SIMILAR PATTERNS OF AMINO ACIDS FOR 3ELZ_B_CHDB150_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5y ROB TRANSCRIPTION
FACTOR

(Escherichia
coli) 		PF06445
(GyrI-like)
PF12833
(HTH_18) 		5 THR A 184
VAL A 196
LEU A 284
ILE A 285
TYR A 244
 None
 1.37A 3elzB-1d5yA:
0.0		 3elzB-1d5yA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F

(Escherichia
coli) 		PF00267
(Porin_1) 		5 THR A 276
VAL A 257
VAL A 326
LEU A 324
ILE A 318
 None
 1.43A 3elzB-1gfnA:
1.4		 3elzB-1gfnA:
17.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1u GASTROTROPIN

(Homo sapiens) 		PF14651
(Lipocalin_7) 		5 TRP A  49
GLN A  51
VAL A  83
LEU A  90
TYR A  97
 None
 0.84A 3elzB-1o1uA:
15.7		 3elzB-1o1uA:
56.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1u GASTROTROPIN

(Homo sapiens) 		PF14651
(Lipocalin_7) 		5 TRP A  49
GLN A  51
VAL A  83
TYR A  97
GLN A  99
 None
 1.15A 3elzB-1o1uA:
15.7		 3elzB-1o1uA:
56.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		5 THR A 324
VAL A 289
LEU A 283
TYR A 419
THR A 334
 None
 1.17A 3elzB-1ua4A:
0.0		 3elzB-1ua4A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa6 BETA2-CHIMAERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 THR A 443
LEU A 453
ILE A 371
TYR A 367
GLN A 451
 None
 1.50A 3elzB-1xa6A:
0.6		 3elzB-1xa6A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 THR A 379
VAL A 241
LEU A 296
ILE A 245
THR A 299
 None
 1.48A 3elzB-2cjqA:
0.0		 3elzB-2cjqA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 THR A 154
VAL A 153
VAL A 338
ILE A 339
THR A 356
 None
 1.47A 3elzB-2f9qA:
undetectable		 3elzB-2f9qA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghi TRANSPORT PROTEIN

(Plasmodium
yoelii) 		PF00005
(ABC_tran) 		5 GLN A  30
VAL A  23
LEU A  65
ILE A  39
THR A  61
 SO4  A2003 (-4.9A)
None
None
None
None
 1.36A 3elzB-2ghiA:
0.0		 3elzB-2ghiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwg 4-OXALOMESACONATE
HYDRATASE

(Rhodopseudomonas
palustris) 		PF04909
(Amidohydro_2) 		5 GLN A 264
THR A 303
VAL A 276
ILE A 321
TYR A 322
 None
 1.31A 3elzB-2gwgA:
undetectable		 3elzB-2gwgA:
16.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lba BABP PROTEIN

(Gallus gallus) 		PF14651
(Lipocalin_7) 		6 TRP A  49
GLN A  51
MET A  71
THR A  73
VAL A  83
TYR A  97
 CHO  A 201 (-2.9A)
CHO  A 201 ( 3.4A)
CHO  A 201 (-2.4A)
CHO  A 201 (-2.8A)
CHO  A 201 ( 4.0A)
CHO  A 201 (-2.6A)
 0.97A 3elzB-2lbaA:
19.0		 3elzB-2lbaA:
60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 VAL A 320
ILE A 169
TYR A 344
GLN A 342
THR A 339
 None
 1.10A 3elzB-2r9vA:
undetectable		 3elzB-2r9vA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 VAL A 725
VAL A 545
LEU A 599
ILE A 549
TYR A 586
 None
 1.43A 3elzB-2xt6A:
undetectable		 3elzB-2xt6A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtq COLICIN-M

(Escherichia
coli) 		PF14859
(Colicin_M) 		5 THR A 234
VAL A 146
ILE A 257
TYR A 255
THR A 128
 None
 1.42A 3elzB-2xtqA:
3.3		 3elzB-2xtqA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE

(Desulfovibrio
alaskensis) 		PF09837
(DUF2064) 		5 MET A 175
LEU A 183
ILE A 134
TYR A 168
GLN A 184
 None
 1.14A 3elzB-3cgxA:
undetectable		 3elzB-3cgxA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpi NAD+ SYNTHETASE

(Burkholderia
pseudomallei) 		PF02540
(NAD_synthase) 		5 THR A 217
VAL A 200
LEU A 192
TYR A 239
THR A 168
 None
 1.47A 3elzB-3dpiA:
undetectable		 3elzB-3dpiA:
18.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		11 TRP A  49
GLN A  51
MET A  71
THR A  73
VAL A  74
VAL A  83
LEU A  90
ILE A  92
TYR A  97
GLN A  99
THR A 101
 CHD  A 150 (-3.5A)
CHD  A 150 ( 3.7A)
CHD  A 150 ( 3.7A)
CHD  A 200 (-3.1A)
CHD  A 200 (-3.7A)
CHD  A 150 (-4.4A)
CHD  A 150 (-4.4A)
CHD  A 150 (-3.9A)
CHD  A 153 (-4.2A)
CHD  A 150 (-3.3A)
CHD  A 150 (-2.9A)
 0.41A 3elzB-3elzA:
24.8		 3elzB-3elzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd4 PUTATIVE PROTEASE

(Parabacteroides
distasonis) 		PF12969
(DUF3857)
PF12970
(DUF3858) 		5 THR A 354
VAL A 355
VAL A 376
ILE A 384
THR A 368
 None
 1.20A 3elzB-3kd4A:
0.6		 3elzB-3kd4A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldh LACTATE
DEHYDROGENASE

