SIMILAR PATTERNS OF AMINO ACIDS FOR 3EL0_A_1UNA201_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b9b | PROTEIN(TRIOSEPHOSPHATEISOMERASE) (Thermotogamaritima) |
PF00121(TIM) | 5 | LEU A 31VAL A 40GLY A 231ILE A 224ILE A 39 | None | 0.95A | 3el0B-1b9bA:undetectable | 3el0B-1b9bA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bdb | CIS-BIPHENYL-2,3-DIHYDRODIOL-2,3-DEHYDROGENASE (Pseudomonas sp.) |
PF00106(adh_short) | 5 | LEU A 165GLY A 88ILE A 114ALA A 161ILE A 162 | NoneNAD A 300 ( 3.9A)NAD A 300 ( 4.3A)NoneNone | 1.05A | 3el0B-1bdbA:undetectable | 3el0B-1bdbA:16.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bry | BRYODIN I (Bryonia dioica) |
PF00161(RIP) | 5 | LEU Y 49VAL Y 66ILE Y 41GLY Y 43ALA Y 63 | None | 1.03A | 3el0B-1bryY:undetectable | 3el0B-1bryY:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d6h | CHALCONE SYNTHASE (Medicago sativa) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 6 | LEU A 283VAL A 275ILE A 309ILE A 301ALA A 282ILE A 279 | None | 1.38A | 3el0B-1d6hA:undetectable | 3el0B-1d6hA:14.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dqs | PROTEIN(3-DEHYDROQUINATESYNTHASE) (Aspergillusnidulans) |
PF01761(DHQ_synthase) | 5 | LEU A 263ILE A 167GLY A 150ILE A 149ALA A 256 | None | 0.75A | 3el0B-1dqsA:undetectable | 3el0B-1dqsA:14.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e5m | BETA KETOACYL ACYLCARRIER PROTEINSYNTHASE II (Synechocystissp. PCC 6803) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 6 | LEU A 94VAL A 11GLY A 192ILE A 108ALA A 188ILE A 243 | None | 1.25A | 3el0B-1e5mA:undetectable | 3el0B-1e5mA:13.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fuj | PR3 (Homo sapiens) |
PF00089(Trypsin) | 5 | VAL A 121ILE A 200GLY A 211PRO A 124ILE A 47 | NoneFUC A 245 (-4.3A)NoneNoneNone | 0.93A | 3el0B-1fujA:undetectable | 3el0B-1fujA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gm5 | RECG (Thermotogamaritima) |
PF00270(DEAD)PF00271(Helicase_C)PF17190(RecG_N)PF17191(RecG_wedge) | 5 | LEU A 201VAL A 227ILE A 156ALA A 241ILE A 238 | None | 0.93A | 3el0B-1gm5A:undetectable | 3el0B-1gm5A:8.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gy8 | UDP-GALACTOSE4-EPIMERASE (Trypanosomabrucei) |
PF01370(Epimerase) | 5 | ILE A 193GLY A 195ILE A 196ALA A 180ILE A 122 | None | 1.05A | 3el0B-1gy8A:undetectable | 3el0B-1gy8A:13.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ASP A 25VAL A 32ILE A 47GLY A 49ILE A 50ILE A 84 | A79 A 800 ( 3.8A)A79 A 800 (-2.7A)A79 A 800 ( 4.4A)A79 A 800 ( 3.2A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 (-3.6A) | 0.59A | 3el0B-1hvcA:14.1 | 3el0B-1hvcA:46.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 ( 4.0A)A79 A 800 (-2.8A)A79 A 800 ( 4.3A)A79 A 800 ( 3.4A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-3.8A) | 0.60A | 3el0B-1hvcA:14.1 | 3el0B-1hvcA:46.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ASP A 25VAL A 32ILE A 47ILE A 50PRO A 81ILE A 84 | A79 A 800 ( 3.8A)A79 A 800 (-2.7A)A79 A 800 ( 4.4A)A79 A 800 ( 3.2A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-3.6A) | 0.78A | 3el0B-1hvcA:14.1 | 3el0B-1hvcA:46.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kbz | DTDP-GLUCOSEOXIDOREDUCTASE (Salmonellaenterica) |
