SIMILAR PATTERNS OF AMINO ACIDS FOR 3ETE_B_H3PB552

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 TYR A 137
TYR A 159
ILE A 170
 None
 0.73A 3eteA-1b3bA:
50.1
3eteB-1b3bA:
50.2		 3eteA-1b3bA:
41.78
3eteB-1b3bA:
41.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 TYR A 127
TYR A 108
ILE A 124
 ADP  A 998 (-4.4A)
None
None
 0.80A 3eteA-1br2A:
0.0
3eteB-1br2A:
0.0		 3eteA-1br2A:
20.75
3eteB-1br2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		3 TYR A 287
TYR A 416
ILE A 359
 None
 0.66A 3eteA-1dj2A:
0.0
3eteB-1dj2A:
0.9		 3eteA-1dj2A:
21.70
3eteB-1dj2A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		3 TYR A 286
TYR A 415
ILE A 358
 None
 0.72A 3eteA-1dj3A:
undetectable
3eteB-1dj3A:
0.4		 3eteA-1dj3A:
22.12
3eteB-1dj3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eys PHOTOSYNTHETIC
REACTION CENTER

(Thermochromatium
tepidum) 		PF02276
(CytoC_RC) 		3 TYR C  22
TYR C 297
ILE C  31
 None
 0.57A 3eteA-1eysC:
undetectable
3eteB-1eysC:
undetectable		 3eteA-1eysC:
20.63
3eteB-1eysC:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gtm GLUTAMATE
DEHYDROGENASE

(Pyrococcus
furiosus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 TYR A 137
TYR A 159
ILE A 172
 None
 0.75A 3eteA-1gtmA:
49.2
3eteB-1gtmA:
49.3		 3eteA-1gtmA:
38.43
3eteB-1gtmA:
38.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		3 TYR S 127
TYR S 108
ILE S 124
 None
 0.74A 3eteA-1i84S:
0.0
3eteB-1i84S:
undetectable		 3eteA-1i84S:
18.60
3eteB-1i84S:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		3 TYR A 497
TYR A 574
ILE A 440
 None
 0.71A 3eteA-1jy1A:
0.3
3eteB-1jy1A:
undetectable		 3eteA-1jy1A:
21.83
3eteB-1jy1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		3 TYR A 159
TYR A 111
ILE A 110
 None
 0.82A 3eteA-1kxhA:
undetectable
3eteB-1kxhA:
undetectable		 3eteA-1kxhA:
21.00
3eteB-1kxhA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mf1 ADENYLOSUCCINATE
SYNTHETASE

(Mus musculus) 		PF00709
(Adenylsucc_synt) 		3 TYR A 301
TYR A 429
ILE A 373
 None
 0.77A 3eteA-1mf1A:
undetectable
3eteB-1mf1A:
undetectable		 3eteA-1mf1A:
21.45
3eteB-1mf1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhc MHC CLASS I ANTIGEN
H2-M3

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 TYR A   7
TYR A  22
ILE A  70
 None
 0.79A 3eteA-1mhcA:
undetectable
3eteB-1mhcA:
undetectable		 3eteA-1mhcA:
21.29
3eteB-1mhcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt6 SET9

(Homo sapiens) 		PF00856
(SET)
PF02493
(MORN) 		3 TYR A 245
TYR A 287
ILE A 201
 None
 0.83A 3eteA-1mt6A:
undetectable
3eteB-1mt6A:
undetectable		 3eteA-1mt6A:
21.23
3eteB-1mt6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		3 TYR A 125
TYR A 174
ILE A 252
 None
 0.59A 3eteA-1nj8A:
undetectable
3eteB-1nj8A:
undetectable		 3eteA-1nj8A:
22.92
3eteB-1nj8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9b ADENYLOSUCCINATE
SYNTHETASE

(Plasmodium
falciparum) 		PF00709
(Adenylsucc_synt) 		3 TYR A 277
TYR A 409
ILE A 349
 None
 0.76A 3eteA-1p9bA:
0.8
3eteB-1p9bA:
undetectable		 3eteA-1p9bA:
21.90
3eteB-1p9bA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q67 DECAPPING PROTEIN
INVOLVED IN MRNA
DEGRADATION-DCP1P

