SIMILAR PATTERNS OF AMINO ACIDS FOR 3EEY_J_SAMJ300_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1) 		PF00082
(Peptidase_S8) 		5 GLY A  14
ASN A  17
ILE A  90
GLY A  78
HIS A  75
 None
 1.12A 3eeyJ-1dbiA:
undetectable		 3eeyJ-1dbiA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN

(Homo sapiens) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLY A 224
ILE A 307
GLY A 282
HIS A 286
LEU A 319
 FAD  A 599 (-3.6A)
None
None
FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
 1.13A 3eeyJ-1efvA:
3.0		 3eeyJ-1efvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyw PHOSPHOTRIESTERASE

(Brevundimonas
diminuta) 		PF02126
(PTE) 		5 ASP A 235
ILE A 228
GLY A 209
GLN A 212
LEU A 252
 None
 1.15A 3eeyJ-1eywA:
undetectable		 3eeyJ-1eywA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g61 TRANSLATION
INITIATION FACTOR 6

(Methanocaldococcus
jannaschii) 		PF01912
(eIF-6) 		5 THR A2113
GLY A2117
ASP A2115
GLY A2151
ASN A2066
 None
 1.20A 3eeyJ-1g61A:
undetectable		 3eeyJ-1g61A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		5 THR A 170
GLY A 172
ILE A 145
GLY A 144
LEU A 166
 None
 1.16A 3eeyJ-1i8dA:
undetectable		 3eeyJ-1i8dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 GLY A  95
ASN A  96
ILE A  62
GLY A 118
LEU A  94
 None
 1.12A 3eeyJ-1jftA:
2.4		 3eeyJ-1jftA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne2 HYPOTHETICAL PROTEIN
TA1320

(Thermoplasma
acidophilum) 		PF06325
(PrmA) 		5 GLY A  58
ASN A  59
ASP A  78
ILE A  79
ASN A 114
 None
 1.05A 3eeyJ-1ne2A:
14.3		 3eeyJ-1ne2A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 GLY A 541
ASP A 534
ASP A 219
GLY A 248
THR A 230
 None
 1.14A 3eeyJ-1ps9A:
undetectable		 3eeyJ-1ps9A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		5 THR A 468
GLY A 437
ASN A 518
ILE A 459
ASN A 467
 None
CA  A 914 ( 4.0A)
None
None
None
 0.57A 3eeyJ-1q5aA:
undetectable		 3eeyJ-1q5aA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A  66
ASP A 116
ILE A 207
GLY A 208
ASN A 158
 None
 0.85A 3eeyJ-1r3nA:
2.8		 3eeyJ-1r3nA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk1 COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		5 GLY A  30
ILE A 120
GLY A  67
LEU A 240
THR A  63
 None
 1.07A 3eeyJ-1tk1A:
undetectable		 3eeyJ-1tk1A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkl COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		5 GLY A  30
ILE A 120
GLY A  67
LEU A 240
THR A  63
 None
 1.02A 3eeyJ-1tklA:
undetectable		 3eeyJ-1tklA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uer SUPEROXIDE DISMUTASE

(Porphyromonas
gingivalis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ASN A  75
ILE A  64
GLY A  63
ASN A 144
LEU A  53
 None
 1.16A 3eeyJ-1uerA:
undetectable		 3eeyJ-1uerA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		5 GLY A 246
ASP A 244
ILE A 202
ASN A 277
LEU A 273
 None
None
None
BGC  A 382 (-3.7A)
None
 0.95A 3eeyJ-1up2A:
undetectable		 3eeyJ-1up2A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		5 GLY A  68
ASN A  69
ILE A 338
GLY A 339
LEU A  65
 None
 1.18A 3eeyJ-1upxA:
2.6		 3eeyJ-1upxA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		5 GLY A 119
ASP A 144
ILE A 116
GLY A 115
LEU A  96
 None
 1.02A 3eeyJ-1v4vA:
4.0		 3eeyJ-1v4vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE

(Thermotoga
maritima) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 GLY A 362
ILE A 400
GLY A 402
LEU A 392
THR A 357
 None
 1.01A 3eeyJ-2b8nA:
3.2		 3eeyJ-2b8nA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Homo sapiens) 		PF01869
(BcrAD_BadFG) 		5 GLY A  77
ASP A 107
ILE A 124
ASN A  36
THR A 127
 GLC  A1001 ( 4.6A)
GLC  A1001 (-2.9A)
GLC  A1001 (-4.0A)
None
ADP  A 470 (-3.3A)
 1.19A 3eeyJ-2ch6A:
undetectable		 3eeyJ-2ch6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN
ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		5 THR H  98
GLY H 102
GLY H 107
GLN H   6
LEU L  96
 None
 1.19A 3eeyJ-2d7tH:
undetectable		 3eeyJ-2d7tH:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE

(Pyrococcus
horikoshii) 		PF00390
(malic)
PF03949
(Malic_M) 		5 GLY A  63
ASN A  64
GLY A  54
LEU A 340
THR A 400
 None
None
MES  A2759 ( 3.7A)
None
None
 1.20A 3eeyJ-2dvmA:
5.2		 3eeyJ-2dvmA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 GLY A 214
ASN A 213
GLY A  81
GLN A  43
ASN A 220
 None
 0.92A 3eeyJ-2eb5A:
undetectable		 3eeyJ-2eb5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		5 THR A 334
GLY A 398
ASN A 397
GLY A 328
HIS A 323
 None
 1.18A 3eeyJ-2gduA:
undetectable		 3eeyJ-2gduA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLY A 196
ASN A  27
ILE A 211
GLY A 145
HIS A 119
 None
None
None
None
ZN  A 561 ( 3.1A)
 0.85A 3eeyJ-2it4A:
undetectable		 3eeyJ-2it4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kc2 TALIN-1

(Mus musculus) 		PF09379
(FERM_N) 		5 THR A 114
ASP A 110
ILE A 119
GLY A 120
LEU A  88
 None
 1.09A 3eeyJ-2kc2A:
undetectable		 3eeyJ-2kc2A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1w PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		5 GLY A  37
ASP A  32
ILE A  31
GLY A  30
THR A  76
 NAD  A 501 (-2.9A)
NAD  A 501 (-2.8A)
NAD  A 501 ( 4.8A)
None
NAD  A 501 (-4.5A)
 1.10A 3eeyJ-2q1wA:
7.4		 3eeyJ-2q1wA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 THR A 111
GLY A 109
GLY A 126
HIS A  53
LEU A 137
 None
None
None
FE  A 253 (-3.3A)
None
 1.15A 3eeyJ-2qedA:
undetectable		 3eeyJ-2qedA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rag DIPEPTIDASE

