SIMILAR PATTERNS OF AMINO ACIDS FOR 3ELZ_C_CHDC153

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcb 5-FORMYLTETRAHYDROFO
LATE CYCLO-LIGASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF01812
(5-FTHF_cyc-lig) 		4 ILE A  12
THR A 181
LYS A 183
TYR A 129
 None
 1.02A 3elzC-2jcbA:
0.0		 3elzC-2jcbA:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		4 ILE A  21
THR A  73
LYS A  77
TYR A  97
 CHD  A 153 ( 4.1A)
CHD  A 200 (-3.1A)
CHD  A 153 ( 4.6A)
CHD  A 153 (-4.2A)
 0.93A 3elzC-3elzA:
24.4		 3elzC-3elzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Enterococcus
faecium) 		PF01636
(APH) 		4 ILE A 199
THR A  32
LYS A  42
TYR A  87
 None
 1.30A 3elzC-3hamA:
0.4		 3elzC-3hamA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmm IRON-REGULATED CELL
WALL-ANCHORED
PROTEIN

(Staphylococcus
aureus) 		no annotation 4 ILE E 298
THR E 317
LYS E 318
TYR E 310
 None
 1.30A 3elzC-5vmmE:
1.6		 3elzC-5vmmE:
19.14