SIMILAR PATTERNS OF AMINO ACIDS FOR 3ELZ_C_CHDC150_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 ASN A 135
PHE A 184
VAL A 171
LEU A 141
THR A 142
 None
 1.37A 3elzC-1ciyA:
0.0		 3elzC-1ciyA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5y ROB TRANSCRIPTION
FACTOR

(Escherichia
coli) 		PF06445
(GyrI-like)
PF12833
(HTH_18) 		5 THR A 184
VAL A 196
LEU A 284
ILE A 285
TYR A 244
 None
 1.34A 3elzC-1d5yA:
0.0		 3elzC-1d5yA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME

(Escherichia
coli) 		PF00994
(MoCF_biosynth) 		5 THR A  76
VAL A  70
LEU A  61
ILE A 129
THR A  57
 SO4  A 201 (-2.8A)
None
None
None
None
 1.47A 3elzC-1di6A:
undetectable		 3elzC-1di6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pisum sativum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ASN A   7
THR A  32
VAL A 111
ILE A 126
THR A 136
 None
 1.41A 3elzC-1dxlA:
undetectable		 3elzC-1dxlA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 PHE A 200
VAL A  79
LEU A  74
ILE A  65
THR A  71
 None
 1.38A 3elzC-1h1cA:
undetectable		 3elzC-1h1cA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 ASN A 418
THR A 450
VAL A 383
LEU A 442
TYR A 522
 None
 1.16A 3elzC-1j0hA:
0.0		 3elzC-1j0hA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV

(Griffonia
simplicifolia) 		PF00139
(Lectin_legB) 		5 PHE A  78
VAL A 187
LEU A 199
TYR A 191
THR A 159
 None
 1.30A 3elzC-1ledA:
0.9		 3elzC-1ledA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf9 PHENAZINE
BIOSYNTHESIS PROTEIN
PHZD

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		5 THR A 202
VAL A 205
LEU A 157
ILE A 177
THR A 160
 None
 1.18A 3elzC-1nf9A:
undetectable		 3elzC-1nf9A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 ASN E 145
VAL E 119
LEU E 115
ILE E 120
THR E 113
 None
 0.99A 3elzC-1nfiE:
undetectable		 3elzC-1nfiE:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1u GASTROTROPIN

(Homo sapiens) 		PF14651
(Lipocalin_7) 		5 TRP A  49
GLN A  51
VAL A  83
LEU A  90
TYR A  97
 None
 0.88A 3elzC-1o1uA:
14.2		 3elzC-1o1uA:
56.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1u GASTROTROPIN

(Homo sapiens) 		PF14651
(Lipocalin_7) 		5 TRP A  49
GLN A  51
VAL A  83
TYR A  97
GLN A  99
 None
 1.22A 3elzC-1o1uA:
14.2		 3elzC-1o1uA:
56.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		5 THR A  40
VAL A   7
LEU A  18
ILE A  10
TYR A  55
 NDP  A1501 ( 4.1A)
None
None
None
None
 1.46A 3elzC-1rpnA:
undetectable		 3elzC-1rpnA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svv THREONINE ALDOLASE

(Leishmania
major) 		PF01212
(Beta_elim_lyase) 		5 ASN A 153
THR A 155
LEU A 206
ILE A 169
THR A 207
 None
 1.44A 3elzC-1svvA:
undetectable		 3elzC-1svvA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		5 THR A 324
VAL A 289
LEU A 283
TYR A 419
THR A 334
 None
 1.18A 3elzC-1ua4A:
undetectable		 3elzC-1ua4A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		5 ASN A  45
VAL A 127
LEU A 129
TYR A 279
GLN A 211
 None
 1.43A 3elzC-1uz4A:
undetectable		 3elzC-1uz4A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 VAL A 215
PHE A 280
LEU A 433
ILE A 431
GLN A 435
 None
 1.37A 3elzC-2bg9A:
undetectable		 3elzC-2bg9A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 THR A 379
VAL A 241
LEU A 296
ILE A 245
THR A 299
 None
 1.41A 3elzC-2cjqA:
undetectable		 3elzC-2cjqA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		5 THR A  38
VAL A  41
VAL A  82
ILE A  22
TYR A  51
 None
 1.46A 3elzC-2d1cA:
undetectable		 3elzC-2d1cA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2

