SIMILAR PATTERNS OF AMINO ACIDS FOR 3ELZ_B_CHDB152_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0p SITE-SPECIFIC
RECOMBINASE XERD

(Escherichia
coli) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		3 ASN A 256
HIS A 253
VAL A 118
 None
 0.88A 3elzB-1a0pA:
0.0		 3elzB-1a0pA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT

(Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 ASN A 140
HIS A 141
VAL A 148
 None
None
F43  A1553 (-3.6A)
 0.85A 3elzB-1e6vA:
0.0		 3elzB-1e6vA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 ASN A1151
HIS A1152
VAL A1159
 None
None
F43  A2570 (-3.7A)
 0.90A 3elzB-1e6yA:
undetectable		 3elzB-1e6yA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		3 ASN A 263
HIS A 264
VAL A  25
 None
 0.87A 3elzB-1f1xA:
0.0		 3elzB-1f1xA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Leishmania
mexicana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 ASN A  81
HIS A  83
VAL A  33
 None
 0.47A 3elzB-1gyqA:
0.0		 3elzB-1gyqA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 ASN A 137
HIS A 138
VAL A 145
 None
None
F43  A 700 (-3.5A)
 0.88A 3elzB-1mroA:
0.0		 3elzB-1mroA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus;
Bos taurus) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 ASN A 158
HIS C 445
VAL A  75
 None
 0.77A 3elzB-1o7dA:
0.0		 3elzB-1o7dA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE

(Escherichia
coli) 		PF00218
(IGPS)
PF00697
(PRAI) 		3 ASN A 313
HIS A 314
VAL A 319
 None
 0.86A 3elzB-1piiA:
0.0		 3elzB-1piiA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxz MAJOR POLLEN
ALLERGEN JUN A 1

(Juniperus ashei) 		PF00544
(Pec_lyase_C) 		3 ASN A 194
HIS A 195
VAL A 198
 None
 0.78A 3elzB-1pxzA:
undetectable		 3elzB-1pxzA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qy9 HYPOTHETICAL PROTEIN
YDDE

(Escherichia
coli) 		PF02567
(PhzC-PhzF) 		3 ASN A 247
HIS A 244
VAL A 237
 None
 0.83A 3elzB-1qy9A:
undetectable		 3elzB-1qy9A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0i YLR011WP

(Saccharomyces
cerevisiae) 		PF03358
(FMN_red) 		3 ASN A 174
HIS A 173
VAL A 153
 None
 0.85A 3elzB-1t0iA:
undetectable		 3elzB-1t0iA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uar RHODANESE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		3 ASN A 103
HIS A 105
VAL A  82
 None
 0.84A 3elzB-1uarA:
undetectable		 3elzB-1uarA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47) 		PF00544
(Pec_lyase_C) 		3 ASN A 250
HIS A 251
VAL A 254
 None
 0.83A 3elzB-1vblA:
undetectable		 3elzB-1vblA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wad CYTOCHROME C3

(Desulfovibrio
gigas) 		PF02085
(Cytochrom_CIII) 		3 ASN A  25
HIS A  26
VAL A   3
 HEM  A 114 (-3.9A)
HEM  A 117 (-3.2A)
HEM  A 117 ( 4.7A)
 0.84A 3elzB-1wadA:
undetectable		 3elzB-1wadA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		3 ASN A 404
HIS A 403
VAL A 332
 None
 0.91A 3elzB-1x3lA:
undetectable		 3elzB-1x3lA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		3 ASN X 452
HIS X 453
VAL X 484
 None
 0.60A 3elzB-1z3iX:
undetectable		 3elzB-1z3iX:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 ASN A  77
HIS A  75
VAL A  56
 None
 0.90A 3elzB-1zfjA:
undetectable		 3elzB-1zfjA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzh CYTOCHROME C
PEROXIDASE

(Rhodobacter
capsulatus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 ASN A  82
HIS A 264
VAL A 219
 CA  A 401 (-3.0A)
ZN  A 402 ( 3.6A)
HEC  A 803 (-3.9A)
 0.89A 3elzB-1zzhA:
undetectable		 3elzB-1zzhA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4g HYPOTHETICAL PROTEIN
BSU11850

(Bacillus
subtilis) 		PF13563
(2_5_RNA_ligase2) 		3 ASN A  57
HIS A  54
VAL A 103
 None
 0.88A 3elzB-2d4gA:
undetectable		 3elzB-2d4gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exn HYPOTHETICAL PROTEIN
BOR11

