SIMILAR PATTERNS OF AMINO ACIDS FOR 3EM0_B_CHDB151_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b43 PROTEIN (FEN-1)

(Pyrococcus
furiosus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 ILE A 252
ILE A 244
GLY A 239
PRO A   3
LEU A 260
 None
 1.14A 3em0B-1b43A:
undetectable		 3em0B-1b43A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cia CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		5 ILE A  39
ILE A 207
VAL A 203
PRO A 171
LEU A 213
 None
 1.10A 3em0B-1ciaA:
0.0		 3em0B-1ciaA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csy SYK PROTEIN TYROSINE
KINASE

(Homo sapiens) 		PF00017
(SH2) 		5 TYR A  91
ILE A  41
ILE A  65
GLY A  78
LEU A 102
 None
 1.00A 3em0B-1csyA:
0.8		 3em0B-1csyA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxx DYSTROPHIN

(Homo sapiens) 		PF00307
(CH) 		5 ILE A  94
ILE A  99
GLY A  47
LEU A  53
LEU A  84
 None
 1.15A 3em0B-1dxxA:
undetectable		 3em0B-1dxxA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I

(Homo sapiens) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ILE A 461
ILE A 464
VAL A 374
LYS A 375
LEU A 389
 None
 1.18A 3em0B-1jcnA:
undetectable		 3em0B-1jcnA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 ILE B 442
ILE B 495
VAL B 493
GLY B 437
LEU B 386
 None
 1.01A 3em0B-1m2vB:
0.0		 3em0B-1m2vB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		5 ILE A 264
VAL A 205
GLY A 209
PHE A 212
LEU A 275
 None
 1.05A 3em0B-1pujA:
undetectable		 3em0B-1pujA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qag UTROPHIN ACTIN
BINDING REGION

(Homo sapiens) 		PF00307
(CH) 		5 ILE A 110
ILE A 115
GLY A  63
LEU A  69
LEU A 100
 None
 1.06A 3em0B-1qagA:
undetectable		 3em0B-1qagA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)

(Treponema
pallidum) 		PF01297
(ZnuA) 		5 ILE A 272
ILE A 245
VAL A 196
LYS A 214
GLY A 215
 None
 1.08A 3em0B-1toaA:
0.0		 3em0B-1toaA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 225
ILE A 288
VAL A 270
GLY A 290
LEU A 324
 None
 1.06A 3em0B-1xmbA:
0.0		 3em0B-1xmbA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycl S-RIBOSYLHOMOCYSTEIN
ASE

(Bacillus
subtilis) 		PF02664
(LuxS) 		5 ILE A  79
ILE A  38
VAL A  19
LEU A 145
LEU A  56
 KRI  A 401 (-4.9A)
None
None
None
None
 1.11A 3em0B-1yclA:
0.5		 3em0B-1yclA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeh FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M) 		5 ILE A  56
ILE A  67
VAL A  64
GLY A 103
ARG A  35
 None
 1.17A 3em0B-2aehA:
1.5		 3em0B-2aehA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dua PHOSPHONOPYRUVATE
HYDROLASE

(Variovorax sp.
Pal2) 		PF13714
(PEP_mutase) 		5 ILE A 153
ILE A  79
GLY A  37
LEU A  16
LEU A  11
 None
 1.11A 3em0B-2duaA:
undetectable		 3em0B-2duaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 ILE A 221
ILE A 355
LYS A 339
GLY A 338
LEU A 397
 None
 0.82A 3em0B-2eo5A:
undetectable		 3em0B-2eo5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COA
CARBOXYLASE,
CARBOXYLTRANSFERASE
ALPHA CHAIN

(Escherichia
coli) 		PF03255
(ACCA) 		5 ILE A 115
ILE A 158
VAL A 196
LYS A 216
LEU A 220
 None
 1.09A 3em0B-2f9yA:
undetectable		 3em0B-2f9yA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft3 BIGLYCAN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 TYR A 216
ILE A 187
PHE A 169
LEU A 177
LEU A 219
 None
 1.15A 3em0B-2ft3A:
undetectable		 3em0B-2ft3A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggj N-ACYLAMINO ACID
RACEMASE

(Deinococcus
radiodurans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TYR A 200
ILE A 238
ILE A 219
VAL A 194
PRO A 179
 None
 1.10A 3em0B-2ggjA:
undetectable		 3em0B-2ggjA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijx DNA POLYMERASE
SLIDING CLAMP A