(Saccharomyces
cerevisiae) 		PF06058
(DCP1) 		3 TYR A  30
TYR A  68
ILE A  34
 None
 0.75A 3eteA-1q67A:
undetectable
3eteB-1q67A:
undetectable		 3eteA-1q67A:
19.35
3eteB-1q67A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 TYR A 401
TYR A 269
ILE A 267
 AZ1  A 502 ( 4.1A)
None
None
 0.75A 3eteA-1tufA:
undetectable
3eteB-1tufA:
undetectable		 3eteA-1tufA:
22.86
3eteB-1tufA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxa AFADIN

(Mus musculus) 		PF00788
(RA) 		3 TYR A  25
TYR A  47
ILE A  23
 None
 0.71A 3eteA-1wxaA:
undetectable
3eteB-1wxaA:
undetectable		 3eteA-1wxaA:
15.30
3eteB-1wxaA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbs HYPOTHETICAL PROTEIN
PG1100

(Porphyromonas
gingivalis) 		PF01869
(BcrAD_BadFG) 		3 TYR A 187
TYR A 139
ILE A 140
 None
 0.79A 3eteA-1zbsA:
undetectable
3eteB-1zbsA:
undetectable		 3eteA-1zbsA:
20.63
3eteB-1zbsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a39 ENDOGLUCANASE I

(Humicola
insolens) 		PF00840
(Glyco_hydro_7) 		3 TYR A 167
TYR A  81
ILE A  78
 None
 0.81A 3eteA-2a39A:
undetectable
3eteB-2a39A:
undetectable		 3eteA-2a39A:
22.26
3eteB-2a39A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaa ALPHA-AMYLASE

(Aspergillus
niger) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		3 TYR A 352
TYR A  12
ILE A  52
 None
 0.69A 3eteA-2aaaA:
undetectable
3eteB-2aaaA:
undetectable		 3eteA-2aaaA:
22.78
3eteB-2aaaA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeg HYPOTHETICAL PROTEIN
AGR_PAT_140

(Agrobacterium
fabrum) 		PF02586
(SRAP) 		3 TYR A  30
TYR A 179
ILE A  40
 None
 0.64A 3eteA-2aegA:
undetectable
3eteB-2aegA:
undetectable		 3eteA-2aegA:
19.05
3eteB-2aegA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 TYR A 171
TYR A 271
ILE A 220
 None
 0.85A 3eteA-2b5mA:
undetectable
3eteB-2b5mA:
undetectable		 3eteA-2b5mA:
19.20
3eteB-2b5mA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 TYR A  70
TYR A 105
ILE A  76
 None
 0.83A 3eteA-2bucA:
undetectable
3eteB-2bucA:
undetectable		 3eteA-2bucA:
22.35
3eteB-2bucA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 TYR A 538
TYR A 560
ILE A 574
 None
 0.79A 3eteA-2erqA:
2.9
3eteB-2erqA:
2.8		 3eteA-2erqA:
21.32
3eteB-2erqA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		3 TYR A 113
TYR A 432
ILE A 431
 None
 0.81A 3eteA-2fgeA:
undetectable
3eteB-2fgeA:
undetectable		 3eteA-2fgeA:
19.74
3eteB-2fgeA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		3 TYR A 104
TYR A 163
ILE A 358
 None
 0.85A 3eteA-2i3oA:
undetectable
3eteB-2i3oA:
undetectable		 3eteA-2i3oA:
21.98
3eteB-2i3oA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3m PROLYL-TRNA
SYNTHETASE

(Enterococcus
faecalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		3 TYR A 133
TYR A 181
ILE A 443
 None
 0.62A 3eteA-2j3mA:
undetectable
3eteB-2j3mA:
undetectable		 3eteA-2j3mA:
20.96
3eteB-2j3mA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j67 TOLL LIKE RECEPTOR
10

(Homo sapiens) 		PF01582
(TIR) 		3 TYR A 668
TYR A 708
ILE A 682
 None
 0.67A 3eteA-2j67A:
undetectable
3eteB-2j67A:
undetectable		 3eteA-2j67A:
18.40
3eteB-2j67A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		3 TYR A 407
TYR A 337
ILE A 340
 None
 0.78A 3eteA-2jf7A:
undetectable
3eteB-2jf7A:
undetectable		 3eteA-2jf7A:
22.20
3eteB-2jf7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrt UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13905
(Thioredoxin_8) 		3 TYR A  72
TYR A 109
ILE A  16
 None
 0.77A 3eteA-2lrtA:
undetectable
3eteB-2lrtA:
undetectable		 3eteA-2lrtA:
14.77
3eteB-2lrtA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN

(Homo sapiens) 		PF01823
(MACPF) 		3 TYR A 422
TYR A 185
ILE A 116
 None
 0.84A 3eteA-2qqhA:
undetectable
3eteB-2qqhA:
undetectable		 3eteA-2qqhA:
21.31
3eteB-2qqhA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5r UPF0343 PROTEIN
NE1163

(Nitrosomonas
europaea) 		PF02649
(GCHY-1) 		3 TYR A 200
TYR A 126
ILE A 111
 None
 0.78A 3eteA-2r5rA:
undetectable
3eteB-2r5rA:
undetectable		 3eteA-2r5rA:
21.41
3eteB-2r5rA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2taa TAKA-AMYLASE A

(Aspergillus
oryzae) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		3 TYR A 352
TYR A  12
ILE A  52
 None
 0.82A 3eteA-2taaA:
undetectable
3eteB-2taaA:
undetectable		 3eteA-2taaA:
22.75
3eteB-2taaA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2

(Homo sapiens) 		PF00709
(Adenylsucc_synt) 		3 TYR A 300
TYR A 428
ILE A 372
 None
 0.76A 3eteA-2v40A:
undetectable
3eteB-2v40A:
undetectable		 3eteA-2v40A:
22.46
3eteB-2v40A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5c UNCHARACTERIZED
PROTEIN YLR021W

(Saccharomyces
cerevisiae) 		PF10448
(POC3_POC4) 		3 TYR B   4
TYR B 120
ILE B  38
 None
 0.70A 3eteA-2z5cB:
undetectable
3eteB-2z5cB:
undetectable		 3eteA-2z5cB:
15.10
3eteB-2z5cB:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djw ORF99

(Acidianus
filamentous
virus 1) 		PF07118
(DUF1374) 		3 TYR A  85
TYR A  61
ILE A  42
 None
 0.85A 3eteA-3djwA:
undetectable
3eteB-3djwA:
undetectable		 3eteA-3djwA:
12.32
3eteB-3djwA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Listeria
innocua) 		PF00155
(Aminotran_1_2) 		3 TYR A 325
TYR A 285
ILE A 353
 None
 0.72A 3eteA-3ffhA:
3.8
3eteB-3ffhA:
3.8		 3eteA-3ffhA:
22.33
3eteB-3ffhA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		3 TYR A  53
TYR A 394
ILE A 411
 None
 0.83A 3eteA-3fw6A:
undetectable
3eteB-3fw6A:
undetectable		 3eteA-3fw6A:
22.81
3eteB-3fw6A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 TYR A 182
TYR A 223
ILE A 179
 None
 0.80A 3eteA-3g25A:
undetectable
3eteB-3g25A:
undetectable		 3eteA-3g25A:
23.17
3eteB-3g25A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3l PUTATIVE SUGAR
HYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		3 TYR A 138
TYR A  67
ILE A 136
 None
 0.84A 3eteA-3h3lA:
undetectable
3eteB-3h3lA:
undetectable		 3eteA-3h3lA:
20.09
3eteB-3h3lA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		3 TYR A 127
TYR A 108
ILE A 124
 None
 0.78A 3eteA-3j04A:
0.9
3eteB-3j04A:
undetectable		 3eteA-3j04A:
20.41
3eteB-3j04A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jys SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TYR A 218
TYR A 261
ILE A 286
 None
 0.84A 3eteA-3jysA:
undetectable
3eteB-3jysA:
undetectable		 3eteA-3jysA:
21.38
3eteB-3jysA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		3 TYR A 240
TYR A 313
ILE A 293
 None
 0.77A 3eteA-3lscA:
undetectable
3eteB-3lscA:
undetectable		 3eteA-3lscA:
22.33
3eteB-3lscA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lur PUTATIVE BACTERIAL
TRANSCRIPTION
REGULATION PROTEIN

