SIMILAR PATTERNS OF AMINO ACIDS FOR 3ERD_A_DESA600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg3 DYSTROPHIN

(Homo sapiens) 		PF00397
(WW)
PF09068
(EF-hand_2)
PF09069
(EF-hand_3) 		5 LEU A 148
LEU A 179
LEU A  53
ARG A  63
HIS A 136
 None
 1.17A 3erdA-1eg3A:
undetectable		 3erdA-1eg3A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		5 ALA A 212
GLU A 191
LEU A 298
ARG A 186
LEU A 223
 None
 1.20A 3erdA-1g0vA:
undetectable		 3erdA-1g0vA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		5 LEU A 353
ALA A 383
LEU A 403
LEU A 361
LEU A 371
 None
 1.06A 3erdA-1gl6A:
undetectable		 3erdA-1gl6A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwi CYTOCHROME P450
154C1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 MET A 160
LEU A 213
ALA A 216
MET A 239
MET A 198
 None
None
None
HEM  A1414 (-4.3A)
None
 1.16A 3erdA-1gwiA:
undetectable		 3erdA-1gwiA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hus RIBOSOMAL PROTEIN S7

(Geobacillus
stearothermophilus) 		PF00177
(Ribosomal_S7) 		5 MET A  58
LEU A 100
LEU A 103
LEU A 119
LEU A  21
 None
 1.22A 3erdA-1husA:
undetectable		 3erdA-1husA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1c CATABOLITE
REPRESSION HPR-LIKE
PROTEIN

(Bacillus
subtilis) 		PF00381
(PTS-HPr) 		5 LEU A  77
GLU A  84
LEU A  14
LEU A  21
LEU A  35
 None
 1.22A 3erdA-1k1cA:
undetectable		 3erdA-1k1cA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 LEU A  75
ALA A  73
LEU A 106
LEU A 103
LEU A 101
 None
 1.16A 3erdA-1mb9A:
undetectable		 3erdA-1mb9A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mum 2-METHYLISOCITRATE
LYASE

(Escherichia
coli) 		PF13714
(PEP_mutase) 		5 LEU A  83
ALA A  41
LEU A  14
LEU A  20
MET A 156
 None
 1.11A 3erdA-1mumA:
undetectable		 3erdA-1mumA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		5 LEU A 141
ALA A 139
LEU A  73
LEU A  77
LEU A  78
 None
 0.98A 3erdA-1mxfA:
undetectable		 3erdA-1mxfA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 MET A 648
ARG A 660
HIS A 782
LEU A 783
MET A 786
 None
 0.96A 3erdA-1nl3A:
undetectable		 3erdA-1nl3A:
13.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 MET A 343
LEU A 346
ALA A 350
GLU A 353
LEU A 384
LEU A 387
LEU A 391
ARG A 394
MET A 421
HIS A 524
LEU A 525
MET A 528
 EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
None
 0.45A 3erdA-1pcgA:
37.9		 3erdA-1pcgA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 329
LEU A 341
LEU A 408
LEU A 409
LEU A 355
 None
 1.11A 3erdA-1uagA:
undetectable		 3erdA-1uagA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugo BCL2-ASSOCIATED
ATHANOGENE 5

(Mus musculus) 		PF02179
(BAG) 		5 ALA A  79
GLU A  83
LEU A  57
LEU A  53
LEU A  20
 None
 1.13A 3erdA-1ugoA:
undetectable		 3erdA-1ugoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00180
(Iso_dh) 		6 MET A  97
LEU A  98
GLU A 271
LEU A   6
LEU A  69
LEU A  53
 None
 1.50A 3erdA-1vlcA:
undetectable		 3erdA-1vlcA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Mus musculus) 		no annotation 5 LEU A 130
ALA A 161
LEU A 182
LEU A 164
LEU A 142
 None
 1.23A 3erdA-1wwlA:
undetectable		 3erdA-1wwlA:
27.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 324
GLU A 331
LEU A 365
ARG A 372
HIS A 494
 None
 0.56A 3erdA-1xb7A:
28.4		 3erdA-1xb7A:
32.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9u PUTATIVE IRON
BINDING PROTEIN