(Bordetella
bronchiseptica) 		PF03476
(MOSC_N) 		3 ASN A 106
HIS A 107
VAL A  48
 None
 0.77A 3elzB-2exnA:
undetectable		 3elzB-2exnA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmc DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		3 ASN A 281
HIS A 279
VAL A 261
 None
 0.71A 3elzB-2hmcA:
undetectable		 3elzB-2hmcA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2z HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01933
(UPF0052) 		3 ASN A 302
HIS A 301
VAL A 218
 None
NAD  A 400 (-3.6A)
NAD  A 400 (-4.4A)
 0.85A 3elzB-2o2zA:
undetectable		 3elzB-2o2zA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p87 PRE-MRNA-SPLICING
FACTOR PRP8

(Caenorhabditis
elegans) 		PF01398
(JAB)
PF08084
(PROCT) 		3 ASN A2275
HIS A2302
VAL A2271
 None
 0.88A 3elzB-2p87A:
undetectable		 3elzB-2p87A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		3 ASN A 303
HIS A 302
VAL A 217
 None
 0.76A 3elzB-2ppvA:
undetectable		 3elzB-2ppvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqr PUTATIVE SULFATASE

(Rhizobium
leguminosarum) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 ASN A  72
HIS A  73
VAL A  76
 None
 0.58A 3elzB-2vqrA:
2.9		 3elzB-2vqrA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w07 MINOR PILIN SUBUNIT
PAPF

(Escherichia
coli) 		PF00419
(Fimbrial) 		3 ASN B  31
HIS B  34
VAL B  35
 None
 0.90A 3elzB-2w07B:
undetectable		 3elzB-2w07B:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 ASN A  72
HIS A  73
VAL A  76
 None
 0.61A 3elzB-2w8sA:
undetectable		 3elzB-2w8sA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yl2 ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ASN A 603
HIS A 541
VAL A 542
 None
 0.88A 3elzB-2yl2A:
0.9		 3elzB-2yl2A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zom PROTEIN CUTA,
CHLOROPLAST,
PUTATIVE, EXPRESSED

(Oryza sativa) 		PF03091
(CutA1) 		3 ASN A  82
HIS A  83
VAL A  17
 GOL  A 115 (-3.3A)
None
None
 0.81A 3elzB-2zomA:
undetectable		 3elzB-2zomA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cav 3-OXO-5-BETA-STEROID
4-DEHYDROGENASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		3 ASN A  92
HIS A  93
VAL A 121
 None
 0.89A 3elzB-3cavA:
undetectable		 3elzB-3cavA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1p PUTATIVE THIOSULFATE
SULFURTRANSFERASE
YOR285W

(Saccharomyces
cerevisiae) 		PF00581
(Rhodanese) 		3 ASN A  62
HIS A  56
VAL A  55
 None
 0.85A 3elzB-3d1pA:
undetectable		 3elzB-3d1pA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e81 ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		3 ASN A  45
HIS A  44
VAL A  50
 None
EDO  A 168 (-3.9A)
None
 0.90A 3elzB-3e81A:
undetectable		 3elzB-3e81A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN

(Homo sapiens) 		PF08324
(PUL) 		3 ASN A 697
HIS A 699
VAL A 736
 None
 0.67A 3elzB-3ebbA:
undetectable		 3elzB-3ebbA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		3 ASN A 263
HIS A 264
VAL A  25
 None
 0.88A 3elzB-3eckA:
undetectable		 3elzB-3eckA:
16.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		3 ASN A  55
HIS A  57
VAL A  74
 None
CHD  A 152 (-3.7A)
CHD  A 200 (-3.7A)
 0.42A 3elzB-3elzA:
24.8		 3elzB-3elzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
innocua) 		PF06838
(Met_gamma_lyase) 		3 ASN A  48
HIS A  46
VAL A  42
 None
 0.84A 3elzB-3fd0A:
undetectable		 3elzB-3fd0A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq9 CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 ASN A 101
HIS A 283
VAL A 238
 CA  A 402 (-2.9A)
HEM  A 401 (-3.7A)
HEM  A 401 (-3.8A)
 0.86A 3elzB-3hq9A:
undetectable		 3elzB-3hq9A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Candida
albicans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ASN A 343
HIS A 342
VAL A 322
 None
 0.85A 3elzB-3hskA:
undetectable		 3elzB-3hskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		3 ASN A 409
HIS A 410
VAL A 309
 None
 0.80A 3elzB-3iu1A:
undetectable		 3elzB-3iu1A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu INTEGRIN-LINKED
KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ASN A 279
HIS A 282
VAL A 390
 None
 0.82A 3elzB-3kmuA:
undetectable		 3elzB-3kmuA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		3 ASN A 100
HIS A  98
VAL A  56
 None
 0.86A 3elzB-3m8uA:
undetectable		 3elzB-3m8uA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3may POSSIBLE EXPORTED
PROTEIN

