SIMILAR PATTERNS OF AMINO ACIDS FOR 3EEY_I_SAMI300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		5 GLY A 138
ASN A 126
ASN A 128
ILE A 175
GLY A 200
 None
 1.11A 3eeyI-1ajoA:
undetectable		 3eeyI-1ajoA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		5 GLY A 389
ASN A 377
ASN A 379
ILE A  29
GLY A  54
 None
 1.10A 3eeyI-1axkA:
undetectable		 3eeyI-1axkA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE
PENICILLIN G AMIDASE

(Providencia
rettgeri;
Providencia
rettgeri) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		5 GLY B  39
ASN A  20
ASP A  21
ILE B  44
GLY B 158
 None
 1.17A 3eeyI-1cp9B:
undetectable		 3eeyI-1cp9B:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1) 		PF00082
(Peptidase_S8) 		5 GLY A  14
ASN A  17
ILE A  90
GLY A  78
HIS A  75
 None
 1.13A 3eeyI-1dbiA:
undetectable		 3eeyI-1dbiA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN

(Homo sapiens) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLY A 224
ILE A 307
GLY A 282
HIS A 286
LEU A 319
 FAD  A 599 (-3.6A)
None
None
FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
 1.17A 3eeyI-1efvA:
3.4		 3eeyI-1efvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 GLY A  95
ASN A  96
ILE A  62
GLY A 118
LEU A  94
 None
 1.11A 3eeyI-1jftA:
undetectable		 3eeyI-1jftA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		5 THR A  25
ASN A  21
ASP A  23
ILE A  55
LEU A  32
 None
 1.08A 3eeyI-1ktnA:
undetectable		 3eeyI-1ktnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Salmonella
enterica) 		PF00483
(NTP_transferase) 		5 ASP A 111
ILE A  52
ASN A 112
LEU A 107
THR A  43
 TTP  A 501 (-3.2A)
None
None
None
None
 1.17A 3eeyI-1mp3A:
undetectable		 3eeyI-1mp3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		5 THR A 468
GLY A 437
ASN A 518
ILE A 459
ASN A 467
 None
CA  A 914 ( 4.0A)
None
None
None
 0.56A 3eeyI-1q5aA:
undetectable		 3eeyI-1q5aA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A  66
ASP A 116
ILE A 207
GLY A 208
ASN A 158
 None
 0.87A 3eeyI-1r3nA:
undetectable		 3eeyI-1r3nA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ASN A 375
ASN A 373
ILE A 851
GLY A 850
LEU A 708
 None
 1.10A 3eeyI-1rrhA:
undetectable		 3eeyI-1rrhA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		5 GLY A  68
ASN A  69
ILE A 338
GLY A 339
LEU A  65
 None
 1.09A 3eeyI-1upxA:
2.5		 3eeyI-1upxA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		5 GLY A 119
ASP A 144
ILE A 116
GLY A 115
LEU A  96
 None
 0.97A 3eeyI-1v4vA:
4.0		 3eeyI-1v4vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 GLY A 288
ASN A 260
ASN A 262
ILE A 283
GLY A 282
 None
 1.15A 3eeyI-1z8lA:
undetectable		 3eeyI-1z8lA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE

(Thermotoga
maritima) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 GLY A 362
ILE A 400
GLY A 402
LEU A 392
THR A 357
 None
 1.11A 3eeyI-2b8nA:
3.5		 3eeyI-2b8nA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN
ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		5 THR H  98
GLY H 102
GLY H 107
GLN H   6
LEU L  96
 None
 1.17A 3eeyI-2d7tH:
undetectable		 3eeyI-2d7tH:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE

(Pyrococcus
horikoshii) 		PF00390
(malic)
PF03949
(Malic_M) 		5 GLY A  63
ASN A  64
GLY A  54
LEU A 340
THR A 400
 None
None
MES  A2759 ( 3.7A)
None
None
 1.15A 3eeyI-2dvmA:
5.3		 3eeyI-2dvmA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 GLY A 214
ASN A 213
GLY A  81
GLN A  43
ASN A 220
 None
 0.92A 3eeyI-2eb5A:
undetectable		 3eeyI-2eb5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ASN A 203
ASN A 181
ILE A 248
GLY A 329
THR A 218
 None
 1.11A 3eeyI-2f7lA:
undetectable		 3eeyI-2f7lA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Lupinus luteus;
Lupinus luteus) 		PF01112
(Asparaginase_2)
PF01112
(Asparaginase_2) 		5 THR B 193
GLY A  10
GLY A  68
LEU A   8
THR B 209
 None
None
NA  A 401 ( 4.6A)
None
None
 1.16A 3eeyI-2gezB:
undetectable		 3eeyI-2gezB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		5 THR A 242
ASN A 277
ASP A 390
ILE A 213
GLY A 161
 BSC  A   2 (-3.7A)
None
None
None
None
 1.17A 3eeyI-2gwcA:
undetectable		 3eeyI-2gwcA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus) 		no annotation 5 THR A 250
GLY A 179
ASN A 178
ASN A 258
GLY A 187
 None
 1.17A 3eeyI-2hihA:
undetectable		 3eeyI-2hihA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrb CARBONYL REDUCTASE
[NADPH] 3

(Homo sapiens) 		PF00106
(adh_short) 		5 THR A  11
ASN A  14
ILE A  70
ASN A  90
THR A 118
 None
NAP  A1001 (-3.1A)
None
NAP  A1001 (-3.3A)
None
 1.18A 3eeyI-2hrbA:
9.4		 3eeyI-2hrbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLY A 196
ASN A  27
ILE A 211
GLY A 145
HIS A 119
 None
None
None
None
ZN  A 561 ( 3.1A)
 0.84A 3eeyI-2it4A:
undetectable		 3eeyI-2it4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kc2 TALIN-1

(Mus musculus) 		PF09379
(FERM_N) 		5 THR A 114
ASP A 110
ILE A 119
GLY A 120
LEU A  88
 None
 1.11A 3eeyI-2kc2A:
undetectable		 3eeyI-2kc2A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ory LIPASE

(Photobacterium
sp. M37) 		PF01764
(Lipase_3) 		5 THR A 210
GLY A 212
ASN A 213
GLY A 177
ASN A 243
 None
 1.16A 3eeyI-2oryA:
undetectable		 3eeyI-2oryA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3l UNCHARACTERIZED
PROTEIN

(Shewanella
loihica) 		PF11964
(SpoIIAA-like) 		5 GLY A  27
ASN A   4
ILE A  59
GLY A  91
LEU A  29
 None
None
MPD  A 129 ( 4.8A)
None
None
 1.14A 3eeyI-2q3lA:
undetectable		 3eeyI-2q3lA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 GLY A 225
ASP A 289
ILE A 212
GLY A 213
THR A 218
 None
 0.99A 3eeyI-2x3kA:
undetectable		 3eeyI-2x3kA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 GLY A 316
ASN A  14
ILE A 270
GLY A 131
GLN A 134
 None
 1.14A 3eeyI-2xf8A:
2.3		 3eeyI-2xf8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		6 THR A 435
ASP A 437
GLY A 380
ASN A 436
LEU A 328
THR A  92
 None
 1.19A 3eeyI-2xijA:
2.5		 3eeyI-2xijA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		5 THR A 220
GLY A 222
ASP A 193
GLY A 273
ASN A 192
 AMP  A 502 (-3.4A)
AMP  A 502 (-3.5A)
None
None
None
 0.90A 3eeyI-3b1rA:
3.3		 3eeyI-3b1rA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 THR A 424
ASP A 393
ILE A 419
GLY A 420
LEU A 431
 None
 1.10A 3eeyI-3dmyA:
undetectable		 3eeyI-3dmyA:
15.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		5 ASN A  60
ILE A  53
GLY A  80
GLN A  82
LEU A 102
 None
SAM  A 300 (-4.0A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
SAM  A 300 ( 3.8A)
 1.09A 3eeyI-3eeyA:
35.6		 3eeyI-3eeyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		12 THR A  28
GLY A  30
ASN A  31
ASN A  33
ASP A  34
ILE A  53
GLY A  80
HIS A  81
GLN A  82
ASN A  98
LEU A 102
THR A 111
 SAM  A 300 (-4.1A)
SAM  A 300 (-3.4A)
SAM  A 300 (-4.7A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.9A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.5A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 3.8A)
SAM  A 300 (-4.4A)
 0.24A 3eeyI-3eeyA:
35.6		 3eeyI-3eeyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbq CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13786
(DUF4179) 		5 THR A 105
ASP A  50
GLY A  83
HIS A 107
LEU A  76
 None
 1.03A 3eeyI-3fbqA:
undetectable		 3eeyI-3fbqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmj PROTEIN MOTHERS
AGAINST DPP