(Bordetella
pertussis) 		PF13343
(SBP_bac_6) 		5 LEU A  59
ALA A 242
LEU A 257
LEU A 258
LEU A  10
 None
 1.10A 3erdA-1y9uA:
undetectable		 3erdA-1y9uA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.20A 3erdA-1yrwA:
undetectable		 3erdA-1yrwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.18A 3erdA-1z7eA:
undetectable		 3erdA-1z7eA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 LEU A 246
ALA A 250
LEU A 198
LEU A 170
LEU A 173
 None
 0.97A 3erdA-1zklA:
undetectable		 3erdA-1zklA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Saccharomyces
cerevisiae) 		PF00579
(tRNA-synt_1b) 		5 LEU X 198
ALA X 175
GLU X 178
LEU X 206
LEU X 203
 None
 1.21A 3erdA-2dlcX:
undetectable		 3erdA-2dlcX:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE

(Thermus
thermophilus) 		PF01966
(HD)
PF13286
(HD_assoc) 		5 LEU A 327
ALA A 330
LEU A 338
LEU A 337
MET A 362
 None
 1.13A 3erdA-2dqbA:
undetectable		 3erdA-2dqbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		5 ALA A 243
LEU A 278
LEU A 281
LEU A 285
HIS A  97
 None
 0.97A 3erdA-2ef4A:
undetectable		 3erdA-2ef4A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR

(Molluscum
contagiosum
virus) 		PF01335
(DED) 		5 LEU A  99
GLU A 106
LEU A 161
LEU A 169
LEU A 157
 None
 1.09A 3erdA-2f1sA:
undetectable		 3erdA-2f1sA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 268
ALA A 272
GLU A 275
LEU A 309
ARG A 316
HIS A 434
 OHT  A 500 (-4.1A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
 0.47A 3erdA-2gpvA:
26.6		 3erdA-2gpvA:
36.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6g PUTATIVE
METHYLTRANSFERASE

(Salmonella
enterica) 		PF03848
(TehB) 		5 LEU A  23
ALA A  25
LEU A 100
LEU A 131
LEU A  48
 None
MLY  A 167 ( 4.2A)
None
None
None
 1.20A 3erdA-2i6gA:
undetectable		 3erdA-2i6gA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00749
(tRNA-synt_1c) 		5 ALA A  27
LEU A  68
LEU A  65
LEU A  61
HIS A 270
 None
 1.17A 3erdA-2ja2A:
undetectable		 3erdA-2ja2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kr0 PROTEASOMAL
UBIQUITIN RECEPTOR
ADRM1

(Homo sapiens) 		PF04683
(Proteasom_Rpn13)
PF16550
(RPN13_C) 		5 LEU A 347
ALA A 345
LEU A 310
LEU A 340
MET A 356
 None
 1.16A 3erdA-2kr0A:
undetectable		 3erdA-2kr0A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 MET A 291
LEU A 292
ALA A 294
LEU A 406
LEU A 251
 None
 1.14A 3erdA-2nlxA:
undetectable		 3erdA-2nlxA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 MET A 343
LEU A 346
ALA A 350
GLU A 353
LEU A 384
LEU A 387
LEU A 391
ARG A 394
MET A 421
HIS A 524
LEU A 525
MET A 528
 EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
None
 0.56A 3erdA-2ocfA:
36.1		 3erdA-2ocfA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Pseudomonas
savastanoi) 		PF01966
(HD) 		5 ALA A 345
LEU A 249
LEU A 252
HIS A 305
LEU A 306
 None
 1.19A 3erdA-2pgsA:
undetectable		 3erdA-2pgsA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Homo sapiens) 		PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF) 		5 ALA A 600
LEU A 528
LEU A 523
LEU A 500
LEU A 506
 None
 1.19A 3erdA-2pz1A:
undetectable		 3erdA-2pz1A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  32
ALA A  36
LEU A  77
ARG A  80
MET A 108
 1CA  A 247 (-4.0A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
 0.50A 3erdA-2q3yA:
28.1		 3erdA-2q3yA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A  50
ALA A  52
LEU A  65
LEU A  64
LEU A  98
 None
 1.18A 3erdA-2rfaA:
undetectable		 3erdA-2rfaA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 ALA A 346
LEU A 319
LEU A 401
LEU A 327
MET A 330
 None
 0.88A 3erdA-2rkoA:
undetectable		 3erdA-2rkoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		5 ALA A  77
LEU A 211
LEU A 127
MET A 186
LEU A 193
 None
 1.16A 3erdA-2wyxA:
undetectable		 3erdA-2wyxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzm ALDO-KETO REDUCTASE

