SIMILAR PATTERNS OF AMINO ACIDS FOR 3EM0_B_CHDB500_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbv GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR O 291
SER O 296
VAL O 308
VAL O 239
 None
 0.68A 3em0B-1dbvO:
undetectable		 3em0B-1dbvO:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Giardia
intestinalis) 		PF00156
(Pribosyltran) 		4 THR A  88
VAL A  66
THR A  64
VAL A 121
 None
 0.56A 3em0B-1dqpA:
undetectable		 3em0B-1dqpA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fjj HYPOTHETICAL 17.1
KDA PROTEIN IN
MODC-BIOA INTERGENIC
REGION

(Escherichia
coli) 		PF01161
(PBP) 		4 THR A 119
VAL A  47
THR A  49
VAL A  65
 None
 0.45A 3em0B-1fjjA:
undetectable		 3em0B-1fjjA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyu ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT

(Mus musculus) 		PF02883
(Alpha_adaptinC2) 		5 THR A 720
GLU A 722
VAL A 732
THR A 734
VAL A 781
 None
 0.74A 3em0B-1gyuA:
2.2		 3em0B-1gyuA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyv ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT

(Mus musculus) 		PF02883
(Alpha_adaptinC2) 		4 THR A 720
VAL A 732
THR A 734
VAL A 781
 None
 0.59A 3em0B-1gyvA:
2.2		 3em0B-1gyvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 THR A 920
VAL A 944
THR A 946
VAL A 955
 None
 0.41A 3em0B-1hn0A:
3.3		 3em0B-1hn0A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu1 GAMMA1-ADAPTIN

(Homo sapiens) 		PF02883
(Alpha_adaptinC2) 		5 THR A 720
GLU A 722
VAL A 732
THR A 734
VAL A 781
 None
 0.75A 3em0B-1iu1A:
2.1		 3em0B-1iu1A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		4 GLU A 107
VAL A 114
THR A 116
VAL A 125
 None
 0.35A 3em0B-1jjxA:
14.9		 3em0B-1jjxA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lsh LIPOVITELLIN (LV-1N,
LV-1C)

(Ichthyomyzon
unicuspis) 		PF01347
(Vitellogenin_N)
PF09172
(DUF1943) 		4 THR A 159
VAL A 174
THR A 176
VAL A 213
 None
 0.32A 3em0B-1lshA:
3.3		 3em0B-1lshA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdc INSECT FATTY ACID
BINDING PROTEIN

(Manduca sexta) 		PF00061
(Lipocalin) 		4 THR A 117
VAL A 100
THR A 102
VAL A  93
 None
 0.45A 3em0B-1mdcA:
14.0		 3em0B-1mdcA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mp9 TATA-BINDING PROTEIN

(Sulfolobus
acidocaldarius) 		PF00352
(TBP) 		4 THR A  60
VAL A  70
THR A  72
VAL A  19
 None
 0.35A 3em0B-1mp9A:
undetectable		 3em0B-1mp9A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 THR A  39
VAL A  48
THR A  50
VAL A  68
 None
 0.50A 3em0B-1mz5A:
1.3		 3em0B-1mz5A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvp TATA BOX BINDING
PROTEIN

(Homo sapiens) 		PF00352
(TBP) 		4 THR A 210
VAL A 220
THR A 222
VAL A 169
 None
 0.50A 3em0B-1nvpA:
undetectable		 3em0B-1nvpA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p32 MITOCHONDRIAL MATRIX
PROTEIN, SF2P32

(Homo sapiens) 		PF02330
(MAM33) 		4 LYS A 119
THR A 130
VAL A 169
VAL A 183
 None
 0.55A 3em0B-1p32A:
2.6		 3em0B-1p32A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4p OUTER SURFACE
PROTEIN B

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		5 LYS A 159
THR A 167
GLU A 169
VAL A 183
THR A 185
 None
 0.71A 3em0B-1p4pA:
undetectable		 3em0B-1p4pA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pwe L-SERINE DEHYDRATASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 THR A 105
GLU A 107
VAL A  86
VAL A  61
 None
 0.62A 3em0B-1pweA:
undetectable		 3em0B-1pweA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sml PROTEIN
(PENICILLINASE)

