SIMILAR PATTERNS OF AMINO ACIDS FOR 3ELZ_B_CHDB151_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csy SYK PROTEIN TYROSINE
KINASE

(Homo sapiens) 		PF00017
(SH2) 		5 TYR A  91
ILE A  41
ILE A  65
GLY A  78
LEU A 102
 None
 1.03A 3elzB-1csyA:
0.9		 3elzB-1csyA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dot DUCK OVOTRANSFERRIN

(Anas
platyrhynchos) 		PF00405
(Transferrin) 		5 ILE A 138
ILE A 129
GLY A 124
PRO A 162
LEU A 109
 None
None
CO3  A 689 (-3.7A)
None
None
 1.24A 3elzB-1dotA:
0.0		 3elzB-1dotA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 ILE A 174
ILE A 196
PHE A 287
TYR A  89
ARG A 207
 None
None
DCA  A 801 ( 4.5A)
DCA  A 801 (-4.0A)
B12  A 800 (-3.9A)
 1.35A 3elzB-1e1cA:
0.0		 3elzB-1e1cA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1et9 SUPERANTIGEN SPE-H

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 TYR A 172
ILE A 139
ILE A 144
GLY A 155
LEU A  11
 None
 1.28A 3elzB-1et9A:
0.0		 3elzB-1et9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF06470
(SMC_hinge) 		5 ILE A 524
GLY A 610
PHE A 612
LEU A 537
ARG A 638
 None
 1.33A 3elzB-1gxlA:
undetectable		 3elzB-1gxlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ILE A 201
ILE A 196
PHE A 130
TYR A 112
VAL A  94
 None
 1.39A 3elzB-1ig8A:
0.0		 3elzB-1ig8A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1d D-HYDANTOINASE

(Geobacillus
stearothermophilus) 		PF01979
(Amidohydro_1) 		5 ILE A 341
GLY A  85
PHE A 396
VAL A 423
LEU A 312
 None
 1.35A 3elzB-1k1dA:
0.0		 3elzB-1k1dA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9x M32 CARBOXYPEPTIDASE

(Pyrococcus
furiosus) 		PF02074
(Peptidase_M32) 		5 ILE A 219
GLY A 272
PHE A 304
VAL A 448
LEU A 265
 None
 1.27A 3elzB-1k9xA:
undetectable		 3elzB-1k9xA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kob TWITCHIN

(Aplysia
californica) 		PF00069
(Pkinase) 		5 ILE A 111
ILE A 193
GLY A 133
PRO A 341
VAL A  67
 None
 1.29A 3elzB-1kobA:
0.0		 3elzB-1kobA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m93 SERINE PROTEINASE
INHIBITOR 2
SERINE PROTEINASE
INHIBITOR 2

(Cowpox virus;
Cowpox virus) 		PF00079
(Serpin)
PF00079
(Serpin) 		5 TYR B 244
GLY B 242
PHE A  17
VAL B 131
LEU B 246
 None
 1.33A 3elzB-1m93B:
undetectable		 3elzB-1m93B:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mld MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 113
ILE A  74
GLY A   7
VAL A 235
LEU A  66
 None
 1.38A 3elzB-1mldA:
undetectable		 3elzB-1mldA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 TYR C  28
ILE C  64
GLY C   6
VAL C  80
LEU C  52
 None
 1.22A 3elzB-1n8yC:
undetectable		 3elzB-1n8yC:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ILE A 724
ILE A 719
GLY A 470
PHE A 469
LEU A 737
 None
None
6FA  A 801 ( 4.0A)
None
6FA  A 801 (-4.8A)
 1.21A 3elzB-1naaA:
undetectable		 3elzB-1naaA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si1 IRON BINDING PROTEIN
FBPA

