SIMILAR PATTERNS OF AMINO ACIDS FOR 3ELZ_A_CHDA152

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00266
(Aminotran_5) 		3 VAL A 131
LYS A 132
HIS A 147
 None
 0.93A 3elzA-1bjnA:
0.0		 3elzA-1bjnA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by8 PROTEIN
(PROCATHEPSIN K)

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 VAL A  71
LYS A  74
HIS A  18
 None
 0.77A 3elzA-1by8A:
0.0		 3elzA-1by8A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases) 		3 VAL B 160
LYS B 163
HIS B 120
 None
 0.96A 3elzA-1e3dB:
0.0		 3elzA-1e3dB:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 VAL A  97
LYS A  95
HIS A 116
 None
 0.85A 3elzA-1eovA:
0.0		 3elzA-1eovA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm6 SALIVARY LIPOCALIN

(Sus scrofa) 		PF00061
(Lipocalin) 		3 VAL A  78
LYS A  77
HIS A 107
 None
 0.87A 3elzA-1gm6A:
3.1		 3elzA-1gm6A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4o PEROXIREDOXIN 5

(Homo sapiens) 		PF08534
(Redoxin) 		3 VAL A  67
LYS A  63
HIS A  51
 None
 0.93A 3elzA-1h4oA:
0.0		 3elzA-1h4oA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		3 VAL A 420
LYS A 423
HIS A 477
 None
 0.72A 3elzA-1iq0A:
0.0		 3elzA-1iq0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgs MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR

(Escherichia
coli) 		PF01047
(MarR) 		3 VAL A  21
LYS A  24
HIS A 120
 None
 0.89A 3elzA-1jgsA:
0.0		 3elzA-1jgsA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 VAL A 354
LYS A 351
HIS A 496
 None
 0.89A 3elzA-1mroA:
undetectable		 3elzA-1mroA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		3 VAL A 370
LYS A 373
HIS A 342
 None
 0.96A 3elzA-1mu2A:
undetectable		 3elzA-1mu2A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu9 STAPHYLOCOAGULASE

(Staphylococcus
aureus) 		PF08764
(Coagulase) 		3 VAL C 192
LYS C 189
HIS C 245
 None
 0.86A 3elzA-1nu9C:
undetectable		 3elzA-1nu9C:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		3 VAL A  22
LYS A  25
HIS A 346
 None
 0.95A 3elzA-1ptjA:
undetectable		 3elzA-1ptjA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp9 PEROXIREDOXIN

(Populus
trichocarpa) 		PF08534
(Redoxin) 		3 VAL A  71
LYS A  67
HIS A  55
 None
 0.91A 3elzA-1tp9A:
undetectable		 3elzA-1tp9A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v33 DNA PRIMASE SMALL
SUBUNIT

(Pyrococcus
horikoshii) 		PF01896
(DNA_primase_S) 		3 VAL A 333
LYS A 330
HIS A 298
 None
None
PO4  A 701 (-3.8A)
 0.85A 3elzA-1v33A:
undetectable		 3elzA-1v33A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woy METHIONYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF09334
(tRNA-synt_1g) 		3 VAL A 210
LYS A 207
HIS A 100
 None
 0.93A 3elzA-1woyA:
undetectable		 3elzA-1woyA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 VAL A 306
LYS A 309
HIS A 100
 None
 0.86A 3elzA-1ykwA:
undetectable		 3elzA-1ykwA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		3 VAL A  57
LYS A  60
HIS A  26
 None
 0.96A 3elzA-1z45A:
0.5		 3elzA-1z45A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		3 VAL B 434
LYS B 438
HIS B 457
 None
1PE  B5017 (-4.9A)
None
 0.95A 3elzA-2afhB:
undetectable		 3elzA-2afhB:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehh DIHYDRODIPICOLINATE
SYNTHASE

(Aquifex
aeolicus) 		PF00701
(DHDPS) 		3 VAL A 284
LYS A 287
HIS A 233
 None
 0.62A 3elzA-2ehhA:
undetectable		 3elzA-2ehhA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		3 VAL A 124
LYS A 456
HIS A 420
 None
 0.95A 3elzA-2ftwA:
undetectable		 3elzA-2ftwA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		3 VAL A 363
LYS A 368
HIS A 202
 None
 0.65A 3elzA-2gjxA:
undetectable		 3elzA-2gjxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 3 VAL I 363
LYS I 368
HIS I 202
 None
 0.70A 3elzA-2gk1I:
undetectable		 3elzA-2gk1I:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsc PUTATIVE
UNCHARACTERIZED
PROTEIN XCC0516