(Stenotrophomonas
maltophilia) 		PF00753
(Lactamase_B) 		4 THR A 168
VAL A 151
THR A 153
VAL A 144
 None
 0.56A 3em0B-1smlA:
undetectable		 3em0B-1smlA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tba TRANSCRIPTION
INITIATION FACTOR
TFIID

(Saccharomyces
cerevisiae) 		PF00352
(TBP) 		4 THR B 112
VAL B 122
THR B 124
VAL B  71
 None
 0.34A 3em0B-1tbaB:
undetectable		 3em0B-1tbaB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uis RED FLUORESCENT
PROTEIN FP611

(Entacmaea
quadricolor) 		PF01353
(GFP) 		4 THR A 122
VAL A 101
THR A 103
VAL A  93
 None
 0.35A 3em0B-1uisA:
undetectable		 3em0B-1uisA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtl TATA BINDING PROTEIN
(TBP)

(Arabidopsis
thaliana) 		PF00352
(TBP) 		4 THR E  70
VAL E  80
THR E  82
VAL E  29
 None
 0.32A 3em0B-1vtlE:
undetectable		 3em0B-1vtlE:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9f FK506-BINDING
PROTEIN 8 VARIANT

(Homo sapiens) 		PF00254
(FKBP_C) 		4 THR A 120
VAL A  39
THR A  41
VAL A  61
 None
 0.49A 3em0B-2d9fA:
undetectable		 3em0B-2d9fA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dav MYOSIN-BINDING
PROTEIN C, SLOW-TYPE

(Homo sapiens) 		PF07679
(I-set) 		5 THR A  65
GLU A  67
SER A  70
VAL A  72
THR A  74
 None
 1.09A 3em0B-2davA:
undetectable		 3em0B-2davA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkj OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		4 THR A  98
GLU A 100
THR A  89
VAL A  75
 None
 0.64A 3em0B-2fkjA:
3.2		 3em0B-2fkjA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi8 SULFATASE-MODIFYING
FACTOR 1

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		5 LYS X 138
THR X 134
GLU X 135
VAL X 131
VAL X 281
 None
NAG  X   1 (-4.3A)
None
None
None
 1.44A 3em0B-2hi8X:
undetectable		 3em0B-2hi8X:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j63 AP-ENDONUCLEASE

(Leishmania
major) 		PF03372
(Exo_endo_phos) 		4 THR A 221
VAL A 252
THR A 254
VAL A 273
 None
 0.41A 3em0B-2j63A:
undetectable		 3em0B-2j63A:
14.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lba BABP PROTEIN

(Gallus gallus) 		PF14651
(Lipocalin_7) 		4 LYS A  89
THR A 100
GLU A 102
VAL A 109
 None
 0.59A 3em0B-2lbaA:
19.7		 3em0B-2lbaA:
60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A   7
GLU A   9
THR A  58
VAL A  64
 None
 0.61A 3em0B-2nqlA:
undetectable		 3em0B-2nqlA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyk M157

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 THR A 219
GLU A 221
THR A 230
VAL A 195
 None
 0.56A 3em0B-2nykA:
undetectable		 3em0B-2nykA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyp BETA-LACTAMASE II

(Bacillus cereus) 		PF00753
(Lactamase_B) 		4 THR A 131
VAL A 140
THR A 142
VAL A 156
 None
 0.47A 3em0B-2nypA:
undetectable		 3em0B-2nypA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		4 THR A 358
VAL A 367
THR A 369
VAL A 328
 None
 0.53A 3em0B-2o0xA:
undetectable		 3em0B-2o0xA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3c APEX NUCLEASE 1

(Danio rerio) 		PF03372
(Exo_endo_phos) 		4 THR A 136
VAL A 150
THR A 152
VAL A 161
 None
 0.44A 3em0B-2o3cA:
undetectable		 3em0B-2o3cA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o96 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 7