(Caulobacter
vibrioides) 		PF01244
(Peptidase_M19) 		5 THR A  52
GLY A 358
ASN A 281
ASP A  51
GLY A  92
 None
 1.13A 3eeyJ-2ragA:
undetectable		 3eeyJ-2ragA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 GLY A 225
ASP A 289
ILE A 212
GLY A 213
THR A 218
 None
 1.00A 3eeyJ-2x3kA:
undetectable		 3eeyJ-2x3kA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 THR A 435
ASP A 437
GLY A 380
LEU A 328
THR A  92
 None
 1.01A 3eeyJ-2xijA:
3.5		 3eeyJ-2xijA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 THR A 435
GLY A 380
ASN A 436
LEU A 328
THR A  92
 None
 1.16A 3eeyJ-2xijA:
3.5		 3eeyJ-2xijA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xme CTP-INOSITOL-1-PHOSP
HATE
CYTIDYLYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF12804
(NTP_transf_3) 		5 GLY A 174
ASP A 117
ASP A 172
ILE A 161
GLY A 162
 None
 0.97A 3eeyJ-2xmeA:
3.5		 3eeyJ-2xmeA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 THR A 671
GLY A 669
ILE A 702
HIS A 673
THR A 657
 None
 1.12A 3eeyJ-2xt6A:
2.2		 3eeyJ-2xt6A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		5 THR A 220
GLY A 222
ASP A 193
GLY A 273
ASN A 192
 AMP  A 502 (-3.4A)
AMP  A 502 (-3.5A)
None
None
None
 0.91A 3eeyJ-3b1rA:
3.0		 3eeyJ-3b1rA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 THR A 424
ASP A 393
ILE A 419
GLY A 420
LEU A 431
 None
 1.10A 3eeyJ-3dmyA:
undetectable		 3eeyJ-3dmyA:
15.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		6 ASN A  60
ASP A  52
ILE A  53
GLY A  80
GLN A  82
LEU A 102
 None
SAM  A 300 (-2.9A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
SAM  A 300 ( 3.8A)
 1.21A 3eeyJ-3eeyA:
35.7		 3eeyJ-3eeyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		12 THR A  28
GLY A  30
ASN A  31
ASP A  34
ASP A  52
ILE A  53
GLY A  80
HIS A  81
GLN A  82
ASN A  98
LEU A 102
THR A 111
 SAM  A 300 (-4.1A)
SAM  A 300 (-3.4A)
SAM  A 300 (-4.7A)
SAM  A 300 (-3.9A)
SAM  A 300 (-2.9A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.5A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 3.8A)
SAM  A 300 (-4.4A)
 0.22A 3eeyJ-3eeyA:
35.7		 3eeyJ-3eeyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbq CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13786
(DUF4179) 		5 THR A 105
ASP A  50
GLY A  83
HIS A 107
LEU A  76
 None
 1.11A 3eeyJ-3fbqA:
undetectable		 3eeyJ-3fbqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 THR A 128
GLY A 126
ILE A 117
GLY A 151
LEU A  92
 None
 1.07A 3eeyJ-3h2zA:
5.7		 3eeyJ-3h2zA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE

(Streptomyces
coelicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 122
ASP A 124
ILE A  58
GLY A 402
ASN A  83
 None
 1.11A 3eeyJ-3krtA:
5.0		 3eeyJ-3krtA:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lby PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1697C

(Streptococcus
mutans) 		PF06962
(rRNA_methylase) 		11 THR A  27
GLY A  29
ASN A  30
ASP A  33
ASP A  48
GLY A  75
HIS A  76
GLN A  77
ASN A  93
LEU A  97
THR A 106
 SAH  A4630 (-4.2A)
SAH  A4630 (-3.6A)
None
None
SAH  A4630 (-2.9A)
SAH  A4630 (-3.3A)
SAH  A4630 (-3.1A)
SAH  A4630 (-3.8A)
None
SAH  A4630 (-3.9A)
SAH  A4630 (-4.5A)
 0.52A 3eeyJ-3lbyA:
30.7		 3eeyJ-3lbyA:
44.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472