(Mannheimia
haemolytica) 		PF13343
(SBP_bac_6) 		5 ILE A 297
ILE A 292
GLY A 226
PHE A 287
LEU A 146
 None
 1.22A 3elzB-1si1A:
undetectable		 3elzB-1si1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni) 		PF13580
(SIS_2) 		5 ILE A  47
ILE A  45
GLY A  32
TYR A  68
LEU A 143
 None
 1.14A 3elzB-1tk9A:
undetectable		 3elzB-1tk9A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		5 ILE A 344
ILE A 332
GLY A 580
TYR A 743
PRO A 740
 None
 0.93A 3elzB-1z26A:
0.9		 3elzB-1z26A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Pyrococcus
abyssi) 		PF00710
(Asparaginase) 		5 ILE A 346
ILE A 347
GLY A 379
PRO A 389
VAL A 360
 None
 1.29A 3elzB-1zq1A:
undetectable		 3elzB-1zq1A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a62 CADHERIN-8

(Mus musculus) 		PF00028
(Cadherin) 		5 ILE A 319
ILE A 234
GLY A 231
LEU A 262
ARG A 279
 None
 1.40A 3elzB-2a62A:
undetectable		 3elzB-2a62A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arh HYPOTHETICAL PROTEIN
AQ_1966

(Aquifex
aeolicus) 		PF06557
(DUF1122) 		5 ILE A  15
GLY A  79
PHE A  78
VAL A  66
LEU A  42
 None
 1.15A 3elzB-2arhA:
2.3		 3elzB-2arhA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 TYR A 162
ILE A 102
GLY A 405
VAL A 442
LEU A 159
 None
 1.40A 3elzB-2g3nA:
undetectable		 3elzB-2g3nA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhe TRANSCRIPTION
REGULATOR TYRR

(Escherichia
coli) 		PF13188
(PAS_8) 		5 ILE A  31
ILE A  33
GLY A  37
PHE A   6
LEU A  17
 None
AE3  A1191 (-4.6A)
AE3  A1191 (-3.4A)
None
None
 1.18A 3elzB-2jheA:
undetectable		 3elzB-2jheA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		5 ILE A  98
GLY A 255
PRO A  53
VAL A 248
LEU A 412
 None
 1.38A 3elzB-2n0sA:
undetectable		 3elzB-2n0sA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 379
ILE A 102
GLY A 299
VAL A 322
LEU A 120
 None
 1.31A 3elzB-2o56A:
0.7		 3elzB-2o56A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 373
ILE A  98
GLY A 293
VAL A 316
LEU A 116
 None
 1.30A 3elzB-2ox4A:
undetectable		 3elzB-2ox4A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv3 VACUOLATING
CYTOTOXIN

(Helicobacter
pylori) 		PF02691
(VacA) 		5 TYR A 703
ILE A 679
ILE A 787
GLY A 784
VAL A 656
 None
 1.37A 3elzB-2qv3A:
undetectable		 3elzB-2qv3A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uur COLLAGEN ALPHA-1(IX)
CHAIN

(Homo sapiens) 		no annotation 5 ILE A 123
ILE A 121
PHE A 172
PRO A 224
LEU A 149
 None
 1.32A 3elzB-2uurA:
undetectable		 3elzB-2uurA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus) 		PF00294
(PfkB) 		5 ILE A 282
GLY A 228
PRO A 253
VAL A 288
LEU A 224
 ANP  A1315 ( 3.9A)
AMP  A1316 ( 3.4A)
None
None
None
 1.41A 3elzB-2varA:
undetectable		 3elzB-2varA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A 177
ILE A 178
GLY A 181
PRO A 126
LEU A 195
 None
 1.25A 3elzB-2vdcA:
undetectable		 3elzB-2vdcA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3biw NEUROLIGIN-1

(Rattus
norvegicus) 		PF00135
(COesterase) 		5 ILE A 265
ILE A 224
PRO A  53
VAL A  55
LEU A 156
 None
 1.26A 3elzB-3biwA:
undetectable		 3elzB-3biwA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		5 ILE A 417
ILE A 337
GLY A 358
PRO A 395
VAL A 392
 None
 1.12A 3elzB-3bs8A:
undetectable		 3elzB-3bs8A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3by9 SENSOR PROTEIN

