3.7A)
0.32A 3falC-1xlsA:
29.4
3falC-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfm FUMARASE

(Saccharomyces
cerevisiae)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
5 ILE A 391
ALA A 176
ALA A 177
GLN A 180
LEU A  70
None
1.05A 3falC-1yfmA:
undetectable
3falC-1yfmA:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR


(Bemisia tabaci)
PF00104
(Hormone_recep)
5 ILE U 303
ALA U 306
ALA U 307
LEU U 365
ALA U 362
None
0.85A 3falC-1z5xU:
22.0
3falC-1z5xU:
63.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
None
None
GOL  A3003 ( 3.8A)
None
None
0.91A 3falC-1zk7A:
undetectable
3falC-1zk7A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g39 ACETYL-COA HYDROLASE

(Pseudomonas
aeruginosa)
PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C)
5 ILE A  25
ALA A  22
ALA A  21
LEU A  49
ALA A  48
None
1.06A 3falC-2g39A:
undetectable
3falC-2g39A:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
6 PHE A  92
ARG A  95
LEU A 105
ALA A 106
ILE A 124
CYH A 211
None
0.84A 3falC-2gl8A:
28.1
3falC-2gl8A:
85.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D


(Escherichia
coli)
PF00849
(PseudoU_synth_2)
PF01479
(S4)
5 ILE A 236
ALA A 173
LEU A 279
ALA A 278
ILE A 189
None
1.02A 3falC-2istA:
undetectable
3falC-2istA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE


(Oxalobacter
formigenes)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ILE A 210
ALA A 207
ALA A 206
LEU A 337
ALA A 336
None
1.03A 3falC-2ji9A:
undetectable
3falC-2ji9A:
18.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)


(Tribolium
castaneum)
PF00104
(Hormone_recep)
5 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
None
0.74A 3falC-2nxxA:
24.6
3falC-2nxxA:
63.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6w PUTATIVE
GLYCOSYLTRANSFERASE
(MANNOSYLTRANSFERASE
) INVOLVED IN
GLYCOSYLATING THE
PBCV-1 MAJOR CAPSID
PROTEIN


(Paramecium
bursaria
Chlorella virus
1)
PF05637
(Glyco_transf_34)
5 ILE A  61
ALA A  64
ALA A  65
LEU A   9
ILE A 132
None
0.84A 3falC-2p6wA:
undetectable
3falC-2p6wA:
23.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis)
PF00104
(Hormone_recep)
5 PHE A 188
ARG A 191
ALA A 202
ILE A 220
CYH A 307
None
0.65A 3falC-2q60A:
27.6
3falC-2q60A:
72.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8w POKEWEED ANTIVIRAL
PROTEIN


(Phytolacca
acinosa)
PF00161
(RIP)
5 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
None
1.01A 3falC-2q8wA:
undetectable
3falC-2q8wA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb0 TELSAM DOMAIN -
LYSOZYME CHIMERA


(Escherichia
virus T4)
PF00959
(Phage_lysozyme)
PF02198
(SAM_PNT)
5 ALA B 222
PHE B 246
LEU B 226
ALA B 223
ILE B 171
None
1.02A 3falC-2qb0B:
undetectable
3falC-2qb0B:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F


(Enterococcus
faecium)
PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N)
5 ILE A  62
GLN A  57
PHE A  58
LEU A  59
ILE A 145
None
1.02A 3falC-2qr4A:
undetectable
3falC-2qr4A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA


(Escherichia
coli)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
5 ILE A  62
ALA A  66
ALA A  65
LEU A  84
ALA A  81
None
1.02A 3falC-2xaxA:
undetectable
3falC-2xaxA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE


(Thermococcus
kodakarensis)
PF00082
(Peptidase_S8)
PF04151
(PPC)
5 ILE A 368
ALA A 415
ALA A 416
LEU A 388
ALA A 387
None
0.98A 3falC-3afgA:
undetectable
3falC-3afgA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B


(Thermotoga
maritima)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
5 ILE B  11
GLN B  14
LEU B 196
ALA B 195
ILE B 119
None
0.98A 3falC-3al0B:
undetectable
3falC-3al0B:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE


(Mycobacterium
tuberculosis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 ALA A 104
ALA A 102
PHE A  31
LEU A  28
ALA A  29
None
1.05A 3falC-3ce6A:
undetectable
3falC-3ce6A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR


(Vibrio
parahaemolyticus)
PF13377
(Peripla_BP_3)
5 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  76
None
0.86A 3falC-3d8uA:
undetectable
3falC-3d8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR


(Vibrio
parahaemolyticus)
PF13377
(Peripla_BP_3)
5 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  77
None
1.04A 3falC-3d8uA:
undetectable
3falC-3d8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN


(Bordetella
pertussis)
PF01266
(DAO)
5 ILE A  10
ALA A 205
ALA A 204
LEU A 212
ALA A 209
FAD  A 500 (-4.5A)
FAD  A 500 (-3.6A)
None
FAD  A 500 ( 4.3A)
None
0.94A 3falC-3dmeA:
undetectable
3falC-3dmeA:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
10 ILE A 268
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
9CR  A7223 (-3.9A)
9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
9CR  A7223 (-4.6A)
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
9CR  A7223 ( 4.9A)
9CR  A7223 (-3.8A)
0.79A 3falC-3dzuA:
29.8
3falC-3dzuA:
51.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2


(Phytolacca
dioica)
PF00161
(RIP)
5 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
None
0.99A 3falC-3h5kA:
undetectable
3falC-3h5kA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7a SHORT CHAIN
DEHYDROGENASE


(Rhodopseudomonas
palustris)
PF00106
(adh_short)
5 ILE A  21
ALA A  22
ALA A  19
ALA A  34
ILE A 183
ILE  A  21 ( 0.6A)
ALA  A  22 ( 0.0A)
ALA  A  19 ( 0.0A)
ALA  A  34 ( 0.0A)
ILE  A 183 ( 0.7A)
1.03A 3falC-3h7aA:
undetectable
3falC-3h7aA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens)
PF00651
(BTB)
PF07707
(BACK)
5 ILE A  47
ALA A  50
ALA A  51
LEU B  20
ALA B  19
None
0.59A 3falC-3hveA:
undetectable
3falC-3hveA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens)
PF00651
(BTB)
PF07707
(BACK)
5 ILE B  47
ALA B  50
ALA B  51
LEU A  20
ALA A  19
None
0.66A 3falC-3hveB:
undetectable
3falC-3hveB:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE


(Ruegeria
pomeroyi)
PF03435
(Sacchrp_dh_NADP)
5 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
None
0.78A 3falC-3ic5A:
undetectable
3falC-3ic5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)


(Agrobacterium
fabrum)
PF13458
(Peripla_BP_6)
5 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
None
0.73A 3falC-3ipcA:
undetectable
3falC-3ipcA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
5 ILE A1994
ALA A1991
ALA A1990
LEU A1976
ALA A1979
None
1.05A 3falC-3jbzA:
undetectable
3falC-3jbzA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqy PUTATIVE
ISOCHORISMATASE
HYDROLASE


(Oleispira
antarctica)
PF00857
(Isochorismatase)
5 ALA A 146
ALA A  35
GLN A  38
ALA A 182
ILE A  77
None
1.04A 3falC-3lqyA:
undetectable
3falC-3lqyA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msu CITRATE SYNTHASE

(Francisella
tularensis)
PF00285
(Citrate_synt)
5 ALA A 175
ALA A 176
LEU A 388
ALA A 384
ILE A 218
None
0.96A 3falC-3msuA:
undetectable
3falC-3msuA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0m HIT FAMILY PROTEIN

(Mycolicibacterium
smegmatis)
PF01230
(HIT)
5 ILE A  67
ALA A  70
ALA A  71
LEU A 136
ALA A 135
None
0.56A 3falC-3o0mA:
undetectable
3falC-3o0mA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE


(Mycolicibacterium
smegmatis)
PF00202
(Aminotran_3)
5 ILE A 327
ALA A 331
ALA A 330
LEU A 298
ALA A 295
None
1.00A 3falC-3oksA:
undetectable
3falC-3oksA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr8 BASEPLATE ASSEMBLY
PROTEIN V


(Escherichia
virus P2)
PF04717
(Phage_base_V)
5 ILE A  69
ALA A  71
ALA A  79
ILE A  23
CYH A  33
None
1.05A 3falC-3qr8A:
undetectable
3falC-3qr8A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5w L-ORNITHINE
5-MONOOXYGENASE


