SIMILAR PATTERNS OF AMINO ACIDS FOR 3ELZ_C_CHDC151_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csy SYK PROTEIN TYROSINE
KINASE

(Homo sapiens) 		PF00017
(SH2) 		5 TYR A  91
ILE A  41
ILE A  65
GLY A  78
LEU A 102
 None
 1.07A 3elzC-1csyA:
0.0		 3elzC-1csyA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		5 ILE A 449
ILE A 424
VAL A 399
GLY A 395
VAL A  98
 None
 1.19A 3elzC-1d8cA:
0.0		 3elzC-1d8cA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dts DETHIOBIOTIN
SYNTHETASE

(Escherichia
coli) 		PF13500
(AAA_26) 		5 ILE A 219
ILE A 203
GLY A 146
VAL A   6
LEU A 199
 None
 1.23A 3elzC-1dtsA:
0.0		 3elzC-1dtsA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exf EXFOLIATVE TOXIN A

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		5 ILE A 238
ILE A 231
VAL A 210
GLY A 198
PRO A  26
 None
 1.20A 3elzC-1exfA:
0.0		 3elzC-1exfA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krt LYSYL-TRNA
SYNTHETASE (PRODUCT
OF LYSS GENE)

(Escherichia
coli) 		PF01336
(tRNA_anti-codon) 		5 ILE A 138
ILE A  95
GLY A  92
LEU A 122
ARG A  73
 None
 1.13A 3elzC-1krtA:
0.0		 3elzC-1krtA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5h FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01913
(FTR)
PF02741
(FTR_C) 		5 ILE A  56
ILE A  74
VAL A  23
GLY A 107
PRO A  66
 None
 1.17A 3elzC-1m5hA:
0.0		 3elzC-1m5hA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 TYR C  28
ILE C  64
GLY C   6
VAL C  80
LEU C  52
 None
 1.20A 3elzC-1n8yC:
0.0		 3elzC-1n8yC:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8a PROTEIN TYROSINE
PHOSPHATASE

(Tritrichomonas
suis) 		PF01451
(LMWPc) 		5 ILE A  94
ILE A  90
GLY A  13
PRO A  19
ARG A  70
 None
 1.25A 3elzC-1p8aA:
0.0		 3elzC-1p8aA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phj TELOMERE-BINDING
PROTEIN BETA SUBUNIT

(Sterkiella nova) 		PF07404
(TEBP_beta) 		5 ILE B 215
ILE B 218
VAL B  68
PRO B 123
VAL B  43
 None
 1.29A 3elzC-1phjB:
0.0		 3elzC-1phjB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfz HYPOTHETICAL PROTEIN
APC35681

(Geobacillus
stearothermophilus) 		PF04608
(PgpA) 		5 ILE A 126
ILE A  27
VAL A  51
TYR A 116
LEU A 142
 None
 1.23A 3elzC-1rfzA:
undetectable		 3elzC-1rfzA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ILE B  38
ILE B  75
VAL B  59
PRO B 110
LEU B  64
 None
 1.27A 3elzC-1skyB:
undetectable		 3elzC-1skyB:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni) 		PF13580
(SIS_2) 		5 ILE A  47
ILE A  45
GLY A  32
TYR A  68
LEU A 143
 None
 1.16A 3elzC-1tk9A:
undetectable		 3elzC-1tk9A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up4 6-PHOSPHO-BETA-GLUCO
SIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 ILE A  76
GLY A 160
TYR A 155
VAL A 127
LEU A 305
 None
 1.16A 3elzC-1up4A:
undetectable		 3elzC-1up4A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A  34
GLY A  81
TYR A  78
VAL A 140
LEU A 150
 None
 1.27A 3elzC-1uufA:
undetectable		 3elzC-1uufA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu8 HYPOTHETICAL PROTEIN
PH0463

(Pyrococcus
horikoshii) 		PF01887
(SAM_adeno_trans) 		5 ILE A 152
ILE A  78
GLY A  92
PRO A  97
VAL A 103
 None
 1.20A 3elzC-1wu8A:
undetectable		 3elzC-1wu8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN

(Listeria
monocytogenes) 		PF04608
(PgpA) 		5 ILE A 127
ILE A  28
VAL A  52
TYR A 117
LEU A 143
 None
 1.29A 3elzC-1y9iA:
undetectable		 3elzC-1y9iA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		5 ILE A 344
ILE A 332
GLY A 580
TYR A 743
PRO A 740
 None
 0.90A 3elzC-1z26A:
undetectable		 3elzC-1z26A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
furiosus) 		PF01470
(Peptidase_C15) 		5 ILE A 200
ILE A  65
GLY A   7
TYR A 189
PRO A  18
 None
 1.27A 3elzC-1z8wA:
undetectable		 3elzC-1z8wA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF10433
(MMS1_N) 		5 ILE A 471
ILE A 469
VAL A 463
VAL A 426
ARG A 639
 None
 1.25A 3elzC-2b5nA:
undetectable		 3elzC-2b5nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ILE A 319
ILE A 351
VAL A 245
PRO A 218
LEU A 399
 None
 1.05A 3elzC-2bvgA:
undetectable		 3elzC-2bvgA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cf5 CINNAMYL ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A  41
GLY A 133
VAL A 146
LEU A  29
ARG A  30
 None
 1.27A 3elzC-2cf5A:
undetectable		 3elzC-2cf5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g39 ACETYL-COA HYDROLASE

(Pseudomonas
aeruginosa) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ILE A 204
ILE A 130
GLY A  35
PRO A  87
VAL A 114
 None
None
None
None
ACY  A 903 ( 4.8A)
 1.07A 3elzC-2g39A:
undetectable		 3elzC-2g39A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g39 ACETYL-COA HYDROLASE

(Pseudomonas
aeruginosa) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ILE A 352
ILE A 354
VAL A 271
GLY A 274
LEU A 283
 None
 1.17A 3elzC-2g39A:
undetectable		 3elzC-2g39A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		5 ILE A  94
ILE A  80
VAL A  83
GLY A 245
LEU A  62
 None
 1.28A 3elzC-2go4A:
undetectable		 3elzC-2go4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 265
ILE A 412
GLY A 352
PRO A 340
LEU A 246
 None
 1.19A 3elzC-2gp6A:
undetectable		 3elzC-2gp6A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hp3 IDS-EPIMERASE

(Agrobacterium
tumefaciens) 		PF03972
(MmgE_PrpD) 		5 VAL A 127
GLY A 129
PRO A 100
VAL A  95
LEU A   6
 None
 1.29A 3elzC-2hp3A:
undetectable		 3elzC-2hp3A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ic7 MALTOSE
TRANSACETYLASE

(Geobacillus
kaustophilus) 		PF00132
(Hexapep)
PF12464
(Mac)
PF14602
(Hexapep_2) 		5 ILE A 103
VAL A 107
GLY A  87
VAL A  95
LEU A  50
 None
 1.28A 3elzC-2ic7A:
undetectable		 3elzC-2ic7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		5 ILE A  98
VAL A 256
PRO A  53
VAL A 248
LEU A 412
 None
 1.28A 3elzC-2n0sA:
undetectable		 3elzC-2n0sA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oum 50S RIBOSOMAL
PROTEIN L1

(Thermus
thermophilus) 		PF00687
(Ribosomal_L1) 		5 ILE A 224
ILE A  22
PRO A  65
VAL A 175
LEU A 209
 None
 1.20A 3elzC-2oumA:
undetectable		 3elzC-2oumA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcu CARBOXYPEPTIDASE A4

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 ILE A 255
GLY A 252
TYR A 248
VAL A 247
ARG A 127
 None
None
None
None
ZN  A 999 (-4.5A)
 0.97A 3elzC-2pcuA:
undetectable		 3elzC-2pcuA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pku PRKCA-BINDING
PROTEIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 ILE A  35
ILE A  90
VAL A  93
GLY A  95
VAL A  23
 None
 1.29A 3elzC-2pkuA:
undetectable		 3elzC-2pkuA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvb HALOALKANE
DEHALOGENASE 3

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		5 ILE A  49
ILE A 283
VAL A 269
GLY A 271
LEU A  45
 None
 1.24A 3elzC-2qvbA:
undetectable		 3elzC-2qvbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A 177
ILE A 178
GLY A 181
PRO A 126
LEU A 195
 None
 1.26A 3elzC-2vdcA:
2.0		 3elzC-2vdcA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		5 ILE A 476
ILE A 477
VAL A  47
GLY A  52
TYR A  58
 None
 1.03A 3elzC-2wsxA:
undetectable		 3elzC-2wsxA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		5 ILE A 363
ILE A 366
VAL A 293
GLY A 291
TYR A 316
 None
 1.09A 3elzC-2xsgA:
1.7		 3elzC-2xsgA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbv UNCHARACTERIZED
CONSERVED PROTEIN

