SIMILAR PATTERNS OF AMINO ACIDS FOR 3EM0_A_CHDA151_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 CYH A 139
ILE A 137
VAL A  69
GLY A 122
LEU A 103
 None
 1.24A 3em0A-1bbuA:
0.0		 3em0A-1bbuA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		5 ILE A 492
ILE A 490
GLY A 440
VAL A 450
LEU A 466
 None
 1.28A 3em0A-1clwA:
2.9		 3em0A-1clwA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csy SYK PROTEIN TYROSINE
KINASE

(Homo sapiens) 		PF00017
(SH2) 		5 TYR A  91
ILE A  41
ILE A  65
GLY A  78
LEU A 102
 None
 1.00A 3em0A-1csyA:
0.9		 3em0A-1csyA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		5 ILE A 449
ILE A 424
VAL A 399
GLY A 395
VAL A  98
 None
 1.23A 3em0A-1d8cA:
1.4		 3em0A-1d8cA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 CYH A 139
ILE A 137
VAL A  69
GLY A 122
LEU A 103
 None
 1.26A 3em0A-1e1tA:
0.0		 3em0A-1e1tA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1faw HEMOGLOBIN (ALPHA
SUBUNIT)

(Anser anser) 		PF00042
(Globin) 		5 ILE A  73
ILE A  76
VAL A 135
GLY A 133
LEU A 125
 None
 1.20A 3em0A-1fawA:
0.0		 3em0A-1fawA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3

(Mus musculus) 		PF00025
(Arf) 		5 ILE A  87
ILE A  89
VAL A  91
GLY A  24
LEU A 116
 None
 1.10A 3em0A-1fzqA:
0.3		 3em0A-1fzqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ILE A 362
ILE A 358
VAL A 618
LYS A 621
LEU A 432
 None
 1.24A 3em0A-1jx2A:
0.0		 3em0A-1jx2A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ILE A 407
ILE A 409
VAL A 326
GLY A 329
LEU A 305
 None
 1.32A 3em0A-1n5xA:
0.0		 3em0A-1n5xA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 TYR C  28
ILE C  64
GLY C   6
VAL C  80
LEU C  52
 None
 1.28A 3em0A-1n8yC:
undetectable		 3em0A-1n8yC:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p99 HYPOTHETICAL PROTEIN
PG110

(Staphylococcus
aureus) 		PF03180
(Lipoprotein_9) 		5 ILE A 186
ILE A 142
GLY A 122
VAL A 201
LEU A 161
 None
 1.29A 3em0A-1p99A:
undetectable		 3em0A-1p99A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnr ENDO-1,4-B-D-MANNANA
SE

(Trichoderma
reesei) 		PF00150
(Cellulase) 		5 ILE A 180
VAL A 179
TYR A 144
VAL A 111
LEU A 235
 None
 1.19A 3em0A-1qnrA:
undetectable		 3em0A-1qnrA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Escherichia
coli) 		no annotation 5 ILE B 150
ILE B 149
VAL B 104
GLY B 100
LEU B 131
 None
 1.32A 3em0A-1r2kB:
undetectable		 3em0A-1r2kB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlf LAC REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		5 ILE A 123
ILE A 124
VAL A 136
VAL A 119
LEU A 307
 None
 1.24A 3em0A-1tlfA:
undetectable		 3em0A-1tlfA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		5 CYH C 662
ILE C 415
ILE C 661
VAL C 659
LEU C 664
 None
 1.23A 3em0A-1w36C:
undetectable		 3em0A-1w36C:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		5 ILE C 813
ILE C 818
VAL C 838
GLY C 787
LEU C 766
 None
 1.21A 3em0A-1wa5C:
undetectable		 3em0A-1wa5C:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Plasmodium
falciparum) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 CYH O 250
VAL O 172
GLY O 170
VAL O 220
LEU O 313
 None
 1.29A 3em0A-1ywgO:
undetectable		 3em0A-1ywgO:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE

(Streptococcus
pyogenes) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 ILE A  84
ILE A  83
VAL A  99
VAL A  58
LEU A 133
 None
 1.32A 3em0A-2ahrA:
undetectable		 3em0A-2ahrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2day RING FINGER PROTEIN
25

(Homo sapiens) 		PF05773
(RWD) 		5 ILE A  91
ILE A  94
LYS A 117
GLY A 118
VAL A  59
 None
 1.23A 3em0A-2dayA:
undetectable		 3em0A-2dayA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h39 PROBABLE
GALACTOSE-1-PHOSPHAT
E URIDYL TRANSFERASE