(Staphylococcus
aureus) 		PF06445
(GyrI-like) 		3 TYR A 137
TYR A  38
ILE A  43
 PG4  A 158 ( 3.8A)
PG4  A 158 (-4.6A)
None
 0.85A 3eteA-3lurA:
undetectable
3eteB-3lurA:
undetectable		 3eteA-3lurA:
15.49
3eteB-3lurA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 TYR A 206
TYR A 363
ILE A 367
 None
 0.70A 3eteA-3maxA:
undetectable
3eteB-3maxA:
undetectable		 3eteA-3maxA:
21.43
3eteB-3maxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0c THYMIDYLATE SYNTHASE
THYX

(Thermotoga
maritima) 		PF02511
(Thy1) 		3 TYR A  99
TYR A 186
ILE A   5
 None
 0.70A 3eteA-3n0cA:
undetectable
3eteB-3n0cA:
undetectable		 3eteA-3n0cA:
20.24
3eteB-3n0cA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea) 		PF05960
(DUF885) 		3 TYR A 384
TYR A 404
ILE A 448
 None
 0.81A 3eteA-3o0yA:
undetectable
3eteB-3o0yA:
undetectable		 3eteA-3o0yA:
22.24
3eteB-3o0yA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opx PROTEIN SSM1

(Saccharomyces
cerevisiae) 		PF13419
(HAD_2) 		3 TYR A  79
TYR A 100
ILE A  86
 U5P  A 265 (-4.7A)
None
None
 0.83A 3eteA-3opxA:
undetectable
3eteB-3opxA:
undetectable		 3eteA-3opxA:
18.92
3eteB-3opxA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5e ATLASTIN-1

(Homo sapiens) 		PF02263
(GBP) 		3 TYR A 196
TYR A 336
ILE A 335
 None
 0.74A 3eteA-3q5eA:
undetectable
3eteB-3q5eA:
undetectable		 3eteA-3q5eA:
23.21
3eteB-3q5eA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnk PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TYR A 319
TYR A 383
ILE A 305
 None
 0.79A 3eteA-3qnkA:
undetectable
3eteB-3qnkA:
undetectable		 3eteA-3qnkA:
23.54
3eteB-3qnkA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7t ADENYLOSUCCINATE
SYNTHETASE

(Campylobacter
jejuni) 		PF00709
(Adenylsucc_synt) 		3 TYR A 265
TYR A 389
ILE A 337
 None
 0.79A 3eteA-3r7tA:
undetectable
3eteB-3r7tA:
undetectable		 3eteA-3r7tA:
21.40
3eteB-3r7tA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7f UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7

(Saccharomyces
cerevisiae) 		PF16420
(ATG7_N) 		3 TYR A 228
TYR A 192
ILE A 117
 None
 0.85A 3eteA-3t7fA:
undetectable
3eteB-3t7fA:
undetectable		 3eteA-3t7fA:
19.05
3eteB-3t7fA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7b ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00331
(Glyco_hydro_10) 		3 TYR A 178
TYR A 243
ILE A 269
 EDO  A 402 (-3.7A)
None
None
 0.84A 3eteA-3u7bA:
undetectable
3eteB-3u7bA:
undetectable		 3eteA-3u7bA:
19.92
3eteB-3u7bA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs7 PYRIDOXAL KINASE

