SIMILAR PATTERNS OF AMINO ACIDS FOR 3EEY_D_SAMD300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvw PROTEIN
(CELLOBIOHYDROLASE
II)

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 THR A 306
GLY A 270
GLY A 303
ASN A 307
LEU A 275
 None
 1.19A 3eeyD-1bvwA:
undetectable		 3eeyD-1bvwA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1) 		PF00082
(Peptidase_S8) 		5 GLY A  14
ASN A  17
ILE A  90
GLY A  78
HIS A  75
 None
 1.15A 3eeyD-1dbiA:
undetectable		 3eeyD-1dbiA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyw PHOSPHOTRIESTERASE

(Brevundimonas
diminuta) 		PF02126
(PTE) 		5 ASP A 235
ILE A 228
GLY A 209
GLN A 212
LEU A 252
 None
 1.18A 3eeyD-1eywA:
undetectable		 3eeyD-1eywA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g01 ENDOGLUCANASE

(Bacillus sp.
KSM-635) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		5 GLY A 529
ASP A 494
GLY A 266
GLN A 268
PRO A 533
 None
 1.19A 3eeyD-1g01A:
undetectable		 3eeyD-1g01A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ght TRANSPOSON
GAMMA-DELTA
RESOLVASE

(Escherichia
coli) 		PF00239
(Resolvase) 		5 GLY A   5
ASP A  59
ILE A  93
GLY A  96
LEU A  23
 None
 1.12A 3eeyD-1ghtA:
undetectable		 3eeyD-1ghtA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		5 THR A 170
GLY A 172
ILE A 145
GLY A 144
LEU A 166
 None
 1.13A 3eeyD-1i8dA:
undetectable		 3eeyD-1i8dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdi L-RIBULOSE 5
PHOSPHATE
4-EPIMERASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		5 GLY A 146
ASN A 147
ILE A  93
LEU A  82
THR A  77
 None
 1.18A 3eeyD-1jdiA:
undetectable		 3eeyD-1jdiA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 GLY A  95
ASN A  96
ILE A  62
GLY A 118
LEU A  94
 None
 1.02A 3eeyD-1jftA:
undetectable		 3eeyD-1jftA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqe HISTAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF13489
(Methyltransf_23) 		5 GLY A 237
ASN A 236
GLY A 263
LEU A 240
THR A 245
 None
 1.08A 3eeyD-1jqeA:
12.0		 3eeyD-1jqeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkh MEVALONATE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ASP A  90
ASN A  87
LEU A  82
PRO A  72
THR A 121
 None
 1.00A 3eeyD-1kkhA:
undetectable		 3eeyD-1kkhA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkh MEVALONATE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ASP A  90
ILE A 102
ASN A  87
LEU A  82
PRO A  72
 None
 0.85A 3eeyD-1kkhA:
undetectable		 3eeyD-1kkhA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 ASP C 396
GLY C 433
GLN C 506
LEU C 376
PRO C 373
 None
 1.01A 3eeyD-1n8yC:
undetectable		 3eeyD-1n8yC:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		5 THR A 468
GLY A 437
ASN A 518
ILE A 459
ASN A 467
 None
CA  A 914 ( 4.0A)
None
None
None
 0.60A 3eeyD-1q5aA:
undetectable		 3eeyD-1q5aA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A  66
ASP A 116
ILE A 207
GLY A 208
ASN A 158
 None
 0.87A 3eeyD-1r3nA:
undetectable		 3eeyD-1r3nA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slq VP4

(Rotavirus A) 		PF17477
(Rota_VP4_MID)
PF17478
(VP4_helical) 		5 GLY A 382
ASP A 384
ILE A 379
LEU A 450
PRO A 451
 None
 1.05A 3eeyD-1slqA:
undetectable		 3eeyD-1slqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqh HYPOTHETICAL PROTEIN
CG14615-PA

(Drosophila
melanogaster) 		PF08445
(FR47) 		5 GLY A 250
ILE A 226
GLY A 235
LEU A 251
PRO A 168
 None
 1.16A 3eeyD-1sqhA:
undetectable		 3eeyD-1sqhA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		5 GLY A 119
ASP A 144
ILE A 116
GLY A 115
LEU A  96
 None
 0.97A 3eeyD-1v4vA:
4.1		 3eeyD-1v4vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4i OUTER CAPSID PROTEIN
VP4

(Rotavirus A) 		PF17477
(Rota_VP4_MID) 		5 GLY A 382
ASP A 384
ILE A 379
LEU A 450
PRO A 451
 None
 0.97A 3eeyD-2b4iA:
undetectable		 3eeyD-2b4iA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 GLY A 214
ASN A 213
GLY A  81
GLN A  43
ASN A 220
 None
 0.93A 3eeyD-2eb5A:
undetectable		 3eeyD-2eb5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9z CHEMOTAXIS PROTEIN
CHEC

(Thermotoga
maritima) 		PF04509
(CheC) 		5 GLY A 114
ASN A 115
ILE A  78
GLY A  80
PRO A 138
 None
 1.11A 3eeyD-2f9zA:
undetectable		 3eeyD-2f9zA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLY A 196
ASN A  27
ILE A 211
GLY A 145
HIS A 119
 None
None
None
None
ZN  A 561 ( 3.1A)
 0.85A 3eeyD-2it4A:
undetectable		 3eeyD-2it4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwo MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 THR A1899
ILE A1862
GLY A1851
HIS A1898
LEU A1904
 None
 1.08A 3eeyD-2iwoA:
undetectable		 3eeyD-2iwoA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3b NUCLEASE

(Nostoc sp. PCC
7120) 		PF01223
(Endonuclease_NS) 		5 THR A  75
GLY A 123
GLN A 150
ASN A  70
LEU A  67
 None
MG  A 303 ( 4.6A)
MG  A 303 ( 4.9A)
None
None
 1.08A 3eeyD-2o3bA:
undetectable		 3eeyD-2o3bA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q42 PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 2