(Mycobacterium
tuberculosis) 		PF16525
(MHB) 		3 ASN A  67
HIS A  63
VAL A  96
 None
 0.85A 3elzB-3mayA:
undetectable		 3elzB-3mayA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus) 		PF00073
(Rhv) 		3 ASN B  51
HIS B  49
VAL B  48
 None
 0.84A 3elzB-3napB:
undetectable		 3elzB-3napB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3v PHOSPHOGLYCERATE
KINASE

(Campylobacter
jejuni) 		PF00162
(PGK) 		3 ASN A 127
HIS A 154
VAL A 149
 None
None
SO4  A 404 (-4.3A)
 0.89A 3elzB-3q3vA:
undetectable		 3elzB-3q3vA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd7 UNCHARACTERIZED
PROTEIN YDAL

(Escherichia
coli) 		PF01713
(Smr) 		3 ASN X 132
HIS X 130
VAL X  95
 None
 0.90A 3elzB-3qd7X:
undetectable		 3elzB-3qd7X:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE

(Mesorhizobium
loti) 		PF13561
(adh_short_C2) 		3 ASN A 198
HIS A 197
VAL A  92
 None
4PL  A 252 (-3.6A)
NAD  A 251 (-4.8A)
 0.82A 3elzB-3rwbA:
undetectable		 3elzB-3rwbA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 ASN X 293
HIS X 447
VAL X 446
 ACT  X1428 (-3.7A)
None
None
 0.71A 3elzB-3rwkX:
undetectable		 3elzB-3rwkX:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT

(uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 ASN A 145
HIS A 146
VAL A 153
 None
None
M43  A1001 (-3.5A)
 0.84A 3elzB-3sqgA:
undetectable		 3elzB-3sqgA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t36 ENDO-TYPE
MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A

(Escherichia
coli) 		PF01464
(SLT) 		3 ASN A 183
HIS A 184
VAL A 144
 None
 0.82A 3elzB-3t36A:
undetectable		 3elzB-3t36A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9l 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		3 ASN A  94
HIS A  93
VAL A 125
 None
 0.88A 3elzB-3u9lA:
undetectable		 3elzB-3u9lA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vns NRPS ADENYLATION
PROTEIN CYTC1

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ASN A 479
HIS A 480
VAL A 437
 None
 0.78A 3elzB-3vnsA:
undetectable		 3elzB-3vnsA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aal CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 ASN A 101
HIS A 283
VAL A 238
 CA  A 425 (-2.9A)
HEC  A 424 (-3.5A)
HEC  A 424 (-4.0A)
 0.88A 3elzB-4aalA:
undetectable		 3elzB-4aalA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blq P4

(Pseudomonas
phage phi8) 		PF11602
(NTPase_P4) 		3 ASN A 121
HIS A 122
VAL A 273
 None
 0.90A 3elzB-4blqA:
undetectable		 3elzB-4blqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Neurospora
crassa) 		no annotation 3 ASN A 597
HIS A 598
VAL A 582
 None
 0.77A 3elzB-4bwkA:
undetectable		 3elzB-4bwkA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS) 		3 ASN A 400
HIS A 401
VAL A 336
 None
 0.90A 3elzB-4c1nA:
undetectable		 3elzB-4c1nA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Neurospora
crassa) 		no annotation 3 ASN B 597
HIS B 598
VAL B 582
 None
 0.81A 3elzB-4czxB:
undetectable		 3elzB-4czxB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica) 		PF00291
(PALP) 		3 ASN A  79
HIS A  80
VAL A 158
 LLP  A  51 (-3.6A)
LLP  A  51 (-4.8A)
None
 0.65A 3elzB-4d8uA:
undetectable		 3elzB-4d8uA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e54 DNA DAMAGE-BINDING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		3 ASN B 292
HIS B 247
VAL B 248
 None
 0.87A 3elzB-4e54B:
undetectable		 3elzB-4e54B:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ioy FACT COMPLEX SUBUNIT
SPT16