PF04321(RmlD_sub_bind) | 5 | VAL A 57ILE A 200ILE A 148ALA A 92ILE A 58 | None | 1.03A | 3el0B-1kbzA:undetectable | 3el0B-1kbzA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lxy | ARGININE DEIMINASE (Mycoplasmaarginini) |
PF02274(Amidinotransf) | 5 | LEU A 65GLY A 18ILE A 17PRO A 402ILE A 70 | None | 1.01A | 3el0B-1lxyA:undetectable | 3el0B-1lxyA:14.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nvm | ACETALDEHYDEDEHYDROGENASE(ACYLATING) (Pseudomonas sp.CF600) |
PF01118(Semialdhyde_dh)PF09290(AcetDehyd-dimer) | 5 | VAL B 211GLY B 187ILE B 186ALA B 136ILE B 155 | None | 1.01A | 3el0B-1nvmB:undetectable | 3el0B-1nvmB:16.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 6 | LEU A 23ASP A 25GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.77A | 3el0B-1sivA:18.3 | 3el0B-1sivA:48.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tz7 | 4-ALPHA-GLUCANOTRANSFERASE (Aquifexaeolicus) |
PF02446(Glyco_hydro_77) | 5 | VAL A 378ILE A 331ILE A 203ALA A 4ILE A 434 | None | 1.04A | 3el0B-1tz7A:undetectable | 3el0B-1tz7A:10.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1woq | INORGANICPOLYPHOSPHATE/ATP-GLUCOMANNOKINASE (Arthrobactersp. KM) |
PF00480(ROK) | 5 | LEU A 163VAL A 144GLY A 135ALA A 156ILE A 158 | None | 0.79A | 3el0B-1woqA:undetectable | 3el0B-1woqA:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xfk | FORMIMIDOYLGLUTAMASE (Vibrio cholerae) |
PF00491(Arginase) | 5 | LEU A 90VAL A 122GLY A 136ALA A 46ILE A 48 | None | 0.99A | 3el0B-1xfkA:undetectable | 3el0B-1xfkA:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bb0 | IMIDAZOLONEPROPIONASE (Bacillussubtilis) |
PF01979(Amidohydro_1) | 6 | LEU A 374VAL A 48ILE A 5ILE A 10ALA A 50ILE A 47 | None | 1.27A | 3el0B-2bb0A:undetectable | 3el0B-2bb0A:12.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bb0 | IMIDAZOLONEPROPIONASE (Bacillussubtilis) |
PF01979(Amidohydro_1) | 6 | LEU A 374VAL A 48ILE A 5ILE A 65ALA A 50ILE A 47 | None | 1.08A | 3el0B-2bb0A:undetectable | 3el0B-2bb0A:12.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cg8 | DIHYDRONEOPTERINALDOLASE6-HYDROXYMETHYL-7,8-DIHYDROPTERINSYNTHASE (Streptococcuspneumoniae) |
PF01288(HPPK)PF02152(FolB) | 5 | LEU A 215VAL A 176ILE A 141ALA A 122ILE A 124 | None | 0.96A | 3el0B-2cg8A:undetectable | 3el0B-2cg8A:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cl2 | PUTATIVELAMINARINASE (Phanerochaetechrysosporium) |
no annotation | 5 | LEU A 52VAL A 89ILE A 119ILE A 248ILE A 291 | None | 1.04A | 3el0B-2cl2A:undetectable | 3el0B-2cl2A:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fb5 | HYPOTHETICALMEMBRANE SPANNINGPROTEIN (Bacillus cereus) |
PF02457(DisA_N)PF10372(YojJ) | 5 | LEU A 114VAL A 140ILE A 80ALA A 148ILE A 145 | None | 0.93A | 3el0B-2fb5A:undetectable | 3el0B-2fb5A:19.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 7 | LEU A 23ASP A 25VAL A 32ILE A 53GLY A 55PRO A 86ILE A 89 | NoneLP1 A 201 (-2.3A)NoneLP1 A 201 (-4.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 (-4.2A) | 0.71A | 3el0B-2fmbA:14.7 | 3el0B-2fmbA:31.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2izo | FLAPSTRUCTURE-SPECIFICENDONUCLEASE (Sulfolobussolfataricus) |