(Drosophila
melanogaster) 		no annotation 5 ASN D 294
ILE D 320
GLY D 323
ASN D 291
LEU D 304
 None
 1.16A 3eeyI-3gmjD:
undetectable		 3eeyI-3gmjD:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 THR A 128
GLY A 126
ILE A 117
GLY A 151
LEU A  92
 None
 1.09A 3eeyI-3h2zA:
5.5		 3eeyI-3h2zA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Desulfovibrio
vulgaris) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 453
ASN A 454
ASN A 458
ILE A 401
GLY A 400
 None
 1.18A 3eeyI-3iwaA:
2.3		 3eeyI-3iwaA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE

(Streptomyces
coelicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 122
ASP A 124
ILE A  58
GLY A 402
ASN A  83
 None
 1.14A 3eeyI-3krtA:
5.3		 3eeyI-3krtA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 GLY A 757
ASN A 781
ASP A 458
ILE A 420
LEU A 760
 None
 1.09A 3eeyI-3la4A:
undetectable		 3eeyI-3la4A:
13.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lby PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1697C

(Streptococcus
mutans) 		PF06962
(rRNA_methylase) 		6 THR A  27
ASN A  30
GLY A  75
HIS A  76
GLN A  77
THR A 106
 SAH  A4630 (-4.2A)
None
SAH  A4630 (-3.3A)
SAH  A4630 (-3.1A)
SAH  A4630 (-3.8A)
SAH  A4630 (-4.5A)
 1.12A 3eeyI-3lbyA:
31.0		 3eeyI-3lbyA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lby PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1697C

(Streptococcus
mutans) 		PF06962
(rRNA_methylase) 		10 THR A  27
GLY A  29
ASN A  30
ASN A  32
ASP A  33
GLY A  75
HIS A  76
GLN A  77
ASN A  93
THR A 106
 SAH  A4630 (-4.2A)
SAH  A4630 (-3.6A)
None
None
None
SAH  A4630 (-3.3A)
SAH  A4630 (-3.1A)
SAH  A4630 (-3.8A)
None
SAH  A4630 (-4.5A)
 0.41A 3eeyI-3lbyA:
31.0		 3eeyI-3lbyA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lby PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1697C

(Streptococcus
mutans) 		PF06962
(rRNA_methylase) 		10 THR A  27
GLY A  29
ASN A  30
ASN A  32
ASP A  33
GLY A  75
HIS A  76
GLN A  77
LEU A  97
THR A 106
 SAH  A4630 (-4.2A)
SAH  A4630 (-3.6A)
None
None
None
SAH  A4630 (-3.3A)
SAH  A4630 (-3.1A)
SAH  A4630 (-3.8A)
SAH  A4630 (-3.9A)
SAH  A4630 (-4.5A)
 0.62A 3eeyI-3lbyA:
31.0		 3eeyI-3lbyA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		5 THR A  27
GLY A  29
ASN A  30
GLY A  75
HIS A  76
 None
 0.91A 3eeyI-3mtiA:
27.2		 3eeyI-3mtiA:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		7 THR A  27
GLY A  29
ASN A  32
ASP A  33
GLY A  75
HIS A  76
ASN A  93
 None
 0.56A 3eeyI-3mtiA:
27.2		 3eeyI-3mtiA:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		5 GLY A 393
ASN A 389
ILE A 416
GLY A 412
LEU A 423
 None
 1.06A 3eeyI-3n71A:
undetectable		 3eeyI-3n71A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		5 GLY A 393
ASN A 389
ILE A 416
GLY A 414
LEU A 423
 None
 1.17A 3eeyI-3n71A:
undetectable		 3eeyI-3n71A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		5 THR A 276
GLY A 169
ASN A 262
ILE A 152
GLY A 148
 None
 0.94A 3eeyI-3oqbA:
3.8		 3eeyI-3oqbA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 5 THR A 216
GLY A 198
ASN A 178
ASP A 196
GLY A 257
 None
CA  A 409 (-4.2A)
None
None
CA  A 412 (-4.3A)
 1.17A 3eeyI-3p4gA:
undetectable		 3eeyI-3p4gA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 ASN A 695
ILE A 519
GLY A 518
ASN A 688
THR A 676
 None
 1.15A 3eeyI-3psfA:
2.3		 3eeyI-3psfA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 GLY A 744
ASP A 256
ILE A 741
GLY A 740
HIS A 260
 None
 1.14A 3eeyI-3qr1A:
undetectable		 3eeyI-3qr1A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t57 UDP-N-ACETYLGLUCOSAM
INE
O-ACYLTRANSFERASE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 GLY A 143
ASN A 144
ASN A 145
GLY A 124
ASN A 170
 None
 1.18A 3eeyI-3t57A:
undetectable		 3eeyI-3t57A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacteroides
abscessus) 		PF01182
(Glucosamine_iso) 		6 GLY A  71
ASN A 155
ASP A  73
ILE A  39
ASN A  84
LEU A 146
 None
 1.35A 3eeyI-3tx2A:
4.9		 3eeyI-3tx2A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubr CYTOCHROME C-552

