SIMILAR PATTERNS OF AMINO ACIDS FOR 3ETE_A_H3PA552_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1btc BETA-AMYLASE

(Glycine max) 		PF01373
(Glyco_hydro_14) 		4 ILE A 121
TYR A 134
ILE A 153
HIS A 146
 None
 1.06A 3eteA-1btcA:
undetectable
3eteE-1btcA:
undetectable		 3eteA-1btcA:
21.58
3eteE-1btcA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dct PROTEIN
(MODIFICATION
METHYLASE HAEIII)

(Haemophilus
influenzae) 		PF00145
(DNA_methylase) 		4 ILE A  95
TYR A 135
LYS A 102
ILE A  97
 None
 1.13A 3eteA-1dctA:
3.7
3eteE-1dctA:
3.8		 3eteA-1dctA:
22.52
3eteE-1dctA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ft9 CARBON MONOXIDE
OXIDATION SYSTEM
TRANSCRIPTION
REGULATOR

(Rhodospirillum
rubrum) 		PF13545
(HTH_Crp_2) 		4 ILE A 139
TYR A 192
ILE A 144
HIS A 146
 None
 1.06A 3eteA-1ft9A:
undetectable
3eteE-1ft9A:
undetectable		 3eteA-1ft9A:
18.33
3eteE-1ft9A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggp PROTEIN (LECTIN 1 A
CHAIN)

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		4 ILE A 127
TYR A 113
MET A 161
ILE A 158
 None
 1.13A 3eteA-1ggpA:
undetectable
3eteE-1ggpA:
undetectable		 3eteA-1ggpA:
20.58
3eteE-1ggpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkx CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Mus musculus) 		PF08332
(CaMKII_AD) 		4 ILE A 350
TYR A 431
ILE A 464
HIS A 456
 None
 0.81A 3eteA-1hkxA:
undetectable
3eteE-1hkxA:
undetectable		 3eteA-1hkxA:
14.97
3eteE-1hkxA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuu ACETATE KINASE

(Methanosarcina
thermophila) 		PF00871
(Acetate_kinase) 		4 ILE A 388
TYR A 186
MET A  20
ILE A  18
 None
 1.22A 3eteA-1tuuA:
undetectable
3eteE-1tuuA:
undetectable		 3eteA-1tuuA:
24.31
3eteE-1tuuA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		4 ILE A   4
TYR A 275
ILE A 233
HIS A 244
 None
 1.18A 3eteA-1xp3A:
undetectable
3eteE-1xp3A:
undetectable		 3eteA-1xp3A:
20.76
3eteE-1xp3A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y17 ANTICOAGULANT
PROTEIN A

(Deinagkistrodon
acutus) 		PF00059
(Lectin_C) 		4 ILE A  55
TYR A  14
ILE A  68
HIS A  65
 None
 0.97A 3eteA-1y17A:
undetectable
3eteE-1y17A:
undetectable		 3eteA-1y17A:
13.08
3eteE-1y17A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ILE A 824
TYR A 687
ILE A 715
HIS A 788
 None
 1.17A 3eteA-1yguA:
undetectable
3eteE-1yguA:
undetectable		 3eteA-1yguA:
23.60
3eteE-1yguA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq9 PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
gigas) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ILE A  95
TYR A  93
ILE A  72
HIS A  13
 None
 1.03A 3eteA-1yq9A:
undetectable
3eteE-1yq9A:
undetectable		 3eteA-1yq9A:
19.68
3eteE-1yq9A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1) 		4 ILE A 250
LYS A 152
ILE A 192
HIS A 258
 None
 1.21A 3eteA-2d5rA:
undetectable
3eteE-2d5rA:
undetectable		 3eteA-2d5rA:
19.60
3eteE-2d5rA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejc PANTOATE--BETA-ALANI
NE LIGASE