PF00752(XPG_N)PF00867(XPG_I) | 6 | LEU A 181ILE A 224GLY A 227ILE A 230ALA A 173ILE A 174 | None | 1.43A | 3el0B-2izoA:undetectable | 3el0B-2izoA:14.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nzo | PROTEIN CSAA (Bacillussubtilis) |
PF01588(tRNA_bind) | 5 | LEU A 59VAL A 18ILE A 43ALA A 20ILE A 17 | None | 0.97A | 3el0B-2nzoA:undetectable | 3el0B-2nzoA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p7j | PUTATIVE SENSORYBOX/GGDEF FAMILYPROTEIN (Vibrioparahaemolyticus) |
PF02743(dCache_1) | 5 | VAL A 193GLY A 210ILE A 213ALA A 201ILE A 200 | None | 1.04A | 3el0B-2p7jA:undetectable | 3el0B-2p7jA:15.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q2h | SECRETION CHAPERONE,PHAGE-DISPLAYDERIVED PEPTIDE (Agrobacteriumfabrum) |
PF01588(tRNA_bind) | 5 | LEU A 62VAL A 21ILE A 46ALA A 23ILE A 20 | None | 1.01A | 3el0B-2q2hA:undetectable | 3el0B-2q2hA:25.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q2i | SECRETION CHAPERONE (Agrobacteriumfabrum) |
PF01588(tRNA_bind) | 5 | LEU A 62VAL A 21ILE A 46ALA A 23ILE A 20 | None | 0.98A | 3el0B-2q2iA:undetectable | 3el0B-2q2iA:24.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qps | ALPHA-AMYLASE TYPE AISOZYME (Hordeum vulgare) |
PF00128(Alpha-amylase)PF07821(Alpha-amyl_C2) | 5 | LEU A 354VAL A 372ILE A 342ALA A 366ILE A 368 | None | 0.78A | 3el0B-2qpsA:undetectable | 3el0B-2qpsA:13.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qps | ALPHA-AMYLASE TYPE AISOZYME (Hordeum vulgare) |
PF00128(Alpha-amylase)PF07821(Alpha-amyl_C2) | 5 | VAL A 372ILE A 342ILE A 313ALA A 366ILE A 368 | None | 0.96A | 3el0B-2qpsA:undetectable | 3el0B-2qpsA:13.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2quq | CENTROMEREDNA-BINDING PROTEINCOMPLEX CBF3 SUBUNITB (Saccharomycescerevisiae) |
PF16846(Cep3) | 5 | VAL A 166ILE A 133GLY A 131ALA A 236ILE A 239 | None | 1.02A | 3el0B-2quqA:undetectable | 3el0B-2quqA:10.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ASP A 25GLY A 49ILE A 50PRO A 81ALA A 82ILE A 84 | NoneAB1 A 501 (-2.4A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 (-3.6A)AB1 A 501 ( 4.2A) | 0.52A | 3el0B-2rkfA:20.2 | 3el0B-2rkfA:82.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xa7 | ADAPTOR-RELATEDPROTEIN COMPLEX 2,ALPHA 2 SUBUNIT (Rattusnorvegicus) |
PF01602(Adaptin_N) | 5 | LEU A 257VAL A 309ILE A 287PRO A 253ALA A 254 | None | 1.05A | 3el0B-2xa7A:undetectable | 3el0B-2xa7A:9.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eb2 | PUTATIVEDIHYDRODIPICOLINATESYNTHETASE (Rhodopseudomonaspalustris) |
PF00701(DHDPS) | 6 | LEU A 184VAL A 150ILE A 118ILE A 125ALA A 155ILE A 151 | None | 1.43A | 3el0B-3eb2A:undetectable | 3el0B-3eb2A:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ekm | DIAMINOPIMELATEEPIMERASE,CHLOROPLASTIC (Arabidopsisthaliana) |
