SIMILAR PATTERNS OF AMINO ACIDS FOR 3EM0_B_CHDB150

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME

(Escherichia
coli) 		PF00994
(MoCF_biosynth) 		5 THR A  76
VAL A  70
LEU A  61
ILE A 129
THR A  57
 SO4  A 201 (-2.8A)
None
None
None
None
 1.34A 3em0B-1di6A:
undetectable		 3em0B-1di6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnv GALLERIA MELLONELLA
DENSOVIRUS CAPSID
PROTEIN

(Lepidopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		5 ASN A 111
THR A 359
VAL A 245
LEU A 250
THR A 135
 None
 1.34A 3em0B-1dnvA:
undetectable		 3em0B-1dnvA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdw 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		5 PHE A 240
ILE A 183
VAL A  66
LEU A  64
THR A  35
 None
 1.28A 3em0B-1fdwA:
undetectable		 3em0B-1fdwA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I

(Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 PHE A 127
ILE A  61
PHE A 301
VAL A 467
THR A 464
 None
 1.38A 3em0B-1i1qA:
2.3		 3em0B-1i1qA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		5 ILE A 493
GLN A 489
ASN A 577
THR A 641
PHE A 619
 None
 1.33A 3em0B-1k1xA:
2.2		 3em0B-1k1xA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ASN A 244
MET A 201
PHE A 267
LEU A  52
ILE A 175
 None
 0.95A 3em0B-1kcwA:
undetectable		 3em0B-1kcwA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lv7 FTSH

(Escherichia
coli) 		PF00004
(AAA) 		5 PHE A 216
ILE A 250
MET A 281
VAL A 259
ILE A 256
 None
 1.39A 3em0B-1lv7A:
undetectable		 3em0B-1lv7A:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1u GASTROTROPIN

(Homo sapiens) 		PF14651
(Lipocalin_7) 		5 PHE A  17
TRP A  49
ASN A  61
VAL A  83
LEU A  90
 None
 0.87A 3em0B-1o1uA:
16.5		 3em0B-1o1uA:
56.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1u GASTROTROPIN

(Homo sapiens) 		PF14651
(Lipocalin_7) 		5 PHE A  17
TRP A  49
GLN A  51
VAL A  83
LEU A  90
 None
 0.73A 3em0B-1o1uA:
16.5		 3em0B-1o1uA:
56.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		5 ILE A 193
MET A 241
PHE A 247
LEU A 202
ILE A 283
 None
 1.31A 3em0B-1o5tA:
0.0		 3em0B-1o5tA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9m INTERLEUKIN-6
RECEPTOR BETA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF06328
(Lep_receptor_Ig)
PF09240
(IL6Ra-bind) 		5 ASN A  92
VAL A  44
LEU A  84
ILE A  43
THR A  85
 None
 1.27A 3em0B-1p9mA:
undetectable		 3em0B-1p9mA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Ovis aries) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 PHE A 156
ILE A 152
MET A  60
LEU A  10
ILE A   8
 None
 1.15A 3em0B-1pgpA:
undetectable		 3em0B-1pgpA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ILE A 242
MET A 286
PHE A 290
LEU A 327
THR A 330
 None
 1.17A 3em0B-1u0uA:
undetectable		 3em0B-1u0uA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		5 PHE A 488
VAL A 342
LEU A  26
ILE A 340
THR A  70
 None
 1.19A 3em0B-1v4gA:
undetectable		 3em0B-1v4gA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE

(Sulfolobus
solfataricus) 		PF00701
(DHDPS) 		5 ASN A 245
VAL A 232
LEU A 203
ILE A 233
THR A 207
 None
 1.25A 3em0B-1w3iA:
undetectable		 3em0B-1w3iA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybd URIDYLATE KINASE

