SIMILAR PATTERNS OF AMINO ACIDS FOR 3EEY_C_SAMC300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1) 		PF00082
(Peptidase_S8) 		5 GLY A  14
ASN A  17
ILE A  90
GLY A  78
HIS A  75
 None
 1.14A 3eeyC-1dbiA:
2.1		 3eeyC-1dbiA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		5 ASP A 170
ILE A 160
GLY A 156
ASN A 167
LEU A 165
 None
None
None
ACY  A 510 (-4.4A)
None
 1.15A 3eeyC-1ddkA:
undetectable		 3eeyC-1ddkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyw PHOSPHOTRIESTERASE

(Brevundimonas
diminuta) 		PF02126
(PTE) 		6 ASP A 235
ILE A 228
GLY A 209
GLN A 212
LEU A 252
THR A 172
 None
 1.46A 3eeyC-1eywA:
undetectable		 3eeyC-1eywA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ght TRANSPOSON
GAMMA-DELTA
RESOLVASE

(Escherichia
coli) 		PF00239
(Resolvase) 		5 GLY A   5
ASP A  59
ILE A  93
GLY A  96
LEU A  23
 None
 1.17A 3eeyC-1ghtA:
undetectable		 3eeyC-1ghtA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		5 THR A 170
GLY A 172
ILE A 145
GLY A 144
LEU A 166
 None
 1.12A 3eeyC-1i8dA:
undetectable		 3eeyC-1i8dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdi L-RIBULOSE 5
PHOSPHATE
4-EPIMERASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		5 GLY A 146
ASN A 147
ILE A  93
LEU A  82
THR A  77
 None
 1.17A 3eeyC-1jdiA:
undetectable		 3eeyC-1jdiA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 GLY A  95
ASN A  96
GLY A 118
LEU A  94
THR A  59
 None
 1.14A 3eeyC-1jftA:
3.3		 3eeyC-1jftA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 GLY A  95
ASN A  96
ILE A  62
GLY A 118
LEU A  94
 None
 1.01A 3eeyC-1jftA:
3.3		 3eeyC-1jftA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqe HISTAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF13489
(Methyltransf_23) 		5 GLY A 237
ASN A 236
GLY A 263
LEU A 240
THR A 245
 None
 1.08A 3eeyC-1jqeA:
12.0		 3eeyC-1jqeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbu MURAMOYL-PENTAPEPTID
E CARBOXYPEPTIDASE

(Streptomyces
albus) 		PF01471
(PG_binding_1)
PF08291
(Peptidase_M15_3) 		5 GLY A  13
ILE A  64
GLY A  63
GLN A  54
THR A  69
 None
 1.11A 3eeyC-1lbuA:
undetectable		 3eeyC-1lbuA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		5 THR A 468
GLY A 437
ASN A 518
ILE A 459
ASN A 467
 None
CA  A 914 ( 4.0A)
None
None
None
 0.54A 3eeyC-1q5aA:
undetectable		 3eeyC-1q5aA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 GLY A 699
ASP A 719
ILE A 587
GLY A 584
HIS A 285
 None
 1.14A 3eeyC-1q8yA:
undetectable		 3eeyC-1q8yA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A  66
ASP A 116
ILE A 207
GLY A 208
ASN A 158
 None
 0.85A 3eeyC-1r3nA:
undetectable		 3eeyC-1r3nA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 GLY A 271
ASN A 270
ILE A 171
GLY A 167
THR A 280
 175  A 211 ( 4.6A)
175  A 211 ( 4.0A)
None
None
None
 1.15A 3eeyC-1t6pA:
undetectable		 3eeyC-1t6pA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		5 GLY A 119
ASP A 144
ILE A 116
GLY A 115
LEU A  96
 None
 0.95A 3eeyC-1v4vA:
4.0		 3eeyC-1v4vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE

(Thermotoga
maritima) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 GLY A 362
ILE A 400
GLY A 402
LEU A 392
THR A 357
 None
 1.12A 3eeyC-2b8nA:
4.1		 3eeyC-2b8nA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 GLY A 214
ASN A 213
GLY A  81
GLN A  43
ASN A 220
 None
 0.92A 3eeyC-2eb5A:
undetectable		 3eeyC-2eb5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		5 THR A 259
ASP A 256
ASN A 186
LEU A 264
THR A 314
 None
 1.07A 3eeyC-2i7xA:
2.1		 3eeyC-2i7xA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLY A 196
ASN A  27
ILE A 211
GLY A 145
HIS A 119
 None
None
None
None
ZN  A 561 ( 3.1A)
 0.85A 3eeyC-2it4A:
undetectable		 3eeyC-2it4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kc2 TALIN-1

(Mus musculus) 		PF09379
(FERM_N) 		5 THR A 114
ASP A 110
ILE A 119
GLY A 120
LEU A  88
 None
 1.13A 3eeyC-2kc2A:
undetectable		 3eeyC-2kc2A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3b NUCLEASE

(Nostoc sp. PCC
7120) 		PF01223
(Endonuclease_NS) 		5 THR A  75
GLY A 123
GLN A 150
ASN A  70
LEU A  67
 None
MG  A 303 ( 4.6A)
MG  A 303 ( 4.9A)
None
None
 1.08A 3eeyC-2o3bA:
undetectable		 3eeyC-2o3bA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ory LIPASE

(Photobacterium
sp. M37) 		PF01764
(Lipase_3) 		5 THR A 210
GLY A 212
ASN A 213
GLY A 177
ASN A 243
 None
 1.15A 3eeyC-2oryA:
undetectable		 3eeyC-2oryA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q42 PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 2

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 THR A 113
GLY A 111
GLY A 130
HIS A  54
LEU A 141
 None
None
None
ZN  A 700 (-3.2A)
None
 1.14A 3eeyC-2q42A:
undetectable		 3eeyC-2q42A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 THR A 111
GLY A 109
GLY A 126
HIS A  53
LEU A 137
 None
None
None
FE  A 253 (-3.3A)
None
 1.10A 3eeyC-2qedA:
undetectable		 3eeyC-2qedA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqs AGGLUTININ RECEPTOR