(Thermotoga
maritima) 		PF01887
(SAM_adeno_trans) 		5 ILE A   2
ILE A  22
VAL A  21
VAL A  66
LEU A 139
 None
None
None
ADN  A 501 (-4.9A)
None
 1.22A 3elzC-2zbvA:
undetectable		 3elzC-2zbvA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zt9 CYTOCHROME B6
CYTOCHROME B6-F
COMPLEX SUBUNIT 4
CYTOCHROME B6-F
COMPLEX SUBUNIT 8

(Nostoc sp. PCC
7120;
Nostoc sp. PCC
7120;
Nostoc sp. PCC
7120) 		PF00033
(Cytochrome_B)
PF00032
(Cytochrom_B_C)
PF03742
(PetN) 		5 ILE B  44
VAL A  42
GLY A  38
VAL H  22
LEU B  36
 None
None
HEM  A 303 ( 3.4A)
None
None
 1.10A 3elzC-2zt9B:
undetectable		 3elzC-2zt9B:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ILE A 126
ILE A  77
GLY A  70
PRO A 171
LEU A 157
 None
 1.20A 3elzC-3a9vA:
undetectable		 3elzC-3a9vA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agf GLUTAMINASE 1

(Bacillus
subtilis) 		PF04960
(Glutaminase) 		5 ILE A 220
ILE A 235
VAL A 239
PRO A 123
LEU A 278
 None
 1.23A 3elzC-3agfA:
undetectable		 3elzC-3agfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		5 TYR A  75
ILE A 289
ILE A 292
VAL A 174
GLY A 148
 None
 1.29A 3elzC-3ailA:
undetectable		 3elzC-3ailA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1

(Saccharomyces
cerevisiae) 		PF03556
(Cullin_binding)
PF14555
(UBA_4) 		5 ILE A 149
GLY A 138
PRO A  72
VAL A  78
LEU A 115
 None
 1.16A 3elzC-3bq3A:
undetectable		 3elzC-3bq3A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A  23
ILE A  95
VAL A 138
GLY A 162
VAL A 127
 None
None
NAD  A 401 (-4.5A)
None
None
 1.20A 3elzC-3czmA:
undetectable		 3elzC-3czmA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		5 ILE A  10
ILE A  31
GLY A 385
TYR A 376
LEU A 390
 None
 1.26A 3elzC-3dc8A:
undetectable		 3elzC-3dc8A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		5 TYR C  63
ILE C  24
ILE C  27
VAL C 159
LEU C  73
 None
 1.13A 3elzC-3degC:
undetectable		 3elzC-3degC:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ILE B 292
ILE B 284
VAL B 252
GLY B 248
LEU B 272
 None
None
MPD  B 501 ( 4.7A)
None
None
 1.10A 3elzC-3dm9B:
undetectable		 3elzC-3dm9B:
18.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		5 ILE A  23
TYR A  53
VAL A  74
LEU A 123
ARG A 125
 CHD  A 200 ( 4.7A)
CHD  A 151 (-4.5A)
CHD  A 200 (-3.7A)
CHD  A 151 (-4.2A)
CHD  A 151 (-4.1A)
 1.18A 3elzC-3elzA:
21.6		 3elzC-3elzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		10 TYR A  14
ILE A  21
ILE A  23
VAL A  27
GLY A  31
TYR A  53
PRO A  54
VAL A  74
LEU A 123
ARG A 125
 CHD  A 151 (-4.9A)
CHD  A 153 ( 4.1A)
CHD  A 200 ( 4.7A)
CHD  A 152 ( 4.3A)
CHD  A 151 (-3.6A)
CHD  A 151 (-4.5A)
None
CHD  A 200 (-3.7A)
CHD  A 151 (-4.2A)
CHD  A 151 (-4.1A)
 0.54A 3elzC-3elzA:
21.6		 3elzC-3elzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvq FE(3+) IONS IMPORT
ATP-BINDING PROTEIN
FBPC