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 TYR A 196
ILE A 164
GLY A 219
PHE A 128
LEU A 201
 None
 1.15A 3em0B-2ijxA:
1.1		 3em0B-2ijxA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lr4 SPBC2
PROPHAGE-DERIVED
UNCHARACTERIZED
PROTEIN YOLA

(Bacillus
subtilis) 		PF16219
(DUF4879) 		5 ILE A  12
ILE A 106
LYS A  61
GLY A  60
LEU A  67
 None
 1.03A 3em0B-2lr4A:
undetectable		 3em0B-2lr4A:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2g DIENELACTONE
HYDROLASE

(Trichormus
variabilis) 		PF01738
(DLH) 		5 ILE A 193
ILE A 165
GLY A 119
LEU A 206
ARG A  51
 None
None
None
None
SO4  A 223 (-3.8A)
 1.06A 3em0B-2o2gA:
undetectable		 3em0B-2o2gA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwz MALATE DEHYDROGENASE

(Escherichia
coli) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A  75
GLY A 145
PHE A 144
LEU A 238
LEU A  16
 None
 1.08A 3em0B-2pwzA:
undetectable		 3em0B-2pwzA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		6 CYH A 227
ILE A 225
ILE A 349
PHE A 176
LEU A 180
LEU A  46
 None
 1.40A 3em0B-2pyxA:
undetectable		 3em0B-2pyxA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vid SERINE PROTEASE SPLB

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 ILE A  34
VAL A  19
GLY A  17
LEU A 168
PRO A 160
 None
 1.18A 3em0B-2vidA:
undetectable		 3em0B-2vidA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa5 FILAMIN-B

(Homo sapiens) 		PF00307
(CH) 		5 ILE A  97
ILE A 102
GLY A  47
LEU A  53
LEU A  87
 None
 0.96A 3em0B-2wa5A:
undetectable		 3em0B-2wa5A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z37 CHITINASE

(Brassica juncea) 		PF00182
(Glyco_hydro_19) 		5 TYR A 337
ILE A 343
ILE A 344
GLY A 207
PHE A 206
 None
 1.02A 3em0B-2z37A:
undetectable		 3em0B-2z37A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zd2 ATP12 ATPASE

(Paracoccus
denitrificans) 		PF07542
(ATP12) 		5 ILE A1190
VAL A1185
GLY A1182
LEU A1101
PRO A1176
 None
 1.07A 3em0B-2zd2A:
undetectable		 3em0B-2zd2A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwn L-TRYPTOPHAN
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF04864
(Alliinase_C) 		5 ILE A  77
VAL A  83
GLY A  85
PRO A 197
LEU A 230
 None
 1.13A 3em0B-3bwnA:
undetectable		 3em0B-3bwnA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 CYH A3129
ILE A3093
ILE A3141
LEU A3215
LEU A3126
 None
 1.18A 3em0B-3cmvA:
undetectable		 3em0B-3cmvA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ILE B 292
ILE B 284
VAL B 252
LEU B   5
LEU B 272
 None
None
MPD  B 501 ( 4.7A)
None
None
 1.18A 3em0B-3dm9B:
undetectable		 3em0B-3dm9B:
18.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		9 TYR A  14
CYH A  18
ILE A  21
ILE A  23
VAL A  27
LYS A  30
GLY A  31
PHE A  34
LEU A 123
 CHD  A 151 (-4.9A)
CHD  A 151 ( 4.2A)
CHD  A 153 ( 4.1A)
CHD  A 200 ( 4.7A)
CHD  A 152 ( 4.3A)
CHD  A 152 ( 4.1A)
CHD  A 151 (-3.6A)
CHD  A 151 ( 4.6A)
CHD  A 151 (-4.2A)
 0.70A 3em0B-3elzA:
23.6		 3em0B-3elzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		6 TYR A  14
GLY A  31
PHE A  34
LEU A  36
LEU A 123
ARG A 125
 CHD  A 151 (-4.9A)
CHD  A 151 (-3.6A)
CHD  A 151 ( 4.6A)
None
CHD  A 151 (-4.2A)
CHD  A 151 (-4.1A)
 1.35A 3em0B-3elzA:
23.6		 3em0B-3elzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		6 TYR A  14
PHE A  34
LEU A  36
PRO A  54
LEU A 123
ARG A 125
 CHD  A 151 (-4.9A)
CHD  A 151 ( 4.6A)
None
None
CHD  A 151 (-4.2A)
CHD  A 151 (-4.1A)
 1.44A 3em0B-3elzA:
23.6		 3em0B-3elzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		7 TYR A  14
VAL A  27
LYS A  30
GLY A  31
PHE A  34
LEU A 123
ARG A 125
 CHD  A 151 (-4.9A)
CHD  A 152 ( 4.3A)
CHD  A 152 ( 4.1A)
CHD  A 151 (-3.6A)
CHD  A 151 ( 4.6A)
CHD  A 151 (-4.2A)
CHD  A 151 (-4.1A)
 1.15A 3em0B-3elzA:
23.6		 3em0B-3elzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax) 		PF00962
(A_deaminase) 		5 ILE A 144
ILE A 105
VAL A 104
PHE A  49
LEU A  47
 None
None
None
None
MCF  A 372 (-4.3A)
 1.02A 3em0B-3ewdA:
undetectable		 3em0B-3ewdA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7p PLECTIN-1