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		3 ASN X 726
HIS X 741
VAL X 758
 None
 0.91A 3elzB-4ioyX:
1.5		 3elzB-4ioyX:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE

(Caenorhabditis
elegans) 		PF00481
(PP2C) 		3 ASN A 116
HIS A  66
VAL A  65
 None
 0.86A 3elzB-4jndA:
1.3		 3elzB-4jndA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf9 HEMIN DEGRADING
FACTOR

(Pseudomonas
aeruginosa) 		PF05171
(HemS) 		3 ASN A 291
HIS A  84
VAL A 258
 None
 0.81A 3elzB-4mf9A:
undetectable		 3elzB-4mf9A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk2 HEMOGLOBIN-LIKE
PROTEIN

(Methylacidiphilum
infernorum) 		PF01152
(Bac_globin) 		3 ASN A  73
HIS A  71
VAL A  94
 None
 0.90A 3elzB-4nk2A:
undetectable		 3elzB-4nk2A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		3 ASN A 689
HIS A 686
VAL A 685
 None
 0.91A 3elzB-4o5pA:
undetectable		 3elzB-4o5pA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		3 ASN A  57
HIS A  58
VAL A  65
 None
 0.80A 3elzB-4oraA:
undetectable		 3elzB-4oraA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		3 ASN A  90
HIS A  94
VAL A 392
 None
 0.82A 3elzB-4r1zA:
undetectable		 3elzB-4r1zA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2) 		3 ASN A 146
HIS A 147
VAL A 176
 None
 0.81A 3elzB-4r3aA:
0.7		 3elzB-4r3aA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		3 ASN A  68
HIS A  69
VAL A  72
 None
 0.67A 3elzB-4upkA:
undetectable		 3elzB-4upkA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1a MITORIBOSOMAL
PROTEIN ML48, MRPL48

(Sus scrofa) 		no annotation 3 ASN k  92
HIS k 189
VAL k  77
 None
 0.88A 3elzB-4v1ak:
undetectable		 3elzB-4v1ak:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 ASN C  66
HIS C  67
VAL C  87
 None
 0.78A 3elzB-4wpxC:
undetectable		 3elzB-4wpxC:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqo CULLIN-2

(Homo sapiens) 		PF00888
(Cullin) 		3 ASN D  67
HIS D  68
VAL D  25
 None
 0.76A 3elzB-4wqoD:
undetectable		 3elzB-4wqoD:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxo UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		3 ASN A 368
HIS A 371
VAL A 438
 None
 0.72A 3elzB-4wxoA:
undetectable		 3elzB-4wxoA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		3 ASN A 337
HIS A 336
VAL A 147
 None
 0.89A 3elzB-4y9lA:
undetectable		 3elzB-4y9lA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU) 		3 ASN A 728
HIS A 678
VAL A 719
 ASN  A 728 ( 0.6A)
HIS  A 678 ( 1.0A)
VAL  A 719 ( 0.6A)
 0.82A 3elzB-4zkeA:
undetectable		 3elzB-4zkeA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 ASN A 140
HIS A 141
VAL A 148
 None
None
F43  A 603 (-3.5A)
 0.84A 3elzB-5a8rA:
undetectable		 3elzB-5a8rA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		3 ASN C 125
HIS C 124
VAL C 500
 None
None
NFU  C 701 (-3.9A)
 0.86A 3elzB-5aa5C:
undetectable		 3elzB-5aa5C:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnd ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
epidermidis) 		no annotation 3 ASN A 417
HIS A 419
VAL A 427
 None
 0.87A 3elzB-5bndA:
undetectable		 3elzB-5bndA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ASN A 457
HIS A 458
VAL A 495
 None
 0.77A 3elzB-5bswA:
undetectable		 3elzB-5bswA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czj DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		3 ASN A 301
HIS A 299
VAL A 281
 None
 0.56A 3elzB-5czjA:
undetectable		 3elzB-5czjA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgk ACTIVE HELICASE

(Staphylococcus
aureus) 		PF06048
(DUF927) 		3 ASN A 496
HIS A 498
VAL A 447
 None
 0.87A 3elzB-5dgkA:
undetectable		 3elzB-5dgkA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezn CYSTEINE-RICH
PROTECTIVE ANTIGEN

