SIMILAR PATTERNS OF AMINO ACIDS FOR 3ELZ_A_CHDA153_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfn KINESIN-LIKE PROTEIN
KIF22

(Homo sapiens) 		PF00225
(Kinesin) 		4 ILE A 340
THR A 136
LYS A 133
TYR A  94
 None
None
ADP  A 802 (-2.8A)
None
 1.48A 3elzA-3bfnA:
0.0		 3elzA-3bfnA:
17.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		4 ILE A  21
THR A  73
LYS A  77
TYR A  97
 CHD  A 153 ( 4.1A)
CHD  A 200 (-3.1A)
CHD  A 153 ( 4.6A)
CHD  A 153 (-4.2A)
 0.00A 3elzA-3elzA:
27.5		 3elzA-3elzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shs HOC HEAD OUTER
CAPSID PROTEIN

(Escherichia
virus RB49) 		no annotation 4 ILE A 283
THR A 223
LYS A 225
TYR A 103
 None
 1.49A 3elzA-3shsA:
1.1		 3elzA-3shsA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		4 ILE A 149
THR A 178
LYS A 181
TYR A 138
 None
 1.34A 3elzA-4iw7A:
0.0		 3elzA-4iw7A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ILE A 286
THR A 365
LYS A 361
TYR A 344
 None
 1.47A 3elzA-5j6sA:
1.7		 3elzA-5j6sA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D

(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation
no annotation 		4 ILE H 163
THR D  88
LYS D  87
TYR G 104
 None
 1.29A 3elzA-6cfwH:
0.0		 3elzA-6cfwH:
undetectable