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 THR A 113
GLY A 111
GLY A 130
HIS A  54
LEU A 141
 None
None
None
ZN  A 700 (-3.2A)
None
 1.15A 3eeyD-2q42A:
undetectable		 3eeyD-2q42A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 THR A 111
GLY A 109
GLY A 126
HIS A  53
LEU A 137
 None
None
None
FE  A 253 (-3.3A)
None
 1.12A 3eeyD-2qedA:
undetectable		 3eeyD-2qedA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 GLY A 225
ASP A 289
ILE A 212
GLY A 213
THR A 218
 None
 0.99A 3eeyD-2x3kA:
undetectable		 3eeyD-2x3kA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		6 THR A 435
ASP A 437
GLY A 380
ASN A 436
LEU A 328
THR A  92
 None
 1.18A 3eeyD-2xijA:
undetectable		 3eeyD-2xijA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		PF00069
(Pkinase) 		5 THR A 637
ILE A 643
GLY A 642
HIS A 641
LEU A 662
 None
 1.17A 3eeyD-2zmcA:
undetectable		 3eeyD-2zmcA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		5 THR A 220
GLY A 222
ASP A 193
GLY A 273
ASN A 192
 AMP  A 502 (-3.4A)
AMP  A 502 (-3.5A)
None
None
None
 0.91A 3eeyD-3b1rA:
3.3		 3eeyD-3b1rA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		5 ASN A  60
ILE A  53
GLY A  80
GLN A  82
LEU A 102
 None
SAM  A 300 (-4.0A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
SAM  A 300 ( 3.8A)
 1.20A 3eeyD-3eeyA:
36.2		 3eeyD-3eeyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		12 THR A  28
GLY A  30
ASN A  31
ASP A  34
ILE A  53
GLY A  80
HIS A  81
GLN A  82
ASN A  98
LEU A 102
PRO A 103
THR A 111
 SAM  A 300 (-4.1A)
SAM  A 300 (-3.4A)
SAM  A 300 (-4.7A)
SAM  A 300 (-3.9A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.5A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 3.8A)
SO4  A 302 (-4.3A)
SAM  A 300 (-4.4A)
 0.19A 3eeyD-3eeyA:
36.2		 3eeyD-3eeyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		5 ASN A 624
ILE A 605
GLY A 606
LEU A 371
PRO A 368
 None
 1.13A 3eeyD-3eqnA:
undetectable		 3eeyD-3eqnA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbq CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13786
(DUF4179) 		5 THR A 105
ASP A  50
GLY A  83
HIS A 107
LEU A  76
 None
 1.05A 3eeyD-3fbqA:
undetectable		 3eeyD-3fbqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ide CAPSID PROTEIN VP2

(Infectious
pancreatic
necrosis virus) 		PF01766
(Birna_VP2) 		5 THR A 168
GLY A  58
ILE A  14
LEU A  98
PRO A  60
 None
 1.15A 3eeyD-3ideA:
undetectable		 3eeyD-3ideA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE

(Streptomyces
coelicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 122
ASP A 124
ILE A  58
GLY A 402
ASN A  83
 None
 1.16A 3eeyD-3krtA:
5.6		 3eeyD-3krtA:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lby PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1697C

(Streptococcus
mutans) 		PF06962
(rRNA_methylase) 		10 THR A  27
GLY A  29
ASN A  30
ASP A  33
GLY A  75
HIS A  76
GLN A  77
ASN A  93
LEU A  97
THR A 106
 SAH  A4630 (-4.2A)
SAH  A4630 (-3.6A)
None
None
SAH  A4630 (-3.3A)
SAH  A4630 (-3.1A)
SAH  A4630 (-3.8A)
None
SAH  A4630 (-3.9A)
SAH  A4630 (-4.5A)
 0.65A 3eeyD-3lbyA:
30.6		 3eeyD-3lbyA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		5 THR A  27
GLY A  29
ASN A  30
GLY A  75
HIS A  76
 None
 0.92A 3eeyD-3mtiA:
27.0		 3eeyD-3mtiA:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		6 THR A  27
GLY A  29
ASP A  33
GLY A  75
HIS A  76
ASN A  93
 None
 0.56A 3eeyD-3mtiA:
27.0		 3eeyD-3mtiA:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		5 GLY K  42
ASP K 418
ILE K  73
GLY K  72
LEU K 414
 None
 1.09A 3eeyD-3mvdK:
undetectable		 3eeyD-3mvdK:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		5 GLY A2248
ILE A2154
GLY A2153
PRO A2246
THR A2252
 None
 1.10A 3eeyD-3opeA:
undetectable		 3eeyD-3opeA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 5 THR A 216
GLY A 198
ASN A 178
ASP A 196
GLY A 257
 None
CA  A 409 (-4.2A)
None
None
CA  A 412 (-4.3A)
 1.16A 3eeyD-3p4gA:
undetectable		 3eeyD-3p4gA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 ASN A 695
ILE A 519
GLY A 518
ASN A 688
THR A 676
 None
 1.14A 3eeyD-3psfA:
undetectable		 3eeyD-3psfA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 GLY A 744
ASP A 256
ILE A 741
GLY A 740
HIS A 260
 None
 1.15A 3eeyD-3qr1A:
undetectable		 3eeyD-3qr1A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubr CYTOCHROME C-552

(Shewanella
oneidensis) 		PF02335
(Cytochrom_C552) 		5 THR A 154
GLY A 156
ASP A 126
GLY A  90
ASN A 153
 None
HEC  A 472 (-4.0A)
None
HEC  A 473 ( 4.4A)
None
 1.11A 3eeyD-3ubrA:
undetectable		 3eeyD-3ubrA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voh CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		5 THR A 290
GLY A 254
GLY A 287
ASN A 291
LEU A 259
 None
 1.11A 3eeyD-3vohA:
undetectable		 3eeyD-3vohA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp9 ICE-BINDING PROTEIN

(Colwellia sp.
SLW05) 		PF11999
(DUF3494) 		5 THR A 108
ILE A 104
GLY A 105
ASN A 129
PRO A 111
 None
 1.01A 3eeyD-3wp9A:
undetectable		 3eeyD-3wp9A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 GLY A 711
ASN A 710
ASP A 738
ASN A 677
PRO A 389
 None
 1.19A 3eeyD-3zhrA:
undetectable		 3eeyD-3zhrA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a05 CELLOBIOHYDROLASE
FAMILY 6