(Thermotoga
maritima) 		PF02569
(Pantoate_ligase) 		4 ILE A   7
LYS A  12
ILE A   4
HIS A  92
 ZN  A 501 ( 4.9A)
None
None
ZN  A 503 (-3.5A)
 1.02A 3eteA-2ejcA:
undetectable
3eteE-2ejcA:
undetectable		 3eteA-2ejcA:
21.80
3eteE-2ejcA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9z PROTEIN (CHEMOTAXIS
METHYLATION PROTEIN)

(Thermotoga
maritima) 		PF03975
(CheD) 		4 ILE C  86
TYR C 134
ILE C 117
HIS C 111
 None
 1.12A 3eteA-2f9zC:
2.7
3eteE-2f9zC:
2.7		 3eteA-2f9zC:
18.71
3eteE-2f9zC:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhx SPM-1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 ILE B 260
MET B 299
ILE B 223
HIS B 263
 None
None
None
CSO  B 221 (-3.5A)
 1.09A 3eteA-2fhxB:
undetectable
3eteE-2fhxB:
undetectable		 3eteA-2fhxB:
19.50
3eteE-2fhxB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		4 ILE A 624
TYR A 599
MET A 528
ILE A 519
 None
TDK  A 887 (-4.3A)
None
None
 1.20A 3eteA-2g28A:
3.1
3eteE-2g28A:
2.4		 3eteA-2g28A:
21.87
3eteE-2g28A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf0 GTP-BINDING PROTEIN
DI-RAS1

(Homo sapiens) 		PF00071
(Ras) 		4 ILE A  76
TYR A 101
ILE A 114
HIS A  80
 None
 0.97A 3eteA-2gf0A:
undetectable
3eteE-2gf0A:
undetectable		 3eteA-2gf0A:
16.97
3eteE-2gf0A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ILE A   8
MET A 490
ILE A 486
HIS A  65
 None
 1.19A 3eteA-2ifyA:
undetectable
3eteE-2ifyA:
undetectable		 3eteA-2ifyA:
21.49
3eteE-2ifyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iir ACETATE KINASE

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		4 ILE A 390
TYR A 185
MET A  20
ILE A  18
 None
 1.05A 3eteA-2iirA:
2.1
3eteE-2iirA:
2.0		 3eteA-2iirA:
23.20
3eteE-2iirA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		4 ILE A  20
TYR A  22
ILE A  11
HIS A  89
 None
 1.11A 3eteA-2jjyA:
4.3
3eteE-2jjyA:
4.2		 3eteA-2jjyA:
20.97
3eteE-2jjyA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2klx GLUTAREDOXIN

(Bartonella
henselae) 		PF00462
(Glutaredoxin) 		4 ILE A   5
TYR A  29
ILE A  55
HIS A  61
 None
 1.12A 3eteA-2klxA:
undetectable
3eteE-2klxA:
undetectable		 3eteA-2klxA:
13.96
3eteE-2klxA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lns ANTERIOR GRADIENT
PROTEIN 2 HOMOLOG

(Homo sapiens) 		PF13899
(Thioredoxin_7) 		4 ILE A  74
MET A 164
ILE A 128
HIS A  77
 None
 1.15A 3eteA-2lnsA:
undetectable
3eteE-2lnsA:
undetectable		 3eteA-2lnsA:
15.73
3eteE-2lnsA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lv3 THIOREDOXIN
REDUCTASE 3

(Mus musculus) 		PF00462
(Glutaredoxin) 		4 ILE A  86
MET A  41
ILE A  35
HIS A 101
 None
 1.19A 3eteA-2lv3A:
undetectable
3eteE-2lv3A:
undetectable		 3eteA-2lv3A:
13.24
3eteE-2lv3A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Shigella
flexneri) 		PF03009
(GDPD) 		4 ILE A  27
LYS A  32
ILE A 237
HIS A  12
 None
None
None
PO4  A 301 (-4.0A)
 1.02A 3eteA-2otdA:
undetectable
3eteE-2otdA:
undetectable		 3eteA-2otdA:
18.45
3eteE-2otdA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00215
(OMPdecase) 		4 ILE A 250
MET A  58
ILE A 257
HIS A 225
 None
 1.21A 3eteA-2p1fA:
undetectable
3eteE-2p1fA:
undetectable		 3eteA-2p1fA:
23.35
3eteE-2p1fA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I

