SIMILAR PATTERNS OF AMINO ACIDS FOR 3EEO_A_SAMA328_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dct PROTEIN
(MODIFICATION
METHYLASE HAEIII)

(Haemophilus
influenzae) 		PF00145
(DNA_methylase) 		6 PHE A   7
GLY A  11
ILE A  51
PRO A  70
LEU A  90
ASN A 306
 None
 1.18A 3eeoA-1dctA:
32.7		 3eeoA-1dctA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dct PROTEIN
(MODIFICATION
METHYLASE HAEIII)

(Haemophilus
influenzae) 		PF00145
(DNA_methylase) 		9 PHE A   7
GLY A  12
ASN A  28
ASP A  31
ASP A  50
ILE A  51
PRO A  70
LEU A  90
ASN A 306
 None
 0.90A 3eeoA-1dctA:
32.7		 3eeoA-1dctA:
33.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 PHE A 119
GLY A 179
ASP A 173
ILE A 187
TYR A 435
 None
 1.12A 3eeoA-1hp1A:
2.1		 3eeoA-1hp1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 LEU A  84
GLY A  89
ASN B 374
TYR A  91
ASN B 304
 None
 1.12A 3eeoA-1hr7A:
undetectable		 3eeoA-1hr7A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i60 IOLI PROTEIN

(Bacillus
subtilis) 		PF01261
(AP_endonuc_2) 		5 GLY A  78
ASP A 123
ILE A 139
LEU A 141
ASN A  73
 None
 1.12A 3eeoA-1i60A:
2.3		 3eeoA-1i60A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia7 CELLULASE CEL9M

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9) 		5 LEU A  74
GLY A  75
TRP A 256
ASP A 414
ASP A 257
 None
None
SO4  A1335 (-4.1A)
SO4  A1335 ( 4.3A)
EDO  A1337 ( 3.5A)
 1.16A 3eeoA-1ia7A:
undetectable		 3eeoA-1ia7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipg BEM1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00564
(PB1) 		5 PHE A  17
GLY A  59
ASP A  22
ILE A  41
LEU A  26
 None
 1.21A 3eeoA-1ipgA:
undetectable		 3eeoA-1ipgA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npc NEUTRAL PROTEASE

(Bacillus cereus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 LEU A  24
GLY A   3
TRP A  56
ASP A  58
ASP A  44
 None
None
None
CA  A 321 ( 2.2A)
None
 1.05A 3eeoA-1npcA:
undetectable		 3eeoA-1npcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzm ATP-DEPENDENT
PROTEASE LA

(Escherichia
coli) 		no annotation 5 LEU A 579
GLY A 580
ASP A 562
TYR A 535
ASN A 574
 None
 1.17A 3eeoA-1qzmA:
undetectable		 3eeoA-1qzmA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 PHE A 394
GLY A 171
ASP A 396
ILE A 393
PRO A 376
 None
 1.25A 3eeoA-1rblA:
undetectable		 3eeoA-1rblA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)

(Gallus gallus) 		PF12796
(Ank_2) 		5 ASN B 254
ASP B 257
ILE B 219
PRO B 235
LEU B 203
 None
 1.21A 3eeoA-1s70B:
undetectable		 3eeoA-1s70B:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avd CATECHOL-O-METHYLTRA
NSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		5 PHE A 179
LEU A  94
ASP A 108
ASP A 157
LEU A 170
 None
None
SAM  A 501 ( 4.7A)
None
None
 1.22A 3eeoA-2avdA:
undetectable		 3eeoA-2avdA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		5 PHE A 244
GLY A 366
ASP A 219
ILE A 209
LEU A 206
 None
 1.14A 3eeoA-2bb0A:
undetectable		 3eeoA-2bb0A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpo METHYLASE YHHF

(Escherichia
coli) 		PF03602
(Cons_hypoth95) 		5 PHE A  60
GLY A  67
ASP A  84
PRO A 129
LEU A 134
 None
None
None
None
CL  A 401 (-4.5A)
 1.00A 3eeoA-2fpoA:
9.9		 3eeoA-2fpoA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		6 LEU A  21
GLY A  23
ASP A 103
ILE A 104
TYR A 285
ASN A 304
 SAH  A 328 (-4.1A)
SAH  A 328 (-3.6A)
None
None
None
SAH  A 328 (-3.7A)
 1.40A 3eeoA-2i9kA:
54.1		 3eeoA-2i9kA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		9 PHE A  18
LEU A  21
ASN A  39
TRP A  41
ASP A  42
ASP A  60
ILE A  61
LEU A 100
TYR A 289
 SAH  A 328 (-4.9A)
SAH  A 328 (-4.1A)
SAH  A 328 (-4.3A)
SAH  A 328 (-3.4A)
None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 ( 4.9A)
None
 1.25A 3eeoA-2i9kA:
54.1		 3eeoA-2i9kA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		7 PHE A  18
LEU A  21
GLY A  22
PRO A  80
LEU A 100
TYR A 285
ASN A 304
 SAH  A 328 (-4.9A)
SAH  A 328 (-4.1A)
None
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
None
SAH  A 328 (-3.7A)
 1.08A 3eeoA-2i9kA:
54.1		 3eeoA-2i9kA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		12 PHE A  18
LEU A  21
GLY A  23
ASN A  39
TRP A  41
ASP A  42
ASP A  60
ILE A  61
PRO A  80
LEU A 100
TYR A 285
ASN A 304
 SAH  A 328 (-4.9A)
SAH  A 328 (-4.1A)
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-3.4A)
None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
None
SAH  A 328 (-3.7A)
 0.47A 3eeoA-2i9kA:
54.1		 3eeoA-2i9kA:
99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5c 1,8-CINEOLE SYNTHASE

