SIMILAR PATTERNS OF AMINO ACIDS FOR 3EM6_A_017A200_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		5 ASP A  37
ASP A  11
GLY A  64
LEU A  68
VAL A  82
 None
 1.26A 3em6A-1a2oA:
0.0		 3em6A-1a2oA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awb MYO-INOSITOL
MONOPHOSPHATASE

(Homo sapiens) 		PF00459
(Inositol_P) 		4 GLY A 207
ALA A 208
ASP A 209
VAL A 193
 None
 0.53A 3em6A-1awbA:
0.0		 3em6A-1awbA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		5 GLY A1182
ALA A1183
ASP A1191
GLY A1188
VAL A1176
 FAD  A1363 (-3.4A)
None
None
None
None
 1.23A 3em6A-1c0iA:
0.0		 3em6A-1c0iA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 224
ALA A 223
GLY A 214
LEU A 213
 None
 0.61A 3em6A-1coyA:
undetectable		 3em6A-1coyA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		5 ALA A 404
ASP A 402
GLY A 448
LEU A 449
VAL A 407
 None
 1.13A 3em6A-1dabA:
0.0		 3em6A-1dabA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbv GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 GLY O 112
ALA O 113
ASP O  90
GLY O   4
VAL O 143
 None
 1.31A 3em6A-1dbvO:
undetectable		 3em6A-1dbvO:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 GLY A 321
ALA A 185
ASP A 221
LEU A 318
VAL A 244
 PGD  A 783 (-3.6A)
PGD  A 783 (-3.3A)
PGD  A 783 (-2.9A)
None
None
 1.29A 3em6A-1dmsA:
undetectable		 3em6A-1dmsA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		5 ALA A 218
ASP A 216
ASP A 214
GLY A  52
VAL A 197
 None
 1.43A 3em6A-1e19A:
undetectable		 3em6A-1e19A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		5 GLY A 219
ALA A 218
ASP A 216
ASP A 214
GLY A  52
 None
 1.26A 3em6A-1e19A:
undetectable		 3em6A-1e19A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLY A 106
ALA A 107
ASP A 108
ASP A 138
 None
 0.54A 3em6A-1e43A:
0.0		 3em6A-1e43A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN

(Homo sapiens) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLY A 255
ALA A 254
ASP A 253
GLY A 222
LEU A 225
 None
None
None
FAD  A 599 (-3.1A)
None
 1.21A 3em6A-1efvA:
undetectable		 3em6A-1efvA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei5 D-AMINOPEPTIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase)
PF07930
(DAP_B) 		5 GLY A 454
ALA A 437
ASP A 436
LEU A 440
VAL A 505
 None
 1.40A 3em6A-1ei5A:
undetectable		 3em6A-1ei5A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F

(Bacillus
subtilis) 		PF00072
(Response_reg) 		5 ALA E1234
ASP E1211
ASP E1210
GLY E1236
LEU E1237
 None
MG  E2001 (-3.0A)
MG  E2001 ( 4.0A)
None
None
 1.26A 3em6A-1f51E:
undetectable		 3em6A-1f51E:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fez PHOSPHONOACETALDEHYD
E HYDROLASE

(Bacillus cereus) 		PF13419
(HAD_2) 		4 GLY A 203
ASP A  12
GLY A 207
LEU A 206
 None
MG  A 801 (-3.7A)
None
None
 0.52A 3em6A-1fezA:
undetectable		 3em6A-1fezA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gll GLYCEROL KINASE

(Escherichia
coli) 		no annotation 5 GLY Y 448
ALA Y 447
GLY Y 442
LEU Y 441
VAL Y  20
 None
 1.46A 3em6A-1gllY:
undetectable		 3em6A-1gllY:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		5 GLY A 809
ALA A 810
GLY A 802
LEU A 803
VAL A 535
 None
 1.09A 3em6A-1h7wA:
undetectable		 3em6A-1h7wA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he3 BILIVERDIN IX BETA
REDUCTASE

(Homo sapiens) 		PF13460
(NAD_binding_10) 		4 GLY A  16
GLY A  76
LEU A  75
VAL A 149
 None
NAP  A1206 (-3.5A)
NAP  A1206 (-4.6A)
None
 0.62A 3em6A-1he3A:
undetectable		 3em6A-1he3A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjr HOLLIDAY JUNCTION
RESOLVASE (RUVC)

