SIMILAR PATTERNS OF AMINO ACIDS FOR 3ELZ_A_CHDA150

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)

(Escherichia
coli) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain) 		5 PHE B1737
THR B1663
VAL B1662
LEU B1709
TYR B1668
 None
 1.37A 3elzA-1a9xB:
undetectable		 3elzA-1a9xB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		5 PHE A 323
THR A 346
VAL A 319
LEU A  86
ILE A 316
 None
 1.34A 3elzA-1ac5A:
undetectable		 3elzA-1ac5A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5y ROB TRANSCRIPTION
FACTOR

(Escherichia
coli) 		PF06445
(GyrI-like)
PF12833
(HTH_18) 		5 THR A 184
VAL A 196
LEU A 284
ILE A 285
TYR A 244
 None
 1.38A 3elzA-1d5yA:
undetectable		 3elzA-1d5yA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pisum sativum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ASN A   7
THR A  32
VAL A 111
ILE A 126
THR A 136
 None
 1.41A 3elzA-1dxlA:
undetectable		 3elzA-1dxlA:
15.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eio ILEAL LIPID BINDING
PROTEIN

(Sus scrofa) 		PF14651
(Lipocalin_7) 		5 TRP A  49
ASN A  61
PHE A  63
VAL A  83
TYR A  97
 GCH  A 128 ( 2.8A)
GCH  A 128 (-2.8A)
GCH  A 128 ( 4.2A)
None
GCH  A 128 (-3.1A)
 0.81A 3elzA-1eioA:
15.2		 3elzA-1eioA:
49.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gw1 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		5 PHE A 356
MET A  65
VAL A 107
ILE A 137
TYR A 415
 None
 1.42A 3elzA-1gw1A:
undetectable		 3elzA-1gw1A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5y HISF

(Pyrobaculum
aerophilum) 		PF00977
(His_biosynth) 		5 PHE A 213
VAL A 240
LEU A 235
ILE A 237
TYR A  42
 None
 1.36A 3elzA-1h5yA:
undetectable		 3elzA-1h5yA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 ASN A 418
THR A 450
VAL A 383
LEU A 442
TYR A 522
 None
 1.10A 3elzA-1j0hA:
0.0		 3elzA-1j0hA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k94 GRANCALCIN

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13833
(EF-hand_8) 		5 ASN A  83
PHE A  89
THR A  85
VAL A 179
LEU A 121
 None
 1.30A 3elzA-1k94A:
undetectable		 3elzA-1k94A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 ASN E 145
VAL E 119
LEU E 115
ILE E 120
THR E 113
 None
 1.06A 3elzA-1nfiE:
undetectable		 3elzA-1nfiE:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1u GASTROTROPIN

(Homo sapiens) 		PF14651
(Lipocalin_7) 		5 TRP A  49
ASN A  61
PHE A  63
VAL A  83
LEU A  90
 None
 0.73A 3elzA-1o1uA:
16.2		 3elzA-1o1uA:
56.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1u GASTROTROPIN

(Homo sapiens) 		PF14651
(Lipocalin_7) 		6 TRP A  49
GLN A  51
PHE A  63
VAL A  83
LEU A  90
TYR A  97
 None
 0.87A 3elzA-1o1uA:
16.2		 3elzA-1o1uA:
56.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogp SULFITE OXIDASE

(Arabidopsis
thaliana) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 PHE A 204
VAL A 219
VAL A  59
LEU A  62
ILE A   4
 None
MTQ  A1394 (-3.8A)
None
None
None
 1.36A 3elzA-1ogpA:
undetectable		 3elzA-1ogpA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p5v F1 CAPSULE ANTIGEN

(Yersinia pestis) 		PF09255
(Antig_Caf1) 		5 PHE B  62
THR B  56
VAL B 113
VAL B 144
LEU B  21
 None
 1.04A 3elzA-1p5vB:
undetectable		 3elzA-1p5vB:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3t CYTIDYLATE KINASE

(Streptococcus
pneumoniae) 		PF02224
(Cytidylate_kin) 		5 MET A  57
THR A  55
VAL A 112
VAL A  97
ILE A  99
 None
 1.36A 3elzA-1q3tA:
undetectable		 3elzA-1q3tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ro5 AUTOINDUCER
SYNTHESIS PROTEIN
LASI

