SIMILAR PATTERNS OF AMINO ACIDS FOR 3EEY_E_SAME300_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1) 		PF00082
(Peptidase_S8) 		5 GLY A  14
ASN A  17
ILE A  90
GLY A  78
HIS A  75
 None
 1.13A 3eeyE-1dbiA:
undetectable		 3eeyE-1dbiA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLY A 202
ILE A 285
GLY A 260
HIS A 264
LEU A 297
 FAD  A 399 (-3.1A)
None
None
FAD  A 399 (-3.9A)
FAD  A 399 (-3.6A)
 1.17A 3eeyE-1efpA:
2.8		 3eeyE-1efpA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN

(Homo sapiens) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLY A 224
ILE A 307
GLY A 282
HIS A 286
LEU A 319
 FAD  A 599 (-3.6A)
None
None
FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
 1.11A 3eeyE-1efvA:
2.9		 3eeyE-1efvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyw PHOSPHOTRIESTERASE

(Brevundimonas
diminuta) 		PF02126
(PTE) 		5 ASP A 235
GLY A 209
GLN A 212
LEU A 287
THR A 200
 None
 1.15A 3eeyE-1eywA:
undetectable		 3eeyE-1eywA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyw PHOSPHOTRIESTERASE

(Brevundimonas
diminuta) 		PF02126
(PTE) 		6 ASP A 235
ILE A 228
GLY A 209
GLN A 212
LEU A 252
THR A 172
 None
 1.45A 3eeyE-1eywA:
undetectable		 3eeyE-1eywA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		5 THR A 170
GLY A 172
ILE A 145
GLY A 144
LEU A 166
 None
 1.16A 3eeyE-1i8dA:
undetectable		 3eeyE-1i8dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 GLY A  95
ASN A  96
ILE A  62
GLY A 118
LEU A  94
 None
 1.06A 3eeyE-1jftA:
undetectable		 3eeyE-1jftA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbu MURAMOYL-PENTAPEPTID
E CARBOXYPEPTIDASE

(Streptomyces
albus) 		PF01471
(PG_binding_1)
PF08291
(Peptidase_M15_3) 		5 GLY A  13
ILE A  64
GLY A  63
GLN A  54
THR A  69
 None
 1.10A 3eeyE-1lbuA:
undetectable		 3eeyE-1lbuA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Salmonella
enterica) 		PF00483
(NTP_transferase) 		5 ASP A 111
ILE A  52
ASN A 112
LEU A 107
THR A  43
 TTP  A 501 (-3.2A)
None
None
None
None
 1.12A 3eeyE-1mp3A:
undetectable		 3eeyE-1mp3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		5 THR A 468
GLY A 437
ASN A 518
ILE A 459
ASN A 467
 None
CA  A 914 ( 4.0A)
None
None
None
 0.57A 3eeyE-1q5aA:
undetectable		 3eeyE-1q5aA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A  66
ASP A 116
ILE A 207
GLY A 208
ASN A 158
 None
 0.87A 3eeyE-1r3nA:
undetectable		 3eeyE-1r3nA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 GLY A 271
ASN A 270
ILE A 171
GLY A 167
THR A 280
 175  A 211 ( 4.6A)
175  A 211 ( 4.0A)
None
None
None
 1.15A 3eeyE-1t6pA:
undetectable		 3eeyE-1t6pA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk1 COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		5 GLY A  30
ILE A 120
GLY A  67
LEU A 240
THR A  63
 None
 1.13A 3eeyE-1tk1A:
undetectable		 3eeyE-1tk1A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkl COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		5 GLY A  30
ILE A 120
GLY A  67
LEU A 240
THR A  63
 None
 1.08A 3eeyE-1tklA:
undetectable		 3eeyE-1tklA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		5 GLY A 119
ASP A 144
ILE A 116
GLY A 115
LEU A  96
 None
 1.00A 3eeyE-1v4vA:
4.3		 3eeyE-1v4vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 GLY A 242
ILE A 230
ASN A 150
LEU A 170
THR A 190
 None
 1.19A 3eeyE-2akzA:
undetectable		 3eeyE-2akzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE

(Thermotoga
maritima) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 GLY A 362
ILE A 400
GLY A 402
LEU A 392
THR A 357
 None
 0.96A 3eeyE-2b8nA:
3.9		 3eeyE-2b8nA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE

(Pyrococcus
horikoshii) 		PF00390
(malic)
PF03949
(Malic_M) 		5 GLY A  63
ASN A  64
GLY A  54
LEU A 340
THR A 400
 None
None
MES  A2759 ( 3.7A)
None
None
 1.19A 3eeyE-2dvmA:
5.2		 3eeyE-2dvmA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 GLY A 214
ASN A 213
GLY A  81
GLN A  43
ASN A 220
 None
 0.92A 3eeyE-2eb5A:
undetectable		 3eeyE-2eb5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLY A 196
ASN A  27
ILE A 211
GLY A 145
HIS A 119
 None
None
None
None
ZN  A 561 ( 3.1A)
 0.86A 3eeyE-2it4A:
undetectable		 3eeyE-2it4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kc2 TALIN-1

(Mus musculus) 		PF09379
(FERM_N) 		5 THR A 114
ASP A 110
ILE A 119
GLY A 120
LEU A  88
 None
 1.05A 3eeyE-2kc2A:
undetectable		 3eeyE-2kc2A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oda HYPOTHETICAL PROTEIN
PSPTO_2114

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 GLY A  12
GLY A  21
GLN A  23
LEU A 117
THR A  26
 None
 1.17A 3eeyE-2odaA:
undetectable		 3eeyE-2odaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q42 PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 2

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 THR A 113
GLY A 111
GLY A 130
HIS A  54
LEU A 141
 None
None
None
ZN  A 700 (-3.2A)
None
 1.15A 3eeyE-2q42A:
undetectable		 3eeyE-2q42A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 THR A 111
GLY A 109
GLY A 126
HIS A  53
LEU A 137
 None
None
None
FE  A 253 (-3.3A)
None
 1.12A 3eeyE-2qedA:
undetectable		 3eeyE-2qedA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqs AGGLUTININ RECEPTOR

(Streptococcus
gordonii) 		PF16364
(Antigen_C) 		5 ASN A1319
ILE A1386
GLY A1313
ASN A1284
THR A1413
 None
 1.02A 3eeyE-2wqsA:
undetectable		 3eeyE-2wqsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 GLY A 225
ASP A 289
ILE A 212
GLY A 213
THR A 218
 None
 0.99A 3eeyE-2x3kA:
undetectable		 3eeyE-2x3kA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		6 THR A 435
ASP A 437
GLY A 380
ASN A 436
LEU A 328
THR A  92
 None
 1.17A 3eeyE-2xijA:
undetectable		 3eeyE-2xijA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 THR A 671
GLY A 669
ILE A 702
HIS A 673
THR A 657
 None
 1.14A 3eeyE-2xt6A:
undetectable		 3eeyE-2xt6A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		5 THR A 220
GLY A 222
ASP A 193
GLY A 273
ASN A 192
 AMP  A 502 (-3.4A)
AMP  A 502 (-3.5A)
None
None
None
 0.91A 3eeyE-3b1rA:
3.2		 3eeyE-3b1rA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt6 INFLUENZA B
HEMAGGLUTININ (HA)

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		5 THR B  25
GLY B  23
ILE B 152
LEU B 118
THR B 140
 None
 1.05A 3eeyE-3bt6B:
undetectable		 3eeyE-3bt6B:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdx SUCCINYLGLUTAMATEDES
UCCINYLASE/ASPARTOAC
YLASE