(Escherichia
coli) 		PF00365
(PFK) 		4 ILE A  81
TYR A  41
MET A 115
ILE A  86
 None
 1.21A 3eteA-2pfkA:
2.8
3eteE-2pfkA:
2.7		 3eteA-2pfkA:
20.91
3eteE-2pfkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 ILE A 102
MET A  40
ILE A  44
HIS A 111
 None
None
None
EDO  A 295 (-3.8A)
 1.01A 3eteA-2r9lA:
undetectable
3eteE-2r9lA:
undetectable		 3eteA-2r9lA:
22.18
3eteE-2r9lA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF01276
(OKR_DC_1)
PF03711
(OKR_DC_1_C) 		4 ILE A 176
TYR A 204
ILE A  99
HIS A 121
 None
 1.13A 3eteA-2x3lA:
2.3
3eteE-2x3lA:
2.5		 3eteA-2x3lA:
23.05
3eteE-2x3lA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz4 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 TYR A 191
MET A 213
ILE A  86
HIS A 196
 None
None
None
EDO  A 601 (-4.5A)
 1.05A 3eteA-2xz4A:
undetectable
3eteE-2xz4A:
undetectable		 3eteA-2xz4A:
17.94
3eteE-2xz4A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA

(Methanocaldococcus
jannaschii) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 ILE A 281
MET A 155
ILE A 170
HIS A 168
 None
 1.08A 3eteA-2yv1A:
7.1
3eteE-2yv1A:
6.2		 3eteA-2yv1A:
21.41
3eteE-2yv1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxj TRANSCRIPTIONAL
REGULATORY PROTEIN
WALR

(Staphylococcus
aureus) 		PF00486
(Trans_reg_C) 		4 ILE A 137
LYS A 151
ILE A 149
HIS A 167
 None
 1.18A 3eteA-2zxjA:
undetectable
3eteE-2zxjA:
undetectable		 3eteA-2zxjA:
14.86
3eteE-2zxjA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 ILE A 295
TYR A 242
ILE A 180
HIS A 213
 None
None
None
HTL  A 827 ( 4.3A)
 1.05A 3eteA-3ahiA:
undetectable
3eteE-3ahiA:
undetectable		 3eteA-3ahiA:
21.10
3eteE-3ahiA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9d ZGC:56074

(Danio rerio) 		PF00300
(His_Phos_1) 		4 ILE A  68
MET A  81
ILE A  63
HIS A  11
 None
None
None
PO4  A 266 (-4.0A)
 1.14A 3eteA-3e9dA:
undetectable
3eteE-3e9dA:
undetectable		 3eteA-3e9dA:
19.68
3eteE-3e9dA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ea0 ATPASE, PARA FAMILY

(Chlorobaculum
tepidum) 		PF13614
(AAA_31) 		4 ILE A 111
TYR A 116
MET A  77
ILE A  62
 None
 1.17A 3eteA-3ea0A:
undetectable
3eteE-3ea0A:
undetectable		 3eteA-3ea0A:
20.24
3eteE-3ea0A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edi TOLLOID-LIKE PROTEIN
1

(Homo sapiens) 		PF01400
(Astacin) 		4 ILE A  77
TYR A  17
MET A  29
HIS A  92
 None
DMS  A 215 (-4.3A)
None
ZN  A 210 (-3.2A)
 1.07A 3eteA-3ediA:
undetectable
3eteE-3ediA:
undetectable		 3eteA-3ediA:
18.84
3eteE-3ediA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		4 ILE A 259
TYR A 309
ILE A 266
HIS A 264
 None
 1.14A 3eteA-3f41A:
undetectable
3eteE-3f41A:
undetectable		 3eteA-3f41A:
22.60
3eteE-3f41A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ruegeria
pomeroyi) 		PF03480
(DctP) 		4 ILE A 194
TYR A 190
MET A 264
ILE A 201
 None
 1.10A 3eteA-3fxbA:
undetectable
3eteE-3fxbA:
undetectable		 3eteA-3fxbA:
20.48
3eteE-3fxbA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		4 ILE A  59
MET A 155
ILE A 106
HIS A 108
 None
 1.14A 3eteA-3gs6A:
undetectable
3eteE-3gs6A:
undetectable		 3eteA-3gs6A:
20.70
3eteE-3gs6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ILE A  38
TYR A  76
ILE A  35
HIS A  11
 None
 1.11A 3eteA-3hkoA:
undetectable
3eteE-3hkoA:
undetectable		 3eteA-3hkoA:
21.83
3eteE-3hkoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibx PUTATIVE THIAMINASE
II