(Streptococcus
gordonii) 		PF16364
(Antigen_C) 		5 ASN A1319
ILE A1386
GLY A1313
ASN A1284
THR A1413
 None
 0.98A 3eeyC-2wqsA:
undetectable		 3eeyC-2wqsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 GLY A 225
ASP A 289
ILE A 212
GLY A 213
THR A 218
 None
 0.99A 3eeyC-2x3kA:
undetectable		 3eeyC-2x3kA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		6 THR A 435
ASP A 437
GLY A 380
ASN A 436
LEU A 328
THR A  92
 None
 1.18A 3eeyC-2xijA:
undetectable		 3eeyC-2xijA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		5 THR A 220
GLY A 222
ASP A 193
GLY A 273
ASN A 192
 AMP  A 502 (-3.4A)
AMP  A 502 (-3.5A)
None
None
None
 0.90A 3eeyC-3b1rA:
3.2		 3eeyC-3b1rA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt6 INFLUENZA B
HEMAGGLUTININ (HA)

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		5 THR B  25
GLY B  23
ILE B 152
LEU B 118
THR B 140
 None
 1.07A 3eeyC-3bt6B:
undetectable		 3eeyC-3bt6B:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdx SUCCINYLGLUTAMATEDES
UCCINYLASE/ASPARTOAC
YLASE

(Rhodobacter
sphaeroides) 		PF04952
(AstE_AspA) 		5 THR A 157
GLY A 215
ILE A 227
GLN A 250
THR A 257
 None
 1.12A 3eeyC-3cdxA:
undetectable		 3eeyC-3cdxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dci ARYLESTERASE

(Agrobacterium
fabrum) 		PF13472
(Lipase_GDSL_2) 		5 GLY A  50
ASP A  91
LEU A  48
THR A  12
THR A 193
 ACY  A 220 (-3.7A)
None
None
None
None
 1.06A 3eeyC-3dciA:
2.8		 3eeyC-3dciA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 THR A 424
ASP A 393
ILE A 419
GLY A 420
LEU A 431
 None
 1.16A 3eeyC-3dmyA:
2.6		 3eeyC-3dmyA:
15.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		6 ASN A  60
ILE A  53
GLY A  80
GLN A  82
LEU A 102
THR A 115
 None
SAM  A 300 (-4.0A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
SAM  A 300 ( 3.8A)
SAM  A 300 ( 4.3A)
 1.32A 3eeyC-3eeyA:
36.2		 3eeyC-3eeyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		12 THR A  28
GLY A  30
ASN A  31
ASP A  34
ILE A  53
GLY A  80
HIS A  81
GLN A  82
ASN A  98
LEU A 102
THR A 111
THR A 115
 SAM  A 300 (-4.1A)
SAM  A 300 (-3.4A)
SAM  A 300 (-4.7A)
SAM  A 300 (-3.9A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.5A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 3.8A)
SAM  A 300 (-4.4A)
SAM  A 300 ( 4.3A)
 0.08A 3eeyC-3eeyA:
36.2		 3eeyC-3eeyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbq CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13786
(DUF4179) 		5 THR A 105
ASP A  50
GLY A  83
HIS A 107
LEU A  76
 None
 1.10A 3eeyC-3fbqA:
undetectable		 3eeyC-3fbqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h41 NLP/P60 FAMILY
PROTEIN

(Bacillus cereus) 		PF00877
(NLPC_P60) 		5 ILE A 227
GLY A 230
GLN A  85
LEU A  74
THR A  39
 None
 0.64A 3eeyC-3h41A:
undetectable		 3eeyC-3h41A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE

(Streptomyces
coelicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 122
ASP A 124
ILE A  58
GLY A 402
ASN A  83
 None
 1.15A 3eeyC-3krtA:
5.6		 3eeyC-3krtA:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lby PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1697C

(Streptococcus
mutans) 		PF06962
(rRNA_methylase) 		11 THR A  27
GLY A  29
ASN A  30
ASP A  33
GLY A  75
HIS A  76
GLN A  77
ASN A  93
LEU A  97
THR A 106
THR A 110
 SAH  A4630 (-4.2A)
SAH  A4630 (-3.6A)
None
None
SAH  A4630 (-3.3A)
SAH  A4630 (-3.1A)
SAH  A4630 (-3.8A)
None
SAH  A4630 (-3.9A)
SAH  A4630 (-4.5A)
SAH  A4630 ( 4.1A)
 0.55A 3eeyC-3lbyA:
30.6		 3eeyC-3lbyA:
44.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcz O-METHYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 THR A 189
ILE A 205
GLY A 185
LEU A 224
THR A 211
 None
 1.16A 3eeyC-3mczA:
13.1		 3eeyC-3mczA:
18.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		6 THR A  27
GLY A  29
ASN A  30
GLY A  75
HIS A  76
THR A 110
 None
 0.89A 3eeyC-3mtiA:
27.1		 3eeyC-3mtiA:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		7 THR A  27
GLY A  29
ASP A  33
GLY A  75
HIS A  76
ASN A  93
THR A 110
 None
 0.53A 3eeyC-3mtiA:
27.1		 3eeyC-3mtiA:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 5 THR A 216
GLY A 198
ASN A 178
ASP A 196
GLY A 257
 None
CA  A 409 (-4.2A)
None
None
CA  A 412 (-4.3A)
 1.16A 3eeyC-3p4gA:
undetectable		 3eeyC-3p4gA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 ASN A 695
ILE A 519
GLY A 518
ASN A 688
THR A 676
 None
 1.14A 3eeyC-3psfA:
undetectable		 3eeyC-3psfA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 GLY A 744
ASP A 256
ILE A 741
GLY A 740
HIS A 260
 None
 1.14A 3eeyC-3qr1A:
undetectable		 3eeyC-3qr1A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Mycobacteroides
abscessus) 		PF00106
(adh_short) 		5 THR A  59
GLY A  15
ASP A  55
ILE A  34
THR A  66
 None
 1.10A 3eeyC-3s55A:
8.5		 3eeyC-3s55A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5c LINA