(Streptococcus
mutans) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 THR A 202
GLY A 204
ASP A 263
GLN A 293
ASN A 307
 SAH  A 385 (-3.9A)
SAH  A 385 (-3.4A)
SAH  A 385 (-2.8A)
SAH  A 385 (-3.1A)
SAH  A 385 (-4.3A)
 0.73A 3eeyJ-3ldgA:
11.1		 3eeyJ-3ldgA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ASP A 104
ILE A 140
GLY A 136
HIS A  75
ASN A  80
LEU A  70
 None
 1.50A 3eeyJ-3mi9A:
2.4		 3eeyJ-3mi9A:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		7 THR A  27
GLY A  29
ASN A  30
ASP A  48
GLY A  75
HIS A  76
ASN A  93
 None
 0.88A 3eeyJ-3mtiA:
27.2		 3eeyJ-3mtiA:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		7 THR A  27
GLY A  29
ASP A  33
ASP A  48
GLY A  75
HIS A  76
ASN A  93
 None
 0.46A 3eeyJ-3mtiA:
27.2		 3eeyJ-3mtiA:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 5 THR A 216
GLY A 198
ASN A 178
ASP A 196
GLY A 257
 None
CA  A 409 (-4.2A)
None
None
CA  A 412 (-4.3A)
 1.17A 3eeyJ-3p4gA:
undetectable		 3eeyJ-3p4gA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 ASN A 695
ILE A 519
GLY A 518
ASN A 688
THR A 676
 None
 1.14A 3eeyJ-3psfA:
2.5		 3eeyJ-3psfA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 GLY A 744
ASP A 256
ILE A 741
GLY A 740
HIS A 260
 None
 1.13A 3eeyJ-3qr1A:
undetectable		 3eeyJ-3qr1A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 THR A 406
GLY A 393
ASN A 398
ASP A 388
ASP A 405
 None
 1.08A 3eeyJ-3s9vA:
undetectable		 3eeyJ-3s9vA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae) 		PF00275
(EPSP_synthase) 		5 GLY A  20
ASP A 233
ILE A 235
GLY A 238
THR A 260
 None
 1.15A 3eeyJ-3sweA:
2.2		 3eeyJ-3sweA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdp FORMATE/NITRITE
TRANSPORTER

(Clostridioides
difficile) 		PF01226
(Form_Nir_trans) 		5 GLY A  93
ASN A  96
GLY A  85
ASN A  11
LEU A   6
 None
 1.19A 3eeyJ-3tdpA:
undetectable		 3eeyJ-3tdpA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		5 THR A 784
GLY A 849
ILE A 685
LEU A 845
THR A 719
 None
 1.16A 3eeyJ-3tsyA:
undetectable		 3eeyJ-3tsyA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubr CYTOCHROME C-552

(Shewanella
oneidensis) 		PF02335
(Cytochrom_C552) 		5 THR A 154
GLY A 156
ASP A 126
GLY A  90
ASN A 153
 None
HEC  A 472 (-4.0A)
None
HEC  A 473 ( 4.4A)
None
 1.07A 3eeyJ-3ubrA:
undetectable		 3eeyJ-3ubrA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voh CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		5 THR A 290
GLY A 254
GLY A 287
ASN A 291
LEU A 259
 None
 1.17A 3eeyJ-3vohA:
undetectable		 3eeyJ-3vohA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxy PUTATIVE
UNCHARACTERIZED
PROTEIN CSYB

(Aspergillus
oryzae) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 312
ILE A 345
GLY A 154
HIS A 377
LEU A 212
 COA  A 401 (-3.8A)
None
None
None
None
 1.18A 3eeyJ-3wxyA:
undetectable		 3eeyJ-3wxyA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 THR A 671
GLY A 669
ILE A 702
HIS A 673
THR A 657
 None
 1.12A 3eeyJ-3zhrA:
undetectable		 3eeyJ-3zhrA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmb GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 GLY A 150
ASN A  10
ILE A 107
LEU A   8
THR A  31
 None
 1.11A 3eeyJ-4bmbA:
undetectable		 3eeyJ-4bmbA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0z ANCILLARY PROTEIN 2

(Streptococcus
pyogenes) 		PF08341
(TED) 		5 GLY A 116
ILE A 128
GLY A 127
ASN A 122
LEU A 181
 None
 1.12A 3eeyJ-4c0zA:
undetectable		 3eeyJ-4c0zA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		5 GLY A 392
ASN A 390
ASP A 493
ASP A 311
GLN A 257
 None
EDO  A1590 (-4.6A)
None
None
None
 1.19A 3eeyJ-4c22A:
2.3		 3eeyJ-4c22A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF00037
(Fer4)
PF01058
(Oxidored_q6) 		5 GLY B 207
ILE B 254
GLY B 170
LEU B 235
THR B 232
 SF4  B1275 ( 4.0A)
SF4  B1275 ( 4.6A)
None
SF4  B1275 (-3.7A)
SF4  B1275 (-3.4A)
 1.12A 3eeyJ-4ci0B:
undetectable		 3eeyJ-4ci0B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw5 DFNA