(Rhodobacter
sphaeroides) 		PF04952
(AstE_AspA) 		5 THR A 157
GLY A 215
ILE A 227
GLN A 250
THR A 257
 None
 1.12A 3eeyE-3cdxA:
undetectable		 3eeyE-3cdxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dci ARYLESTERASE

(Agrobacterium
fabrum) 		PF13472
(Lipase_GDSL_2) 		5 GLY A  50
ASP A  91
LEU A  48
THR A  12
THR A 193
 ACY  A 220 (-3.7A)
None
None
None
None
 0.99A 3eeyE-3dciA:
4.1		 3eeyE-3dciA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 THR A 424
ASP A 393
ILE A 419
GLY A 420
LEU A 431
 None
 1.10A 3eeyE-3dmyA:
3.7		 3eeyE-3dmyA:
15.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		5 ASN A  60
ILE A  53
GLY A  80
GLN A  82
THR A 115
 None
SAM  A 300 (-4.0A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
SAM  A 300 ( 4.3A)
 0.89A 3eeyE-3eeyA:
36.8		 3eeyE-3eeyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		12 THR A  28
GLY A  30
ASN A  31
ASP A  34
ILE A  53
GLY A  80
HIS A  81
GLN A  82
ASN A  98
LEU A 102
THR A 111
THR A 115
 SAM  A 300 (-4.1A)
SAM  A 300 (-3.4A)
SAM  A 300 (-4.7A)
SAM  A 300 (-3.9A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.5A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 3.8A)
SAM  A 300 (-4.4A)
SAM  A 300 ( 4.3A)
 0.20A 3eeyE-3eeyA:
36.8		 3eeyE-3eeyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h41 NLP/P60 FAMILY
PROTEIN

(Bacillus cereus) 		PF00877
(NLPC_P60) 		5 ILE A 227
GLY A 230
GLN A  85
LEU A  74
THR A  39
 None
 0.67A 3eeyE-3h41A:
undetectable		 3eeyE-3h41A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i12 D-ALANINE-D-ALANINE
LIGASE A

(Salmonella
enterica) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 GLY A  11
ASP A  44
ILE A   8
GLY A   7
LEU A  21
 None
 1.19A 3eeyE-3i12A:
undetectable		 3eeyE-3i12A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in1 UNCHARACTERIZED
SUGAR KINASE YDJH

(Escherichia
coli) 		PF00294
(PfkB) 		5 GLY A  10
ASP A  43
ILE A 156
ASN A 144
LEU A 121
 None
 1.11A 3eeyE-3in1A:
4.5		 3eeyE-3in1A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE

(Streptomyces
coelicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 122
ASP A 124
ILE A  58
GLY A 402
ASN A  83
 None
 1.12A 3eeyE-3krtA:
5.0		 3eeyE-3krtA:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lby PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1697C

(Streptococcus
mutans) 		PF06962
(rRNA_methylase) 		11 THR A  27
GLY A  29
ASN A  30
ASP A  33
GLY A  75
HIS A  76
GLN A  77
ASN A  93
LEU A  97
THR A 106
THR A 110
 SAH  A4630 (-4.2A)
SAH  A4630 (-3.6A)
None
None
SAH  A4630 (-3.3A)
SAH  A4630 (-3.1A)
SAH  A4630 (-3.8A)
None
SAH  A4630 (-3.9A)
SAH  A4630 (-4.5A)
SAH  A4630 ( 4.1A)
 0.49A 3eeyE-3lbyA:
30.3		 3eeyE-3lbyA:
44.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcz O-METHYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 THR A 189
ILE A 205
GLY A 185
LEU A 224
THR A 211
 None
 1.14A 3eeyE-3mczA:
13.3		 3eeyE-3mczA:
18.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		6 THR A  27
GLY A  29
ASN A  30
GLY A  75
HIS A  76
THR A 110
 None
 0.88A 3eeyE-3mtiA:
27.1		 3eeyE-3mtiA:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		7 THR A  27
GLY A  29
ASP A  33
GLY A  75
HIS A  76
ASN A  93
THR A 110
 None
 0.50A 3eeyE-3mtiA:
27.1		 3eeyE-3mtiA:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
ADRENODOXIN,
MITOCHONDRIAL