(Shewanella
oneidensis) 		PF02335
(Cytochrom_C552) 		5 THR A 154
GLY A 156
ASP A 126
GLY A  90
ASN A 153
 None
HEC  A 472 (-4.0A)
None
HEC  A 473 ( 4.4A)
None
 1.09A 3eeyI-3ubrA:
undetectable		 3eeyI-3ubrA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v3t CELL DIVISION GTPASE
FTSZ, DIVERGED

(Clostridium
botulinum) 		PF00091
(Tubulin) 		5 GLY A  15
ASN A  16
ASN A 174
ILE A  33
THR A 105
 None
 1.02A 3eeyI-3v3tA:
5.4		 3eeyI-3v3tA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voh CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		5 THR A 290
GLY A 254
GLY A 287
ASN A 291
LEU A 259
 None
 1.14A 3eeyI-3vohA:
undetectable		 3eeyI-3vohA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A

(Saccharomyces
cerevisiae) 		PF16787
(NDC10_II) 		5 ASN A 143
ILE A 126
GLY A 127
ASN A 145
THR A 148
 None
 1.16A 3eeyI-4acoA:
undetectable		 3eeyI-4acoA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au0 EXOGLUCANASE 2

(Trichoderma
reesei) 		PF01341
(Glyco_hydro_6) 		5 THR A 301
GLY A 265
GLY A 298
ASN A 302
LEU A 270
 None
 1.18A 3eeyI-4au0A:
undetectable		 3eeyI-4au0A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw5 DFNA

(Bacillus
velezensis) 		PF03060
(NMO) 		5 THR A 356
GLY A 358
ILE A 361
GLY A 365
ASN A 384
 None
None
None
None
FMN  A1753 (-2.8A)
 1.04A 3eeyI-4cw5A:
undetectable		 3eeyI-4cw5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1e ALPHA-ACTININ-2

(Homo sapiens) 		PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen) 		5 GLY A 185
ASN A 170
ILE A 245
GLN A  39
ASN A 211
 None
 1.11A 3eeyI-4d1eA:
undetectable		 3eeyI-4d1eA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		5 THR A  37
GLY A 262
ASN A 263
ILE A 256
GLY A 253
 None
 1.17A 3eeyI-4djiA:
undetectable		 3eeyI-4djiA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6u ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 GLY A  86
ASN A  87
ASN A  88
GLY A  68
ASN A 114
 None
 1.15A 3eeyI-4e6uA:
undetectable		 3eeyI-4e6uA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqn SPOROZOITE SURFACE
PROTEIN 2

