SIMILAR PATTERNS OF AMINO ACIDS FOR 3EIG_A_MTXA200

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2e ELONGATION FACTOR TU
(EF-TU)

(Bos taurus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 ILE A  95
ALA A  98
GLU A 114
PRO A 143
ASN A  59
 None
 1.23A 3eigA-1d2eA:
undetectable		 3eigA-1d2eA:
19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		8 ILE A   7
ALA A   9
LEU A  22
GLU A  30
SER A  59
ASN A  64
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
NAP  A 191 ( 4.1A)
None
None
None
 0.77A 3eigA-1dr6A:
30.5		 3eigA-1dr6A:
74.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		8 ILE A   7
ALA A   9
LEU A  22
GLU A  30
SER A  59
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
NAP  A 191 ( 4.1A)
None
None
None
 0.44A 3eigA-1dr6A:
30.5		 3eigA-1dr6A:
74.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		8 ILE A   7
ALA A   9
LEU A  22
SER A  59
PRO A  61
ASN A  64
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
None
None
None
 0.77A 3eigA-1dr6A:
30.5		 3eigA-1dr6A:
74.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		8 ILE A   7
ALA A   9
LEU A  22
SER A  59
PRO A  61
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
None
None
None
 0.59A 3eigA-1dr6A:
30.5		 3eigA-1dr6A:
74.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjq BETA-1,4-GALACTANASE

(Humicola
insolens) 		PF07745
(Glyco_hydro_53) 		5 ILE A 125
ALA A  69
ASN A  58
LEU A  59
ARG A 119
 None
 1.20A 3eigA-1hjqA:
undetectable		 3eigA-1hjqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR

(Homo sapiens) 		PF00079
(Serpin) 		5 ILE A 122
ALA A  68
GLU A 125
PRO A 180
LEU A 149
 None
 1.34A 3eigA-1imvA:
undetectable		 3eigA-1imvA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi8 DNAB INTEIN

(Synechocystis
sp. PCC 6803) 		PF14890
(Intein_splicing) 		5 ILE A 151
ALA A 147
LEU A 137
GLU A  41
PRO A 140
 None
 1.17A 3eigA-1mi8A:
undetectable		 3eigA-1mi8A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ILE B 286
LEU B 246
GLU B 284
PRO B 242
ASN B 241
 None
 1.37A 3eigA-1pjmB:
undetectable		 3eigA-1pjmB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0z ACLACINOMYCIN
METHYLESTERASE

(Streptomyces
purpurascens) 		PF00561
(Abhydrolase_1) 		5 ILE A 107
ALA A  82
PRO A  74
LEU A 222
TYR A  57
 None
 1.33A 3eigA-1q0zA:
undetectable		 3eigA-1q0zA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 ILE A 304
ALA A 141
LEU A 242
ARG A 257
TYR A 234
 None
 1.45A 3eigA-1qe0A:
undetectable		 3eigA-1qe0A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 ILE A  61
ALA A  57
LEU A   3
ASN A  32
LEU A  33
 None
 1.34A 3eigA-1qgrA:
undetectable		 3eigA-1qgrA:
12.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u70 DIHYDROFOLATE
REDUCTASE

(Mus musculus) 		PF00186
(DHFR_1) 		8 ILE A   7
ALA A   9
GLU A  30
PRO A  61
ASN A  64
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 (-4.8A)
MTX  A 187 (-3.6A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.38A 3eigA-1u70A:
30.3		 3eigA-1u70A:
88.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u70 DIHYDROFOLATE
REDUCTASE

(Mus musculus) 		PF00186
(DHFR_1) 		6 ILE A   7
SER A  59
PRO A  61
ASN A  64
LEU A  67
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 ( 3.8A)
MTX  A 187 (-4.8A)
MTX  A 187 (-3.6A)
MTX  A 187 ( 4.5A)
None
 0.67A 3eigA-1u70A:
30.3		 3eigA-1u70A:
88.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u71 DIHYDROFOLATE
REDUCTASE

(Homo sapiens) 		PF00186
(DHFR_1) 		9 ILE A   7
ALA A   9
GLU A  30
SER A  59
PRO A  61
ASN A  64
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-3.8A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.5A)
None
None
None
 0.58A 3eigA-1u71A:
33.0		 3eigA-1u71A:
98.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd7 2-KETO
ACID:FERREDOXIN
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF01855
(POR_N) 		5 ILE A  15
ALA A  22
GLU A  11
PRO A 193
ASN A 192
 None
 1.35A 3eigA-1yd7A:
undetectable		 3eigA-1yd7A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1za7 COAT PROTEIN

(Cowpea
chlorotic
mottle virus) 		PF01318
(Bromo_coat) 		5 ILE A 145
ALA A 151
LEU A  74
GLU A 176
PRO A 180
 None
 1.45A 3eigA-1za7A:
undetectable		 3eigA-1za7A:
23.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		5 ILE A   5
ALA A   7
LEU A  20
LEU A  54
ARG A  57
 None
None
None
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.53A 3eigA-1zdrA:
19.7		 3eigA-1zdrA:
33.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 GLU B  45
SER B 126
ASN B  44
LEU B  43
ARG B 215
 None
 1.34A 3eigA-2bg9B:
undetectable		 3eigA-2bg9B:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2blb DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
vivax) 		PF00186
(DHFR_1) 		8 ILE A  13
ALA A  15
LEU A  45
SER A 120
PRO A 122
LEU A 128
ARG A 131
TYR A 179
 CP7  A1240 (-4.1A)
CP7  A1240 (-3.7A)
NDP  A1239 (-4.8A)
NDP  A1239 (-3.6A)
None
MES  A1241 (-4.5A)
MES  A1241 (-2.7A)
None
 0.73A 3eigA-2blbA:
21.6		 3eigA-2blbA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs9 HYPOTHETICAL PROTEIN
TT1324

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		5 LEU A 134
GLU A  26
SER A 138
PRO A 204
LEU A 182
 None
 1.19A 3eigA-2gs9A:
2.6		 3eigA-2gs9A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		6 ALA A  28
SER A  83
PRO A  85
LEU A  91
ARG A  94
TYR A 160
 NAP  A 523 (-3.7A)
NAP  A 523 ( 4.4A)
None
None
None
None
 0.59A 3eigA-2h2qA:
21.5		 3eigA-2h2qA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE

(Synechococcus
elongatus) 		PF13672
(PP2C_2) 		5 ILE A  83
LEU A 163
GLU A  43
SER A 120
ASN A 232
 None
 1.26A 3eigA-2j86A:
undetectable		 3eigA-2j86A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		6 ALA A  11
LEU A  25
SER A  61
LEU A  67
ARG A  70
TYR A 119
 MTX  A 605 ( 3.6A)
MTX  A 605 ( 4.6A)
NDP  A 606 ( 4.5A)
MTX  A 605 ( 4.4A)
MTX  A 605 ( 3.1A)
None
 0.65A 3eigA-2oipA:
22.0		 3eigA-2oipA:
17.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qk8 DIHYDROFOLATE
REDUCTASE