(Homo sapiens) 		PF00307
(CH) 		5 ILE A 147
ILE A 152
GLY A 100
LEU A 106
LEU A 137
 None
 1.08A 3em0B-3f7pA:
undetectable		 3em0B-3f7pA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyq RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE

(Streptomyces
cyaneus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		5 ILE A 111
ILE A 146
VAL A 148
LEU A 253
LEU A 171
 None
 1.05A 3em0B-3gyqA:
undetectable		 3em0B-3gyqA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyf REVERSE
TRANSCRIPTASE/RNASEH

(Escherichia
coli;
Human
immunodeficiency
virus 1) 		PF00075
(RNase_H) 		5 ILE A 521
ILE A 482
VAL A 442
GLY A 444
LEU A 469
 None
 1.15A 3em0B-3hyfA:
undetectable		 3em0B-3hyfA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T

(Saccharomyces
cerevisiae) 		PF00149
(Metallophos)
PF08321
(PPP5) 		5 ILE A 469
GLY A 440
PHE A 453
LEU A 449
ARG A 432
 None
 1.10A 3em0B-3icfA:
undetectable		 3em0B-3icfA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T

(Saccharomyces
cerevisiae) 		PF00149
(Metallophos)
PF08321
(PPP5) 		5 ILE A 490
ILE A 469
VAL A 246
GLY A 248
ARG A 437
 None
 1.18A 3em0B-3icfA:
undetectable		 3em0B-3icfA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Enterococcus
faecalis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A  39
ILE A  45
GLY A 163
PHE A 147
LEU A 216
 None
 1.17A 3em0B-3il4A:
1.4		 3em0B-3il4A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jaz VIRAL STRUCTURAL
PROTEIN 5

(Cypovirus 1) 		no annotation 5 TYR D 134
ILE D 198
PHE D 287
LEU D 283
LEU D 137
 None
 1.12A 3em0B-3jazD:
undetectable		 3em0B-3jazD:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kar KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		5 ILE A 549
ILE A 560
VAL A 563
PHE A 519
LEU A 684
 None
 1.14A 3em0B-3karA:
1.3		 3em0B-3karA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb5 TRIPARTITE
MOTIF-CONTAINING
PROTEIN 72

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 TYR A 346
VAL A 349
GLY A 414
PHE A 426
LEU A 424
 None
 1.10A 3em0B-3kb5A:
undetectable		 3em0B-3kb5A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		5 ILE A 245
ILE A 270
GLY A 268
LEU A 190
PRO A 183
 None
 1.17A 3em0B-3kh5A:
undetectable		 3em0B-3kh5A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		5 ILE A 105
ILE A 155
GLY A 152
LEU A   7
ARG A  95
 None
 1.08A 3em0B-3koyA:
undetectable		 3em0B-3koyA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ku0 RIBOSOME-INACTIVATIN
G PROTEIN GELONIN

(Suregada
multiflora) 		PF00161
(RIP) 		5 ILE A 240
LYS A 197
GLY A 199
LEU A  39
ARG A 206
 None
 1.06A 3em0B-3ku0A:
undetectable		 3em0B-3ku0A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		5 TYR A 113
CYH A  88
ILE A 305
VAL A 104
GLY A 106
 None
 1.06A 3em0B-3ll8A:
undetectable		 3em0B-3ll8A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lod PUTATIVE ACYL-COA
N-ACYLTRANSFERASE