(Arabidopsis
thaliana) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		5 ILE A 145
ILE A 148
VAL A 127
GLY A 186
LEU A 278
 None
 1.29A 3em0A-2h39A:
undetectable		 3em0A-2h39A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iz7 MOCO CARRIER PROTEIN

(Chlamydomonas
reinhardtii) 		no annotation 5 ILE A 157
ILE A  33
LYS A  58
GLY A  56
VAL A 106
 None
 1.29A 3em0A-2iz7A:
undetectable		 3em0A-2iz7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjx URIDYLATE KINASE

(Bacillus
anthracis) 		PF00696
(AA_kinase) 		5 ILE A 129
ILE A 127
VAL A  40
VAL A  89
LEU A  11
 None
 1.17A 3em0A-2jjxA:
undetectable		 3em0A-2jjxA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lly NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4

(Homo sapiens) 		PF02932
(Neur_chan_memb) 		5 CYH A  18
ILE A  21
VAL A 120
GLY A 124
LEU A  14
 None
 1.15A 3em0A-2llyA:
undetectable		 3em0A-2llyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mkx AUTOLYSIN

(Enterococcus
faecalis) 		PF01476
(LysM) 		5 ILE A  39
VAL A   8
LYS A   9
GLY A  11
VAL A  25
 None
 1.27A 3em0A-2mkxA:
undetectable		 3em0A-2mkxA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 ILE A 249
VAL A 325
GLY A 377
VAL A 333
LEU A 363
 None
None
None
None
CSO  A 391 ( 4.4A)
 1.27A 3em0A-2o7qA:
undetectable		 3em0A-2o7qA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6c AQ_2013 PROTEIN

(Aquifex
aeolicus) 		PF01894
(UPF0047) 		5 ILE A 132
ILE A 134
VAL A  34
LYS A  35
GLY A 107
 None
 1.32A 3em0A-2p6cA:
undetectable		 3em0A-2p6cA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pth PEPTIDYL-TRNA
HYDROLASE

(Escherichia
coli) 		PF01195
(Pept_tRNA_hydro) 		5 ILE A   2
ILE A   5
VAL A  27
GLY A  23
VAL A  74
 None
 1.17A 3em0A-2pthA:
undetectable		 3em0A-2pthA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vza CELL FILAMENTATION
PROTEIN

(Bartonella
henselae) 		PF02661
(Fic) 		5 ILE A 276
ILE A 275
VAL A 270
LYS A 271
GLY A 272
 None
 1.23A 3em0A-2vzaA:
undetectable		 3em0A-2vzaA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A 158
ILE A 155
VAL A 129
GLY A 131
VAL A 309
 None
 1.30A 3em0A-2xf8A:
undetectable		 3em0A-2xf8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zt9 CYTOCHROME B6
CYTOCHROME B6-F
COMPLEX SUBUNIT 4
CYTOCHROME B6-F
COMPLEX SUBUNIT 8

(Nostoc sp. PCC
7120;
Nostoc sp. PCC
7120;
Nostoc sp. PCC
7120) 		PF00033
(Cytochrome_B)
PF00032
(Cytochrom_B_C)
PF03742
(PetN) 		5 ILE B  44
VAL A  42
GLY A  38
VAL H  22
LEU B  36
 None
None
HEM  A 303 ( 3.4A)
None
None
 1.11A 3em0A-2zt9B:
undetectable		 3em0A-2zt9B:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 5 ILE A 378
ILE A 379
VAL A 417
GLY A 406
LEU A 586
 None
 1.19A 3em0A-2zuxA:
1.5		 3em0A-2zuxA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 ILE A  80
ILE A  81
VAL A  64
GLY A  93
VAL A  12
 None
None
None
None
FNR  A 669 ( 4.3A)
 1.29A 3em0A-3b05A:
undetectable		 3em0A-3b05A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9j XANTHINE OXIDASE

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 ILE B 407
ILE B 409
VAL B 326
GLY B 329
LEU B 305
 None
 1.23A 3em0A-3b9jB:
1.4		 3em0A-3b9jB:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh6 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3

(Mus musculus) 		PF00025
(Arf) 		5 ILE A  87
ILE A  89
VAL A  91
GLY A  24
LEU A 116
 None
 1.13A 3em0A-3bh6A:
undetectable		 3em0A-3bh6A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8v PUTATIVE
ACETYLTRANSFERASE