(Helicobacter
pylori) 		PF03070
(TENA_THI-4) 		4 ILE A  14
TYR A   8
ILE A  19
HIS A  21
 None
 0.87A 3eteA-3ibxA:
undetectable
3eteE-3ibxA:
undetectable		 3eteA-3ibxA:
18.04
3eteE-3ibxA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipw HYDROLASE TATD
FAMILY PROTEIN

(Entamoeba
histolytica) 		PF01026
(TatD_DNase) 		4 ILE A 221
MET A 211
ILE A 195
HIS A 176
 None
 1.04A 3eteA-3ipwA:
undetectable
3eteE-3ipwA:
undetectable		 3eteA-3ipwA:
19.92
3eteE-3ipwA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		4 ILE A 675
TYR A 720
ILE A 701
HIS A 696
 None
 1.18A 3eteA-3j9dA:
undetectable
3eteE-3j9dA:
undetectable		 3eteA-3j9dA:
20.02
3eteE-3j9dA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb6 D-LACTATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A  78
TYR A  82
ILE A  46
HIS A  69
 None
 1.09A 3eteA-3kb6A:
10.9
3eteE-3kb6A:
10.9		 3eteA-3kb6A:
20.56
3eteE-3kb6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbq PROTEIN TA0487

(Thermoplasma
acidophilum) 		PF00994
(MoCF_biosynth) 		4 ILE A  25
TYR A  34
MET A 161
ILE A 145
 None
 1.16A 3eteA-3kbqA:
3.5
3eteE-3kbqA:
3.5		 3eteA-3kbqA:
17.37
3eteE-3kbqA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH

(Thermotoga
maritima) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		4 ILE E 582
LYS E 589
ILE E 445
HIS E 423
 None
None
None
ZN  E 996 ( 3.3A)
 1.11A 3eteA-3kdsE:
undetectable
3eteE-3kdsE:
undetectable		 3eteA-3kdsE:
23.43
3eteE-3kdsE:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 TYR A 138
MET A 118
ILE A 147
HIS A 189
 None
 1.15A 3eteA-3m07A:
undetectable
3eteE-3m07A:
undetectable		 3eteA-3m07A:
22.51
3eteE-3m07A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orw PHOSPHOTRIESTERASE

(Geobacillus
kaustophilus) 		PF02126
(PTE) 		4 ILE A 204
TYR A 225
ILE A 176
HIS A 178
 None
None
None
CO  A 328 (-3.3A)
 1.12A 3eteA-3orwA:
undetectable
3eteE-3orwA:
undetectable		 3eteA-3orwA:
22.87
3eteE-3orwA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1x SERINE
ACETYLTRANSFERASE

(Entamoeba
histolytica) 		PF00132
(Hexapep) 		4 ILE A 164
TYR A 136
ILE A 198
HIS A 180
 None
 1.20A 3eteA-3q1xA:
undetectable
3eteE-3q1xA:
undetectable		 3eteA-3q1xA:
20.87
3eteE-3q1xA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		4 ILE A 163
LYS A 139
ILE A 151
HIS A 153
 None
 1.09A 3eteA-3qfwA:
undetectable
3eteE-3qfwA:
undetectable		 3eteA-3qfwA:
21.83
3eteE-3qfwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr3 MICROCIN IMMUNITY
PROTEIN MCCF