(Klebsiella
pneumoniae) 		PF00583
(Acetyltransf_1) 		5 ILE A   4
ILE A  52
VAL A  60
LEU A 123
LEU A  97
 None
 1.09A 3em0B-3lodA:
undetectable		 3em0B-3lodA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7g TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13404
(HTH_AsnC-type) 		5 ILE A 114
ILE A 105
VAL A 147
GLY A 150
ARG A  76
 None
 0.95A 3em0B-3m7gA:
undetectable		 3em0B-3m7gA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9x D-XYLOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		5 ILE A   5
VAL A  61
LYS A  85
PHE A 100
PRO A 264
 None
 1.16A 3em0B-3m9xA:
undetectable		 3em0B-3m9xA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF01053
(Cys_Met_Meta_PP) 		5 ILE A 346
ILE A 387
VAL A 321
LEU A 325
LEU A 340
 None
 1.07A 3em0B-3ndnA:
undetectable		 3em0B-3ndnA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		5 CYH B 341
ILE B 340
VAL B 504
GLY B 500
LEU B 304
 None
 1.08A 3em0B-3o8oB:
undetectable		 3em0B-3o8oB:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8q SHIKIMATE
5-DEHYDROGENASE I
ALPHA

(Vibrio cholerae) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 ILE B 150
VAL B 111
GLY B 107
LEU B  85
LEU B 163
 None
 1.04A 3em0B-3o8qB:
undetectable		 3em0B-3o8qB:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3out GLUTAMATE RACEMASE

(Francisella
tularensis) 		PF01177
(Asp_Glu_race) 		5 TYR A  34
ILE A  14
GLY A  36
LEU A 257
LEU A 250
 None
 1.07A 3em0B-3outA:
undetectable		 3em0B-3outA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpd CUTINASE 1

(Aspergillus
oryzae) 		PF01083
(Cutinase) 		5 ILE A 120
ILE A  43
VAL A  79
LEU A 152
LEU A 208
 None
 0.96A 3em0B-3qpdA:
undetectable		 3em0B-3qpdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		6 ILE A 185
ILE A 211
VAL A 237
LYS A 240
GLY A 241
LEU A 204
 None
 1.38A 3em0B-3t6qA:
undetectable		 3em0B-3t6qA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT

(Thermus
aquaticus) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		5 ILE B 200
VAL B 194
LYS B  98
LEU B 117
LEU B 175
 None
 1.06A 3em0B-3ufxB:
undetectable		 3em0B-3ufxB:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Cupriavidus
necator) 		PF01370
(Epimerase) 		5 ILE A 192
ILE A 257
VAL A 261
GLY A 263
ARG A 267
 None
 1.15A 3em0B-3wmxA:
undetectable		 3em0B-3wmxA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00753
(Lactamase_B) 		5 TYR A  34
ILE A 194
GLY A 198
LEU A   5
LEU A  11
 None
 1.17A 3em0B-4ad9A:
undetectable		 3em0B-4ad9A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Escherichia
coli) 		PF04378
(RsmJ) 		5 TYR A 192
ILE A 219
ILE A 216
LYS A 185
GLY A 183
 None
 1.05A 3em0B-4bluA:
undetectable		 3em0B-4bluA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		5 ILE A 530
ILE A 532
VAL A 504
GLY A 510
LEU A 463
 None
None
None
SO4  A1538 (-3.2A)
None
 1.12A 3em0B-4bqhA:
undetectable		 3em0B-4bqhA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0b MALATE DEHYDROGENASE

(Vibrio
vulnificus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A  75
GLY A 145
PHE A 144
LEU A 238
LEU A  16
 None
 1.13A 3em0B-4e0bA:
undetectable		 3em0B-4e0bA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etp KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		5 ILE A 549
ILE A 560
VAL A 563
PHE A 519
LEU A 684
 None
 1.10A 3em0B-4etpA:
undetectable		 3em0B-4etpA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1k TRIOSEPHOSPHATE
ISOMERASE

(Burkholderia
thailandensis) 		PF00121
(TIM) 		5 ILE A  42
VAL A   9
GLY A  11
LEU A  25
LEU A  58
 None
None
None
EDO  A 303 ( 4.5A)
None
 0.91A 3em0B-4g1kA:
undetectable		 3em0B-4g1kA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		5 ILE A 114
ILE A 105
VAL A 147
GLY A 150
ARG A  76
 None
 0.99A 3em0B-4gfjA:
undetectable		 3em0B-4gfjA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhx TOXIN COREGULATED
PILUS BIOSYNTHESIS
PROTEIN E

