SIMILAR PATTERNS OF AMINO ACIDS FOR 3F78_A_ICFA1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		5 ILE A  34
ILE A 161
LYS A 160
LEU A   1
GLU A  39
 None
 1.48A 3f78A-1ac5A:
1.8		 3f78A-1ac5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)

(Salmonella
enterica) 		PF00180
(Iso_dh) 		5 ILE A  38
TYR A   5
ILE A   7
LEU A 308
LEU A 309
 None
 0.68A 3f78A-1cnzA:
2.6		 3f78A-1cnzA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dd5 RIBOSOME RECYCLING
FACTOR

(Thermotoga
maritima) 		PF01765
(RRF) 		5 ILE A 160
ILE A 139
LYS A 138
GLU A   8
LYS A  12
 None
 0.81A 3f78A-1dd5A:
undetectable		 3f78A-1dd5A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 ILE A 640
TYR A 572
ILE A 642
LEU A 580
LEU A 578
 None
 1.41A 3f78A-1ji6A:
undetectable		 3f78A-1ji6A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v1p EXOTOXIN 1

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		5 ILE A 201
LYS A 137
GLU A 144
LEU A 145
LYS A 148
 None
 1.02A 3f78A-1v1pA:
undetectable		 3f78A-1v1pA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrp CREATINE KINASE, M
CHAIN

(Tetronarce
californica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 ILE A 299
TYR A 334
ILE A 336
LYS A 319
LEU A 312
 None
 1.43A 3f78A-1vrpA:
undetectable		 3f78A-1vrpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wer P120GAP

(Homo sapiens) 		PF00616
(RasGAP) 		5 ILE A 821
LYS A 820
GLU A 854
LEU A 855
LYS A 858
 None
 1.14A 3f78A-1werA:
undetectable		 3f78A-1werA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnf LIPOPROTEIN NLPI

(Escherichia
coli) 		PF07719
(TPR_2)
PF13181
(TPR_8) 		5 ILE A 138
TYR A 141
LEU A 276
GLU A 277
LYS A 242
 None
 1.09A 3f78A-1xnfA:
undetectable		 3f78A-1xnfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Helicobacter
pylori) 		PF02540
(NAD_synthase) 		5 ILE A 241
ILE A 219
GLU A 211
LEU A 207
LYS A 135
 None
 1.08A 3f78A-1xngA:
undetectable		 3f78A-1xngA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		5 ILE A 312
ILE A 316
LYS A 319
GLU A 290
LEU A 286
 None
 1.44A 3f78A-1xzqA:
5.2		 3f78A-1xzqA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aak UBIQUITIN
CONJUGATING ENZYME

(Arabidopsis
thaliana) 		PF00179
(UQ_con) 		5 ILE A  81
ILE A  87
LEU A 112
LEU A 113
TYR A 137
 None
 1.49A 3f78A-2aakA:
undetectable		 3f78A-2aakA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 ILE A1069
LYS A1071
LEU A1083
GLU A1079
LEU A1082
 None
 1.21A 3f78A-2bruA:
undetectable		 3f78A-2bruA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		5 ILE A 288
ILE A 297
LYS A 296
LEU A  22
GLU A  25
 None
 1.17A 3f78A-2fncA:
undetectable		 3f78A-2fncA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		5 ILE A 452
TYR A 494
ILE A 496
LEU A   6
GLU A  45
 None
 1.22A 3f78A-2fvmA:
undetectable		 3f78A-2fvmA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjm LACTOPEROXIDASE

(Bubalus bubalis) 		PF03098
(An_peroxidase) 		5 ILE A 288
ILE A 291
GLU A 256
LEU A 253
TYR A 177
 None
 1.19A 3f78A-2gjmA:
undetectable		 3f78A-2gjmA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2naz TRANSCRIPTIONAL
REGULATORY PROTEIN
RSTA

(Acinetobacter
baumannii) 		PF00486
(Trans_reg_C) 		5 ILE A 221
ILE A 211
LYS A 210
GLU A 164
LEU A 167
 None
 1.15A 3f78A-2nazA:
undetectable		 3f78A-2nazA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn6 EXOSOME COMPLEX
EXONUCLEASE RRP43
EXOSOME COMPONENT 6