(Xanthomonas
campestris) 		PF05635
(23S_rRNA_IVP) 		3 VAL A 111
LYS A 114
HIS A  11
 None
 0.80A 3elzA-2gscA:
undetectable		 3elzA-2gscA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT

(Homo sapiens) 		PF10394
(Hat1_N) 		3 VAL A 229
LYS A 233
HIS A 261
 None
 0.94A 3elzA-2p0wA:
undetectable		 3elzA-2p0wA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE

(Agrobacterium
fabrum) 		PF03562
(MltA)
PF06725
(3D) 		3 VAL A 179
LYS A 178
HIS A 252
 None
 0.82A 3elzA-2pnwA:
undetectable		 3elzA-2pnwA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prx THIOESTERASE
SUPERFAMILY PROTEIN

(Shewanella
loihica) 		PF03061
(4HBT) 		3 VAL A 122
LYS A 126
HIS A  68
 None
 0.86A 3elzA-2prxA:
1.9		 3elzA-2prxA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlz TRANSCRIPTION FACTOR
PF0095

(Pyrococcus
furiosus) 		PF12840
(HTH_20) 		3 VAL A 195
LYS A 198
HIS A 171
 None
 0.76A 3elzA-2qlzA:
undetectable		 3elzA-2qlzA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA

(Aspergillus
nidulans) 		PF05368
(NmrA) 		3 VAL A 248
LYS A 247
HIS A 116
 None
 0.89A 3elzA-2vutA:
undetectable		 3elzA-2vutA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdy POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		3 VAL A 635
LYS A 638
HIS A 580
 None
SO4  A1642 ( 2.9A)
None
 0.81A 3elzA-2xdyA:
undetectable		 3elzA-2xdyA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		3 VAL A 635
LYS A 638
HIS A 580
 None
SO4  A1939 (-3.0A)
None
 0.87A 3elzA-2yhaA:
undetectable		 3elzA-2yhaA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		3 VAL A 635
LYS A 638
HIS A 580
 None
SO4  A1939 (-3.4A)
None
 0.74A 3elzA-2yhbA:
undetectable		 3elzA-2yhbA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk1 FAB FRAGMENT, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H 198
LYS H 196
HIS H 164
 None
 0.89A 3elzA-2yk1H:
undetectable		 3elzA-2yk1H:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ag6 PANTOTHENATE
SYNTHETASE

(Staphylococcus
aureus) 		PF02569
(Pantoate_ligase) 		3 VAL A 132
LYS A 135
HIS A  93
 None
 0.84A 3elzA-3ag6A:
undetectable		 3elzA-3ag6A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpo INTERLEUKIN 13

(Homo sapiens) 		PF03487
(IL13) 		3 VAL A  34
LYS A  89
HIS A  84
 VAL  A  34 ( 0.6A)
LYS  A  89 ( 0.0A)
HIS  A  84 ( 1.0A)
 0.94A 3elzA-3bpoA:
undetectable		 3elzA-3bpoA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cim CARBON
DIOXIDE-CONCENTRATIN
G MECHANISM PROTEIN
CCMK HOMOLOG 2

(Synechocystis
sp.) 		PF00936
(BMC) 		3 VAL A   5
LYS A   3
HIS A  96
 None
 0.83A 3elzA-3cimA:
undetectable		 3elzA-3cimA:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		3 VAL A  27
LYS A  30
HIS A  57
 CHD  A 152 ( 4.3A)
CHD  A 152 ( 4.1A)
CHD  A 152 (-3.7A)
 0.00A 3elzA-3elzA:
27.5		 3elzA-3elzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A 320
LYS A 346
HIS A 329
 None
 0.93A 3elzA-3fplA:
undetectable		 3elzA-3fplA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs5 UNCHARACTERIZED
PROTEIN YGR203W

(Saccharomyces
cerevisiae) 		PF00581
(Rhodanese) 		3 VAL A 138
LYS A  49
HIS A  25
 None
 0.94A 3elzA-3fs5A:
undetectable		 3elzA-3fs5A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2w SYNDAPIN

(Drosophila
melanogaster) 		PF00611
(FCH) 		3 VAL A  95
LYS A  98
HIS A 250
 None
 0.89A 3elzA-3i2wA:
undetectable		 3elzA-3i2wA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		3 VAL A 678
LYS A 715
HIS A 555
 None
 0.93A 3elzA-3i6sA:
undetectable		 3elzA-3i6sA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju7 PUTATIVE
PLP-DEPENDENT
AMINOTRANSFERASE