(Neisseria
meningitidis) 		PF00696
(AA_kinase) 		5 ILE A 220
PHE A  95
VAL A 104
ILE A 133
THR A  84
 None
 1.37A 3em0B-1ybdA:
undetectable		 3em0B-1ybdA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydw AX110P-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01408
(GFO_IDH_MocA) 		5 PHE A 202
ILE A 335
THR A 129
VAL A 262
ILE A 251
 None
 1.22A 3em0B-1ydwA:
undetectable		 3em0B-1ydwA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypf GMP REDUCTASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		5 PHE A  63
VAL A 127
LEU A 157
ILE A 117
THR A 165
 None
 1.28A 3em0B-1ypfA:
undetectable		 3em0B-1ypfA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zan FAB AD11 HEAVY CHAIN
FAB AD11 LIGHT CHAIN

(Rattus
norvegicus;
Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 ILE H 210
GLN L 125
VAL H 169
LEU L 161
THR L 179
 None
 1.37A 3em0B-1zanH:
undetectable		 3em0B-1zanH:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv9 CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		5 ILE A  31
MET A  41
THR A 143
PHE A 130
VAL A 116
 None
 1.25A 3em0B-1zv9A:
undetectable		 3em0B-1zv9A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zx5 MANNOSEPHOSPHATE
ISOMERASE, PUTATIVE

(Archaeoglobus
fulgidus) 		PF01238
(PMI_typeI) 		5 PHE A  41
ILE A   7
PHE A 283
VAL A 234
ILE A 292
 None
 1.34A 3em0B-1zx5A:
undetectable		 3em0B-1zx5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhr FTSH

(Thermus
thermophilus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		5 PHE A 217
ILE A 251
PHE A 317
VAL A 260
ILE A 257
 None
 1.34A 3em0B-2dhrA:
undetectable		 3em0B-2dhrA:
13.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f73 FATTY ACID-BINDING
PROTEIN, LIVER

(Homo sapiens) 		PF14651
(Lipocalin_7) 		5 ASN A  61
THR A  73
VAL A  83
LEU A  91
THR A 102
 None
 0.77A 3em0B-2f73A:
17.7		 3em0B-2f73A:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f73 FATTY ACID-BINDING
PROTEIN, LIVER

(Homo sapiens) 		PF14651
(Lipocalin_7) 		6 PHE A  18
ILE A  22
ASN A  61
VAL A  83
LEU A  91
THR A 102
 None
 0.43A 3em0B-2f73A:
17.7		 3em0B-2f73A:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 PHE A 210
ILE A 247
PHE A 170
VAL A 439
LEU A 434
 None
 1.33A 3em0B-2g3nA:
undetectable		 3em0B-2g3nA:
11.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lba BABP PROTEIN

(Gallus gallus) 		PF14651
(Lipocalin_7) 		7 PHE A  17
ILE A  21
MET A  71
THR A  73
PHE A  79
VAL A  83
THR A 100
 CHO  A 200 ( 4.3A)
CHO  A 201 ( 4.3A)
CHO  A 201 (-2.4A)
CHO  A 201 (-2.8A)
CHO  A 201 (-3.5A)
CHO  A 201 ( 4.0A)
None
 1.42A 3em0B-2lbaA:
19.7		 3em0B-2lbaA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lba BABP PROTEIN

(Gallus gallus) 		PF14651
(Lipocalin_7) 		8 PHE A  17
ILE A  21
TRP A  49
ASN A  61
MET A  71
THR A  73
PHE A  79
VAL A  83
 CHO  A 200 ( 4.3A)
CHO  A 201 ( 4.3A)
CHO  A 201 (-2.9A)
CHO  A 201 ( 3.5A)
CHO  A 201 (-2.4A)
CHO  A 201 (-2.8A)
CHO  A 201 (-3.5A)
CHO  A 201 ( 4.0A)
 0.79A 3em0B-2lbaA:
19.7		 3em0B-2lbaA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lba BABP PROTEIN