(Mycolicibacterium
smegmatis) 		PF00248
(Aldo_ket_red) 		5 MET A 261
LEU A 264
LEU A 172
LEU A 203
LEU A 231
 None
 1.18A 3erdA-2wzmA:
undetectable		 3erdA-2wzmA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xva TELLURITE RESISTANCE
PROTEIN TEHB

(Escherichia
coli) 		PF03848
(TehB) 		5 LEU A  23
ALA A  25
LEU A 100
LEU A 131
LEU A  48
 None
 1.19A 3erdA-2xvaA:
undetectable		 3erdA-2xvaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		5 LEU A1009
LEU A1002
LEU A1000
MET A 813
LEU A 936
 None
 1.24A 3erdA-2y3aA:
undetectable		 3erdA-2y3aA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 ALA A   7
LEU A  25
LEU A   5
LEU A   4
LEU A  53
 None
 1.18A 3erdA-2yzmA:
undetectable		 3erdA-2yzmA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		5 LEU A 460
LEU A 452
LEU A 453
LEU A 497
LEU A 770
 None
 1.11A 3erdA-2znsA:
undetectable		 3erdA-2znsA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU B 178
LEU B 245
LEU B 191
HIS B 200
LEU B 225
 None
 1.17A 3erdA-3a79B:
undetectable		 3erdA-3a79B:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b79 TOXIN SECRETION
ATP-BINDING PROTEIN

(Vibrio
parahaemolyticus) 		PF03412
(Peptidase_C39) 		5 LEU A  25
GLU A  46
LEU A  41
LEU A  50
LEU A  36
 None
 1.23A 3erdA-3b79A:
undetectable		 3erdA-3b79A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8p UNCHARACTERIZED
PROTEIN

(Shewanella
oneidensis) 		PF03061
(4HBT) 		5 LEU A  20
LEU A 108
LEU A 105
LEU A 101
LEU A  83
 None
 1.02A 3erdA-3e8pA:
undetectable		 3erdA-3e8pA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY

(Novosphingobium
aromaticivorans) 		PF08445
(FR47) 		6 LEU A  29
ALA A  40
LEU A 223
LEU A  63
ARG A   9
LEU A  54
 None
 1.40A 3erdA-3ec4A:
undetectable		 3erdA-3ec4A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		5 LEU A 366
ALA A 257
LEU A 241
MET A 358
LEU A 267
 None
 1.20A 3erdA-3gzsA:
undetectable		 3erdA-3gzsA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkl MUSCLE, SKELETAL
RECEPTOR TYROSINE
PROTEIN KINASE

(Rattus
norvegicus) 		PF01392
(Fz) 		5 LEU A 437
GLU A 396
LEU A 450
HIS A 377
LEU A 373
 None
 1.19A 3erdA-3hklA:
undetectable		 3erdA-3hklA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky9 PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF)
PF11971
(CAMSAP_CH) 		5 LEU A  33
ALA A  36
LEU A  43
LEU A  42
LEU A  99
 None
 1.20A 3erdA-3ky9A:
undetectable		 3erdA-3ky9A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11

(Homo sapiens) 		PF00621
(RhoGEF) 		6 MET A 796
LEU A 812
GLU A 902
LEU A 889
LEU A 906
LEU A 742
 None
 1.35A 3erdA-3kz1A:
undetectable		 3erdA-3kz1A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2h PUTATIVE SUGAR
PHOSPHATE ISOMERASE

