SIMILAR PATTERNS OF AMINO ACIDS FOR 3EEY_F_SAMF300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE
PENICILLIN G AMIDASE

(Providencia
rettgeri;
Providencia
rettgeri) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		5 GLY B  39
ASN A  20
ASP A  21
ILE B  44
GLY B 158
 None
 1.14A 3eeyF-1cp9B:
undetectable		 3eeyF-1cp9B:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN

(Homo sapiens) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLY A 224
ILE A 307
GLY A 282
HIS A 286
LEU A 319
 FAD  A 599 (-3.6A)
None
None
FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
 1.08A 3eeyF-1efvA:
3.0		 3eeyF-1efvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyw PHOSPHOTRIESTERASE

(Brevundimonas
diminuta) 		PF02126
(PTE) 		5 ASP A 235
GLY A 209
GLN A 212
LEU A 287
THR A 200
 None
 1.15A 3eeyF-1eywA:
undetectable		 3eeyF-1eywA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyw PHOSPHOTRIESTERASE

(Brevundimonas
diminuta) 		PF02126
(PTE) 		6 ASP A 235
ILE A 228
GLY A 209
GLN A 212
LEU A 252
THR A 172
 None
 1.45A 3eeyF-1eywA:
undetectable		 3eeyF-1eywA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhl IGG1-KAPPA D11.15 FV
(LIGHT CHAIN)

(Mus musculus) 		PF07686
(V-set) 		5 ASP L  70
ILE L  87
ASN L  22
LEU L  73
THR L 102
 None
 1.12A 3eeyF-1jhlL:
undetectable		 3eeyF-1jhlL:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbu MURAMOYL-PENTAPEPTID
E CARBOXYPEPTIDASE

(Streptomyces
albus) 		PF01471
(PG_binding_1)
PF08291
(Peptidase_M15_3) 		5 GLY A  13
ILE A  64
GLY A  63
GLN A  54
THR A  69
 None
 1.11A 3eeyF-1lbuA:
undetectable		 3eeyF-1lbuA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.) 		PF07859
(Abhydrolase_3) 		5 GLY A 163
GLY A 291
LEU A 186
THR A 256
THR A 288
 None
 1.18A 3eeyF-1lzkA:
undetectable		 3eeyF-1lzkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Salmonella
enterica) 		PF00483
(NTP_transferase) 		5 ASP A 111
ILE A  52
ASN A 112
LEU A 107
THR A  43
 TTP  A 501 (-3.2A)
None
None
None
None
 1.13A 3eeyF-1mp3A:
undetectable		 3eeyF-1mp3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		5 GLY A 474
ASN A 478
GLY A 397
ASN A 673
THR A 401
 None
 1.16A 3eeyF-1n76A:
undetectable		 3eeyF-1n76A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A  66
ASP A 116
ILE A 207
GLY A 208
ASN A 158
 None
 0.87A 3eeyF-1r3nA:
undetectable		 3eeyF-1r3nA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk1 COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		5 GLY A  30
ILE A 120
GLY A  67
LEU A 240
THR A  63
 None
 1.11A 3eeyF-1tk1A:
undetectable		 3eeyF-1tk1A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkl COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		5 GLY A  30
ILE A 120
GLY A  67
LEU A 240
THR A  63
 None
 1.07A 3eeyF-1tklA:
undetectable		 3eeyF-1tklA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		5 GLY A 119
ASP A 144
ILE A 116
GLY A 115
LEU A  96
 None
 1.10A 3eeyF-1v4vA:
4.2		 3eeyF-1v4vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 THR A  79
GLY A  82
ASN A  87
GLY A  73
LEU A 172
 None
None
None
NAD  A 601 (-4.3A)
None
 1.17A 3eeyF-1vkoA:
undetectable		 3eeyF-1vkoA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE

(Thermotoga
maritima) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 GLY A 362
ILE A 400
GLY A 402
LEU A 392
THR A 357
 None
 0.86A 3eeyF-2b8nA:
4.0		 3eeyF-2b8nA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbg MYELOID CELL NUCLEAR
DIFFERENTIATION
ANTIGEN