(Escherichia
coli) 		PF02075
(RuvC) 		5 GLY A  31
ALA A 139
ASP A 141
GLY A   5
LEU A   4
 None
 1.32A 3em6A-1hjrA:
undetectable		 3em6A-1hjrA:
22.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ALA A  28
ASP A  29
ASP A  30
GLY A  48
VAL A  82
 A79  A 800 (-3.2A)
A79  A 800 (-2.7A)
A79  A 800 ( 4.7A)
A79  A 800 (-4.1A)
A79  A 800 (-4.5A)
 0.78A 3em6A-1hvcA:
14.2		 3em6A-1hvcA:
47.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ASP A  25
ALA A  28
ASP A  29
GLY A  48
VAL A  82
 A79  A 800 (-2.7A)
A79  A 800 (-3.1A)
A79  A 800 (-2.8A)
A79  A 800 (-3.6A)
A79  A 800 (-4.5A)
 0.72A 3em6A-1hvcA:
14.2		 3em6A-1hvcA:
47.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		7 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
GLY A  49
VAL A  82
 A79  A 800 (-2.7A)
A79  A 800 (-3.0A)
A79  A 800 (-3.1A)
A79  A 800 (-2.8A)
A79  A 800 ( 4.9A)
A79  A 800 ( 3.7A)
A79  A 800 (-4.5A)
 0.39A 3em6A-1hvcA:
14.2		 3em6A-1hvcA:
47.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		7 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
GLY A  49
VAL A  82
 A79  A 800 (-2.8A)
A79  A 800 (-3.0A)
A79  A 800 (-3.2A)
A79  A 800 (-2.7A)
A79  A 800 ( 4.7A)
A79  A 800 (-3.4A)
A79  A 800 (-4.5A)
 0.34A 3em6A-1hvcA:
14.2		 3em6A-1hvcA:
47.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1

(Homo sapiens) 		PF00415
(RCC1) 		5 GLY B  75
ASP B 128
ASP B 182
GLY B 248
VAL B 177
 None
 1.11A 3em6A-1i2mB:
undetectable		 3em6A-1i2mB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 ALA A 243
ASP A 328
ASP A 242
GLY A 356
VAL A 352
 None
 1.29A 3em6A-1j0hA:
undetectable		 3em6A-1j0hA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		5 ASP A 250
GLY A 251
GLY A 257
LEU A 230
VAL A  51
 None
 1.26A 3em6A-1j33A:
undetectable		 3em6A-1j33A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE

(Thermus
thermophilus) 		PF00764
(Arginosuc_synth) 		5 GLY A 223
ALA A 330
ASP A 327
GLY A  77
VAL A 294
 None
 1.28A 3em6A-1kh2A:
undetectable		 3em6A-1kh2A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt3 HEAT-LABILE
ENTEROTOXIN

(Escherichia
coli) 		PF01375
(Enterotoxin_a) 		5 GLY A 161
ALA A 158
GLY A 102
LEU A 101
VAL A 113
 None
 1.35A 3em6A-1lt3A:
undetectable		 3em6A-1lt3A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		5 GLY A 178
ALA A  58
ASP A 174
GLY A  49
LEU A  47
 None
 1.31A 3em6A-1m33A:
undetectable		 3em6A-1m33A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 ALA A 308
ASP A 307
ASP A 128
LEU A 282
VAL A 132
 None
None
None
None
FAD  A3000 (-4.8A)
 1.43A 3em6A-1m64A:
undetectable		 3em6A-1m64A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ASP A 205
GLY A  24
ASP A 183
GLY A  28
LEU A  30
 None
 1.28A 3em6A-1mdfA:
undetectable		 3em6A-1mdfA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF01380
(SIS) 		5 GLY A 540
ALA A 512
ASP A 511
ASP A 513
LEU A 543
 None
 1.49A 3em6A-1morA:
undetectable		 3em6A-1morA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mp9 TATA-BINDING PROTEIN

(Sulfolobus
acidocaldarius) 		PF00352
(TBP) 		4 GLY A  67
GLY A  49
LEU A  50
VAL A  71
 None
 0.49A 3em6A-1mp9A:
undetectable		 3em6A-1mp9A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n31 L-CYSTEINE/CYSTINE
LYASE C-DES

(Synechocystis
sp. PCC 6714) 		PF00266
(Aminotran_5) 		5 ASP A 197
GLY A 198
ALA A 199
GLY A 233
LEU A 234
 PLP  A2001 (-2.6A)
None
PLP  A2001 (-3.4A)
None
None
 1.27A 3em6A-1n31A:
undetectable		 3em6A-1n31A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n47 ISOLECTIN B4