(Plasmodium
vivax) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 THR A 127
GLY A  90
ILE A  55
LEU A  88
THR A 157
 MN  A 301 ( 2.7A)
None
None
None
None
 1.17A 3eeyI-4hqnA:
2.4		 3eeyI-4hqnA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		6 THR A 847
ASN A 851
ASP A 849
ILE A 886
GLY A 882
LEU A 896
 None
 1.49A 3eeyI-4i2wA:
undetectable		 3eeyI-4i2wA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		5 THR A  54
GLY A  56
ASN A  58
ILE A  49
GLY A  50
 None
NO3  A 604 ( 4.2A)
NO3  A 604 (-4.3A)
None
None
 1.08A 3eeyI-4i8vA:
undetectable		 3eeyI-4i8vA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Sinorhizobium
meliloti) 		PF04452
(Methyltrans_RNA) 		5 GLY A 108
ASP A  82
ILE A 144
GLY A  49
LEU A 110
 None
 1.15A 3eeyI-4j3cA:
undetectable		 3eeyI-4j3cA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		5 ASP A 157
ILE A  23
GLY A  27
ASN A 155
LEU A  14
 None
 1.15A 3eeyI-4jhiA:
undetectable		 3eeyI-4jhiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF05431
(Toxin_10) 		6 THR A 335
GLY A 234
ASN A 338
ASP A 337
ILE A 237
GLN A 332
 None
 1.36A 3eeyI-4jp0A:
undetectable		 3eeyI-4jp0A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 GLY A 253
ASP A 377
ILE A 283
GLY A 281
THR A 437
 None
None
NK  A 501 (-4.4A)
None
None
 1.09A 3eeyI-4jz6A:
4.2		 3eeyI-4jz6A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
oryzae) 		PF01156
(IU_nuc_hydro) 		5 THR A 236
GLY A 234
ASN A 280
ASN A 281
GLY A 212
 None
None
CA  A 501 ( 4.5A)
None
None
 1.10A 3eeyI-4kl0A:
4.3		 3eeyI-4kl0A:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis) 		PF06962
(rRNA_methylase) 		9 THR A  28
GLY A  30
ASN A  31
ASP A  34
ILE A  53
HIS A  80
ASN A 101
LEU A 105
THR A 114
 SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
 0.49A 3eeyI-4pooA:
29.9		 3eeyI-4pooA:
44.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 THR A 223
GLY A 225
ASP A 196
GLY A 280
ASN A 195
 None
 1.06A 3eeyI-4pvvA:
3.7		 3eeyI-4pvvA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi3 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF16010
(CDH-cyt) 		5 THR A  19
ASN A   3
GLY A  53
ASN A   6
THR A  34
 None
PCA  A   1 ( 4.5A)
None
None
None
 1.04A 3eeyI-4qi3A:
undetectable		 3eeyI-4qi3A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 5 GLY B 188
ASN B 155
ILE B 424
GLY B 423
ASN B 270
 None
 1.11A 3eeyI-4tqoB:
undetectable		 3eeyI-4tqoB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A  20
ASN A  44
GLY A 130
ASN A  25
THR A 133
 PO4  A 401 (-3.3A)
PO4  A 401 ( 4.2A)
None
None
None
 1.10A 3eeyI-4u39A:
4.5		 3eeyI-4u39A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 GLY E 237
ASP E 233
GLY E 241
GLN E 145
ASN E 171
 None
 1.13A 3eeyI-4v1dE:
undetectable		 3eeyI-4v1dE:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18) 		5 GLY A 283
ILE A 250
GLY A 226
ASN A 221
LEU A 273
 None
None
None
MPD  A 402 ( 4.6A)
None
 1.18A 3eeyI-4w5zA:
undetectable		 3eeyI-4w5zA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcq TUBZ

(Clostridium
phage c-st) 		PF00091
(Tubulin) 		5 GLY A  15
ASN A  16
ASN A 174
ILE A  33
THR A 105
 None
GDP  A 401 (-3.9A)
GDP  A 401 (-2.8A)
None
None
 0.94A 3eeyI-4xcqA:
5.3		 3eeyI-4xcqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT
PUTATIVE
OXIDOREDUCTASE
IRON-SULFUR SUBUNIT

(Sulfurisphaera
tokodaii;
Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF00111
(Fer2)
PF01799
(Fer2_2) 		5 GLY C  53
ILE C 136
GLY C 135
ASN C  51
THR A 643
 FES  C 201 (-3.9A)
None
None
FAD  B 301 ( 4.2A)
None
 1.08A 3eeyI-4zohC:
undetectable		 3eeyI-4zohC:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ASP A 320
GLY A 162
HIS A 161
ASN A 192
THR A 265
 None
 1.00A 3eeyI-5a05A:
4.3		 3eeyI-5a05A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0l FIBRONECTIN-BINDING
PROTEIN