(Neisseria
gonorrhoeae) 		PF00005
(ABC_tran) 		5 ILE A   7
ILE A  61
GLY A  52
VAL A 193
LEU A  20
 None
 1.23A 3elzC-3fvqA:
undetectable		 3elzC-3fvqA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3giu PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Staphylococcus
aureus) 		PF01470
(Peptidase_C15) 		5 ILE A  30
ILE A   3
VAL A  62
GLY A 162
LEU A 191
 None
 1.14A 3elzC-3giuA:
undetectable		 3elzC-3giuA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 ILE A 324
ILE A 464
VAL A 495
GLY A 497
ARG A 499
 None
 1.19A 3elzC-3gmeA:
1.6		 3elzC-3gmeA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A1427
ILE A1369
VAL A1383
GLY A1069
PRO A1439
 None
 0.96A 3elzC-3greA:
3.3		 3elzC-3greA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF01030
(Recep_L_domain) 		5 TYR A  28
ILE A  64
GLY A   6
VAL A  80
LEU A  52
 None
 1.19A 3elzC-3h3bA:
undetectable		 3elzC-3h3bA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmw ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		5 ILE A  41
ILE A  42
VAL A  50
GLY A  15
LEU A 307
 None
 1.28A 3elzC-3mmwA:
undetectable		 3elzC-3mmwA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0p SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		5 ILE A 180
ILE A 122
GLY A 125
PRO A  85
LEU A 143
 None
 1.19A 3elzC-3o0pA:
undetectable		 3elzC-3o0pA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prh TRYPTOPHANYL-TRNA
SYNTHETASE

(Bacillus
subtilis) 		PF00579
(tRNA-synt_1b) 		5 ILE A 284
VAL A  15
GLY A  18
VAL A  28
LEU A 249
 None
 1.28A 3elzC-3prhA:
undetectable		 3elzC-3prhA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 ILE A 836
ILE A 844
GLY A 812
TYR A 769
LEU A 799
 None
 1.28A 3elzC-3psiA:
undetectable		 3elzC-3psiA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pw9 UPF0603 PROTEIN
AT1G54780,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04536
(TPM_phosphatase) 		5 ILE A  89
VAL A 168
GLY A 177
VAL A 106
LEU A 138
 None
 1.17A 3elzC-3pw9A:
undetectable		 3elzC-3pw9A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri) 		PF01979
(Amidohydro_1) 		5 ILE A 308
ILE A 249
VAL A 237
PRO A 289
LEU A 304
 None
 1.18A 3elzC-3sfwA:
undetectable		 3elzC-3sfwA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A   7
ILE A  55
VAL A  51
GLY A  99
LEU A  70
 None
 1.08A 3elzC-3sjnA:
undetectable		 3elzC-3sjnA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t43 HIV EPITOPE-SCAFFOLD
4E10_1XIZA_S0_006_C

(synthetic
construct) 		PF00359
(PTS_EIIA_2) 		5 ILE A 127
VAL A 151
GLY A  65
VAL A 109
LEU A 120
 None
 1.20A 3elzC-3t43A:
undetectable		 3elzC-3t43A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9i MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Roseiflexus sp.
RS-1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 295
ILE A 292
GLY A 285
PRO A  95
ARG A  88
 None
 1.27A 3elzC-3u9iA:
undetectable		 3elzC-3u9iA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 ILE A  24
ILE A  42
VAL A  95
GLY A 193
ARG A   7
 None
 1.09A 3elzC-3vm5A:
undetectable		 3elzC-3vm5A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0f ENDONUCLEASE 8-LIKE
3

(Mus musculus) 		PF06831
(H2TH) 		5 TYR A  74
ILE A 105
ILE A  14
GLY A  76
LEU A 124
 None
IOD  A 305 ( 4.3A)
None
IOD  A 302 (-3.4A)
None
 1.25A 3elzC-3w0fA:
undetectable		 3elzC-3w0fA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE

(Mycolicibacterium
smegmatis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		5 ILE A 196
GLY A 140
PRO A 387
VAL A 182
LEU A 105
 None
FAD  A 600 ( 4.8A)
None
None
None
 1.26A 3elzC-4autA:
undetectable		 3elzC-4autA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg5 BBA65