(Bacillus
velezensis) 		PF03060
(NMO) 		5 THR A 356
GLY A 358
ILE A 361
GLY A 365
ASN A 384
 None
None
None
None
FMN  A1753 (-2.8A)
 1.02A 3eeyJ-4cw5A:
undetectable		 3eeyJ-4cw5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		5 THR A  37
GLY A 262
ASN A 263
ILE A 256
GLY A 253
 None
 1.17A 3eeyJ-4djiA:
undetectable		 3eeyJ-4djiA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		5 GLY B 165
ASP B 163
HIS B 117
GLN B 179
ASN B  70
 PO4  B 501 ( 3.8A)
PO4  B 504 (-2.8A)
None
None
PO4  B 501 (-4.6A)
 1.20A 3eeyJ-4i6mB:
undetectable		 3eeyJ-4i6mB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jd0 NUCLEOTIDYL
TRANSFERASE

(Thermotoga
maritima) 		PF00483
(NTP_transferase) 		5 GLY A 168
ASP A 166
ILE A 155
GLY A 156
ASN A  85
 1KH  A 301 (-3.4A)
1KH  A 301 ( 2.6A)
None
PO4  A 306 (-3.4A)
GOL  A 314 ( 2.9A)
 0.99A 3eeyJ-4jd0A:
undetectable		 3eeyJ-4jd0A:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		5 ASP A 157
ILE A  23
GLY A  27
ASN A 155
LEU A  14
 None
 1.11A 3eeyJ-4jhiA:
undetectable		 3eeyJ-4jhiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		6 GLY A 253
ASP A 377
ILE A 283
GLY A 281
LEU A 407
THR A 437
 None
None
NK  A 501 (-4.4A)
None
None
None
 1.29A 3eeyJ-4jz6A:
4.1		 3eeyJ-4jz6A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
ACETALDEHYDE
DEHYDROGENASE