(Vibrio cholerae) 		PF02743
(dCache_1) 		5 ILE A 123
ILE A 111
GLY A 170
TYR A 132
LEU A  89
 None
None
None
SIN  A 287 (-4.4A)
None
 1.37A 3elzB-3by9A:
undetectable		 3elzB-3by9A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgy VIRULENCE SENSOR
HISTIDINE KINASE
PHOQ

(Salmonella
enterica) 		PF02518
(HATPase_c) 		5 ILE A 401
ILE A 367
PHE A 373
VAL A 475
LEU A 348
 None
 1.21A 3elzB-3cgyA:
1.5		 3elzB-3cgyA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		5 TYR C  63
ILE C  24
ILE C  27
VAL C 159
LEU C  73
 None
 1.01A 3elzB-3degC:
undetectable		 3elzB-3degC:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		5 ILE X 304
ILE X 299
GLY X 233
PHE X 294
LEU X 150
 None
 1.16A 3elzB-3e13X:
undetectable		 3elzB-3e13X:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ect HEXAPEPTIDE-REPEAT
CONTAINING-ACETYLTRA
NSFERASE

(Vibrio cholerae) 		PF00132
(Hexapep)
PF12464
(Mac) 		5 ILE A  74
ILE A  96
PHE A  81
VAL A  86
LEU A  56
 None
 1.27A 3elzB-3ectA:
undetectable		 3elzB-3ectA:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		10 TYR A  14
ILE A  21
ILE A  23
GLY A  31
PHE A  34
TYR A  53
PRO A  54
VAL A  74
LEU A 123
ARG A 125
 CHD  A 151 (-4.9A)
CHD  A 153 ( 4.1A)
CHD  A 200 ( 4.7A)
CHD  A 151 (-3.6A)
CHD  A 151 ( 4.6A)
CHD  A 151 (-4.5A)
None
CHD  A 200 (-3.7A)
CHD  A 151 (-4.2A)
CHD  A 151 (-4.1A)
 0.53A 3elzB-3elzA:
24.8		 3elzB-3elzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g69 SORTASE C

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		5 ILE A 115
ILE A 122
GLY A 138
PRO A  87
LEU A 182
 None
 1.41A 3elzB-3g69A:
undetectable		 3elzB-3g69A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		5 ILE A 110
ILE A  72
GLY A  75
TYR A 553
PRO A 552
 None
 1.31A 3elzB-3gf7A:
undetectable		 3elzB-3gf7A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gka N-ETHYLMALEIMIDE
REDUCTASE

(Burkholderia
pseudomallei) 		PF00724
(Oxidored_FMN) 		5 ILE A 264
GLY A 253
PHE A 252
PRO A 236
LEU A 215
 None
 1.03A 3elzB-3gkaA:
undetectable		 3elzB-3gkaA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF01030
(Recep_L_domain) 		5 TYR A  28
ILE A  64
GLY A   6
VAL A  80
LEU A  52
 None
 1.20A 3elzB-3h3bA:
undetectable		 3elzB-3h3bA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihx PR DOMAIN ZINC
FINGER PROTEIN 10

(Homo sapiens) 		no annotation 5 ILE A  64
GLY A  47
PRO A  22
VAL A  34
LEU A  88
 None
 1.30A 3elzB-3ihxA:
undetectable		 3elzB-3ihxA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsa HOMOSERINE
DEHYDROGENASE

(Thermoplasma
volcanium) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 ILE A  22
GLY A  10
PHE A   9
VAL A  38
LEU A 320
 None
NAD  A 501 (-3.4A)
None
None
None
 1.31A 3elzB-3jsaA:
undetectable		 3elzB-3jsaA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA

(Methylobacillus
flagellatus) 		PF08886
(GshA) 		5 ILE A 225
ILE A  28
GLY A 405
VAL A 217
LEU A  17
 None
None
None
GOL  A 446 ( 4.1A)
None
 1.16A 3elzB-3k1tA:
undetectable		 3elzB-3k1tA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksd GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
1