(Homo sapiens) 		PF02758
(PYRIN) 		5 GLY A  20
ILE A  32
HIS A  28
ASN A  84
LEU A  89
 None
 1.17A 3eeyF-2dbgA:
undetectable		 3eeyF-2dbgA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		5 THR A 242
ASN A 277
ASP A 390
ILE A 213
GLY A 161
 BSC  A   2 (-3.7A)
None
None
None
None
 1.16A 3eeyF-2gwcA:
undetectable		 3eeyF-2gwcA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrb CARBONYL REDUCTASE
[NADPH] 3

(Homo sapiens) 		PF00106
(adh_short) 		5 THR A  11
ASN A  14
ILE A  70
ASN A  90
THR A 118
 None
NAP  A1001 (-3.1A)
None
NAP  A1001 (-3.3A)
None
 1.17A 3eeyF-2hrbA:
9.1		 3eeyF-2hrbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kc2 TALIN-1

(Mus musculus) 		PF09379
(FERM_N) 		5 THR A 114
ASP A 110
ILE A 119
GLY A 120
LEU A  88
 None
 1.08A 3eeyF-2kc2A:
undetectable		 3eeyF-2kc2A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oda HYPOTHETICAL PROTEIN
PSPTO_2114

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 GLY A  12
GLY A  21
GLN A  23
LEU A 117
THR A  26
 None
 1.17A 3eeyF-2odaA:
3.4		 3eeyF-2odaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 THR A 111
GLY A 109
GLY A 126
HIS A  53
LEU A 137
 None
None
None
FE  A 253 (-3.3A)
None
 1.19A 3eeyF-2qedA:
undetectable		 3eeyF-2qedA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 GLY A 225
ASP A 289
ILE A 212
GLY A 213
THR A 218
 None
 0.98A 3eeyF-2x3kA:
undetectable		 3eeyF-2x3kA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 GLY A 316
ASN A  14
ILE A 270
GLY A 131
GLN A 134
 None
 1.14A 3eeyF-2xf8A:
3.6		 3eeyF-2xf8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 THR A 671
GLY A 669
ILE A 702
HIS A 673
THR A 657
 None
 1.12A 3eeyF-2xt6A:
undetectable		 3eeyF-2xt6A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		5 THR A 220
GLY A 222
ASP A 193
GLY A 273
ASN A 192
 AMP  A 502 (-3.4A)
AMP  A 502 (-3.5A)
None
None
None
 0.88A 3eeyF-3b1rA:
3.3		 3eeyF-3b1rA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt6 INFLUENZA B
HEMAGGLUTININ (HA)

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		5 THR B  25
GLY B  23
ILE B 152
LEU B 118
THR B 140
 None
 1.14A 3eeyF-3bt6B:
undetectable		 3eeyF-3bt6B:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdx SUCCINYLGLUTAMATEDES
UCCINYLASE/ASPARTOAC
YLASE

(Rhodobacter
sphaeroides) 		PF04952
(AstE_AspA) 		5 THR A 157
GLY A 215
ILE A 227
GLN A 250
THR A 257
 None
 1.14A 3eeyF-3cdxA:
undetectable		 3eeyF-3cdxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dci ARYLESTERASE

(Agrobacterium
fabrum) 		PF13472
(Lipase_GDSL_2) 		5 GLY A  50
ASP A  91
LEU A  48
THR A  12
THR A 193
 ACY  A 220 (-3.7A)
None
None
None
None
 1.01A 3eeyF-3dciA:
4.2		 3eeyF-3dciA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 THR A 424
ASP A 393
ILE A 419
GLY A 420
LEU A 431
 None
 1.13A 3eeyF-3dmyA:
undetectable		 3eeyF-3dmyA:
15.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		12 THR A  28
GLY A  30
ASN A  33
ASP A  34
ILE A  53
GLY A  80
HIS A  81
GLN A  82
ASN A  98
LEU A 102
THR A 111
THR A 115
 SAM  A 300 (-4.1A)
SAM  A 300 (-3.4A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.9A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.5A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 3.8A)
SAM  A 300 (-4.4A)
SAM  A 300 ( 4.3A)
 0.36A 3eeyF-3eeyA:
36.5		 3eeyF-3eeyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h41 NLP/P60 FAMILY
PROTEIN

