SIMILAR PATTERNS OF AMINO ACIDS FOR 3F33_A_PFLA2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A  87
LEU A  48
ARG A  41
LEU A  96
 None
 1.02A 3f33A-1bbuA:
undetectable		 3f33A-1bbuA:
16.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bg7 FERRITIN

(Rana
catesbeiana) 		PF00210
(Ferritin) 		5 LEU A  24
SER A  27
TYR A  28
LEU A  31
ARG A  59
 None
 0.32A 3f33A-1bg7A:
23.8		 3f33A-1bg7A:
58.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c72 PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Gallus gallus) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A 122
TYR A 126
LEU A 129
LEU A 113
 None
 0.98A 3f33A-1c72A:
undetectable		 3f33A-1c72A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		4 SER M 491
TYR M 495
LEU M 433
LEU M  89
 None
 0.78A 3f33A-1dwaM:
undetectable		 3f33A-1dwaM:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5m GAF

(Saccharomyces
cerevisiae) 		PF13185
(GAF_2) 		5 LEU A  28
SER A  31
TYR A  32
LEU A  35
LEU A 169
 None
 1.40A 3f33A-1f5mA:
undetectable		 3f33A-1f5mA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvf SEC1

(Doryteuthis
pealeii) 		PF00995
(Sec1) 		4 LEU A 346
SER A 343
TYR A 342
LEU A 339
 None
 1.05A 3f33A-1fvfA:
2.4		 3f33A-1fvfA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hna GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A 141
SER A 138
TYR A 137
LEU A 134
 None
 0.93A 3f33A-1hnaA:
undetectable		 3f33A-1hnaA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		4 LEU A 610
SER A 613
LEU A 617
LEU A 633
 None
 1.02A 3f33A-1j1wA:
undetectable		 3f33A-1j1wA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 LEU A 416
TYR A 420
LEU A 423
LEU A 440
 None
 1.01A 3f33A-1jqoA:
3.1		 3f33A-1jqoA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		4 LEU A 298
SER A 299
LEU A 301
LEU A 158
 None
 1.05A 3f33A-1jy1A:
undetectable		 3f33A-1jy1A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kc8 RIBOSOMAL PROTEIN
L18

(Haloarcula
marismortui) 		PF17144
(Ribosomal_L5e) 		4 LEU O  83
LEU O  90
ARG O 176
LEU O  66
 None
 1.05A 3f33A-1kc8O:
undetectable		 3f33A-1kc8O:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		4 LEU A 240
SER A 239
ARG A 207
LEU A 244
 None
 1.04A 3f33A-1ktnA:
undetectable		 3f33A-1ktnA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lb3 FERRITIN LIGHT CHAIN
1

(Mus musculus) 		PF00210
(Ferritin) 		5 LEU A  28
SER A  31
TYR A  32
LEU A  35
ARG A  63
 None
 0.19A 3f33A-1lb3A:
29.1		 3f33A-1lb3A:
81.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 LEU A 559
SER A 562
TYR A 563
LEU A 555
 None
 0.85A 3f33A-1ldjA:
2.3		 3f33A-1ldjA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lki LEUKEMIA INHIBITORY
FACTOR

(Mus musculus) 		PF01291
(LIF_OSM) 		4 LEU A  40
SER A  43
TYR A  44
LEU A 166
 None
 0.86A 3f33A-1lkiA:
5.0		 3f33A-1lkiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo2 ERYTHRONOLIDE
SYNTHASE, MODULES 5
AND 6

(Saccharopolyspora
erythraea) 		PF00975
(Thioesterase) 		4 SER A  33
TYR A  34
LEU A  37
LEU A 190
 None
 0.98A 3f33A-1mo2A:
undetectable		 3f33A-1mo2A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orq POTASSIUM CHANNEL

(Aeropyrum
pernix) 		PF00520
(Ion_trans) 		4 LEU C  29
SER C  32
TYR C  33
LEU C  36
 None
 0.80A 3f33A-1orqC:
3.1		 3f33A-1orqC:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvb BETA-GLYCOSIDASE