(Acidithiobacillus
ferrooxidans) 		PF07883
(Cupin_2) 		6 GLU A  12
LEU A  36
LEU A   8
LEU A   7
ARG A   4
LEU A  49
 None
None
None
None
None
CXS  A 164 (-4.4A)
 1.48A 3erdA-3l2hA:
undetectable		 3erdA-3l2hA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 5 LEU B 370
ALA B 374
LEU B 405
LEU B 347
LEU B 431
 None
 1.09A 3erdA-3ogkB:
undetectable		 3erdA-3ogkB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p52 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Campylobacter
jejuni) 		PF02540
(NAD_synthase) 		5 LEU A 205
LEU A 216
LEU A 219
LEU A 223
MET A 231
 None
 1.16A 3erdA-3p52A:
undetectable		 3erdA-3p52A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl0 UNCHARACTERIZED
PROTEIN

(Methylibium
petroleiphilum) 		PF10014
(2OG-Fe_Oxy_2) 		5 LEU A 240
ALA A 173
LEU A 126
LEU A 123
MET A  45
 None
 1.00A 3erdA-3pl0A:
undetectable		 3erdA-3pl0A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		5 LEU A 443
LEU A 435
LEU A 436
LEU A 481
LEU A 754
 None
 1.12A 3erdA-3qxmA:
undetectable		 3erdA-3qxmA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY

(Sphaerobacter
thermophilus) 		PF01380
(SIS) 		5 LEU A 166
ALA A 201
LEU A 180
LEU A 177
HIS A 136
 None
 1.04A 3erdA-3shoA:
undetectable		 3erdA-3shoA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t79 KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		5 MET A  71
ALA A  77
LEU A   4
LEU A   7
LEU A  11
 None
 1.17A 3erdA-3t79A:
undetectable		 3erdA-3t79A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u92 GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 LEU A  47
LEU A  39
LEU A  40
LEU A  84
LEU A 236
 None
 1.09A 3erdA-3u92A:
undetectable		 3erdA-3u92A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zee PARTITIONING
DEFECTIVE 3 HOMOLOG

(Rattus
norvegicus) 		PF12053
(DUF3534) 		5 MET A  21
ALA A  69
LEU A  51
LEU A  59
LEU A  26
 None
 1.20A 3erdA-3zeeA:
undetectable		 3erdA-3zeeA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		5 ALA A 379
GLU A 382
LEU A 392
LEU A 389
LEU A 178
 None
 1.17A 3erdA-3zlbA:
undetectable		 3erdA-3zlbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akx EXOU

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		5 ALA B 122
LEU B 109
LEU B 374
LEU B 151
MET B 155
 None
 0.99A 3erdA-4akxB:
undetectable		 3erdA-4akxB:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		5 LEU A1009
LEU A1002
LEU A1000
MET A 813
LEU A 936
 None
 1.17A 3erdA-4bfrA:
undetectable		 3erdA-4bfrA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8y CAS6A

(Thermus
thermophilus) 		PF10040
(CRISPR_Cas6) 		5 ALA A 213
LEU A 148
LEU A 151
LEU A 157
LEU A 167
 None
 1.15A 3erdA-4c8yA:
undetectable		 3erdA-4c8yA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSB

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		5 LEU B 258
ALA B 256
LEU B 248
LEU B 251
LEU B 271
 None
 1.02A 3erdA-4hdsB:
undetectable		 3erdA-4hdsB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijj PUTATIVE C4-TYPE
ZINC FINGER PROTEIN,
DKSA/TRAR FAMILY