(Gallus gallus) 		PF14651
(Lipocalin_7) 		7 TRP A  49
GLN A  51
ASN A  61
MET A  71
THR A  73
PHE A  79
VAL A  83
 CHO  A 201 (-2.9A)
CHO  A 201 ( 3.4A)
CHO  A 201 ( 3.5A)
CHO  A 201 (-2.4A)
CHO  A 201 (-2.8A)
CHO  A 201 (-3.5A)
CHO  A 201 ( 4.0A)
 0.95A 3em0B-2lbaA:
19.7		 3em0B-2lbaA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lkk FATTY ACID-BINDING
PROTEIN, LIVER

(Homo sapiens) 		PF14651
(Lipocalin_7) 		5 ILE A  22
THR A  73
VAL A  83
LEU A  91
THR A 102
 None
None
None
None
OLA  A 129 (-2.7A)
 0.87A 3em0B-2lkkA:
16.9		 3em0B-2lkkA:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lkk FATTY ACID-BINDING
PROTEIN, LIVER

(Homo sapiens) 		PF14651
(Lipocalin_7) 		5 PHE A  18
ILE A  22
VAL A  83
LEU A  91
THR A 102
 OLA  A 129 ( 4.8A)
None
None
None
OLA  A 129 (-2.7A)
 0.56A 3em0B-2lkkA:
16.9		 3em0B-2lkkA:
40.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqi CALPAIN-1 CATALYTIC
SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		5 ILE A 263
MET A 294
PHE A 334
LEU A 227
THR A 346
 None
 1.16A 3em0B-2nqiA:
undetectable		 3em0B-2nqiA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		5 PHE A 142
ILE A 104
GLN A  58
THR A  99
THR A  65
 None
 1.30A 3em0B-2q6uA:
undetectable		 3em0B-2q6uA:
15.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		6 PHE A  17
ILE A  21
ASN A  60
THR A  72
VAL A  82
LEU A  89
 None
GOL  A 145 ( 4.8A)
IPA  A 141 ( 4.7A)
GOL  A 145 (-3.2A)
None
IPA  A 142 ( 4.7A)
 0.99A 3em0B-2qo4A:
20.2		 3em0B-2qo4A:
45.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei) 		PF00303
(Thymidylat_synt) 		5 GLN A 217
THR A 254
VAL A  13
LEU A 260
ILE A  31
 UFP  A 529 ( 4.7A)
None
None
None
None
 1.39A 3em0B-2tddA:
undetectable		 3em0B-2tddA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 PHE G 583
ILE G 766
THR G 680
VAL G 607
ILE G 617
 None
 1.25A 3em0B-2uv8G:
undetectable		 3em0B-2uv8G:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgy CYTOCHROME P450 130

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 PHE A 108
GLN A 363
PHE A 166
VAL A 174
THR A 247
 None
None
None
None
HEM  A 450 (-3.6A)
 1.26A 3em0B-2wgyA:
undetectable		 3em0B-2wgyA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		5 ILE B  89
ASN B  40
THR B  56
LEU B 174
THR B 173
 None
 1.11A 3em0B-2xdqB:
undetectable		 3em0B-2xdqB:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Thermotoga
maritima) 		PF00467
(KOW)
PF02357
(NusG) 		5 PHE A 232
ILE A 277
VAL A 349
LEU A 329
ILE A 307
 None
 1.14A 3em0B-2xhcA:
undetectable		 3em0B-2xhcA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		5 PHE A 539
ILE A 550
MET A 577
VAL A 598
LEU A 523
 None
 1.38A 3em0B-2yhbA:
undetectable		 3em0B-2yhbA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		5 ILE A  23
PHE A  35
VAL A 449
LEU A 391
THR A 388
 None
 1.28A 3em0B-3aivA:
undetectable		 3em0B-3aivA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akz GLUTAMYL-TRNA
SYNTHETASE 2