(Pseudomonas
aeruginosa) 		PF00765
(Autoind_synth) 		5 ASN A 181
VAL A 159
VAL A 192
LEU A 193
ILE A 186
 None
 1.40A 3elzA-1ro5A:
undetectable		 3elzA-1ro5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuo PUTATIVE
PHOSPHOMANNOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 PHE A 370
VAL A 255
VAL A 373
LEU A 296
THR A 294
 None
 1.25A 3elzA-1tuoA:
undetectable		 3elzA-1tuoA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 336
VAL A 180
LEU A 242
ILE A 191
THR A 163
 None
 1.27A 3elzA-1uufA:
undetectable		 3elzA-1uufA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		5 ASN A  73
THR A 107
VAL A 110
LEU A  87
ILE A  91
 None
 1.23A 3elzA-1z6tA:
undetectable		 3elzA-1z6tA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zaw 50S RIBOSOMAL
PROTEIN L10

(Thermotoga
maritima) 		PF00466
(Ribosomal_L10) 		5 VAL A   0
VAL A  11
LEU A  64
ILE A  10
THR A  60
 None
 1.33A 3elzA-1zawA:
undetectable		 3elzA-1zawA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 ASN A 292
THR A 432
VAL A 433
VAL A 406
LEU A 407
 None
 1.32A 3elzA-1zkcA:
undetectable		 3elzA-1zkcA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)

(Homo sapiens) 		PF03051
(Peptidase_C1_2) 		5 PHE A 415
THR A 377
VAL A  57
VAL A 419
LEU A 308
 None
 1.33A 3elzA-2cb5A:
undetectable		 3elzA-2cb5A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7y TRNASE Z

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		5 TRP A  14
VAL A  51
VAL A  38
LEU A  34
THR A  33
 PGO  A 601 (-3.8A)
None
None
None
PGO  A 601 (-3.8A)
 1.20A 3elzA-2e7yA:
undetectable		 3elzA-2e7yA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f73 FATTY ACID-BINDING
PROTEIN, LIVER

(Homo sapiens) 		PF14651
(Lipocalin_7) 		6 ASN A  61
PHE A  63
THR A  73
VAL A  83
LEU A  91
THR A 102
 None
 0.75A 3elzA-2f73A:
17.2		 3elzA-2f73A:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 THR A 154
VAL A 153
VAL A 338
ILE A 339
THR A 356
 None
 1.39A 3elzA-2f9qA:
undetectable		 3elzA-2f9qA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7c TOXIN A

(Clostridioides
difficile) 		PF01473
(CW_binding_1) 		5 PHE A 241
MET A 229
THR A 216
VAL A 215
ILE A 243
 None
 1.39A 3elzA-2g7cA:
undetectable		 3elzA-2g7cA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghi TRANSPORT PROTEIN

(Plasmodium
yoelii) 		PF00005
(ABC_tran) 		5 GLN A  30
VAL A  23
LEU A  65
ILE A  39
THR A  61
 SO4  A2003 (-4.9A)
None
None
None
None
 1.40A 3elzA-2ghiA:
undetectable		 3elzA-2ghiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwg 4-OXALOMESACONATE
HYDRATASE

(Rhodopseudomonas
palustris) 		PF04909
(Amidohydro_2) 		5 GLN A 264
THR A 303
VAL A 276
ILE A 321
TYR A 322
 None
 1.30A 3elzA-2gwgA:
undetectable		 3elzA-2gwgA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hig 6-PHOSPHO-1-FRUCTOKI
NASE

(Trypanosoma
brucei) 		PF00365
(PFK) 		5 GLN A 202
PHE A 239
VAL A 115
LEU A 112
THR A 104
 None
 1.29A 3elzA-2higA:
undetectable		 3elzA-2higA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j71 PULLULANASE

(Thermotoga
maritima) 		PF03714
(PUD) 		5 VAL A  51
VAL A  63
LEU A  60
ILE A  83
THR A   7
 None
 1.38A 3elzA-2j71A:
undetectable		 3elzA-2j71A:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lba BABP PROTEIN

(Gallus gallus) 		PF14651
(Lipocalin_7) 		8 TRP A  49
GLN A  51
ASN A  61
PHE A  63
MET A  71
THR A  73
VAL A  83
TYR A  97
 CHO  A 201 (-2.9A)
CHO  A 201 ( 3.4A)
CHO  A 201 ( 3.5A)
CHO  A 201 (-3.1A)
CHO  A 201 (-2.4A)
CHO  A 201 (-2.8A)
CHO  A 201 ( 4.0A)
CHO  A 201 (-2.6A)
 1.05A 3elzA-2lbaA:
19.5		 3elzA-2lbaA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lkk FATTY ACID-BINDING
PROTEIN, LIVER