(Thermosphaera
aggregans) 		PF00232
(Glyco_hydro_1) 		4 LEU A 374
TYR A 375
ARG A 377
LEU A 382
 None
 0.87A 3f33A-1qvbA:
undetectable		 3f33A-1qvbA:
17.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r03 MITOCHONDRIAL
FERRITIN

(Homo sapiens) 		PF00210
(Ferritin) 		4 LEU A  28
SER A  31
TYR A  32
LEU A  35
 None
 0.16A 3f33A-1r03A:
27.5		 3f33A-1r03A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		4 LEU A 213
SER A 216
LEU A 220
LEU A 181
 None
 0.71A 3f33A-1su7A:
undetectable		 3f33A-1su7A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 LEU A 431
TYR A 435
LEU A 438
LEU A 547
 None
 0.88A 3f33A-1t1uA:
undetectable		 3f33A-1t1uA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t71 PHOSPHATASE

(Mycoplasma
pneumoniae) 		PF13277
(YmdB) 		4 SER A  52
TYR A  56
LEU A  53
LEU A  59
 None
 1.03A 3f33A-1t71A:
undetectable		 3f33A-1t71A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w4t ARYLAMINE
N-ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00797
(Acetyltransf_2) 		4 LEU A  91
TYR A  89
LEU A  87
LEU A 118
 None
 0.86A 3f33A-1w4tA:
undetectable		 3f33A-1w4tA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		4 SER A 227
LEU A 226
ARG A 116
LEU A 113
 None
None
MG  A 401 (-3.4A)
None
 0.97A 3f33A-1wpwA:
undetectable		 3f33A-1wpwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 SER B  58
TYR B  54
LEU B  57
ARG B  59
LEU A  85
 None
 1.40A 3f33A-1wytB:
undetectable		 3f33A-1wytB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9z DNA MISMATCH REPAIR
PROTEIN MUTL

(Escherichia
coli) 		PF08676
(MutL_C) 		4 SER A 456
LEU A 458
ARG A 451
LEU A 439
 None
 0.93A 3f33A-1x9zA:
undetectable		 3f33A-1x9zA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438

(Mycoplasma
genitalium) 		PF01420
(Methylase_S) 		4 LEU A 355
TYR A 351
LEU A 348
LEU A 163
 None
 1.02A 3f33A-1ydxA:
1.5		 3f33A-1ydxA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		4 LEU A 119
SER A 122
ARG A 152
LEU A  73
 None
 0.88A 3f33A-2b25A:
undetectable		 3f33A-2b25A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5f HYPOTHETICAL PROTEIN
PH0510

(Pyrococcus
horikoshii) 		PF01380
(SIS) 		5 LEU A  37
SER A  46
TYR A  36
LEU A  49
LEU A  35
 None
 1.45A 3f33A-2e5fA:
undetectable		 3f33A-2e5fA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 115
LEU A 107
ARG A 116
LEU A  36
 None
 0.97A 3f33A-2eq9A:
undetectable		 3f33A-2eq9A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm8 CELL INVASION
PROTEIN SIPA
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK

(Salmonella
enterica) 		PF03519
(Invas_SpaK)
PF09052
(SipA) 		4 LEU A 119
TYR A 123
LEU A 126
LEU C  27
 None
 0.95A 3f33A-2fm8A:
undetectable		 3f33A-2fm8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus cereus) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		4 LEU A  18
SER A  21
TYR A  22
LEU A  25
 None
 0.61A 3f33A-2fq4A:
undetectable		 3f33A-2fq4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		4 LEU A 288
TYR A 292
LEU A 259
LEU A 296
 None
 1.05A 3f33A-2gouA:
undetectable		 3f33A-2gouA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3j HYPOTHETICAL PROTEIN
PA4359