(Pseudomonas
aeruginosa)
PF13434
(K_oxygenase)
5 ILE A 419
ALA A 416
LEU A  25
ALA A  24
ILE A 376
None
0.86A 3falC-3s5wA:
undetectable
3falC-3s5wA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc2 HYPOTHETICAL PROTEIN
WITH
IMMUNOGLOBULIN-LIKE
FOLD


(Pseudomonas
aeruginosa)
PF14467
(DUF4426)
5 ILE A  59
ALA A 103
GLN A 104
PHE A 105
LEU A  88
None
0.95A 3falC-3uc2A:
undetectable
3falC-3uc2A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)


(Escherichia
virus T4;
Homo sapiens)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
5 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
None
1.04A 3falC-3v2yA:
undetectable
3falC-3v2yA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2


(Homo sapiens)
PF03006
(HlyIII)
5 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
None
0.72A 3falC-3wxwA:
undetectable
3falC-3wxwA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1


(Saccharomyces
cerevisiae)
PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N)
5 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
None
0.76A 3falC-4b8bA:
undetectable
3falC-4b8bA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djh KAPPA-TYPE OPIOID
RECEPTOR, LYSOZYME


(Escherichia
virus T4;
Homo sapiens)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
5 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
None
1.05A 3falC-4djhA:
undetectable
3falC-4djhA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia4 AQUAPORIN

(Spinacia
oleracea)
PF00230
(MIP)
5 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
None
0.81A 3falC-4ia4A:
undetectable
3falC-4ia4A:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1


(Homo sapiens)
no annotation 10 ILE D 268
ALA D 271
ALA D 272
GLN D 275
PHE D 313
ARG D 316
LEU D 326
ALA D 327
ILE D 345
CYH D 432
None
0.64A 3falC-4j5xD:
28.0
3falC-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR


(Escherichia
virus T4;
Homo sapiens)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
5 ALA A 994
PHE A1018
LEU A 998
ALA A 995
ILE A 943
None
1.01A 3falC-4ldeA:
undetectable
3falC-4ldeA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR


(Verminephrobacter
eiseniae)
PF13458
(Peripla_BP_6)
5 ILE A 191
ALA A 188
ALA A 187
LEU A 215
ALA A 214
None
1.03A 3falC-4m88A:
undetectable
3falC-4m88A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn1 TRANSCRIPTIONAL
REGULATOR


(Mycobacterium
tuberculosis)
PF00440
(TetR_N)
5 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
None
0.50A 3falC-4nn1A:
undetectable
3falC-4nn1A:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf6 C4-DICARBOXYLATE-BIN
DING PROTEIN


(Roseobacter
denitrificans)
PF03480
(DctP)
5 ILE A 242
ALA A 267
ALA A 268
LEU A  46
ALA A  45
None
0.97A 3falC-4pf6A:
undetectable
3falC-4pf6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE


(Mycolicibacterium
smegmatis)
PF04127
(DFP)
5 ALA A 277
ALA A 196
PHE A 332
ALA A 278
ILE A 405
CTP  A 500 (-4.8A)
None
None
None
None
0.99A 3falC-4qjiA:
undetectable
3falC-4qjiA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r10 PROTEIN HUMPBACK-2

(Caenorhabditis
elegans)
PF00514
(Arm)
5 ILE A 443
ALA A 447
GLN A 508
LEU A 509
ILE A 436
None
1.04A 3falC-4r10A:
undetectable
3falC-4r10A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrj PROBABLE
THREONINE--TRNA
LIGASE 2


(Aeropyrum
pernix)
PF08915
(tRNA-Thr_ED)
5 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
None
0.92A 3falC-4rrjA:
undetectable
3falC-4rrjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii)
PF02624
(YcaO)
5 ILE A 264
ALA A 261
ALA A 260
LEU A 134
ALA A 133
None
1.06A 3falC-4v1uA:
undetectable
3falC-4v1uA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbq QDE-2-INTERACTING
PROTEIN


(Neurospora
crassa)
no annotation 5 ILE A 379
ALA A 356
ALA A 381
LEU A 515
ALA A 511
None
1.04A 3falC-4wbqA:
undetectable
3falC-4wbqA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA


(Escherichia
virus T4;
Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme)
5 ALA A1128
PHE A1152
LEU A1132
ALA A1129
ILE A1077
None
1.01A 3falC-4wtvA:
undetectable
3falC-4wtvA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING


(Xanthobacter
autotrophicus)
PF02826
(2-Hacid_dh_C)
5 ILE A 296
ALA A 293
ALA A 292
LEU A  25
ALA A  24
None
0.95A 3falC-4xa8A:
undetectable
3falC-4xa8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA


(Escherichia
virus T4;
Rattus
norvegicus)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
5 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
None
1.02A 3falC-4xeeA:
undetectable
3falC-4xeeA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg0 UNCHARACTERIZED
PROTEIN


(Bordetella
bronchiseptica)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 ALA A 322
ALA A 321
LEU A 348
ALA A 347
ILE A 398
None
0.80A 3falC-4xg0A:
undetectable
3falC-4xg0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN


(Pectobacterium
atrosepticum)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 ILE A 211
ALA A 214
ALA A 215
LEU A 183
ALA A 184
None
0.69A 3falC-4xgjA:
undetectable
3falC-4xgjA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE


(Methanocaldococcus
jannaschii)
PF01946
(Thi4)
5 ILE A 132
ALA A 125
ALA A 130
LEU A  49
ILE A 136
None
1.03A 3falC-4y4mA:
undetectable
3falC-4y4mA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS


(Bartonella
clarridgeiae)
no annotation 6 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
ILE A 167
None
1.45A 3falC-4yk2A:
undetectable
3falC-4yk2A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
FAD-BINDING SUBUNIT


(Sulfurisphaera
tokodaii)
PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
5 ILE B 236
ALA B 239
ALA B 240
LEU B 226
ALA B 222
None
1.01A 3falC-4zohB:
undetectable
3falC-4zohB:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt1 HAT1-INTERACTING
FACTOR 1


(Saccharomyces
cerevisiae)
no annotation 5 ALA A  41
ALA A  42
LEU A  33
ALA A  29
ILE A 245
None
0.68A 3falC-5bt1A:
2.2
3falC-5bt1A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE


(Pseudomonas
syringae group
genomosp. 3)
PF13434
(K_oxygenase)
5 ILE A 419
ALA A 416
LEU A  25
ALA A  24
ILE A 375
None
1.02A 3falC-5cqfA:
undetectable
3falC-5cqfA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doi TELOMERASE
ASSOCIATED PROTEIN
P45


(Tetrahymena
thermophila)
no annotation 5 ILE E  52
ALA E  59
PHE E  24
LEU E  10
ILE E 105
None
1.05A 3falC-5doiE:
undetectable
3falC-5doiE:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR


(Escherichia
virus T4;
Homo sapiens)
PF00002
(7tm_2)
PF00959
(Phage_lysozyme)
5 ALA A1127
PHE A1151
LEU A1131
ALA A1128
ILE A1076
None
1.02A 3falC-5ee7A:
undetectable
3falC-5ee7A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eut PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA,ENDOLYSIN,PH
OSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA


(Escherichia
virus T4;
Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme)
5 ALA A1131
PHE A1155
LEU A1135
ALA A1132
ILE A1080
None
0.98A 3falC-5eutA:
undetectable
3falC-5eutA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT


(Homo sapiens)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol)
5 ILE C 662
PHE C 622
LEU C 623
ALA C 624
ILE C 639
None
1.02A 3falC-5exrC:
undetectable
3falC-5exrC:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE


(Vibrio cholerae)
PF01182
(Glucosamine_iso)
5 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
None
1.01A 3falC-5hj5A:
undetectable
3falC-5hj5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i14 MUTATED AND
TRUNCATED T4
LYSOZYME


(Escherichia
virus T4)
PF00959
(Phage_lysozyme)
5 ALA A  86
PHE A 110
LEU A  90
ALA A  87
ILE A  35
None
0.99A 3falC-5i14A:
undetectable
3falC-5i14A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT


(Homo sapiens)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
5 ILE A 662
PHE A 622
LEU A 623
ALA A 624
ILE A 639
None
0.93A 3falC-5iudA:
undetectable
3falC-5iudA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE


(Myxococcus
xanthus)
PF00378
(ECH_1)
5 ILE A 102
ALA A 101
ALA A 100
ALA A 190
ILE A 166
None
1.02A 3falC-5jbwA:
undetectable
3falC-5jbwA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A


(Myxococcus
xanthus)
PF01144
(CoA_trans)
5 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
None
0.94A 3falC-5mzyA:
undetectable
3falC-5mzyA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE


(Rhodobacter
capsulatus)
no annotation 5 ILE A  73
ALA A  71
ALA A 130
LEU A  67
ALA A  66
None
0.92A 3falC-5n0gA:
undetectable
3falC-5n0gA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE


(Rhodobacter
capsulatus)
no annotation 5 ILE A  73
ALA A  71
LEU A  89
ALA A  91
ILE A 160
None
1.01A 3falC-5n0gA:
undetectable
3falC-5n0gA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE


(Rhodobacter
capsulatus)
no annotation 5 ILE A 196
ALA A  44
ALA A  43
LEU A  49
ILE A 160
None
None
8F5  A 301 ( 4.1A)
None
None
0.87A 3falC-5n0gA:
undetectable
3falC-5n0gA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-)
no annotation 5 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
None
0.87A 3falC-5ohsA:
undetectable
3falC-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojl IMINE REDUCTASE

(Aspergillus
terreus)
no annotation 6 ILE A 137
ALA A 135
ALA A 125
ALA A 132
ILE A  68
CYH A  70
None
None
9X5  A 301 ( 4.8A)
None
None
None
1.28A 3falC-5ojlA:
undetectable
3falC-5ojlA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot4 INTERAPTIN

(Legionella
pneumophila)
no annotation 5 ILE A 574
ALA A 550
GLN A 549
LEU A 551
ILE A 537
None
1.05A 3falC-5ot4A:
undetectable
3falC-5ot4A:
19.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
no annotation 8 ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 428
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
1.37A 3falC-5uanA:
29.1
3falC-5uanA:
66.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
no annotation 10 ILE A 268
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
0.59A 3falC-5uanA:
29.1
3falC-5uanA:
66.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCD
MDCE


(Pseudomonas
aeruginosa)
PF01039
(Carboxyl_trans)
PF06833
(MdcE)
5 ILE A 111
ALA A 114
GLN A 113
LEU A 115
ILE B 189
None
1.02A 3falC-5vipA:
undetectable
3falC-5vipA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCD
MDCE


(Pseudomonas
aeruginosa)
PF01039
(Carboxyl_trans)
PF06833
(MdcE)
5 ILE A 111
GLN A 113
LEU A 115
ALA A 116
ILE B 189
None
1.01A 3falC-5vipA:
undetectable
3falC-5vipA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S19E, PUTATIVE


(Trichomonas
vaginalis)
PF01090
(Ribosomal_S19e)
5 ILE T  68
ALA T  65
ALA T  64
LEU T  25
ALA T  26
None
0.89A 3falC-5xyiT:
undetectable
3falC-5xyiT:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN


(Escherichia
virus T4;
Saccharomyces
cerevisiae)
no annotation 5 ALA A 129
PHE A 153
LEU A 133
ALA A 130
ILE A  78
None
1.04A 3falC-5yqrA:
undetectable
3falC-5yqrA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-)
no annotation 6 ILE A 129
ALA A 132
ALA A 133
LEU A 267
ALA A 266
ILE A 180
None
1.13A 3falC-6d95A:
undetectable
3falC-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eux POLYMERASE BASIC
PROTEIN 2


(Influenza B
virus)
no annotation 5 ILE A 312
ALA A 315
ALA A 316
LEU A 505
ILE A 273
None
0.82A 3falC-6euxA:
undetectable
3falC-6euxA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE BASIC
PROTEIN 2


(Influenza B
virus)
no annotation 5 ILE C 312
ALA C 315
ALA C 316
LEU C 505
ILE C 273
None
0.89A 3falC-6f5oC:
undetectable
3falC-6f5oC:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdg TRXA,ADENOSINE
RECEPTOR A2A


(Escherichia
coli;
Homo sapiens)
no annotation 5 ILE A 200
ALA A 203
ALA A 204
GLN A 207
ILE A 238
None
0.94A 3falC-6gdgA:
2.1
3falC-6gdgA:
13.64