(Bacillus cereus) 		PF00877
(NLPC_P60) 		5 ILE A 227
GLY A 230
GLN A  85
LEU A  74
THR A  39
 None
 0.75A 3eeyF-3h41A:
undetectable		 3eeyF-3h41A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i12 D-ALANINE-D-ALANINE
LIGASE A

(Salmonella
enterica) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 GLY A  11
ASP A  44
ILE A   8
GLY A   7
LEU A  21
 None
 1.03A 3eeyF-3i12A:
undetectable		 3eeyF-3i12A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 21

(Homo sapiens) 		PF00443
(UCH) 		5 GLY A 213
ASN A 224
HIS A 530
LEU A 269
THR A 527
 None
 1.13A 3eeyF-3i3tA:
undetectable		 3eeyF-3i3tA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 THR A 159
ILE A 119
GLY A 118
ASN A 160
LEU A 131
 None
None
None
PEG  A 425 (-3.3A)
PEG  A 425 (-4.5A)
 1.17A 3eeyF-3k92A:
3.4		 3eeyF-3k92A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE

(Streptomyces
coelicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 122
ASP A 124
ILE A  58
GLY A 402
ASN A  83
 None
 1.13A 3eeyF-3krtA:
5.9		 3eeyF-3krtA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 GLY A 757
ASN A 781
ASP A 458
ILE A 420
LEU A 760
 None
 1.19A 3eeyF-3la4A:
undetectable		 3eeyF-3la4A:
13.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lby PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1697C

(Streptococcus
mutans) 		PF06962
(rRNA_methylase) 		6 THR A  27
ASN A  30
GLY A  75
HIS A  76
GLN A  77
THR A 106
 SAH  A4630 (-4.2A)
None
SAH  A4630 (-3.3A)
SAH  A4630 (-3.1A)
SAH  A4630 (-3.8A)
SAH  A4630 (-4.5A)
 1.12A 3eeyF-3lbyA:
30.3		 3eeyF-3lbyA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lby PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1697C

(Streptococcus
mutans) 		PF06962
(rRNA_methylase) 		10 THR A  27
GLY A  29
ASN A  32
ASP A  33
GLY A  75
HIS A  76
GLN A  77
ASN A  93
THR A 106
THR A 110
 SAH  A4630 (-4.2A)
SAH  A4630 (-3.6A)
None
None
SAH  A4630 (-3.3A)
SAH  A4630 (-3.1A)
SAH  A4630 (-3.8A)
None
SAH  A4630 (-4.5A)
SAH  A4630 ( 4.1A)
 0.42A 3eeyF-3lbyA:
30.3		 3eeyF-3lbyA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lby PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1697C

(Streptococcus
mutans) 		PF06962
(rRNA_methylase) 		10 THR A  27
GLY A  29
ASP A  33
GLY A  75
HIS A  76
GLN A  77
ASN A  93
LEU A  97
THR A 106
THR A 110
 SAH  A4630 (-4.2A)
SAH  A4630 (-3.6A)
None
SAH  A4630 (-3.3A)
SAH  A4630 (-3.1A)
SAH  A4630 (-3.8A)
None
SAH  A4630 (-3.9A)
SAH  A4630 (-4.5A)
SAH  A4630 ( 4.1A)
 0.52A 3eeyF-3lbyA:
30.3		 3eeyF-3lbyA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		6 THR A  27
ASN A  30
GLY A  75
HIS A  76
ASN A  93
THR A 110
 None
 1.30A 3eeyF-3mtiA:
27.1		 3eeyF-3mtiA:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		8 THR A  27
GLY A  29
ASN A  32
ASP A  33
GLY A  75
HIS A  76
ASN A  93
THR A 110
 None
 0.54A 3eeyF-3mtiA:
27.1		 3eeyF-3mtiA:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2x UNCHARACTERIZED
PROTEIN YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		5 THR A  15
GLY A 217
ASP A  49
GLY A 172
LEU A 211
 None
 1.14A 3eeyF-3n2xA:
undetectable		 3eeyF-3n2xA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
ADRENODOXIN,
MITOCHONDRIAL

