SIMILAR PATTERNS OF AMINO ACIDS FOR 3ELZ_A_CHDA151

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl3 PROTEIN
(PHOSPHORIBOSYLANTRA
NILATE ISOMERASE)

(Thermotoga
maritima) 		PF00697
(PRAI) 		4 ILE A  46
GLY A   8
TYR A  37
LEU A  77
 None
 0.84A 3elzA-1dl3A:
0.0		 3elzA-1dl3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE

(Methanothermobacter
thermautotrophicus) 		PF00908
(dTDP_sugar_isom) 		4 ILE A 114
GLY A 101
VAL A 131
LEU A  63
 None
 0.87A 3elzA-1epzA:
0.0		 3elzA-1epzA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8p MAGNESIUM-CHELATASE
38 KDA SUBUNIT

(Rhodobacter
capsulatus) 		PF01078
(Mg_chelatase) 		4 ILE A  26
GLY A  57
VAL A  20
LEU A  36
 None
 0.88A 3elzA-1g8pA:
undetectable		 3elzA-1g8pA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hru YRDC GENE PRODUCT

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC) 		4 TYR A  25
ILE A  61
GLY A  34
LEU A 123
 None
 0.88A 3elzA-1hruA:
0.0		 3elzA-1hruA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 TYR B 483
GLY B 455
VAL B 350
LEU B 515
 None
 0.69A 3elzA-1m2vB:
0.0		 3elzA-1m2vB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o91 COLLAGEN ALPHA
1(VIII) CHAIN

(Mus musculus) 		PF00386
(C1q) 		4 TYR A 645
GLY A 650
VAL A 623
LEU A 637
 None
 0.91A 3elzA-1o91A:
undetectable		 3elzA-1o91A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 TYR A 342
ILE A 367
GLY A 359
TYR A  62
 None
None
None
AC1  A 992 ( 3.6A)
 0.93A 3elzA-1oseA:
undetectable		 3elzA-1oseA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 TYR A 483
GLY A 455
VAL A 350
LEU A 515
 None
 0.74A 3elzA-1pd1A:
0.0		 3elzA-1pd1A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqw POLYKETIDE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00107
(ADH_zinc_N) 		4 ILE A  44
GLY A  49
TYR A  23
LEU A  82
 None
 0.73A 3elzA-1pqwA:
0.0		 3elzA-1pqwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 TYR A 407
ILE A 421
GLY A 378
LEU A 169
 None
 0.88A 3elzA-1qgdA:
undetectable		 3elzA-1qgdA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 TYR A 414
ILE A 428
GLY A 379
LEU A 171
 None
 0.87A 3elzA-1tkcA:
undetectable		 3elzA-1tkcA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbf 231AA LONG
HYPOTHETICAL
PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF01135
(PCMT) 		4 ILE A  11
GLY A  59
VAL A  23
LEU A  68
 None
 0.92A 3elzA-1vbfA:
undetectable		 3elzA-1vbfA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus) 		PF00291
(PALP) 		4 ILE A 245
GLY A 181
VAL A 199
LEU A   7
 None
PLP  A 413 (-3.2A)
None
None
 0.90A 3elzA-1ve5A:
undetectable		 3elzA-1ve5A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225

(Thermotoga
maritima) 		PF04041
(Glyco_hydro_130) 		4 ILE A  84
GLY A  34
TYR A 299
VAL A  49
 None
 0.93A 3elzA-1vkdA:
undetectable		 3elzA-1vkdA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cf5 CINNAMYL ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A  41
GLY A 133
VAL A 146
LEU A  29
ARG A  30
 None
 1.25A 3elzA-2cf5A:
undetectable		 3elzA-2cf5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxi PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 ILE A 132
GLY A 126
LEU A  80
ARG A  79
 None
 0.88A 3elzA-2hxiA:
undetectable		 3elzA-2hxiA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfq GLUTAMATE RACEMASE

(Staphylococcus
aureus) 		PF01177
(Asp_Glu_race) 		4 TYR A  32
ILE A 245
GLY A  14
TYR A  41
 None
 0.78A 3elzA-2jfqA:
undetectable		 3elzA-2jfqA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lyi PROTEIN (ENTITY)