(Pseudomonas
aeruginosa) 		PF01258
(zf-dskA_traR) 		5 LEU A 108
LEU A  26
LEU A  27
MET A  15
LEU A   7
 None
 1.15A 3erdA-4ijjA:
undetectable		 3erdA-4ijjA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		5 LEU A 371
GLU A 364
LEU A 358
LEU A 270
LEU A   4
 None
 1.00A 3erdA-4isyA:
undetectable		 3erdA-4isyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 5 ALA D 272
LEU D 309
ARG D 316
HIS D 435
LEU D 436
 None
 1.01A 3erdA-4j5xD:
24.3		 3erdA-4j5xD:
28.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 283
ALA A 287
GLU A 290
LEU A 324
ARG A 331
MET A 358
 None
 0.70A 3erdA-4n1yA:
30.8		 3erdA-4n1yA:
38.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN

([Ruminococcus]
gnavus) 		no annotation 5 MET E 316
ALA E 279
LEU E 283
LEU E 282
LEU E 308
 None
 1.20A 3erdA-4obuE:
undetectable		 3erdA-4obuE:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofx CYSTATHIONINE
BETA-SYNTHASE

(Coxiella
burnetii) 		PF00291
(PALP) 		5 ALA A 276
LEU A  18
LEU A  29
LEU A 290
LEU A 257
 None
 1.21A 3erdA-4ofxA:
undetectable		 3erdA-4ofxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		5 MET A 260
LEU A 263
LEU A 171
LEU A 202
LEU A 230
 None
 1.20A 3erdA-4otkA:
undetectable		 3erdA-4otkA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		5 LEU A 133
ALA A 131
LEU A 157
LEU A 154
LEU A 150
 None
None
None
None
EDO  A 508 (-3.2A)
 1.24A 3erdA-4pzvA:
undetectable		 3erdA-4pzvA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfv ANK-N5C-281

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A  10
ALA A  12
LEU A  25
LEU A  24
LEU A  57
 None
 1.12A 3erdA-4qfvA:
undetectable		 3erdA-4qfvA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r89 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08774
(VRR_NUC) 		5 LEU A 310
ALA A 314
GLU A 323
LEU A 331
LEU A 327
 None
 1.22A 3erdA-4r89A:
undetectable		 3erdA-4r89A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		5 MET B 259
LEU B 262
ALA B 265
LEU B 319
LEU B 441
 None
 1.03A 3erdA-4tx2B:
undetectable		 3erdA-4tx2B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 769
ALA A 773
LEU A 810
LEU A 814
ARG A 817
 CV7  A1987 (-4.1A)
CV7  A1987 (-3.5A)
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
 0.32A 3erdA-4udbA:
27.6		 3erdA-4udbA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 305
LEU A 296
LEU A 286
ARG A 272
LEU A 159
 None
None
None
None
VFV  A 580 (-4.5A)
 1.22A 3erdA-4uhiA:
undetectable		 3erdA-4uhiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.16A 3erdA-4zfhA:
undetectable		 3erdA-4zfhA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Oceanimonas
doudoroffii) 		PF00171
(Aldedh) 		5 MET A 198
ALA A 191
GLU A 190
LEU A  75
LEU A  74
 None
 1.01A 3erdA-4zz7A:
undetectable		 3erdA-4zz7A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnx AMINOPEPTIDASE YPDF

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ALA A 119
LEU A  11
LEU A  16
LEU A  93
HIS A  30
 None
 1.11A 3erdA-5cnxA:
undetectable		 3erdA-5cnxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fej COPM

(Synechocystis
sp. PCC 6803) 		PF03713
(DUF305) 		5 MET A  63
LEU A 128
ALA A 130
HIS A 148
MET A 145
 None
None
None
CU1  A 202 (-2.8A)
CU1  A 202 (-3.3A)
 1.19A 3erdA-5fejA:
undetectable		 3erdA-5fejA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le4 DD_D12_11_D12

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.11A 3erdA-5le4A:
undetectable		 3erdA-5le4A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5leb DDD_D12_06_D12_06_D1
2

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.06A 3erdA-5lebA:
undetectable		 3erdA-5lebA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw2 DARPIN_5M3_D12

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.13A 3erdA-5lw2A:
undetectable		 3erdA-5lw2A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 769
ALA A 773
LEU A 814
ARG A 817
MET A 845
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.8A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
 0.52A 3erdA-5mwpA:
27.4		 3erdA-5mwpA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nh1 GASDERMIN-D