(uncultured
organism) 		no annotation 5 GLY B 131
ASN B 130
ILE B 109
HIS B  73
THR B  71
 None
 1.11A 3eeyC-3s5cB:
undetectable		 3eeyC-3s5cB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubr CYTOCHROME C-552

(Shewanella
oneidensis) 		PF02335
(Cytochrom_C552) 		5 THR A 154
GLY A 156
ASP A 126
GLY A  90
ASN A 153
 None
HEC  A 472 (-4.0A)
None
HEC  A 473 ( 4.4A)
None
 1.09A 3eeyC-3ubrA:
undetectable		 3eeyC-3ubrA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voh CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		5 THR A 290
GLY A 254
GLY A 287
ASN A 291
LEU A 259
 None
 1.11A 3eeyC-3vohA:
undetectable		 3eeyC-3vohA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 GLY A  19
ASN A  20
GLY A  15
HIS A  11
LEU A  34
 None
 1.11A 3eeyC-4anjA:
undetectable		 3eeyC-4anjA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au0 EXOGLUCANASE 2

(Trichoderma
reesei) 		PF01341
(Glyco_hydro_6) 		5 THR A 301
GLY A 265
GLY A 298
ASN A 302
LEU A 270
 None
 1.15A 3eeyC-4au0A:
undetectable		 3eeyC-4au0A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		6 GLY A 248
ASN A 567
ILE A 288
ASN A 548
LEU A 249
THR A 351
 None
NAG  A2001 (-1.9A)
None
None
NAG  A2001 (-4.9A)
None
 1.47A 3eeyC-4b56A:
undetectable		 3eeyC-4b56A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 ASN A 527
ASP A 525
GLY A 505
LEU A 459
THR A 473
 None
 1.14A 3eeyC-4byfA:
undetectable		 3eeyC-4byfA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4clc UPF0303 PROTEIN
YBR137W

(Saccharomyces
cerevisiae) 		PF03928
(Haem_degrading) 		5 ILE E  46
GLY E  43
ASN E  84
LEU E 151
THR E 147
 None
 1.14A 3eeyC-4clcE:
undetectable		 3eeyC-4clcE:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw5 DFNA

(Bacillus
velezensis) 		PF03060
(NMO) 		5 THR A 356
GLY A 358
ILE A 361
GLY A 365
ASN A 384
 None
None
None
None
FMN  A1753 (-2.8A)
 1.06A 3eeyC-4cw5A:
undetectable		 3eeyC-4cw5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		5 THR A  37
GLY A 262
ASN A 263
ILE A 256
GLY A 253
 None
 1.17A 3eeyC-4djiA:
undetectable		 3eeyC-4djiA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		5 ASP A 157
ILE A  23
GLY A  27
ASN A 155
LEU A  14
 None
 1.15A 3eeyC-4jhiA:
undetectable		 3eeyC-4jhiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii) 		PF00398
(RrnaAD) 		5 ASN A  45
ILE A  49
GLY A  50
ASN A  92
THR A  73
 None
 0.81A 3eeyC-4jxjA:
12.2		 3eeyC-4jxjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 GLY A 253
ASP A 377
ILE A 283
GLY A 281
LEU A 407
 None
None
NK  A 501 (-4.4A)
None
None
 1.13A 3eeyC-4jz6A:
4.1		 3eeyC-4jz6A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 GLY A 253
ASP A 377
ILE A 283
GLY A 281
THR A 437
 None
None
NK  A 501 (-4.4A)
None
None
 1.08A 3eeyC-4jz6A:
4.1		 3eeyC-4jz6A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt7 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Anaerococcus
prevotii) 		PF01128
(IspD) 		5 THR A  89
GLY A  92
ILE A  11
THR A 105
THR A 164
 None
 1.17A 3eeyC-4kt7A:
undetectable		 3eeyC-4kt7A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht GENERAL SECRETORY
PATHWAY PROTEIN E

(Vibrio
vulnificus) 		PF00437
(T2SSE) 		5 ASP A 154
ILE A 440
GLY A 478
THR A 438
THR A 487
 None
 1.12A 3eeyC-4phtA:
2.7		 3eeyC-4phtA:
16.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4poo PUTATIVE RNA
METHYLASE

(Bacillus
subtilis) 		PF06962
(rRNA_methylase) 		9 THR A  28
GLY A  30
ASN A  31
ASP A  34
ILE A  53
HIS A  80
ASN A 101
LEU A 105
THR A 114
 SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
 0.35A 3eeyC-4pooA:
30.1		 3eeyC-4pooA:
44.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 THR A 223
GLY A 225
ASP A 196
GLY A 280
ASN A 195
 None
 1.05A 3eeyC-4pvvA:
4.2		 3eeyC-4pvvA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi3 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF16010
(CDH-cyt) 		5 THR A  19
ASN A   3
GLY A  53
ASN A   6
THR A  34
 None
PCA  A   1 ( 4.5A)
None
None
None
 1.04A 3eeyC-4qi3A:
undetectable		 3eeyC-4qi3A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY

(Trichormus
variabilis) 		PF13458
(Peripla_BP_6) 		5 GLY A 255
ASP A 202
ILE A 252
LEU A 282
THR A 215
 None
PRO  A 501 ( 4.8A)
None
None
None
 1.15A 3eeyC-4rdcA:
4.2		 3eeyC-4rdcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 5 GLY B 188
ASN B 155
ILE B 424
GLY B 423
ASN B 270
 None
 1.09A 3eeyC-4tqoB:
undetectable		 3eeyC-4tqoB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx1 ESTERASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		5 GLY A  50
ASP A  91
LEU A  48
THR A  12
THR A 196
 None
 1.11A 3eeyC-4tx1A:
4.3		 3eeyC-4tx1A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A  20
ASN A  44
GLY A 130
ASN A  25
THR A 133
 PO4  A 401 (-3.3A)
PO4  A 401 ( 4.2A)
None
None
None
 1.10A 3eeyC-4u39A:
4.3		 3eeyC-4u39A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 GLY E 237
ASP E 233
GLY E 241
GLN E 145
ASN E 171
 None
 1.14A 3eeyC-4v1dE:
undetectable		 3eeyC-4v1dE:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 GLY A 442
ILE A 520
GLY A 522
HIS A 521
THR A 511
 EDO  A 706 ( 4.5A)
None
None
None
None
 1.16A 3eeyC-4wd1A:
5.0		 3eeyC-4wd1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT
PUTATIVE
OXIDOREDUCTASE
IRON-SULFUR SUBUNIT