(Vibrio cholerae) 		PF00482
(T2SSF) 		5 TYR A  13
ILE A  87
ILE A  78
VAL A  75
LEU A  16
 None
 1.14A 3em0B-4hhxA:
undetectable		 3em0B-4hhxA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		5 ILE A 589
GLY A 999
PHE A1034
LEU A 492
LEU A 572
 None
 1.06A 3em0B-4hpfA:
undetectable		 3em0B-4hpfA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 355
VAL A 129
LEU A 270
PRO A 295
LEU A 361
 None
 1.10A 3em0B-4hpnA:
undetectable		 3em0B-4hpnA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		5 TYR A 446
CYH A 421
ILE A 638
VAL A 437
GLY A 439
 None
 1.12A 3em0B-4il1A:
undetectable		 3em0B-4il1A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Vibrio cholerae) 		no annotation 5 ILE D 238
ILE D 105
GLY D 145
LEU D  86
ARG D 151
 None
 1.18A 3em0B-4jrmD:
0.5		 3em0B-4jrmD:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 5 ILE A 413
VAL A 402
LEU A 561
LEU A 540
ARG A 372
 None
 1.15A 3em0B-4jzaA:
undetectable		 3em0B-4jzaA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis) 		PF00724
(Oxidored_FMN) 		5 ILE A 280
VAL A 308
LEU A 199
PRO A 243
LEU A 222
 None
 1.16A 3em0B-4m5pA:
undetectable		 3em0B-4m5pA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofq PUTATIVE CELL
SURFACE PROTEIN

(Streptococcus
pyogenes) 		PF16364
(Antigen_C) 		5 TYR A1197
ILE A1221
GLY A1183
LEU A1252
LEU A1259
 None
 0.99A 3em0B-4ofqA:
undetectable		 3em0B-4ofqA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		5 CYH A  48
ILE A  46
VAL A 236
GLY A  27
LEU A  44
 None
 1.18A 3em0B-4otkA:
undetectable		 3em0B-4otkA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q58 PLECTIN

(Homo sapiens) 		PF00307
(CH) 		5 ILE A 120
ILE A 125
GLY A  73
LEU A  79
LEU A 110
 None
 1.03A 3em0B-4q58A:
undetectable		 3em0B-4q58A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxa SMALL G PROTEIN
SIGNALING MODULATOR
1

(Mus musculus) 		no annotation 5 ILE B 318
ILE B 323
PHE B 419
LEU B 363
LEU B 280
 None
 1.17A 3em0B-4qxaB:
undetectable		 3em0B-4qxaB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		5 ILE A  37
ILE A  94
VAL A 120
LEU A 333
PRO A 295
 None
 1.18A 3em0B-4rs3A:
undetectable		 3em0B-4rs3A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		5 ILE A 527
ILE A 189
GLY A 571
PHE A 541
LEU A 549
 None
 1.11A 3em0B-4wgkA:
2.0		 3em0B-4wgkA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 TYR A 682
ILE A 671
GLY A 784
PHE A 781
LEU A 684
 None
None
None
NAG  A 903 (-3.7A)
None
 1.18A 3em0B-4xhjA:
undetectable		 3em0B-4xhjA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzk TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE

(Streptomyces
blastmyceticus) 		PF11991
(Trp_DMAT) 		5 ILE A 369
VAL A 323
GLY A 325
LEU A 352
ARG A 331
 None
 1.01A 3em0B-4yzkA:
2.3		 3em0B-4yzkA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1p CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		5 TYR A 219
ILE A 243
GLY A 205
LEU A 274
LEU A 281
 None
 1.04A 3em0B-4z1pA:
undetectable		 3em0B-4z1pA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z23 CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		5 TYR A 219
ILE A 243
GLY A 205
LEU A 274
LEU A 281
 None
 1.12A 3em0B-4z23A:
undetectable		 3em0B-4z23A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5

(Homo sapiens) 		PF00307
(CH) 		5 ILE A 123
ILE A 128
GLY A  76
LEU A  82
LEU A 113
 None
 1.00A 3em0B-4z6gA:
undetectable		 3em0B-4z6gA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah0 LIPASE