(Desulfovibrio
alaskensis) 		no annotation 5 ILE A 469
ILE A 471
VAL A  54
GLY A  70
LEU A  63
 None
 1.27A 3em0A-3c8vA:
undetectable		 3em0A-3c8vA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A  23
ILE A  95
VAL A 138
GLY A 162
VAL A 127
 None
None
NAD  A 401 (-4.5A)
None
None
 1.21A 3em0A-3czmA:
undetectable		 3em0A-3czmA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e19 FEOA

(Thermococcus
thioreducens) 		PF04023
(FeoA) 		5 ILE A  53
ILE A  55
GLY A  35
VAL A  74
LEU A  68
 None
 1.18A 3em0A-3e19A:
undetectable		 3em0A-3e19A:
22.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		7 TYR A  14
CYH A  18
ILE A  21
ILE A  23
LYS A  30
GLY A  31
LEU A 123
 CHD  A 151 (-4.9A)
CHD  A 151 ( 4.2A)
CHD  A 153 ( 4.1A)
CHD  A 200 ( 4.7A)
CHD  A 152 ( 4.1A)
CHD  A 151 (-3.6A)
CHD  A 151 (-4.2A)
 1.05A 3em0A-3elzA:
24.6		 3em0A-3elzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		9 TYR A  14
CYH A  18
ILE A  21
ILE A  23
VAL A  27
GLY A  31
TYR A  53
VAL A  74
LEU A 123
 CHD  A 151 (-4.9A)
CHD  A 151 ( 4.2A)
CHD  A 153 ( 4.1A)
CHD  A 200 ( 4.7A)
CHD  A 152 ( 4.3A)
CHD  A 151 (-3.6A)
CHD  A 151 (-4.5A)
CHD  A 200 (-3.7A)
CHD  A 151 (-4.2A)
 0.59A 3em0A-3elzA:
24.6		 3em0A-3elzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvq FE(3+) IONS IMPORT
ATP-BINDING PROTEIN
FBPC

(Neisseria
gonorrhoeae) 		PF00005
(ABC_tran) 		5 ILE A   7
ILE A  61
GLY A  52
VAL A 193
LEU A  20
 None
 1.19A 3em0A-3fvqA:
undetectable		 3em0A-3fvqA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF01030
(Recep_L_domain) 		5 TYR A  28
ILE A  64
GLY A   6
VAL A  80
LEU A  52
 None
 1.24A 3em0A-3h3bA:
undetectable		 3em0A-3h3bA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 TYR B 984
ILE B 909
VAL B 988
GLY B 927
VAL B 904
 None
 1.29A 3em0A-3hkzB:
undetectable		 3em0A-3hkzB:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ILE A  93
VAL A 100
LYS A 122
GLY A 122
LEU A 324
 None
 1.29A 3em0A-3k2bA:
undetectable		 3em0A-3k2bA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		5 ILE A 251
ILE A 160
VAL A 159
GLY A 162
VAL A 182
 None
 1.17A 3em0A-3l6cA:
undetectable		 3em0A-3l6cA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Toxoplasma
gondii) 		PF01048
(PNP_UDP_1) 		5 ILE A  80
ILE A  26
VAL A  27
GLY A  95
LEU A 193
 None
None
PO4  A 281 ( 4.9A)
PO4  A 281 (-3.3A)
None
 1.30A 3em0A-3mb8A:
undetectable		 3em0A-3mb8A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmw ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		5 ILE A  41
ILE A  42
VAL A  50
GLY A  15
LEU A 307
 None
 1.30A 3em0A-3mmwA:
undetectable		 3em0A-3mmwA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oag RENIN

(Homo sapiens) 		PF00026
(Asp) 		5 ILE A 143
ILE A 147
VAL A 152
LYS A   4
VAL A  10
 None
 1.33A 3em0A-3oagA:
undetectable		 3em0A-3oagA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		5 ILE A 512
ILE A 508
VAL A 499
GLY A 461
LEU A 433
 None
 1.19A 3em0A-3ps5A:
undetectable		 3em0A-3ps5A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A   7
ILE A  55
VAL A  51
GLY A  99
LEU A  70
 None
 1.19A 3em0A-3sjnA:
undetectable		 3em0A-3sjnA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttl POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		5 TYR A 130
ILE A 291
VAL A 299
LYS A 302
VAL A  54
 None
 1.14A 3em0A-3ttlA:
undetectable		 3em0A-3ttlA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2i PEPTIDYL-TRNA
HYDROLASE