PF01678(DAP_epimerase) | 5 | LEU A 284GLY A 146ILE A 131ALA A 258ILE A 286 | None | 1.05A | 3el0B-3ekmA:undetectable | 3el0B-3ekmA:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3enk | UDP-GLUCOSE4-EPIMERASE (Burkholderiapseudomallei) |
PF16363(GDP_Man_Dehyd) | 5 | VAL A 31ILE A 33GLY A 17ILE A 16ILE A 7 | NoneNoneNoneNAD A 341 (-3.9A)None | 1.04A | 3el0B-3enkA:undetectable | 3el0B-3enkA:13.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i04 | CARBON MONOXIDEDEHYDROGENASE/ACETYL-COA SYNTHASESUBUNIT BETA (Moorellathermoacetica) |
PF03063(Prismane) | 5 | VAL A 292ILE A 328GLY A 314ILE A 315ILE A 291 | None | 0.93A | 3el0B-3i04A:undetectable | 3el0B-3i04A:10.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3irv | CYSTEINE HYDROLASE (Pseudomonassavastanoi) |
PF00857(Isochorismatase) | 5 | VAL A 171ILE A 184GLY A 187ALA A 51ILE A 53 | None | 0.81A | 3el0B-3irvA:undetectable | 3el0B-3irvA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m49 | TRANSKETOLASE (Bacillusanthracis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | LEU A 442VAL A 164GLY A 127ILE A 422ALA A 445 | None | 1.03A | 3el0B-3m49A:undetectable | 3el0B-3m49A:8.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mwe | ATP-CITRATE SYNTHASE (Homo sapiens) |
PF16114(Citrate_bind) | 5 | LEU A 217VAL A 121ILE A 185GLY A 187ILE A 202 | None | 0.90A | 3el0B-3mweA:undetectable | 3el0B-3mweA:14.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.55A | 3el0B-3mwsA:19.9 | 3el0B-3mwsA:74.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nwg | MICROCOMPARTMENTSPROTEIN (Desulfitobacteriumhafniense) |
PF00936(BMC) | 5 | LEU A 30VAL A 52ILE A 72ILE A 104ILE A 45 | None | 1.03A | 3el0B-3nwgA:undetectable | 3el0B-3nwgA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pz2 | GERANYLGERANYLTRANSFERASE TYPE-2SUBUNIT BETA (Rattusnorvegicus) |
PF00432(Prenyltrans) | 5 | LEU B 298VAL B 56ILE B 27GLY B 276ILE B 295 | None | 1.00A | 3el0B-3pz2B:undetectable | 3el0B-3pz2B:14.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qan | 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE1 (Bacillushalodurans) |
PF00171(Aldedh) | 5 | LEU A 204ILE A 100ILE A 108ALA A 192ILE A 231 | None | 0.98A | 3el0B-3qanA:undetectable | 3el0B-3qanA:11.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sb4 | HYPOTHETICAL LEUCINERICH REPEAT PROTEIN (Bacteroidesthetaiotaomicron) |
PF13306(LRR_5) | 5 | LEU A 159VAL A 104ILE A 76ILE A 148ILE A 135 | None | 0.95A | 3el0B-3sb4A:undetectable | 3el0B-3sb4A:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t1b | TRANSCRIPTIONALREGULATOR, LYSRFAMILY (Vibrio cholerae) |
PF00126(HTH_1)PF03466(LysR_substrate) | 5 | LEU A 124VAL A 140ILE A 282ALA A 97ILE A 95 | None | 0.87A | 3el0B-3t1bA:undetectable | 3el0B-3t1bA:16.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ALA A 82 | SO4 A 101 (-4.2A)017 A 201 (-2.6A)NoneNone017 A 201 (-4.0A)017 A 201 (-3.3A)NoneSO4 A 101 (-3.5A) | 0.84A | 3el0B-3t3cA:18.4 | 3el0B-3t3cA:79.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6p | BACULOVIRAL IAPREPEAT-CONTAININGPROTEIN 2 (Homo sapiens) |