(Plasmodium
falciparum) 		no annotation 3 ASN G 254
HIS G 240
VAL G 283
 None
 0.77A 3elzB-5eznG:
undetectable		 3elzB-5eznG:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezo C12 FAB

(Plasmodium
falciparum) 		no annotation 3 ASN A 254
HIS A 240
VAL A 283
 None
 0.82A 3elzB-5ezoA:
2.1		 3elzB-5ezoA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmv RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C

(Homo sapiens) 		PF00041
(fn3)
PF12567
(CD45) 		3 ASN A 372
HIS A 374
VAL A 235
 None
 0.79A 3elzB-5fmvA:
undetectable		 3elzB-5fmvA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gam PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08082
(PRO8NT)
PF08083
(PROCN) 		3 ASN A 257
HIS A 254
VAL A 565
 None
 0.90A 3elzB-5gamA:
undetectable		 3elzB-5gamA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 ASN A 536
HIS A 584
VAL A 583
 None
 0.87A 3elzB-5hjrA:
2.0		 3elzB-5hjrA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd6 MGS-MCHE2

(uncultured
bacterium) 		PF00561
(Abhydrolase_1) 		3 ASN A 183
HIS A 182
VAL A  66
 None
 0.91A 3elzB-5jd6A:
undetectable		 3elzB-5jd6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mul NEURAMINIDASE

(Bacteroides
thetaiotaomicron) 		PF15892
(BNR_4) 		3 ASN A 398
HIS A 386
VAL A 337
 None
 0.87A 3elzB-5mulA:
3.4		 3elzB-5mulA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 ASN A 140
HIS A 141
VAL A 148
 None
None
F43  A 604 (-3.5A)
 0.85A 3elzB-5n28A:
undetectable		 3elzB-5n28A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		3 ASN A1241
HIS A1245
VAL A1339
 None
 0.84A 3elzB-5n8oA:
undetectable		 3elzB-5n8oA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-8

(Caenorhabditis
elegans) 		PF10220
(Smg8_Smg9) 		3 ASN E 344
HIS E 346
VAL E 399
 None
 0.85A 3elzB-5nkmE:
undetectable		 3elzB-5nkmE:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oji DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Caenorhabditis
elegans) 		no annotation 3 ASN A  95
HIS A  96
VAL A 119
 NAP  A 301 (-2.9A)
None
None
 0.83A 3elzB-5ojiA:
undetectable		 3elzB-5ojiA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5omm CAPSID PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		3 ASN A 502
HIS A 500
VAL A 433
 None
 0.80A 3elzB-5ommA:
undetectable		 3elzB-5ommA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ov6 PORPHOBILINOGEN
DEAMINASE

(Bacillus
megaterium) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		3 ASN A  82
HIS A  78
VAL A  77
 AWQ  A 401 (-3.8A)
None
None
 0.80A 3elzB-5ov6A:
2.4		 3elzB-5ov6A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7

(Homo sapiens) 		PF01663
(Phosphodiest) 		3 ASN A  90
HIS A  91
VAL A  94
 None
 0.88A 3elzB-5udyA:
undetectable		 3elzB-5udyA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 3 ASN A 824
HIS A 825
VAL A 869
 None
 0.90A 3elzB-5vanA:
undetectable		 3elzB-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 3 ASN A 406
HIS A 407
VAL A 450
 None
 0.90A 3elzB-5w21A:
undetectable		 3elzB-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x04 DODECANOYL-[ACYL-CAR
RIER-PROTEIN]
HYDROLASE,
CHLOROPLASTIC

(Umbellularia
californica) 		no annotation 3 ASN A 139
HIS A 140
VAL A 106
 None
 0.90A 3elzB-5x04A:
undetectable		 3elzB-5x04A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9u THERMOSOME, ALPHA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		no annotation 3 ASN A 125
HIS A 126
VAL A 401
 None
 0.67A 3elzB-5x9uA:
undetectable		 3elzB-5x9uA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 3 ASN A 235
HIS A 237
VAL A 239
 None
 0.76A 3elzB-6b6lA:
undetectable		 3elzB-6b6lA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1

(Danio rerio) 		no annotation 3 ASN A  90
HIS A  94
VAL A 392
 None
 0.69A 3elzB-6b82A:
undetectable		 3elzB-6b82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-) 		no annotation 3 ASN D 107
HIS D 108
VAL D 165
 None
 0.56A 3elzB-6gsaD:
undetectable		 3elzB-6gsaD:
undetectable