(Chaetomium
thermophilum) 		PF01341
(Glyco_hydro_6) 		5 THR A 332
GLY A 296
GLY A 329
ASN A 333
LEU A 301
 None
 1.17A 3eeyD-4a05A:
undetectable		 3eeyD-4a05A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 GLY A  19
ASN A  20
GLY A  15
HIS A  11
LEU A  34
 None
 1.14A 3eeyD-4anjA:
undetectable		 3eeyD-4anjA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au0 EXOGLUCANASE 2

(Trichoderma
reesei) 		PF01341
(Glyco_hydro_6) 		5 THR A 301
GLY A 265
GLY A 298
ASN A 302
LEU A 270
 None
 1.13A 3eeyD-4au0A:
undetectable		 3eeyD-4au0A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 ASN A 527
ASP A 525
GLY A 505
LEU A 459
THR A 473
 None
 1.15A 3eeyD-4byfA:
undetectable		 3eeyD-4byfA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF00037
(Fer4)
PF01058
(Oxidored_q6) 		5 GLY B 207
ILE B 254
GLY B 170
LEU B 235
THR B 232
 SF4  B1275 ( 4.0A)
SF4  B1275 ( 4.6A)
None
SF4  B1275 (-3.7A)
SF4  B1275 (-3.4A)
 1.18A 3eeyD-4ci0B:
undetectable		 3eeyD-4ci0B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw5 DFNA

(Bacillus
velezensis) 		PF03060
(NMO) 		5 THR A 356
GLY A 358
ILE A 361
GLY A 365
ASN A 384
 None
None
None
None
FMN  A1753 (-2.8A)
 1.04A 3eeyD-4cw5A:
undetectable		 3eeyD-4cw5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A 174
ILE A 171
GLY A 203
ASN A 125
LEU A 152
 None
 1.05A 3eeyD-4dgjA:
undetectable		 3eeyD-4dgjA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		5 THR A  37
GLY A 262
ASN A 263
ILE A 256
GLY A 253
 None
 1.18A 3eeyD-4djiA:
undetectable		 3eeyD-4djiA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1u DEPHOSPHO-COA KINASE

(Burkholderia
vietnamiensis) 		PF01121
(CoaE) 		5 THR A  39
GLY A  43
ILE A  34
LEU A  44
THR A  87
 None
CL  A 304 (-3.6A)
None
CL  A 304 (-4.0A)
None
 1.14A 3eeyD-4i1uA:
undetectable		 3eeyD-4i1uA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5u CHIMERIC CEL6A

(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		PF01341
(Glyco_hydro_6) 		5 THR A 302
GLY A 266
GLY A 299
ASN A 303
LEU A 271
 None
 1.17A 3eeyD-4i5uA:
undetectable		 3eeyD-4i5uA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbd PROLINE RACEMASE

(Pseudomonas
putida) 		PF05544
(Pro_racemase) 		5 GLY A 127
ILE A  93
LEU A 123
PRO A 107
THR A 130
 None
 1.14A 3eeyD-4jbdA:
undetectable		 3eeyD-4jbdA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jci PROLINE RACEMASE

(Chromohalobacter
salexigens) 		PF05544
(Pro_racemase) 		5 GLY A 127
ILE A  93
LEU A 123
PRO A 107
THR A 130
 None
 1.13A 3eeyD-4jciA:
undetectable		 3eeyD-4jciA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		5 ASP A 157
ILE A  23
GLY A  27
ASN A 155
LEU A  14
 None
 1.15A 3eeyD-4jhiA:
undetectable		 3eeyD-4jhiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 GLY A 253
ASP A 377
ILE A 283
GLY A 281
LEU A 407
 None
None
NK  A 501 (-4.4A)
None
None
 1.12A 3eeyD-4jz6A:
4.5		 3eeyD-4jz6A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 GLY A 253
ASP A 377
ILE A 283
GLY A 281
THR A 437
 None
None
NK  A 501 (-4.4A)
None
None
 1.09A 3eeyD-4jz6A:
4.5		 3eeyD-4jz6A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksi LEUCINE
AMINOPEPTIDASE 1,
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 THR A 426
GLY A 349
GLY A 406
ASN A 425
LEU A 353
 None
MG  A 601 ( 4.8A)
None
None
None
 1.18A 3eeyD-4ksiA:
undetectable		 3eeyD-4ksiA:
18.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis) 		PF06962
(rRNA_methylase) 		10 THR A  28
GLY A  30
ASN A  31
ASP A  34
ILE A  53
HIS A  80
ASN A 101
LEU A 105
PRO A 106
THR A 114
 SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-4.1A)
 0.43A 3eeyD-4pooA:
30.0		 3eeyD-4pooA:
44.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 THR A 223
GLY A 225
ASP A 196
GLY A 280
ASN A 195
 None
 1.06A 3eeyD-4pvvA:
3.7		 3eeyD-4pvvA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Chromobacterium
violaceum) 		PF04348
(LppC) 		5 GLY A 362
ASP A 358
GLY A 367
LEU A 376
PRO A 377
 None
 1.17A 3eeyD-4pyrA:
3.2		 3eeyD-4pyrA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi3 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF16010
(CDH-cyt) 		5 THR A  19
ASN A   3
GLY A  53
ASN A   6
THR A  34
 None
PCA  A   1 ( 4.5A)
None
None
None
 1.03A 3eeyD-4qi3A:
undetectable		 3eeyD-4qi3A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 5 GLY B 188
ASN B 155
ILE B 424
GLY B 423
ASN B 270
 None
 1.09A 3eeyD-4tqoB:
undetectable		 3eeyD-4tqoB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A  20
ASN A  44
GLY A 130
ASN A  25
THR A 133
 PO4  A 401 (-3.3A)
PO4  A 401 ( 4.2A)
None
None
None
 1.10A 3eeyD-4u39A:
4.5		 3eeyD-4u39A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 GLY E 237
ASP E 233
GLY E 241
GLN E 145
ASN E 171
 None
 1.14A 3eeyD-4v1dE:
undetectable		 3eeyD-4v1dE:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 GLY A 442
ILE A 520
GLY A 522
HIS A 521
THR A 511
 EDO  A 706 ( 4.5A)
None
None
None
None
 1.16A 3eeyD-4wd1A:
5.9		 3eeyD-4wd1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella ovis) 		PF00106
(adh_short) 		5 GLY A  75
ASP A  72
ILE A  35
LEU A 130
PRO A 129
 None
 1.17A 3eeyD-4z0tA:
9.9		 3eeyD-4z0tA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase) 		5 ASP A 264
ILE A 314
GLY A 273
LEU A 303
PRO A 302
 None
 1.20A 3eeyD-4zcfA:
3.6		 3eeyD-4zcfA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT
PUTATIVE
OXIDOREDUCTASE
IRON-SULFUR SUBUNIT