(Bacillus
anthracis) 		PF00186
(DHFR_1) 		6 ALA A   8
LEU A  21
GLU A  28
LEU A  55
ARG A  58
TYR A 102
 MTX  A 200 ( 3.4A)
MTX  A 200 ( 4.5A)
MTX  A 200 ( 2.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 2.8A)
None
 0.68A 3eigA-2qk8A:
21.2		 3eigA-2qk8A:
33.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkd ZINC FINGER PROTEIN
ZPR1

(Mus musculus) 		PF03367
(zf-ZPR1) 		5 ILE A 361
LEU A 325
GLU A 334
SER A 412
ASN A 406
 None
None
FMT  A 778 (-4.4A)
None
FMT  A 778 (-3.8A)
 1.43A 3eigA-2qkdA:
undetectable		 3eigA-2qkdA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		5 ILE A 207
GLU A 229
SER A 324
PRO A 193
LEU A 188
 None
 1.37A 3eigA-2tohA:
undetectable		 3eigA-2tohA:
19.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w3w DIHYDROFOLATE
REDUCTASE

(Mycobacterium
avium) 		PF00186
(DHFR_1) 		5 ALA A  11
PRO A  55
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.76A 3eigA-2w3wA:
21.2		 3eigA-2w3wA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w3w DIHYDROFOLATE
REDUCTASE

(Mycobacterium
avium) 		PF00186
(DHFR_1) 		5 ALA A  11
SER A  53
PRO A  55
LEU A  61
TYR A 108
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
None
 0.67A 3eigA-2w3wA:
21.2		 3eigA-2w3wA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9s DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		5 ALA A   7
LEU A  20
SER A  49
LEU A  54
TYR A  98
 TOP  A1160 ( 3.6A)
TOP  A1160 ( 4.2A)
TOP  A1160 (-3.5A)
None
None
 1.02A 3eigA-2w9sA:
20.1		 3eigA-2w9sA:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9s DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		6 ILE A   5
ALA A   7
LEU A  20
LEU A  54
ARG A  57
TYR A  98
 TOP  A1160 (-4.2A)
TOP  A1160 ( 3.6A)
TOP  A1160 ( 4.2A)
None
None
None
 0.61A 3eigA-2w9sA:
20.1		 3eigA-2w9sA:
32.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byw PUTATIVE
ARABINOFURANOSYLTRAN
SFERASE

(Corynebacterium
diphtheriae) 		PF04602
(Arabinose_trans) 		5 ILE A 137
ALA A 188
LEU A 186
SER A  73
LEU A 109
 None
 1.41A 3eigA-3bywA:
undetectable		 3eigA-3bywA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dfr DIHYDROFOLATE
REDUCTASE

(Lactobacillus
casei) 		PF00186
(DHFR_1) 		6 ALA A   6
LEU A  19
SER A  48
PRO A  50
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.83A 3eigA-3dfrA:
20.8		 3eigA-3dfrA:
31.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg8 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1) 		8 ILE A  14
ALA A  16
LEU A  46
SER A 111
PRO A 113
LEU A 119
ARG A 122
TYR A 170
 RJ6  A 609 (-4.5A)
RJ6  A 609 (-3.7A)
RJ6  A 609 (-3.8A)
RJ6  A 609 ( 3.8A)
None
RJ6  A 609 (-4.4A)
None
NDP  A 610 ( 4.9A)
 0.67A 3eigA-3dg8A:
21.9		 3eigA-3dg8A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Listeria
innocua) 		PF00155
(Aminotran_1_2) 		5 ILE A 158
ALA A 111
LEU A 134
PRO A 299
TYR A 118
 None
 1.24A 3eigA-3ffhA:
undetectable		 3eigA-3ffhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 ILE A 369
LEU A 402
GLU A  35
GLU A  66
SER A 358
 None
 1.20A 3eigA-3h9uA:
undetectable		 3eigA-3h9uA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Candida
albicans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ILE A 150
ALA A 103
LEU A 359
PRO A 126
ASN A 125
 None
 1.44A 3eigA-3hskA:
undetectable		 3eigA-3hskA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8a DIHYDROFOLATE
REDUCTASE

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		5 ALA X   7
LEU X  20
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
None
None
 0.79A 3eigA-3i8aX:
19.9		 3eigA-3i8aX:
29.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ia4 DIHYDROFOLATE
REDUCTASE

(Moritella
profunda) 		PF00186
(DHFR_1) 		7 ILE A   6
ALA A   8
GLU A  28
SER A  50
LEU A  55
ARG A  58
TYR A 102
 MTX  A 164 (-4.0A)
MTX  A 164 ( 3.7A)
MTX  A 164 (-2.9A)
NDP  A 163 ( 3.8A)
MTX  A 164 ( 4.4A)
MTX  A 164 (-2.9A)
None
 0.67A 3eigA-3ia4A:
20.2		 3eigA-3ia4A:
30.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ita D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 ILE A 103
GLU A 181
GLU A 174
SER A  94
LEU A  54
 None
 1.16A 3eigA-3itaA:
undetectable		 3eigA-3itaA:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ix9 DIHYDROFOLATE
REDUCTASE

(Streptococcus
pneumoniae) 		PF00186
(DHFR_1) 		6 ILE A   8
ALA A  10
LEU A  23
GLU A  30
LEU A  58
ARG A  61
 MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
NDP  A 193 ( 4.1A)
MTX  A 200 (-2.7A)
MTX  A 200 ( 4.0A)
MTX  A 200 (-2.9A)
 0.69A 3eigA-3ix9A:
20.7		 3eigA-3ix9A:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ALA A  16
SER A  72
LEU A  80
ARG A  83
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
 0.70A 3eigA-3kjrA:
22.1		 3eigA-3kjrA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ALA A  16
SER A  72
PRO A  74
LEU A  80
TYR A 129
 NAP  A 512 (-3.7A)
NAP  A 512 ( 4.2A)
None
None
None
 0.92A 3eigA-3kjrA:
22.1		 3eigA-3kjrA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2e SHIKIMATE KINASE

(Helicobacter
pylori) 		PF01202
(SKI) 		5 ILE A  76
ALA A  18
LEU A  97
GLU A  60
LEU A  88
 None
 1.25A 3eigA-3n2eA:
undetectable		 3eigA-3n2eA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pic CIP2