(Burkholderia
thailandensis) 		PF01195
(Pept_tRNA_hydro) 		5 ILE A   2
ILE A   5
VAL A  27
GLY A  23
VAL A  74
 None
 1.19A 3em0A-3v2iA:
undetectable		 3em0A-3v2iA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 CYH A 365
ILE A 366
ILE A 362
VAL A 108
GLY A 111
 OLC  A2005 (-3.5A)
None
OLC  A2005 ( 4.4A)
None
OLC  A2005 ( 4.6A)
 1.12A 3em0A-3vw7A:
undetectable		 3em0A-3vw7A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 CYH A 365
ILE A 366
VAL A 108
GLY A 111
LEU A 119
 OLC  A2005 (-3.5A)
None
None
OLC  A2005 ( 4.6A)
None
 1.23A 3em0A-3vw7A:
undetectable		 3em0A-3vw7A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF00150
(Cellulase) 		5 ILE A 180
VAL A 179
TYR A 144
VAL A 111
LEU A 235
 None
 1.16A 3em0A-3zizA:
undetectable		 3em0A-3zizA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		5 ILE A 290
ILE A 360
VAL A 386
LYS A 387
VAL A 341
 None
 1.20A 3em0A-4bf8A:
undetectable		 3em0A-4bf8A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		5 ILE A 530
ILE A 532
VAL A 504
GLY A 510
LEU A 463
 None
None
None
SO4  A1538 (-3.2A)
None
 1.12A 3em0A-4bqhA:
undetectable		 3em0A-4bqhA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7q RALF,
PROLINE/BETAINE
TRANSPORTER

(Legionella
pneumophila;
Rickettsia
prowazekii) 		PF01369
(Sec7) 		5 ILE A 316
ILE A 274
VAL A 276
GLY A 260
LEU A 298
 None
 1.13A 3em0A-4d7qA:
1.2		 3em0A-4d7qA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep5 CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUVC

(Thermus
thermophilus) 		PF02075
(RuvC) 		5 ILE A   6
ILE A 150
VAL A 110
GLY A 106
LEU A  88
 None
None
None
SO4  A 204 (-3.1A)
None
 1.27A 3em0A-4ep5A:
undetectable		 3em0A-4ep5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evz HISF-LUCA

(synthetic
construct) 		PF00977
(His_biosynth) 		5 TYR A 182
ILE A   6
LYS A 179
GLY A 203
VAL A  48
 None
None
None
PI  A 301 (-3.7A)
None
 1.27A 3em0A-4evzA:
undetectable		 3em0A-4evzA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo1 LINCOSAMIDE
RESISTANCE PROTEIN

(Staphylococcus
haemolyticus) 		PF10706
(Aminoglyc_resit) 		5 TYR A  68
ILE A  49
ILE A  47
VAL A   6
GLY A  87
 None
 1.26A 3em0A-4fo1A:
undetectable		 3em0A-4fo1A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		5 ILE A 487
VAL A 503
LYS A 625
GLY A 512
LEU A 479
 None
SLA  A 801 (-3.8A)
SLA  A 801 (-2.9A)
None
None
 1.29A 3em0A-4fwgA:
undetectable		 3em0A-4fwgA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF) 		5 ILE A 338
ILE A 411
VAL A 415
GLY A 417
LEU A 390
 None
 1.25A 3em0A-4fxqA:
undetectable		 3em0A-4fxqA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN

(Enterococcus
faecalis) 		PF00497
(SBP_bac_3) 		5 TYR A 106
ILE A 238
ILE A  48
GLY A  89
LEU A 226
 None
None
None
GLN  A 302 (-4.9A)
None
 1.20A 3em0A-4g4pA:
undetectable		 3em0A-4g4pA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hmy ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		PF00025
(Arf) 		5 ILE C  20
ILE C  89
VAL C  91
GLY C  24
LEU C 116
 None
 1.33A 3em0A-4hmyC:
undetectable		 3em0A-4hmyC:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 ILE A 511
ILE A 515
GLY A 521
TYR A 536
VAL A 547
 None
 1.17A 3em0A-4hozA:
1.8		 3em0A-4hozA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		5 ILE A 225
ILE A 223
VAL A 244
GLY A 246
TYR A 257
 None
 1.08A 3em0A-4j0wA:
2.4		 3em0A-4j0wA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5q O-ACETYL-ADP-RIBOSE
DEACETYLASE 1