(Homo sapiens) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ILE C  59
GLU F 152
LEU F 151
LYS F  61
TYR F  54
 None
 1.23A 3f78A-2nn6C:
undetectable		 3f78A-2nn6C:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp4 BILE SALT
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 ILE A  53
ILE A 198
LEU A 182
GLU A 186
LEU A 187
 None
 1.14A 3f78A-2qp4A:
undetectable		 3f78A-2qp4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp4 BILE SALT
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 ILE A 198
LYS A 197
LEU A 182
GLU A 186
LEU A 187
 None
 1.00A 3f78A-2qp4A:
undetectable		 3f78A-2qp4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rs7 ATP-DEPENDENT RNA
HELICASE A

(Mus musculus) 		PF00035
(dsrm) 		5 ILE A 219
ILE A 221
LEU A 252
LEU A 248
TYR A 200
 None
 1.48A 3f78A-2rs7A:
undetectable		 3f78A-2rs7A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  66
ILE A  63
LEU A  34
LEU A  31
TYR A 400
 None
 1.30A 3f78A-2v55A:
undetectable		 3f78A-2v55A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5e GDNF FAMILY RECEPTOR
ALPHA-1
GLIAL CELL
LINE-DERIVED
NEUROTROPHIC FACTOR

(Homo sapiens;
Rattus
norvegicus) 		PF00019
(TGF_beta)
PF02351
(GDNF) 		5 ILE A 229
TYR A 174
ILE A 293
LEU A 212
TYR B 120
 None
 1.42A 3f78A-2v5eA:
undetectable		 3f78A-2v5eA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ILE A 450
TYR A 520
ILE A 522
LYS A 497
GLU A 511
 ILE  A 450 ( 0.7A)
TYR  A 520 ( 1.3A)
ILE  A 522 ( 0.6A)
LYS  A 497 ( 0.0A)
GLU  A 511 ( 0.6A)
 1.04A 3f78A-2vbfA:
3.8		 3f78A-2vbfA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vug PAB1020

(Pyrococcus
abyssi) 		PF09414
(RNA_ligase) 		5 ILE A 191
TYR A 195
ILE A 197
LEU A 144
LEU A 142
 None
 1.36A 3f78A-2vugA:
undetectable		 3f78A-2vugA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aps DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin) 		5 ILE A 771
ILE A 775
LYS A 778
LEU A 748
GLU A 761
 None
 0.97A 3f78A-3apsA:
undetectable		 3f78A-3apsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3avs LYSINE-SPECIFIC
DEMETHYLASE 6A

(Homo sapiens) 		PF02373
(JmjC) 		5 ILE A1157
ILE A1159
GLU A1102
LEU A1103
LYS A1105
 None
EDO  A1513 (-4.5A)
None
None
None
 1.24A 3f78A-3avsA:
undetectable		 3f78A-3avsA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 ILE A 913
ILE A 952
LEU A 680
LEU A 904
TYR A 894
 None
 1.15A 3f78A-3bg9A:
undetectable		 3f78A-3bg9A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmi PUTATIVE MEMBRANE
PROTEIN COG4129

(Clostridioides
difficile) 		PF11728
(ArAE_1_C) 		5 ILE A 255
LYS A 254
LEU A 268
GLU A 271
LEU A 272
 None
 1.27A 3f78A-3kmiA:
undetectable		 3f78A-3kmiA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Ehrlichia
chaffeensis) 		PF01259
(SAICAR_synt) 		5 ILE A  89
ILE A 151
LYS A 152
LEU A 148
GLU A 134
 None
 1.41A 3f78A-3kreA:
undetectable		 3f78A-3kreA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 ILE B 142
ILE B  85
GLU B  54
LEU B  76
LYS B  58
 None
 1.36A 3f78A-3m2rB:
undetectable		 3f78A-3m2rB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muu STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		5 ILE A 642
TYR A 361
ILE A 640
LEU A 389
LEU A 387
 None
 1.06A 3f78A-3muuA:
undetectable		 3f78A-3muuA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		5 ILE A 218
ILE A 214
LEU A 173
GLU A 169
LYS A 251
 None
 1.39A 3f78A-3mzvA:
undetectable		 3f78A-3mzvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2i EXOTOXIN 5

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		5 ILE A 224
LYS A 160
GLU A 167
LEU A 168
LYS A 171
 None
 1.19A 3f78A-3r2iA:
undetectable		 3f78A-3r2iA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vml 3-ISOPROPYLMALATE
DEHYDROGENASE