(Trichoderma
reesei) 		no annotation 5 ILE A 195
GLU A 260
PRO A 152
ARG A 293
TYR A 197
 None
 1.34A 3eigA-3picA:
undetectable		 3eigA-3picA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg9 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
brucei) 		PF00186
(DHFR_1) 		6 ALA A  34
SER A  89
PRO A  91
LEU A  97
ARG A 100
TYR A 166
 WRA  A 602 (-3.9A)
WRA  A 602 ( 4.2A)
WRA  A 602 (-4.3A)
None
None
None
 0.69A 3eigA-3rg9A:
21.8		 3eigA-3rg9A:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrv ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 ILE A  86
ALA A 230
LEU A 150
GLU A  91
SER A 117
 None
 1.08A 3eigA-3rrvA:
undetectable		 3eigA-3rrvA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxz POLYSACCHARIDE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		PF01522
(Polysacc_deac_1) 		5 LEU A 183
GLU A 185
GLU A 147
ASN A 149
LEU A 111
 None
 1.32A 3eigA-3rxzA:
undetectable		 3eigA-3rxzA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tq9 DIHYDROFOLATE
REDUCTASE

(Coxiella
burnetii) 		PF00186
(DHFR_1) 		6 ILE A   6
ALA A   8
LEU A  21
SER A  50
LEU A  55
ARG A  58
 MTX  A2001 (-4.0A)
MTX  A2001 ( 3.4A)
MTX  A2001 (-4.4A)
NDP  A1001 ( 3.0A)
MTX  A2001 ( 4.5A)
MTX  A2001 (-2.8A)
 0.77A 3eigA-3tq9A:
20.6		 3eigA-3tq9A:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 151
ALA A 227
PRO A 215
ASN A 216
LEU A 162
 None
 1.38A 3eigA-3tqpA:
undetectable		 3eigA-3tqpA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		7 ILE A  14
LEU A  46
SER A 111
PRO A 113
LEU A 119
ARG A 122
TYR A 170
 1CY  A 609 (-4.3A)
NDP  A 610 (-4.4A)
1CY  A 609 ( 4.4A)
None
None
None
None
 0.66A 3eigA-3um6A:
21.9		 3eigA-3um6A:
13.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vco DIHYDROFOLATE
REDUCTASE

(Schistosoma
mansoni) 		PF00186
(DHFR_1) 		6 ALA A   8
SER A  56
PRO A  58
LEU A  64
ARG A  67
TYR A 117
 None
 0.51A 3eigA-3vcoA:
24.1		 3eigA-3vcoA:
36.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vus POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF01522
(Polysacc_deac_1) 		5 ILE A 287
ALA A 281
LEU A 104
GLU A 180
PRO A 134
 None
 1.36A 3eigA-3vusA:
undetectable		 3eigA-3vusA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4

(Mus musculus) 		PF00225
(Kinesin) 		5 ALA A 331
LEU A  14
GLU A 323
PRO A 316
LEU A 321
 None
 1.37A 3eigA-3zfcA:
undetectable		 3eigA-3zfcA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boo ACETYLCHOLINE
RECEPTOR BETA
SUBUNIT

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 GLU B  45
SER B 126
ASN B  44
LEU B  43
ARG B 215
 None
 1.34A 3eigA-4booB:
undetectable		 3eigA-4booB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9d POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF01522
(Polysacc_deac_1)
PF14883
(GHL13) 		5 ILE A 287
ALA A 281
LEU A 104
GLU A 180
PRO A 134
 None
 1.38A 3eigA-4f9dA:
undetectable		 3eigA-4f9dA:
13.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g8z DIHYDROFOLATE
REDUCTASE

(Pneumocystis
jirovecii) 		PF00186
(DHFR_1) 		10 ILE X  10
ALA X  12
LEU X  25
GLU X  32
SER X  64
PRO X  66
ASN X  69
LEU X  72
ARG X  75
TYR X 129
 TOP  X 301 (-4.2A)
NDP  X 302 ( 3.8A)
TOP  X 301 ( 4.0A)
TOP  X 301 (-3.0A)
TOP  X 301 (-3.3A)
TOP  X 301 (-4.8A)
None
None
None
None
 0.87A 3eigA-4g8zX:
24.7		 3eigA-4g8zX:
37.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h96 DIHYDROFOLATE
REDUCTASE

(Candida
albicans) 		PF00186
(DHFR_1) 		6 ILE A   9
ALA A  11
GLU A  32
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
None
None
None
 0.48A 3eigA-4h96A:
20.4		 3eigA-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h96 DIHYDROFOLATE
REDUCTASE

(Candida
albicans) 		PF00186
(DHFR_1) 		6 ILE A   9
ALA A  11
PRO A  63
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
None
None
None
 0.89A 3eigA-4h96A:
20.4		 3eigA-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h96 DIHYDROFOLATE
REDUCTASE

(Candida
albicans) 		PF00186
(DHFR_1) 		6 ILE A   9
SER A  61
PRO A  63
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 (-3.9A)
None
None
None
None
 0.79A 3eigA-4h96A:
20.4		 3eigA-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h98 DIHYDROFOLATE
REDUCTASE

([Candida]
glabrata) 		PF00186
(DHFR_1) 		9 ILE A   9
ALA A  11
LEU A  25
GLU A  32
SER A  61
PRO A  63
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.4A)
None
None
None
 0.78A 3eigA-4h98A:
21.1		 3eigA-4h98A:
37.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iru LEPB

(Legionella
pneumophila) 		no annotation 5 ILE A 584
ALA A 587
GLU A 561
ASN A 563
LEU A 562
 None
None
None
GOL  A 905 ( 4.4A)
K  A 911 (-4.8A)
 1.38A 3eigA-4iruA:
undetectable		 3eigA-4iruA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 5 ILE A 584
ALA A 587
GLU A 561
ASN A 563
LEU A 562
 None
 1.39A 3eigA-4jw1A:
undetectable		 3eigA-4jw1A:
16.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m2x DIHYDROFOLATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF00186
(DHFR_1) 		7 ILE A   5
ALA A   7
SER A  49
PRO A  51
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
NDP  A 201 (-3.6A)
TMQ  A 202 (-4.2A)
None
None
None
 0.68A 3eigA-4m2xA:
20.5		 3eigA-4m2xA:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m7v DIHYDROFOLATE
REDUCTASE

(Enterococcus
faecalis) 		PF00186
(DHFR_1) 		5 ILE A   5
ALA A   7
LEU A  20
LEU A  55
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.68A 3eigA-4m7vA:
20.0		 3eigA-4m7vA:
31.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 ALA B 116
GLU A 138
SER B 145
LEU A 135
TYR A 117
 None
 1.26A 3eigA-4mrmB:
2.4		 3eigA-4mrmB:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermococcus
kodakarensis) 		PF03009
(GDPD) 		5 ILE A 130
ALA A 137
GLU A  39
ASN A  22
LEU A  40
 None
None
MG  A 401 (-2.6A)
None
None
 1.37A 3eigA-4oecA:
undetectable		 3eigA-4oecA:
23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p68 DIHYDROFOLATE
REDUCTASE