(Homo sapiens) 		PF01661
(Macro) 		5 ILE A 120
VAL A  68
GLY A  66
VAL A 139
LEU A 127
 None
 1.26A 3em0A-4j5qA:
undetectable		 3em0A-4j5qA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 CYH A 284
ILE A 283
GLY A 228
VAL A 153
LEU A 407
 NK  A 501 (-3.7A)
NK  A 501 (-4.4A)
None
None
None
 1.32A 3em0A-4jz6A:
undetectable		 3em0A-4jz6A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ILE A  66
VAL A 135
GLY A 137
VAL A 154
LEU A  15
 None
 1.20A 3em0A-4k9qA:
undetectable		 3em0A-4k9qA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN

(Lactococcus
lactis) 		PF00497
(SBP_bac_3) 		5 TYR A 111
ILE A 243
ILE A  53
GLY A  94
LEU A 231
 None
None
None
MES  A 301 (-4.6A)
None
 1.26A 3em0A-4kptA:
undetectable		 3em0A-4kptA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kr5 GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN

(Lactococcus
lactis) 		PF00497
(SBP_bac_3) 		5 TYR A 343
ILE A 475
ILE A 285
GLY A 326
LEU A 463
 None
 1.30A 3em0A-4kr5A:
undetectable		 3em0A-4kr5A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvs ALDEHYDE
DECARBONYLASE

(Prochlorococcus
marinus) 		PF11266
(Ald_deCOase) 		5 TYR A  34
ILE A  40
LYS A  85
GLY A  84
LEU A 204
 None
 1.32A 3em0A-4kvsA:
undetectable		 3em0A-4kvsA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqz UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF16253
(DUF4909) 		5 ILE A  80
ILE A  83
VAL A  87
GLY A  59
LEU A 154
 None
 1.10A 3em0A-4lqzA:
4.7		 3em0A-4lqzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Caldanaerobacter
subterraneus) 		no annotation 5 ILE B 198
ILE B  38
GLY B  45
VAL B   5
LEU B  87
 None
None
SO4  B 301 (-3.4A)
None
None
 1.05A 3em0A-4mkiB:
undetectable		 3em0A-4mkiB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		5 TYR A 350
ILE A 481
ILE A 292
GLY A 333
LEU A 469
 None
None
None
ACT  A 507 (-4.7A)
None
 1.31A 3em0A-4oenA:
undetectable		 3em0A-4oenA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oki PHTHIOCEROL
SYNTHESIS POLYKETIDE
SYNTHASE TYPE I PPSC

(Mycobacterium
tuberculosis) 		PF00107
(ADH_zinc_N) 		5 ILE A 722
ILE A 700
GLY A 705
TYR A 679
LEU A 738
 None
 0.92A 3em0A-4okiA:
undetectable		 3em0A-4okiA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		5 CYH A  48
ILE A  46
VAL A 236
GLY A  27
LEU A  44
 None
 1.23A 3em0A-4otkA:
undetectable		 3em0A-4otkA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pia AUTOLYSIN E

(Staphylococcus
aureus) 		PF01832
(Glucosaminidase) 		5 ILE A 190
VAL A 116
LYS A 115
GLY A 114
LEU A 136
 None
None
None
CL  A 309 (-4.1A)
None
 1.31A 3em0A-4piaA:
undetectable		 3em0A-4piaA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq9 BETA-1,3-GLUCANASE

(Mycobacterium
marinum) 		PF00722
(Glyco_hydro_16) 		5 CYH A 185
ILE A 145
VAL A 208
GLY A 191
TYR A 223
 None
 1.20A 3em0A-4pq9A:
undetectable		 3em0A-4pq9A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qp0 ENDO-BETA-MANNANASE

(Rhizomucor
miehei) 		PF00150
(Cellulase) 		5 ILE A  93
ILE A  89
GLY A  85
VAL A  37
LEU A 156
 None
 1.10A 3em0A-4qp0A:
undetectable		 3em0A-4qp0A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rc6 ALDEHYDE
DECARBONYLASE

(Synechococcus
elongatus) 		PF11266
(Ald_deCOase) 		5 TYR B  21
ILE B  27
LYS B  72
GLY B  71
LEU B 191
 None
 1.30A 3em0A-4rc6B:
undetectable		 3em0A-4rc6B:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 CYH A 240
ILE A 239
ILE A 131
VAL A 166
GLY A 262
 None
 1.29A 3em0A-4zajA:
undetectable		 3em0A-4zajA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zef AMINO ACID ABC
TRANSPORTER AMINO
ACID-BINDING/PERMEAS
E