(Homo sapiens) 		PF00179
(UQ_con) 		5 THR A 142
VAL A 120
LEU A 119
ILE A 123
TYR A 134
 None
 1.39A 3elzC-2espA:
undetectable		 3elzC-2espA:
24.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f73 FATTY ACID-BINDING
PROTEIN, LIVER

(Homo sapiens) 		PF14651
(Lipocalin_7) 		5 ASN A  61
THR A  73
VAL A  83
LEU A  91
THR A 102
 None
 0.77A 3elzC-2f73A:
14.8		 3elzC-2f73A:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnw NON-SYMBIOTIC
HEMOGLOBIN 1

(Oryza sativa) 		PF00042
(Globin) 		5 PHE A  54
VAL A 121
LEU A 125
ILE A  43
THR A 128
 HEM  A 166 (-3.9A)
HEM  A 166 (-4.4A)
None
None
None
 1.44A 3elzC-2gnwA:
undetectable		 3elzC-2gnwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwg 4-OXALOMESACONATE
HYDRATASE

(Rhodopseudomonas
palustris) 		PF04909
(Amidohydro_2) 		5 GLN A 264
THR A 303
VAL A 276
ILE A 321
TYR A 322
 None
 1.23A 3elzC-2gwgA:
undetectable		 3elzC-2gwgA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ka0 UNCHARACTERIZED
PROTEIN TM1367

(Thermotoga
maritima) 		PF04126
(Cyclophil_like) 		5 THR A  47
VAL A  49
PHE A  45
VAL A  13
ILE A  14
 None
 1.23A 3elzC-2ka0A:
undetectable		 3elzC-2ka0A:
25.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lba BABP PROTEIN

(Gallus gallus) 		PF14651
(Lipocalin_7) 		7 TRP A  49
GLN A  51
ASN A  61
THR A  73
PHE A  79
VAL A  83
TYR A  97
 CHO  A 201 (-2.9A)
CHO  A 201 ( 3.4A)
CHO  A 201 ( 3.5A)
CHO  A 201 (-2.8A)
CHO  A 201 (-3.5A)
CHO  A 201 ( 4.0A)
CHO  A 201 (-2.6A)
 1.02A 3elzC-2lbaA:
17.6		 3elzC-2lbaA:
60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mna SINGLE-STRANDED DNA
BINDING PROTEIN
(SSB)

(Sulfolobus
solfataricus) 		PF01336
(tRNA_anti-codon) 		5 GLN A  82
VAL A  44
LEU A  53
ILE A  43
THR A  54
 None
 1.38A 3elzC-2mnaA:
undetectable		 3elzC-2mnaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nbh FUNGAL HYDROPHOBIN

(Schizophyllum
commune) 		PF01185
(Hydrophobin) 		5 ASN A 106
THR A  97
LEU A  57
ILE A  63
THR A  54
 None
 1.32A 3elzC-2nbhA:
undetectable		 3elzC-2nbhA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 THR A 407
VAL A 333
LEU A 359
ILE A 328
TYR A 355
 None
None
None
DHK  A4733 (-3.9A)
None
 1.42A 3elzC-2o7qA:
undetectable		 3elzC-2o7qA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obn HYPOTHETICAL PROTEIN

(Trichormus
variabilis) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		5 THR A 111
VAL A  77
ILE A  78
TYR A  91
THR A  24
 None
 1.36A 3elzC-2obnA:
undetectable		 3elzC-2obnA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 VAL A 320
ILE A 169
TYR A 344
GLN A 342
THR A 339
 None
 1.10A 3elzC-2r9vA:
undetectable		 3elzC-2r9vA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ASN A 242
VAL A 277
LEU A 338
ILE A 340
THR A 211
 None
None
None
BEZ  A1529 ( 4.9A)
None
 1.27A 3elzC-2v7bA:
undetectable		 3elzC-2v7bA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vou 2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE

(Paenarthrobacter
nicotinovorans) 		PF00070
(Pyr_redox) 		5 PHE A 383
ILE A 204
TYR A 206
GLN A 222
THR A 171
 None
GOL  A1396 ( 4.4A)
GOL  A1396 (-4.8A)
GOL  A1396 ( 2.8A)
FAD  A1395 ( 4.7A)
 1.30A 3elzC-2vouA:
undetectable		 3elzC-2vouA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Thermotoga
maritima) 		PF00467
(KOW)
PF02357
(NusG) 		5 VAL A 342
PHE A 232
VAL A  39
LEU A 283
ILE A 277
 None
 1.26A 3elzC-2xhcA:
undetectable		 3elzC-2xhcA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 VAL A 725
VAL A 545
LEU A 599
ILE A 549
TYR A 586
 None
 1.38A 3elzC-2xt6A:
undetectable		 3elzC-2xt6A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Thermus
thermophilus) 		PF00753
(Lactamase_B) 		5 ASN A 199
THR A 292
PHE A 276
VAL A 196
LEU A 193
 None
 1.42A 3elzC-2zo4A:
undetectable		 3elzC-2zo4A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acp WD REPEAT-CONTAINING
PROTEIN YGL004C