PF00619(CARD)PF00653(BIR)PF13920(zf-C3HC4_3) | 5 | VAL A 590ILE A 604GLY A 607ILE A 608ALA A 596 | None | 0.89A | 3el0B-3t6pA:undetectable | 3el0B-3t6pA:12.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | LEU A 23ASP A 25GLY A 49ILE A 50PRO A 81ILE A 84 | None017 A 201 (-2.6A)017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.67A | 3el0B-3ttpA:19.3 | 3el0B-3ttpA:77.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | LEU A 23ASP A 25ILE A 47GLY A 49ILE A 50PRO A 81 | None017 A 202 ( 2.5A)017 A 202 (-3.6A)017 A 202 (-2.9A)017 A 201 ( 3.5A)017 A 202 (-4.0A) | 0.72A | 3el0B-3u7sA:19.4 | 3el0B-3u7sA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vps | NAD-DEPENDENTEPIMERASE/DEHYDRATASE (Streptomyceschartreusis) |
PF01370(Epimerase) | 5 | LEU A 72VAL A 34GLY A 20ILE A 19ILE A 10 | NoneNoneNoneNAD A 401 (-4.1A)None | 1.05A | 3el0B-3vpsA:undetectable | 3el0B-3vpsA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wkv | ION CHANNEL (Mus musculus) |
PF00520(Ion_trans) | 5 | VAL A 174GLY A 211ILE A 214ALA A 169ILE A 173 | None | 1.02A | 3el0B-3wkvA:undetectable | 3el0B-3wkvA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wn6 | ALPHA-AMYLASE (Oryza sativa) |
PF00128(Alpha-amylase)PF07821(Alpha-amyl_C2) | 5 | LEU A 377VAL A 395ILE A 365ALA A 389ILE A 391 | None | 0.72A | 3el0B-3wn6A:undetectable | 3el0B-3wn6A:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wn6 | ALPHA-AMYLASE (Oryza sativa) |
PF00128(Alpha-amylase)PF07821(Alpha-amyl_C2) | 5 | VAL A 395ILE A 365ILE A 336ALA A 389ILE A 391 | None | 0.89A | 3el0B-3wn6A:undetectable | 3el0B-3wn6A:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zdj | ENCA BETA-LACTAMASE (syntheticconstruct) |
PF13354(Beta-lactamase2) | 6 | LEU A 49VAL A 249ILE A 208ILE A 198ALA A 187ILE A 260 | None | 1.46A | 3el0B-3zdjA:undetectable | 3el0B-3zdjA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bma | UDP-N-ACETYLGLUCOSAMINEPYROPHOSPHORYLASE (Aspergillusfumigatus) |
PF01704(UDPGP) | 5 | VAL A 480GLY A 467ILE A 468ALA A 503ILE A 505 | None | 0.99A | 3el0B-4bmaA:undetectable | 3el0B-4bmaA:12.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bof | ARGININE DEIMINASE (Streptococcuspyogenes) |
PF02274(Amidinotransf) | 5 | LEU A 61GLY A 14ILE A 13PRO A 405ILE A 66 | None | 0.97A | 3el0B-4bofA:undetectable | 3el0B-4bofA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c7v | TRANSKETOLASE (Lactobacillussalivarius) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | LEU A 441VAL A 165GLY A 128ILE A 421ALA A 444 | None | 1.01A | 3el0B-4c7vA:undetectable | 3el0B-4c7vA:9.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4crm | TRANSLATIONINITIATION FACTORRLI1 (Saccharomycescerevisiae) |
PF00005(ABC_tran)PF00037(Fer4)PF04068(RLI) | 5 | VAL P 382GLY P 607ILE P 608ALA P 521ILE P 523 | None | 1.04A | 3el0B-4crmP:undetectable | 3el0B-4crmP:11.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4drf | METHYLTRANSFERASETYPE 12 (Ruminiclostridiumthermocellum) |
PF12623(Hen1_L) | 5 | LEU B 3VAL B 167ILE B 134ALA B 120ILE B 122 | None | 0.92A | 3el0B-4drfB:undetectable | 3el0B-4drfB:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e08 | DJ-1 BETA (Drosophilamelanogaster) |
