SIMILAR PATTERNS OF AMINO ACIDS FOR 3EL0_A_1UNA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azz COLLAGENASE

(Leptuca
pugilator) 		PF00089
(Trypsin) 		4 GLY A  61
ALA A  61
ASP A  60
THR A  54
 None
 0.66A 3el0A-1azzA:
undetectable		 3el0A-1azzA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)

(Escherichia
coli) 		PF00490
(ALAD) 		4 GLY A 305
ALA A 306
ASP A 307
ILE A 301
 None
 0.64A 3el0A-1b4eA:
undetectable		 3el0A-1b4eA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsg BETA LACTAMASE

(Streptomyces
albus) 		PF13354
(Beta-lactamase2) 		4 GLY A 248
ALA A 247
ASP A 246
ILE A 186
 None
 0.37A 3el0A-1bsgA:
undetectable		 3el0A-1bsgA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		4 GLY A 216
ALA A 217
ASP A 218
THR A 225
 None
 0.64A 3el0A-1c3xA:
undetectable		 3el0A-1c3xA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		4 ALA A  54
ASP A  53
THR A   8
ILE A  27
 None
 0.66A 3el0A-1c7jA:
undetectable		 3el0A-1c7jA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		4 ASP E  32
GLY E  34
ASP E  37
ILE E 120
 None
 0.63A 3el0A-1cziE:
6.1		 3el0A-1cziE:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLY A 106
ALA A 107
ASP A 108
ASP A 138
 None
 0.50A 3el0A-1e43A:
undetectable		 3el0A-1e43A:
11.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		8 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
THR A  80
PRO A  81
ILE A  84
 A79  A 800 (-2.7A)
A79  A 800 (-3.0A)
A79  A 800 (-3.1A)
A79  A 800 (-2.8A)
A79  A 800 ( 4.9A)
None
A79  A 800 ( 3.9A)
A79  A 800 (-3.6A)
 0.57A 3el0A-1hvcA:
13.7		 3el0A-1hvcA:
46.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		8 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
THR A  80
PRO A  81
ILE A  84
 A79  A 800 (-2.8A)
A79  A 800 (-3.0A)
A79  A 800 (-3.2A)
A79  A 800 (-2.7A)
A79  A 800 ( 4.7A)
None
A79  A 800 ( 3.4A)
A79  A 800 (-3.8A)
 0.36A 3el0A-1hvcA:
13.7		 3el0A-1hvcA:
46.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js1 TRANSCARBAMYLASE

(Bacteroides
fragilis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 GLY X 229
ALA X 230
ASP X 231
THR X 172
 None
 0.68A 3el0A-1js1X:
undetectable		 3el0A-1js1X:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2f RESPONSE REGULATOR

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 GLY A  93
ALA A  94
ASP A  95
THR A  78
 None
 0.65A 3el0A-1p2fA:
undetectable		 3el0A-1p2fA:
16.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q9p HIV-1 PROTEASE

(Homo sapiens) 		PF00077
(RVP) 		6 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
ILE A  84
 None
 0.57A 3el0A-1q9pA:
10.7		 3el0A-1q9pA:
88.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q9p HIV-1 PROTEASE

(Homo sapiens) 		PF00077
(RVP) 		6 GLY A  27
ALA A  28
ASP A  29
ASP A  30
THR A  80
ILE A  84
 None
 0.58A 3el0A-1q9pA:
10.7		 3el0A-1q9pA:
88.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q9p HIV-1 PROTEASE

(Homo sapiens) 		PF00077
(RVP) 		5 GLY A  27
ALA A  28
THR A  80
PRO A  81
ILE A  84
 None
 0.76A 3el0A-1q9pA:
10.7		 3el0A-1q9pA:
88.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		8 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
THR A  80
PRO A  81
ILE A  84
 None
 0.38A 3el0A-1sivA:
17.8		 3el0A-1sivA:
48.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		4 GLY A 307
ALA A 308
ASP A 309
ILE A 303
 None
 0.53A 3el0A-1tjrA:
undetectable		 3el0A-1tjrA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		5 GLY A 327
ASP A 287
ASP A 286
THR A 312
ILE A 329
 None
 1.24A 3el0A-1vl4A:
undetectable		 3el0A-1vl4A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7o ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Streptococcus
pneumoniae) 		PF00574
(CLP_protease) 		4 ASP A  50
ALA A  84
ASP A  85
ASP A  57
 None
 0.57A 3el0A-1y7oA:
undetectable		 3el0A-1y7oA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		4 ASP A  32
GLY A  34
ASP A  37
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
A70  A 500 (-4.8A)
 0.52A 3el0A-1zapA:
6.4		 3el0A-1zapA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zes PHOSPHATE REGULON
TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOB

(Escherichia
coli) 		PF00072
(Response_reg) 		4 GLY A  98
ALA A  99
ASP A 100
THR A  83
 None
None
None
BEF  A 201 (-3.5A)
 0.60A 3el0A-1zesA:
undetectable		 3el0A-1zesA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE

(Pseudomonas
putida;
Spinacia
oleracea) 		PF01070
(FMN_dh) 		4 GLY A 246
ALA A 247
ASP A 248
THR A 157
 None
 0.55A 3el0A-2a7nA:
undetectable		 3el0A-2a7nA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au1 IGG-DEGRADING
PROTEASE

(Streptococcus
pyogenes) 		PF09028
(Mac-1) 		4 GLY A 268
ALA A 269
ASP A 270
ILE A 239
 None
 0.53A 3el0A-2au1A:
undetectable		 3el0A-2au1A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bc0 NADH OXIDASE

(Streptococcus
pyogenes) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 453
ALA A 454
ASP A 456
ILE A 426
 None
 0.60A 3el0A-2bc0A:
undetectable		 3el0A-2bc0A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bws XAA-PRO
AMINOPEPTIDASE P

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 GLY A 262
ALA A 261
ASP A 260
ILE A 215
 None
None
MN  A1442 (-2.0A)
None
 0.63A 3el0A-2bwsA:
undetectable		 3el0A-2bwsA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4n PROTEIN NAGD

(Escherichia
coli) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ALA A  87
ASP A 112
THR A  75
ILE A 115
 None
 0.66A 3el0A-2c4nA:
undetectable		 3el0A-2c4nA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e11 HYDROLASE

(Xanthomonas
campestris) 		PF00795
(CN_hydrolase) 		4 GLY A  76
ALA A  77
ASP A  37
ILE A  79
 None
 0.66A 3el0A-2e11A:
undetectable		 3el0A-2e11A:
15.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		6 ASP A  25
GLY A  27
ALA A  28
ASP A  29
PRO A  86
ILE A  89
 LP1  A 201 (-2.3A)
LP1  A 201 (-3.8A)
LP1  A 201 (-3.5A)
LP1  A 201 (-3.6A)
LP1  A 201 (-3.9A)
LP1  A 201 (-4.2A)
 0.40A 3el0A-2fmbA:
14.5		 3el0A-2fmbA:
31.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq0 ACYL CARRIER PROTEIN

(Plasmodium
falciparum) 		PF00550
(PP-binding) 		4 GLY A  34
ALA A  35
ASP A  36
ASP A  39
 PNS  A 137 ( 3.2A)
None
PNS  A 137 (-2.3A)
None
 0.66A 3el0A-2fq0A:
undetectable		 3el0A-2fq0A:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6t CANDIDAPEPSIN-3

(Candida
albicans) 		PF00026
(Asp) 		4 ASP A  32
GLY A  34
ASP A  37
ILE A 123
 None
 0.65A 3el0A-2h6tA:
4.6		 3el0A-2h6tA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 GLY A  67
ALA A  68
ASP A  69
ILE A 101
 None
 0.64A 3el0A-2hnhA:
undetectable		 3el0A-2hnhA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ksk SUGARCANE DEFENSIN 5

(Saccharum
officinarum) 		PF00304
(Gamma-thionin) 		4 GLY A  39
THR A   4
PRO A   5
ILE A   8
 None
 0.60A 3el0A-2kskA:
undetectable		 3el0A-2kskA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nty RAC-LIKE GTP-BINDING
PROTEIN ARAC5

(Arabidopsis
thaliana) 		PF00071
(Ras) 		4 GLY C  77
ALA C  78
ASP C  79
THR C  61
 None
 0.58A 3el0A-2ntyC:
undetectable		 3el0A-2ntyC:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 GLY A 236
ALA A 237
ASP A 238
ILE A 232
 None
 0.56A 3el0A-2o7qA:
undetectable		 3el0A-2o7qA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP

(Escherichia
coli) 		PF00072
(Response_reg) 		4 GLY A  94
ALA A  95
ASP A  96
THR A  79
 None
None
None
BEF  A 205 (-3.5A)
 0.64A 3el0A-2pl1A:
undetectable		 3el0A-2pl1A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		4 ASP A  32
GLY A  34
ASP A  37
ILE A 123
 None
 0.59A 3el0A-2qzwA:
6.7		 3el0A-2qzwA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		4 ASP A  32
GLY A  34
ASP A  37
ILE A 123
 None
 0.54A 3el0A-2qzxA:
6.7		 3el0A-2qzxA:
15.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		8 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
THR A  80
PRO A  81
ILE A  84
 AB1  A 501 (-2.4A)
AB1  A 501 (-3.9A)
AB1  A 501 (-3.5A)
AB1  A 501 ( 3.3A)
AB1  A 501 (-3.8A)
None
AB1  A 501 (-4.2A)
AB1  A 501 ( 4.2A)
 0.35A 3el0A-2rkfA:
20.1		 3el0A-2rkfA:
82.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rsp RSV PROTEASE

(Rous sarcoma
virus) 		PF00077
(RVP) 		5 ASP A  37
GLY A  39
ALA A  40
ASP A  41
ILE A 108
 None
 0.44A 3el0A-2rspA:
12.8		 3el0A-2rspA:
31.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 GLY G 531
ALA G 530
ASP G 503
ILE G 547
 None
 0.67A 3el0A-2uv8G:
undetectable		 3el0A-2uv8G:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5p CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo sapiens) 		PF00040
(fn2)
PF00878
(CIMR) 		4 GLY A1719
THR A1748
PRO A1749
ILE A1722
 None
None
NAG  A2992 (-3.7A)
None
 0.68A 3el0A-2v5pA:
undetectable		 3el0A-2v5pA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn8 RETICULON-4-INTERACT
ING PROTEIN 1

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.60A 3el0A-2vn8A:
undetectable		 3el0A-2vn8A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri) 		PF01979
(Amidohydro_1) 		5 GLY A  47
ALA A  46
ASP A  45
THR A  26
ILE A   5
 None
 1.40A 3el0A-2vunA:
undetectable		 3el0A-2vunA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE

(Homo sapiens) 		PF00004
(AAA) 		4 GLY A 584
ALA A 585
ASP A 588
PRO A 623
 None
 0.65A 3el0A-2x8aA:
undetectable		 3el0A-2x8aA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbg PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 GLY A 359
ALA A 360
ASP A 361
PRO A  24
ILE A 356
 None
 0.78A 3el0A-3dbgA:
undetectable		 3el0A-3dbgA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezy DEHYDROGENASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLY A 206
ALA A 205
PRO A 155
ILE A 161
 None
 0.57A 3el0A-3ezyA:
undetectable		 3el0A-3ezyA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		4 ASP A  32
GLY A  34
ASP A  37
ILE A 117
 None
 0.54A 3el0A-3fv3A:
6.7		 3el0A-3fv3A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis) 		PF00149
(Metallophos) 		4 GLY A 121
ALA A 122
ASP A 123
ILE A 126
 None
 0.37A 3el0A-3gveA:
undetectable		 3el0A-3gveA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf3 INVERTASE

(Schwanniomyces
occidentalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 ASP A 287
GLY A 289
ASP A 291
PRO A 355
 None
None
None
NAG  A5001 ( 4.9A)
 0.61A 3el0A-3kf3A:
undetectable		 3el0A-3kf3A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l06 N-ACETYLORNITHINE
CARBAMOYLTRANSFERASE

(Xanthomonas
campestris) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 GLY A 245
ALA A 246
ASP A 247
THR A 176
 None
 0.66A 3el0A-3l06A:
undetectable		 3el0A-3l06A:
15.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		8 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
THR A  80
PRO A  81
ILE A  84
 None
 0.50A 3el0A-3mwsA:
19.0		 3el0A-3mwsA:
74.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nns DNA BINDING RESPONSE
REGULATOR B

(Thermotoga
maritima) 		PF00072
(Response_reg) 		4 GLY A  93
ALA A  94
ASP A  95
THR A  78
 None
None
None
BEF  A 402 (-3.6A)
 0.62A 3el0A-3nnsA:
undetectable		 3el0A-3nnsA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pet PUTATIVE ADHESIN

(Bacteroides
fragilis) 		PF10988
(DUF2807) 		4 GLY A  50
ALA A  49
ASP A  48
ILE A  55
 PG4  A 251 ( 4.2A)
None
None
None
 0.64A 3el0A-3petA:
undetectable		 3el0A-3petA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bacillus
halodurans) 		PF00171
(Aldedh) 		5 GLY A 354
ALA A 355
ASP A 375
ASP A 374
THR A 371
 None
 1.47A 3el0A-3prlA:
undetectable		 3el0A-3prlA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q10 PANTOATE--BETA-ALANI
NE LIGASE