(Vicia villosa) 		PF00139
(Lectin_legB) 		5 ASP A 141
GLY A 139
ASP A 132
GLY A  86
LEU A  87
 None
None
MN  A 253 ( 2.5A)
None
None
 1.38A 3em6A-1n47A:
undetectable		 3em6A-1n47A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Aeropyrum
pernix) 		PF01791
(DeoC) 		5 GLY A  50
ALA A  46
ASP A  48
GLY A  72
VAL A  55
 None
 1.50A 3em6A-1n7kA:
undetectable		 3em6A-1n7kA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASP A  31
GLY A  30
ALA A  29
GLY A  71
 None
 0.62A 3em6A-1nr0A:
undetectable		 3em6A-1nr0A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny9 TRANSCRIPTIONAL
ACTIVATOR TIPA-S

(Streptomyces
lividans) 		PF07739
(TipAS) 		4 ALA A 243
ASP A 242
GLY A 216
LEU A 215
 None
 0.61A 3em6A-1ny9A:
undetectable		 3em6A-1ny9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLY A  62
ALA A  63
ASP A  96
GLY A  77
VAL A 165
 None
 1.16A 3em6A-1poxA:
undetectable		 3em6A-1poxA:
10.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q9p HIV-1 PROTEASE

(Homo sapiens) 		PF00077
(RVP) 		5 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
 None
 0.45A 3em6A-1q9pA:
10.6		 3em6A-1q9pA:
89.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjp OUTER MEMBRANE
PROTEIN A

(Escherichia
coli) 		PF01389
(OmpA_membrane) 		5 GLY A  36
ALA A  37
ASP A  56
GLY A 165
LEU A 164
 None
C8E  A1176 (-3.7A)
None
None
C8E  A1173 ( 4.3A)
 1.25A 3em6A-1qjpA:
undetectable		 3em6A-1qjpA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmo MANNOSE BINDING
LECTIN, FRIL

(Lablab
purpureus) 		PF00139
(Lectin_legB) 		5 ASP E 158
GLY E 156
ASP E 149
GLY A  87
LEU A  88
 None
None
MN  A 301 ( 2.4A)
None
None
 1.28A 3em6A-1qmoE:
undetectable		 3em6A-1qmoE:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		5 GLY A 370
ASP A 372
GLY A 210
LEU A 209
VAL A 356
 MAP  A 450 (-3.5A)
MAP  A 450 (-3.9A)
None
None
None
 1.00A 3em6A-1qpgA:
undetectable		 3em6A-1qpgA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwl SERINE/THREONINE-PRO
TEIN KINASE PKND

(Mycobacterium
tuberculosis) 		PF01436
(NHL) 		5 ASP A  32
GLY A  35
ASP A 242
LEU A  51
VAL A  80
 None
 1.38A 3em6A-1rwlA:
undetectable		 3em6A-1rwlA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwl SERINE/THREONINE-PRO
TEIN KINASE PKND

(Mycobacterium
tuberculosis) 		PF01436
(NHL) 		5 ASP A 116
GLY A 119
ASP A  75
LEU A 134
VAL A 163
 None
 1.34A 3em6A-1rwlA:
undetectable		 3em6A-1rwlA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5f CHOLERA ENTEROTOXIN,
A CHAIN

(Vibrio cholerae) 		PF01375
(Enterotoxin_a) 		5 GLY A 161
ALA A 158
GLY A 102
LEU A 101
VAL A 113
 None
 1.36A 3em6A-1s5fA:
undetectable		 3em6A-1s5fA:
17.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		6 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
GLY A  49
 None
 0.28A 3em6A-1sivA:
18.5		 3em6A-1sivA:
48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		5 ASP A  25
GLY A  27
ALA A  28
ASP A  29
GLY A  48
 None
 0.79A 3em6A-1sivA:
18.5		 3em6A-1sivA:
48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		5 GLY A  27
ALA A  28
ASP A  29
ASP A  30
VAL A  22
 None
 1.25A 3em6A-1sivA:
18.5		 3em6A-1sivA:
48.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su3 INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 ASP A 231
GLY A 233
ALA A 234
GLY A 271
 None
 0.58A 3em6A-1su3A:
undetectable		 3em6A-1su3A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 ASP A 162
GLY A 158
ALA A 157
ASP A 457
GLY A 462
 None
 1.35A 3em6A-1suvA:
undetectable		 3em6A-1suvA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t35 HYPOTHETICAL PROTEIN
YVDD, PUTATIVE
LYSINE DECARBOXYLASE