(Shewanella
benthica;
Shewanella
oneidensis) 		PF00180
(Iso_dh) 		5 ILE A  36
TYR A   3
ILE A   5
LEU A 306
LEU A 307
 None
 0.86A 3f78A-3vmlA:
2.3		 3f78A-3vmlA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn5 RIBONUCLEASE HIII

(Aquifex
aeolicus) 		PF01351
(RNase_HII) 		5 ILE A   6
ILE A  14
LYS A  13
LEU A  67
LEU A  68
 None
 1.46A 3f78A-3vn5A:
undetectable		 3f78A-3vn5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 ILE A  40
TYR A  25
ILE A  39
LEU A  42
TYR A 353
 None
 1.29A 3f78A-3w3aA:
3.5		 3f78A-3w3aA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zla NUCLEOPROTEIN

(Bunyamwera
orthobunyavirus) 		PF00952
(Bunya_nucleocap) 		5 ILE A 122
TYR A  36
LEU A  99
LEU A 103
LYS A 106
 None
 1.18A 3f78A-3zlaA:
undetectable		 3f78A-3zlaA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpx LIPASE

(Ustilago maydis) 		PF03583
(LIP) 		5 ILE A 125
LEU A 371
GLU A 370
LEU A 374
TYR A  90
 None
 1.33A 3f78A-3zpxA:
4.0		 3f78A-3zpxA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b18 IMPORTIN SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ILE A 472
ILE A 481
LEU A 499
GLU A 448
LEU A 451
 None
 1.30A 3f78A-4b18A:
undetectable		 3f78A-4b18A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ita SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Synechococcus
sp. PCC 7002) 		PF00171
(Aldedh) 		5 ILE A 313
ILE A 309
GLU A 359
LEU A 360
LYS A 266
 EDO  A 507 ( 4.2A)
EDO  A 507 ( 4.7A)
NDP  A 501 ( 2.9A)
None
NDP  A 501 ( 4.8A)
 1.44A 3f78A-4itaA:
2.6		 3f78A-4itaA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxn OCTAPRENYL-DIPHOSPHA
TE SYNTHASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 ILE A 218
ILE A 214
LEU A 173
GLU A 169
LYS A 251
 None
 1.48A 3f78A-4jxnA:
undetectable		 3f78A-4jxnA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r72 ABC-TYPE FE3+
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Actinobacillus
pleuropneumoniae) 		PF13343
(SBP_bac_6) 		5 ILE A 104
TYR A 228
ILE A 106
LEU A 288
LEU A 285
 None
None
None
GOL  A 404 (-3.9A)
None
 1.47A 3f78A-4r72A:
undetectable		 3f78A-4r72A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r72 ABC-TYPE FE3+
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Actinobacillus
pleuropneumoniae) 		PF13343
(SBP_bac_6) 		5 ILE A 104
TYR A 228
ILE A 106
LEU A 288
LYS A  87
 None
None
None
GOL  A 404 (-3.9A)
None
 1.02A 3f78A-4r72A:
undetectable		 3f78A-4r72A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzz PEPTIDASE M24

(Ruegeria
lacuscaerulensis) 		PF00557
(Peptidase_M24) 		5 ILE A 299
ILE A 304
LEU A 375
GLU A 378
LEU A  81
 None
 1.45A 3f78A-4rzzA:
undetectable		 3f78A-4rzzA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ILE A 470
ILE A 479
LEU A 497
GLU A 446
LEU A 449
 None
 1.31A 3f78A-4uadA:
undetectable		 3f78A-4uadA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy4 SPINDLIN-4

(Homo sapiens) 		PF02513
(Spin-Ssty) 		5 ILE A  75
ILE A 210
LYS A 223
LEU A  73
TYR A  78
 GOL  A1237 ( 4.0A)
GOL  A1237 (-4.0A)
None
None
None
 1.28A 3f78A-4uy4A:
undetectable		 3f78A-4uy4A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG

(Thermotoga
maritima) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
PF10418
(DHODB_Fe-S_bind) 		5 ILE A  41
ILE A  50
GLU A  77
LEU A  78
LYS A  81
 None
FAD  A 502 ( 4.4A)
None
None
None
 1.33A 3f78A-4yryA:
3.0		 3f78A-4yryA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a30 MITOCHONDRIAL
PROTEIN