(Homo sapiens;
Homo sapiens) 		PF00067
(p450)
PF00111
(Fer2) 		5 ASP C  72
ILE A 467
GLY A 464
LEU A 168
THR A 331
 None
HEM  A 601 ( 4.9A)
HEM  A 601 (-3.5A)
None
HEM  A 601 ( 4.7A)
 1.14A 3eeyF-3na0C:
undetectable		 3eeyF-3na0C:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		5 THR A 276
GLY A 169
ASN A 262
ILE A 152
GLY A 148
 None
 0.94A 3eeyF-3oqbA:
4.4		 3eeyF-3oqbA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 ASP B 201
ILE B 224
GLY B 386
LEU B 332
THR B 377
 None
 1.15A 3eeyF-3pcoB:
undetectable		 3eeyF-3pcoB:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 GLY A 744
ASP A 256
ILE A 741
GLY A 740
HIS A 260
 None
 1.13A 3eeyF-3qr1A:
2.8		 3eeyF-3qr1A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Mycobacteroides
abscessus) 		PF00106
(adh_short) 		5 THR A  59
GLY A  15
ASP A  55
ILE A  34
THR A  66
 None
 1.08A 3eeyF-3s55A:
3.5		 3eeyF-3s55A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 GLY A 507
ASN A 509
GLY A 503
LEU A 474
THR A 500
 None
None
AMP  A 747 ( 4.0A)
None
None
 1.06A 3eeyF-3ttfA:
undetectable		 3eeyF-3ttfA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubr CYTOCHROME C-552

(Shewanella
oneidensis) 		PF02335
(Cytochrom_C552) 		5 THR A 154
GLY A 156
ASP A 126
GLY A  90
ASN A 153
 None
HEC  A 472 (-4.0A)
None
HEC  A 473 ( 4.4A)
None
 1.08A 3eeyF-3ubrA:
undetectable		 3eeyF-3ubrA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxy PUTATIVE
UNCHARACTERIZED
PROTEIN CSYB

(Aspergillus
oryzae) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 312
ILE A 345
GLY A 154
HIS A 377
LEU A 212
 COA  A 401 (-3.8A)
None
None
None
None
 1.11A 3eeyF-3wxyA:
undetectable		 3eeyF-3wxyA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A

(Saccharomyces
cerevisiae) 		PF16787
(NDC10_II) 		5 ASN A 143
ILE A 126
GLY A 127
ASN A 145
THR A 148
 None
 1.15A 3eeyF-4acoA:
undetectable		 3eeyF-4acoA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Pseudomonas
aeruginosa) 		PF00483
(NTP_transferase) 		5 ASP A 110
ILE A  51
ASN A 111
LEU A 106
THR A  42
 None
None
None
None
N5Y  A1294 (-4.5A)
 1.16A 3eeyF-4asyA:
undetectable		 3eeyF-4asyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw5 DFNA

(Bacillus
velezensis) 		PF03060
(NMO) 		5 THR A 356
GLY A 358
ILE A 361
GLY A 365
ASN A 384
 None
None
None
None
FMN  A1753 (-2.8A)
 1.03A 3eeyF-4cw5A:
undetectable		 3eeyF-4cw5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1e ALPHA-ACTININ-2

(Homo sapiens) 		PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen) 		5 GLY A 185
ASN A 170
ILE A 245
GLN A  39
ASN A 211
 None
 1.13A 3eeyF-4d1eA:
undetectable		 3eeyF-4d1eA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eae LMO1068 PROTEIN

(Listeria
monocytogenes) 		PF16781
(DUF5068) 		5 GLY A 222
ASN A 229
ASP A 226
GLY A 217
HIS A 219
 None
 1.18A 3eeyF-4eaeA:
undetectable		 3eeyF-4eaeA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Salmonella
enterica) 		PF12710
(HAD) 		5 THR A 212
ASN A 209
ASP A 208
ILE A 138
GLY A 139
 None
 1.17A 3eeyF-4ezeA:
2.2		 3eeyF-4ezeA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqa NAD BINDING
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A 365
ASN A 361
GLY A 192
HIS A 194
LEU A 107
 None
 0.96A 3eeyF-4gqaA:
4.6		 3eeyF-4gqaA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		5 THR A  54
GLY A  56
ASN A  58
ILE A  49
GLY A  50
 None
NO3  A 604 ( 4.2A)
NO3  A 604 (-4.3A)
None
None
 1.08A 3eeyF-4i8vA:
undetectable		 3eeyF-4i8vA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inj LMO1638 PROTEIN