(Bacillus
anthracis) 		PF02016
(Peptidase_S66) 		4 ILE A 231
MET A 310
ILE A 327
HIS A 326
 None
 1.16A 3eteA-3sr3A:
3.6
3eteE-3sr3A:
3.6		 3eteA-3sr3A:
22.04
3eteE-3sr3A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 4 ILE A 215
TYR A 222
MET A 201
ILE A 137
 None
None
None
FMT  A 360 (-4.6A)
 1.16A 3eteA-3tdgA:
undetectable
3eteE-3tdgA:
undetectable		 3eteA-3tdgA:
20.44
3eteE-3tdgA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqq METHIONYL-TRNA
FORMYLTRANSFERASE

(Coxiella
burnetii) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 ILE A 273
MET A 244
ILE A 246
HIS A 283
 None
 1.06A 3eteA-3tqqA:
3.0
3eteE-3tqqA:
3.3		 3eteA-3tqqA:
21.27
3eteE-3tqqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 433
LYS A 444
ILE A 371
HIS A 368
 None
 1.20A 3eteA-3vf1A:
undetectable
3eteE-3vf1A:
undetectable		 3eteA-3vf1A:
22.41
3eteE-3vf1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		4 ILE A 197
TYR A 219
ILE A 138
HIS A 142
 None
 0.94A 3eteA-3wrfA:
undetectable
3eteE-3wrfA:
undetectable		 3eteA-3wrfA:
22.92
3eteE-3wrfA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 ILE A 407
TYR A 386
ILE A 373
HIS A 284
 None
 1.13A 3eteA-4a2wA:
undetectable
3eteE-4a2wA:
undetectable		 3eteA-4a2wA:
19.67
3eteE-4a2wA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cq1 POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 2

(Homo sapiens) 		PF00076
(RRM_1)
PF13893
(RRM_5) 		4 ILE A 380
TYR A 362
MET A 400
ILE A 405
 None
 1.13A 3eteA-4cq1A:
undetectable
3eteE-4cq1A:
undetectable		 3eteA-4cq1A:
18.65
3eteE-4cq1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A

(Homo sapiens) 		PF01201
(Ribosomal_S8e) 		4 ILE i 526
MET i 334
ILE i 529
HIS i 531
 None
 1.18A 3eteA-4d61i:
undetectable
3eteE-4d61i:
undetectable		 3eteA-4d61i:
23.86
3eteE-4d61i:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db1 MYOSIN-7

(Homo sapiens) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 ILE A 313
TYR A 283
ILE A 356
HIS A 358
 None
 0.98A 3eteA-4db1A:
undetectable
3eteE-4db1A:
undetectable		 3eteA-4db1A:
20.72
3eteE-4db1A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF01746
(tRNA_m1G_MT) 		4 ILE A 227
TYR A 203
LYS A 201
ILE A 178
 None
 1.19A 3eteA-4fmwA:
undetectable
3eteE-4fmwA:
undetectable		 3eteA-4fmwA:
16.30
3eteE-4fmwA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 ILE A 484
TYR A 454
ILE A 441
HIS A 346
 None
 1.08A 3eteA-4gl2A:
undetectable
3eteE-4gl2A:
undetectable		 3eteA-4gl2A:
22.27
3eteE-4gl2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF02811
(PHP) 		4 ILE A 107
TYR A  99
ILE A 110
HIS A  53
 None
 0.95A 3eteA-4gx8A:
undetectable
3eteE-4gx8A:
undetectable		 3eteA-4gx8A:
20.72
3eteE-4gx8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxr MALONYL COA
SYNTHETASE,
BENZOATE-COA LIGASE
CHIMERIC PROTEIN

(Paraburkholderia
xenovorans;
Rhodopseudomonas
palustris) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 274
TYR A 313
MET A 270
HIS A 201
 None
None
None
MLY  A  62 ( 3.6A)
 1.15A 3eteA-4gxrA:
4.4
3eteE-4gxrA:
4.5		 3eteA-4gxrA:
22.98
3eteE-4gxrA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6v AMIDOHYDROLASE 2