(Escherichia
coli) 		PF00186
(DHFR_1) 		5 ILE A   5
ALA A   7
SER A  49
ARG A  57
TYR A 100
 MTX  A 201 (-4.1A)
MTX  A 201 ( 4.0A)
MTX  A 201 ( 3.7A)
MTX  A 201 (-3.0A)
None
 0.66A 3eigA-4p68A:
20.0		 3eigA-4p68A:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		5 ILE A 386
LEU A 275
GLU A 389
PRO A 180
ARG A  89
 None
None
MVL  A 501 (-2.8A)
None
None
 1.27A 3eigA-4re2A:
undetectable		 3eigA-4re2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 ALA A2674
LEU A2644
GLU A2713
SER A2650
LEU A2712
 None
None
ADP  A4406 ( 4.3A)
None
None
 1.43A 3eigA-4rh7A:
undetectable		 3eigA-4rh7A:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica) 		PF13407
(Peripla_BP_4) 		5 ALA A 268
LEU A 111
PRO A  32
ASN A  33
LEU A  34
 None
 1.38A 3eigA-4rxmA:
undetectable		 3eigA-4rxmA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		5 ALA A 144
GLU A 135
SER A 128
PRO A 130
LEU A 405
 None
 1.22A 3eigA-4tpnA:
undetectable		 3eigA-4tpnA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzg SURFACE PROTEIN SPB1

(Streptococcus
agalactiae) 		no annotation 5 ALA A 318
LEU A 325
GLU A 416
ASN A 453
LEU A 441
 None
 1.34A 3eigA-4uzgA:
undetectable		 3eigA-4uzgA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v23 MATRIX PROTEIN

(Respiratory
syncytial virus) 		PF03393
(Pneumo_matrix) 		5 ILE A 204
LEU A 226
PRO A 196
ASN A   6
LEU A   8
 None
 1.39A 3eigA-4v23A:
undetectable		 3eigA-4v23A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y13 TRANSCRIPTIONAL
REGULATOR OF FTSQAZ
GENE CLUSTER

(Escherichia
coli) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		5 ALA A 110
LEU A 106
ASN A  87
LEU A  93
TYR A  63
 GOL  A 304 (-2.8A)
480  A 303 ( 4.5A)
None
None
480  A 303 (-4.3A)
 1.35A 3eigA-4y13A:
undetectable		 3eigA-4y13A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypl LON PROTEASE

(Meiothermus
taiwanensis) 		PF00004
(AAA)
PF05362
(Lon_C) 		5 ALA A 724
GLU A 745
PRO A 736
ASN A 739
LEU A 743
 None
 1.25A 3eigA-4yplA:
undetectable		 3eigA-4yplA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypl LON PROTEASE

(Meiothermus
taiwanensis) 		PF00004
(AAA)
PF05362
(Lon_C) 		5 ALA A 724
LEU A 600
GLU A 745
PRO A 736
LEU A 743
 None
 1.20A 3eigA-4yplA:
undetectable		 3eigA-4yplA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A

(Thermotoga
maritima) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 ILE B 442
GLU B 117
GLU B 196
PRO B 189
LEU B 179
 SF4  B 502 ( 4.2A)
SF4  B 502 (-2.5A)
None
None
None
 1.42A 3eigA-4yryB:
undetectable		 3eigA-4yryB:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmr EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine leukemia
virus;
Mus musculus) 		PF00075
(RNase_H)
PF03465
(eRF1_3) 		5 ILE B 294
ALA A 591
LEU A 621
GLU B 398
TYR A 586
 None
 1.43A 3eigA-5dmrB:
undetectable		 3eigA-5dmrB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxv RETHREADED DHFR

(synthetic
construct) 		PF00186
(DHFR_1) 		6 ILE A   5
ALA A   7
SER A  66
LEU A  71
ARG A  74
TYR A 117
 None
NAP  A 201 (-3.7A)
NAP  A 201 ( 4.9A)
None
None
None
 0.62A 3eigA-5dxvA:
12.0		 3eigA-5dxvA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 ILE A 288
ALA A 291
LEU A 336
PRO A 674
ASN A 649
 None
 1.30A 3eigA-5e9aA:
undetectable		 3eigA-5e9aA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewp ARO (ARMADILLO
REPEATS ONLY
PROTEIN)

(Plasmodium
falciparum) 		no annotation 5 ILE A  81
ALA A  83
LEU A 117
GLU A  53
ARG A  41
 None
 1.33A 3eigA-5ewpA:
undetectable		 3eigA-5ewpA:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fda DIHYDROFOLATE
REDUCTASE

(Yersinia pestis) 		PF00186
(DHFR_1) 		5 ILE A   6
ALA A   8
LEU A  55
ARG A  58
TYR A 101
 None
 1.19A 3eigA-5fdaA:
14.5		 3eigA-5fdaA:
31.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fda DIHYDROFOLATE
REDUCTASE

(Yersinia pestis) 		PF00186
(DHFR_1) 		5 ILE A   6
ALA A   8
SER A  50
LEU A  55
TYR A 101
 None
 0.59A 3eigA-5fdaA:
14.5		 3eigA-5fdaA:
31.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 ALA A2018
SER A2052
PRO A2050
ASN A2196
TYR A1982
 None
 1.42A 3eigA-5i6hA:
undetectable		 3eigA-5i6hA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 ILE L 453
GLU L 126
GLU L 210
PRO L 203
LEU L 193
 SF4  L 501 ( 4.4A)
SF4  L 501 (-2.3A)
None
None
None
 1.29A 3eigA-5jfcL:
undetectable		 3eigA-5jfcL:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 ILE A 698
LEU A 478
GLU A 683
SER A 472
PRO A 536
 None
 1.16A 3eigA-5l46A:
undetectable		 3eigA-5l46A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li8 PUTATIVE CYTOCHROME
P450 126

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 ILE A 158
LEU A 202
GLU A 256
PRO A 178
ARG A 259
 None
 0.83A 3eigA-5li8A:
undetectable		 3eigA-5li8A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 ILE A 557
ALA A 590
LEU A 454
GLU A 537
SER A 471
 None
 1.45A 3eigA-5neuA:
undetectable		 3eigA-5neuA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2d POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		no annotation 5 ILE A1112
LEU A1137
GLU A1146
PRO A1140
ASN A1142
 None
 1.32A 3eigA-5o2dA:
undetectable		 3eigA-5o2dA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oge GDP-MANNOSE
TRANSPORTER 1