(Homo sapiens) 		PF14651
(Lipocalin_7) 		5 PHE A  63
THR A  73
VAL A  83
LEU A  91
THR A 102
 OLA  A 129 ( 3.9A)
None
None
None
OLA  A 129 (-2.7A)
 0.78A 3elzA-2lkkA:
16.2		 3elzA-2lkkA:
40.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8s AGR_C_984P

(Agrobacterium
fabrum) 		PF06748
(DUF1217) 		5 TRP A 273
PHE A 269
THR A  55
VAL A  54
LEU A 198
 None
 1.10A 3elzA-2o8sA:
undetectable		 3elzA-2o8sA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qj6 TOXIN A

(Clostridioides
difficile) 		PF01473
(CW_binding_1) 		5 PHE A 315
MET A 303
THR A 290
VAL A 289
ILE A 317
 PHE  A 315 ( 1.3A)
MET  A 303 ( 0.0A)
THR  A 290 ( 0.8A)
VAL  A 289 ( 0.6A)
ILE  A 317 ( 0.6A)
 1.40A 3elzA-2qj6A:
undetectable		 3elzA-2qj6A:
18.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		5 ASN A  60
PHE A  62
THR A  72
VAL A  82
LEU A  89
 IPA  A 141 ( 4.7A)
IPA  A 142 ( 4.4A)
GOL  A 145 (-3.2A)
None
IPA  A 142 ( 4.7A)
 0.73A 3elzA-2qo4A:
20.3		 3elzA-2qo4A:
45.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq1 MOLYBDENUM COFACTOR
BIOSYNTHESIS MOG

(Aquifex
aeolicus) 		PF00994
(MoCF_biosynth) 		5 PHE A 101
MET A 105
VAL A 132
LEU A 130
TYR A  33
 None
 1.26A 3elzA-2qq1A:
undetectable		 3elzA-2qq1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtp UNCHARACTERIZED
PROTEIN

(Ruegeria
pomeroyi) 		PF06684
(AA_synth) 		5 ASN A  37
VAL A  44
VAL A 164
LEU A  57
THR A  53
 None
 1.43A 3elzA-2qtpA:
undetectable		 3elzA-2qtpA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r94 2-KETO-3-DEOXY-(6-PH
OSPHO-)GLUCONATE
ALDOLASE

(Thermoproteus
tenax) 		PF00701
(DHDPS) 		5 ASN A  47
THR A  49
VAL A  53
LEU A  40
THR A  30
 None
 1.30A 3elzA-2r94A:
undetectable		 3elzA-2r94A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wql MAJOR ALLERGEN DAU C
1

(Daucus carota) 		PF00407
(Bet_v_1) 		5 PHE A  20
MET A 102
THR A 100
LEU A  25
ILE A  23
 None
P4C  A 200 ( 4.0A)
P4C  A 200 ( 4.1A)
None
P4C  A 200 (-4.3A)
 1.43A 3elzA-2wqlA:
1.7		 3elzA-2wqlA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		5 THR A 263
VAL A  46
VAL A  74
LEU A 193
THR A 194
 None
 1.39A 3elzA-2wyxA:
undetectable		 3elzA-2wyxA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 VAL A 725
VAL A 545
LEU A 599
ILE A 549
TYR A 586
 None
 1.40A 3elzA-2xt6A:
undetectable		 3elzA-2xt6A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		5 PHE B 333
VAL B 264
VAL B 337
LEU B 367
ILE B 340
 None
 1.40A 3elzA-2xwuB:
undetectable		 3elzA-2xwuB:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG

(Mycobacterium
tuberculosis) 		PF01474
(DAHP_synth_2) 		5 THR A  59
VAL A  60
VAL A 103
LEU A 186
ILE A 243
 None
 1.33A 3elzA-2ypqA:
undetectable		 3elzA-2ypqA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj9 AMPC