(Enterococcus
faecalis) 		PF00497
(SBP_bac_3) 		5 TYR A 343
ILE A 475
ILE A 285
GLY A 326
LEU A 463
 None
 1.25A 3em0A-4zefA:
undetectable		 3em0A-4zefA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgz ANTIZYME INHIBITOR 1

(Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 TYR A  66
ILE A  79
ILE A  48
GLY A 273
LEU A  77
 None
 1.22A 3em0A-4zgzA:
undetectable		 3em0A-4zgzA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7i GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC

(Mus musculus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 CYH O 201
ILE O 118
VAL O 136
GLY O 111
VAL O 125
 None
 1.19A 3em0A-5c7iO:
undetectable		 3em0A-5c7iO:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f42 ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Francisella
tularensis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 ILE A 194
ILE A 212
VAL A 242
LYS A 241
LEU A 219
 None
 1.13A 3em0A-5f42A:
undetectable		 3em0A-5f42A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcn OS09G0567300 PROTEIN

(Oryza sativa) 		PF07992
(Pyr_redox_2) 		5 ILE A  88
ILE A  37
GLY A  15
VAL A 327
LEU A  78
 None
None
FAD  A 500 (-3.2A)
None
None
 1.10A 3em0A-5jcnA:
undetectable		 3em0A-5jcnA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxx ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Moraxella
catarrhalis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 ILE A   3
ILE A   9
LYS A  29
GLY A  28
LEU A  39
 None
 1.17A 3em0A-5jxxA:
undetectable		 3em0A-5jxxA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kia L-THREONINE
3-DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A  81
ILE A  69
VAL A  85
GLY A  67
VAL A  23
 None
 1.27A 3em0A-5kiaA:
undetectable		 3em0A-5kiaA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kte DIVALENT METAL
CATION TRANSPORTER
MNTH

(Deinococcus
radiodurans) 		PF01566
(Nramp) 		5 ILE A 422
ILE A 423
VAL A 379
GLY A 223
TYR A  70
 None
 1.29A 3em0A-5kteA:
undetectable		 3em0A-5kteA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf7 PROTEASOME SUBUNIT
BETA TYPE-1

(Homo sapiens) 		PF00227
(Proteasome) 		5 ILE L  12
ILE L 109
VAL L 121
GLY L 112
VAL L 175
 None
 1.23A 3em0A-5lf7L:
undetectable		 3em0A-5lf7L:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		5 TYR A 114
ILE A 335
ILE A 338
VAL A 215
GLY A 188
 None
 1.31A 3em0A-5mifA:
undetectable		 3em0A-5mifA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n3u PHYCOCYANOBILIN
LYASE SUBUNIT BETA

(Nostoc sp. PCC
7120) 		no annotation 5 ILE B  71
ILE B  83
LYS B 116
GLY B 117
VAL B  64
 None
 1.22A 3em0A-5n3uB:
undetectable		 3em0A-5n3uB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 5 TYR C  28
ILE C  64
GLY C   6
VAL C  80
LEU C  52
 None
 1.31A 3em0A-5o4gC:
undetectable		 3em0A-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 ILE A 385
VAL A 369
GLY A 397
VAL A 433
LEU A 497
 None
 1.12A 3em0A-5u03A:
undetectable		 3em0A-5u03A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8o HOMOSERINE
O-ACETYLTRANSFERASE

(Mycolicibacterium
hassiacum) 		PF00561
(Abhydrolase_1) 		5 ILE A 168
VAL A 153
GLY A 155
VAL A 131
LEU A 331
 None
 1.29A 3em0A-5w8oA:
undetectable		 3em0A-5w8oA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 5 CYH A 289
ILE A 288
GLY A 302
VAL A 315
LEU A 320
 None
 1.16A 3em0A-5wdxA:
undetectable		 3em0A-5wdxA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avy ACYL-PROTEIN
THIOESTERASE 2

(Zea mays) 		no annotation 5 ILE A  60
ILE A  35
VAL A 122
GLY A 124
LEU A  55
 None
 1.27A 3em0A-6avyA:
undetectable		 3em0A-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 5 ILE A 624
ILE A 571
VAL A 561
GLY A 569
LEU A 626
 None
 1.24A 3em0A-6bdzA:
undetectable		 3em0A-6bdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 ILE A  23
VAL A  58
LYS A  57
GLY A  56
LEU A 226
 None
 1.26A 3em0A-6ci9A:
undetectable		 3em0A-6ci9A:
undetectable