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 265
SER A 102
ASN A  51
LEU A  55
TYR A 281
 None
 1.00A 3eigA-5ogeA:
undetectable		 3eigA-5ogeA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		7 ALA A  10
LEU A  23
SER A  86
PRO A  88
LEU A  94
ARG A  97
TYR A 157
 73X  A 704 (-4.0A)
None
NDP  A 702 (-3.8A)
73X  A 704 (-4.0A)
None
None
None
 0.60A 3eigA-5t0lA:
23.6		 3eigA-5t0lA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfe SYNAPTOTAGMIN-1

(Mus musculus) 		no annotation 5 ILE A 162
ALA A 227
GLU A 258
PRO A 246
LEU A 149
 None
 1.24A 3eigA-5vfeA:
undetectable		 3eigA-5vfeA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 5 ILE A 215
LEU A 266
GLU A 185
PRO A 336
ASN A 337
 None
 1.23A 3eigA-5xd6A:
undetectable		 3eigA-5xd6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
epidermidis) 		no annotation 5 ILE A 506
ALA A 530
SER A 441
LEU A 410
ARG A 413
 None
None
MG  A 802 ( 3.6A)
None
None
 1.19A 3eigA-5yjjA:
undetectable		 3eigA-5yjjA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2w PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN

(Campylobacter
jejuni) 		no annotation 5 ILE A 298
ALA A 292
LEU A 243
GLU A 283
PRO A 246
 None
 1.28A 3eigA-6b2wA:
undetectable		 3eigA-6b2wA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2w PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN

(Campylobacter
jejuni) 		no annotation 5 ILE A 298
ALA A 292
LEU A 243
PRO A 246
ASN A 281
 None
 1.19A 3eigA-6b2wA:
undetectable		 3eigA-6b2wA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3b APRA
METHYLTRANSFERASE 1

(Moorea
bouillonii) 		no annotation 5 LEU A 539
GLU A 550
PRO A 518
ASN A 519
LEU A 555
 None
 1.39A 3eigA-6b3bA:
undetectable		 3eigA-6b3bA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxm DIHYDROFOLATE
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 7 ILE A   6
ALA A   8
SER A  50
PRO A  52
LEU A  58
ARG A  61
TYR A  98
 MMV  A 202 (-4.0A)
NAP  A 201 (-3.9A)
NAP  A 201 ( 3.9A)
MMV  A 202 ( 4.6A)
MMV  A 202 (-4.2A)
MMV  A 202 (-2.8A)
None
 0.66A 3eigA-6cxmA:
19.6		 3eigA-6cxmA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gy6 -

(-) 		no annotation 5 ILE B  16
ALA B 301
LEU B 132
SER B  63
LEU B 339
 None
 1.09A 3eigA-6gy6B:
undetectable		 3eigA-6gy6B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT

(Escherichia
virus RB69) 		PF02916
(DNA_PPF)
PF09116
(gp45-slide_C) 		4 ASP A  46
ILE A  73
VAL A  52
THR A  31
 None
 1.13A 3eigA-1b8hA:
undetectable		 3eigA-1b8hA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01135
(PCMT) 		4 ARG A 273
ILE A 232
VAL A 267
THR A 257
 None
 1.19A 3eigA-1dl5A:
1.6		 3eigA-1dl5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 ARG A 315
ILE A 344
VAL A 182
THR A 215
 None
 1.19A 3eigA-1eu1A:
0.6		 3eigA-1eu1A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyw PHOSPHOTRIESTERASE

(Brevundimonas
diminuta) 		PF02126
(PTE) 		4 ASP A 253
ILE A 228
VAL A 198
THR A 103
 None
None
None
KCX  A 169 ( 4.3A)
 0.83A 3eigA-1eywA:
undetectable		 3eigA-1eywA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		4 ARG A  40
ILE A  42
VAL A 137
THR A  75
 None
 0.93A 3eigA-1j1wA:
undetectable		 3eigA-1j1wA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kuu CONSERVED PROTEIN

(Methanothermobacter) 		PF07826
(IMP_cyclohyd) 		4 ARG A   5
ILE A 113
VAL A  71
THR A  32
 None
 1.24A 3eigA-1kuuA:
undetectable		 3eigA-1kuuA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mky PROBABLE GTP-BINDING
PROTEIN ENGA

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 ASP A 347
ARG A 228
ILE A 225
THR A 357
 None
 1.25A 3eigA-1mkyA:
undetectable		 3eigA-1mkyA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mld MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ASP A  33
ILE A  12
VAL A  73
THR A 101
 None
 1.18A 3eigA-1mldA:
1.1		 3eigA-1mldA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 ASP A  96
ARG A  35
ILE A  63
VAL A  66
 DAN  A 700 (-3.3A)
DAN  A 700 (-3.0A)
None
None
 1.17A 3eigA-1ms8A:
undetectable		 3eigA-1ms8A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		4 ASP A 296
ARG A 262
ILE A 293
VAL A 331
 None
SO4  A2711 (-3.1A)
None
None
 1.23A 3eigA-1nhcA:
undetectable		 3eigA-1nhcA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgs PEPTIDE-N(4)-(N-ACET
YL-BETA-D-GLUCOSAMIN
YL)ASPARAGINE
AMIDASE F

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 ASP A 102
ILE A  98
VAL A  65
THR A 111
 None
 1.25A 3eigA-1pgsA:
undetectable		 3eigA-1pgsA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)

(Pseudomonas
mevalonii) 		PF00368
(HMG-CoA_red) 		4 ASP A 158
ILE A 138
VAL A 116
THR A 163
 None
 1.01A 3eigA-1qaxA:
undetectable		 3eigA-1qaxA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qni NITROUS-OXIDE
REDUCTASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 4 ASP A 245
ILE A 243
VAL A 124
THR A 119
 None
 1.20A 3eigA-1qniA:
undetectable		 3eigA-1qniA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1scj SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 ASP A  32
ILE A  72
VAL A 121
THR A 174
 None
None
None
CA  A 382 (-4.1A)
 1.18A 3eigA-1scjA:
undetectable		 3eigA-1scjA:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u70 DIHYDROFOLATE
REDUCTASE