(Thermotoga
maritima) 		no annotation 5 ILE B 365
THR B 453
VAL B 444
LEU B 433
THR B 429
 None
 1.19A 3em0B-3akzB:
undetectable		 3em0B-3akzB:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		5 PHE A 273
ILE A 325
THR A 340
VAL A 226
ILE A 227
 None
 0.97A 3em0B-3e53A:
undetectable		 3em0B-3e53A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ect HEXAPEPTIDE-REPEAT
CONTAINING-ACETYLTRA
NSFERASE

(Vibrio cholerae) 		PF00132
(Hexapep)
PF12464
(Mac) 		5 MET A  88
THR A 106
PHE A 108
LEU A  56
ILE A  96
 None
 1.31A 3em0B-3ectA:
undetectable		 3em0B-3ectA:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		11 PHE A  17
ILE A  21
TRP A  49
GLN A  51
ASN A  61
MET A  71
PHE A  79
VAL A  83
LEU A  90
ILE A  92
THR A 101
 None
CHD  A 153 ( 4.1A)
CHD  A 150 (-3.5A)
CHD  A 150 ( 3.7A)
CHD  A 150 ( 4.0A)
CHD  A 150 ( 3.7A)
CHD  A 153 ( 4.9A)
CHD  A 150 (-4.4A)
CHD  A 150 (-4.4A)
CHD  A 150 (-3.9A)
CHD  A 150 (-2.9A)
 0.77A 3em0B-3elzA:
23.6		 3em0B-3elzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		11 PHE A  17
TRP A  49
GLN A  51
ASN A  61
MET A  71
THR A  73
PHE A  79
VAL A  83
LEU A  90
ILE A  92
THR A 101
 None
CHD  A 150 (-3.5A)
CHD  A 150 ( 3.7A)
CHD  A 150 ( 4.0A)
CHD  A 150 ( 3.7A)
CHD  A 200 (-3.1A)
CHD  A 153 ( 4.9A)
CHD  A 150 (-4.4A)
CHD  A 150 (-4.4A)
CHD  A 150 (-3.9A)
CHD  A 150 (-2.9A)
 0.65A 3em0B-3elzA:
23.6		 3em0B-3elzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbx GLUTAMATE
DECARBOXYLASE 1

(Arabidopsis
thaliana) 		PF00282
(Pyridoxal_deC) 		5 PHE A 425
ILE A 421
PHE A 378
VAL A 440
ILE A 437
 None
 1.08A 3em0B-3hbxA:
undetectable		 3em0B-3hbxA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Lactobacillus
acidophilus) 		PF04909
(Amidohydro_2) 		5 PHE A  31
ILE A  27
ASN A 106
THR A  69
ILE A 102
 None
 1.33A 3em0B-3ij6A:
undetectable		 3em0B-3ij6A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldh LACTATE
DEHYDROGENASE

(Squalus
acanthias) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLN A 314
VAL A 285
LEU A 322
ILE A 281
THR A 321
 None
 1.35A 3em0B-3ldhA:
undetectable		 3em0B-3ldhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		5 GLN A 298
MET A  59
LEU A  83
ILE A  87
THR A  72
 None
 1.33A 3em0B-3mmtA:
undetectable		 3em0B-3mmtA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		5 ILE A 176
MET A  59
LEU A  83
ILE A  87
THR A  72
 None
 1.30A 3em0B-3mmtA:
undetectable		 3em0B-3mmtA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n28 PHOSPHOSERINE
PHOSPHATASE

(Vibrio cholerae) 		PF00702
(Hydrolase) 		5 THR A 105
VAL A  68
LEU A   9
ILE A  11
THR A   8
 None
 1.18A 3em0B-3n28A:
undetectable		 3em0B-3n28A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		5 MET A 352
THR A 336
PHE A 264
VAL A 394
ILE A 436
 None
 1.20A 3em0B-3nd0A:
undetectable		 3em0B-3nd0A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfe PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE FAMILY
PROTEIN