(Pelosinus
fermentans) 		no annotation 5 TYR A  40
CYH A 376
GLY A  26
PHE A  27
LEU A 197
 None
 1.16A 3em0B-5ah0A:
undetectable		 3em0B-5ah0A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Coccidioides
immitis) 		PF00149
(Metallophos) 		5 TYR A 131
CYH A 106
ILE A 323
VAL A 122
GLY A 124
 None
 1.11A 3em0B-5b8iA:
undetectable		 3em0B-5b8iA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmc ML032222A IGLUR

(Mnemiopsis
leidyi) 		PF10613
(Lig_chan-Glu_bd) 		5 ILE A 186
VAL A 140
GLY A 165
LEU A 131
LEU A 124
 None
 0.96A 3em0B-5cmcA:
undetectable		 3em0B-5cmcA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm4 METHYLTRANSFERASE
DOMAIN FAMILY

(Bacillus
pumilus) 		PF13489
(Methyltransf_23) 		5 ILE A   2
ILE A   6
GLY A 133
LEU A 250
LEU A 198
 None
None
5DA  A 302 (-3.5A)
None
None
 1.07A 3em0B-5dm4A:
undetectable		 3em0B-5dm4A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ILE A  60
GLY A  16
PHE A  19
LEU A   6
LEU A  57
 None
 1.18A 3em0B-5eioA:
undetectable		 3em0B-5eioA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		5 ILE A 382
ILE A 380
VAL A 327
LYS A 330
ARG A 319
 None
 1.13A 3em0B-5gqtA:
2.1		 3em0B-5gqtA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7z PUTATIVE SECRETED
ENDOGLYCOSYLCERAMIDA
SE

(Rhodococcus
hoagii) 		PF00150
(Cellulase) 		5 ILE A 254
VAL A 247
GLY A 194
LEU A 109
ARG A 199
 None
 1.14A 3em0B-5j7zA:
undetectable		 3em0B-5j7zA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Arabidopsis
thaliana) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5)
PF13431
(TPR_17) 		5 ILE A 448
GLY A 419
PHE A 432
LEU A 428
ARG A 411
 None
 1.14A 3em0B-5jjtA:
undetectable		 3em0B-5jjtA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae) 		PF00154
(RecA) 		5 CYH A 136
ILE A 100
ILE A 148
LEU A 222
LEU A 133
 None
 1.13A 3em0B-5jrjA:
undetectable		 3em0B-5jrjA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR

(Bacteria
Latreille et
al. 1825) 		no annotation 5 ILE A  68
GLY A 106
PHE A 107
PRO A  91
LEU A  65
 None
 1.13A 3em0B-5u9eA:
undetectable		 3em0B-5u9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xly CYCLIC DIGUANOSINE
MONOPHOSPHATE-BINDIN
G PROTEIN PA4608

(Pseudomonas
aeruginosa) 		PF07238
(PilZ) 		5 ILE B  73
ILE B  41
LEU B  68
LEU B  23
ARG B  60
 None
 1.13A 3em0B-5xlyB:
undetectable		 3em0B-5xlyB:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9h SAFD,PUTATIVE OUTER
MEMBRANE
PROTEIN,PUTATIVE
OUTER MEMBRANE
PROTEIN,PUTATIVE
OUTER MEMBRANE
PROTEIN

(Salmonella
enterica) 		no annotation 5 ILE A  88
ILE A 166
VAL A  31
PHE A 118
LEU A  92
 None
 1.10A 3em0B-5y9hA:
undetectable		 3em0B-5y9hA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 6 ILE A 829
VAL A 772
GLY A 803
PHE A 802
LEU A1054
LEU A1061
 None
 1.37A 3em0B-5zalA:
undetectable		 3em0B-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aoo MALATE DEHYDROGENASE

(Haemophilus
influenzae) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A  75
GLY A 145
PHE A 144
LEU A 238
LEU A  16
 None
 1.17A 3em0B-6aooA:
undetectable		 3em0B-6aooA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 420
ILE A 376
GLY A 416
LEU A 313
PRO A 303
 None
 1.05A 3em0B-6az0A:
undetectable		 3em0B-6az0A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0m HEMAGGLUTININ-NEURAM
INIDASE

(Human
respirovirus 3) 		no annotation 5 ILE A 437
ILE A 436
GLY A 488
PRO A 153
ARG A 411
 None
 0.98A 3em0B-6c0mA:
0.7		 3em0B-6c0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 ILE A  23
VAL A  58
LYS A  57
GLY A  56
LEU A 226
 None
 1.12A 3em0B-6ci9A:
undetectable		 3em0B-6ci9A:
undetectable