(Homo sapiens) 		PF04598
(Gasdermin) 		5 LEU A 393
LEU A 313
LEU A 312
HIS A 386
LEU A 389
 None
 1.17A 3erdA-5nh1A:
undetectable		 3erdA-5nh1A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 ALA A 797
GLU A 798
LEU A 764
LEU A 803
LEU A 742
 None
 1.17A 3erdA-5o1pA:
undetectable		 3erdA-5o1pA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogx CYTOCHROME P450
REDUCTASE

(Amycolatopsis
methanolica) 		no annotation 5 ALA A 103
LEU A 159
LEU A 120
LEU A 106
LEU A 126
 None
 1.20A 3erdA-5ogxA:
undetectable		 3erdA-5ogxA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 295
LEU A 298
ALA A 302
GLU A 305
LEU A 339
LEU A 343
ARG A 346
HIS A 475
LEU A 476
MET A 479
 EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
None
 0.37A 3erdA-5toaA:
31.1		 3erdA-5toaA:
56.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 MET A 295
LEU A 298
LEU A 354
HIS A 475
LEU A 476
MET A 479
 EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
None
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
None
 1.46A 3erdA-5toaA:
31.1		 3erdA-5toaA:
56.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 MET A  29
LEU A  32
LEU A  77
ARG A  80
MET A 108
 1TA  A 301 ( 2.9A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
 1.19A 3erdA-5ufsA:
27.9		 3erdA-5ufsA:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 MET A  29
LEU A  32
LEU A 201
LEU A  77
ARG A  80
 1TA  A 301 ( 2.9A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.8A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
 1.17A 3erdA-5ufsA:
27.9		 3erdA-5ufsA:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjt REACTION CENTER
MAQUETTE

(synthetic
construct) 		no annotation 5 LEU A  85
LEU A 120
LEU A 121
HIS A 110
LEU A 113
 HEM  A 203 ( 4.8A)
None
None
HEM  A 203 (-3.1A)
None
 1.08A 3erdA-5vjtA:
undetectable		 3erdA-5vjtA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A 665
ALA A 667
LEU A 680
LEU A 679
LEU A 712
 None
 1.18A 3erdA-5vkqA:
undetectable		 3erdA-5vkqA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vws CYTOCHROME P450

(Thermobispora
bispora) 		PF00067
(p450) 		5 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.23A 3erdA-5vwsA:
2.7		 3erdA-5vwsA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A  50
ALA A  52
LEU A  65
LEU A  64
LEU A  98
 LEU  A  50 ( 0.6A)
ALA  A  52 ( 0.0A)
LEU  A  65 ( 0.5A)
LEU  A  64 ( 0.6A)
LEU  A  98 ( 0.6A)
 1.10A 3erdA-5wo6A:
2.1		 3erdA-5wo6A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0w SHARPIN

(Homo sapiens) 		no annotation 5 LEU B 297
ALA B 295
LEU B 283
LEU B 221
LEU B 242
 None
 0.96A 3erdA-5x0wB:
undetectable		 3erdA-5x0wB:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy3 -

(-) 		no annotation 5 LEU A 396
ALA A 398
LEU A 205
LEU A 314
HIS A 389
 None
 1.11A 3erdA-5yy3A:
undetectable		 3erdA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 5 LEU 2   4
LEU 2 157
LEU 2 160
LEU 2 162
LEU 2  49
 None
 1.20A 3erdA-5zvs2:
undetectable		 3erdA-5zvs2:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcb RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 18

(Mus musculus) 		no annotation 5 LEU A 340
LEU A 367
LEU A 368
LEU A 359
HIS A 435
 None
 1.07A 3erdA-6bcbA:
undetectable		 3erdA-6bcbA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5e DD_D12_10_47

(synthetic
construct) 		no annotation 5 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.07A 3erdA-6f5eA:
undetectable		 3erdA-6f5eA:
14.84