(Staphylococcus
aureus) 		no annotation 5 ILE Q 217
ILE Q 224
GLY Q 168
PHE Q 167
LEU Q 245
 None
 1.36A 3elzB-3ksdQ:
undetectable		 3elzB-3ksdQ:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky8 PUTATIVE RIBOFLAVIN
BIOSYNTHESIS PROTEIN

(Shewanella
loihica) 		PF01872
(RibD_C) 		5 ILE A  15
ILE A   7
PHE A  38
TYR A  67
LEU A  25
 UNL  A 180 ( 4.3A)
None
UNL  A 179 ( 3.8A)
None
None
 1.35A 3elzB-3ky8A:
undetectable		 3elzB-3ky8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfd D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACB

(Bacillus
subtilis) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 ILE A 292
ILE A 278
PHE A 285
PRO A 317
VAL A 332
 None
 1.31A 3elzB-3mfdA:
2.8		 3elzB-3mfdA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpi GLUTARYL-COA
DEHYDROGENASE

(Desulfococcus
multivorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 TYR A 171
ILE A 128
GLY A 155
PHE A 216
LEU A 169
 None
FAD  A 400 (-3.5A)
None
None
None
 1.18A 3elzB-3mpiA:
undetectable		 3elzB-3mpiA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oum TOXOFLAVIN-DEGRADING
ENZYME

(Paenibacillus
polymyxa) 		PF00903
(Glyoxalase) 		5 ILE A 136
ILE A  46
PHE A  20
PRO A 107
LEU A 133
 None
 1.12A 3elzB-3oumA:
undetectable		 3elzB-3oumA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 TYR A 408
ILE A 212
GLY A 272
TYR A 126
LEU A 409
 None
 1.26A 3elzB-3u95A:
undetectable		 3elzB-3u95A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9i MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Roseiflexus sp.
RS-1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 295
ILE A 292
GLY A 285
PRO A  95
ARG A  88
 None
 1.22A 3elzB-3u9iA:
undetectable		 3elzB-3u9iA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aly P35 ANTIGEN

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		5 ILE A 286
ILE A 283
GLY A 197
PHE A 198
LEU A 236
 None
 1.11A 3elzB-4alyA:
undetectable		 3elzB-4alyA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg5 BBA65

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		5 ILE A 120
ILE A 123
GLY A 126
TYR A  90
LEU A  58
 None
 1.22A 3elzB-4bg5A:
undetectable		 3elzB-4bg5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		5 ILE A 526
ILE A 524
GLY A 518
PHE A 467
LEU A 486
 None
 1.20A 3elzB-4bl3A:
1.2		 3elzB-4bl3A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ILE A  82
ILE A 107
GLY A 343
PRO A 276
LEU A  27
 None
 0.88A 3elzB-4dpkA:
undetectable		 3elzB-4dpkA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola) 		PF13354
(Beta-lactamase2) 		5 ILE A 279
ILE A 221
GLY A 232
PHE A 211
VAL A 186
 None
 1.05A 3elzB-4ev4A:
1.1		 3elzB-4ev4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0q RESTRICTION
ENDONUCLEASE

(Mycobacterium
sp. JLS) 		PF04471
(Mrr_cat) 		6 TYR A 114
ILE A  85
ILE A  68
GLY A 116
PRO A 126
LEU A 208
 None
 1.48A 3elzB-4f0qA:
undetectable		 3elzB-4f0qA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN

(Enterococcus
faecalis) 		PF00497
(SBP_bac_3) 		5 TYR A 106
ILE A 238
ILE A  48
GLY A  89
LEU A 226
 None
None
None
GLN  A 302 (-4.9A)
None
 1.11A 3elzB-4g4pA:
undetectable		 3elzB-4g4pA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0c PHOSPHOLIPASE/CARBOX
YLESTERASE