(Pseudomonas
aeruginosa) 		PF04023
(FeoA) 		4 LEU A  68
SER A  16
TYR A  15
LEU A  27
 None
 1.02A 3f33A-2h3jA:
undetectable		 3f33A-2h3jA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibp CITRATE SYNTHASE

(Pyrobaculum
aerophilum) 		PF00285
(Citrate_synt) 		4 SER A  66
TYR A  67
LEU A  70
LEU A  80
 None
 0.84A 3f33A-2ibpA:
2.8		 3f33A-2ibpA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 LEU A 254
SER A 323
LEU A 322
LEU A 250
 None
 1.03A 3f33A-2iu3A:
undetectable		 3f33A-2iu3A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcs DEOXYNUCLEOSIDE
KINASE

(Drosophila
melanogaster) 		PF01712
(dNK) 		4 SER A  82
TYR A  83
LEU A  86
LEU A  65
 None
 0.72A 3f33A-2jcsA:
undetectable		 3f33A-2jcsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyh VOLTAGE-GATED
POTASSIUM CHANNEL

(Aeropyrum
pernix) 		no annotation 4 LEU A  29
SER A  32
TYR A  33
LEU A  36
 None
 0.57A 3f33A-2kyhA:
3.6		 3f33A-2kyhA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ld3 MYOSIN VI

(Mus musculus) 		no annotation 4 LEU A  55
SER A  58
LEU A  62
LEU A  31
 None
 1.01A 3f33A-2ld3A:
3.5		 3f33A-2ld3A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lm0 AF4/FMR2 FAMILY
MEMBER 1/PROTEIN
AF-9 CHIMERA

(Homo sapiens) 		PF05110
(AF-4) 		4 LEU A 770
SER A 771
ARG A 772
LEU A 767
 None
 1.01A 3f33A-2lm0A:
undetectable		 3f33A-2lm0A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2no5 (S)-2-HALOACID
DEHALOGENASE IVA

(Burkholderia
cepacia) 		PF13419
(HAD_2) 		4 LEU A  73
TYR A  76
ARG A  74
LEU A  37
 None
None
SO4  A1002 ( 3.1A)
None
 1.03A 3f33A-2no5A:
undetectable		 3f33A-2no5A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nra PI PROTEIN

(Escherichia
coli) 		PF01051
(Rep_3) 		4 LEU C 174
SER C 171
TYR C 170
LEU C 202
 None
 0.84A 3f33A-2nraC:
undetectable		 3f33A-2nraC:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxo HYPOTHETICAL PROTEIN
SCO4506

(Streptomyces
coelicolor) 		PF02621
(VitK2_biosynth) 		5 LEU A  20
SER A 216
LEU A 215
ARG A 213
LEU A  24
 None
 1.48A 3f33A-2nxoA:
undetectable		 3f33A-2nxoA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oce HYPOTHETICAL PROTEIN
PA5201

(Pseudomonas
aeruginosa) 		PF00575
(S1)
PF09371
(Tex_N)
PF12836
(HHH_3)
PF16921
(Tex_YqgF) 		4 LEU A  78
LEU A 107
ARG A  74
LEU A  87
 None
 0.83A 3f33A-2oceA:
undetectable		 3f33A-2oceA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2w CITRATE SYNTHASE

(Thermotoga
maritima) 		PF00285
(Citrate_synt) 		4 LEU A 165
SER A 168
LEU A 172
LEU A 306
 None
 0.92A 3f33A-2p2wA:
undetectable		 3f33A-2p2wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 LEU A 117
LEU A  79
ARG A 120
LEU A  83
 None
 1.01A 3f33A-2pajA:
undetectable		 3f33A-2pajA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pft EXOCYTOSIS PROTEIN

(Mus musculus) 		PF03081
(Exo70) 		4 LEU A 292
SER A 295
LEU A 299
LEU A 227
 None
 0.73A 3f33A-2pftA:
2.5		 3f33A-2pftA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		4 LEU A 191
SER A 193
LEU A 197
LEU A 139
 None
 1.05A 3f33A-2q3yA:
undetectable		 3f33A-2q3yA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F