(Listeria
monocytogenes) 		PF02016
(Peptidase_S66) 		5 ILE A 113
GLY A 109
LEU A 210
THR A 118
THR A 128
 None
 1.17A 3eeyF-4injA:
undetectable		 3eeyF-4injA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		5 ASP A 157
ILE A  23
GLY A  27
ASN A 155
LEU A  14
 None
 1.18A 3eeyF-4jhiA:
undetectable		 3eeyF-4jhiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF05431
(Toxin_10) 		6 THR A 335
GLY A 234
ASN A 338
ASP A 337
ILE A 237
GLN A 332
 None
 1.34A 3eeyF-4jp0A:
undetectable		 3eeyF-4jp0A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		6 GLY A 253
ASP A 377
ILE A 283
GLY A 281
LEU A 407
THR A 437
 None
None
NK  A 501 (-4.4A)
None
None
None
 1.36A 3eeyF-4jz6A:
undetectable		 3eeyF-4jz6A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt7 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Anaerococcus
prevotii) 		PF01128
(IspD) 		6 THR A  89
GLY A  92
ILE A  11
LEU A  96
THR A 105
THR A 164
 None
 1.45A 3eeyF-4kt7A:
undetectable		 3eeyF-4kt7A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		5 GLY A  10
ASN A  71
GLY A 444
LEU A 425
THR A  13
 None
 1.11A 3eeyF-4mdpA:
undetectable		 3eeyF-4mdpA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp3 PUTATIVE ORNITHINE
CYCLODEAMINASE

(Staphylococcus
aureus) 		PF02423
(OCD_Mu_crystall) 		5 GLY A 330
ILE A 320
GLY A  17
ASN A 328
LEU A   6
 None
 1.11A 3eeyF-4mp3A:
4.3		 3eeyF-4mp3A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		5 THR A  15
GLY A 217
ASP A  49
GLY A 172
LEU A 211
 None
None
EDO  A 403 (-3.8A)
None
None
 1.14A 3eeyF-4oe7A:
2.0		 3eeyF-4oe7A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht GENERAL SECRETORY
PATHWAY PROTEIN E

(Vibrio
vulnificus) 		PF00437
(T2SSE) 		5 ASP A 154
ILE A 440
GLY A 478
THR A 438
THR A 487
 None
 1.11A 3eeyF-4phtA:
4.1		 3eeyF-4phtA:
16.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis) 		PF06962
(rRNA_methylase) 		8 THR A  28
GLY A  30
ASP A  34
ILE A  53
HIS A  80
ASN A 101
LEU A 105
THR A 114
 SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
 0.51A 3eeyF-4pooA:
29.6		 3eeyF-4pooA:
44.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 THR A 223
GLY A 225
ASP A 196
GLY A 280
ASN A 195
 None
 1.05A 3eeyF-4pvvA:
4.0		 3eeyF-4pvvA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 GLY E 237
ASP E 233
GLY E 241
GLN E 145
ASN E 171
 None
 1.11A 3eeyF-4v1dE:
undetectable		 3eeyF-4v1dE:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 GLY A 442
ILE A 520
GLY A 522
HIS A 521
THR A 511
 EDO  A 706 ( 4.5A)
None
None
None
None
 1.13A 3eeyF-4wd1A:
undetectable		 3eeyF-4wd1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk4 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP) 		6 ASN A 367
ASP A 293
ASN A 295
LEU A 394
THR A 339
THR A 337
 None
CA  A 502 (-3.3A)
CA  A 502 (-3.0A)
None
None
MAN  A 514 ( 4.9A)
 1.48A 3eeyF-4wk4A:
undetectable		 3eeyF-4wk4A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT
PUTATIVE
OXIDOREDUCTASE
IRON-SULFUR SUBUNIT