(Trypanosoma
brucei) 		PF08543
(Phos_pyr_kin) 		3 TYR A  84
TYR A 136
ILE A  91
 None
 0.67A 3eteA-3zs7A:
3.2
3eteB-3zs7A:
3.4		 3eteA-3zs7A:
19.67
3eteB-3zs7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 TYR A 217
TYR A 160
ILE A 161
 None
 0.74A 3eteA-3zz1A:
undetectable
3eteB-3zz1A:
2.8		 3eteA-3zz1A:
22.19
3eteB-3zz1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		3 TYR A  46
TYR A  76
ILE A  73
 None
IK2  A1435 (-4.6A)
None
 0.64A 3eteA-4aoaA:
undetectable
3eteB-4aoaA:
undetectable		 3eteA-4aoaA:
22.04
3eteB-4aoaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		3 TYR H 570
TYR H 703
ILE H 704
 None
 0.80A 3eteA-4c8qH:
undetectable
3eteB-4c8qH:
undetectable		 3eteA-4c8qH:
20.99
3eteB-4c8qH:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Mycoplasma
penetrans) 		PF00145
(DNA_methylase) 		3 TYR A 210
TYR A 131
ILE A 161
 None
 0.80A 3eteA-4dkjA:
3.3
3eteB-4dkjA:
3.1		 3eteA-4dkjA:
20.97
3eteB-4dkjA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im4 ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		3 TYR A 273
TYR A 362
ILE A 320
 None
 0.70A 3eteA-4im4A:
undetectable
3eteB-4im4A:
undetectable		 3eteA-4im4A:
21.17
3eteB-4im4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15892
(BNR_4) 		3 TYR A 257
TYR A 246
ILE A 250
 None
 0.83A 3eteA-4irtA:
undetectable
3eteB-4irtA:
undetectable		 3eteA-4irtA:
22.18
3eteB-4irtA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 TYR A 121
TYR A 107
ILE A 118
 None
 0.81A 3eteA-4jr7A:
undetectable
3eteB-4jr7A:
undetectable		 3eteA-4jr7A:
21.56
3eteB-4jr7A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lim DNA PRIMASE SMALL
SUBUNIT

(Saccharomyces
cerevisiae) 		PF01896
(DNA_primase_S) 		3 TYR A 190
TYR A 310
ILE A 143
 None
 0.77A 3eteA-4limA:
undetectable
3eteB-4limA:
undetectable		 3eteA-4limA:
23.08
3eteB-4limA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 TYR A 128
TYR A 109
ILE A 125
 None
 0.84A 3eteA-4pd3A:
undetectable
3eteB-4pd3A:
undetectable		 3eteA-4pd3A:
19.70
3eteB-4pd3A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 TYR B 138
TYR B  99
ILE B 128
 None
 0.72A 3eteA-4qiwB:
undetectable
3eteB-4qiwB:
undetectable		 3eteA-4qiwB:
18.84
3eteB-4qiwB:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		3 TYR A 426
TYR A 456
ILE A 367
 None
 0.85A 3eteA-4uhiA:
undetectable
3eteB-4uhiA:
undetectable		 3eteA-4uhiA:
20.99
3eteB-4uhiA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhy REPULSIVE GUIDANCE
MOLECULE A

(Homo sapiens) 		PF06535
(RGM_N) 		3 TYR C  99
TYR C  82
ILE C 106
 None
 0.81A 3eteA-4uhyC:
undetectable
3eteB-4uhyC:
undetectable		 3eteA-4uhyC:
13.67
3eteB-4uhyC:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ui0 RGM DOMAIN FAMILY
MEMBER B

(Homo sapiens) 		PF06535
(RGM_N) 		3 TYR C 105
TYR C  88
ILE C 112
 None
 0.84A 3eteA-4ui0C:
undetectable
3eteB-4ui0C:
undetectable		 3eteA-4ui0C:
12.65
3eteB-4ui0C:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ui2 REPULSIVE GUIDANCE
MOLECULE C, RGMC,
HEMOJUVELIN

(Homo sapiens) 		PF06535
(RGM_N) 		3 TYR C 105
TYR C  88
ILE C 112
 None
 0.79A 3eteA-4ui2C:
undetectable
3eteB-4ui2C:
undetectable		 3eteA-4ui2C:
13.46
3eteB-4ui2C:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		3 TYR A1267
TYR A1256
ILE A1274
 None
 0.63A 3eteA-4xqkA:
1.4
3eteB-4xqkA:
undetectable		 3eteA-4xqkA:
16.54
3eteB-4xqkA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 TYR A 411
TYR A 588
ILE A 611
 None
 0.46A 3eteA-4zohA:
undetectable
3eteB-4zohA:
undetectable		 3eteA-4zohA:
24.36
3eteB-4zohA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE

(Saccharophagus
degradans) 		PF00150
(Cellulase) 		3 TYR A 119
TYR A 175
ILE A 171
 None
 0.80A 3eteA-5a8qA:
undetectable
3eteB-5a8qA:
undetectable		 3eteA-5a8qA:
20.69
3eteB-5a8qA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		3 TYR A 853
TYR A 757
ILE A 719
 None
 0.81A 3eteA-5azaA:
undetectable
3eteB-5azaA:
undetectable		 3eteA-5azaA:
21.69
3eteB-5azaA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl5 MEMBRANE PROTEIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		3 TYR A 205
TYR A 289
ILE A 262
 None
 0.78A 3eteA-5dl5A:
undetectable
3eteB-5dl5A:
undetectable		 3eteA-5dl5A:
22.56
3eteB-5dl5A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 TYR A 171
TYR A 271
ILE A 220
 None
 0.78A 3eteA-5fqdA:
undetectable
3eteB-5fqdA:
undetectable		 3eteA-5fqdA:
21.26
3eteB-5fqdA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnb SPIKE GLYCOPROTEIN

(Human
coronavirus
HKU1) 		PF09408
(Spike_rec_bind) 		3 TYR A 627
TYR A 651
ILE A 657
 None
 0.84A 3eteA-5gnbA:
undetectable
3eteB-5gnbA:
undetectable		 3eteA-5gnbA:
19.61
3eteB-5gnbA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		3 TYR A 295
TYR A 283
ILE A 255
 None
 0.76A 3eteA-5gslA:
undetectable
3eteB-5gslA:
undetectable		 3eteA-5gslA:
21.47
3eteB-5gslA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		3 TYR A  35
TYR A  64
ILE A  29
 None
 0.77A 3eteA-5hkeA:
undetectable
3eteB-5hkeA:
undetectable		 3eteA-5hkeA:
21.48
3eteB-5hkeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		3 TYR A  64
TYR A 278
ILE A  68
 None
 0.68A 3eteA-5hkeA:
undetectable
3eteB-5hkeA:
undetectable		 3eteA-5hkeA:
21.48
3eteB-5hkeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsi PUTATIVE
DECARBOXYLASE

(Lactobacillus
brevis) 		PF00282
(Pyridoxal_deC) 		3 TYR A 435
TYR A 168
ILE A 405
 None
 0.78A 3eteA-5hsiA:
undetectable
3eteB-5hsiA:
2.2		 3eteA-5hsiA:
21.79
3eteB-5hsiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i33 ADENYLOSUCCINATE
SYNTHETASE

(Cryptococcus
neoformans) 		PF00709
(Adenylsucc_synt) 		3 TYR A 274
TYR A 402
ILE A 346
 None
 0.78A 3eteA-5i33A:
undetectable
3eteB-5i33A:
undetectable		 3eteA-5i33A:
21.88
3eteB-5i33A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 TYR A 148
TYR A 129
ILE A 145
 AOV  A1500 (-4.4A)
None
None
 0.76A 3eteA-5i4eA:
undetectable
3eteB-5i4eA:
0.8		 3eteA-5i4eA:
19.17
3eteB-5i4eA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT

(Pyrococcus
abyssi) 		PF00149
(Metallophos) 		3 TYR A 412
TYR A 163
ILE A 409
 None
 0.79A 3eteA-5iheA:
undetectable
3eteB-5iheA:
undetectable		 3eteA-5iheA:
22.77
3eteB-5iheA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12771
(SusD-like_2) 		3 TYR A  54
TYR A 140
ILE A 139
 None
 0.82A 3eteA-5j5uA:
undetectable
3eteB-5j5uA:
undetectable		 3eteA-5j5uA:
22.08
3eteB-5j5uA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 TYR A 380
TYR A 423
ILE A 386
 None
 0.85A 3eteA-5k8fA:
2.9
3eteB-5k8fA:
6.0		 3eteA-5k8fA:
22.46
3eteB-5k8fA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mul NEURAMINIDASE

(Bacteroides
thetaiotaomicron) 		PF15892
(BNR_4) 		3 TYR A 257
TYR A 246
ILE A 250
 None
 0.81A 3eteA-5mulA:
undetectable
3eteB-5mulA:
undetectable		 3eteA-5mulA:
23.13
3eteB-5mulA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvh BACCELL_00856

(Bacteroides
cellulosilyticus) 		PF15892
(BNR_4) 		3 TYR A 257
TYR A 246
ILE A 250
 None
 0.82A 3eteA-5mvhA:
undetectable
3eteB-5mvhA:
undetectable		 3eteA-5mvhA:
18.85
3eteB-5mvhA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7z LIPOPOLYSACCHARIDE
1,6-GALACTOSYLTRANSF
ERASE