(Thermomonospora
curvata;
Thermomonospora
curvata) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm)
PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		5 GLY A  60
ASP A  57
ASP A 102
GLN A 128
THR B 190
 None
 1.02A 3eeyJ-4lrsA:
undetectable		 3eeyJ-4lrsA:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis) 		PF06962
(rRNA_methylase) 		5 ASN A  31
ASP A  52
ILE A  53
LEU A 105
THR A 113
 SAM  A 301 (-4.5A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
None
 1.15A 3eeyJ-4pooA:
29.6		 3eeyJ-4pooA:
44.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis) 		PF06962
(rRNA_methylase) 		10 THR A  28
GLY A  30
ASN A  31
ASP A  34
ASP A  52
ILE A  53
HIS A  80
ASN A 101
LEU A 105
THR A 114
 SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
 0.46A 3eeyJ-4pooA:
29.6		 3eeyJ-4pooA:
44.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 THR A 223
GLY A 225
ASP A 196
GLY A 280
ASN A 195
 None
 1.06A 3eeyJ-4pvvA:
3.6		 3eeyJ-4pvvA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF17033
(Peptidase_M99)
PF17129
(Peptidase_M99_C)
PF17130
(Peptidase_M99_m) 		5 GLY A  51
ASN A  54
ASP A 129
GLY A 131
LEU A 229
 None
 1.06A 3eeyJ-4q6pA:
undetectable		 3eeyJ-4q6pA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF17033
(Peptidase_M99)
PF17129
(Peptidase_M99_C)
PF17130
(Peptidase_M99_m) 		5 GLY A  51
ASN A  54
ASP A 129
GLY A 149
LEU A 229
 None
 1.05A 3eeyJ-4q6pA:
undetectable		 3eeyJ-4q6pA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi3 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF16010
(CDH-cyt) 		5 THR A  19
ASN A   3
GLY A  53
ASN A   6
THR A  34
 None
PCA  A   1 ( 4.5A)
None
None
None
 1.02A 3eeyJ-4qi3A:
undetectable		 3eeyJ-4qi3A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		5 THR A 154
GLY A 223
ASP A 158
ILE A 315
LEU A 227
 None
 1.01A 3eeyJ-4rgqA:
undetectable		 3eeyJ-4rgqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 5 GLY B 188
ASN B 155
ILE B 424
GLY B 423
ASN B 270
 None
 1.11A 3eeyJ-4tqoB:
undetectable		 3eeyJ-4tqoB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A  20
ASN A  44
GLY A 130
ASN A  25
THR A 133
 PO4  A 401 (-3.3A)
PO4  A 401 ( 4.2A)
None
None
None
 1.13A 3eeyJ-4u39A:
4.4		 3eeyJ-4u39A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 GLY E 237
ASP E 233
GLY E 241
GLN E 145
ASN E 171
 None
 1.10A 3eeyJ-4v1dE:
undetectable		 3eeyJ-4v1dE:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w87 XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		5 GLY A 334
ASN A 333
ASP A 380
GLY A 383
THR A 341
 None
 1.20A 3eeyJ-4w87A:
undetectable		 3eeyJ-4w87A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 GLY A 442
ILE A 520
GLY A 522
HIS A 521
THR A 511
 EDO  A 706 ( 4.5A)
None
None
None
None
 1.17A 3eeyJ-4wd1A:
undetectable		 3eeyJ-4wd1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT
PUTATIVE
OXIDOREDUCTASE
IRON-SULFUR SUBUNIT

(Sulfurisphaera
tokodaii;
Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF00111
(Fer2)
PF01799
(Fer2_2) 		5 GLY C  53
ILE C 136
GLY C 135
ASN C  51
THR A 643
 FES  C 201 (-3.9A)
None
None
FAD  B 301 ( 4.2A)
None
 1.07A 3eeyJ-4zohC:
undetectable		 3eeyJ-4zohC:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ASP A 320
GLY A 162
HIS A 161
ASN A 192
THR A 265
 None
 0.96A 3eeyJ-5a05A:
3.2		 3eeyJ-5a05A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0l FIBRONECTIN-BINDING
PROTEIN

(Streptococcus
pyogenes) 		PF08341
(TED) 		5 GLY A 166
ILE A 178
GLY A 177
ASN A 172
LEU A 231
 None
 1.06A 3eeyJ-5a0lA:
undetectable		 3eeyJ-5a0lA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 THR A 635
GLY A 668
ASN A 669
ASP A 637
GLY A 632
 None
 1.13A 3eeyJ-5dkxA:
undetectable		 3eeyJ-5dkxA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		6 THR A 100
ILE A 114
GLY A 115
HIS A 116
ASN A 135
LEU A 105
 None
 1.49A 3eeyJ-5dldA:
4.1		 3eeyJ-5dldA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1

(Homo sapiens) 		PF05891
(Methyltransf_PK) 		5 GLY A  71
ASP A  91
ILE A  92
GLY A 118
GLN A 120
 SAH  A 301 (-3.1A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.4A)
 0.58A 3eeyJ-5e1bA:
10.5		 3eeyJ-5e1bA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxf ACRYLYL-COA
REDUCTASE ACUI