(Dyadobacter
fermentans) 		PF02230
(Abhydrolase_2) 		5 ILE A  36
ILE A  35
PHE A 101
VAL A  85
LEU A  44
 None
 1.13A 3elzB-4h0cA:
undetectable		 3elzB-4h0cA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr1 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
abyssi virus 1) 		no annotation 5 ILE B  91
ILE B  92
GLY B 106
VAL B  98
LEU B 114
 None
 1.36A 3elzB-4hr1B:
undetectable		 3elzB-4hr1B:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jfc ENOYL-COA HYDRATASE

(Polaromonas sp.
JS666) 		PF00378
(ECH_1) 		5 ILE A  91
GLY A 146
PHE A 114
VAL A 123
LEU A  27
 None
 1.34A 3elzB-4jfcA:
undetectable		 3elzB-4jfcA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN

(Lactococcus
lactis) 		PF00497
(SBP_bac_3) 		5 TYR A 111
ILE A 243
ILE A  53
GLY A  94
LEU A 231
 None
None
None
MES  A 301 (-4.6A)
None
 1.15A 3elzB-4kptA:
undetectable		 3elzB-4kptA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpt GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN

(Lactococcus
lactis) 		PF00497
(SBP_bac_3) 		5 TYR A 111
ILE A 243
ILE A  53
GLY A  94
TYR A  73
 None
None
None
MES  A 301 (-4.6A)
None
 1.14A 3elzB-4kptA:
undetectable		 3elzB-4kptA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l39 4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12

(Arabidopsis
thaliana) 		PF03321
(GH3) 		5 ILE A 273
ILE A 276
GLY A 284
VAL A 211
LEU A 229
 None
 1.28A 3elzB-4l39A:
undetectable		 3elzB-4l39A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Caldanaerobacter
subterraneus) 		no annotation 5 ILE B 198
ILE B  38
GLY B  45
VAL B   5
LEU B  87
 None
None
SO4  B 301 (-3.4A)
None
None
 0.93A 3elzB-4mkiB:
undetectable		 3elzB-4mkiB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwv CAPSID PROTEIN

(Orsay virus) 		PF11729
(Capsid-VNN) 		5 ILE A  80
GLY A 374
PHE A 377
PRO A 364
ARG A 383
 None
 1.07A 3elzB-4nwvA:
undetectable		 3elzB-4nwvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nww CAPSID PROTEIN

(Orsay virus) 		PF11729
(Capsid-VNN) 		5 ILE A  80
GLY A 374
PHE A 377
PRO A 364
ARG A 383
 None
 1.06A 3elzB-4nwwA:
undetectable		 3elzB-4nwwA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		5 TYR A 350
ILE A 481
ILE A 292
GLY A 333
LEU A 469
 None
None
None
ACT  A 507 (-4.7A)
None
 1.18A 3elzB-4oenA:
undetectable		 3elzB-4oenA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qp0 ENDO-BETA-MANNANASE

(Rhizomucor
miehei) 		PF00150
(Cellulase) 		5 ILE A  93
ILE A  89
GLY A  85
VAL A  37
LEU A 156
 None
 1.32A 3elzB-4qp0A:
undetectable		 3elzB-4qp0A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF16819
(DUF5074)
PF16820
(PKD_3) 		5 ILE A 360
ILE A 361
GLY A 351
PRO A 339
LEU A 407
 None
None
7PE  A 503 ( 3.8A)
None
None
 1.42A 3elzB-4r5oA:
undetectable		 3elzB-4r5oA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1v D-3-PHOSPHOGLYCERATE
DEHYDROGENASE-RELATE
D PROTEIN

(Vibrio cholerae) 		no annotation 5 ILE D 172
ILE D 151
GLY D 155
PRO D 102
LEU D 187
 None
 1.08A 3elzB-4s1vD:
undetectable		 3elzB-4s1vD:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwj TENA/THI-4 FAMILY
PROTEIN

(Pseudomonas
protegens) 		PF14518
(Haem_oxygenas_2) 		5 ILE A 151
ILE A 148
GLY A 214
PHE A   5
TYR A  17
 None
 1.16A 3elzB-4wwjA:
undetectable		 3elzB-4wwjA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwj TENA/THI-4 FAMILY
PROTEIN