(Escherichia
coli) 		PF00144
(Beta-lactamase) 		5 PHE A  69
MET A 174
THR A 176
VAL A 223
ILE A 189
 None
 1.30A 3elzA-2zj9A:
undetectable		 3elzA-2zj9A:
15.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elz ILEAL BILE
ACID-BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		12 TRP A  49
GLN A  51
ASN A  61
PHE A  63
MET A  71
THR A  73
VAL A  74
VAL A  83
LEU A  90
ILE A  92
TYR A  97
THR A 101
 CHD  A 150 (-3.5A)
CHD  A 150 ( 3.7A)
CHD  A 150 ( 4.0A)
CHD  A 150 (-4.1A)
CHD  A 150 ( 3.7A)
CHD  A 200 (-3.1A)
CHD  A 200 (-3.7A)
CHD  A 150 (-4.4A)
CHD  A 150 (-4.4A)
CHD  A 150 (-3.9A)
CHD  A 153 (-4.2A)
CHD  A 150 (-2.9A)
 0.00A 3elzA-3elzA:
27.5		 3elzA-3elzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD) 		5 GLN B 119
PHE B 273
THR B 142
VAL B 240
LEU B 271
 None
 1.35A 3elzA-3fhcB:
undetectable		 3elzA-3fhcB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1

(Thermus
thermophilus) 		PF02074
(Peptidase_M32) 		5 ASN A 367
PHE A 185
THR A 365
LEU A 374
TYR A 398
 None
 1.39A 3elzA-3hoaA:
undetectable		 3elzA-3hoaA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 PHE A 185
THR A  62
VAL A 187
LEU A 363
THR A 370
 None
 1.38A 3elzA-3ifeA:
undetectable		 3elzA-3ifeA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izk CHAPERONIN

(Methanococcus
maripaludis) 		PF00118
(Cpn60_TCP1) 		5 ASN A 419
THR A  32
VAL A  29
VAL A 447
LEU A 445
 None
 1.10A 3elzA-3izkA:
undetectable		 3elzA-3izkA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		5 GLN A 478
PHE A 470
THR A 610
VAL A 519
THR A 492
 None
 1.16A 3elzA-3k8kA:
undetectable		 3elzA-3k8kA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		5 PHE A 688
THR A 522
VAL A 519
VAL A 660
THR A 667
 None
 1.31A 3elzA-3k8kA:
undetectable		 3elzA-3k8kA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		5 PHE A 688
VAL A 519
VAL A 660
LEU A  47
THR A 667
 None
 1.15A 3elzA-3k8kA:
undetectable		 3elzA-3k8kA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd4 PUTATIVE PROTEASE

(Parabacteroides
distasonis) 		PF12969
(DUF3857)
PF12970
(DUF3858) 		5 THR A 354
VAL A 355
VAL A 376
ILE A 384
THR A 368
 None
 1.11A 3elzA-3kd4A:
undetectable		 3elzA-3kd4A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldh LACTATE
DEHYDROGENASE

(Squalus
acanthias) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLN A 314
VAL A 285
LEU A 322
ILE A 281
THR A 321
 None
 1.33A 3elzA-3ldhA:
undetectable		 3elzA-3ldhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqj MLL1 PHD3-BROMO

(Homo sapiens) 		PF00628
(PHD) 		5 PHE A1769
MET A1762
VAL A1754
VAL A1723
LEU A1724
 None
 1.16A 3elzA-3lqjA:
undetectable		 3elzA-3lqjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		5 GLN A 298
MET A  59
LEU A  83
ILE A  87
THR A  72
 None
 1.28A 3elzA-3mmtA:
undetectable		 3elzA-3mmtA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 ASN B 472
PHE A 243
VAL A 257
LEU A 227
ILE A 241
 None
 1.41A 3elzA-3pcoB:
undetectable		 3elzA-3pcoB:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
phage 201phi2-1) 		PF00091
(Tubulin) 		5 PHE A   9
VAL A 149
VAL A  17
LEU A  21
ILE A 168
 None
 1.14A 3elzA-3r4vA:
undetectable		 3elzA-3r4vA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 PHE A1071
THR A1150
VAL A1073
LEU A1214
THR A1080
 None
 1.12A 3elzA-3va7A:
undetectable		 3elzA-3va7A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 THR A  60
VAL A 129
LEU A 127
ILE A 142
TYR A 155
 None
 1.41A 3elzA-3wfaA:
undetectable		 3elzA-3wfaA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 VAL A 725
VAL A 545
LEU A 599
ILE A 549
TYR A 586
 None
 1.41A 3elzA-3zhrA:
undetectable		 3elzA-3zhrA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zny CTX-M-12A ENZYME

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		5 THR A 263
VAL A  46
VAL A  74
LEU A 193
THR A 194
 None
 1.40A 3elzA-3znyA:
0.5		 3elzA-3znyA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		5 PHE A 113
THR A 128
VAL A 127
VAL A 183
ILE A 173
 None
 1.13A 3elzA-3zs6A:
undetectable		 3elzA-3zs6A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE

(Neurospora
sitophila) 		PF00150
(Cellulase) 		5 PHE A 103
MET A 163
THR A 165
VAL A 119
LEU A 117
 None
 1.34A 3elzA-4aweA:
undetectable		 3elzA-4aweA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfc 3-DEOXY-D-MANNO-OCTU
LOSONIC-ACID
TRANSFERASE

(Acinetobacter
baumannii) 		no annotation 5 VAL A 384
VAL A 282
LEU A 310
ILE A 285
THR A 293
 None
 1.41A 3elzA-4bfcA:
undetectable		 3elzA-4bfcA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
CNRY

(Cupriavidus
metallidurans;
Cupriavidus
metallidurans) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2)
PF17524
(CnrY) 		5 PHE A  40
VAL B  22
VAL A 147
LEU A 148
ILE A 151
 None
 1.30A 3elzA-4cxfA:
undetectable		 3elzA-4cxfA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		5 PHE A 311
VAL A 127
VAL A 112
LEU A 107
THR A 105
 None
 1.36A 3elzA-4dwqA:
0.4		 3elzA-4dwqA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ees PHOTOTROPIN-2

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		5 THR A 453
VAL A 454
VAL A 475
ILE A 486
THR A 394
 None
None
None
None
FMN  A1001 (-3.3A)
 1.33A 3elzA-4eesA:
undetectable		 3elzA-4eesA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		5 TRP A  42
PHE A  27
VAL A  48
VAL A  78
LEU A 250
 None
 1.19A 3elzA-4euoA:
undetectable		 3elzA-4euoA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f47 ENOYL-COA HYDRATASE
ECHA19

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 PHE A  73
MET A  31
VAL A  20
LEU A 130
THR A 133
 None
 1.28A 3elzA-4f47A:
undetectable		 3elzA-4f47A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF07523
(Big_3)
PF13306
(LRR_5) 		5 PHE A 294
VAL A 228
VAL A 280
LEU A 282
ILE A 258
 None
 1.42A 3elzA-4fd0A:
undetectable		 3elzA-4fd0A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		5 PHE A 589
VAL A 645
LEU A 647
ILE A 626
TYR A 611
 None
 1.36A 3elzA-4fwtA:
undetectable		 3elzA-4fwtA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA

(Rattus
norvegicus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 PHE A1004
VAL A 266
VAL A1071
ILE A1100
TYR A1088
 None
 1.25A 3elzA-4grvA:
undetectable		 3elzA-4grvA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7n ALDEHYDE
DEHYDROGENASE

(Trichormus
variabilis) 		PF00171
(Aldedh) 		5 ASN A  73
VAL A   7
VAL A 297
LEU A  78
THR A  81
 None
 1.36A 3elzA-4h7nA:
undetectable		 3elzA-4h7nA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		5 PHE A 264
THR A 256
VAL A 253
VAL A 293
LEU A 294
 None
 1.28A 3elzA-4i2wA:
undetectable		 3elzA-4i2wA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 PHE A 294
THR A 340
VAL A 290
LEU A 349
ILE A 325
 None
 1.27A 3elzA-4jclA:
undetectable		 3elzA-4jclA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbx TCDA

(Clostridioides
difficile) 		PF01473
(CW_binding_1) 		5 PHE A 123
MET A 111
THR A  98
VAL A  97
ILE A 125
 None
 1.38A 3elzA-4nbxA:
undetectable		 3elzA-4nbxA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9t NUCLEOPORIN NUP133

(Vanderwaltozyma
polyspora) 		PF08801
(Nucleoporin_N) 		5 ASN A 439
PHE A 437
VAL A 442
LEU A 400
ILE A 463
 None
 1.33A 3elzA-4q9tA:
undetectable		 3elzA-4q9tA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 5 THR A 413
VAL A 414
VAL A 399
ILE A 395
TYR A 391
 None
 1.14A 3elzA-4qnlA:
undetectable		 3elzA-4qnlA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		5 TRP A 209
GLN A 180
THR A  82
VAL A  81
ILE A  86
 None
 1.24A 3elzA-4r9oA:
undetectable		 3elzA-4r9oA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)