(Bacillus
subtilis) 		PF03641
(Lysine_decarbox) 		5 GLY A  47
ALA A  50
ASP A  51
GLY A  26
LEU A  25
 None
 1.37A 3em6A-1t35A:
undetectable		 3em6A-1t35A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t35 HYPOTHETICAL PROTEIN
YVDD, PUTATIVE
LYSINE DECARBOXYLASE

(Bacillus
subtilis) 		PF03641
(Lysine_decarbox) 		5 GLY A  47
ASP A  51
GLY A  26
LEU A  25
VAL A  37
 None
 1.40A 3em6A-1t35A:
undetectable		 3em6A-1t35A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		4 GLY A  95
ALA A  96
LEU A 120
VAL A 116
 None
 0.60A 3em6A-1t8hA:
undetectable		 3em6A-1t8hA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tah LIPASE

(Burkholderia
glumae) 		no annotation 5 ASP B 235
GLY B 297
ALA B 237
ASP B 241
LEU B 248
 None
None
None
CA  B 320 ( 3.1A)
None
 1.49A 3em6A-1tahB:
undetectable		 3em6A-1tahB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		5 GLY A 307
ALA A 308
ASP A 309
LEU A 276
VAL A 269
 None
 1.22A 3em6A-1tjrA:
undetectable		 3em6A-1tjrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlg POLYANDROCARPA
LECTIN

(Polyandrocarpa
misakiensis) 		PF00059
(Lectin_C) 		4 GLY A  56
ALA A  57
ASP A  58
GLY A  72
 None
 0.58A 3em6A-1tlgA:
undetectable		 3em6A-1tlgA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tud ALPHA-SPECTRIN

(Gallus gallus) 		PF00018
(SH3_1) 		5 ASP A  29
GLY A  28
ALA A  11
LEU A   8
VAL A  46
 None
 1.46A 3em6A-1tudA:
undetectable		 3em6A-1tudA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txo PUTATIVE BACTERIAL
ENZYME

(Mycobacterium
tuberculosis) 		PF13672
(PP2C_2) 		5 ALA A  37
ASP A  25
ASP A  38
LEU A  34
VAL A 114
 None
MN  A 700 ( 4.8A)
MN  A 700 ( 2.6A)
None
None
 1.48A 3em6A-1txoA:
undetectable		 3em6A-1txoA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 218
ALA A 219
ASP A 220
LEU A 193
 None
 0.59A 3em6A-1uufA:
undetectable		 3em6A-1uufA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG

(Bacillus
subtilis) 		PF05343
(Peptidase_M42) 		5 GLY A  67
ALA A  66
ASP A 301
LEU A  50
VAL A 206
 None
 1.07A 3em6A-1vheA:
undetectable		 3em6A-1vheA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkf GLYCEROL UPTAKE
OPERON
ANTITERMINATOR-RELAT
ED PROTEIN

(Thermotoga
maritima) 		PF04309
(G3P_antiterm) 		4 GLY A  71
ALA A  72
ASP A  73
VAL A  54
 None
 0.56A 3em6A-1vkfA:
undetectable		 3em6A-1vkfA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrm HYPOTHETICAL PROTEIN
TM1553

(Thermotoga
maritima) 		PF02424
(ApbE) 		5 ASP A 199
GLY A 195
ALA A 299
ASP A 221
LEU A 305
 None
None
None
UNL  A   4 (-2.5A)
None
 1.45A 3em6A-1vrmA:
undetectable		 3em6A-1vrmA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		5 GLY A  44
ALA A  65
GLY A 185
LEU A 182
VAL A 138
 None
 1.34A 3em6A-1wmwA:
undetectable		 3em6A-1wmwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLY A 235
ALA A 236
ASP A 237
VAL A 204
 GLY  A 235 ( 0.0A)
ALA  A 236 ( 0.0A)
ASP  A 237 ( 0.5A)
VAL  A 204 ( 0.6A)
 0.61A 3em6A-1wqaA:
undetectable		 3em6A-1wqaA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		5 GLY A 124
ALA A 139
ASP A 138
LEU A 118
VAL A 146
 None
 1.41A 3em6A-1wzzA:
undetectable		 3em6A-1wzzA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7o ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Streptococcus
pneumoniae) 		PF00574
(CLP_protease) 		4 ASP A  50
ALA A  84
ASP A  85
ASP A  57
 None
 0.55A 3em6A-1y7oA:
undetectable		 3em6A-1y7oA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqd SINAPYL ALCOHOL
DEHYDROGENASE