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ASN A 330
VAL A  32
VAL A 347
LEU A 312
ILE A 355
 None
 1.20A 3elzC-3acpA:
2.3		 3elzC-3acpA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acp WD REPEAT-CONTAINING
PROTEIN YGL004C

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 VAL A  46
PHE A  61
VAL A 379
ILE A  10
GLN A  11
 None
 1.38A 3elzC-3acpA:
2.3		 3elzC-3acpA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azc CYTOCHROME B6-F
COMPLEX IRON-SULFUR
SUBUNIT

(Thermosynechococcus
elongatus) 		PF00355
(Rieske) 		5 THR A  89
PHE A 163
ILE A  99
TYR A  69
THR A  94
 None
 1.41A 3elzC-3azcA:
undetectable		 3elzC-3azcA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do5 HOMOSERINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 THR A 254
VAL A 273
PHE A 245
ILE A 237
THR A 235
 None
 1.30A 3elzC-3do5A:
undetectable		 3elzC-3do5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtn PUTATIVE
METHYLTRANSFERASE
MM_2633

(Methanosarcina
mazei) 		PF13649
(Methyltransf_25) 		5 VAL A 207
LEU A 147
ILE A 117
TYR A 129
GLN A 195
 None
 1.36A 3elzC-3dtnA:
undetectable		 3elzC-3dtnA:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		11 TRP A  49
GLN A  51
ASN A  61
THR A  73
PHE A  79
VAL A  83
LEU A  90
ILE A  92
TYR A  97
GLN A  99
THR A 101
 CHD  A 150 (-3.5A)
CHD  A 150 ( 3.7A)
CHD  A 150 ( 4.0A)
CHD  A 200 (-3.1A)
CHD  A 153 ( 4.9A)
CHD  A 150 (-4.4A)
CHD  A 150 (-4.4A)
CHD  A 150 (-3.9A)
CHD  A 153 (-4.2A)
CHD  A 150 (-3.3A)
CHD  A 150 (-2.9A)
 0.54A 3elzC-3elzA:
24.4		 3elzC-3elzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		11 TRP A  49
GLN A  51
ASN A  61
THR A  73
VAL A  74
VAL A  83
LEU A  90
ILE A  92
TYR A  97
GLN A  99
THR A 101
 CHD  A 150 (-3.5A)
CHD  A 150 ( 3.7A)
CHD  A 150 ( 4.0A)
CHD  A 200 (-3.1A)
CHD  A 200 (-3.7A)
CHD  A 150 (-4.4A)
CHD  A 150 (-4.4A)
CHD  A 150 (-3.9A)
CHD  A 153 (-4.2A)
CHD  A 150 (-3.3A)
CHD  A 150 (-2.9A)
 0.53A 3elzC-3elzA:
24.4		 3elzC-3elzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		5 VAL A  59
VAL A  83
ILE A  92
GLN A  99
THR A 101
 None
CHD  A 150 (-4.4A)
CHD  A 150 (-3.9A)
CHD  A 150 (-3.3A)
CHD  A 150 (-2.9A)
 1.11A 3elzC-3elzA:
24.4		 3elzC-3elzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger) 		PF06441
(EHN) 		5 TRP A  60
PHE A 375
VAL A 298
LEU A 274
ILE A 277
 None
 1.44A 3elzC-3g0iA:
undetectable		 3elzC-3g0iA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h05 UNCHARACTERIZED
PROTEIN VPA0413

(Vibrio
parahaemolyticus) 		PF01467
(CTP_transf_like) 		5 VAL A  55
VAL A  83
LEU A  76
ILE A  37
GLN A  74
 None
 1.42A 3elzC-3h05A:
undetectable		 3elzC-3h05A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		5 GLN A 168
THR A 180
VAL A 181
ILE A 152
TYR A 177
 CO  A 245 ( 2.7A)
None
None
None
None
 1.38A 3elzC-3h7jA:
undetectable		 3elzC-3h7jA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		5 LEU A  87
ILE A  85
TYR A  69
GLN A  89
THR A  88
 None
 1.44A 3elzC-3i7aA:
undetectable		 3elzC-3i7aA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izk CHAPERONIN