(Squalus
acanthias) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLN A 314
VAL A 285
LEU A 322
ILE A 281
THR A 321
 None
 1.39A 3elzB-3ldhA:
undetectable		 3elzB-3ldhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		5 GLN B 305
THR B 301
VAL B 302
LEU B 418
ILE B 420
 None
 1.20A 3elzB-3q75B:
undetectable		 3elzB-3q75B:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Lactobacillus
acidophilus) 		PF00215
(OMPdecase) 		5 VAL A 213
VAL A 119
LEU A 122
ILE A 160
THR A 123
 None
 1.31A 3elzB-3tfxA:
undetectable		 3elzB-3tfxA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 THR A  60
VAL A 129
LEU A 127
ILE A 142
TYR A 155
 None
 1.40A 3elzB-3wfaA:
undetectable		 3elzB-3wfaA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 VAL A 725
VAL A 545
LEU A 599
ILE A 549
TYR A 586
 None
 1.45A 3elzB-3zhrA:
undetectable		 3elzB-3zhrA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		5 THR A 128
VAL A 127
VAL A 183
ILE A 173
THR A 196
 None
 1.22A 3elzB-3zs6A:
undetectable		 3elzB-3zs6A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		5 GLN X 240
THR X 302
VAL X 220
LEU X 275
ILE X 211
 None
 1.41A 3elzB-3zyyX:
undetectable		 3elzB-3zyyX:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ees PHOTOTROPIN-2

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		5 THR A 453
VAL A 454
VAL A 475
ILE A 486
THR A 394
 None
None
None
None
FMN  A1001 (-3.3A)
 1.25A 3elzB-4eesA:
1.7		 3elzB-4eesA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 5 THR A 413
VAL A 414
VAL A 399
ILE A 395
TYR A 391
 None
 1.12A 3elzB-4qnlA:
0.5		 3elzB-4qnlA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq7 PUTATIVE STRINGENT
STARVATION PROTEIN A

(Burkholderia
cenocepacia) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 MET A  25
VAL A  19
LEU A  79
ILE A  70
TYR A  69
 None
 1.48A 3elzB-4qq7A:
undetectable		 3elzB-4qq7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		5 TRP A 209
GLN A 180
THR A  82
VAL A  81
ILE A  86
 None
 1.26A 3elzB-4r9oA:
undetectable		 3elzB-4r9oA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9x COPPER HOMEOSTASIS
PROTEIN CUTC

(Bacillus
anthracis) 		PF03932
(CutC) 		5 GLN A 172
MET A 132
LEU A 160
GLN A 164
THR A 191
 None
 1.50A 3elzB-4r9xA:
undetectable		 3elzB-4r9xA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA

(Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N) 		5 THR A 123
VAL A 109
VAL A  85
ILE A  84
THR A 118
 None
 1.44A 3elzB-4rltA:
1.8		 3elzB-4rltA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER

(Escherichia
coli) 		PF01554
(MatE) 		5 THR A 127
VAL A 128
VAL A  74
LEU A 141
TYR A 156
 None
 1.44A 3elzB-4z3nA:
undetectable		 3elzB-4z3nA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7h IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		PF01833
(TIG) 		5 THR A 350
VAL A 337
VAL A 318
LEU A 315
ILE A 325
 None
 1.42A 3elzB-5e7hA:
undetectable		 3elzB-5e7hA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 TRP B 648
VAL B 604
VAL B 735
LEU B 766
THR B 763
 None
 1.42A 3elzB-5eduB:
undetectable		 3elzB-5eduB:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsg MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HANTAVIRUS
NUCLEOPROTEIN

(Hantaan
orthohantavirus) 		PF00846
(Hanta_nucleocap)
PF13416
(SBP_bac_8) 		5 GLN A 375
THR A 369
ILE A 381
TYR A 362
GLN A 378
 None
 1.26A 3elzB-5fsgA:
undetectable		 3elzB-5fsgA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lac 3CL PROTEASE

(Alphamesonivirus
1) 		PF17222
(Peptidase_C107) 		5 MET A 156
THR A 117
VAL A 116
VAL A  39
ILE A 103
 None
 1.32A 3elzB-5lacA:
undetectable		 3elzB-5lacA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 5 GLN A 413
THR A 538
VAL A 537
LEU A 149
ILE A 147
 None
 1.35A 3elzB-5m6gA:
undetectable		 3elzB-5m6gA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 5 THR A 538
VAL A 537
LEU A 149
ILE A 147
THR A 152
 None
 1.31A 3elzB-5m6gA:
undetectable		 3elzB-5m6gA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE

(Trypanosoma
brucei) 		PF00156
(Pribosyltran) 		5 THR A 202
VAL A 201
VAL A  45
LEU A  85
ILE A  48
 None
 1.31A 3elzB-5vn4A:
undetectable		 3elzB-5vn4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1a MYOSIN HEAVY CHAIN,
MUSCLE

(Drosophila
melanogaster) 		no annotation 5 GLN A 276
THR A 234
VAL A 235
ILE A 477
GLN A 474
 None
 1.12A 3elzB-5w1aA:
undetectable		 3elzB-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa0 PUTATIVE SULFITE
OXIDASE

(Sinorhizobium
meliloti) 		no annotation 5 VAL A 236
VAL A 200
ILE A 262
GLN A 263
THR A 258
 None
 1.29A 3elzB-5wa0A:
undetectable		 3elzB-5wa0A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7k LIPASE B

(Serratia
marcescens) 		no annotation 5 GLN A 413
THR A 373
VAL A 521
LEU A 522
ILE A 363
 None
 1.48A 3elzB-5x7kA:
undetectable		 3elzB-5x7kA:
22.57