(Pseudomonas
protegens) 		PF14518
(Haem_oxygenas_2) 		5 ILE A 151
ILE A 148
PHE A   5
TYR A  17
PRO A  18
 None
 0.87A 3elzB-4wwjA:
undetectable		 3elzB-4wwjA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1k OUTER MEMBRANE
PROTEIN OPRM

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		5 ILE A 275
ILE A 362
TYR A  18
PRO A  19
VAL A 369
 None
 1.36A 3elzB-4y1kA:
undetectable		 3elzB-4y1kA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zef AMINO ACID ABC
TRANSPORTER AMINO
ACID-BINDING/PERMEAS
E

(Enterococcus
faecalis) 		PF00497
(SBP_bac_3) 		5 TYR A 343
ILE A 475
ILE A 285
GLY A 326
LEU A 463
 None
 1.12A 3elzB-4zefA:
undetectable		 3elzB-4zefA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		5 ILE A 696
ILE A 715
PRO A 731
VAL A 728
LEU A 822
 None
 1.39A 3elzB-4zhjA:
undetectable		 3elzB-4zhjA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsx UNCHARACTERIZED
FUSION PROTEIN

(Pseudomonas
aeruginosa;
Aquifex
aeolicus) 		PF06557
(DUF1122) 		5 ILE A  15
GLY A  79
PHE A  78
VAL A  66
LEU A  42
 None
 1.23A 3elzB-4zsxA:
2.6		 3elzB-4zsxA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		5 ILE A 269
ILE A 274
GLY A 280
LEU A 331
ARG A 287
 None
 1.38A 3elzB-5c1bA:
undetectable		 3elzB-5c1bA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 5 ILE C 106
ILE C 105
GLY C 338
PHE C 337
VAL C 283
 None
 1.26A 3elzB-5gp4C:
undetectable		 3elzB-5gp4C:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9x BETA-1,3-GLUCANASE

(Paenibacillus
barengoltzii) 		PF16483
(Glyco_hydro_64) 		5 ILE A 416
ILE A  98
GLY A 420
PHE A 256
VAL A 235
 None
 1.25A 3elzB-5h9xA:
undetectable		 3elzB-5h9xA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj7 GLUTAMATE RACEMASE

(Mycobacterium
tuberculosis) 		PF01177
(Asp_Glu_race) 		5 ILE A  24
GLY A   9
PHE A  11
VAL A  97
LEU A  18
 None
 1.15A 3elzB-5hj7A:
undetectable		 3elzB-5hj7A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijw GLUTAMATE RACEMASE

(Mycolicibacterium
smegmatis) 		PF01177
(Asp_Glu_race) 		5 ILE A  24
GLY A   9
PHE A  11
VAL A  98
LEU A  18
 None
 1.14A 3elzB-5ijwA:
undetectable		 3elzB-5ijwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcn OS09G0567300 PROTEIN

(Oryza sativa) 		PF07992
(Pyr_redox_2) 		5 ILE A  88
ILE A  37
GLY A  15
VAL A 327
LEU A  78
 None
None
FAD  A 500 (-3.2A)
None
None
 1.07A 3elzB-5jcnA:
undetectable		 3elzB-5jcnA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knl UBIQUITIN-CONJUGATIN
G ENZYME E2 15

(Schizosaccharomyces
pombe) 		PF00179
(UQ_con) 		5 ILE C 122
ILE C 125
GLY C  44
PHE C  54
VAL C  40
 None
 1.41A 3elzB-5knlC:
undetectable		 3elzB-5knlC:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf7 PROTEASOME SUBUNIT
BETA TYPE-1

(Homo sapiens) 		PF00227
(Proteasome) 		5 ILE L  52
ILE L 110
GLY L  86
VAL L 198
LEU L  72
 None
 1.30A 3elzB-5lf7L:
1.7		 3elzB-5lf7L:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li8 PUTATIVE CYTOCHROME
P450 126