PF01965(DJ-1_PfpI) | 5 | LEU A 149VAL A 68GLY A 87ALA A 102ILE A 100 | None | 0.91A | 3el0B-4e08A:undetectable | 3el0B-4e08A:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e4j | ARGININE DEIMINASE (Mycoplasmapenetrans) |
PF02274(Amidinotransf) | 5 | LEU A 109GLY A 62ILE A 61PRO A 444ILE A 114 | None | 0.97A | 3el0B-4e4jA:undetectable | 3el0B-4e4jA:11.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4o | HAPTOGLOBIN (Sus scrofa) |
PF00089(Trypsin) | 5 | LEU C 138VAL C 177ILE C 158ILE C 121ILE C 191 | None | 1.03A | 3el0B-4f4oC:undetectable | 3el0B-4f4oC:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ix8 | TYROSINEAMINOTRANSFERASE (Leishmaniainfantum) |
PF00155(Aminotran_1_2) | 5 | VAL A 150ILE A 255ILE A 220ALA A 157ILE A 154 | LLP A 286 ( 3.3A)LLP A 286 ( 3.8A)NoneNoneNone | 1.03A | 3el0B-4ix8A:undetectable | 3el0B-4ix8A:13.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lhu | 9C2 TCR DELTA CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 6 | LEU D 84ASP D 88ILE D 52GLY D 64ALA D 21ILE D 81 | None | 1.41A | 3el0B-4lhuD:undetectable | 3el0B-4lhuD:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nee | AP-2 COMPLEX SUBUNITALPHA-2 (Rattusnorvegicus) |
no annotation | 5 | LEU G 257VAL G 309ILE G 287PRO G 253ALA G 254 | None | 1.01A | 3el0B-4neeG:undetectable | 3el0B-4neeG:13.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | NoneRIT A 500 (-2.4A)NoneRIT A 500 ( 4.5A)RIT A 500 (-3.4A)RIT A 500 (-4.3A)RIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.62A | 3el0B-4njvA:20.0 | 3el0B-4njvA:86.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o5m | ISOVALERYL-COADEHYDROGENASE (Brucella suis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | LEU A 352GLY A 84ILE A 83ALA A 256ILE A 253 | None | 0.97A | 3el0B-4o5mA:undetectable | 3el0B-4o5mA:12.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4osp | OXYGENASE-REDUCTASE (Streptomycesfradiae) |
PF13561(adh_short_C2) | 5 | VAL A 129ILE A 142ILE A 145ALA A 124ILE A 128 | NoneNoneNAP A 301 (-4.5A)NoneNone | 1.02A | 3el0B-4ospA:undetectable | 3el0B-4ospA:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rv7 | DIADENYLATE CYCLASE (Listeriamonocytogenes) |
PF02457(DisA_N) | 5 | LEU A 50ILE A 16ILE A 60ALA A 84ILE A 81 | None | 1.02A | 3el0B-4rv7A:undetectable | 3el0B-4rv7A:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rv7 | DIADENYLATE CYCLASE (Listeriamonocytogenes) |
PF02457(DisA_N) | 5 | LEU A 58ILE A 44GLY A 47ALA A 52ILE A 81 | None | 1.04A | 3el0B-4rv7A:undetectable | 3el0B-4rv7A:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wnq | TCR VARIABLE DELTA 1CHAIN AND TCRCONSTANT ALPHA CHAIN (Homo sapiens) |
PF07686(V-set)PF09291(DUF1968) | 6 | LEU A 94ASP A 98ILE A 54GLY A 74ALA A 18ILE A 91 | None | 1.38A | 3el0B-4wnqA:undetectable | 3el0B-4wnqA:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y9v | PARTICLE-ASSOCIATEDLYASE (Acinetobactervirus AP22) |