(Bacillus cereus) 		PF01041
(DegT_DnrJ_EryC1) 		3 VAL A 117
LYS A 121
HIS A 323
 None
 0.95A 3elzA-3ju7A:
undetectable		 3elzA-3ju7A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE

(Idiomarina
loihiensis) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		3 VAL A  34
LYS A  31
HIS A  44
 None
None
LLP  A  46 ( 3.6A)
 0.95A 3elzA-3llxA:
undetectable		 3elzA-3llxA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Burkholderia
mallei) 		PF00551
(Formyl_trans_N) 		3 VAL A 247
LYS A 221
HIS A 213
 None
 0.91A 3elzA-3louA:
undetectable		 3elzA-3louA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7m 33 KDA CHAPERONIN

(Escherichia
coli) 		PF01430
(HSP33) 		3 VAL X 163
LYS X 166
HIS X   6
 None
 0.86A 3elzA-3m7mX:
undetectable		 3elzA-3m7mX:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myo TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 1

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		3 VAL A  55
LYS A  52
HIS A  38
 None
 0.92A 3elzA-3myoA:
undetectable		 3elzA-3myoA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		3 VAL A 127
LYS A 130
HIS A 148
 None
 0.87A 3elzA-3o7wA:
undetectable		 3elzA-3o7wA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		3 VAL A 275
LYS A 272
HIS A  -1
 None
 0.88A 3elzA-3p8lA:
undetectable		 3elzA-3p8lA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkm CAS6 PROTEIN

(Pyrococcus
furiosus) 		PF01881
(Cas_Cas6) 		3 VAL A  24
LYS A  78
HIS A 210
 None
None
A  G   6 ( 3.6A)
 0.92A 3elzA-3pkmA:
undetectable		 3elzA-3pkmA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		3 VAL A 213
LYS A 216
HIS A 113
 None
 0.95A 3elzA-3qanA:
undetectable		 3elzA-3qanA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdq 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Clostridium
aminobutyricum) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 VAL A 361
LYS A 372
HIS A 201
 None
COA  A 500 (-3.3A)
None
 0.69A 3elzA-3qdqA:
undetectable		 3elzA-3qdqA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtg PYRUVATE KINASE

(Pyrobaculum
aerophilum) 		PF00224
(PK)
PF02887
(PK_C) 		3 VAL A 143
LYS A 142
HIS A 260
 None
 0.76A 3elzA-3qtgA:
undetectable		 3elzA-3qtgA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv9 PYRUVATE KINASE 2

(Trypanosoma
cruzi) 		PF00224
(PK)
PF02887
(PK_C) 		3 VAL A 153
LYS A 152
HIS A 243
 None
 0.86A 3elzA-3qv9A:
undetectable		 3elzA-3qv9A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 VAL A 111
LYS A 113
HIS A 284
 None
 0.85A 3elzA-3rw9A:
undetectable		 3elzA-3rw9A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfv LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM

(Legionella
pneumophila) 		no annotation 3 VAL B 447
LYS B 452
HIS B 469
 None
 0.82A 3elzA-3sfvB:
undetectable		 3elzA-3sfvB:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnf LIDA

(Legionella
pneumophila) 		no annotation 3 VAL B 447
LYS B 452
HIS B 469
 None
 0.86A 3elzA-3tnfB:
undetectable		 3elzA-3tnfB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP

(Staphylococcus
aureus) 		no annotation 3 VAL A  46
LYS A  48
HIS A  15
 None
 0.93A 3elzA-4ae5A:
1.2		 3elzA-4ae5A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens;
Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		3 VAL B 664
LYS B 658
HIS A 927
 None
 0.88A 3elzA-4cakB:
undetectable		 3elzA-4cakB:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 VAL A 304
LYS A 306
HIS A 385
 None
 0.82A 3elzA-4cyjA:
undetectable		 3elzA-4cyjA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dt4 FKBP-TYPE 16 KDA
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Escherichia
coli) 		PF00254
(FKBP_C) 		3 VAL A  57
LYS A  56
HIS A   0
 None
 0.96A 3elzA-4dt4A:
undetectable		 3elzA-4dt4A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM

(Legionella
pneumophila) 		no annotation 3 VAL A 447
LYS A 452
HIS A 469
 None
 0.82A 3elzA-4h5yA:
undetectable		 3elzA-4h5yA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 7