(Homo sapiens) 		PF01398
(JAB) 		4 THR A 159
GLU A 161
VAL A  10
VAL A  47
 None
 0.56A 3em0B-2o96A:
undetectable		 3em0B-2o96A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ol8 OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		4 THR O  98
GLU O 100
THR O  89
VAL O  75
 None
 0.64A 3em0B-2ol8O:
3.4		 3em0B-2ol8O:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p67 LAO/AO TRANSPORT
SYSTEM KINASE

(Escherichia
coli) 		PF03308
(ArgK) 		4 THR A  60
VAL A 152
THR A 154
VAL A  90
 None
 0.51A 3em0B-2p67A:
undetectable		 3em0B-2p67A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg3 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC

(Pectobacterium
atrosepticum) 		PF06508
(QueC) 		4 THR A 158
VAL A 119
THR A 121
VAL A   7
 None
 0.62A 3em0B-2pg3A:
undetectable		 3em0B-2pg3A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 THR A 536
VAL A 470
THR A 468
VAL A 442
 None
 0.56A 3em0B-2q27A:
undetectable		 3em0B-2q27A:
12.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		4 LYS A  88
GLU A 101
VAL A 108
THR A 110
 None
 0.40A 3em0B-2qo4A:
20.2		 3em0B-2qo4A:
45.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 THR A 386
VAL A 291
THR A 289
VAL A 312
 None
 0.60A 3em0B-2v6oA:
undetectable		 3em0B-2v6oA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgl GFP-LIKE FLUORESCENT
CHROMOPROTEIN
DSFP483

(Discosoma
striata) 		PF01353
(GFP) 		4 THR A  92
GLU A  94
VAL A 180
VAL A 156
 None
 0.56A 3em0B-3cglA:
undetectable		 3em0B-3cglA:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		6 LYS A  89
GLU A 102
SER A 104
VAL A 109
THR A 111
VAL A 124
 None
 0.70A 3em0B-3elzA:
23.6		 3em0B-3elzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		6 LYS A  89
THR A 100
GLU A 102
VAL A 109
THR A 111
VAL A 124
 None
 0.48A 3em0B-3elzA:
23.6		 3em0B-3elzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 THR A 246
GLU A 248
VAL A 228
THR A 226
VAL A 205
 None
 1.11A 3em0B-3g06A:
undetectable		 3em0B-3g06A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzr UNCHARACTERIZED
PROTEIN WITH A
NTF2-LIKE FOLD

(Caulobacter
vibrioides) 		PF14534
(DUF4440) 		4 THR A 100
GLU A 102
VAL A 114
THR A 116
 None
 0.65A 3em0B-3gzrA:
2.6		 3em0B-3gzrA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io1 AMINOBENZOYL-GLUTAMA
TE UTILIZATION
PROTEIN

(Klebsiella
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 THR A 229
VAL A 298
THR A 300
VAL A 276
 None
 0.55A 3em0B-3io1A:
undetectable		 3em0B-3io1A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9q TUBE

(Pseudomonas
aeruginosa) 		PF04985
(Phage_tube) 		4 GLU S 135
VAL S 100
THR S 102
VAL S  84
 None
 0.61A 3em0B-3j9qS:
undetectable		 3em0B-3j9qS:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjg BETA-TYPE
PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF00047
(ig)
PF13927
(Ig_3) 		4 GLU X  72
VAL X  84
THR X  86
VAL X  51
 None
 0.60A 3em0B-3mjgX:
undetectable		 3em0B-3mjgX:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otl PUTATIVE
UNCHARACTERIZED
PROTEIN

(Rhizobium
leguminosarum) 		PF08327
(AHSA1) 		4 THR A 105
VAL A 118
THR A 120
VAL A  12
 None
 0.27A 3em0B-3otlA:
3.3		 3em0B-3otlA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phs CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		no annotation 4 THR A 109
VAL A  36
THR A  34
VAL A 144
 None
 0.54A 3em0B-3phsA:
undetectable		 3em0B-3phsA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3put HYPOTHETICAL
CONSERVED PROTEIN

(Rhizobium etli) 		PF08327
(AHSA1) 		4 THR A 105
VAL A 118
THR A 120
VAL A  12
 None
 0.24A 3em0B-3putA:
3.2		 3em0B-3putA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc2 GLYCOSYL HYDROLASE