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 ILE A 262
ILE A 149
GLY A 132
LEU A 126
ARG A 127
 None
 1.30A 3elzB-5li8A:
undetectable		 3elzB-5li8A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT

(Ovis aries) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N)
PF06455
(NADH5_C) 		5 ILE L 472
ILE L 468
GLY L 388
PHE L 389
LEU L 324
 None
 1.36A 3elzB-5lnkL:
undetectable		 3elzB-5lnkL:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lst ATP-DEPENDENT DNA
HELICASE Q4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE A 703
ILE A 705
TYR A 798
PRO A 792
LEU A 691
 None
 1.36A 3elzB-5lstA:
undetectable		 3elzB-5lstA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m4a NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 714
ILE A 189
GLY A 705
PHE A 706
LEU A 318
 None
None
None
TRE  A 801 (-4.7A)
None
 1.28A 3elzB-5m4aA:
undetectable		 3elzB-5m4aA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mxp -

(-) 		no annotation 5 ILE A 122
ILE A 101
GLY A 107
PHE A 109
LEU A 230
 None
 1.24A 3elzB-5mxpA:
undetectable		 3elzB-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n72 WIPA

(Legionella
pneumophila) 		no annotation 5 ILE A 208
GLY A 214
TYR A 221
VAL A 265
LEU A 328
 None
ACT  A 504 ( 4.9A)
None
None
None
 1.01A 3elzB-5n72A:
undetectable		 3elzB-5n72A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4

(Homo sapiens) 		no annotation 5 ILE A  24
ILE A  45
GLY A 404
TYR A 395
LEU A 409
 ILE  A  24 ( 0.7A)
ILE  A  45 ( 0.7A)
GLY  A 404 ( 0.0A)
TYR  A 395 ( 1.3A)
LEU  A 409 ( 0.5A)
 1.35A 3elzB-5nksA:
undetectable		 3elzB-5nksA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 5 TYR C  28
ILE C  64
GLY C   6
VAL C  80
LEU C  52
 None
 1.24A 3elzB-5o4gC:
undetectable		 3elzB-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis) 		no annotation 5 ILE A 631
GLY A 624
PHE A 607
TYR A 174
VAL A 178
 None
 1.17A 3elzB-5uj1A:
undetectable		 3elzB-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Lassa
mammarenavirus) 		PF00798
(Arena_glycoprot) 		5 ILE A 136
ILE A  95
TYR A 166
VAL A 164
LEU A 244
 None
 1.39A 3elzB-5vk2A:
undetectable		 3elzB-5vk2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 5 TYR A 548
GLY A 486
PHE A 485
VAL A 403
LEU A 318
 None
 1.41A 3elzB-5wabA:
1.5		 3elzB-5wabA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbf UNCONVENTIONAL
MYOSIN-VIIB

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		5 TYR A1711
ILE A1755
ILE A1771
PHE A1697
LEU A1715
 None
 1.40A 3elzB-5xbfA:
undetectable		 3elzB-5xbfA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9d ACYL-COENZYME A
OXIDASE 1

(Yarrowia
lipolytica) 		no annotation 5 ILE A 332
ILE A 331
GLY A 420
VAL A 645
LEU A 341
 None
 1.25A 3elzB-5y9dA:
undetectable		 3elzB-5y9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys9 ACYL-COENZYME A
OXIDASE 3

(Yarrowia
lipolytica) 		no annotation 5 ILE A 345
GLY A 434
PRO A 647
VAL A 655
LEU A 355
 None
 1.39A 3elzB-5ys9A:
undetectable		 3elzB-5ys9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8

(Homo sapiens) 		no annotation 5 ILE E 701
ILE E 907
GLY E 905
PRO E 694
LEU E 723
 None
 1.42A 3elzB-6c3pE:
undetectable		 3elzB-6c3pE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 5 ILE A 582
ILE A 584
GLY A 426
VAL A 591
LEU A 414
 None
 1.41A 3elzB-6fn1A:
undetectable		 3elzB-6fn1A:
undetectable