(Enterococcus
faecium) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		4 LEU A 486
SER A 489
TYR A 490
LEU A 493
 None
 0.69A 3f33A-2qr4A:
2.2		 3f33A-2qr4A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1)
PF13949
(ALIX_LYPXL_bnd) 		4 TYR A 608
LEU A 604
ARG A 380
LEU A 573
 None
 0.85A 3f33A-2r05A:
4.2		 3f33A-2r05A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		4 LEU A 484
TYR A 488
LEU A 491
LEU A 467
 None
 0.80A 3f33A-2vmfA:
undetectable		 3f33A-2vmfA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsm HEMAGGLUTININ-NEURAM
INIDASE

(Nipah
henipavirus) 		PF00423
(HN) 		4 LEU A 265
TYR A 205
LEU A 207
LEU A 592
 None
 1.01A 3f33A-2vsmA:
undetectable		 3f33A-2vsmA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA

(Escherichia
coli) 		PF02563
(Poly_export)
PF10531
(SLBB) 		4 LEU A  79
SER A  82
TYR A  83
LEU A 240
 None
 1.04A 3f33A-2w8iA:
undetectable		 3f33A-2w8iA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0s PYRUVATE PHOSPHATE
DIKINASE

(Trypanosoma
brucei) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 SER A 526
LEU A 423
ARG A 421
LEU A 473
 None
 0.92A 3f33A-2x0sA:
undetectable		 3f33A-2x0sA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		4 LEU A 365
TYR A 366
ARG A 368
LEU A 373
 None
 0.76A 3f33A-2xhyA:
undetectable		 3f33A-2xhyA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		4 LEU A 371
SER A 374
LEU A 378
LEU A 336
 None
 0.79A 3f33A-2yxlA:
undetectable		 3f33A-2yxlA:
18.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2za8 FERRITIN LIGHT CHAIN

(Equus caballus) 		PF00210
(Ferritin) 		6 LEU A  25
SER A  28
TYR A  29
LEU A  32
ARG A  60
LEU A  82
 None
 0.52A 3f33A-2za8A:
28.4		 3f33A-2za8A:
99.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		4 LEU A  16
SER A  19
ARG A  62
LEU A  69
 None
 1.04A 3f33A-2zq5A:
undetectable		 3f33A-2zq5A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		4 LEU A  16
SER A  19
LEU A  23
LEU A  69
 None
 0.97A 3f33A-2zq5A:
undetectable		 3f33A-2zq5A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqs BACTERIAL REGULATORY
PROTEINS, TETR
FAMILY

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		4 LEU A  35
SER A  38
LEU A  42
LEU A  77
 None
 0.97A 3f33A-3aqsA:
undetectable		 3f33A-3aqsA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 LEU A 299
SER A 302
LEU A 306
LEU A 335
 None
 0.93A 3f33A-3c6mA:
undetectable		 3f33A-3c6mA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25

(Homo sapiens) 		PF05871
(ESCRT-II) 		4 LEU C  36
SER C  39
LEU C  43
LEU C  59
 None
 1.01A 3f33A-3cuqC:
undetectable		 3f33A-3cuqC:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dad FH1/FH2
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 4 LEU A 280
TYR A 276
LEU A 273
LEU A 227
 None
 0.93A 3f33A-3dadA:
undetectable		 3f33A-3dadA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr PROTEIN VP3

(Rhinovirus A) 		PF00073
(Rhv) 		4 LEU C 209
SER C  69
TYR C  68
LEU C  52
 None
 0.85A 3f33A-3dprC:
undetectable		 3f33A-3dprC:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2s PROLINE
DEHYDROGENASE