(Sulfurisphaera
tokodaii;
Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF00111
(Fer2)
PF01799
(Fer2_2) 		5 GLY C  53
ILE C 136
GLY C 135
ASN C  51
THR A 643
 FES  C 201 (-3.9A)
None
None
FAD  B 301 ( 4.2A)
None
 1.08A 3eeyD-4zohC:
undetectable		 3eeyD-4zohC:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ASP A 320
GLY A 162
HIS A 161
ASN A 192
THR A 265
 None
 0.99A 3eeyD-5a05A:
3.0		 3eeyD-5a05A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		5 GLY A 611
ILE A 870
GLY A 773
GLN A 866
PRO A 999
 None
 1.14A 3eeyD-5d0fA:
undetectable		 3eeyD-5d0fA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 THR A 635
GLY A 668
ASN A 669
ASP A 637
GLY A 632
 None
 1.14A 3eeyD-5dkxA:
undetectable		 3eeyD-5dkxA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		6 THR A 100
ILE A 114
GLY A 115
HIS A 116
ASN A 135
LEU A 105
 None
 1.49A 3eeyD-5dldA:
4.0		 3eeyD-5dldA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn6 ATP SYNTHASE SUBUNIT
ALPHA

(Paracoccus
denitrificans) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 GLY A 112
ASN A 113
ILE A 203
GLY A 255
PRO A 114
 None
 1.12A 3eeyD-5dn6A:
2.6		 3eeyD-5dn6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enz UDP-GLCNAC
2-EPIMERASE

(Staphylococcus
aureus) 		PF02350
(Epimerase_2) 		6 THR A 100
ILE A 114
GLY A 115
HIS A 116
ASN A 135
LEU A 105
 None
 1.50A 3eeyD-5enzA:
3.8		 3eeyD-5enzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5j FERREDOXIN--NADP
REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1) 		5 GLY A 152
ASN A  27
ILE A  96
GLY A 110
HIS A  61
 None
 1.20A 3eeyD-5h5jA:
4.7		 3eeyD-5h5jA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hos CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		6 GLY A 134
ILE A 205
GLY A 246
ASN A 137
LEU A 135
THR A 175
 None
 1.48A 3eeyD-5hosA:
undetectable		 3eeyD-5hosA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASP A 125
ILE A 143
ASN A 124
LEU A 243
THR A 236
 None
 1.06A 3eeyD-5j0aA:
undetectable		 3eeyD-5j0aA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1b CELL WALL ASSEMBLY
REGULATOR SMI1

(Saccharomyces
cerevisiae) 		PF09346
(SMI1_KNR4) 		5 ASP A 144
ILE A 249
GLY A 250
LEU A 158
THR A 242
 None
 1.15A 3eeyD-5j1bA:
undetectable		 3eeyD-5j1bA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j60 THIOREDOXIN
REDUCTASE

(Gloeobacter
violaceus) 		PF07992
(Pyr_redox_2) 		5 ASP A 314
ILE A  10
GLY A  17
LEU A  29
THR A  77
 None
 1.13A 3eeyD-5j60A:
2.9		 3eeyD-5j60A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd6 MGS-MCHE2

(uncultured
bacterium) 		PF00561
(Abhydrolase_1) 		5 GLY A 118
ASN A 183
ILE A 113
GLY A  89
LEU A 119
 None
 1.19A 3eeyD-5jd6A:
2.1		 3eeyD-5jd6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk7 PROTEIN VPRBP

(Homo sapiens) 		no annotation 5 THR C1213
ASN C1216
GLY C1194
HIS C1201
PRO C1217
 None
 1.20A 3eeyD-5jk7C:
undetectable		 3eeyD-5jk7C:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 GLY A 481
ASP A 182
ILE A 463
GLY A 287
PRO A 478
 None
 1.20A 3eeyD-5lhkA:
undetectable		 3eeyD-5lhkA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]

(Ruminococcus
flavefaciens) 		no annotation 5 THR B 102
ASN B  72
ASP B  74
GLY B  99
ASN B  78
 None
None
CA  B 201 (-3.1A)
None
None
 1.15A 3eeyD-5m2sB:
undetectable		 3eeyD-5m2sB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A 121
ILE A  88
GLY A  87
ASN A 138
LEU A 119
 None
 1.13A 3eeyD-5n9xA:
3.0		 3eeyD-5n9xA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 THR A 347
GLY A 362
ASN A 386
ILE A 330
GLY A 287
 None
 1.19A 3eeyD-5olsA:
undetectable		 3eeyD-5olsA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 169
ASP A 165
ILE A 123
GLY A 126
THR A 558
 None
 1.01A 3eeyD-5tf0A:
undetectable		 3eeyD-5tf0A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubu PUTATIVE
ACETAMIDASE/FORMAMID
ASE

(Yersinia
enterocolitica) 		PF03069
(FmdA_AmdA) 		5 GLY A 188
ASP A 185
GLY A 319
ASN A 186
LEU A 204
 None
 1.03A 3eeyD-5ubuA:
undetectable		 3eeyD-5ubuA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubv ATPASE DOMAIN OF
I-AAA PROTEASE