(Homo sapiens;
Homo sapiens) 		PF00067
(p450)
PF00111
(Fer2) 		5 ASP C  72
ILE A 467
GLY A 464
LEU A 168
THR A 331
 None
HEM  A 601 ( 4.9A)
HEM  A 601 (-3.5A)
None
HEM  A 601 ( 4.7A)
 1.18A 3eeyE-3na0C:
undetectable		 3eeyE-3na0C:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 5 THR A 216
GLY A 198
ASN A 178
ASP A 196
GLY A 257
 None
CA  A 409 (-4.2A)
None
None
CA  A 412 (-4.3A)
 1.17A 3eeyE-3p4gA:
undetectable		 3eeyE-3p4gA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 ASN A 695
ILE A 519
GLY A 518
ASN A 688
THR A 676
 None
 1.16A 3eeyE-3psfA:
undetectable		 3eeyE-3psfA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 GLY A 744
ASP A 256
ILE A 741
GLY A 740
HIS A 260
 None
 1.14A 3eeyE-3qr1A:
undetectable		 3eeyE-3qr1A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5c LINA

(uncultured
organism) 		no annotation 5 GLY B 131
ASN B 130
ILE B 109
HIS B  73
THR B  71
 None
 1.12A 3eeyE-3s5cB:
undetectable		 3eeyE-3s5cB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 141
ASP A 137
ILE A  95
GLY A  98
THR A 521
 None
 1.02A 3eeyE-3u4aA:
undetectable		 3eeyE-3u4aA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxy PUTATIVE
UNCHARACTERIZED
PROTEIN CSYB

(Aspergillus
oryzae) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 312
ILE A 345
GLY A 154
HIS A 377
LEU A 212
 COA  A 401 (-3.8A)
None
None
None
None
 1.18A 3eeyE-3wxyA:
undetectable		 3eeyE-3wxyA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 THR A 671
GLY A 669
ILE A 702
HIS A 673
THR A 657
 None
 1.14A 3eeyE-3zhrA:
undetectable		 3eeyE-3zhrA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Pseudomonas
aeruginosa) 		PF00483
(NTP_transferase) 		5 ASP A 110
ILE A  51
ASN A 111
LEU A 106
THR A  42
 None
None
None
None
N5Y  A1294 (-4.5A)
 1.15A 3eeyE-4asyA:
undetectable		 3eeyE-4asyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		6 GLY A 248
ASN A 567
ILE A 288
ASN A 548
LEU A 249
THR A 351
 None
NAG  A2001 (-1.9A)
None
None
NAG  A2001 (-4.9A)
None
 1.48A 3eeyE-4b56A:
undetectable		 3eeyE-4b56A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmb GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 GLY A 150
ASN A  10
ILE A 107
LEU A   8
THR A  31
 None
 1.07A 3eeyE-4bmbA:
undetectable		 3eeyE-4bmbA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw5 DFNA

(Bacillus
velezensis) 		PF03060
(NMO) 		5 THR A 356
GLY A 358
ILE A 361
GLY A 365
ASN A 384
 None
None
None
None
FMN  A1753 (-2.8A)
 1.03A 3eeyE-4cw5A:
undetectable		 3eeyE-4cw5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		5 THR A  37
GLY A 262
ASN A 263
ILE A 256
GLY A 253
 None
 1.18A 3eeyE-4djiA:
undetectable		 3eeyE-4djiA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2u ENOYL-COA HYDRATASE