(Streptococcus
pyogenes) 		PF08341
(TED) 		5 GLY A 166
ILE A 178
GLY A 177
ASN A 172
LEU A 231
 None
 1.18A 3eeyI-5a0lA:
undetectable		 3eeyI-5a0lA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 THR A 767
ASN A 715
ASP A 605
ILE A 600
LEU A 774
 None
 1.18A 3eeyI-5a22A:
10.5		 3eeyI-5a22A:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6m DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Shewanella
halifaxensis) 		PF01791
(DeoC) 		5 THR A  25
ASN A  21
ASP A  23
ILE A  55
LEU A  32
 None
 1.06A 3eeyI-5c6mA:
undetectable		 3eeyI-5c6mA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 THR A 635
GLY A 668
ASN A 669
ASP A 637
GLY A 632
 None
 1.11A 3eeyI-5dkxA:
undetectable		 3eeyI-5dkxA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		6 THR A 100
ILE A 114
GLY A 115
HIS A 116
ASN A 135
LEU A 105
 None
 1.47A 3eeyI-5dldA:
3.8		 3eeyI-5dldA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 GLY A  42
ASN A  38
ASP A 126
GLN A 409
LEU A  22
 None
 1.12A 3eeyI-5h42A:
undetectable		 3eeyI-5h42A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 512
ASN A 508
GLY A 516
LEU A 497
THR A 519
 None
 1.11A 3eeyI-5i68A:
undetectable		 3eeyI-5i68A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASP A 125
ILE A 143
ASN A 124
LEU A 243
THR A 236
 None
 1.12A 3eeyI-5j0aA:
undetectable		 3eeyI-5j0aA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1b CELL WALL ASSEMBLY
REGULATOR SMI1

(Saccharomyces
cerevisiae) 		PF09346
(SMI1_KNR4) 		5 ASP A 144
ILE A 249
GLY A 250
LEU A 158
THR A 242
 None
 1.09A 3eeyI-5j1bA:
undetectable		 3eeyI-5j1bA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j60 THIOREDOXIN
REDUCTASE

(Gloeobacter
violaceus) 		PF07992
(Pyr_redox_2) 		5 ASP A 314
ILE A  10
GLY A  17
LEU A  29
THR A  77
 None
 1.17A 3eeyI-5j60A:
3.3		 3eeyI-5j60A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE

(Campylobacter
jejuni) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE) 		6 THR A 114
GLY A 117
ASN A 130
ILE A  95
GLY A  99
ASN A 779
 None
 1.42A 3eeyI-5jxlA:
undetectable		 3eeyI-5jxlA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]

(Ruminococcus
flavefaciens) 		no annotation 5 THR B 102
ASN B  72
ASP B  74
GLY B  99
ASN B  78
 None
None
CA  B 201 (-3.1A)
None
None
 1.16A 3eeyI-5m2sB:
undetectable		 3eeyI-5m2sB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A 121
ILE A  88
GLY A  87
ASN A 138
LEU A 119
 None
 1.08A 3eeyI-5n9xA:
3.0		 3eeyI-5n9xA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-8

(Caenorhabditis
elegans) 		PF10220
(Smg8_Smg9) 		5 GLY E  64
ASP E   2
ILE E  41
GLY E  38
LEU E  73
 None
 1.04A 3eeyI-5nkmE:
undetectable		 3eeyI-5nkmE:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A

(Methanothermococcus
thermolithotrophicus) 		PF00374
(NiFeSe_Hases) 		5 GLY F 376
ASN F 290
ASN F 402
GLY F 369
HIS F 380
 None
 1.13A 3eeyI-5odrF:
undetectable		 3eeyI-5odrF:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 169
ASP A 165
ILE A 123
GLY A 126
THR A 558
 None
 1.01A 3eeyI-5tf0A:
undetectable		 3eeyI-5tf0A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN

(Vibrio
vulnificus) 		no annotation 5 GLY A3895
ASP A4049
ILE A3898
GLY A3899
LEU A3890
 GLY  A3895 ( 0.0A)
ASP  A4049 ( 0.6A)
ILE  A3898 ( 0.7A)
GLY  A3899 ( 0.0A)
LEU  A3890 ( 0.6A)
 1.14A 3eeyI-5w6lA:
undetectable		 3eeyI-5w6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgz BETA-GLYCOSIDASE

(uncultured
microorganism) 		no annotation 5 ASP A 152
GLY A 223
ASN A 215
LEU A 158
THR A 220
 None
 1.08A 3eeyI-5xgzA:
undetectable		 3eeyI-5xgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE

(Saccharomyces
cerevisiae) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		5 THR A1085
GLY A1107
ASN A1128
GLY A1070
HIS A1068
 None
 1.14A 3eeyI-5xvmA:
3.0		 3eeyI-5xvmA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-) 		no annotation 5 ASN E 143
ILE E 126
GLY E 127
ASN E 145
THR E 148
 None
 1.17A 3eeyI-6gsaE:
undetectable		 3eeyI-6gsaE:
undetectable