(Sulfurisphaera
tokodaii;
Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF00111
(Fer2)
PF01799
(Fer2_2) 		5 GLY C  53
ILE C 136
GLY C 135
ASN C  51
THR A 643
 FES  C 201 (-3.9A)
None
None
FAD  B 301 ( 4.2A)
None
 1.07A 3eeyC-4zohC:
undetectable		 3eeyC-4zohC:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ASP A 320
GLY A 162
HIS A 161
ASN A 192
THR A 265
 None
 0.99A 3eeyC-5a05A:
3.0		 3eeyC-5a05A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo sapiens) 		PF12851
(Tet_JBP) 		5 GLY A1282
GLY A1256
ASN A1890
THR A1249
THR A1251
 None
 1.15A 3eeyC-5deuA:
undetectable		 3eeyC-5deuA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 THR A 635
GLY A 668
ASN A 669
ASP A 637
GLY A 632
 None
 1.13A 3eeyC-5dkxA:
undetectable		 3eeyC-5dkxA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		6 THR A 100
ILE A 114
GLY A 115
HIS A 116
ASN A 135
LEU A 105
 None
 1.49A 3eeyC-5dldA:
4.1		 3eeyC-5dldA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium) 		PF00497
(SBP_bac_3) 		5 GLY A 206
GLY A 132
LEU A  53
THR A 111
THR A 113
 None
None
None
GGL  A 301 (-3.9A)
GGL  A 301 (-4.0A)
 1.03A 3eeyC-5eyfA:
undetectable		 3eeyC-5eyfA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		5 GLY M  42
ILE M 173
GLY M 169
LEU M  43
THR M 216
 None
 1.15A 3eeyC-5fmgM:
undetectable		 3eeyC-5fmgM:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		6 GLY A 195
ASN A 512
ILE A 235
ASN A 493
LEU A 196
THR A 298
 None
NAG  A 912 (-1.9A)
None
None
None
None
 1.40A 3eeyC-5gz4A:
2.0		 3eeyC-5gz4A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5haf DEUBIQUITINASE SSEL

(Salmonella
enterica) 		no annotation 5 THR A 220
GLY A 186
HIS A 223
GLN A 278
THR A 243
 None
 1.09A 3eeyC-5hafA:
undetectable		 3eeyC-5hafA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hos CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		6 GLY A 134
ILE A 205
GLY A 246
ASN A 137
LEU A 135
THR A 175
 None
 1.50A 3eeyC-5hosA:
undetectable		 3eeyC-5hosA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASP A 125
ILE A 143
ASN A 124
LEU A 243
THR A 236
 None
 1.05A 3eeyC-5j0aA:
undetectable		 3eeyC-5j0aA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1b CELL WALL ASSEMBLY
REGULATOR SMI1

(Saccharomyces
cerevisiae) 		PF09346
(SMI1_KNR4) 		5 ASP A 144
ILE A 249
GLY A 250
LEU A 158
THR A 242
 None
 1.12A 3eeyC-5j1bA:
undetectable		 3eeyC-5j1bA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j60 THIOREDOXIN
REDUCTASE

(Gloeobacter
violaceus) 		PF07992
(Pyr_redox_2) 		5 ASP A 314
ILE A  10
GLY A  17
LEU A  29
THR A  77
 None
 1.08A 3eeyC-5j60A:
2.4		 3eeyC-5j60A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ke1 OUTER MEMBRANE
PROTEIN ICSA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF03212
(Pertactin)
PF12951
(PATR) 		5 THR A 661
GLY A 651
ASN A 625
GLY A 655
THR A 688
 None
 0.92A 3eeyC-5ke1A:
undetectable		 3eeyC-5ke1A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]

(Ruminococcus
flavefaciens) 		no annotation 5 THR B 102
ASN B  72
ASP B  74
GLY B  99
ASN B  78
 None
None
CA  B 201 (-3.1A)
None
None
 1.15A 3eeyC-5m2sB:
undetectable		 3eeyC-5m2sB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A 121
ILE A  88
GLY A  87
ASN A 138
LEU A 119
 None
 1.17A 3eeyC-5n9xA:
3.0		 3eeyC-5n9xA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-8

(Caenorhabditis
elegans) 		PF10220
(Smg8_Smg9) 		5 GLY E  64
ASP E   2
ILE E  41
GLY E  38
LEU E  73
 None
 1.09A 3eeyC-5nkmE:
undetectable		 3eeyC-5nkmE:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nm7 PEPTIDOGLYCAN-BINDIN
G DOMAIN 1

(Burkholderia) 		no annotation 5 GLY G   8
ILE G  56
GLY G  55
GLN G  46
THR G  61
 None
GLY  G 301 (-4.5A)
None
GLY  G 301 (-4.4A)
GLY  G 301 (-3.7A)
 1.17A 3eeyC-5nm7G:
undetectable		 3eeyC-5nm7G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 5 GLY A 558
ILE A 538
GLY A 536
LEU A 561
THR A 277
 None
None
GOL  A 605 ( 3.6A)
None
None
 1.14A 3eeyC-5oc1A:
3.1		 3eeyC-5oc1A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 169
ASP A 165
ILE A 123
GLY A 126
THR A 558
 None
 1.00A 3eeyC-5tf0A:
3.2		 3eeyC-5tf0A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubu PUTATIVE
ACETAMIDASE/FORMAMID
ASE

(Yersinia
enterocolitica) 		PF03069
(FmdA_AmdA) 		5 GLY A 188
ASP A 185
GLY A 319
ASN A 186
LEU A 204
 None
 0.99A 3eeyC-5ubuA:
undetectable		 3eeyC-5ubuA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		5 GLY A 124
ASN A 122
GLY A 193
GLN A 411
THR A 131
 None
 1.11A 3eeyC-5uj6A:
undetectable		 3eeyC-5uj6A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xs7 HEAVY CHAIN OF FAB
1D5