(Methanococcus
maripaludis) 		PF00118
(Cpn60_TCP1) 		5 ASN A 419
THR A  32
VAL A  29
VAL A 447
LEU A 445
 None
 1.12A 3elzC-3izkA:
undetectable		 3elzC-3izkA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd4 PUTATIVE PROTEASE

(Parabacteroides
distasonis) 		PF12969
(DUF3857)
PF12970
(DUF3858) 		5 THR A 354
VAL A 355
VAL A 376
ILE A 384
THR A 368
 None
 1.33A 3elzC-3kd4A:
undetectable		 3elzC-3kd4A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kop UNCHARACTERIZED
PROTEIN

(Arthrobacter
sp. FB24) 		PF12903
(DUF3830) 		5 ASN A   6
THR A   8
VAL A 137
LEU A  19
ILE A 136
 None
 1.46A 3elzC-3kopA:
undetectable		 3elzC-3kopA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldh LACTATE
DEHYDROGENASE

(Squalus
acanthias) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLN A 314
VAL A 285
LEU A 322
ILE A 281
THR A 321
 None
 1.33A 3elzC-3ldhA:
undetectable		 3elzC-3ldhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncy ADIC

(Salmonella
enterica) 		PF13520
(AA_permease_2) 		5 ASN A  34
THR A  38
VAL A 240
ILE A  43
THR A  49
 None
 1.42A 3elzC-3ncyA:
undetectable		 3elzC-3ncyA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pam TRANSMEMBRANE
PROTEIN

(Bartonella
henselae) 		PF00496
(SBP_bac_5) 		5 THR A 362
VAL A 397
LEU A 394
ILE A 562
TYR A 365
 None
 1.41A 3elzC-3pamA:
undetectable		 3elzC-3pamA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		5 GLN B 305
THR B 301
VAL B 302
LEU B 418
ILE B 420
 None
 1.12A 3elzC-3q75B:
undetectable		 3elzC-3q75B:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk9 MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM44

(Saccharomyces
cerevisiae) 		PF04280
(Tim44) 		5 VAL A 364
PHE A 289
VAL A 298
LEU A 302
ILE A 297
 None
 1.35A 3elzC-3qk9A:
undetectable		 3elzC-3qk9A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt2 INTERLEUKIN-5
RECEPTOR SUBUNIT
ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		5 THR A  68
VAL A  67
PHE A  74
VAL A  78
THR A  59
 None
 1.32A 3elzC-3qt2A:
undetectable		 3elzC-3qt2A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 THR A  60
VAL A 129
LEU A 127
ILE A 142
TYR A 155
 None
 1.34A 3elzC-3wfaA:
2.2		 3elzC-3wfaA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 VAL A 725
VAL A 545
LEU A 599
ILE A 549
TYR A 586
 None
 1.40A 3elzC-3zhrA:
undetectable		 3elzC-3zhrA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		5 THR A 128
VAL A 127
VAL A 183
ILE A 173
THR A 196
 None
 1.25A 3elzC-3zs6A:
undetectable		 3elzC-3zs6A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		5 GLN X 240
THR X 302
VAL X 220
LEU X 275
ILE X 211
 None
 1.35A 3elzC-3zyyX:
undetectable		 3elzC-3zyyX:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 THR A 344
VAL A 325
LEU A 295
ILE A 324
THR A 291
 None
 1.38A 3elzC-4a0sA:
undetectable		 3elzC-4a0sA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		5 THR A 174
VAL A 163
PHE A 166
VAL A 203
ILE A 152
 None
 1.46A 3elzC-4aoaA:
undetectable		 3elzC-4aoaA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arv PHYTASE

(Yersinia
kristensenii) 		PF00328
(His_Phos_2) 		5 PHE A 223
VAL A  33
LEU A  29
GLN A  26
THR A  27
 None
 1.37A 3elzC-4arvA:
undetectable		 3elzC-4arvA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE

(Mycolicibacterium
smegmatis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		5 THR A 129
VAL A 128
VAL A  97
LEU A 117
ILE A 196
 FAD  A 600 (-2.9A)
FAD  A 600 (-3.6A)
None
None
None
 1.18A 3elzC-4autA:
undetectable		 3elzC-4autA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boo ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 VAL A 215
PHE A 280
LEU A 433
ILE A 431
GLN A 435
 None
 1.38A 3elzC-4booA:
undetectable		 3elzC-4booA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		5 GLN I 240
THR I 302
VAL I 220
LEU I 275
ILE I 211
 None
 1.35A 3elzC-4c1nI:
undetectable		 3elzC-4c1nI:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ees PHOTOTROPIN-2

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		5 THR A 453
VAL A 454
VAL A 475
ILE A 486
THR A 394
 None
None
None
None
FMN  A1001 (-3.3A)
 1.37A 3elzC-4eesA:
undetectable		 3elzC-4eesA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gax AMORPHA-4,11-DIENE
SYNTHASE

(Artemisia annua) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 VAL A 517
PHE A 525
VAL A 295
LEU A 404
ILE A 292
 None
 1.27A 3elzC-4gaxA:
undetectable		 3elzC-4gaxA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h63 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 11
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		no annotation
PF10156
(Med17) 		5 GLN K 107
ASN Q 390
THR Q 282
LEU Q 398
ILE Q 310
 None
 1.43A 3elzC-4h63K:
undetectable		 3elzC-4h63K:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hte NICKING ENZYME

(Staphylococcus
aureus) 		no annotation 5 ASN A 362
THR A 281
VAL A 280
LEU A 255
GLN A 332
 None
 1.42A 3elzC-4hteA:
undetectable		 3elzC-4hteA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4

(Schizosaccharomyces
pombe) 		PF00179
(UQ_con) 		5 THR C 142
VAL C 120
LEU C 119
ILE C 123
TYR C 134
 None
 1.36A 3elzC-4ii2C:
1.8		 3elzC-4ii2C:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		5 THR A 145
VAL A 148
PHE A 141
VAL A  84
TYR A  80
 None
 1.24A 3elzC-4jhiA:
3.2		 3elzC-4jhiA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw5 OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		5 THR A 122
VAL A 121
VAL A  90
LEU A 110
ILE A 189
 FAD  A 501 (-2.9A)
FAD  A 501 (-3.7A)
None
None
None
 1.16A 3elzC-4kw5A:
undetectable		 3elzC-4kw5A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4liy FIBER PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		5 ASN A 192
THR A 270
VAL A 271
VAL A 189
LEU A 183
 None
 1.38A 3elzC-4liyA:
undetectable		 3elzC-4liyA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE

(Mycobacterium
tuberculosis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 VAL A 265
VAL A 122
LEU A  98
ILE A 121
GLN A 104
 None
NAP  A 301 (-4.3A)
None
None
None
 1.45A 3elzC-4ol9A:
undetectable		 3elzC-4ol9A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 5 THR A 413
VAL A 414
VAL A 399
ILE A 395
TYR A 391
 None
 1.25A 3elzC-4qnlA:
undetectable		 3elzC-4qnlA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlq BENZOATE-COENZYME A
LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ASN A 232
VAL A 271
LEU A 332
ILE A 334
THR A 201
 None
 1.35A 3elzC-4rlqA:
undetectable		 3elzC-4rlqA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA

(Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N) 		5 THR A 123
VAL A 109
VAL A  85
ILE A  84
THR A 118
 None
 1.45A 3elzC-4rltA:
undetectable		 3elzC-4rltA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnl POSSIBLE GALACTOSE
MUTAROTASE

(Streptomyces
platensis) 		PF01263
(Aldose_epim) 		5 GLN A  56
PHE A  10
ILE A  41
TYR A  67
THR A 180
 None
 1.25A 3elzC-4rnlA:
1.4		 3elzC-4rnlA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 5 VAL A 376
VAL A 383
LEU A 393
ILE A 359
THR A 366
 None
 1.28A 3elzC-4tz5A:
undetectable		 3elzC-4tz5A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 ASN A 135
PHE A 184
VAL A 171
LEU A 141
THR A 142
 None
 1.42A 3elzC-4w8jA:
undetectable		 3elzC-4w8jA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpr HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA

(Mus musculus) 		PF00989
(PAS)
PF08447
(PAS_3) 		5 ASN B 339
VAL B 336
PHE B 252
LEU B 262
ILE B 259
 None
 1.43A 3elzC-4zprB:
undetectable		 3elzC-4zprB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztp LIGHT CHAIN OF FAB
FRAGMENT OF RABBIT
MONOCLONAL ANTIBODY
R53