(Yersinia pestis) 		PF02569
(Pantoate_ligase) 		4 GLY A  86
ALA A  87
ASP A  88
THR A  29
 None
None
None
AMP  A 501 ( 4.7A)
 0.61A 3el0A-3q10A:
undetectable		 3el0A-3q10A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE

(Francisella
tularensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 GLY A 270
ALA A 271
THR A 309
ILE A 261
 None
 0.67A 3el0A-3qtyA:
undetectable		 3el0A-3qtyA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slz GAG-PRO-POL
POLYPROTEIN

(Murine leukemia
virus) 		PF00077
(RVP) 		4 ASP A  32
GLY A  34
ALA A  35
PRO A  89
 3TL  A 126 (-2.4A)
3TL  A 126 (-3.1A)
3TL  A 126 ( 4.0A)
3TL  A 126 (-4.0A)
 0.61A 3el0A-3slzA:
11.0		 3el0A-3slzA:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ALA A  28
ASP A  29
ASP A  30
THR A  80
PRO A  81
 017  A 201 (-3.5A)
017  A 201 (-3.5A)
017  A 201 (-4.2A)
None
None
 0.37A 3el0A-3t3cA:
18.1		 3el0A-3t3cA:
79.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
THR A  80
 017  A 201 (-2.6A)
017  A 201 (-3.4A)
017  A 201 (-3.5A)
017  A 201 (-3.5A)
017  A 201 (-4.2A)
None
 0.28A 3el0A-3t3cA:
18.1		 3el0A-3t3cA:
79.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		8 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
THR A  80
PRO A  81
ILE A  84
 017  A 201 (-2.6A)
017  A 201 (-3.6A)
017  A 201 (-3.4A)
017  A 201 (-3.3A)
017  A 201 (-4.6A)
None
017  A 201 (-4.1A)
017  A 201 (-4.7A)
 0.36A 3el0A-3ttpA:
18.8		 3el0A-3ttpA:
77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u7s POL POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		7 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
THR A  80
PRO A  81
 017  A 202 ( 2.5A)
017  A 201 ( 3.5A)
017  A 201 (-3.4A)
017  A 201 (-3.2A)
017  A 201 ( 4.0A)
None
017  A 202 (-4.0A)
 0.34A 3el0A-3u7sA:
19.2		 3el0A-3u7sA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uhl PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 ASP A  25
GLY A  27
ALA A  28
ASP A  29
THR A  80
PRO A  81
 None
 0.51A 3el0A-3uhlA:
16.6		 3el0A-3uhlA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9s OMPR FAMILY RESPONSE
REGULATOR IN
TWO-COMPONENT
REGULATORY SYSTEM
WITH BASS

(Klebsiella
pneumoniae) 		PF00072
(Response_reg) 		4 GLY A  94
ALA A  95
ASP A  96
THR A  79
 None
None
None
BEF  A 201 (-3.7A)
 0.60A 3el0A-3w9sA:
undetectable		 3el0A-3w9sA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 ASP A 292
GLY A 294
ASP A 296
PRO A 363
 None
 0.57A 3el0A-4fffA:
undetectable		 3el0A-4fffA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqu PUTATIVE GLUTATHIONE
TRANSFERASE

(Sphingobium
chlorophenolicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 GLY A 101
ALA A 102
ASP A 103
PRO A 114
 None
 0.68A 3el0A-4fquA:
undetectable		 3el0A-4fquA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbo E7

(Thermobifida
fusca) 		PF03067
(LPMO_10) 		4 GLY A 145
ALA A 146
ASP A 147
THR A 202
 None
 0.66A 3el0A-4gboA:
undetectable		 3el0A-4gboA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Salipiger
bermudensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 318
ALA A 319
ASP A 292
PRO A 346
ILE A 343
 None
None
0XW  A 403 ( 4.4A)
None
None
 1.28A 3el0A-4h2hA:
undetectable		 3el0A-4h2hA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdy PERIPLASMIC BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01497
(Peripla_BP_2) 		4 GLY A 248
ALA A 249
ASP A 250
PRO A 216
 None
 0.68A 3el0A-4mdyA:
undetectable		 3el0A-4mdyA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		8 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
THR A  80
PRO A  81
ILE A  84
 RIT  A 500 (-2.4A)
RIT  A 500 (-3.9A)
RIT  A 500 (-3.6A)
RIT  A 500 (-3.2A)
RIT  A 500 (-4.8A)
None
RIT  A 500 (-3.9A)
RIT  A 500 (-4.3A)
 0.53A 3el0A-4njvA:
19.6		 3el0A-4njvA:
86.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy8 PUTATIVE SECRETED
CELLULOSE-BINDING
PROTEIN