(Nephila
antipodiana) 		PF12042
(RP1-2) 		4 ILE A  84
GLY A  42
VAL A 141
LEU A  92
 None
 0.92A 3elzA-2lyiA:
undetectable		 3elzA-2lyiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		4 ILE A 359
TYR A 445
VAL A 148
LEU A 352
 None
 0.91A 3elzA-2n0sA:
undetectable		 3elzA-2n0sA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqa LUFFACULIN 1

(Luffa
acutangula) 		PF00161
(RIP) 		4 ILE A 153
GLY A  73
TYR A 141
LEU A 113
 None
 0.92A 3elzA-2oqaA:
undetectable		 3elzA-2oqaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcu CARBOXYPEPTIDASE A4

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 ILE A 255
GLY A 252
TYR A 248
VAL A 247
ARG A 127
 None
None
None
None
ZN  A 999 (-4.5A)
 1.00A 3elzA-2pcuA:
undetectable		 3elzA-2pcuA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70

(Saccharomyces
cerevisiae) 		PF03081
(Exo70) 		4 ILE A 210
GLY A 248
TYR A 173
LEU A 272
 None
 0.74A 3elzA-2pfvA:
undetectable		 3elzA-2pfvA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy1 PECTATE LYASE II

(Xanthomonas
campestris) 		PF00544
(Pec_lyase_C) 		4 TYR A 197
ILE A 127
GLY A 176
VAL A 154
 None
 0.92A 3elzA-2qy1A:
undetectable		 3elzA-2qy1A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5v PCZA361.1

(Amycolatopsis
orientalis) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 TYR A 178
ILE A 164
GLY A 118
VAL A   9
 None
 0.89A 3elzA-2r5vA:
undetectable		 3elzA-2r5vA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei) 		PF00303
(Thymidylat_synt) 		4 ILE A  81
GLY A 225
TYR A 233
LEU A 195
 THF  A 568 ( 4.8A)
UFP  A 529 ( 4.0A)
None
THF  A 568 (-4.6A)
 0.78A 3elzA-2tddA:
undetectable		 3elzA-2tddA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbi PYRUVATE
DECARBOXYLASE

(Acetobacter
pasteurianus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 217
TYR A 261
VAL A 274
LEU A 306
 None
 0.92A 3elzA-2vbiA:
undetectable		 3elzA-2vbiA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wia FERROUS IRON
TRANSPORT PROTEIN B

(Klebsiella
pneumoniae) 		PF02421
(FeoB_N) 		4 ILE A 113
GLY A  84
TYR A 218
LEU A  57
 None
 0.90A 3elzA-2wiaA:
undetectable		 3elzA-2wiaA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 TYR A 258
GLY A 265
VAL A 304
LEU A 255
 None
 0.89A 3elzA-2yzmA:
undetectable		 3elzA-2yzmA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2

(Streptomyces
fradiae) 		PF08659
(KR) 		4 ILE A 243
GLY A 248
VAL A 440
LEU A 286
 None
 0.92A 3elzA-2z5lA:
undetectable		 3elzA-2z5lA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2n UNCHARACTERIZED
PROTEIN Q99UF4

(Staphylococcus
aureus) 		PF00072
(Response_reg) 		4 ILE A  57
GLY A  90
VAL A 100
LEU A 105
 None
 0.89A 3elzA-3b2nA:
undetectable		 3elzA-3b2nA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB) 		4 TYR A 386
ILE A 369
GLY A 390
ARG A 313
 None
 0.84A 3elzA-3ckbA:
undetectable		 3elzA-3ckbA:
13.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		5 ILE A  21
TYR A  53
VAL A  74
LEU A 123
ARG A 125
 CHD  A 153 ( 4.1A)
CHD  A 151 (-4.5A)
CHD  A 200 (-3.7A)
CHD  A 151 (-4.2A)
CHD  A 151 (-4.1A)
 1.41A 3elzA-3elzA:
27.5		 3elzA-3elzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		7 TYR A  14
ILE A  23
GLY A  31
TYR A  53
VAL A  74
LEU A 123
ARG A 125
 CHD  A 151 (-4.9A)
CHD  A 200 ( 4.7A)
CHD  A 151 (-3.6A)
CHD  A 151 (-4.5A)
CHD  A 200 (-3.7A)
CHD  A 151 (-4.2A)
CHD  A 151 (-4.1A)
 0.00A 3elzA-3elzA:
27.5		 3elzA-3elzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A 488
GLY A 494
TYR A 509
VAL A 520
 None
 0.92A 3elzA-3gbdA:
undetectable		 3elzA-3gbdA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TYR A 200
ILE A  67
GLY A  94
LEU A 162
 None
 0.88A 3elzA-3gyrA:
undetectable		 3elzA-3gyrA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		4 TYR A 302
GLY A 169
TYR A 188
ARG A 375
 ASN  A 901 (-4.6A)
ASN  A 901 (-3.8A)
None
None
 0.86A 3elzA-3h0lA:
0.0		 3elzA-3h0lA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ics COENZYME A-DISULFIDE
REDUCTASE