(Planctopirus
limnophila) 		PF02614
(UxaC) 		4 ILE A 316
LYS A 367
ILE A 369
HIS A  25
 None
None
None
ZN  A 501 (-3.4A)
 0.90A 3eteA-4i6vA:
undetectable
3eteE-4i6vA:
undetectable		 3eteA-4i6vA:
22.81
3eteE-4i6vA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE

(Lactobacillus
rhamnosus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 ILE A 346
MET A 375
ILE A 446
HIS A 477
 None
None
None
ZN  A 701 ( 3.2A)
 0.92A 3eteA-4iuwA:
undetectable
3eteE-4iuwA:
undetectable		 3eteA-4iuwA:
21.68
3eteE-4iuwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 ILE A 586
TYR A 573
LYS A 560
ILE A 556
 None
 1.12A 3eteA-4ktpA:
undetectable
3eteE-4ktpA:
undetectable		 3eteA-4ktpA:
21.72
3eteE-4ktpA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 ILE A 276
TYR A 224
MET A 229
ILE A 269
 None
 1.04A 3eteA-4l87A:
undetectable
3eteE-4l87A:
undetectable		 3eteA-4l87A:
21.35
3eteE-4l87A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		4 ILE A 313
TYR A 283
ILE A 356
HIS A 358
 None
 0.98A 3eteA-4p7hA:
undetectable
3eteE-4p7hA:
undetectable		 3eteA-4p7hA:
19.14
3eteE-4p7hA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdd 3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE

(Rhodococcus
rhodochrous) 		PF00355
(Rieske) 		4 ILE A 178
TYR A 278
ILE A 170
HIS A 174
 None
 1.20A 3eteA-4qddA:
undetectable
3eteE-4qddA:
undetectable		 3eteA-4qddA:
22.10
3eteE-4qddA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlx NITROREDUCTASE
FAMILY PROTEIN

(Lactobacillus
plantarum) 		PF00881
(Nitroreductase) 		4 ILE A  88
TYR A  79
MET A 175
ILE A 170
 None
 1.07A 3eteA-4qlxA:
undetectable
3eteE-4qlxA:
undetectable		 3eteA-4qlxA:
18.84
3eteE-4qlxA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM3

(Methanocaldococcus
jannaschii) 		PF03787
(RAMPs) 		4 ILE C  48
TYR C 112
ILE C  41
HIS C  23
 None
 1.15A 3eteA-4qtsC:
undetectable
3eteE-4qtsC:
undetectable		 3eteA-4qtsC:
19.84
3eteE-4qtsC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 ILE A 380
TYR A 292
ILE A 276
HIS A 383
 None
 1.21A 3eteA-4yhjA:
undetectable
3eteE-4yhjA:
undetectable		 3eteA-4yhjA:
20.71
3eteE-4yhjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase) 		4 ILE A 374
MET A 356
ILE A 333
HIS A 335
 None
 1.15A 3eteA-4zcfA:
undetectable
3eteE-4zcfA:
undetectable		 3eteA-4zcfA:
21.50
3eteE-4zcfA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I

(Oryctolagus
cuniculus) 		PF00400
(WD40) 		4 ILE I 253
TYR I 234
LYS I 280
ILE I 286
 None
 1.14A 3eteA-5a5uI:
undetectable
3eteE-5a5uI:
undetectable		 3eteA-5a5uI:
22.20
3eteE-5a5uI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amp CELLOBIOHYDROLASE I

(Galactomyces
candidus) 		PF00840
(Glyco_hydro_7) 		4 ILE A 426
TYR A 423
MET A 146
ILE A 215
 None
 1.19A 3eteA-5ampA:
undetectable
3eteE-5ampA:
undetectable		 3eteA-5ampA:
20.68
3eteE-5ampA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		4 ILE A 545
TYR A 418
MET A 516
ILE A 548
 None
 1.04A 3eteA-5e31A:
undetectable
3eteE-5e31A:
undetectable		 3eteA-5e31A:
21.95
3eteE-5e31A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fim YGAU