(Populus
tremuloides) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 323
ASP A 324
GLY A 196
LEU A 195
VAL A  49
 None
None
None
NAP  A 500 (-3.4A)
None
 1.41A 3em6A-1yqdA:
undetectable		 3em6A-1yqdA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 GLY A 539
ALA A 538
ASP A 537
GLY A 532
VAL A 474
 None
 1.35A 3em6A-1yr2A:
undetectable		 3em6A-1yr2A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv9 HYDROLASE, HALOACID
DEHALOGENASE FAMILY

(Enterococcus
faecalis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 GLY A 141
ALA A 142
ASP A 116
LEU A 136
VAL A 120
 None
 1.18A 3em6A-1yv9A:
undetectable		 3em6A-1yv9A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		5 GLY A 261
ALA A 260
ASP A 259
GLY A 254
VAL A 170
 None
 1.37A 3em6A-1ywfA:
undetectable		 3em6A-1ywfA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		5 GLY A 261
ALA A 260
ASP A 259
GLY A 254
VAL A 174
 None
 1.06A 3em6A-1ywfA:
undetectable		 3em6A-1ywfA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		4 GLY C 428
ALA C 427
GLY C 411
VAL C 493
 None
 0.63A 3em6A-2advC:
undetectable		 3em6A-2advC:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az3 NUCLEOSIDE
DIPHOSPHATE KINASE

(Halobacterium
salinarum) 		PF00334
(NDK) 		5 GLY A  93
ALA A  94
ASP A  99
GLY A 110
LEU A 117
 None
 1.35A 3em6A-2az3A:
undetectable		 3em6A-2az3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 GLY A 497
ALA A 496
ASP A 495
GLY A 490
VAL A 430
 None
 1.43A 3em6A-2bklA:
undetectable		 3em6A-2bklA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		5 GLY A 172
ALA A 173
ASP A 174
LEU A 144
VAL A 130
 None
 1.33A 3em6A-2bwgA:
undetectable		 3em6A-2bwgA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwm PSATHYRELLA VELUTINA
LECTIN PVL

(Lacrymaria
velutina) 		PF13517
(VCBS) 		5 ALA A 350
ASP A 351
ASP A 343
GLY A 367
VAL A 294
 None
CA  A1401 (-2.3A)
CA  A1401 (-3.2A)
None
None
 1.48A 3em6A-2bwmA:
undetectable		 3em6A-2bwmA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE

(Luciola
cruciata) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLY A 470
ALA A 469
ASP A 468
VAL A 504
 None
 0.60A 3em6A-2d1qA:
undetectable		 3em6A-2d1qA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 GLY A  62
ALA A  75
ASP A  74
GLY A  80
LEU A  83
 None
 1.38A 3em6A-2e0wA:
undetectable		 3em6A-2e0wA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 GLY A  62
ALA A  75
ASP A  74
GLY A  80
LEU A  83
 None
 1.37A 3em6A-2e0xA:
undetectable		 3em6A-2e0xA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9y CARBAMATE KINASE

(Aeropyrum
pernix) 		PF00696
(AA_kinase) 		5 ALA A 219
ASP A 217
ASP A 215
GLY A  54
VAL A 197
 None
 1.44A 3em6A-2e9yA:
undetectable		 3em6A-2e9yA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		5 ASP A 174
GLY A 176
ASP A 211
GLY A 435
LEU A 436
 GLN  A 501 (-4.5A)
GLN  A 501 (-3.5A)
None
None
None
 1.33A 3em6A-2f2aA:
undetectable		 3em6A-2f2aA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6k METAL-DEPENDENT
HYDROLASE

(Lactobacillus
plantarum) 		PF04909
(Amidohydro_2) 		5 GLY A 120
ALA A 118
ASP A 116
GLY A  80
LEU A  54
 None
 1.33A 3em6A-2f6kA:
undetectable		 3em6A-2f6kA:
18.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		5 ASP A  25
GLY A  27
ALA A  28
ASP A  29
GLY A  54
 LP1  A 201 (-2.3A)
LP1  A 201 (-3.8A)
LP1  A 201 (-3.5A)
LP1  A 201 (-3.6A)
LP1  A 201 (-3.6A)
 0.81A 3em6A-2fmbA:
15.1		 3em6A-2fmbA:
33.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		6 ASP A  25
GLY A  27
ALA A  28
ASP A  29
GLY A  55
VAL A  87
 LP1  A 201 (-2.3A)
LP1  A 201 (-3.8A)
LP1  A 201 (-3.5A)
LP1  A 201 (-3.6A)
LP1  A 201 (-3.4A)
LP1  A 201 ( 4.9A)
 0.31A 3em6A-2fmbA:
15.1		 3em6A-2fmbA:
33.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ger PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1