(Gallus gallus) 		PF03828
(PAP_assoc) 		5 ILE A 107
ILE A  92
LEU A  83
GLU A  79
LEU A  82
 None
 1.20A 3f78A-5a30A:
undetectable		 3f78A-5a30A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8j VWA2

(Sulfolobus
acidocaldarius) 		PF00092
(VWA) 		5 ILE A 163
TYR A 186
ILE A 188
GLU A 200
LEU A 198
 None
 1.09A 3f78A-5a8jA:
17.3		 3f78A-5a8jA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ay6 FLAGELLAR HOOK
PROTEIN FLGE

(Caulobacter
vibrioides) 		PF07559
(FlaE) 		5 ILE A 261
ILE A 235
LEU A 290
LEU A 287
TYR A 249
 None
 1.32A 3f78A-5ay6A:
undetectable		 3f78A-5ay6A:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 ILE A 235
TYR A 257
ILE A 259
LEU A 298
GLU A 301
 None
 0.87A 3f78A-5e6sA:
34.9		 3f78A-5e6sA:
76.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 ILE A 235
TYR A 257
ILE A 259
LYS A 287
LEU A 298
 None
 0.38A 3f78A-5e6sA:
34.9		 3f78A-5e6sA:
76.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		5 ILE A 280
TYR A 313
ILE A 315
LEU A 183
GLU A 186
 None
 1.26A 3f78A-5e9jA:
undetectable		 3f78A-5e9jA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elg GLUTATHIONE
S-TRANSFERASE DHAR1,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 ILE A  39
LEU A  30
GLU A  31
LEU A  27
LYS A 195
 None
 1.24A 3f78A-5elgA:
undetectable		 3f78A-5elgA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A

(Homo sapiens) 		PF03643
(Vps26) 		5 ILE B 248
ILE B 195
LEU B 276
LEU B 274
TYR B 185
 None
 1.26A 3f78A-5f0lB:
undetectable		 3f78A-5f0lB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxv HISTONE DEMETHYLASE
UTY

(Homo sapiens) 		PF02373
(JmjC) 		5 ILE A1104
ILE A1106
GLU A1049
LEU A1050
LYS A1052
 None
 1.25A 3f78A-5fxvA:
undetectable		 3f78A-5fxvA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2f TYPE-IV LIKE PILIN
TTHA1222

(Thermus
thermophilus) 		no annotation 5 ILE A  98
TYR A 112
ILE A  88
LEU A  54
GLU A  55
 None
 1.28A 3f78A-5g2fA:
undetectable		 3f78A-5g2fA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwt 4-HYDROXYISOLECUINE
DEHYDROGENASE

(Bacillus
thuringiensis) 		no annotation 5 ILE A   6
ILE A  32
LYS A  52
LEU A  71
GLU A  74
 None
 1.14A 3f78A-5gwtA:
3.6		 3f78A-5gwtA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kl0 PHOSPHOGLUCOMUTASE

(Xanthomonas
citri) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ILE A 288
LYS A 291
LEU A 364
GLU A 367
LEU A 368
 None
 1.48A 3f78A-5kl0A:
undetectable		 3f78A-5kl0A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 ILE A  63
ILE A  74
LYS A 137
LEU A 176
GLU A   7
 None
 1.37A 3f78A-5kp7A:
undetectable		 3f78A-5kp7A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 5 ILE A 176
ILE A 177
GLU A 217
LYS A 215
TYR A 517
 None
 1.39A 3f78A-5xv7A:
undetectable		 3f78A-5xv7A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 5 TYR A 565
LEU A  43
GLU A  46
LEU A  47
LYS A  50
 None
 1.13A 3f78A-5yj6A:
undetectable		 3f78A-5yj6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckb -

(-) 		no annotation 6 ILE A 217
TYR A 239
ILE A 241
LYS A 269
LEU A 280
LYS A 287
 None
 1.03A 3f78A-6ckbA:
33.6		 3f78A-6ckbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cy1 SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Elizabethkingia
anophelis) 		no annotation 5 ILE A 279
ILE A  66
LYS A  65
LEU A  96
LEU A  97
 None
 1.16A 3f78A-6cy1A:
3.0		 3f78A-6cy1A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g8r NUCLEAR BODY PROTEIN
SP140

(Homo sapiens) 		no annotation 5 ILE B 826
ILE B 804
LYS B 803
GLU B 797
TYR B 785
 None
 1.37A 3f78A-6g8rB:
undetectable		 3f78A-6g8rB:
17.39