(Mus musculus) 		PF00186
(DHFR_1) 		4 ASP A  21
ILE A  60
VAL A 115
THR A 136
 None
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.83A 3eigA-1u70A:
30.3		 3eigA-1u70A:
88.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF01634
(HisG) 		4 ASP A 104
ARG A 110
ILE A 108
VAL A 152
 None
 1.08A 3eigA-1ve4A:
undetectable		 3eigA-1ve4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vh1 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Escherichia
coli) 		PF02348
(CTP_transf_3) 		4 ASP A 100
ILE A 104
VAL A   5
THR A  76
 None
 1.22A 3eigA-1vh1A:
1.6		 3eigA-1vh1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 ASP A 123
ARG A 139
ILE A 136
VAL A  93
 None
 1.20A 3eigA-1wpqA:
undetectable		 3eigA-1wpqA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 320
ARG A 256
ILE A 251
VAL A 259
 None
 1.24A 3eigA-1zpuA:
undetectable		 3eigA-1zpuA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 ASP B 256
ILE B 240
VAL B 291
THR B 301
 None
 1.23A 3eigA-2afhB:
undetectable		 3eigA-2afhB:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		4 ARG A  38
ILE A  40
VAL A 135
THR A  73
 None
 1.02A 3eigA-2b0tA:
2.1		 3eigA-2b0tA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgh VINORINE SYNTHASE

(Rauvolfia
serpentina) 		PF02458
(Transferase) 		4 ASP A 303
ILE A 257
VAL A 272
THR A 319
 None
 1.21A 3eigA-2bghA:
undetectable		 3eigA-2bghA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE

(Pyrococcus
horikoshii) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ASP A  71
ARG A  74
ILE A  81
VAL A  89
 None
NAD  A2503 ( 4.4A)
None
None
 1.17A 3eigA-2dvmA:
undetectable		 3eigA-2dvmA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 ASP A 148
ILE A 292
VAL A 131
THR A 175
 None
 1.19A 3eigA-2i14A:
undetectable		 3eigA-2i14A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jeo URIDINE-CYTIDINE
KINASE 1

(Homo sapiens) 		PF00485
(PRK) 		4 ASP A  65
ILE A  61
VAL A  28
THR A 160
 None
 1.10A 3eigA-2jeoA:
2.2		 3eigA-2jeoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzn MANNOSE-SPECIFIC
PHOSPHOTRANSFERASE
ENZYME IIA COMPONENT

(Escherichia
coli) 		PF03610
(EIIA-man) 		4 ASP A  83
ARG A  79
ILE A  80
VAL A  89
 None
 1.08A 3eigA-2jznA:
undetectable		 3eigA-2jznA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqh PUTATIVE ISOMERASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 218
ILE A 241
VAL A 196
THR A 131
 None
 1.16A 3eigA-2oqhA:
undetectable		 3eigA-2oqhA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE

(Lactobacillus
plantarum) 		PF01643
(Acyl-ACP_TE) 		4 ASP A 185
ILE A  34
VAL A 206
THR A 235
 None
 1.10A 3eigA-2ownA:
undetectable		 3eigA-2ownA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8v HOMER PROTEIN
HOMOLOG 3

(Homo sapiens) 		PF00568
(WH1) 		4 ASP A  85
ARG A  52
ILE A  53
VAL A 112
 None
 1.23A 3eigA-2p8vA:
undetectable		 3eigA-2p8vA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ASP A1391
ARG A1017
ILE A1319
VAL A1404
THR A1528
 None
 1.46A 3eigA-2pffA:
undetectable		 3eigA-2pffA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvt GLUTAMATE RACEMASE

(Enterococcus
faecalis) 		PF01177
(Asp_Glu_race) 		4 ARG A 102
ILE A  97
VAL A 115
THR A 108
 None
 1.14A 3eigA-2vvtA:
3.1		 3eigA-2vvtA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ASP A 181
ARG A 187
VAL A  86
THR A  11
 None
None
EDO  A1510 (-4.6A)
GOL  A1511 ( 4.8A)
 1.09A 3eigA-2w40A:
undetectable		 3eigA-2w40A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yuo RUN AND TBC1 DOMAIN
CONTAINING 3

(Mus musculus) 		PF00018
(SH3_1) 		4 ASP A  63
ARG A   9
ILE A  34
VAL A  59
 None
 1.17A 3eigA-2yuoA:
undetectable		 3eigA-2yuoA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT ALPHA
NITRILE HYDRATASE
SUBUNIT BETA

(Rhodococcus
erythropolis) 		PF02211
(NHase_beta)
PF02979
(NHase_alpha) 		4 ASP A 161
ARG A 167
ILE A 107
THR B 157
 None
CSO  A 114 ( 3.8A)
None
None
 1.15A 3eigA-2zpbA:
undetectable		 3eigA-2zpbA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN

(Aequorea
victoria;
Mus musculus) 		PF00240
(ubiquitin)
PF01353
(GFP) 		4 ASP A 180
ARG A 168
ILE A 167
VAL A 150
 None
 1.12A 3eigA-3ai5A:
undetectable		 3eigA-3ai5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b13 DEDICATOR OF
CYTOKINESIS PROTEIN
2

(Homo sapiens) 		PF06920
(DHR-2) 		4 ASP A1341
ARG A1480
VAL A1345
THR A1471
 None
 1.24A 3eigA-3b13A:
undetectable		 3eigA-3b13A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF00535
(Glycos_transf_2) 		4 ASP A  68
ARG A  95
ILE A  63
VAL A 103
 None
 1.20A 3eigA-3cknA:
1.5		 3eigA-3cknA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		4 ASP A 250
ARG A 194
ILE A 191
VAL A 243
 None
 1.08A 3eigA-3cnnA:
2.2		 3eigA-3cnnA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpr DIHYDRODIPICOLINATE
SYNTHETASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		4 ASP A 177
ILE A 158
VAL A 117
THR A  59
 None
None
None
MCL  A 176 ( 3.9A)
 1.03A 3eigA-3cprA:
undetectable		 3eigA-3cprA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e74 ALLANTOINASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 ARG A 428
ILE A 448
VAL A  56
THR A 425
 None
 1.23A 3eigA-3e74A:
undetectable		 3eigA-3e74A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehf SENSOR KINASE (YOCF
PROTEIN)

(Bacillus
subtilis) 		PF07730
(HisKA_3) 		4 ASP A 321
ARG A 304
VAL A 291
THR A 362
 None
 1.23A 3eigA-3ehfA:
undetectable		 3eigA-3ehfA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		4 ASP A 570
ILE A 190
VAL A 557
THR A 602
 None
 0.92A 3eigA-3i04A:
undetectable		 3eigA-3i04A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k32 UNCHARACTERIZED
PROTEIN MJ0690

(Methanocaldococcus
jannaschii) 		no annotation 4 ASP A 165
ARG A 171
ILE A 170
VAL A  39
 None
 0.94A 3eigA-3k32A:
undetectable		 3eigA-3k32A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 ASP A 492
ARG A 280
ILE A 283
VAL A 496
 None
 1.19A 3eigA-3kjrA:
22.1		 3eigA-3kjrA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lua RESPONSE REGULATOR
RECEIVER PROTEIN