(Sulfurisphaera
tokodaii;
Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF00111
(Fer2)
PF01799
(Fer2_2) 		5 GLY C  53
ILE C 136
GLY C 135
ASN C  51
THR A 643
 FES  C 201 (-3.9A)
None
None
FAD  B 301 ( 4.2A)
None
 1.05A 3eeyF-4zohC:
undetectable		 3eeyF-4zohC:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ASP A 320
GLY A 162
HIS A 161
ASN A 192
THR A 265
 None
 0.98A 3eeyF-5a05A:
4.6		 3eeyF-5a05A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0l FIBRONECTIN-BINDING
PROTEIN

(Streptococcus
pyogenes) 		PF08341
(TED) 		5 GLY A 166
ILE A 178
GLY A 177
ASN A 172
LEU A 231
 None
 1.06A 3eeyF-5a0lA:
undetectable		 3eeyF-5a0lA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 THR A 767
ASN A 715
ASP A 605
ILE A 600
LEU A 774
 None
 1.17A 3eeyF-5a22A:
5.9		 3eeyF-5a22A:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo sapiens) 		PF12851
(Tet_JBP) 		5 GLY A1282
GLY A1256
ASN A1890
THR A1249
THR A1251
 None
 1.15A 3eeyF-5deuA:
undetectable		 3eeyF-5deuA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eut PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA,ENDOLYSIN,PH
OSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens;
Escherichia
virus T4) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		5 ASN A 437
ASP A 436
ILE A 427
GLY A 425
LEU A 385
 None
 1.07A 3eeyF-5eutA:
undetectable		 3eeyF-5eutA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium) 		PF00497
(SBP_bac_3) 		5 GLY A 206
GLY A 132
LEU A  53
THR A 111
THR A 113
 None
None
None
GGL  A 301 (-3.9A)
GGL  A 301 (-4.0A)
 1.15A 3eeyF-5eyfA:
undetectable		 3eeyF-5eyfA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gja 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
OXIDASE 2

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 GLY A  35
ILE A 187
GLY A 185
LEU A 200
THR A 181
 None
6PC  A 402 ( 4.7A)
None
None
None
 1.08A 3eeyF-5gjaA:
undetectable		 3eeyF-5gjaA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5haf DEUBIQUITINASE SSEL

(Salmonella
enterica) 		no annotation 5 THR A 220
GLY A 186
HIS A 223
GLN A 278
THR A 243
 None
 1.12A 3eeyF-5hafA:
undetectable		 3eeyF-5hafA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j60 THIOREDOXIN
REDUCTASE

(Gloeobacter
violaceus) 		PF07992
(Pyr_redox_2) 		5 ASP A 314
ILE A  10
GLY A  17
LEU A  29
THR A  77
 None
 1.01A 3eeyF-5j60A:
undetectable		 3eeyF-5j60A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j62 PUTATIVE REDUCTASE

(Clostridioides
difficile) 		PF00881
(Nitroreductase) 		5 THR A  94
GLY A 194
ILE A 191
GLY A 190
LEU A 127
 None
 1.13A 3eeyF-5j62A:
2.1		 3eeyF-5j62A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE

(Campylobacter
jejuni) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE) 		6 THR A 114
GLY A 117
ASN A 130
ILE A  95
GLY A  99
ASN A 779
 None
 1.44A 3eeyF-5jxlA:
undetectable		 3eeyF-5jxlA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 GLY A 412
ASP A 436
ILE A 335
GLY A 444
THR A 310
 ATP  A 703 ( 3.4A)
6R9  A 704 ( 3.5A)
None
None
None
 1.18A 3eeyF-5k8fA:
undetectable		 3eeyF-5k8fA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		5 THR A 892
GLY A 894
ASN A 877
ASP A 878
ILE A 912
 CA  A9014 (-4.7A)
CA  A9014 ( 4.6A)
None
CA  A9014 (-3.4A)
None
 1.18A 3eeyF-5n8pA:
undetectable		 3eeyF-5n8pA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		5 THR A 892
GLY A 894
ASN A 877
ASP A 878
ILE A 912
 CA  A9014 (-4.7A)
CA  A9014 ( 4.6A)
None
CA  A9014 (-3.4A)
None
 1.18A 3eeyF-5n97A:
undetectable		 3eeyF-5n97A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-8