(Bacteroides
ovatus) 		PF04041
(Glyco_hydro_130) 		4 THR A 182
VAL A 172
THR A 174
VAL A 157
 None
 0.60A 3em0B-3qc2A:
undetectable		 3em0B-3qc2A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qs1 PLASMEPSIN-1

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 THR A 166
VAL A 150
THR A 152
VAL A 312
 None
 0.67A 3em0B-3qs1A:
undetectable		 3em0B-3qs1A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Synechocystis
sp. PCC 6803) 		PF03320
(FBPase_glpX) 		4 THR A 332
VAL A 313
THR A 315
VAL A 306
 None
 0.43A 3em0B-3rplA:
2.3		 3em0B-3rplA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpx COMPLEMENT COMPONENT
1 Q
SUBCOMPONENT-BINDING
PROTEIN

(Homo sapiens) 		PF02330
(MAM33) 		4 LYS A 119
THR A 130
VAL A 169
VAL A 183
 None
 0.57A 3em0B-3rpxA:
undetectable		 3em0B-3rpxA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3taw HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Parabacteroides
distasonis) 		PF04041
(Glyco_hydro_130) 		4 THR A 187
VAL A 177
THR A 179
VAL A 162
 None
 0.56A 3em0B-3tawA:
undetectable		 3em0B-3tawA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ult ICE
RECRYSTALLIZATION
INHIBITION
PROTEIN-LIKE PROTEIN

(Lolium perenne) 		no annotation 4 THR A  29
VAL A  46
THR A  44
VAL A  59
 None
EDO  A 134 (-4.2A)
EOH  A 139 ( 4.7A)
None
 0.61A 3em0B-3ultA:
undetectable		 3em0B-3ultA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un1 PROBABLE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 THR A  10
VAL A  32
THR A  34
VAL A  49
 None
 0.54A 3em0B-3un1A:
undetectable		 3em0B-3un1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10672
(Methyltrans_SAM) 		4 THR A 327
VAL A 291
THR A 289
VAL A 218
 None
 0.60A 3em0B-3vseA:
undetectable		 3em0B-3vseA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		4 THR A 163
VAL A 151
THR A 153
VAL A 142
 None
 0.30A 3em0B-3welA:
2.5		 3em0B-3welA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0a TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1,
LINKER,
TATA-BOX-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00352
(TBP) 		5 LYS A 318
SER A  29
VAL A 171
THR A 173
VAL A 222
 None
None
None
GOL  A1070 ( 4.1A)
None
 1.37A 3em0B-4b0aA:
undetectable		 3em0B-4b0aA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0a TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1,
LINKER,
TATA-BOX-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00352
(TBP) 		4 THR A 212
VAL A 222
THR A 224
VAL A 171
 GOL  A1242 (-3.8A)
None
GOL  A1243 (-3.0A)
None
 0.32A 3em0B-4b0aA:
undetectable		 3em0B-4b0aA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 THR A 151
VAL A 158
THR A 160
VAL A 296
 None
 0.55A 3em0B-4fnqA:
2.7		 3em0B-4fnqA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghb HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF15283
(DUF4595) 		4 THR A 115
VAL A 124
THR A 126
VAL A 132
 None
 0.46A 3em0B-4ghbA:
undetectable		 3em0B-4ghbA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghb HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF15283
(DUF4595) 		4 THR A 147
VAL A 132
THR A 134
VAL A 124
 None
 0.37A 3em0B-4ghbA:
undetectable		 3em0B-4ghbA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqt HEAT SHOCK PROTEIN
90

(Caenorhabditis
elegans) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LYS A 173
THR A  78
THR A  69
VAL A 209
 None
 0.46A 3em0B-4gqtA:
undetectable		 3em0B-4gqtA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhu OR280

(synthetic
construct) 		no annotation 4 THR A  33
VAL A  46
THR A  48
VAL A   3
 None
 0.49A 3em0B-4hhuA:
undetectable		 3em0B-4hhuA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhu OR280