(Salmonella
enterica) 		no annotation 3 TYR A 280
TYR A 341
ILE A 167
 None
 0.69A 3eteA-5n7zA:
2.0
3eteB-5n7zA:
undetectable		 3eteA-5n7zA:
9.88
3eteB-5n7zA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxy OSMOTICALLY
ACTIVATED
L-CARNITINE/CHOLINE
ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN OPUCC

(Bacillus
subtilis) 		no annotation 3 TYR A 143
TYR A 189
ILE A 171
 None
1Y8  A 301 (-3.5A)
None
 0.69A 3eteA-5nxyA:
2.3
3eteB-5nxyA:
2.5		 3eteA-5nxyA:
11.63
3eteB-5nxyA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj2 MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1

(Gallus gallus) 		PF13927
(Ig_3) 		3 TYR A 635
TYR A 652
ILE A 731
 None
 0.66A 3eteA-5oj2A:
undetectable
3eteB-5oj2A:
undetectable		 3eteA-5oj2A:
20.39
3eteB-5oj2A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 TYR A 557
TYR A 628
ILE A 577
 None
 0.83A 3eteA-5t98A:
undetectable
3eteB-5t98A:
undetectable		 3eteA-5t98A:
20.63
3eteB-5t98A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsc UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 3 TYR A 198
TYR A 192
ILE A 193
 None
 0.70A 3eteA-5tscA:
undetectable
3eteB-5tscA:
undetectable		 3eteA-5tscA:
21.92
3eteB-5tscA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucm PROLINE--TRNA LIGASE

(Pseudomonas
aeruginosa) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		3 TYR A 133
TYR A 181
ILE A 444
 None
 0.64A 3eteA-5ucmA:
undetectable
3eteB-5ucmA:
undetectable		 3eteA-5ucmA:
22.61
3eteB-5ucmA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Homo sapiens) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		3 TYR A 107
TYR A  49
ILE A  36
 None
 0.71A 3eteA-5ukwA:
undetectable
3eteB-5ukwA:
2.0		 3eteA-5ukwA:
23.76
3eteB-5ukwA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgr ATLASTIN-3

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		3 TYR A 192
TYR A 332
ILE A 331
 None
 0.75A 3eteA-5vgrA:
undetectable
3eteB-5vgrA:
1.9		 3eteA-5vgrA:
19.85
3eteB-5vgrA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y63 ALKYL HYDROPEROXIDE
REDUCTASE, C SUBUNIT

(Enterococcus
faecalis) 		no annotation 3 TYR A  39
TYR A  94
ILE A  92
 None
 0.85A 3eteA-5y63A:
undetectable
3eteB-5y63A:
undetectable		 3eteA-5y63A:
9.54
3eteB-5y63A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeu -

(-) 		no annotation 3 TYR A 339
TYR A 233
ILE A 336
 None
 0.78A 3eteA-5yeuA:
undetectable
3eteB-5yeuA:
undetectable		 3eteA-5yeuA:
undetectable
3eteB-5yeuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 3 TYR I 154
TYR I 340
ILE I  18
 None
 0.81A 3eteA-6esqI:
undetectable
3eteB-6esqI:
undetectable		 3eteA-6esqI:
10.84
3eteB-6esqI:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ewp CENTROSOMAL PROTEIN
OF 120 KDA

(Mus musculus) 		no annotation 3 TYR A 512
TYR A 481
ILE A 492
 None
 0.77A 3eteA-6ewpA:
undetectable
3eteB-6ewpA:
undetectable		 3eteA-6ewpA:
10.08
3eteB-6ewpA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE

(Staphylococcus
hominis) 		no annotation 3 TYR A 397
TYR A 320
ILE A 390
 OLC  A 505 ( 3.7A)
None
None
 0.84A 3eteA-6exsA:
undetectable
3eteB-6exsA:
undetectable		 3eteA-6exsA:
10.71
3eteB-6exsA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6flk CEP120

(Homo sapiens) 		no annotation 3 TYR A 509
TYR A 478
ILE A 489
 None
 0.78A 3eteA-6flkA:
undetectable
3eteB-6flkA:
undetectable		 3eteA-6flkA:
9.21
3eteB-6flkA:
9.21