(Thermothelomyces
thermophila) 		no annotation 5 GLY A 206
ILE A 181
GLY A  10
LEU A 207
THR A  50
 None
ADP  A 302 ( 4.4A)
None
None
ADP  A 302 (-4.3A)
 1.16A 3eeyD-5ubvA:
undetectable		 3eeyD-5ubvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcy GLUCANASE

(Phanerochaete
chrysosporium) 		PF01341
(Glyco_hydro_6) 		5 THR A 296
GLY A 260
GLY A 293
ASN A 297
LEU A 265
 None
 1.20A 3eeyD-5xcyA:
undetectable		 3eeyD-5xcyA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1

(Homo sapiens) 		PF00514
(Arm) 		5 THR A 436
GLY A 392
ASP A 432
GLY A 441
LEU A 397
 None
 1.19A 3eeyD-5xgcA:
undetectable		 3eeyD-5xgcA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3x BETA-XYLANASE

(Caldicellulosiruptor
owensensis) 		no annotation 5 GLY A 298
ILE A  38
GLY A  36
LEU A 319
PRO A 318
 None
 1.20A 3eeyD-5y3xA:
undetectable		 3eeyD-5y3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1

(Saccharomyces
cerevisiae) 		no annotation 5 GLY A 481
ILE A 456
GLY A 285
LEU A 482
THR A 325
 None
ATP  A 801 ( 4.4A)
ATP  A 801 ( 4.2A)
None
ATP  A 801 (-4.3A)
 1.12A 3eeyD-6az0A:
undetectable		 3eeyD-6az0A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		no annotation 5 ASP A 108
ILE A  49
ASN A 109
LEU A 104
THR A  40
 MG  A 302 ( 2.5A)
None
DAU  A 301 (-3.2A)
None
None
 1.03A 3eeyD-6b5eA:
undetectable		 3eeyD-6b5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis) 		no annotation 5 ASP A 220
ILE A 214
GLY A 243
HIS A 241
LEU A 255
 None
 1.14A 3eeyD-6co7A:
2.8		 3eeyD-6co7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Rattus
norvegicus) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 ASN A  73
ASP A 161
GLN A 165
 None
 0.82A 3eeyD-1b4pA:
undetectable		 3eeyD-1b4pA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmz PROTEIN (GAIP
(G-ALPHA
INTERACTING)
PROTEIN)

(Homo sapiens) 		PF00615
(RGS) 		3 ASN A 166
ASP A 179
GLN A 183
 None
 0.77A 3eeyD-1cmzA:
undetectable		 3eeyD-1cmzA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f59 IMPORTIN BETA-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 ASN A  63
ASP A 160
GLN A 159
 None
 0.72A 3eeyD-1f59A:
undetectable		 3eeyD-1f59A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fig IGG1-KAPPA 1F7 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASN H  60
ASP H  86
GLN H  83
 None
 0.83A 3eeyD-1figH:
undetectable		 3eeyD-1figH:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq8 PECTINESTERASE

(Daucus carota) 		PF01095
(Pectinesterase) 		3 ASN A 183
ASP A 136
GLN A 113
 None
CAC  A 501 (-3.2A)
CAC  A 501 ( 4.8A)
 0.83A 3eeyD-1gq8A:
undetectable		 3eeyD-1gq8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		3 ASN P 334
ASP P 397
GLN P 393
 None
CA  P 501 (-2.6A)
CA  P 501 (-3.6A)
 0.75A 3eeyD-1h71P:
undetectable		 3eeyD-1h71P:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7k CATALASE

(Proteus
mirabilis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ASN A 223
ASP A 178
GLN A 174
 None
 0.73A 3eeyD-1h7kA:
undetectable		 3eeyD-1h7kA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		3 ASN A 152
ASP A  31
GLN A  30
 None
 0.76A 3eeyD-1i2oA:
undetectable		 3eeyD-1i2oA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqc DI-HEME PEROXIDASE

(Nitrosomonas
europaea) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 ASN A 268
ASP A 170
GLN A 169
 None
 0.81A 3eeyD-1iqcA:
undetectable		 3eeyD-1iqcA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT
QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
9 KDA SUBUNIT

(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII)
PF08992
(QH-AmDH_gamma) 		3 ASN C  56
ASP C  49
GLN A 129
 None
 0.73A 3eeyD-1pbyC:
undetectable		 3eeyD-1pbyC:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 ASN A  63
ASP A 160
GLN A 159
 None
 0.84A 3eeyD-1qgrA:
undetectable		 3eeyD-1qgrA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		3 ASN A  24
ASP A  55
GLN A  51
 None
 0.72A 3eeyD-1vf8A:
undetectable		 3eeyD-1vf8A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE

(Sarocladium
strictum) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 ASN A  30
ASP A 431
GLN A 408
 None
 0.84A 3eeyD-1zr6A:
undetectable		 3eeyD-1zr6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ASN A 375
ASP A 208
GLN A 424
 None
 0.79A 3eeyD-2b24A:
undetectable		 3eeyD-2b24A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cde INKT-TCR

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 ASN A  59
ASP A  84
GLN A  81
 None
 0.71A 3eeyD-2cdeA:
undetectable		 3eeyD-2cdeA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1

(Salmonella
enterica) 		no annotation 3 ASN A 158
ASP A 152
GLN A 148
 None
 0.77A 3eeyD-2d4yA:
undetectable		 3eeyD-2d4yA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb6 CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02635
(DrsE) 		3 ASN A  15
ASP A  54
GLN A  56
 None
 0.78A 3eeyD-2fb6A:
undetectable		 3eeyD-2fb6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		3 ASN A 230
ASP A 301
GLN A  15
 None
None
MLR  A2913 ( 3.9A)
 0.79A 3eeyD-2fncA:
undetectable		 3eeyD-2fncA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0t CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		3 ASN A  87
ASP A 210
GLN A 241
 None
None
EDO  A 341 (-3.1A)
 0.83A 3eeyD-2g0tA:
4.8		 3eeyD-2g0tA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		3 ASN A 199
ASP A 163
GLN A  28
 None
 0.78A 3eeyD-2gjxA:
undetectable		 3eeyD-2gjxA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens;
Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2)
no annotation 		3 ASN I 199
ASP I 163
GLN A  28
 None
 0.84A 3eeyD-2gk1I:
undetectable		 3eeyD-2gk1I:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 ASN A 176
ASP A 212
GLN A 677
 None
 0.78A 3eeyD-2ipcA:
2.6		 3eeyD-2ipcA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA

(Desulfovibrio
vulgaris) 		PF02335
(Cytochrom_C552) 		3 ASN A  83
ASP A 127
GLN A 126
 None
HEM  A1003 (-3.5A)
None
 0.83A 3eeyD-2j7aA:
undetectable		 3eeyD-2j7aA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE

(Escherichia
coli) 		PF01204
(Trehalase) 		3 ASN A  69
ASP A  78
GLN A  82
 None
 0.70A 3eeyD-2jf4A:
undetectable		 3eeyD-2jf4A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN

(Rattus
norvegicus) 		PF00012
(HSP70) 		3 ASN A 168
ASP A 160
GLN A 156
 None
 0.77A 3eeyD-2v7zA:
undetectable		 3eeyD-2v7zA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 ASN A 260
ASP A 538
GLN A 541
 None
 0.46A 3eeyD-2xn1A:
undetectable		 3eeyD-2xn1A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 ASN X  92
ASP X  83
GLN X  79
 None
 0.73A 3eeyD-2zkmX:
undetectable		 3eeyD-2zkmX:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 3 ASN A 308
ASP A 258
GLN A 235
 None
 0.78A 3eeyD-3a0fA:
undetectable		 3eeyD-3a0fA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxz PREPROTEIN
TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF07517
(SecA_DEAD) 		3 ASN A 179
ASP A 212
GLN A 570
 None
 0.80A 3eeyD-3bxzA:
2.1		 3eeyD-3bxzA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A A SUBUNIT

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		3 ASN A 535
ASP A 570
GLN A 571
 None
 0.66A 3eeyD-3c5wA:
undetectable		 3eeyD-3c5wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgg SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		3 ASN A  24
ASP A  86
GLN A  85
 None
 0.65A 3eeyD-3cggA:
14.1		 3eeyD-3cggA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbo UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF02604
(PhdYeFM_antitox)
PF01850
(PIN) 		3 ASN A  76
ASP B 133
GLN B 132
 None
 0.74A 3eeyD-3dboA:
undetectable		 3eeyD-3dboA:
19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		3 ASN A  33
ASP A  52
GLN A  54
 SAM  A 300 (-4.0A)
SAM  A 300 (-2.9A)
SAM  A 300 (-3.8A)
 0.02A 3eeyD-3eeyA:
36.2		 3eeyD-3eeyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtu GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 ASN B  77
ASP B 165
GLN B 169
 None
 0.82A 3eeyD-3gtuB:
undetectable		 3eeyD-3gtuB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 ASN B 191
ASP B 454
GLN B 455
 None
 0.81A 3eeyD-3h0gB:
undetectable		 3eeyD-3h0gB:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		3 ASN P 349
ASP P 412
GLN P 408
 None
CA  P 485 (-2.7A)
CA  P 485 (-3.5A)
 0.80A 3eeyD-3hbuP:
undetectable		 3eeyD-3hbuP:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		3 ASN A  99
ASP A 217
GLN A 182
 LLP  A 243 ( 3.3A)
LLP  A 243 ( 2.9A)
LLP  A 243 ( 4.0A)
 0.83A 3eeyD-3hvyA:
5.5		 3eeyD-3hvyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP6

(Saccharomyces
cerevisiae) 		PF01918
(Alba) 		3 ASN A 105
ASP A 144
GLN A  77
 None
 0.78A 3eeyD-3iabA:
5.2		 3eeyD-3iabA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum) 		PF13458
(Peripla_BP_6) 		3 ASN A  78
ASP A 121
GLN A 124
 None
 0.81A 3eeyD-3ipcA:
2.8		 3eeyD-3ipcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 ASN A 480
ASP A 446
GLN A 445
 U  C  36 ( 3.4A)
A  C  35 ( 4.0A)
C  C  65 ( 4.6A)
 0.79A 3eeyD-3jb9A:
undetectable		 3eeyD-3jb9A:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN

(Rhodobacter
sphaeroides) 		PF02126
(PTE) 		3 ASN A  77
ASP A 270
GLN A 271
 None
None
DTV  A 402 ( 4.0A)
 0.74A 3eeyD-3k2gA:
undetectable		 3eeyD-3k2gA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lby PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1697C

(Streptococcus
mutans) 		PF06962
(rRNA_methylase) 		3 ASN A  32
ASP A  48
GLN A  50
 None
SAH  A4630 (-2.9A)
SAH  A4630 (-3.8A)
 0.35A 3eeyD-3lbyA:
30.6		 3eeyD-3lbyA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		3 ASN A  32
ASP A  48
GLN A  50
 None
 0.33A 3eeyD-3mtiA:
27.0		 3eeyD-3mtiA:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II

(Streptococcus
suis) 		PF00155
(Aminotran_1_2) 		3 ASN A  57
ASP A 259
GLN A 263
 SO4  A 401 ( 3.0A)
None
None
 0.84A 3eeyD-3op7A:
3.9		 3eeyD-3op7A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bacillus
halodurans) 		PF00171
(Aldedh) 		3 ASN A 482
ASP A 135
GLN A 136
 None
 0.72A 3eeyD-3prlA:
3.9		 3eeyD-3prlA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1) 		PF01663
(Phosphodiest) 		3 ASN A 280
ASP A 290
GLN A 288
 None
 0.68A 3eeyD-3q3qA:
undetectable		 3eeyD-3q3qA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 ASN A 143
ASP A 476
GLN A 433
 None
 0.80A 3eeyD-3s29A:
undetectable		 3eeyD-3s29A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		3 ASN A 216
ASP A 201
GLN A 197
 None
 0.80A 3eeyD-3tc1A:
undetectable		 3eeyD-3tc1A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 ASN A 566
ASP A 574
GLN A 612
 None
 0.67A 3eeyD-3uszA:
undetectable		 3eeyD-3uszA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		3 ASN A  99
ASP A  49
GLN A  52
 None
 0.71A 3eeyD-3vlaA:
undetectable		 3eeyD-3vlaA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE

(Aquifex
aeolicus) 		PF03841
(SelA) 		3 ASN A  81
ASP A 284
GLN A 291
 None
LLP  A 285 ( 4.3A)
None
 0.77A 3eeyD-3w1hA:
3.9		 3eeyD-3w1hA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		3 ASN A 242
ASP A 377
GLN A 381
 None
 0.75A 3eeyD-4a5wA:
undetectable		 3eeyD-4a5wA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 ASN A 429
ASP A 353
GLN A 352
 None
 0.71A 3eeyD-4b90A:
undetectable		 3eeyD-4b90A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 ASN A 429
ASP A 353
GLN A 352
 None
 0.79A 3eeyD-4b92A:
undetectable		 3eeyD-4b92A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 ASN A 196
ASP A 154
GLN A 180
 None
 0.81A 3eeyD-4cztA:
undetectable		 3eeyD-4cztA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drt DE NOVO DESIGNED
SERINE HYDROLASE,
OR89

(synthetic
construct) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 ASN A  81
ASP A 111
GLN A 110
 None
 0.77A 3eeyD-4drtA:
undetectable		 3eeyD-4drtA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e37 CATALASE

(Pseudomonas
aeruginosa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ASN A 224
ASP A 179
GLN A 175
 None
 0.76A 3eeyD-4e37A:
undetectable		 3eeyD-4e37A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX

(Bacillus cereus) 		PF00091
(Tubulin) 		3 ASN A 202
ASP A  59
GLN A  58
 None
 0.72A 3eeyD-4ei8A:
4.9		 3eeyD-4ei8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 3 ASN A  76
ASP A 182
GLN A  49
 None
 0.67A 3eeyD-4fyeA:
undetectable		 3eeyD-4fyeA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbo E7

(Thermobifida
fusca) 		PF03067
(LPMO_10) 		3 ASN A  77
ASP A 120
GLN A 104
 IOD  A 311 (-3.5A)
None
None
 0.81A 3eeyD-4gboA:
undetectable		 3eeyD-4gboA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jin RIO-TYPE
SERINE/THREONINE-PRO
TEIN KINASE RIO1

(Archaeoglobus
fulgidus) 		PF01163
(RIO1) 		3 ASN A  62
ASP A 212
GLN A 215
 None
1L7  A 301 (-3.6A)
None
 0.74A 3eeyD-4jinA:
undetectable		 3eeyD-4jinA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)

(Streptococcus
agalactiae) 		PF10425
(SdrG_C_C) 		3 ASN A 423
ASP A 393
GLN A 397
 None
 0.53A 3eeyD-4mboA:
undetectable		 3eeyD-4mboA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		3 ASN A 305
ASP A 332
GLN A 330
 ASN  A 305 (-0.6A)
ASP  A 332 ( 0.5A)
GLN  A 330 ( 0.6A)
 0.80A 3eeyD-4mwtA:
undetectable		 3eeyD-4mwtA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmu THIOL-DISULFIDE
OXIDOREDUCTASE RESA

(Bacillus
anthracis) 		PF00578
(AhpC-TSA) 		3 ASN A  38
ASP A  96
GLN A  99
 None
 0.84A 3eeyD-4nmuA:
undetectable		 3eeyD-4nmuA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN

(Sulfolobus
acidocaldarius) 		PF01266
(DAO) 		3 ASN A 294
ASP A 183
GLN A 233
 GRG  A 503 (-4.6A)
GRG  A 502 (-3.4A)
None
 0.80A 3eeyD-4opuA:
2.9		 3eeyD-4opuA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR

(Escherichia
coli) 		PF00392
(GntR)
PF07729
(FCD) 		3 ASN A 133
ASP A  19
GLN A  15
 None
 0.80A 3eeyD-4p9fA:
undetectable		 3eeyD-4p9fA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Verminephrobacter
eiseniae) 		PF03480
(DctP) 		3 ASN A 219
ASP A 230
GLN A 231
 EAX  A 401 (-2.8A)
None
None
 0.79A 3eeyD-4p9kA:
undetectable		 3eeyD-4p9kA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pp1 HEAVY CHAIN OF FAB
FRAGMENT OF MAB 5H8

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASN D  60
ASP D  89
GLN D  86
 None
 0.74A 3eeyD-4pp1D:
undetectable		 3eeyD-4pp1D:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q66 PROTEIN BCH1

(Saccharomyces
cerevisiae) 		no annotation 3 ASN K 716
ASP K 708
GLN K 704
 None
 0.74A 3eeyD-4q66K:
undetectable		 3eeyD-4q66K:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6i T-CELL SURFACE
GLYCOPROTEIN CD4

(Homo sapiens) 		PF00047
(ig)
PF05790
(C2-set) 		3 ASN C 137
ASP C 153
GLN C 152
 None
 0.80A 3eeyD-4q6iC:
undetectable		 3eeyD-4q6iC:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yds FLAGELLA-RELATED
PROTEIN H

(Sulfolobus
acidocaldarius) 		PF06745
(ATPase) 		3 ASN A 148
ASP A 142
GLN A 138
 None
 0.76A 3eeyD-4ydsA:
3.8		 3eeyD-4ydsA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		3 ASN A1920
ASP A1810
GLN A1809
 None
 0.77A 3eeyD-4yknA:
undetectable		 3eeyD-4yknA:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zel DOPAMINE
BETA-HYDROXYLASE

(Homo sapiens) 		PF01082
(Cu2_monooxygen)
PF03351
(DOMON)
PF03712
(Cu2_monoox_C) 		3 ASN A  97
ASP A 158
GLN A 128
 None
 0.83A 3eeyD-4zelA:
undetectable		 3eeyD-4zelA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a01 O-GLYCOSYLTRANSFERAS
E