(Rhodobacter
sphaeroides) 		PF16113
(ECH_2) 		5 THR A 148
GLY A 146
ASN A  92
GLY A 269
LEU A 278
 None
 1.19A 3eeyE-4j2uA:
undetectable		 3eeyE-4j2uA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		5 ASP A 157
ILE A  23
GLY A  27
ASN A 155
LEU A  14
 None
 1.14A 3eeyE-4jhiA:
undetectable		 3eeyE-4jhiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii) 		PF00398
(RrnaAD) 		5 ASN A  45
ILE A  49
GLY A  50
ASN A  92
THR A  73
 None
 0.80A 3eeyE-4jxjA:
12.2		 3eeyE-4jxjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		6 GLY A 253
ASP A 377
ILE A 283
GLY A 281
LEU A 407
THR A 437
 None
None
NK  A 501 (-4.4A)
None
None
None
 1.31A 3eeyE-4jz6A:
4.2		 3eeyE-4jz6A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt7 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Anaerococcus
prevotii) 		PF01128
(IspD) 		5 THR A  89
GLY A  92
ILE A  11
THR A 105
THR A 164
 None
 1.17A 3eeyE-4kt7A:
undetectable		 3eeyE-4kt7A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp3 PUTATIVE ORNITHINE
CYCLODEAMINASE

(Staphylococcus
aureus) 		PF02423
(OCD_Mu_crystall) 		5 GLY A 330
ILE A 320
GLY A  17
ASN A 328
LEU A   6
 None
 1.17A 3eeyE-4mp3A:
5.4		 3eeyE-4mp3A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht GENERAL SECRETORY
PATHWAY PROTEIN E

(Vibrio
vulnificus) 		PF00437
(T2SSE) 		5 ASP A 154
ILE A 440
GLY A 478
THR A 438
THR A 487
 None
 1.13A 3eeyE-4phtA:
3.6		 3eeyE-4phtA:
16.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis) 		PF06962
(rRNA_methylase) 		9 THR A  28
GLY A  30
ASN A  31
ASP A  34
ILE A  53
HIS A  80
ASN A 101
LEU A 105
THR A 114
 SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
 0.40A 3eeyE-4pooA:
29.7		 3eeyE-4pooA:
44.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 THR A 223
GLY A 225
ASP A 196
GLY A 280
ASN A 195
 None
 1.07A 3eeyE-4pvvA:
3.7		 3eeyE-4pvvA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi3 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF16010
(CDH-cyt) 		5 THR A  19
ASN A   3
GLY A  53
ASN A   6
THR A  34
 None
PCA  A   1 ( 4.5A)
None
None
None
 1.05A 3eeyE-4qi3A:
undetectable		 3eeyE-4qi3A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY

(Trichormus
variabilis) 		PF13458
(Peripla_BP_6) 		5 GLY A 255
ASP A 202
ILE A 252
LEU A 282
THR A 215
 None
PRO  A 501 ( 4.8A)
None
None
None
 1.17A 3eeyE-4rdcA:
undetectable		 3eeyE-4rdcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 5 GLY B 188
ASN B 155
ILE B 424
GLY B 423
ASN B 270
 None
 1.10A 3eeyE-4tqoB:
undetectable		 3eeyE-4tqoB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx1 ESTERASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		5 GLY A  50
ASP A  91
LEU A  48
THR A  12
THR A 196
 None
 1.07A 3eeyE-4tx1A:
4.1		 3eeyE-4tx1A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A  20
ASN A  44
GLY A 130
ASN A  25
THR A 133
 PO4  A 401 (-3.3A)
PO4  A 401 ( 4.2A)
None
None
None
 1.11A 3eeyE-4u39A:
4.2		 3eeyE-4u39A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 GLY E 237
ASP E 233
GLY E 241
GLN E 145
ASN E 171
 None
 1.13A 3eeyE-4v1dE:
undetectable		 3eeyE-4v1dE:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 GLY A 442
ILE A 520
GLY A 522
HIS A 521
THR A 511
 EDO  A 706 ( 4.5A)
None
None
None
None
 1.15A 3eeyE-4wd1A:
5.0		 3eeyE-4wd1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT
PUTATIVE
OXIDOREDUCTASE
IRON-SULFUR SUBUNIT