(Bacillus
anthracis) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 148
GLY A  51
VAL A 179
LEU A 135
 None
None
None
FAD  A 555 (-4.3A)
 0.93A 3elzA-3icsA:
undetectable		 3elzA-3icsA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Novosphingobium
aromaticivorans) 		PF00106
(adh_short) 		4 ILE A  43
GLY A  13
VAL A  79
LEU A  50
 None
 0.86A 3elzA-3ioyA:
undetectable		 3elzA-3ioyA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B

(Francisella
tularensis) 		PF05943
(VipB) 		4 ILE B 216
GLY B 206
VAL B 247
LEU B 223
 None
 0.88A 3elzA-3j9oB:
undetectable		 3elzA-3j9oB:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kae POSSIBLE PROTEIN OF
NUCLEAR SCAFFOLD

(Encephalitozoon
cuniculi) 		no annotation 4 ILE A  82
GLY A 121
LEU A  89
ARG A 139
 None
 0.88A 3elzA-3kaeA:
undetectable		 3elzA-3kaeA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 TYR E 294
GLY E 163
TYR E 182
ARG E 365
 None
 0.94A 3elzA-3kfuE:
undetectable		 3elzA-3kfuE:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg7 CURH

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		4 ILE A1135
GLY A 981
VAL A 998
LEU A 941
 None
 0.90A 3elzA-3kg7A:
2.0		 3elzA-3kg7A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kqf ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00378
(ECH_1) 		4 ILE A  88
GLY A 114
VAL A  95
LEU A  34
 None
 0.90A 3elzA-3kqfA:
undetectable		 3elzA-3kqfA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv8 THYMIDYLATE KINASE

(Vibrio cholerae) 		PF02223
(Thymidylate_kin) 		4 ILE A 113
GLY A 110
VAL A  72
ARG A 156
 None
None
TYD  A 215 (-4.1A)
None
 0.91A 3elzA-3lv8A:
undetectable		 3elzA-3lv8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 TYR A 408
ILE A 422
GLY A 378
LEU A 171
 None
 0.83A 3elzA-3m49A:
undetectable		 3elzA-3m49A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mem PUTATIVE SIGNAL
TRANSDUCTION PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF04073
(tRNA_edit)
PF08668
(HDOD) 		4 ILE A 445
GLY A 450
TYR A 230
LEU A 312
 None
 0.91A 3elzA-3memA:
undetectable		 3elzA-3memA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozq SERPIN48

(Tenebrio
molitor) 		PF00079
(Serpin) 		4 ILE A  73
GLY A  64
VAL A  90
LEU A 178
 None
 0.91A 3elzA-3ozqA:
0.9		 3elzA-3ozqA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q98 TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 TYR A  78
ILE A 372
GLY A  63
LEU A 159
 None
 0.89A 3elzA-3q98A:
undetectable		 3elzA-3q98A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe7 URACIL PERMEASE

(Escherichia
coli) 		PF00860
(Xan_ur_permease) 		4 ILE A 329
GLY A  30
VAL A 191
LEU A 322
 None
 0.81A 3elzA-3qe7A:
undetectable		 3elzA-3qe7A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5g CYAB

(Pseudomonas
aeruginosa) 		PF00211
(Guanylate_cyc) 		4 TYR A 268
ILE A 304
GLY A 416
VAL A 385
 None
 0.86A 3elzA-3r5gA:
undetectable		 3elzA-3r5gA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri) 		PF01979
(Amidohydro_1) 		4 ILE A 367
GLY A 307
VAL A 240
LEU A 375
 None
 0.93A 3elzA-3sfwA:
undetectable		 3elzA-3sfwA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgi DNA LIGASE