(synthetic
construct) 		no annotation 4 THR A 114
VAL A 127
THR A 129
VAL A  84
 None
 0.61A 3em0B-4hhuA:
undetectable		 3em0B-4hhuA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3c BILIRUBIN-INDUCIBLE
FLUORESCENT PROTEIN
UNAG

(Anguilla
japonica) 		PF00061
(Lipocalin) 		5 LYS A  96
GLU A 113
VAL A 120
THR A 122
VAL A 131
 None
 0.66A 3em0B-4i3cA:
15.8		 3em0B-4i3cA:
29.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikc PHOSPHOTIDYLINOSITOL
PHOSPHATASE PTPRQ

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 GLU A2829
VAL A2809
THR A2811
VAL A2802
 None
 0.43A 3em0B-4ikcA:
undetectable		 3em0B-4ikcA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j57 THIOREDOXIN
REDUCTASE 2

(Plasmodium
falciparum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 THR A 309
VAL A 227
THR A 225
VAL A 248
 None
 0.64A 3em0B-4j57A:
undetectable		 3em0B-4j57A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC

(Rattus
norvegicus) 		no annotation 4 THR E 286
VAL E 195
THR E 193
VAL E 216
 None
 0.63A 3em0B-4kprE:
undetectable		 3em0B-4kprE:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0n REPLICASE
POLYPROTEIN 1AB

(Equine
arteritis virus) 		PF01443
(Viral_helicase1) 		4 THR A 180
VAL A 239
THR A 237
VAL A 259
 None
 0.67A 3em0B-4n0nA:
undetectable		 3em0B-4n0nA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 THR A  16
GLU A  18
VAL A  31
VAL A  38
 None
 0.56A 3em0B-4nbqA:
undetectable		 3em0B-4nbqA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oir DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Thermus
thermophilus) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 LYS A 194
GLU A  26
VAL A  10
THR A  12
 None
 0.64A 3em0B-4oirA:
undetectable		 3em0B-4oirA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onz PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
ovatus) 		PF04041
(Glyco_hydro_130) 		4 THR A 180
VAL A 170
THR A 172
VAL A 155
 None
 0.64A 3em0B-4onzA:
undetectable		 3em0B-4onzA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN

(Fusobacterium
nucleatum) 		PF03480
(DctP) 		4 THR A  64
VAL A  29
THR A  31
VAL A  87
 IMD  A 406 ( 3.6A)
None
None
None
 0.62A 3em0B-4pfbA:
undetectable		 3em0B-4pfbA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3o MGS-MT1

(unidentified) 		PF07859
(Abhydrolase_3) 		4 THR A  93
GLU A  95
THR A 108
VAL A 151
 None
 0.53A 3em0B-4q3oA:
undetectable		 3em0B-4q3oA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		5 THR A 320
GLU A 316
VAL A 315
THR A 319
VAL A 188
 None
 1.40A 3em0B-4r1zA:
undetectable		 3em0B-4r1zA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		5 LYS B  89
THR B  74
GLU B  76
THR B  44
VAL B  50
 None
 0.87A 3em0B-4rs1B:
undetectable		 3em0B-4rs1B:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs ECU04_1440 PROTEIN

(Encephalitozoon
cuniculi) 		PF00352
(TBP) 		4 THR D  70
VAL D  80
THR D  82
VAL D  29
 None
 0.53A 3em0B-4wzsD:
2.5		 3em0B-4wzsD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn3 CUCUMISIN