(Streptomyces
coelicolor) 		PF03067
(LPMO_10) 		4 GLY A 151
ALA A 152
ASP A 153
THR A 208
 None
 0.62A 3el0A-4oy8A:
undetectable		 3el0A-4oy8A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph8 AGGREGATIVE
ADHERENCE FIMBRIAL
SUBUNIT AGGA

(Escherichia
coli) 		no annotation 4 ASP A  83
GLY A  85
ALA A  86
ASP A  87
 None
 0.56A 3el0A-4ph8A:
undetectable		 3el0A-4ph8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II

(Yersinia pestis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 GLY A 260
ALA A 259
ASP A 258
ILE A 213
 None
None
MG  A 501 ( 2.0A)
None
 0.64A 3el0A-4pv4A:
undetectable		 3el0A-4pv4A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgh PROTEIN DDI1 HOMOLOG
2

(Homo sapiens) 		PF09668
(Asp_protease) 		4 ASP A 220
GLY A 222
ALA A 223
PRO A 285
 None
 0.58A 3el0A-4rghA:
10.4		 3el0A-4rghA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Listeria
monocytogenes) 		PF00574
(CLP_protease) 		4 ASP H  52
ALA H  86
ASP H  87
ASP H  59
 None
 0.59A 3el0A-4ryfH:
undetectable		 3el0A-4ryfH:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr6 DNA POLYMERASE III
SUBUNIT BETA

(Bacillus
subtilis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 ALA A 122
ASP A 123
ASP A 121
THR A 106
ILE A  77
 None
 1.47A 3el0A-4tr6A:
undetectable		 3el0A-4tr6A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		4 GLY A 599
ALA A 600
ASP A 601
THR A 582
 PO4  A 804 (-3.9A)
None
None
None
 0.52A 3el0A-4u1rA:
undetectable		 3el0A-4u1rA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u5x RAC-LIKE GTP-BINDING
PROTEIN 1

(Oryza sativa) 		PF00071
(Ras) 		4 GLY A  81
ALA A  82
ASP A  83
THR A  65
 None
None
GOL  A 204 (-3.4A)
None
 0.60A 3el0A-4u5xA:
undetectable		 3el0A-4u5xA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhk TRANSCRIPTIONAL
REGULATORY PROTEIN
CPXR

(Escherichia
coli) 		PF00072
(Response_reg) 		4 GLY A  93
ALA A  94
ASP A  95
THR A  78
 None
None
None
PHD  A  51 ( 3.6A)
 0.58A 3el0A-4uhkA:
undetectable		 3el0A-4uhkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1

(Homo sapiens) 		PF00569
(ZZ)
PF06701
(MIB_HERC2) 		5 GLY A  15
ALA A  16
ASP A  72
THR A 128
ILE A  70
 None
None
None
SO4  A 403 (-3.1A)
None
 1.16A 3el0A-4xibA:
undetectable		 3el0A-4xibA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		4 ASP A  32
GLY A  34
ASP A  37
ILE A 116
 None
 0.55A 3el0A-4y9wA:
6.9		 3el0A-4y9wA:
16.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydf HTLV-1 PROTEASE

(Primate
T-lymphotropic
virus 1) 		PF00077
(RVP) 		5 ASP A  32
GLY A  34
ALA A  35
ASP A  36
ILE A 100
 4B1  A 201 (-2.9A)
4B1  A 201 ( 4.6A)
4B1  A 201 (-3.6A)
4B1  A 201 (-4.4A)
4B1  A 201 (-4.8A)
 0.40A 3el0A-4ydfA:
12.6		 3el0A-4ydfA:
32.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 GLY A 462
ALA A 463
ASP A 464
THR A 531
ILE A 513
 None
 1.42A 3el0A-5a5gA:
undetectable		 3el0A-5a5gA:
10.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b18 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ASP A  29
ASP A  30
THR A  80
PRO A  81
ILE A  84
 None
 0.59A 3el0A-5b18A:
17.9		 3el0A-5b18A:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b18 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 GLY A  27
ALA A  28
ASP A  29
ASP A  30
THR A  80
ILE A  84
 None
 0.41A 3el0A-5b18A:
17.9		 3el0A-5b18A:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9d APRICK PROTEASE