(Mus musculus) 		PF07686
(V-set) 		5 THR H 123
GLY H   9
LEU H  19
THR H  99
THR H  45
 None
 1.06A 3eeyC-5xs7H:
undetectable		 3eeyC-5xs7H:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ASN A 468
ASP A 534
ILE A 421
LEU A 496
THR A 546
 None
 1.16A 3eeyC-5xxoA:
2.9		 3eeyC-5xxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1

(Saccharomyces
cerevisiae) 		no annotation 5 GLY A 481
ILE A 456
GLY A 285
LEU A 482
THR A 325
 None
ATP  A 801 ( 4.4A)
ATP  A 801 ( 4.2A)
None
ATP  A 801 (-4.3A)
 1.15A 3eeyC-6az0A:
2.2		 3eeyC-6az0A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		no annotation 5 ASP A 108
ILE A  49
ASN A 109
LEU A 104
THR A  40
 MG  A 302 ( 2.5A)
None
DAU  A 301 (-3.2A)
None
None
 0.98A 3eeyC-6b5eA:
undetectable		 3eeyC-6b5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 5 GLY A 215
ASN A 533
ASN A 514
LEU A 216
THR A 318
 None
NAG  A 912 (-1.8A)
None
NAG  A 912 (-4.5A)
None
 1.08A 3eeyC-6c01A:
undetectable		 3eeyC-6c01A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis) 		no annotation 5 ASP A 220
ILE A 214
GLY A 243
HIS A 241
LEU A 255
 None
 1.16A 3eeyC-6co7A:
2.9		 3eeyC-6co7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6de8 BIFUNCTIONAL PROTEIN
FOLD

(Campylobacter
jejuni) 		no annotation 5 THR A 265
ASN A 272
GLY A   6
LEU A 142
THR A 255
 None
 0.95A 3eeyC-6de8A:
4.1		 3eeyC-6de8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 6 GLY A 216
ASN A 533
ILE A 256
ASN A 514
LEU A 217
THR A 319
 None
NAG  A1010 (-1.9A)
None
None
None
None
 1.40A 3eeyC-6f2tA:
undetectable		 3eeyC-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Rattus
norvegicus) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 ASN A  73
ASP A 161
GLN A 165
 None
 0.82A 3eeyC-1b4pA:
undetectable		 3eeyC-1b4pA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmz PROTEIN (GAIP
(G-ALPHA
INTERACTING)
PROTEIN)

(Homo sapiens) 		PF00615
(RGS) 		3 ASN A 166
ASP A 179
GLN A 183
 None
 0.80A 3eeyC-1cmzA:
undetectable		 3eeyC-1cmzA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f59 IMPORTIN BETA-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 ASN A  63
ASP A 160
GLN A 159
 None
 0.72A 3eeyC-1f59A:
undetectable		 3eeyC-1f59A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fig IGG1-KAPPA 1F7 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASN H  60
ASP H  86
GLN H  83
 None
 0.83A 3eeyC-1figH:
undetectable		 3eeyC-1figH:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq8 PECTINESTERASE

(Daucus carota) 		PF01095
(Pectinesterase) 		3 ASN A 183
ASP A 136
GLN A 113
 None
CAC  A 501 (-3.2A)
CAC  A 501 ( 4.8A)
 0.82A 3eeyC-1gq8A:
undetectable		 3eeyC-1gq8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		3 ASN P 334
ASP P 397
GLN P 393
 None
CA  P 501 (-2.6A)
CA  P 501 (-3.6A)
 0.74A 3eeyC-1h71P:
undetectable		 3eeyC-1h71P:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7k CATALASE

(Proteus
mirabilis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ASN A 223
ASP A 178
GLN A 174
 None
 0.73A 3eeyC-1h7kA:
undetectable		 3eeyC-1h7kA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		3 ASN A 152
ASP A  31
GLN A  30
 None
 0.75A 3eeyC-1i2oA:
undetectable		 3eeyC-1i2oA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr9 PROTEIN YCGM

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		3 ASN A   6
ASP A  53
GLN A  56
 None
 0.79A 3eeyC-1nr9A:
undetectable		 3eeyC-1nr9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT
QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
9 KDA SUBUNIT

(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII)
PF08992
(QH-AmDH_gamma) 		3 ASN C  56
ASP C  49
GLN A 129
 None
 0.73A 3eeyC-1pbyC:
undetectable		 3eeyC-1pbyC:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 ASN A  63
ASP A 160
GLN A 159
 None
 0.83A 3eeyC-1qgrA:
undetectable		 3eeyC-1qgrA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		3 ASN A  24
ASP A  55
GLN A  51
 None
 0.72A 3eeyC-1vf8A:
undetectable		 3eeyC-1vf8A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ASN A 375
ASP A 208
GLN A 424
 None
 0.76A 3eeyC-2b24A:
undetectable		 3eeyC-2b24A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cde INKT-TCR

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 ASN A  59
ASP A  84
GLN A  81
 None
 0.68A 3eeyC-2cdeA:
undetectable		 3eeyC-2cdeA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1

(Salmonella
enterica) 		no annotation 3 ASN A 158
ASP A 152
GLN A 148
 None
 0.77A 3eeyC-2d4yA:
undetectable		 3eeyC-2d4yA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb6 CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02635
(DrsE) 		3 ASN A  15
ASP A  54
GLN A  56
 None
 0.78A 3eeyC-2fb6A:
undetectable		 3eeyC-2fb6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		3 ASN A 230
ASP A 301
GLN A  15
 None
None
MLR  A2913 ( 3.9A)
 0.79A 3eeyC-2fncA:
undetectable		 3eeyC-2fncA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0t CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		3 ASN A  87
ASP A 210
GLN A 241
 None
None
EDO  A 341 (-3.1A)
 0.84A 3eeyC-2g0tA:
4.8		 3eeyC-2g0tA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		3 ASN A 199
ASP A 163
GLN A  28
 None
 0.78A 3eeyC-2gjxA:
undetectable		 3eeyC-2gjxA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens;
Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2)
no annotation 		3 ASN I 199
ASP I 163
GLN A  28
 None
 0.83A 3eeyC-2gk1I:
undetectable		 3eeyC-2gk1I:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 ASN A 176
ASP A 212
GLN A 677
 None
 0.79A 3eeyC-2ipcA:
2.5		 3eeyC-2ipcA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE

(Escherichia
coli) 		PF01204
(Trehalase) 		3 ASN A  69
ASP A  78
GLN A  82
 None
 0.68A 3eeyC-2jf4A:
undetectable		 3eeyC-2jf4A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 ASN A 212
ASP A 460
GLN A 412
 None
 0.83A 3eeyC-2okjA:
4.0		 3eeyC-2okjA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN

(Rattus
norvegicus) 		PF00012
(HSP70) 		3 ASN A 168
ASP A 160
GLN A 156
 None
 0.78A 3eeyC-2v7zA:
undetectable		 3eeyC-2v7zA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 ASN A 260
ASP A 538
GLN A 541
 None
 0.44A 3eeyC-2xn1A:
undetectable		 3eeyC-2xn1A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 ASN X  92
ASP X  83
GLN X  79
 None
 0.73A 3eeyC-2zkmX:
3.4		 3eeyC-2zkmX:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 3 ASN A 308
ASP A 258
GLN A 235
 None
 0.77A 3eeyC-3a0fA:
undetectable		 3eeyC-3a0fA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxz PREPROTEIN
TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF07517
(SecA_DEAD) 		3 ASN A 179
ASP A 212
GLN A 570
 None
 0.80A 3eeyC-3bxzA:
2.8		 3eeyC-3bxzA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A A SUBUNIT

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		3 ASN A 535
ASP A 570
GLN A 571
 None
 0.66A 3eeyC-3c5wA:
undetectable		 3eeyC-3c5wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgg SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		3 ASN A  24
ASP A  86
GLN A  85
 None
 0.64A 3eeyC-3cggA:
14.2		 3eeyC-3cggA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbo UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF02604
(PhdYeFM_antitox)
PF01850
(PIN) 		3 ASN A  76
ASP B 133
GLN B 132
 None
 0.73A 3eeyC-3dboA:
undetectable		 3eeyC-3dboA:
19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		3 ASN A  33
ASP A  52
GLN A  54
 SAM  A 300 (-4.0A)
SAM  A 300 (-2.9A)
SAM  A 300 (-3.8A)
 0.03A 3eeyC-3eeyA:
36.2		 3eeyC-3eeyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtu GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 ASN B  77
ASP B 165
GLN B 169
 None
 0.83A 3eeyC-3gtuB:
undetectable		 3eeyC-3gtuB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 ASN B 191
ASP B 454
GLN B 455
 None
 0.82A 3eeyC-3h0gB:
undetectable		 3eeyC-3h0gB:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		3 ASN P 349
ASP P 412
GLN P 408
 None
CA  P 485 (-2.7A)
CA  P 485 (-3.5A)
 0.78A 3eeyC-3hbuP:
undetectable		 3eeyC-3hbuP:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		3 ASN A  99
ASP A 217
GLN A 182
 LLP  A 243 ( 3.3A)
LLP  A 243 ( 2.9A)
LLP  A 243 ( 4.0A)
 0.81A 3eeyC-3hvyA:
5.6		 3eeyC-3hvyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP6

(Saccharomyces
cerevisiae) 		PF01918
(Alba) 		3 ASN A 105
ASP A 144
GLN A  77
 None
 0.78A 3eeyC-3iabA:
5.2		 3eeyC-3iabA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum) 		PF13458
(Peripla_BP_6) 		3 ASN A  78
ASP A 121
GLN A 124
 None
 0.79A 3eeyC-3ipcA:
2.1		 3eeyC-3ipcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 ASN A 480
ASP A 446
GLN A 445
 U  C  36 ( 3.4A)
A  C  35 ( 4.0A)
C  C  65 ( 4.6A)
 0.81A 3eeyC-3jb9A:
undetectable		 3eeyC-3jb9A:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN

(Rhodobacter
sphaeroides) 		PF02126
(PTE) 		3 ASN A  77
ASP A 270
GLN A 271
 None
None
DTV  A 402 ( 4.0A)
 0.72A 3eeyC-3k2gA:
undetectable		 3eeyC-3k2gA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lby PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1697C

(Streptococcus
mutans) 		PF06962
(rRNA_methylase) 		3 ASN A  32
ASP A  48
GLN A  50
 None
SAH  A4630 (-2.9A)
SAH  A4630 (-3.8A)
 0.34A 3eeyC-3lbyA:
30.6		 3eeyC-3lbyA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mti RRNA METHYLASE

(Streptococcus
thermophilus) 		PF06962
(rRNA_methylase) 		3 ASN A  32
ASP A  48
GLN A  50
 None
 0.31A 3eeyC-3mtiA:
27.1		 3eeyC-3mtiA:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II

(Streptococcus
suis) 		PF00155
(Aminotran_1_2) 		3 ASN A  57
ASP A 259
GLN A 263
 SO4  A 401 ( 3.0A)
None
None
 0.84A 3eeyC-3op7A:
5.2		 3eeyC-3op7A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bacillus
halodurans) 		PF00171
(Aldedh) 		3 ASN A 482
ASP A 135
GLN A 136
 None
 0.73A 3eeyC-3prlA:
3.2		 3eeyC-3prlA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1) 		PF01663
(Phosphodiest) 		3 ASN A 280
ASP A 290
GLN A 288
 None
 0.66A 3eeyC-3q3qA:
2.0		 3eeyC-3q3qA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 ASN A 143
ASP A 476
GLN A 433
 None
 0.82A 3eeyC-3s29A:
2.7		 3eeyC-3s29A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		3 ASN A 216
ASP A 201
GLN A 197
 None
 0.79A 3eeyC-3tc1A:
undetectable		 3eeyC-3tc1A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 ASN A 566
ASP A 574
GLN A 612
 None
 0.69A 3eeyC-3uszA:
2.6		 3eeyC-3uszA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		3 ASN A  99
ASP A  49
GLN A  52
 None
 0.71A 3eeyC-3vlaA:
undetectable		 3eeyC-3vlaA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE

(Aquifex
aeolicus) 		PF03841
(SelA) 		3 ASN A  81
ASP A 284
GLN A 291
 None
LLP  A 285 ( 4.3A)
None
 0.75A 3eeyC-3w1hA:
undetectable		 3eeyC-3w1hA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		3 ASN A 242
ASP A 377
GLN A 381
 None
 0.75A 3eeyC-4a5wA:
undetectable		 3eeyC-4a5wA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 ASN A 429
ASP A 353
GLN A 352
 None
 0.71A 3eeyC-4b90A:
undetectable		 3eeyC-4b90A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 ASN A 429
ASP A 353
GLN A 352
 None
 0.79A 3eeyC-4b92A:
undetectable		 3eeyC-4b92A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 ASN A 196
ASP A 154
GLN A 180
 None
 0.80A 3eeyC-4cztA:
undetectable		 3eeyC-4cztA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drt DE NOVO DESIGNED
SERINE HYDROLASE,
OR89

(synthetic
construct) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 ASN A  81
ASP A 111
GLN A 110
 None
 0.76A 3eeyC-4drtA:
undetectable		 3eeyC-4drtA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e37 CATALASE

(Pseudomonas
aeruginosa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ASN A 224
ASP A 179
GLN A 175
 None
 0.76A 3eeyC-4e37A:
undetectable		 3eeyC-4e37A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX

(Bacillus cereus) 		PF00091
(Tubulin) 		3 ASN A 202
ASP A  59
GLN A  58
 None
 0.72A 3eeyC-4ei8A:
4.8		 3eeyC-4ei8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 3 ASN A  76
ASP A 182
GLN A  49
 None
 0.68A 3eeyC-4fyeA:
undetectable		 3eeyC-4fyeA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbo E7

(Thermobifida
fusca) 		PF03067
(LPMO_10) 		3 ASN A  77
ASP A 120
GLN A 104
 IOD  A 311 (-3.5A)
None
None
 0.79A 3eeyC-4gboA:
undetectable		 3eeyC-4gboA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		3 ASN A 262
ASP A 208
GLN A 209
 None
 0.84A 3eeyC-4hnnA:
undetectable		 3eeyC-4hnnA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jin RIO-TYPE
SERINE/THREONINE-PRO
TEIN KINASE RIO1

(Archaeoglobus
fulgidus) 		PF01163
(RIO1) 		3 ASN A  62
ASP A 212
GLN A 215
 None
1L7  A 301 (-3.6A)
None
 0.72A 3eeyC-4jinA:
undetectable		 3eeyC-4jinA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)

(Streptococcus
agalactiae) 		PF10425
(SdrG_C_C) 		3 ASN A 423
ASP A 393
GLN A 397
 None
 0.52A 3eeyC-4mboA:
undetectable		 3eeyC-4mboA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		3 ASN A 305
ASP A 332
GLN A 330
 ASN  A 305 (-0.6A)
ASP  A 332 ( 0.5A)
GLN  A 330 ( 0.6A)
 0.81A 3eeyC-4mwtA:
undetectable		 3eeyC-4mwtA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN

(Sulfolobus
acidocaldarius) 		PF01266
(DAO) 		3 ASN A 294
ASP A 183
GLN A 233
 GRG  A 503 (-4.6A)
GRG  A 502 (-3.4A)
None
 0.77A 3eeyC-4opuA:
3.0		 3eeyC-4opuA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei) 		PF02608
(Bmp) 		3 ASN A 290
ASP A 314
GLN A 310
 None
 0.83A 3eeyC-4p98A:
undetectable		 3eeyC-4p98A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR

(Escherichia
coli) 		PF00392
(GntR)
PF07729
(FCD) 		3 ASN A 133
ASP A  19
GLN A  15
 None
 0.79A 3eeyC-4p9fA:
undetectable		 3eeyC-4p9fA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Verminephrobacter
eiseniae) 		PF03480
(DctP) 		3 ASN A 219
ASP A 230
GLN A 231
 EAX  A 401 (-2.8A)
None
None
 0.79A 3eeyC-4p9kA:
undetectable		 3eeyC-4p9kA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pp1 HEAVY CHAIN OF FAB
FRAGMENT OF MAB 5H8

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASN D  60
ASP D  89
GLN D  86
 None
 0.72A 3eeyC-4pp1D:
undetectable		 3eeyC-4pp1D:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q66 PROTEIN BCH1

(Saccharomyces
cerevisiae) 		no annotation 3 ASN K 716
ASP K 708
GLN K 704
 None
 0.74A 3eeyC-4q66K:
undetectable		 3eeyC-4q66K:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6i T-CELL SURFACE
GLYCOPROTEIN CD4

(Homo sapiens) 		PF00047
(ig)
PF05790
(C2-set) 		3 ASN C 137
ASP C 153
GLN C 152
 None
 0.81A 3eeyC-4q6iC:
undetectable		 3eeyC-4q6iC:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yds FLAGELLA-RELATED
PROTEIN H

(Sulfolobus
acidocaldarius) 		PF06745
(ATPase) 		3 ASN A 148
ASP A 142
GLN A 138
 None
 0.77A 3eeyC-4ydsA:
2.4		 3eeyC-4ydsA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zel DOPAMINE
BETA-HYDROXYLASE

(Homo sapiens) 		PF01082
(Cu2_monooxygen)
PF03351
(DOMON)
PF03712
(Cu2_monoox_C) 		3 ASN A  97
ASP A 158
GLN A 128
 None
 0.82A 3eeyC-4zelA:
undetectable		 3eeyC-4zelA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a01 O-GLYCOSYLTRANSFERAS
E

(Drosophila
melanogaster) 		PF13374
(TPR_10)
PF13414
(TPR_11)
PF13844
(Glyco_transf_41) 		3 ASN A 948
ASP A 874
GLN A 876
 None
 0.69A 3eeyC-5a01A:
5.2		 3eeyC-5a01A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao5 C-TYPE MANNOSE
RECEPTOR 2