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLN L 184
THR L 131
VAL L 130
ILE L 158
GLN L 154
 None
 1.42A 3elzC-4ztpL:
undetectable		 3elzC-4ztpL:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 THR A 638
PHE A 552
LEU A 646
ILE A 525
GLN A 676
 None
 1.28A 3elzC-5a22A:
undetectable		 3elzC-5a22A:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dsc FAB HOU24.B LIGHT
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLN B 184
THR B 131
VAL B 130
ILE B 158
GLN B 154
 None
 1.43A 3elzC-5dscB:
undetectable		 3elzC-5dscB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 TRP B 648
VAL B 604
VAL B 735
LEU B 766
THR B 763
 None
 1.39A 3elzC-5eduB:
undetectable		 3elzC-5eduB:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsg MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HANTAVIRUS
NUCLEOPROTEIN

(Hantaan
orthohantavirus) 		PF00846
(Hanta_nucleocap)
PF13416
(SBP_bac_8) 		5 GLN A 375
THR A 369
ILE A 381
TYR A 362
GLN A 378
 None
 1.29A 3elzC-5fsgA:
undetectable		 3elzC-5fsgA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		5 VAL A 175
VAL A 229
ILE A 214
GLN A 264
THR A 267
 None
 1.45A 3elzC-5fyaA:
undetectable		 3elzC-5fyaA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		5 ASN A 440
THR A 225
VAL A 340
ILE A 339
THR A 299
 None
None
None
HEM  A 501 (-4.3A)
None
 1.02A 3elzC-5gweA:
undetectable		 3elzC-5gweA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipn RNA POLYMERASE SIGMA
FACTOR RPOS

(Escherichia
coli) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		5 GLN F 161
THR F 153
VAL F 172
LEU F 167
ILE F 169
 None
 1.20A 3elzC-5ipnF:
undetectable		 3elzC-5ipnF:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		5 GLN A 338
THR A 492
PHE A 179
VAL A 197
LEU A 329
 None
 1.32A 3elzC-5jlcA:
undetectable		 3elzC-5jlcA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 5 THR A 538
VAL A 537
LEU A 149
ILE A 147
THR A 152
 None
 1.46A 3elzC-5m6gA:
undetectable		 3elzC-5m6gA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sz8 HEMOLYSIN

(Proteus
mirabilis) 		PF05860
(Haemagg_act) 		5 ASN A  66
VAL A 135
PHE A  80
VAL A  43
ILE A  32
 None
 1.45A 3elzC-5sz8A:
undetectable		 3elzC-5sz8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 ASN A 151
VAL A 261
VAL A 181
LEU A 175
THR A 172
 None
FAD  A2001 (-4.5A)
None
None
None
 1.38A 3elzC-5ux5A:
undetectable		 3elzC-5ux5A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1a MYOSIN HEAVY CHAIN,
MUSCLE

(Drosophila
melanogaster) 		no annotation 5 GLN A 276
THR A 234
VAL A 235
ILE A 477
GLN A 474
 None
 1.26A 3elzC-5w1aA:
undetectable		 3elzC-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa0 PUTATIVE SULFITE
OXIDASE

(Sinorhizobium
meliloti) 		no annotation 5 VAL A 236
VAL A 200
ILE A 262
GLN A 263
THR A 258
 None
 1.32A 3elzC-5wa0A:
undetectable		 3elzC-5wa0A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES

(Corynebacterium
glutamicum) 		PF01053
(Cys_Met_Meta_PP) 		5 TRP A 148
THR A 126
VAL A 127
LEU A  89
THR A  86
 None
 1.18A 3elzC-5x5hA:
undetectable		 3elzC-5x5hA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7k LIPASE B

(Serratia
marcescens) 		no annotation 5 GLN A 413
THR A 373
VAL A 521
LEU A 522
ILE A 363
 None
 1.32A 3elzC-5x7kA:
undetectable		 3elzC-5x7kA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		5 ASN A 413
THR A 198
VAL A 313
ILE A 312
THR A 272
 None
None
None
HEM  A 502 (-3.7A)
None
 1.00A 3elzC-5xjnA:
undetectable		 3elzC-5xjnA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 THR A 379
VAL A 241
LEU A 296
ILE A 245
THR A 299
 None
 1.42A 3elzC-5y6rA:
undetectable		 3elzC-5y6rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 5 THR A  33
ILE A 120
TYR A  90
GLN A  16
THR A 458
 None
 1.42A 3elzC-5z0uA:
2.6		 3elzC-5z0uA:
undetectable