(Mycobacterium
tuberculosis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB) 		4 ILE A 124
GLY A 183
TYR A 253
LEU A  92
 AMP  A 616 (-4.9A)
None
None
AMP  A 616 (-4.4A)
 0.93A 3elzA-3sgiA:
undetectable		 3elzA-3sgiA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans) 		PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set) 		4 TYR A 550
GLY A 548
LEU A 520
ARG A 518
 None
 0.81A 3elzA-3utoA:
undetectable		 3elzA-3utoA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 ILE A 277
GLY A 616
VAL A 139
LEU A 591
 None
 0.72A 3elzA-3w9hA:
undetectable		 3elzA-3w9hA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROBABLE PROTEASOME
SUBUNIT ALPHA TYPE-7

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 ILE G 199
GLY G 167
VAL G  76
LEU G  52
 None
 0.92A 3elzA-3wxrG:
2.6		 3elzA-3wxrG:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		4 ILE A 113
GLY A 208
VAL A  15
LEU A 150
 None
 0.78A 3elzA-4be9A:
undetectable		 3elzA-4be9A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Neurospora
crassa) 		no annotation 4 ILE A 315
TYR A 351
VAL A 333
LEU A 432
 None
 0.93A 3elzA-4bwkA:
undetectable		 3elzA-4bwkA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		4 TYR A 389
TYR A 234
VAL A 224
LEU A 385
 None
 0.80A 3elzA-4djiA:
undetectable		 3elzA-4djiA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4er8 TNPAREP FOR PROTEIN

(Escherichia
coli) 		no annotation 4 GLY A 144
TYR A 117
VAL A 113
ARG A 139
 None
 0.82A 3elzA-4er8A:
undetectable		 3elzA-4er8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwi ABC-TYPE
DIPEPTIDE/OLIGOPEPTI
DE/NICKEL TRANSPORT
SYSTEM, ATPASE
COMPONENT

(Caldanaerobacter
subterraneus) 		PF00005
(ABC_tran)
PF08352
(oligo_HPY) 		4 ILE B  51
GLY B  46
VAL B   7
LEU B  58
 None
ATP  B 402 (-3.0A)
None
None
 0.92A 3elzA-4fwiB:
undetectable		 3elzA-4fwiB:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwi ABC-TYPE
DIPEPTIDE/OLIGOPEPTI
DE/NICKEL TRANSPORT
SYSTEM, ATPASE
COMPONENT

(Caldanaerobacter
subterraneus) 		PF00005
(ABC_tran)
PF08352
(oligo_HPY) 		4 ILE B 193
GLY B 157
VAL B  95
LEU B 142
 None
 0.68A 3elzA-4fwiB:
undetectable		 3elzA-4fwiB:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		4 ILE A  91
GLY A  63
TYR A 115
LEU A 105
 None
ACT  A 402 (-3.4A)
None
None
 0.92A 3elzA-4gc5A:
undetectable		 3elzA-4gc5A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens;
Homo sapiens) 		PF16415
(CNOT1_CAF1_bind)
PF04857
(CAF1) 		4 GLY A1300
TYR B 135
LEU A1222
ARG A1308
 None
 0.84A 3elzA-4gmjA:
undetectable		 3elzA-4gmjA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens;
Homo sapiens) 		PF16415
(CNOT1_CAF1_bind)
PF04857
(CAF1) 		4 ILE A1262
TYR B 135
LEU A1222
ARG A1308
 None
 0.85A 3elzA-4gmjA:
undetectable		 3elzA-4gmjA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 TYR A 176
GLY A 241
VAL A 267
LEU A 200
 None
 0.92A 3elzA-4h1sA:
undetectable		 3elzA-4h1sA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 TYR A 176
GLY A 241
VAL A 275
LEU A 200
 None
 0.93A 3elzA-4h1sA:
undetectable		 3elzA-4h1sA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita) 		PF00300
(His_Phos_1) 		4 ILE A 121
GLY A  94
VAL A  64
LEU A 128
 None
 0.91A 3elzA-4hbzA:
undetectable		 3elzA-4hbzA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ILE A 178
GLY A  46
VAL A 169
LEU A  26
 None
 0.86A 3elzA-4hkmA:
0.2		 3elzA-4hkmA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A 515
GLY A 521
TYR A 536
VAL A 547
 None
 0.94A 3elzA-4hozA:
2.4		 3elzA-4hozA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Yersinia pestis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ILE A 314
GLY A 308
VAL A 258
LEU A 137
 None
 0.73A 3elzA-4hv4A:
undetectable		 3elzA-4hv4A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4