(Ruminiclostridium
thermocellum) 		PF00072
(Response_reg) 		4 ASP A   2
ILE A  25
VAL A 122
THR A  80
 None
 1.24A 3eigA-3luaA:
undetectable		 3eigA-3luaA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwn KINESIN-LIKE PROTEIN
KIF9

(Homo sapiens) 		PF00225
(Kinesin) 		4 ASP A 245
ARG A  12
ILE A 115
VAL A 312
 MG  A 402 ( 4.0A)
ADP  A 401 (-3.5A)
None
None
 1.22A 3eigA-3nwnA:
undetectable		 3eigA-3nwnA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on9 TUMOUR NECROSIS
FACTOR RECEPTOR

(Ectromelia
virus) 		PF07190
(DUF1406) 		4 ASP A 167
ILE A 170
VAL A 270
THR A 258
 None
 1.08A 3eigA-3on9A:
undetectable		 3eigA-3on9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on9 TUMOUR NECROSIS
FACTOR RECEPTOR

(Ectromelia
virus) 		PF07190
(DUF1406) 		4 ASP A 167
ILE A 170
VAL A 270
THR A 259
 None
 1.14A 3eigA-3on9A:
undetectable		 3eigA-3on9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 ARG A  96
ILE A  97
VAL A 133
THR A 159
 EDO  A 187 (-3.5A)
None
COA  A2598 ( 4.5A)
None
 1.25A 3eigA-3owcA:
undetectable		 3eigA-3owcA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p28 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		4 ASP A 132
ARG A 120
ILE A 119
VAL A 102
 None
 1.07A 3eigA-3p28A:
undetectable		 3eigA-3p28A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 ASP B 538
ARG B 297
ILE B 541
THR B 139
 None
 1.12A 3eigA-3p8cB:
undetectable		 3eigA-3p8cB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r1j ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Mycobacterium
avium) 		PF02668
(TauD) 		4 ARG A 268
ILE A 269
VAL A 243
THR A 126
 None
 1.20A 3eigA-3r1jA:
undetectable		 3eigA-3r1jA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASP A  50
ILE A 107
VAL A 122
THR A  55
 None
None
None
GOL  A 501 (-4.3A)
 1.14A 3eigA-3ramA:
undetectable		 3eigA-3ramA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		4 ASP A  11
ILE A 246
VAL A   7
THR A 167
 None
 1.19A 3eigA-3rmjA:
undetectable		 3eigA-3rmjA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 ARG A 807
ILE A 808
VAL A 851
THR A 734
 None
 1.23A 3eigA-3sucA:
undetectable		 3eigA-3sucA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		4 ASP A 426
ILE A 140
VAL A 151
THR A  21
 None
 1.19A 3eigA-3tlmA:
undetectable		 3eigA-3tlmA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		4 ASP A 122
ILE A 162
VAL A 211
THR A 264
 None
 1.21A 3eigA-3whiA:
undetectable		 3eigA-3whiA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cad RAS AND A-FACTOR
CONVERTING ENZYME 1,
RCE1

(Methanococcus
maripaludis) 		PF02517
(Abi) 		4 ASP C 150
ARG C 145
ILE C 220
THR C  16
 None
 1.25A 3eigA-4cadC:
undetectable		 3eigA-4cadC:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cua BETA-GALACTOSIDASE

(Streptococcus
pneumoniae) 		no annotation 4 ARG A1621
ILE A1620
VAL A1638
THR A1633
 EDO  A2646 (-3.8A)
None
None
None
 1.18A 3eigA-4cuaA:
undetectable		 3eigA-4cuaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1j GLYCEROL KINASE

(Sinorhizobium
meliloti) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ASP A 204
ARG A 210
VAL A 108
THR A  35
 None
None
None
GOL  A 601 ( 4.9A)
 1.05A 3eigA-4e1jA:
undetectable		 3eigA-4e1jA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 ASP A 221
ARG A  14
ILE A  13
VAL A  90
 None
 1.24A 3eigA-4htgA:
undetectable		 3eigA-4htgA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgk THG1-LIKE
UNCHARACTERIZED
PROTEIN

(Bacillus
thuringiensis) 		PF04446
(Thg1) 		4 ASP A  75
ARG A  28
ILE A  29
VAL A  70
 MG  A 302 (-2.8A)
None
None
None
 1.25A 3eigA-4kgkA:
undetectable		 3eigA-4kgkA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		4 ASP A 132
ILE A 104
VAL A  91
THR A 294
 None
 1.20A 3eigA-4kzkA:
1.6		 3eigA-4kzkA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		4 ASP A 465
ILE A 467
VAL A 402
THR A 395
 None
 1.15A 3eigA-4mzdA:
undetectable		 3eigA-4mzdA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwv HIGH-AFFINITY
LEUCINE-SPECIFIC
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN, CHEMOTAXIS
PROTEIN CHEY

(Escherichia
coli;
Thermotoga
maritima) 		PF00072
(Response_reg)
PF13458
(Peripla_BP_6) 		4 ASP A 247
ILE A 253
VAL A 269
THR A 117
 None
 1.20A 3eigA-4qwvA:
undetectable		 3eigA-4qwvA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
TER94

(Drosophila
melanogaster) 		PF02359
(CDC48_N)
PF02933
(CDC48_2) 		4 ARG A 141
ILE A  67
VAL A 105
THR A 177
 None
 1.25A 3eigA-4rv0A:
undetectable		 3eigA-4rv0A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uar PROTEIN CBBY

(Rhodobacter
sphaeroides) 		PF13419
(HAD_2) 		4 ASP A 139
ILE A 109
VAL A 172
THR A  12
 None
 1.11A 3eigA-4uarA:
2.8		 3eigA-4uarA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wji PUTATIVE
CYCLOHEXADIENYL
DEHYDROGENASE AND
ADH PREPHENATE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02153
(PDH) 		4 ASP A  53
ILE A  24
VAL A  70
THR A  37
 None
None
None
NAP  A 301 (-3.1A)
 1.07A 3eigA-4wjiA:
1.4		 3eigA-4wjiA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		4 ASP A  79
ARG A  16
ILE A  81
THR A 150
 None
None
None
GLU  A 301 (-3.5A)
 1.19A 3eigA-4wxjA:
undetectable		 3eigA-4wxjA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcg THERMOSOME SUBUNIT
BETA