(Ruegeria
pomeroyi) 		PF00107
(ADH_zinc_N) 		5 THR A  41
GLY A 128
ASP A  67
ILE A  66
GLY A  65
 None
 1.11A 3eeyJ-5gxfA:
7.1		 3eeyJ-5gxfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzg GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 GLY A 150
ASN A  10
ILE A 107
LEU A   8
THR A  31
 None
 1.09A 3eeyJ-5gzgA:
undetectable		 3eeyJ-5gzgA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5j FERREDOXIN--NADP
REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1) 		5 GLY A 152
ASN A  27
ILE A  96
GLY A 110
HIS A  61
 None
 1.20A 3eeyJ-5h5jA:
2.7		 3eeyJ-5h5jA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASP A 125
ILE A 143
ASN A 124
LEU A 243
THR A 236
 None
 1.13A 3eeyJ-5j0aA:
undetectable		 3eeyJ-5j0aA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j60 THIOREDOXIN
REDUCTASE

(Gloeobacter
violaceus) 		PF07992
(Pyr_redox_2) 		5 ASP A 314
ILE A  10
GLY A  17
LEU A  29
THR A  77
 None
 1.07A 3eeyJ-5j60A:
2.9		 3eeyJ-5j60A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		5 GLY A  89
ILE A 155
GLY A 154
HIS A  80
LEU A  38
 None
 0.96A 3eeyJ-5l2pA:
undetectable		 3eeyJ-5l2pA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]

(Ruminococcus
flavefaciens) 		no annotation 5 THR B 102
ASN B  72
ASP B  74
GLY B  99
ASN B  78
 None
None
CA  B 201 (-3.1A)
None
None
 1.14A 3eeyJ-5m2sB:
undetectable		 3eeyJ-5m2sB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A 121
ILE A  88
GLY A  87
ASN A 138
LEU A 119
 None
 1.16A 3eeyJ-5n9xA:
2.9		 3eeyJ-5n9xA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-8

(Caenorhabditis
elegans) 		PF10220
(Smg8_Smg9) 		5 GLY E  64
ASP E   2
ILE E  41
GLY E  38
LEU E  73
 None
 1.03A 3eeyJ-5nkmE:
undetectable		 3eeyJ-5nkmE:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 169
ASP A 165
ILE A 123
GLY A 126
THR A 558
 None
 1.03A 3eeyJ-5tf0A:
undetectable		 3eeyJ-5tf0A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2i GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica) 		PF01112
(Asparaginase_2) 		5 GLY A  52
ASP A  44
GLY A 154
ASN A  87
LEU A  65
 None
 0.96A 3eeyJ-5v2iA:
undetectable		 3eeyJ-5v2iA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN

(Vibrio
vulnificus) 		no annotation 5 GLY A3895
ASP A4049
ILE A3898
GLY A3899
LEU A3890
 GLY  A3895 ( 0.0A)
ASP  A4049 ( 0.6A)
ILE  A3898 ( 0.7A)
GLY  A3899 ( 0.0A)
LEU  A3890 ( 0.6A)
 1.12A 3eeyJ-5w6lA:
undetectable		 3eeyJ-5w6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgz BETA-GLYCOSIDASE

(uncultured
microorganism) 		no annotation 5 ASP A 152
GLY A 223
ASN A 215
LEU A 158
THR A 220
 None
 1.06A 3eeyJ-5xgzA:
undetectable		 3eeyJ-5xgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		no annotation 5 ASP A 108
ILE A  49
ASN A 109
LEU A 104
THR A  40
 MG  A 302 ( 2.5A)
None
DAU  A 301 (-3.2A)
None
None
 1.00A 3eeyJ-6b5eA:
undetectable		 3eeyJ-6b5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis) 		no annotation 5 ASP A 220
ILE A 214
GLY A 243
HIS A 241
LEU A 255
 None
 1.18A 3eeyJ-6co7A:
undetectable		 3eeyJ-6co7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 5 ASN A1421
ASP A1374
ILE A1414
GLY A1376
THR A1382
 None
 1.02A 3eeyJ-6fb3A:
undetectable		 3eeyJ-6fb3A:
undetectable