(Saccharopolyspora
spinosa) 		PF08659
(KR) 		4 ILE A 186
GLY A 224
VAL A 191
LEU A 167
 None
 0.92A 3elzA-4impA:
undetectable		 3elzA-4impA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdz SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C)
PF17210
(SdrD_B) 		4 ILE A 668
GLY A 582
TYR A 610
VAL A 588
 None
 0.86A 3elzA-4jdzA:
undetectable		 3elzA-4jdzA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx6 PYRUVATE CARBOXYLASE

(Rhizobium etli) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 GLY A 843
VAL A 591
LEU A 619
ARG A 621
 None
None
KCX  A 718 (-4.8A)
PYR  A1101 (-4.0A)
 0.91A 3elzA-4jx6A:
undetectable		 3elzA-4jx6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldz TRANSCRIPTIONAL
REGULATORY PROTEIN
DESR

(Bacillus
subtilis) 		PF00072
(Response_reg)
PF00196
(GerE) 		4 ILE A  55
GLY A  86
VAL A  96
LEU A 101
 BEF  A 202 (-3.6A)
None
None
None
 0.93A 3elzA-4ldzA:
undetectable		 3elzA-4ldzA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		4 TYR A 285
GLY A 152
TYR A 171
ARG A 358
 GLN  A 501 (-4.3A)
GLN  A 501 (-3.6A)
None
None
 0.84A 3elzA-4n0iA:
undetectable		 3elzA-4n0iA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oki PHTHIOCEROL
SYNTHESIS POLYKETIDE
SYNTHASE TYPE I PPSC

(Mycobacterium
tuberculosis) 		PF00107
(ADH_zinc_N) 		4 ILE A 700
GLY A 705
TYR A 679
LEU A 738
 None
 0.76A 3elzA-4okiA:
undetectable		 3elzA-4okiA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pr3 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE

(Brucella
melitensis) 		PF01048
(PNP_UDP_1) 		4 ILE A 117
GLY A 162
TYR A  11
LEU A 205
 None
 0.93A 3elzA-4pr3A:
undetectable		 3elzA-4pr3A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q00 FERROUS IRON
TRANSPORT PROTEIN B

(Escherichia
coli) 		PF02421
(FeoB_N) 		4 ILE A 113
GLY A  84
TYR A 218
LEU A  57
 None
 0.85A 3elzA-4q00A:
undetectable		 3elzA-4q00A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzm EPOXIDE HYDROLASE
LASB

(Streptomyces
lasaliensis) 		PF12680
(SnoaL_2) 		4 GLY A 256
TYR A 269
VAL A 172
ARG A 118
 None
 0.86A 3elzA-4rzmA:
1.3		 3elzA-4rzmA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzm EPOXIDE HYDROLASE
LASB

(Streptomyces
lasaliensis) 		PF12680
(SnoaL_2) 		4 TYR A 162
TYR A 251
VAL A 215
LEU A 158
 None
LSD  A 301 ( 3.8A)
None
None
 0.87A 3elzA-4rzmA:
1.3		 3elzA-4rzmA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsh SURFACE PROTEIN
ADHESIN

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		4 TYR B1383
ILE B1334
GLY B1369
LEU B1380
 None
 0.86A 3elzA-4tshB:
undetectable		 3elzA-4tshB:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u66 PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Alkaliphilus
oremlandii) 		PF01625
(PMSR) 		4 ILE A  57
GLY A  25
TYR A 141
LEU A  78
 None
 0.84A 3elzA-4u66A:
undetectable		 3elzA-4u66A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		4 TYR A 307
GLY A 174
TYR A 193
ARG A 380
 None
 0.92A 3elzA-4wj3A:
0.5		 3elzA-4wj3A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB

(Escherichia
coli;
Staphylococcus
aureus) 		PF00717
(Peptidase_S24)
PF13416
(SBP_bac_8) 		4 TYR A 456
GLY A 413
VAL A 438
LEU A 457
 None
 0.91A 3elzA-4wviA:
undetectable		 3elzA-4wviA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 ILE A 172
TYR A 126
VAL A 105
LEU A  41
 None
 0.82A 3elzA-4xehA:
undetectable		 3elzA-4xehA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		4 ILE A  43
GLY A 113
VAL A  69
LEU A  50
 None
B12  A1101 ( 4.8A)
None
None
 0.88A 3elzA-5cjuA:
undetectable		 3elzA-5cjuA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2

(Arabidopsis
thaliana) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 ILE A 493
GLY A 353
TYR A 313
LEU A 335
 None
 0.89A 3elzA-5gxuA:
undetectable		 3elzA-5gxuA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA

(Escherichia
coli) 		PF09481
(CRISPR_Cse1) 		5 TYR A  28
ILE A  84
GLY A  55
LEU A  75
ARG A  70
 None
 1.26A 3elzA-5h9fA:
undetectable		 3elzA-5h9fA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 TYR A 411
ILE A 425
GLY A 376
LEU A 169
 None
 0.92A 3elzA-5i51A:
undetectable		 3elzA-5i51A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0t METHIONINE--TRNA
LIGASE

(Brucella suis) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 ILE A  28
GLY A  22
VAL A 331
LEU A 314
 None
 0.92A 3elzA-5k0tA:
undetectable		 3elzA-5k0tA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN
MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 TYR B 214
GLY A 437
VAL A 469
LEU A 456
 None
 0.91A 3elzA-5mkkB:
undetectable		 3elzA-5mkkB:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 4 ILE A   7
GLY A  24
VAL A  48
LEU A  79
 None
 0.92A 3elzA-5mrtA:
undetectable		 3elzA-5mrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n72 WIPA

(Legionella
pneumophila) 		no annotation 4 ILE A 208
GLY A 214
VAL A 265
LEU A 328
 None
ACT  A 504 ( 4.9A)
None
None
 0.86A 3elzA-5n72A:
undetectable		 3elzA-5n72A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0x PUTATIVE FERRIC
REDUCTASE

(Cylindrospermum
stagnale) 		PF08022
(FAD_binding_8)
PF08030
(NAD_binding_6) 		4 ILE A 477
GLY A 485
VAL A 510
LEU A 422
 None
CL  A 803 ( 4.4A)
None
None
 0.91A 3elzA-5o0xA:
undetectable		 3elzA-5o0xA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2

(Homo sapiens;
Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ILE B 414
GLY B 407
VAL A 445
LEU B 392
 None
 0.92A 3elzA-5u1dB:
undetectable		 3elzA-5u1dB:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uao TRYPTOPHANE-5-HALOGE
NASE

(Microbispora
sp. ATCC
PTA-5024) 		PF04820
(Trp_halogenase) 		4 ILE A 397
GLY A 358
TYR A  77
LEU A 390
 None
FAD  A 601 ( 3.5A)
None
None
 0.87A 3elzA-5uaoA:
1.9		 3elzA-5uaoA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42

(Saccharomyces
cerevisiae) 		no annotation 4 ILE D 174
GLY D 144
LEU D 297
ARG D 301
 None
 0.90A 3elzA-5uz5D:
undetectable		 3elzA-5uz5D:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 4 ILE A 717
GLY A 685
TYR A 815
ARG A 598
 None
 0.90A 3elzA-5v9xA:
undetectable		 3elzA-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bde 2,4-DIHYDROXYHEPT-2-
ENE-1,7-DIOIC ACID
ALDOLASE

(Kordia algicida) 		no annotation 4 ILE A   5
GLY A  71
TYR A 133
LEU A  52
 HEM  A 201 (-4.6A)
None
HEM  A 201 (-4.5A)
None
 0.81A 3elzA-6bdeA:
undetectable		 3elzA-6bdeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dcq ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		no annotation 4 ILE A 455
GLY A 473
LEU A 285
ARG A 480
 None
 0.85A 3elzA-6dcqA:
undetectable		 3elzA-6dcqA:
undetectable