(Caenorhabditis
elegans) 		PF10220
(Smg8_Smg9) 		5 GLY E  64
ASP E   2
ILE E  41
GLY E  38
LEU E  73
 None
 1.02A 3eeyF-5nkmE:
undetectable		 3eeyF-5nkmE:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3m PROTOCATECHUATE
DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF01977
(UbiD) 		5 THR A 168
ASN A 232
ILE A 208
GLY A 152
HIS A 170
 None
 1.19A 3eeyF-5o3mA:
undetectable		 3eeyF-5o3mA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 169
ASP A 165
ILE A 123
GLY A 126
THR A 558
 None
 1.03A 3eeyF-5tf0A:
2.5		 3eeyF-5tf0A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv7 PUTATIVE
PEPTIDOGLYCAN-BINDIN
G/HYDROLYSING
PROTEIN

(Clostridioides
difficile) 		PF01471
(PG_binding_1) 		5 GLY A 134
ILE A 182
GLY A 181
GLN A 172
THR A 187
 None
HGA  A 301 (-3.9A)
None
HGA  A 301 ( 4.6A)
HGA  A 301 (-3.6A)
 1.19A 3eeyF-5tv7A:
undetectable		 3eeyF-5tv7A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubu PUTATIVE
ACETAMIDASE/FORMAMID
ASE

(Yersinia
enterocolitica) 		PF03069
(FmdA_AmdA) 		5 GLY A 188
ASP A 185
GLY A 319
ASN A 186
LEU A 204
 None
 1.01A 3eeyF-5ubuA:
undetectable		 3eeyF-5ubuA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2i GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica) 		PF01112
(Asparaginase_2) 		5 GLY A  52
ASP A  44
GLY A 154
ASN A  87
LEU A  65
 None
 0.89A 3eeyF-5v2iA:
undetectable		 3eeyF-5v2iA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wat HOMOSERINE KINASE

(Corynebacterium
glutamicum) 		no annotation 5 THR A  28
GLY A  30
ASN A 140
ILE A 217
LEU A  22
 None
None
PO4  A 402 (-3.7A)
None
None
 1.14A 3eeyF-5watA:
undetectable		 3eeyF-5watA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 ILE A 563
GLY A 553
ASN A 814
LEU A 517
THR A 531
 None
 1.01A 3eeyF-5wugA:
undetectable		 3eeyF-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xs7 HEAVY CHAIN OF FAB
1D5

(Mus musculus) 		PF07686
(V-set) 		5 THR H 123
GLY H   9
LEU H  19
THR H  99
THR H  45
 None
 1.02A 3eeyF-5xs7H:
undetectable		 3eeyF-5xs7H:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE

(Saccharomyces
cerevisiae) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		5 THR A1085
GLY A1107
ASN A1128
GLY A1070
HIS A1068
 None
 1.12A 3eeyF-5xvmA:
undetectable		 3eeyF-5xvmA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		no annotation 5 ASP A 108
ILE A  49
ASN A 109
LEU A 104
THR A  40
 MG  A 302 ( 2.5A)
None
DAU  A 301 (-3.2A)
None
None
 0.92A 3eeyF-6b5eA:
undetectable		 3eeyF-6b5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE

(Acetobacterium
woodii) 		no annotation 5 GLY A 285
ILE A 368
GLY A 343
HIS A 347
LEU A 380
 FAD  A 401 (-3.7A)
None
FAD  A 401 ( 4.9A)
FAD  A 401 (-4.2A)
FAD  A 401 (-4.2A)
 1.17A 3eeyF-6fahA:
undetectable		 3eeyF-6fahA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-) 		no annotation 5 ASN E 143
ILE E 126
GLY E 127
ASN E 145
THR E 148
 None
 1.15A 3eeyF-6gsaE:
undetectable		 3eeyF-6gsaE:
undetectable