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		5 ILE A 120
ILE A 123
GLY A 126
TYR A  90
LEU A  58
 None
 1.17A 3elzC-4bg5A:
undetectable		 3elzC-4bg5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		5 ILE A 530
ILE A 532
VAL A 504
GLY A 510
LEU A 463
 None
None
None
SO4  A1538 (-3.2A)
None
 1.16A 3elzC-4bqhA:
undetectable		 3elzC-4bqhA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ILE A  97
ILE A 166
VAL A 170
GLY A 172
TYR A   3
 None
 1.02A 3elzC-4cokA:
undetectable		 3elzC-4cokA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 ILE K 269
ILE K 271
VAL K 274
PRO K 215
VAL K 223
 None
 1.15A 3elzC-4cr4K:
undetectable		 3elzC-4cr4K:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ILE A  82
ILE A 107
GLY A 343
PRO A 276
LEU A  27
 None
 0.98A 3elzC-4dpkA:
undetectable		 3elzC-4dpkA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 ILE A 511
ILE A 515
GLY A 521
TYR A 536
VAL A 547
 None
 1.16A 3elzC-4hozA:
2.3		 3elzC-4hozA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m62 T117

(synthetic
construct) 		PF00359
(PTS_EIIA_2) 		5 ILE S 151
VAL S  19
GLY S  89
VAL S 133
LEU S 144
 None
 1.05A 3elzC-4m62S:
undetectable		 3elzC-4m62S:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Proteus
mirabilis) 		PF02028
(BCCT) 		5 ILE A 476
ILE A 477
VAL A  47
GLY A  52
TYR A  58
 None
 1.01A 3elzC-4m8jA:
undetectable		 3elzC-4m8jA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgg MUCONATE LACTONIZING
ENZYME

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 291
ILE A 304
VAL A 300
VAL A 269
LEU A 125
 None
 1.10A 3elzC-4mggA:
undetectable		 3elzC-4mggA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Mesorhizobium
japonicum) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ILE A   2
ILE A 164
VAL A 150
LEU A  21
ARG A  20
 None
 1.09A 3elzC-4om8A:
undetectable		 3elzC-4om8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onu ACETYLTRANSFERASE
PAT

(Mycolicibacterium
smegmatis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		5 ILE A 218
VAL A 217
GLY A 215
PRO A 142
VAL A 145
 None
 1.12A 3elzC-4onuA:
undetectable		 3elzC-4onuA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Chitinophaga
pinensis) 		PF00561
(Abhydrolase_1) 		5 ILE A 219
ILE A 127
VAL A 103
GLY A 105
LEU A 242
 None
 1.15A 3elzC-4pw0A:
undetectable		 3elzC-4pw0A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql0 FILAMENTOUS
HEMAGGLUTININ
TRANSPORTER PROTEIN
FHAC

(Bordetella
pertussis) 		PF03865
(ShlB)
PF08479
(POTRA_2)
PF17287
(POTRA_3) 		5 TYR A 452
ILE A 506
VAL A 493
GLY A 510
PRO A 536
 None
 1.20A 3elzC-4ql0A:
2.2		 3elzC-4ql0A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1v D-3-PHOSPHOGLYCERATE
DEHYDROGENASE-RELATE
D PROTEIN

(Vibrio cholerae) 		no annotation 5 ILE D 172
ILE D 151
GLY D 155
PRO D 102
LEU D 187
 None
 0.99A 3elzC-4s1vD:
undetectable		 3elzC-4s1vD:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 ILE A 237
GLY A 217
TYR A  47
VAL A  59
LEU A 231
 None
 1.13A 3elzC-4uzuA:
2.2		 3elzC-4uzuA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wdr HALOALKANE
DEHALOGENASE

(Sphingobium
japonicum) 		PF00561
(Abhydrolase_1) 		5 ILE A  48
ILE A 282
VAL A 268
GLY A 270
LEU A  44
 None
 1.24A 3elzC-4wdrA:
undetectable		 3elzC-4wdrA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wp8 MA1120

(Mycobacterium
avium) 		PF00211
(Guanylate_cyc) 		5 ILE A 146
ILE A 144
VAL A 142
GLY A 106
VAL A  92
 None
 1.17A 3elzC-4wp8A:
undetectable		 3elzC-4wp8A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgz ANTIZYME INHIBITOR 1

(Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 TYR A  66
ILE A  79
ILE A  48
GLY A 273
LEU A  77
 None
 1.21A 3elzC-4zgzA:
undetectable		 3elzC-4zgzA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 ILE A 161
ILE A 183
VAL A  67
GLY A  69
LEU A 169
 None
 1.28A 3elzC-5dotA:
undetectable		 3elzC-5dotA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ILE C 134
VAL C 374
GLY C 371
VAL C 450
LEU C 157
 None
 1.12A 3elzC-5fseC:
undetectable		 3elzC-5fseC:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 ILE A 453
VAL A 456
GLY A 458
TYR A 105
ARG A  87
 None
 1.16A 3elzC-5fv4A:
undetectable		 3elzC-5fv4A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hnz PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL,PLUS-E
ND DIRECTED
KINESIN-1/KINESIN-14
,PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL

(Drosophila
melanogaster;
Rattus
norvegicus) 		PF00225
(Kinesin) 		5 ILE K 124
ILE K 127
VAL K  86
GLY K  95
VAL K 315
 None
 1.12A 3elzC-5hnzK:
undetectable		 3elzC-5hnzK:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilb PROTEASE DO-LIKE 2,
CHLOROPLASTIC,PROTEA
SE DO-LIKE 9

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 ILE A 259
VAL A 298
GLY A 256
LEU A 216
ARG A 386
 None
 1.26A 3elzC-5ilbA:
undetectable		 3elzC-5ilbA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcn OS09G0567300 PROTEIN

(Oryza sativa) 		PF07992
(Pyr_redox_2) 		5 ILE A  88
ILE A  37
GLY A  15
VAL A 327
LEU A  78
 None
None
FAD  A 500 (-3.2A)
None
None
 1.02A 3elzC-5jcnA:
undetectable		 3elzC-5jcnA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		5 ILE A 237
ILE A 230
VAL A 227
TYR A  83
ARG A 280
 None
GOL  A 609 ( 4.8A)
None
None
None
 1.26A 3elzC-5m10A:
undetectable		 3elzC-5m10A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		5 TYR A 114
ILE A 335
ILE A 338
VAL A 215
GLY A 188
 None
 1.27A 3elzC-5mifA:
undetectable		 3elzC-5mifA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 5 TYR C  28
ILE C  64
GLY C   6
VAL C  80
LEU C  52
 None
 1.21A 3elzC-5o4gC:
undetectable		 3elzC-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o82 INTRACELLULAR
EXO-ALPHA-(1->5)-L-A
RABINOFURANOSIDASE

(Chaetomium
thermophilum) 		no annotation 5 ILE A 121
VAL A 105
GLY A  82
VAL A 159
LEU A 138
 None
 1.16A 3elzC-5o82A:
1.6		 3elzC-5o82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 ILE A 385
VAL A 369
GLY A 397
VAL A 433
LEU A 497
 None
 1.24A 3elzC-5u03A:
undetectable		 3elzC-5u03A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufv GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN

(Thermothelomyces
thermophila) 		PF03443
(Glyco_hydro_61) 		5 ILE A 204
GLY A 195
VAL A  38
LEU A  81
ARG A 154
 None
 1.25A 3elzC-5ufvA:
undetectable		 3elzC-5ufvA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfh SALT STRESS-INDUCED
PROTEIN

(Oryza sativa) 		no annotation 5 ILE A 136
ILE A  40
VAL A  29
TYR A 142
PRO A  23
 None
 1.23A 3elzC-5xfhA:
undetectable		 3elzC-5xfhA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a31 PEPTIDYL-TRNA
HYDROLASE

(Acinetobacter
baumannii) 		no annotation 5 ILE A   4
ILE A   7
VAL A  29
GLY A  25
VAL A  76
 None
 1.17A 3elzC-6a31A:
undetectable		 3elzC-6a31A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4

(Xenopus
tropicalis) 		no annotation 5 TYR A 342
ILE A 381
VAL A 325
VAL A 429
LEU A 388
 None
 1.28A 3elzC-6bbjA:
undetectable		 3elzC-6bbjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 5 ILE A 624
ILE A 571
VAL A 561
GLY A 569
LEU A 626
 None
 1.26A 3elzC-6bdzA:
undetectable		 3elzC-6bdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8g TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4

(Xenopus
tropicalis) 		no annotation 5 TYR A 342
ILE A 381
VAL A 325
VAL A 429
LEU A 388
 None
 1.29A 3elzC-6c8gA:
undetectable		 3elzC-6c8gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en9 HYDROGENASE-2 SMALL
CHAIN

(Escherichia
coli) 		no annotation 5 ILE S 104
ILE S  84
VAL S 137
GLY S 124
VAL S 148
 None
 1.04A 3elzC-6en9S:
undetectable		 3elzC-6en9S:
undetectable