(Homo sapiens) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 GLY A   7
ALA A   8
ASP A  38
LEU A  15
VAL A  50
 None
 1.42A 3em6A-2gerA:
undetectable		 3em6A-2gerA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn1 THREONINE
DEHYDRATASE
CATABOLIC

(Salmonella
enterica) 		PF00291
(PALP) 		5 GLY A 285
ALA A 284
ASP A 236
GLY A 184
VAL A 261
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
 1.27A 3em6A-2gn1A:
undetectable		 3em6A-2gn1A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus) 		no annotation 5 GLY A 253
ALA A 254
GLY A 245
LEU A 246
VAL A 317
 None
 1.45A 3em6A-2hihA:
undetectable		 3em6A-2hihA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id0 EXORIBONUCLEASE 2

(Escherichia
coli) 		PF00575
(S1)
PF00773
(RNB)
PF08206
(OB_RNB) 		5 GLY A 584
ALA A 585
GLY A 546
LEU A 549
VAL A 631
 None
 1.43A 3em6A-2id0A:
undetectable		 3em6A-2id0A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 ALA A 194
ASP A 195
GLY A 186
LEU A 187
VAL A 178
 None
 1.44A 3em6A-2inyA:
undetectable		 3em6A-2inyA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5t GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01472
(PUA) 		4 GLY A 161
ALA A 162
ASP A 163
VAL A  48
 None
 0.52A 3em6A-2j5tA:
undetectable		 3em6A-2j5tA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		5 GLY A 552
ALA A 551
ASP A 550
ASP A 548
VAL A 518
 None
 1.20A 3em6A-2j6hA:
undetectable		 3em6A-2j6hA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg2 SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
paucimobilis) 		PF00155
(Aminotran_1_2) 		5 GLY A 413
ALA A 412
GLY A 407
LEU A 406
VAL A 374
 None
 0.93A 3em6A-2jg2A:
undetectable		 3em6A-2jg2A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		5 GLY A 169
ALA A 168
ASP A 167
LEU A 172
VAL A  14
 None
 1.32A 3em6A-2kdyA:
undetectable		 3em6A-2kdyA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kho HEAT SHOCK PROTEIN
70

(Escherichia
coli) 		PF00012
(HSP70) 		5 GLY A 374
ALA A 375
GLY A 380
LEU A 382
VAL A 165
 None
 1.33A 3em6A-2khoA:
undetectable		 3em6A-2khoA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mhl OUTER MEMBRANE
PROTEIN W

(Escherichia
coli) 		PF03922
(OmpW) 		4 GLY A 189
ALA A 188
GLY A  12
LEU A  42
 None
 0.60A 3em6A-2mhlA:
undetectable		 3em6A-2mhlA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n1b GTP-BINDING NUCLEAR
PROTEIN RAN

(Homo sapiens) 		PF00071
(Ras) 		5 ASP A  18
GLY A  19
GLY A  74
LEU A  75
VAL A 101
 None
 1.45A 3em6A-2n1bA:
undetectable		 3em6A-2n1bA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n9u RESPONSE REGULATOR

(Erythrobacter
litoralis) 		PF00072
(Response_reg) 		5 GLY A 171
ALA A 170
ASP A 168
LEU A 192
VAL A 216
 None
 1.33A 3em6A-2n9uA:
undetectable		 3em6A-2n9uA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqo GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		5 GLY A  51
ALA A  64
ASP A  63
GLY A  69
LEU A  72
 None
 1.36A 3em6A-2nqoA:
undetectable		 3em6A-2nqoA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaw SPECTRIN ALPHA
CHAIN, BRAIN

(Gallus gallus) 		PF00018
(SH3_1) 		5 ASP A1029
GLY A1028
ALA A1011
LEU A1008
VAL A1046
 None
 1.38A 3em6A-2oawA:
undetectable		 3em6A-2oawA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 GLY A 270
ALA A 288
ASP A 289
GLY A 323
VAL A 300
 None
 1.44A 3em6A-2odlA:
undetectable		 3em6A-2odlA:
13.94