(Sulfolobus
solfataricus) 		PF00118
(Cpn60_TCP1) 		4 ASP B 252
ILE B 345
VAL B 300
THR B 337
 None
 1.18A 3eigA-4xcgB:
undetectable		 3eigA-4xcgB:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		4 ARG A 288
ILE A 264
VAL A 293
THR A 100
 SO4  A 402 (-3.0A)
None
None
None
 1.21A 3eigA-4yshA:
undetectable		 3eigA-4yshA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		4 ASP K  58
ILE K  68
VAL K  97
THR K 105
 None
 1.15A 3eigA-5anbK:
undetectable		 3eigA-5anbK:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 ASP A 507
ILE A 417
VAL A 403
THR A 544
 MG  A2160 (-3.6A)
None
None
None
 0.71A 3eigA-5aorA:
undetectable		 3eigA-5aorA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dum 65C6 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP H  55
ARG H  50
ILE H  58
VAL H  79
 None
 0.93A 3eigA-5dumH:
undetectable		 3eigA-5dumH:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		4 ASP A 584
ILE A 570
VAL A 515
THR A 592
 None
 0.98A 3eigA-5ey9A:
undetectable		 3eigA-5ey9A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D

(Aequorea
victoria;
Streptococcus
pyogenes) 		PF01353
(GFP)
PF13930
(Endonuclea_NS_2) 		4 ASP A 180
ARG A 168
ILE A 167
VAL A 150
 None
 1.25A 3eigA-5fguA:
undetectable		 3eigA-5fguA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin) 		4 ASP A 443
ILE A 463
VAL A 303
THR A 492
 None
 0.79A 3eigA-5fn4A:
undetectable		 3eigA-5fn4A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giu PROLINE DIPEPTIDASE

(Deinococcus
radiodurans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ASP A 203
ARG A 154
ILE A 201
VAL A 226
 None
 1.20A 3eigA-5giuA:
undetectable		 3eigA-5giuA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3e PUTATIVE
DEOXYRIBONUCLEASE-2

(Burkholderia
thailandensis) 		PF03265
(DNase_II) 		4 ASP A 108
ARG A 170
VAL A 104
THR A 184
 None
 1.16A 3eigA-5i3eA:
undetectable		 3eigA-5i3eA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA

(Bacillus
subtilis) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 ARG A  19
ILE A  87
VAL A  76
THR A  35
 None
 1.17A 3eigA-5iufA:
undetectable		 3eigA-5iufA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA

(Bacillus
subtilis) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 ASP A 102
ILE A  87
VAL A  76
THR A  35
 None
 1.08A 3eigA-5iufA:
undetectable		 3eigA-5iufA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtw COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 ASP B1029
ILE B1049
VAL B1085
THR B1305
 None
 1.08A 3eigA-5jtwB:
undetectable		 3eigA-5jtwB:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ket ALDO-KETO REDUCTASE
1

(Coptotermes
gestroi) 		PF00248
(Aldo_ket_red) 		4 ARG A 183
ILE A 173
VAL A 211
THR A   9
 None
 1.07A 3eigA-5ketA:
undetectable		 3eigA-5ketA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens) 		PF04858
(TH1) 		4 ASP B 321
ILE B 378
VAL B 325
THR B 285
 None
 1.18A 3eigA-5l3xB:
undetectable		 3eigA-5l3xB:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0k BETA-XYLANASE

(Cellulomonas
flavigena) 		no annotation 4 ASP A  39
ARG A  14
ILE A 262
VAL A 295
 None
 1.24A 3eigA-5m0kA:
undetectable		 3eigA-5m0kA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 4 ASP A 645
ILE A 598
VAL A 400
THR A 384
 None
 1.08A 3eigA-5nn8A:
undetectable		 3eigA-5nn8A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		4 ARG A 147
ILE A 222
VAL A 152
THR A 297
 None
HEM  A 600 ( 4.1A)
HEM  A 600 ( 4.6A)
None
 1.17A 3eigA-5o1mA:
undetectable		 3eigA-5o1mA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oar BETA-HEXOSAMINIDASE

(Aspergillus
oryzae) 		no annotation 4 ASP B 271
ILE B 400
VAL B 382
THR B 320
 None
 1.19A 3eigA-5oarB:
undetectable		 3eigA-5oarB:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot0 L-ASPARAGINASE

(Thermococcus
kodakarensis) 		no annotation 4 ASP A  48
ILE A  30
VAL A  80
THR A  91
 None
 1.22A 3eigA-5ot0A:
undetectable		 3eigA-5ot0A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td7 ZGC:55652

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 ARG A 463
ILE A 437
VAL A 445
THR A 457
 None
 1.21A 3eigA-5td7A:
undetectable		 3eigA-5td7A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tla UBIQUITIN-LIKE
PROTEIN ISG15

(Mus musculus) 		PF00240
(ubiquitin) 		4 ASP A  54
ARG A  44
VAL A  38
THR A  99
 None
 1.12A 3eigA-5tlaA:
undetectable		 3eigA-5tlaA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x49 PROBABLE XAA-PRO
AMINOPEPTIDASE 3

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 ASP A 118
ILE A 240
VAL A  97
THR A 223
 None
 0.86A 3eigA-5x49A:
undetectable		 3eigA-5x49A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 4 ARG A 273
ILE A 330
VAL A 345
THR A 227
 None
None
None
FAD  A 701 (-4.9A)
 1.25A 3eigA-5xmjA:
undetectable		 3eigA-5xmjA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 4 ASP A 131
ARG A 185
ILE A 126
VAL A 249
 None
FUM  A 502 (-3.2A)
None
None
 1.23A 3eigA-5xnzA:
undetectable		 3eigA-5xnzA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 ASP B 398
ARG B 250
ILE B 261
VAL B 393
 None
 1.20A 3eigA-5y3rB:
undetectable		 3eigA-5y3rB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7v -

(-) 		no annotation 4 ASP A  85
ARG A  59
VAL A  79
THR A  53
 None
 1.20A 3eigA-6c7vA:
undetectable		 3eigA-6c7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis) 		no annotation 4 ASP A 119
ILE A 274
VAL A 256
THR A  92
 None
 1.25A 3eigA-6co7A:
1.4		 3eigA-6co7A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfp VCA0883

(Vibrio cholerae) 		no annotation 4 ASP A 340
ILE A  91
VAL A 330
THR A 301
 None
 1.19A 3eigA-6dfpA:
undetectable		 3eigA-6dfpA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ewp CENTROSOMAL PROTEIN
OF 120 KDA

(Mus musculus) 		no annotation 4 ASP A 598
ILE A 596
VAL A 475
THR A 494
 None
 1.11A 3eigA-6ewpA:
undetectable		 3eigA-6ewpA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fi2 VEXL

(Achromobacter
denitrificans) 		no annotation 4 ASP A 165
ARG A 168
VAL A 196
THR A 147
 None
 1.14A 3eigA-6fi2A:
undetectable		 3eigA-6fi2A:
15.59