(Escherichia
coli) 		PF01476
(LysM)
PF04972
(BON) 		4 ILE A  48
LYS A  54
ILE A  80
HIS A  34
 None
 1.21A 3eteA-5fimA:
undetectable
3eteE-5fimA:
undetectable		 3eteA-5fimA:
17.92
3eteE-5fimA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ILE A 455
TYR A  71
ILE A 463
HIS A 464
 None
 1.21A 3eteA-5g2vA:
undetectable
3eteE-5g2vA:
undetectable		 3eteA-5g2vA:
20.62
3eteE-5g2vA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 ILE A 652
TYR A 698
ILE A 654
HIS A 659
 None
 1.05A 3eteA-5h42A:
undetectable
3eteE-5h42A:
undetectable		 3eteA-5h42A:
19.43
3eteE-5h42A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum) 		PF04097
(Nic96) 		4 ILE A 726
TYR A 728
ILE A 440
HIS A 739
 None
 1.19A 3eteA-5hb3A:
undetectable
3eteE-5hb3A:
undetectable		 3eteA-5hb3A:
21.18
3eteE-5hb3A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA

(Homo sapiens) 		PF08332
(CaMKII_AD) 		4 ILE A 350
TYR A 431
ILE A 464
HIS A 456
 None
 0.81A 3eteA-5ig3A:
undetectable
3eteE-5ig3A:
undetectable		 3eteA-5ig3A:
15.95
3eteE-5ig3A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1b CELL WALL ASSEMBLY
REGULATOR SMI1

(Saccharomyces
cerevisiae) 		PF09346
(SMI1_KNR4) 		4 ILE A 264
TYR A 261
ILE A 238
HIS A 248
 None
 1.16A 3eteA-5j1bA:
undetectable
3eteE-5j1bA:
undetectable		 3eteA-5j1bA:
20.65
3eteE-5j1bA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 ILE A 476
TYR A 446
ILE A 433
HIS A 339
 None
 1.10A 3eteA-5jcfA:
undetectable
3eteE-5jcfA:
undetectable		 3eteA-5jcfA:
21.36
3eteE-5jcfA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kj2 HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF08214
(HAT_KAT11) 		4 ILE A1479
TYR A1421
ILE A1598
HIS A1481
 None
 1.22A 3eteA-5kj2A:
2.6
3eteE-5kj2A:
undetectable		 3eteA-5kj2A:
23.32
3eteE-5kj2A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		4 ILE A1479
TYR A1421
ILE A1598
HIS A1481
 None
 1.18A 3eteA-5lkzA:
2.8
3eteE-5lkzA:
undetectable		 3eteA-5lkzA:
22.06
3eteE-5lkzA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PUTATIVE PRE-MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		PF08084
(PROCT) 		4 ILE B2088
MET B2079
LYS B2081
ILE B2083
 None
 1.21A 3eteA-5m59B:
undetectable
3eteE-5m59B:
undetectable		 3eteA-5m59B:
20.56
3eteE-5m59B:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens) 		no annotation 4 ILE C 109
TYR C 107
ILE C  76
HIS C  44
 None
 1.14A 3eteA-5mg5C:
undetectable
3eteE-5mg5C:
undetectable		 3eteA-5mg5C:
10.85
3eteE-5mg5C:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n05 AUXILIARY ACTIVITY 9

(Lentinus
similis) 		PF03443
(Glyco_hydro_61) 		4 ILE A  82
TYR A  85
ILE A 144
HIS A  78
 None
None
None
CU  A 301 ( 3.2A)
 1.12A 3eteA-5n05A:
undetectable
3eteE-5n05A:
undetectable		 3eteA-5n05A:
18.04
3eteE-5n05A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nth PUTATIVE
AMINOPEPTIDASE

(Leishmania
major) 		PF00883
(Peptidase_M17) 		4 ILE A 264
TYR A 401
ILE A 251
HIS A 276
 None
 1.17A 3eteA-5nthA:
2.5
3eteE-5nthA:
2.3		 3eteA-5nthA:
23.57
3eteE-5nthA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		4 ILE A 129
TYR A 531
ILE A 123
HIS A 171
 None
 1.06A 3eteA-5tr1A:
undetectable
3eteE-5tr1A:
undetectable		 3eteA-5tr1A:
21.47
3eteE-5tr1A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1a MYOSIN HEAVY CHAIN,
MUSCLE