(Escherichia
coli) 		PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 LEU A 349
TYR A 350
ARG A 352
LEU A 383
 None
 1.02A 3f33A-3e2sA:
undetectable		 3f33A-3e2sA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		4 LEU A  44
TYR A  45
ARG A  47
LEU A  10
 None
 0.91A 3f33A-3e53A:
undetectable		 3f33A-3e53A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exn PROBABLE
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00583
(Acetyltransf_1) 		4 LEU A  92
TYR A  73
LEU A  63
ARG A  94
 ACO  A1001 (-4.3A)
None
None
None
 0.93A 3f33A-3exnA:
undetectable		 3f33A-3exnA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exn PROBABLE
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00583
(Acetyltransf_1) 		4 LEU A  92
TYR A  73
LEU A  63
LEU A  90
 ACO  A1001 (-4.3A)
None
None
ACO  A1001 (-4.7A)
 1.01A 3f33A-3exnA:
undetectable		 3f33A-3exnA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdl ROYAL PALM TREE
PEROXIDASE

(Roystonea regia) 		PF00141
(peroxidase) 		4 SER A 199
TYR A 200
LEU A 203
LEU A 242
 None
 1.03A 3f33A-3hdlA:
undetectable		 3f33A-3hdlA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		4 LEU A 370
TYR A 401
LEU A 397
ARG A 318
 None
 1.02A 3f33A-3hxwA:
undetectable		 3f33A-3hxwA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isa PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Bordetella
parapertussis) 		PF00378
(ECH_1) 		4 LEU A  23
SER A  24
LEU A   8
LEU A  36
 None
 0.94A 3f33A-3isaA:
undetectable		 3f33A-3isaA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Streptomyces
mobaraensis) 		PF09017
(Transglut_prok) 		4 SER A 218
TYR A 217
ARG A 213
LEU A 193
 None
 1.04A 3f33A-3iu0A:
undetectable		 3f33A-3iu0A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 LEU A1124
SER A1123
TYR A1129
LEU A1132
 None
 0.98A 3f33A-3l4kA:
3.0		 3f33A-3l4kA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1

(Saccharomyces
cerevisiae) 		PF02383
(Syja_N) 		4 LEU X 433
SER X 436
TYR X 437
LEU X 440
 None
 1.04A 3f33A-3lwtX:
undetectable		 3f33A-3lwtX:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Novosphingobium
aromaticivorans) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 SER A 197
TYR A 200
LEU A 196
LEU A 165
 None
 0.99A 3f33A-3lxdA:
undetectable		 3f33A-3lxdA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacteroides
thetaiotaomicron) 		PF08543
(Phos_pyr_kin) 		4 LEU A 173
TYR A 169
LEU A 166
LEU A 153
 None
 0.94A 3f33A-3mbhA:
undetectable		 3f33A-3mbhA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkq COATOMER
BETA'-SUBUNIT

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		4 LEU A 687
LEU A 674
ARG A 672
LEU A 663
 None
 1.05A 3f33A-3mkqA:
undetectable		 3f33A-3mkqA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzk PROTEIN TRANSPORT
PROTEIN SEC16

(Saccharomyces
cerevisiae) 		PF12931
(Sec16_C)
PF12932
(Sec16) 		4 LEU B1361
SER B1364
LEU B1368
LEU B1382
 None
 0.78A 3f33A-3mzkB:
undetectable		 3f33A-3mzkB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8j 2-METHYLCITRATE
SYNTHASE

(Salmonella
enterica) 		PF00285
(Citrate_synt) 		4 LEU A  86
SER A 142
LEU A 143
LEU A  83
 None
 1.05A 3f33A-3o8jA:
undetectable		 3f33A-3o8jA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohe HISTIDINE TRIAD
(HIT) PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF01230
(HIT) 		4 LEU A  64
SER A  61
LEU A  57
LEU A 135
 None
 1.03A 3f33A-3oheA:
undetectable		 3f33A-3oheA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oit OS07G0271500 PROTEIN

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 LEU A 101
SER A 100
ARG A 271
LEU A 105
 None
 1.04A 3f33A-3oitA:
undetectable		 3f33A-3oitA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq3 INTERFERON ALPHA-5