(Thermus
thermophilus) 		PF00507
(Oxidored_q4) 		3 VAL A  54
LYS A  55
HIS A  60
 None
 0.90A 3elzA-4heaA:
undetectable		 3elzA-4heaA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iop C-TYPE LECTIN DOMAIN
FAMILY 2 MEMBER A

(Homo sapiens) 		PF00059
(Lectin_C) 		3 VAL A  65
LYS A  68
HIS A 114
 None
 0.92A 3elzA-4iopA:
undetectable		 3elzA-4iopA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A  90
LYS A 151
HIS A  35
 None
 0.96A 3elzA-4jlwA:
undetectable		 3elzA-4jlwA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 VAL A 595
LYS A 581
HIS A 450
 None
 0.93A 3elzA-4k6mA:
undetectable		 3elzA-4k6mA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l59 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN 3

(Homo sapiens) 		PF02820
(MBT) 		3 VAL A 266
LYS A 265
HIS A 538
 None
 0.71A 3elzA-4l59A:
undetectable		 3elzA-4l59A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN

(Helicobacter
pylori) 		PF01497
(Peripla_BP_2) 		3 VAL A 226
LYS A 227
HIS A 103
 None
None
NI  A 603 (-3.3A)
 0.89A 3elzA-4ls3A:
undetectable		 3elzA-4ls3A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5v IRON-DEPENDENT
TRANSCRIPTION
REPRESSOR RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		3 VAL A  39
LYS A  40
HIS A  50
 None
 0.91A 3elzA-4o5vA:
undetectable		 3elzA-4o5vA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		3 VAL A 421
LYS A 419
HIS A 415
 None
 0.92A 3elzA-4oetA:
undetectable		 3elzA-4oetA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 VAL A 618
LYS A 615
HIS A 638
 None
 0.85A 3elzA-4p72A:
undetectable		 3elzA-4p72A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 VAL A 109
LYS A 112
HIS A  96
 None
None
ZN  A 301 (-3.2A)
 0.81A 3elzA-4qk3A:
1.4		 3elzA-4qk3A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r81 NADH DEHYDROGENASE

(Methanothermobacter
marburgensis) 		PF02525
(Flavodoxin_2) 		3 VAL A 163
LYS A 164
HIS A   2
 None
 0.92A 3elzA-4r81A:
undetectable		 3elzA-4r81A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uup MALATE DEHYDROGENASE

(synthetic
construct) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 VAL A 309
LYS A 312
HIS A 159
 None
 0.65A 3elzA-4uupA:
undetectable		 3elzA-4uupA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		PF00069
(Pkinase) 		3 VAL A  60
LYS A  63
HIS A 140
 None
 0.96A 3elzA-4ynzA:
undetectable		 3elzA-4ynzA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgj NITRILE HYDRATASE
BETA SUBUNIT

(Comamonas
testosteroni) 		PF02211
(NHase_beta) 		3 VAL B 127
LYS B 128
HIS B 135
 None
 0.84A 3elzA-4zgjB:
undetectable		 3elzA-4zgjB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk6 QUINOLINATE SYNTHASE
A

(Pyrococcus
horikoshii) 		PF02445
(NadA) 		3 VAL A 203
LYS A 206
HIS A 188
 None
 0.83A 3elzA-4zk6A:
undetectable		 3elzA-4zk6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztc AMINOTRANSFERASE
HOMOLOG

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		3 VAL A 249
LYS A 252
HIS A 130
 None
 0.78A 3elzA-4ztcA:
undetectable		 3elzA-4ztcA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 3 VAL A 193
LYS A 196
HIS A 302
 ST9  A 403 (-4.8A)
LMT  A 404 (-3.5A)
ZN  A 402 (-3.5A)
 0.86A 3elzA-4zyoA:
undetectable		 3elzA-4zyoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7w UPF0234 PROTEIN
XC_3703

(Xanthomonas
campestris) 		PF04461
(DUF520) 		3 VAL A  96
LYS A  45
HIS A  13
 None
 0.95A 3elzA-5b7wA:
undetectable		 3elzA-5b7wA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 3 VAL A 232
LYS A 223
HIS A 240
 None
 0.93A 3elzA-5c2vA:
0.0		 3elzA-5c2vA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs0 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		3 VAL A 999
LYS A 998
HIS A 921
 None
 0.89A 3elzA-5cs0A:
undetectable		 3elzA-5cs0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnd PUTATIVE SERINE
PROTEASE HHOA