(Cucumis melo) 		PF05922
(Inhibitor_I9) 		4 THR B  51
SER B  47
VAL B  61
VAL B  15
 None
 0.59A 3em0B-4yn3B:
undetectable		 3em0B-4yn3B:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		4 LYS A 691
GLU A 676
VAL A 631
THR A 633
 None
 0.64A 3em0B-4zgvA:
2.0		 3em0B-4zgvA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		4 THR A   5
VAL A  10
THR A  12
VAL A  48
 None
 0.46A 3em0B-5dtpA:
undetectable		 3em0B-5dtpA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		4 THR A 217
GLU A 219
VAL A 185
VAL A 160
 None
 0.66A 3em0B-5dtrA:
undetectable		 3em0B-5dtrA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		4 LYS A 303
GLU A 312
VAL A 272
VAL A 260
 None
AMP  A1002 (-3.5A)
AMP  A1002 (-4.6A)
AMP  A1002 (-4.2A)
 0.61A 3em0B-5dztA:
undetectable		 3em0B-5dztA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		4 THR A 412
GLU A 414
VAL A 370
THR A 372
 None
 0.59A 3em0B-5fbzA:
undetectable		 3em0B-5fbzA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fz5 TATA-BOX-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00352
(TBP) 		4 THR O 112
VAL O 122
THR O 124
VAL O  71
 None
 0.32A 3em0B-5fz5O:
undetectable		 3em0B-5fz5O:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikl GERANYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		4 THR B 143
VAL B 183
THR B 181
VAL B 201
 None
 0.66A 3em0B-5iklB:
undetectable		 3em0B-5iklB:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		4 THR A 411
VAL A 371
THR A 373
VAL A 338
 None
 0.58A 3em0B-5infA:
undetectable		 3em0B-5infA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy7 TATA-BOX-BINDING
PROTEIN

(Homo sapiens) 		PF00352
(TBP) 		4 THR P 210
VAL P 220
THR P 222
VAL P 169
 None
 0.58A 3em0B-5iy7P:
undetectable		 3em0B-5iy7P:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7u MAJOR CAPSID PROTEIN

(Faustovirus) 		PF04451
(Capsid_NCLDV) 		4 THR A 344
GLU A 346
THR A 153
VAL A 138
 None
 0.64A 3em0B-5j7uA:
4.1		 3em0B-5j7uA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 LYS A 336
THR A 275
GLU A 277
THR A 236
VAL A 246
 None
 0.72A 3em0B-5jouA:
undetectable		 3em0B-5jouA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kia L-THREONINE
3-DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 170
VAL A 192
THR A 194
VAL A 213
 None
 0.57A 3em0B-5kiaA:
undetectable		 3em0B-5kiaA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgx PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8

(Homo sapiens) 		PF00254
(FKBP_C)
PF07719
(TPR_2) 		4 THR E 202
VAL E 122
THR E 124
VAL E 144
 None
 0.61A 3em0B-5mgxE:
undetectable		 3em0B-5mgxE:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		4 THR A 729
VAL A 752
THR A 750
VAL A 779
 None
 0.56A 3em0B-5n8pA:
undetectable		 3em0B-5n8pA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		4 THR A 729
VAL A 752
THR A 750
VAL A 779
 None
 0.54A 3em0B-5n97A:
undetectable		 3em0B-5n97A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njo PUTATIVE CUPIN_2
DOMAIN-CONTAINING
ISOMERASE

(Streptomyces
coeruleorubidus) 		no annotation 4 THR A  54
VAL A  96
THR A  98
VAL A  33
 None
 0.35A 3em0B-5njoA:
undetectable		 3em0B-5njoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xll SERINE/THREONINE-PRO
TEIN KINASE PKNI

(Mycobacterium
tuberculosis) 		no annotation 4 THR A 504
VAL A 522
THR A 524
VAL A 536
 None
 0.24A 3em0B-5xllA:
3.9		 3em0B-5xllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xlm SERINE/THREONINE-PRO
TEIN KINASE PKNI

(Mycobacterium
tuberculosis) 		no annotation 4 THR A 504
VAL A 522
THR A 524
VAL A 536
 None
 0.42A 3em0B-5xlmA:
5.9		 3em0B-5xlmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3p AMY13K

([Eubacterium]
rectale) 		no annotation 4 THR A 306
VAL A 332
THR A 334
VAL A 280
 None
FMT  A 421 (-4.1A)
EDO  A 411 ( 3.8A)
EDO  A 411 (-4.1A)
 0.41A 3em0B-6b3pA:
undetectable		 3em0B-6b3pA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE DELTA
CHAIN, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 THR d 222
VAL d 179
THR d 181
VAL d 212
 None
 0.53A 3em0B-6fkhd:
undetectable		 3em0B-6fkhd:
undetectable