(Mus musculus) 		PF00143
(Interferon) 		4 LEU A 152
SER A 155
LEU A 159
LEU A  15
 None
 1.05A 3f33A-3oq3A:
4.0		 3f33A-3oq3A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe0 PLECTIN

(Homo sapiens) 		PF00435
(Spectrin) 		4 SER A 684
TYR A 685
LEU A 688
LEU A 745
 None
 0.65A 3f33A-3pe0A:
4.3		 3f33A-3pe0A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00342
(PGI) 		4 LEU A   8
SER A  10
TYR A  11
LEU A  14
 None
 1.05A 3f33A-3qkiA:
undetectable		 3f33A-3qkiA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		4 LEU A 394
SER A 397
TYR A 398
LEU A 359
 None
 0.83A 3f33A-3qmlA:
undetectable		 3f33A-3qmlA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6n DESMOPLAKIN

(Homo sapiens) 		no annotation 4 LEU A 251
TYR A 255
LEU A 258
LEU A 235
 None
 0.90A 3f33A-3r6nA:
4.8		 3f33A-3r6nA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 4 LEU J 143
SER J 145
LEU J 149
LEU N 134
 None
 0.77A 3f33A-3rkoJ:
undetectable		 3f33A-3rkoJ:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sog AMPHIPHYSIN

(Homo sapiens) 		PF03114
(BAR) 		4 LEU A 113
SER A 117
LEU A 121
LEU A  64
 None
 0.94A 3f33A-3sogA:
4.4		 3f33A-3sogA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 LEU A 691
TYR A 695
LEU A 698
LEU A 678
 None
 0.66A 3f33A-3u44A:
5.1		 3f33A-3u44A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 LEU A 103
TYR A 104
ARG A 106
LEU A 144
 None
 0.98A 3f33A-3uc3A:
2.8		 3f33A-3uc3A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis) 		PF00128
(Alpha-amylase) 		4 SER A 422
TYR A 425
LEU A 421
LEU A 457
 None
 1.02A 3f33A-3ucqA:
undetectable		 3f33A-3ucqA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufg GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT

(Campylobacter
jejuni) 		PF02091
(tRNA-synt_2e) 		4 LEU A  93
SER A  95
LEU A  99
LEU A 103
 None
 1.04A 3f33A-3ufgA:
undetectable		 3f33A-3ufgA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 265
SER A 268
LEU A 272
LEU A 282
 None
 0.75A 3f33A-3viuA:
undetectable		 3f33A-3viuA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuo NTNHA

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 LEU A 226
SER A 229
LEU A 233
LEU A  98
 None
 1.04A 3f33A-3vuoA:
3.0		 3f33A-3vuoA:
9.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wnw FERRITIN HEAVY CHAIN

(Mus musculus) 		PF00210
(Ferritin) 		4 LEU A  28
SER A  31
TYR A  32
LEU A  35
 None
 0.16A 3f33A-3wnwA:
27.7		 3f33A-3wnwA:
48.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		4 LEU A 410
TYR A 414
LEU A 417
LEU A 434
 None
 1.04A 3f33A-3zgbA:
3.7		 3f33A-3zgbA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		4 SER A 418
TYR A 422
LEU A 362
LEU A  69
 None
 0.65A 3f33A-3zjkA:
undetectable		 3f33A-3zjkA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7y MALE-SPECIFIC LETHAL
2 HOMOLOG

(Homo sapiens) 		PF16685
(zf-RING_10) 		4 LEU C  99
TYR C 103
LEU C 106
LEU C  42
 None
 0.71A 3f33A-4b7yC:
undetectable		 3f33A-4b7yC:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj1 PROTEIN RIF2

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 305
SER A 308
TYR A 309
LEU A 312
 None
 0.90A 3f33A-4bj1A:
undetectable		 3f33A-4bj1A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj6 RAP1-INTERACTING
FACTOR 2

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 305
SER A 308
TYR A 309
LEU A 312
 None
 0.75A 3f33A-4bj6A:
undetectable		 3f33A-4bj6A:
18.62