(Coccidioides
immitis) 		PF00701
(DHDPS) 		5 PHE A  55
PHE A 127
VAL A 170
LEU A 172
THR A 173
 None
 1.24A 3em0B-3qfeA:
undetectable		 3em0B-3qfeA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 PHE A 680
TRP A 654
VAL A 520
ILE A 549
THR A 592
 None
 1.18A 3em0B-3rimA:
undetectable		 3em0B-3rimA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shq UBLCP1

(Drosophila
melanogaster) 		PF00240
(ubiquitin)
PF03031
(NIF) 		5 PHE A 303
ILE A 296
PHE A 172
VAL A 210
ILE A 182
 None
 1.07A 3em0B-3shqA:
undetectable		 3em0B-3shqA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsy SORTILIN-RELATED
RECEPTOR

(Homo sapiens) 		PF15901
(Sortilin_C)
PF15902
(Sortilin-Vps10) 		5 ILE A 548
GLN A 614
THR A 588
VAL A 583
ILE A 552
 None
 1.35A 3em0B-3wsyA:
2.0		 3em0B-3wsyA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CMR6

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		5 ILE H  35
VAL H 110
LEU H 113
ILE H 123
THR H 121
 None
None
C  I  28 ( 4.7A)
None
None
 1.28A 3em0B-3x1lH:
undetectable		 3em0B-3x1lH:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zcw KINESIN-LIKE PROTEIN
KIF11

(Homo sapiens) 		PF00225
(Kinesin) 		5 ILE A 319
MET A 115
VAL A  86
LEU A  90
ILE A 101
 None
 1.34A 3em0B-3zcwA:
undetectable		 3em0B-3zcwA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfp N-TERMINAL PROTEASE
NPRO

(Pestivirus H) 		PF05550
(Peptidase_C53) 		5 PHE A 106
VAL A  83
LEU A  81
ILE A 163
THR A 166
 None
 1.00A 3em0B-3zfpA:
undetectable		 3em0B-3zfpA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhl ARGININE KINASE

(Litopenaeus
vannamei) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 PHE A 136
MET A 331
THR A 278
LEU A  26
ILE A  86
 None
 1.37A 3em0B-4bhlA:
undetectable		 3em0B-4bhlA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bin N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMIC

(Escherichia
coli) 		PF01520
(Amidase_3)
PF11741
(AMIN) 		5 PHE A 407
ILE A 188
VAL A 279
LEU A 340
ILE A 370
 None
 1.26A 3em0B-4binA:
undetectable		 3em0B-4binA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		5 ILE A 121
TRP A 153
THR A  29
ILE A   9
THR A 132
 None
 1.10A 3em0B-4cnkA:
undetectable		 3em0B-4cnkA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 ILE A  97
MET A 399
THR A 457
LEU A 447
ILE A 424
 None
 1.23A 3em0B-4cpnA:
undetectable		 3em0B-4cpnA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1t METALLO-B-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		5 ILE A  99
THR A 110
VAL A 189
LEU A 201
THR A 115
 None
 1.30A 3em0B-4d1tA:
undetectable		 3em0B-4d1tA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5b DR_1245 PROTEIN

(Deinococcus
radiodurans) 		PF10722
(YbjN) 		5 ILE A  24
GLN A 152
PHE A 119
VAL A 126
ILE A  62
 None
 1.21A 3em0B-4h5bA:
3.1		 3em0B-4h5bA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 5 ILE B 424
ASN B 364
VAL B 342
LEU B 590
THR B 591
 None
 1.38A 3em0B-4iglB:
2.4		 3em0B-4iglB:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jja HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		5 ILE A 139
ASN A 202
VAL A 217
LEU A 385
ILE A 157
 None
None
GOL  A 400 (-4.0A)
GOL  A 400 (-4.7A)
None
 1.09A 3em0B-4jjaA:
undetectable		 3em0B-4jjaA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		5 ILE A 202
MET A 262
VAL A  45
LEU A  48
THR A  49
 None
 1.36A 3em0B-4kpnA:
undetectable		 3em0B-4kpnA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l63 ECXA