(Drosophila
melanogaster) 		PF13374
(TPR_10)
PF13414
(TPR_11)
PF13844
(Glyco_transf_41) 		3 ASN A 948
ASP A 874
GLN A 876
 None
 0.68A 3eeyD-5a01A:
3.7		 3eeyD-5a01A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao5 C-TYPE MANNOSE
RECEPTOR 2

(Homo sapiens) 		PF00040
(fn2)
PF00059
(Lectin_C) 		3 ASN A 497
ASP A 480
GLN A 450
 None
 0.80A 3eeyD-5ao5A:
undetectable		 3eeyD-5ao5A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awn HEAVY CHAIN OF
3BC176 FAB
LIGHT CHAIN OF
3BC176 FAB

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 ASN L 128
ASP H 144
GLN H 171
 None
 0.82A 3eeyD-5awnL:
undetectable		 3eeyD-5awnL:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu1 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		3 ASN A 355
ASP A 351
GLN A 350
 None
 0.68A 3eeyD-5bu1A:
undetectable		 3eeyD-5bu1A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu2 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		3 ASN A 355
ASP A 351
GLN A 350
 None
 0.81A 3eeyD-5bu2A:
undetectable		 3eeyD-5bu2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqs ELONGATION FACTOR
1-GAMMA
ELONGATION FACTOR
1-BETA

(Homo sapiens;
Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N)
no annotation 		3 ASN A 186
ASP D  17
GLN D  13
 None
 0.81A 3eeyD-5dqsA:
undetectable		 3eeyD-5dqsA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		3 ASN A  86
ASP A  82
GLN A  78
 None
 0.78A 3eeyD-5fv4A:
undetectable		 3eeyD-5fv4A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hbt FAB35, HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASN D  60
ASP D  89
GLN D  86
 None
 0.70A 3eeyD-5hbtD:
undetectable		 3eeyD-5hbtD:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hci GPN-LOOP GTPASE 1

(Saccharomyces
cerevisiae) 		PF03029
(ATP_bind_1) 		3 ASN A 144
ASP A 200
GLN A 201
 None
 0.80A 3eeyD-5hciA:
undetectable		 3eeyD-5hciA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho9 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		3 ASN A 333
ASP A 348
GLN A 352
 None
 0.83A 3eeyD-5ho9A:
undetectable		 3eeyD-5ho9A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 ASN A 639
ASP A  12
GLN A   9
 None
 0.72A 3eeyD-5k3hA:
undetectable		 3eeyD-5k3hA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		3 ASN A 179
ASP A 212
GLN A 570
 None
 0.78A 3eeyD-5k9tA:
2.3		 3eeyD-5k9tA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc7 CEREBELLIN-1

(Homo sapiens) 		PF00386
(C1q) 		3 ASN A  71
ASP A  87
GLN A  88
 None
 0.82A 3eeyD-5kc7A:
undetectable		 3eeyD-5kc7A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		3 ASN A 462
ASP A 429
GLN A 425
 None
 0.78A 3eeyD-5ktkA:
7.4		 3eeyD-5ktkA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liq NICKING ENDONUCLEASE
N.BSPD6I

(Bacillus sp.
(in: Bacteria)) 		PF09491
(RE_AlwI) 		3 ASN A 347
ASP A 341
GLN A 337
 None
 0.79A 3eeyD-5liqA:
undetectable		 3eeyD-5liqA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		3 ASN A 499
ASP A 532
GLN A 531
 None
 0.74A 3eeyD-5mtzA:
undetectable		 3eeyD-5mtzA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80

(Chlamydomonas
reinhardtii) 		no annotation 3 ASN A 484
ASP A 505
GLN A 522
 GOL  A 809 (-3.8A)
None
GOL  A 810 (-2.9A)
 0.72A 3eeyD-5n4aA:
undetectable		 3eeyD-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5noi ROUNDABOUT HOMOLOG 2

(Homo sapiens) 		no annotation 3 ASN A 354
ASP A 385
GLN A 382
 None
 0.44A 3eeyD-5noiA:
undetectable		 3eeyD-5noiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D

(Cellvibrio
japonicus) 		no annotation 3 ASN A 439
ASP A 454
GLN A 456
 None
 0.73A 3eeyD-5oydA:
undetectable		 3eeyD-5oydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio rerio) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		3 ASN A 367
ASP A1359
GLN A1363
 EDO  A1422 (-4.3A)
None
None
 0.79A 3eeyD-5t03A:
undetectable		 3eeyD-5t03A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Lassa
mammarenavirus) 		PF00798
(Arena_glycoprot) 		3 ASN a 302
ASP a 317
GLN a 321
 None
 0.66A 3eeyD-5vk2a:
undetectable		 3eeyD-5vk2a:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcy GLUCANASE

(Phanerochaete
chrysosporium) 		PF01341
(Glyco_hydro_6) 		3 ASN A  85
ASP A 338
GLN A 333
 None
 0.71A 3eeyD-5xcyA:
undetectable		 3eeyD-5xcyA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 3 ASN A 828
ASP A1376
GLN A1383
 None
 0.76A 3eeyD-5yudA:
undetectable		 3eeyD-5yudA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 3 ASN A 217
ASP A 451
GLN A 440
 U  B 135 ( 3.0A)
None
None
 0.49A 3eeyD-6d6vA:
undetectable		 3eeyD-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f62 SYNAPTONEMAL COMPLEX
PROTEIN 1

(Homo sapiens) 		no annotation 3 ASN A 177
ASP A 171
GLN A 167
 None
 0.82A 3eeyD-6f62A:
undetectable		 3eeyD-6f62A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2

(Aspergillus
oryzae) 		no annotation 3 ASN A 332
ASP A 323
GLN A 319
 None
 0.74A 3eeyD-6g21A:
undetectable		 3eeyD-6g21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3

(Rattus rattus) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 ASN A  73
ASP A 161
GLN A 165
 None
 0.82A 3eeyD-6gswA:
undetectable		 3eeyD-6gswA:
21.33