(Sulfurisphaera
tokodaii;
Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF00111
(Fer2)
PF01799
(Fer2_2) 		5 GLY C  53
ILE C 136
GLY C 135
ASN C  51
THR A 643
 FES  C 201 (-3.9A)
None
None
FAD  B 301 ( 4.2A)
None
 1.06A 3eeyE-4zohC:
undetectable		 3eeyE-4zohC:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ASP A 320
GLY A 162
HIS A 161
ASN A 192
THR A 265
 None
 0.98A 3eeyE-5a05A:
3.8		 3eeyE-5a05A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0l FIBRONECTIN-BINDING
PROTEIN

(Streptococcus
pyogenes) 		PF08341
(TED) 		5 GLY A 166
ILE A 178
GLY A 177
ASN A 172
LEU A 231
 None
 1.12A 3eeyE-5a0lA:
undetectable		 3eeyE-5a0lA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo sapiens) 		PF12851
(Tet_JBP) 		5 GLY A1282
GLY A1256
ASN A1890
THR A1249
THR A1251
 None
 1.15A 3eeyE-5deuA:
undetectable		 3eeyE-5deuA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 THR A 635
GLY A 668
ASN A 669
ASP A 637
GLY A 632
 None
 1.12A 3eeyE-5dkxA:
undetectable		 3eeyE-5dkxA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium) 		PF00497
(SBP_bac_3) 		5 GLY A 206
GLY A 132
LEU A  53
THR A 111
THR A 113
 None
None
None
GGL  A 301 (-3.9A)
GGL  A 301 (-4.0A)
 1.07A 3eeyE-5eyfA:
undetectable		 3eeyE-5eyfA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuc VHH6

(Camelus
dromedarius) 		PF07686
(V-set) 		5 GLY E 116
GLN E 117
ASN E  21
LEU E  81
THR E 119
 None
 1.17A 3eeyE-5fucE:
undetectable		 3eeyE-5fucE:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		6 GLY A 195
ASN A 512
ILE A 235
ASN A 493
LEU A 196
THR A 298
 None
NAG  A 912 (-1.9A)
None
None
None
None
 1.42A 3eeyE-5gz4A:
undetectable		 3eeyE-5gz4A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzg GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 GLY A 150
ASN A  10
ILE A 107
LEU A   8
THR A  31
 None
 1.07A 3eeyE-5gzgA:
undetectable		 3eeyE-5gzgA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5haf DEUBIQUITINASE SSEL

(Salmonella
enterica) 		no annotation 5 THR A 220
GLY A 186
HIS A 223
GLN A 278
THR A 243
 None
 1.09A 3eeyE-5hafA:
undetectable		 3eeyE-5hafA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASP A 125
ILE A 143
ASN A 124
LEU A 243
THR A 236
 None
 1.10A 3eeyE-5j0aA:
undetectable		 3eeyE-5j0aA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j60 THIOREDOXIN
REDUCTASE

(Gloeobacter
violaceus) 		PF07992
(Pyr_redox_2) 		5 ASP A 314
ILE A  10
GLY A  17
LEU A  29
THR A  77
 None
 1.00A 3eeyE-5j60A:
2.7		 3eeyE-5j60A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ke1 OUTER MEMBRANE
PROTEIN ICSA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF03212
(Pertactin)
PF12951
(PATR) 		5 THR A 661
GLY A 651
ASN A 625
GLY A 655
THR A 688
 None
 0.92A 3eeyE-5ke1A:
undetectable		 3eeyE-5ke1A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]

(Ruminococcus
flavefaciens) 		no annotation 5 THR B 102
ASN B  72
ASP B  74
GLY B  99
ASN B  78
 None
None
CA  B 201 (-3.1A)
None
None
 1.16A 3eeyE-5m2sB:
undetectable		 3eeyE-5m2sB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-8