(Drosophila
melanogaster) 		no annotation 4 ILE A 193
TYR A 195
ILE A 456
HIS A 250
 None
 1.22A 3eteA-5w1aA:
undetectable
3eteE-5w1aA:
undetectable		 3eteA-5w1aA:
11.66
3eteE-5w1aA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yzc GLYCOPROTEIN
F1,MEASLES VIRUS
FUSION PROTEIN
GLYCOPROTEIN F2

(Measles
morbillivirus) 		no annotation 4 ILE A  62
TYR B 181
MET B 190
ILE B 187
 None
 1.21A 3eteA-5yzcA:
undetectable
3eteE-5yzcA:
undetectable		 3eteA-5yzcA:
9.96
3eteE-5yzcA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 4 ILE A  15
MET A 337
ILE A 335
HIS A 353
 None
 0.96A 3eteA-5za2A:
undetectable
3eteE-5za2A:
undetectable		 3eteA-5za2A:
11.33
3eteE-5za2A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zcs TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Homo sapiens) 		no annotation 4 ILE C 173
MET C 185
ILE C 144
HIS C 153
 None
 1.03A 3eteA-5zcsC:
undetectable
3eteE-5zcsC:
undetectable		 3eteA-5zcsC:
12.09
3eteE-5zcsC:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 ILE A 117
MET A 159
ILE A 147
HIS A 293
 None
 0.94A 3eteA-5ze4A:
2.6
3eteE-5ze4A:
2.6		 3eteA-5ze4A:
undetectable
3eteE-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b8d ELONGATION FACTOR G

(Haemophilus
influenzae) 		no annotation 4 ILE A 292
TYR A 133
ILE A 295
HIS A 308
 None
 1.21A 3eteA-6b8dA:
undetectable
3eteE-6b8dA:
undetectable		 3eteA-6b8dA:
21.80
3eteE-6b8dA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blj SERINE-TRNA LIGASE

(Naegleria
fowleri) 		no annotation 4 ILE A 280
TYR A 237
MET A 242
ILE A 273
 None
 1.10A 3eteA-6bljA:
undetectable
3eteE-6bljA:
undetectable		 3eteA-6bljA:
10.23
3eteE-6bljA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0f RIBOSOME PRODUCTION
FACTOR 1

(Saccharomyces
cerevisiae) 		no annotation 4 ILE I 140
LYS I 133
ILE I 274
HIS I 164
 None
 1.15A 3eteA-6c0fI:
undetectable
3eteE-6c0fI:
undetectable		 3eteA-6c0fI:
8.54
3eteE-6c0fI:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 ILE A 552
MET A 420
LYS A 423
ILE A 425
 None
 0.94A 3eteA-6cgmA:
undetectable
3eteE-6cgmA:
undetectable		 3eteA-6cgmA:
10.06
3eteE-6cgmA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cu5 PROTEIN ARGININE
N-METHYLTRANSFERASE

(Naegleria
fowleri) 		no annotation 4 ILE A  56
TYR A  90
LYS A  63
ILE A  35
 None
 1.14A 3eteA-6cu5A:
3.6
3eteE-6cu5A:
undetectable		 3eteA-6cu5A:
8.84
3eteE-6cu5A:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-) 		no annotation 4 ILE A 313
TYR A 283
ILE A 356
HIS A 358
 None
 1.10A 3eteA-6fsaA:
undetectable
3eteE-6fsaA:
undetectable		 3eteA-6fsaA:
undetectable
3eteE-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 4 ILE A 185
TYR A 175
ILE A  30
HIS A  29
 None
 1.14A 3eteA-6gneA:
2.9
3eteE-6gneA:
2.7		 3eteA-6gneA:
undetectable
3eteE-6gneA:
undetectable