(Agrobacterium
fabrum) 		PF01547
(SBP_bac_1) 		5 TRP A 204
PHE A 189
THR A 198
LEU A 230
THR A 226
 None
 1.34A 3elzA-4rjzA:
undetectable		 3elzA-4rjzA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlq BENZOATE-COENZYME A
LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ASN A 232
VAL A 271
LEU A 332
ILE A 334
THR A 201
 None
 1.34A 3elzA-4rlqA:
undetectable		 3elzA-4rlqA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmt UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		no annotation 5 ASN A  76
VAL A  58
LEU A  56
ILE A  61
TYR A  67
 None
 1.31A 3elzA-5bmtA:
undetectable		 3elzA-5bmtA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9l PLL LECTIN

(Photorhabdus
luminescens) 		PF03984
(DUF346) 		5 GLN A 211
PHE A 186
VAL A 233
LEU A 231
ILE A 245
 None
 1.21A 3elzA-5c9lA:
2.0		 3elzA-5c9lA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzz DESMOPLAKIN

(Homo sapiens) 		PF00681
(Plectin) 		5 PHE A2096
VAL A2107
LEU A2124
ILE A2111
THR A2120
 None
 1.40A 3elzA-5dzzA:
undetectable		 3elzA-5dzzA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7g IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		no annotation 5 THR A 350
VAL A 337
VAL A 318
LEU A 315
ILE A 325
 None
 1.28A 3elzA-5e7gA:
undetectable		 3elzA-5e7gA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG

(Caenorhabditis
elegans) 		PF03159
(XRN_N) 		5 PHE A 249
THR A  17
VAL A  18
LEU A 240
ILE A 242
 None
 1.06A 3elzA-5firA:
undetectable		 3elzA-5firA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftx SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 5 THR A 542
VAL A 541
VAL A 547
LEU A 454
ILE A 545
 None
 1.39A 3elzA-5ftxA:
undetectable		 3elzA-5ftxA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 PHE A1071
THR A1150
VAL A1073
LEU A1214
THR A1080
 None
 1.11A 3elzA-5i8iA:
undetectable		 3elzA-5i8iA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j98 VP3

(Slow bee
paralysis virus) 		PF00073
(Rhv) 		5 THR C 108
VAL C 101
ILE C 319
TYR C 350
THR C 324
 None
 1.43A 3elzA-5j98C:
undetectable		 3elzA-5j98C:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lac 3CL PROTEASE

(Alphamesonivirus
1) 		PF17222
(Peptidase_C107) 		5 MET A 156
THR A 117
VAL A 116
VAL A  39
ILE A 103
 None
 1.41A 3elzA-5lacA:
undetectable		 3elzA-5lacA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 5 GLN A 413
THR A 538
VAL A 537
LEU A 149
ILE A 147
 None
 1.24A 3elzA-5m6gA:
undetectable		 3elzA-5m6gA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 5 THR A 538
VAL A 537
LEU A 149
ILE A 147
THR A 152
 None
 1.25A 3elzA-5m6gA:
undetectable		 3elzA-5m6gA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 ASN A 151
VAL A 261
VAL A 181
LEU A 175
THR A 172
 None
FAD  A2001 (-4.5A)
None
None
None
 1.19A 3elzA-5ux5A:
undetectable		 3elzA-5ux5A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE

(Trypanosoma
brucei) 		PF00156
(Pribosyltran) 		5 THR A 202
VAL A 201
VAL A  45
LEU A  85
ILE A  48
 None
 1.41A 3elzA-5vn4A:
undetectable		 3elzA-5vn4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		5 ASN A 413
THR A 198
VAL A 313
ILE A 312
THR A 272
 None
None
None
HEM  A 502 (-3.7A)
None
 1.04A 3elzA-5xjnA:
undetectable		 3elzA-5xjnA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bu3 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 THR A 263
VAL A  46
VAL A  74
LEU A 193
THR A 194
 None
 1.42A 3elzA-6bu3A:
undetectable		 3elzA-6bu3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Homo sapiens) 		no annotation 5 PHE B 101
VAL B 198
VAL B 135
LEU B 133
ILE B  62
 None
 0.69A 3elzA-6d6uB:
undetectable		 3elzA-6d6uB:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 5 PHE D 331
MET D  89
VAL D 621
LEU D 619
THR D 632
 None
 1.35A 3elzA-6eq8D:
undetectable		 3elzA-6eq8D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gkv COCLAURINE
N-METHYLTRANSFERASE

(Coptis japonica) 		no annotation 5 TRP A 329
MET A 311
VAL A 323
LEU A  88
ILE A  90
 None
 1.37A 3elzA-6gkvA:
undetectable		 3elzA-6gkvA:
undetectable