(Caenorhabditis
elegans) 		PF10220
(Smg8_Smg9) 		5 GLY E  64
ASP E   2
ILE E  41
GLY E  38
LEU E  73
 None
 1.00A 3eeyE-5nkmE:
undetectable		 3eeyE-5nkmE:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 169
ASP A 165
ILE A 123
GLY A 126
THR A 558
 None
 1.02A 3eeyE-5tf0A:
undetectable		 3eeyE-5tf0A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv7 PUTATIVE
PEPTIDOGLYCAN-BINDIN
G/HYDROLYSING
PROTEIN

(Clostridioides
difficile) 		PF01471
(PG_binding_1) 		5 GLY A 134
ILE A 182
GLY A 181
GLN A 172
THR A 187
 None
HGA  A 301 (-3.9A)
None
HGA  A 301 ( 4.6A)
HGA  A 301 (-3.6A)
 1.18A 3eeyE-5tv7A:
undetectable		 3eeyE-5tv7A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubu PUTATIVE
ACETAMIDASE/FORMAMID
ASE

(Yersinia
enterocolitica) 		PF03069
(FmdA_AmdA) 		5 GLY A 188
ASP A 185
GLY A 319
ASN A 186
LEU A 204
 None
 0.95A 3eeyE-5ubuA:
undetectable		 3eeyE-5ubuA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		5 GLY A 124
ASN A 122
GLY A 193
GLN A 411
THR A 131
 None
 1.14A 3eeyE-5uj6A:
undetectable		 3eeyE-5uj6A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2i GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica) 		PF01112
(Asparaginase_2) 		5 GLY A  52
ASP A  44
GLY A 154
ASN A  87
LEU A  65
 None
 0.91A 3eeyE-5v2iA:
undetectable		 3eeyE-5v2iA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 ILE A 563
GLY A 553
ASN A 814
LEU A 517
THR A 531
 None
 1.09A 3eeyE-5wugA:
undetectable		 3eeyE-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgz BETA-GLYCOSIDASE

(uncultured
microorganism) 		no annotation 5 ASP A 152
GLY A 223
ASN A 215
LEU A 158
THR A 220
 None
 0.99A 3eeyE-5xgzA:
undetectable		 3eeyE-5xgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xs7 HEAVY CHAIN OF FAB
1D5

(Mus musculus) 		PF07686
(V-set) 		5 THR H 123
GLY H   9
LEU H  19
THR H  99
THR H  45
 None
 1.01A 3eeyE-5xs7H:
undetectable		 3eeyE-5xs7H:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ASN A 468
ASP A 534
ILE A 421
LEU A 496
THR A 546
 None
 1.11A 3eeyE-5xxoA:
undetectable		 3eeyE-5xxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		no annotation 5 ASP A 108
ILE A  49
ASN A 109
LEU A 104
THR A  40
 MG  A 302 ( 2.5A)
None
DAU  A 301 (-3.2A)
None
None
 0.93A 3eeyE-6b5eA:
undetectable		 3eeyE-6b5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 5 GLY A 215
ASN A 533
ASN A 514
LEU A 216
THR A 318
 None
NAG  A 912 (-1.8A)
None
NAG  A 912 (-4.5A)
None
 1.16A 3eeyE-6c01A:
undetectable		 3eeyE-6c01A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis) 		no annotation 5 ASP A 220
ILE A 214
GLY A 243
HIS A 241
LEU A 255
 None
 1.18A 3eeyE-6co7A:
2.3		 3eeyE-6co7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6de8 BIFUNCTIONAL PROTEIN
FOLD

(Campylobacter
jejuni) 		no annotation 5 THR A 265
ASN A 272
GLY A   6
LEU A 142
THR A 255
 None
 0.99A 3eeyE-6de8A:
4.1		 3eeyE-6de8A:
undetectable