(Synechocystis
sp. PCC 6803) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		3 VAL A 138
LYS A 136
HIS A 128
 None
 0.75A 3elzA-5gndA:
undetectable		 3elzA-5gndA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iet BACTERIAL PROTEASOME
ACTIVATOR

(Mycobacterium
tuberculosis) 		no annotation 3 VAL B  47
LYS B  46
HIS B  78
 None
 0.97A 3elzA-5ietB:
undetectable		 3elzA-5ietB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jft CASPASE 3,
APOPTOSIS-RELATED
CYSTEINE PROTEASE A

(Danio rerio) 		PF00656
(Peptidase_C14) 		3 VAL A 155
LYS A 157
HIS A 108
 None
 0.90A 3elzA-5jftA:
undetectable		 3elzA-5jftA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		3 VAL A 307
LYS A 306
HIS A 222
 None
 0.93A 3elzA-5jozA:
2.5		 3elzA-5jozA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1g 1-CYS PEROXIREDOXIN

(Vibrio
vulnificus) 		PF08534
(Redoxin) 		3 VAL A  68
LYS A  64
HIS A  52
 None
 0.92A 3elzA-5k1gA:
undetectable		 3elzA-5k1gA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfj BACTERIAL PROTEASOME
ACTIVATOR

(Mycobacterium
tuberculosis) 		PF10759
(DUF2587) 		3 VAL A  47
LYS A  46
HIS A  78
 None
 0.95A 3elzA-5lfjA:
undetectable		 3elzA-5lfjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4w CULLIN-2

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 VAL A 421
LYS A 423
HIS A 320
 None
 0.91A 3elzA-5n4wA:
undetectable		 3elzA-5n4wA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 3 VAL A 306
LYS A 305
HIS A 300
 None
 0.94A 3elzA-5n94A:
undetectable		 3elzA-5n94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878

(Staphylococcus
aureus) 		no annotation 3 VAL A  76
LYS A  73
HIS A  44
 None
 0.91A 3elzA-5na4A:
undetectable		 3elzA-5na4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nci LEUCINE HYDROXYLASE

(Streptomyces
muensis) 		PF05721
(PhyH) 		3 VAL A 137
LYS A 195
HIS A 210
 None
None
CO  A 301 ( 3.2A)
 0.83A 3elzA-5nciA:
undetectable		 3elzA-5nciA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnn CTATC

(Chaetomium
thermophilum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 VAL A2130
LYS A2129
HIS A2125
 None
None
GOL  A2301 (-3.7A)
 0.91A 3elzA-5nnnA:
undetectable		 3elzA-5nnnA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 VAL A2649
LYS A2702
HIS A2588
 None
 0.89A 3elzA-5nugA:
undetectable		 3elzA-5nugA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 VAL A 233
LYS A 226
HIS A 450
 None
 0.93A 3elzA-5nz7A:
1.6		 3elzA-5nz7A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vws CYTOCHROME P450

(Thermobispora
bispora) 		PF00067
(p450) 		3 VAL A 210
LYS A 213
HIS A  83
 None
None
HEM  A 401 (-4.0A)
 0.46A 3elzA-5vwsA:
undetectable		 3elzA-5vwsA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 3 VAL A 576
LYS A 575
HIS A 599
 None
 0.92A 3elzA-5xv7A:
undetectable		 3elzA-5xv7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y88


(;
) 		no annotation
no annotation 		3 VAL U 691
LYS U 699
HIS T 129
 None
 0.60A 3elzA-5y88U:
undetectable		 3elzA-5y88U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bck N49P7 FAB HEAVY
CHAIN OF N29P7 IGG
N49P7 FAB LIGHT
CHAIN FROM N49P7 IGG

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		3 VAL L 202
LYS L 204
HIS H 164
 None
 0.96A 3elzA-6bckL:
undetectable		 3elzA-6bckL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 3 VAL A 129
LYS A 132
HIS A 173
 None
 0.91A 3elzA-6c4gA:
undetectable		 3elzA-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv0 SPIKE GLYCOPROTEIN

(Avian
coronavirus) 		no annotation 3 VAL A 824
LYS A 827
HIS A 888
 None
 0.70A 3elzA-6cv0A:
1.3		 3elzA-6cv0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 3 VAL A 931
LYS A 936
HIS A 941
 None
 0.93A 3elzA-6en4A:
undetectable		 3elzA-6en4A:
undetectable