no annotation | 5 | LEU A 354VAL A 404GLY A 394ALA A 369ILE A 382 | None | 1.02A | 3el0B-4y9vA:undetectable | 3el0B-4y9vA:8.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 5 | LEU A 30ASP A 32VAL A 39GLY A 58ILE A 100 | None4B1 A 201 (-2.9A)None4B1 A 201 (-3.4A)4B1 A 201 (-4.8A) | 0.71A | 3el0B-4ydfA:13.0 | 3el0B-4ydfA:32.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yji | ARYL ACYLAMIDASE (bacteriumCSBL00001) |
PF01425(Amidase) | 5 | LEU A 262VAL A 470GLY A 199ALA A 475ILE A 471 | None | 0.96A | 3el0B-4yjiA:undetectable | 3el0B-4yjiA:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4za2 | 2-DEOXY-D-GLUCONATE3-DEHYDROGENASE (Pectobacteriumcarotovorum) |
PF13561(adh_short_C2) | 5 | VAL A 165GLY A 94ILE A 95ALA A 160ILE A 117 | None | 0.90A | 3el0B-4za2A:undetectable | 3el0B-4za2A:16.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bq2 | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00275(EPSP_synthase) | 5 | VAL A 380ILE A 398ILE A 236ALA A 244ILE A 381 | None | 1.05A | 3el0B-5bq2A:undetectable | 3el0B-5bq2A:13.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ctm | BETA-LACTAMASE (Bacilluspumilus) |
PF00905(Transpeptidase) | 5 | LEU A 262VAL A 87GLY A 73ILE A 266PRO A 197 | None | 1.00A | 3el0B-5ctmA:undetectable | 3el0B-5ctmA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dmh | UNCHARACTERIZEDPROTEIN CONSERVED INBACTERIA (Cupriavidusnecator) |
PF07005(DUF1537)PF17042(DUF1357_C) | 6 | LEU A 179ILE A 106GLY A 232ILE A 236ALA A 207ILE A 208 | None | 1.35A | 3el0B-5dmhA:undetectable | 3el0B-5dmhA:13.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eg6 | RECOMBINING BINDINGPROTEIN SUPPRESSOROF HAIRLESS (Mus musculus) |
PF09270(BTD)PF09271(LAG1-DNAbind) | 5 | VAL C 99GLY C 130ILE C 131PRO C 97ILE C 76 | NoneNoneBU1 C 521 (-4.7A)NoneNone | 1.05A | 3el0B-5eg6C:undetectable | 3el0B-5eg6C:12.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5emi | CELL WALLHYDROLASE/AUTOLYSIN (Nostocpunctiforme) |
PF01520(Amidase_3) | 5 | VAL A 543ILE A 575ILE A 466ALA A 603ILE A 547 | None | 0.99A | 3el0B-5emiA:undetectable | 3el0B-5emiA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hrm | HALOALKYLPHOSPHORUSHYDROLASE (Sphingobium sp.TCM1) |
no annotation | 5 | LEU A 502VAL A 399ILE A 429ALA A 394ILE A 396 | None | 1.03A | 3el0B-5hrmA:undetectable | 3el0B-5hrmA:12.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5irr | SEPTIN-LIKE PROTEIN (Chlamydomonasreinhardtii) |
PF00735(Septin) | 5 | ASP A 265VAL A 322GLY A 122ALA A 353ILE A 323 | GSP A 402 (-2.8A)NoneGSP A 402 (-3.1A)NoneGSP A 402 (-4.4A) | 1.01A | 3el0B-5irrA:undetectable | 3el0B-5irrA:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jg7 | FUR REGULATEDSALMONELLA IRONTRANSPORTER (Salmonellaenterica) |
PF01297(ZnuA) | 5 | LEU A 83VAL A 38ILE A 139ALA A 43ILE A 39 | None | 1.05A | 3el0B-5jg7A:undetectable | 3el0B-5jg7A:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jvk | UNCHARACTERIZEDPROTEIN (Bacteroidescellulosilyticus) |