(Homo sapiens) 		PF00040
(fn2)
PF00059
(Lectin_C) 		3 ASN A 497
ASP A 480
GLN A 450
 None
 0.79A 3eeyC-5ao5A:
undetectable		 3eeyC-5ao5A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awn HEAVY CHAIN OF
3BC176 FAB
LIGHT CHAIN OF
3BC176 FAB

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 ASN L 128
ASP H 144
GLN H 171
 None
 0.81A 3eeyC-5awnL:
undetectable		 3eeyC-5awnL:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu1 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		3 ASN A 355
ASP A 351
GLN A 350
 None
 0.70A 3eeyC-5bu1A:
undetectable		 3eeyC-5bu1A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu2 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		3 ASN A 355
ASP A 351
GLN A 350
 None
 0.83A 3eeyC-5bu2A:
undetectable		 3eeyC-5bu2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqs ELONGATION FACTOR
1-GAMMA
ELONGATION FACTOR
1-BETA

(Homo sapiens;
Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N)
no annotation 		3 ASN A 186
ASP D  17
GLN D  13
 None
 0.82A 3eeyC-5dqsA:
undetectable		 3eeyC-5dqsA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		3 ASN A  86
ASP A  82
GLN A  78
 None
 0.78A 3eeyC-5fv4A:
undetectable		 3eeyC-5fv4A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hbt FAB35, HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASN D  60
ASP D  89
GLN D  86
 None
 0.69A 3eeyC-5hbtD:
undetectable		 3eeyC-5hbtD:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hci GPN-LOOP GTPASE 1

(Saccharomyces
cerevisiae) 		PF03029
(ATP_bind_1) 		3 ASN A 144
ASP A 200
GLN A 201
 None
 0.81A 3eeyC-5hciA:
undetectable		 3eeyC-5hciA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF11864
(DUF3384) 		3 ASN A 366
ASP A 378
GLN A 320
 ASN  A 366 ( 0.6A)
ASP  A 378 ( 0.6A)
GLN  A 320 ( 0.6A)
 0.84A 3eeyC-5hiuA:
undetectable		 3eeyC-5hiuA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho9 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		3 ASN A 333
ASP A 348
GLN A 352
 None
 0.84A 3eeyC-5ho9A:
undetectable		 3eeyC-5ho9A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 ASN A 639
ASP A  12
GLN A   9
 None
 0.72A 3eeyC-5k3hA:
undetectable		 3eeyC-5k3hA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		3 ASN A 179
ASP A 212
GLN A 570
 None
 0.77A 3eeyC-5k9tA:
2.0		 3eeyC-5k9tA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc7 CEREBELLIN-1

(Homo sapiens) 		PF00386
(C1q) 		3 ASN A  71
ASP A  87
GLN A  88
 None
 0.81A 3eeyC-5kc7A:
undetectable		 3eeyC-5kc7A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		3 ASN A 462
ASP A 429
GLN A 425
 None
 0.77A 3eeyC-5ktkA:
7.5		 3eeyC-5ktkA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liq NICKING ENDONUCLEASE
N.BSPD6I

(Bacillus sp.
(in: Bacteria)) 		PF09491
(RE_AlwI) 		3 ASN A 347
ASP A 341
GLN A 337
 None
 0.79A 3eeyC-5liqA:
2.9		 3eeyC-5liqA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		3 ASN A 499
ASP A 532
GLN A 531
 None
 0.74A 3eeyC-5mtzA:
undetectable		 3eeyC-5mtzA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80

(Chlamydomonas
reinhardtii) 		no annotation 3 ASN A 484
ASP A 505
GLN A 522
 GOL  A 809 (-3.8A)
None
GOL  A 810 (-2.9A)
 0.73A 3eeyC-5n4aA:
undetectable		 3eeyC-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5noi ROUNDABOUT HOMOLOG 2

(Homo sapiens) 		no annotation 3 ASN A 354
ASP A 385
GLN A 382
 None
 0.43A 3eeyC-5noiA:
undetectable		 3eeyC-5noiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D

(Cellvibrio
japonicus) 		no annotation 3 ASN A 439
ASP A 454
GLN A 456
 None
 0.71A 3eeyC-5oydA:
undetectable		 3eeyC-5oydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio rerio) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		3 ASN A 367
ASP A1359
GLN A1363
 EDO  A1422 (-4.3A)
None
None
 0.78A 3eeyC-5t03A:
undetectable		 3eeyC-5t03A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Lassa
mammarenavirus) 		PF00798
(Arena_glycoprot) 		3 ASN a 302
ASP a 317
GLN a 321
 None
 0.67A 3eeyC-5vk2a:
undetectable		 3eeyC-5vk2a:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcy GLUCANASE

(Phanerochaete
chrysosporium) 		PF01341
(Glyco_hydro_6) 		3 ASN A  85
ASP A 338
GLN A 333
 None
 0.72A 3eeyC-5xcyA:
undetectable		 3eeyC-5xcyA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 3 ASN A 828
ASP A1376
GLN A1383
 None
 0.77A 3eeyC-5yudA:
undetectable		 3eeyC-5yudA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 3 ASN A 217
ASP A 451
GLN A 440
 U  B 135 ( 3.0A)
None
None
 0.50A 3eeyC-6d6vA:
undetectable		 3eeyC-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f62 SYNAPTONEMAL COMPLEX
PROTEIN 1

(Homo sapiens) 		no annotation 3 ASN A 177
ASP A 171
GLN A 167
 None
 0.82A 3eeyC-6f62A:
undetectable		 3eeyC-6f62A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2

(Aspergillus
oryzae) 		no annotation 3 ASN A 332
ASP A 323
GLN A 319
 None
 0.73A 3eeyC-6g21A:
undetectable		 3eeyC-6g21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3

(Rattus rattus) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 ASN A  73
ASP A 161
GLN A 165
 None
 0.83A 3eeyC-6gswA:
undetectable		 3eeyC-6gswA:
21.33