(Escherichia
coli) 		PF16313
(DUF4953) 		5 PHE A 142
ILE A 137
THR A 125
LEU A 219
ILE A 217
 None
 1.27A 3em0B-4l63A:
undetectable		 3em0B-4l63A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 175
GLN A 381
ASN A 105
LEU A 132
ILE A  68
 None
None
ZN  A 501 ( 4.9A)
None
None
 1.29A 3em0B-4mmoA:
undetectable		 3em0B-4mmoA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p53 CYCLASE

(Streptomyces
hygroscopicus) 		PF01761
(DHQ_synthase) 		5 ASN A 175
VAL A 109
LEU A 142
ILE A 139
THR A 172
 None
 1.33A 3em0B-4p53A:
undetectable		 3em0B-4p53A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		5 PHE A 354
ILE A 358
ASN A 397
VAL A 174
ILE A 372
 None
 1.16A 3em0B-4qbuA:
undetectable		 3em0B-4qbuA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 867
MET A 665
VAL A 675
LEU A 818
ILE A 674
 None
P30  A1001 ( 3.7A)
None
P30  A1001 (-4.6A)
None
 1.32A 3em0B-4rt7A:
undetectable		 3em0B-4rt7A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 PHE A 272
ILE A 267
VAL A 211
LEU A 209
ILE A 237
 None
 1.09A 3em0B-4v2dA:
undetectable		 3em0B-4v2dA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B

(Roseobacter
denitrificans) 		PF00115
(COX1) 		5 PHE A  13
GLN A  90
ASN A 144
VAL A 149
LEU A 162
 None
 1.25A 3em0B-4xydA:
undetectable		 3em0B-4xydA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 NEQ263

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab) 		5 PHE B 383
ILE B 400
GLN B 146
ASN B 150
LEU B 124
 None
 1.27A 3em0B-5bn4B:
undetectable		 3em0B-5bn4B:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		5 PHE A 321
ILE A 270
PHE A 309
VAL A 383
ILE A 387
 None
 1.37A 3em0B-5btrA:
undetectable		 3em0B-5btrA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE
PROTEASOME SUBUNIT
ALPHA TYPE

(Plasmodium
falciparum;
Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 PHE C 134
ILE C 136
ASN D  77
VAL D  82
THR C 122
 None
 1.28A 3em0B-5fmgC:
undetectable		 3em0B-5fmgC:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5isu LMO0135 PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		5 PHE A 181
ILE A 187
GLN A  67
VAL A 213
LEU A 215
 None
 1.24A 3em0B-5isuA:
undetectable		 3em0B-5isuA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		5 PHE A 454
THR A 467
VAL A 391
LEU A 389
ILE A 416
 None
 1.28A 3em0B-5j44A:
undetectable		 3em0B-5j44A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh1 ALDOSE REDUCTASE,
AKR4C7

(Zea mays) 		PF00248
(Aldo_ket_red) 		5 ILE A 223
GLN A 283
THR A 211
VAL A 177
LEU A 188
 None
 1.30A 3em0B-5jh1A:
undetectable		 3em0B-5jh1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5z PARA

(Sulfolobus sp.
NOB8H2) 		PF13614
(AAA_31) 		5 ILE A 107
THR A 149
LEU A 139
ILE A  38
THR A  21
 None
 1.25A 3em0B-5k5zA:
undetectable		 3em0B-5k5zA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga) 		no annotation 5 ILE B 424
ASN B 364
VAL B 342
LEU B 589
THR B 590
 CL  B1002 ( 4.9A)
None
None
None
None
 1.30A 3em0B-5kisB:
3.6		 3em0B-5kisB:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH

(Eremococcus
coleocola) 		PF01566
(Nramp) 		5 PHE A 358
ILE A 354
VAL A 449
LEU A 422
ILE A 418
 None
 1.33A 3em0B-5m8jA:
undetectable		 3em0B-5m8jA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 ASN A 243
MET A 200
PHE A 266
LEU A  52
ILE A 174
 None
 0.79A 3em0B-5n4lA:
undetectable		 3em0B-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 PHE B 220
ILE B 219
LEU B 353
ILE B 337
THR B 243
 None
 1.34A 3em0B-5n8nB:
undetectable		 3em0B-5n8nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmp ISATIN HYDROLASE

(Ralstonia
solanacearum) 		no annotation 5 ILE A 197
THR A 172
VAL A 180
LEU A 216
THR A 215
 None
 1.26A 3em0B-5nmpA:
undetectable		 3em0B-5nmpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN

(Chaetomium
thermophilum) 		no annotation 5 PHE A1790
ILE A1530
VAL A1633
LEU A1661
ILE A1618
 None
 1.28A 3em0B-5nnlA:
undetectable		 3em0B-5nnlA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svw ADAGIO PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 5 ILE B 119
ASN B  53
THR B  22
VAL B  76
ILE B  79
 None
FMN  B5201 (-2.9A)
FMN  B5201 (-2.5A)
FMN  B5201 (-3.8A)
FMN  B5201 ( 3.1A)
 1.37A 3em0B-5svwB:
undetectable		 3em0B-5svwB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 PHE D 182
ILE D 186
VAL D 376
LEU D 366
ILE D 364
 None
 1.35A 3em0B-5tpzD:
undetectable		 3em0B-5tpzD:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 PHE A 531
ILE A 774
PHE A 470
VAL A 474
ILE A 400
 None
 1.15A 3em0B-5uowA:
undetectable		 3em0B-5uowA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 PHE A 138
ILE A   7
ASN A 103
LEU A 190
THR A 191
 None
None
GTP  A 502 (-3.4A)
None
None
 1.38A 3em0B-5w3fA:
undetectable		 3em0B-5w3fA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8q BIS3 BIPHENYL
SYNTHASE

(Malus domestica) 		no annotation 5 ILE A 234
MET A 278
PHE A 282
LEU A 321
THR A 324
 None
 1.35A 3em0B-5w8qA:
undetectable		 3em0B-5w8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1

(Saccharomyces
cerevisiae) 		no annotation 5 PHE A  98
GLN A 160
THR A  76
VAL A 201
THR A 152
 None
 1.35A 3em0B-5y58A:
undetectable		 3em0B-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		5 ILE A 945
GLN A 926
THR A 314
VAL A 327
LEU A 295
 None
 1.32A 3em0B-5y7oA:
undetectable		 3em0B-5y7oA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybw ASPARTATE RACEMASE

(Scapharca
broughtonii) 		no annotation 5 PHE A 238
ILE A 247
MET A 123
LEU A 147
THR A 143
 None
 1.34A 3em0B-5ybwA:
undetectable		 3em0B-5ybwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybw ASPARTATE RACEMASE

(Scapharca
broughtonii) 		no annotation 5 PHE A 238
ILE A 247
VAL A  85
LEU A 147
THR A 143
 None
 1.07A 3em0B-5ybwA:
undetectable		 3em0B-5ybwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 5 PHE A1807
ILE A1787
ASN A1743
VAL A1851
THR A1889
 None
 1.30A 3em0B-6bq1A:
undetectable		 3em0B-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 5 PHE A 374
PHE A  11
VAL A  23
ILE A 403
THR A 413
 None
 1.16A 3em0B-6chjA:
undetectable		 3em0B-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 5 ILE D 368
THR D 140
VAL D 312
LEU D 160
THR D 338
 None
 1.07A 3em0B-6f5dD:
undetectable		 3em0B-6f5dD:
undetectable