no annotation | 5 | VAL A 341ILE A 313GLY A 288ALA A 335ILE A 333 | NoneNoneSO4 A 651 ( 4.3A)NoneNone | 1.02A | 3el0B-5jvkA:undetectable | 3el0B-5jvkA:12.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k6o | B-GLUCOSIDASE (metagenome) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | LEU A 554ILE A 663GLY A 668PRO A 585ILE A 612 | None | 1.00A | 3el0B-5k6oA:undetectable | 3el0B-5k6oA:7.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kf7 | BIFUNCTIONAL PROTEINPUTA (Sinorhizobiummeliloti) |
PF00171(Aldedh)PF01619(Pro_dh)PF14850(Pro_dh-DNA_bdg) | 6 | LEU A 756ILE A 712ILE A 738PRO A 731ALA A 729ILE A 717 | None | 1.18A | 3el0B-5kf7A:undetectable | 3el0B-5kf7A:5.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kzh | BETA-LACTAMASE (Acinetobacterbaumannii) |
PF00905(Transpeptidase) | 5 | VAL A 235ILE A 273ILE A 263ALA A 216ILE A 214 | None | 1.01A | 3el0B-5kzhA:undetectable | 3el0B-5kzhA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l6s | GLUCOSE-1-PHOSPHATEADENYLYLTRANSFERASE (Escherichiacoli) |
PF00483(NTP_transferase) | 5 | LEU A 139VAL A 71ILE A 84ALA A 22ILE A 24 | None | 0.86A | 3el0B-5l6sA:undetectable | 3el0B-5l6sA:11.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lcn | UNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF12146(Hydrolase_4) | 5 | LEU A 159VAL A 214ILE A 175ILE A 228ALA A 155 | None | 1.00A | 3el0B-5lcnA:undetectable | 3el0B-5lcnA:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m5p | PRE-MRNA-SPLICINGHELICASE BRR2 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 5 | LEU A 796VAL A 827ILE A 734ALA A 754ILE A 801 | None | 1.01A | 3el0B-5m5pA:undetectable | 3el0B-5m5pA:4.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.57A | 3el0B-5t2zA:19.7 | 3el0B-5t2zA:81.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5te1 | ATP-CITRATE SYNTHASE (Homo sapiens) |
PF00549(Ligase_CoA)PF02629(CoA_binding)PF16114(Citrate_bind) | 5 | LEU A 217VAL A 121ILE A 185GLY A 187ILE A 202 | None | 0.93A | 3el0B-5te1A:undetectable | 3el0B-5te1A:8.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uxg | ALDEHYDEDEFORMYLATINGOXYGENASE (Sulfurisphaeratokodaii) |
no annotation | 5 | LEU A 85ILE A 184GLY A 118ALA A 173ILE A 176 | None | 1.01A | 3el0B-5uxgA:undetectable | 3el0B-5uxgA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5weo | GLUTAMATE RECEPTOR2,VOLTAGE-DEPENDENTCALCIUM CHANNELGAMMA-2 SUBUNITCHIMERA (Mus musculus;Rattusnorvegicus) |
PF00060(Lig_chan)PF00822(PMP22_Claudin)PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 5 | LEU A1114ILE A1105GLY A1151ILE A1152ALA A1144 | None | 0.99A | 3el0B-5weoA:undetectable | 3el0B-5weoA:7.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f72 | MTVAO615 (Thermothelomycesthermophila) |
no annotation | 5 | LEU A 169VAL A 551GLY A 261ALA A 143ILE A 150 | None | 0.96A | 3el0B-6f72A:undetectable | 3el0B-6f72A:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fbt | LYTIC MUREINTRANSGLYCOSYLASE (Pseudomonasaeruginosa) |
no annotation | 5 | LEU A 470VAL A 619ILE A 631GLY A 376ILE A 620 | None | 0.98A | 3el0B-6fbtA:undetectable | 3el0B-6fbtA:22.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 5 | LEU A 23ASP A 25GLY A 49PRO A 81ILE A 84 | NoneNIU A 100 (-2.8A)NIU A 100 ( 3.8A)NoneNone | 0.70A | 3el0B-6upjA:17.7 | 3el0B-6upjA:47.47 |