(Rickettsia
conorii) 		PF13975
(gag-asp_proteas) 		4 ASP A 140
GLY A 142
ALA A 143
ASP A 145
 None
 0.45A 3el0A-5c9dA:
8.5		 3el0A-5c9dA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cad SM80.1 VICILIN

(Solanum
melongena) 		PF00190
(Cupin_1) 		4 GLY A 338
ALA A 244
ASP A 243
ILE A  72
 None
 0.64A 3el0A-5cadA:
undetectable		 3el0A-5cadA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3j RESPONSE REGULATOR
RSTA

(Acinetobacter
baumannii) 		PF00072
(Response_reg) 		4 GLY A 100
ALA A 101
ASP A 102
THR A  85
 None
 0.67A 3el0A-5e3jA:
undetectable		 3el0A-5e3jA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 GLY C 226
ALA C 227
ASP C 251
ILE C 221
 None
None
None
KCX  C 220 ( 4.2A)
 0.64A 3el0A-5fseC:
undetectable		 3el0A-5fseC:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j60 THIOREDOXIN
REDUCTASE

(Gloeobacter
violaceus) 		PF07992
(Pyr_redox_2) 		4 GLY A 184
ALA A 186
THR A 175
PRO A 176
 None
 0.64A 3el0A-5j60A:
undetectable		 3el0A-5j60A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldd RAB SMALL MONOMERIC
GTPASE-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00071
(Ras) 		4 GLY C  80
ALA C  81
ASP C  82
THR C  64
 None
 0.59A 3el0A-5lddC:
undetectable		 3el0A-5lddC:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 4 ASP A  80
GLY A  82
ASP A  85
ILE A 169
 None
 0.61A 3el0A-5nfgA:
7.0		 3el0A-5nfgA:
14.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t2z PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		8 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
THR A  80
PRO A  81
ILE A  84
 None
 0.30A 3el0A-5t2zA:
19.5		 3el0A-5t2zA:
81.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		4 ASP A 253
ASP A 257
THR A 268
PRO A 269
 None
 0.62A 3el0A-5tj3A:
undetectable		 3el0A-5tj3A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Pseudomonas
syringae) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 GLY A 115
ALA A 116
ASP A 117
THR A  56
 None
 0.48A 3el0A-5u5gA:
undetectable		 3el0A-5u5gA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uic TWO-COMPONENT
RESPONSE REGULATOR

(Francisella
tularensis) 		PF00072
(Response_reg) 		4 GLY A  94
ALA A  95
ASP A  96
THR A  79
 None
 0.54A 3el0A-5uicA:
undetectable		 3el0A-5uicA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve3 BPPRF

(Paraburkholderia
phytofirmans) 		no annotation 4 GLY B  88
ALA B  89
ASP B  90
ILE B  80
 None
 0.68A 3el0A-5ve3B:
undetectable		 3el0A-5ve3B:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf5 SM80.1 VICILIN

(Solanum
melongena) 		no annotation 4 GLY A 343
ALA A 243
ASP A 242
ILE A  72
 None
 0.65A 3el0A-5vf5A:
undetectable		 3el0A-5vf5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY

(uncultured
archaeon
MedDCM-OCT-S05-C57) 		no annotation 5 GLY A 192
ALA A 188
ASP A 187
THR A 296
ILE A 249
 None
 0.99A 3el0A-5y1gA:
undetectable		 3el0A-5y1gA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Enterococcus
faecium) 		no annotation 4 ASP A  52
ALA A  86
ASP A  87
ASP A  59
 None
 0.56A 3el0A-6cfdA:
undetectable		 3el0A-6cfdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fiv RETROPEPSIN

(Feline
immunodeficiency
virus) 		PF00077
(RVP) 		4 ASP A  30
GLY A  32
ALA A  33
ASP A  34
 3TL  A 201 (-3.5A)
3TL  A 201 (-3.4A)
3TL  A 201 (-4.0A)
3TL  A 201 (-3.9A)
 0.28A 3el0A-6fivA:
14.8		 3el0A-6fivA:
29.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6upj HIV-2 PROTEASE

(Human
immunodeficiency
virus 2) 		PF00077
(RVP) 		8 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
THR A  80
PRO A  81
ILE A  84
 NIU  A 100 (-2.8A)
NIU  A 100 (-4.5A)
NIU  A 100 (-3.6A)
None
None
None
None
None
 0.57A 3el0A-6upjA:
17.4		 3el0A-6upjA:
47.47