(Salvia
fruticosa) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ASP A 345
ILE A 344
PRO A 450
LEU A 416
TYR A 329
 None
 1.05A 3eeoA-2j5cA:
undetectable		 3eeoA-2j5cA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfk BUD EMERGENCE
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00564
(PB1) 		5 PHE A  10
GLY A  52
ASP A  15
ILE A  34
LEU A  19
 None
 1.20A 3eeoA-2kfkA:
undetectable		 3eeoA-2kfkA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzb ADENOSYLCOBINAMIDE-P
HOSPHATE
GUANYLYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF12804
(NTP_transf_3) 		5 LEU A  24
GLY A  26
ILE A   5
PRO A  36
LEU A  37
 None
 1.09A 3eeoA-2mzbA:
undetectable		 3eeoA-2mzbA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		5 LEU C 236
ASN C 232
ASP C 175
TYR C 284
ASN C 255
 None
 1.21A 3eeoA-2nymC:
undetectable		 3eeoA-2nymC:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reb REC A

(Escherichia
coli) 		PF00154
(RecA) 		5 GLY A 180
ASP A 139
ILE A 190
LEU A  56
ASN A 186
 None
 1.18A 3eeoA-2rebA:
undetectable		 3eeoA-2rebA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		5 LEU A  74
GLY A  75
TRP A 260
ASP A 427
ASP A 261
 None
None
None
None
CA  A1447 (-4.4A)
 1.19A 3eeoA-2xfgA:
undetectable		 3eeoA-2xfgA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		5 GLY A 272
ASP A 293
ASP A 318
PRO A 339
LEU A 371
 SFG  A5748 (-3.7A)
None
SFG  A5748 (-3.7A)
SFG  A5748 (-4.0A)
None
 0.93A 3eeoA-2yxlA:
9.0		 3eeoA-2yxlA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 LEU A 621
GLY A 624
TRP A 611
ASP A 580
ILE A 655
 None
 1.22A 3eeoA-3ai7A:
undetectable		 3eeoA-3ai7A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE
GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
no annotation 		5 PHE E 109
LEU A 188
GLY A 189
ASP E 148
ILE E 149
 None
 1.04A 3eeoA-3aoeE:
3.8		 3eeoA-3aoeE:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 PHE A1148
GLY A1152
PRO A1228
LEU A1250
ASN A1580
 SAM  A   1 (-4.9A)
SAM  A   1 (-4.1A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.6A)
SAM  A   1 (-4.5A)
 1.01A 3eeoA-3av6A:
18.0		 3eeoA-3av6A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		6 PHE A1148
GLY A1153
ASP A1193
PRO A1228
LEU A1250
ASN A1580
 SAM  A   1 (-4.9A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.6A)
SAM  A   1 (-4.5A)
 0.75A 3eeoA-3av6A:
18.0		 3eeoA-3av6A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF14587
(Glyco_hydr_30_2) 		5 PHE A  45
LEU A  72
GLY A  85
ASP A  43
ILE A  42
 None
 1.19A 3eeoA-3clwA:
undetectable		 3eeoA-3clwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 GLY A 180
ASP A 139
ILE A 190
LEU A  56
ASN A 186
 None
 1.17A 3eeoA-3cmtA:
1.7		 3eeoA-3cmtA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 GLY A1180
ASP A1139
ILE A1190
LEU A1056
ASN A1186
 None
 1.17A 3eeoA-3cmtA:
1.7		 3eeoA-3cmtA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 GLY A2180
ASP A2139
ILE A2190
LEU A2056
ASN A2186
 None
 1.17A 3eeoA-3cmtA:
1.7		 3eeoA-3cmtA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 GLY A3180
ASP A3139
ILE A3190
LEU A3056
ASN A3186
 None
 1.18A 3eeoA-3cmtA:
1.7		 3eeoA-3cmtA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 GLY A4180
ASP A4139
ILE A4190
LEU A4056
ASN A4186
 None
 1.17A 3eeoA-3cmtA:
1.7		 3eeoA-3cmtA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 GLY A3180
ASP A3139
ILE A3190
LEU A3056
ASN A3186
 None
 1.19A 3eeoA-3cmuA:
undetectable		 3eeoA-3cmuA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 GLY A 180
ASP A 139
ILE A 190
LEU A  56
ASN A 186
 None
 1.23A 3eeoA-3cmvA:
undetectable		 3eeoA-3cmvA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		5 PHE A 698
GLY A 703
ASP A 721
ASP A 747
PRO A 765
 ADP  A   3 (-4.5A)
None
None
ADP  A   3 (-3.4A)
ADP  A   3 (-3.3A)
 0.53A 3eeoA-3egiA:
9.5		 3eeoA-3egiA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnb ACYLAMINOACYL
PEPTIDASE SMU_737

(Streptococcus
mutans) 		PF12146
(Hydrolase_4) 		5 GLY A 177
ASP A 157
ILE A 249
LEU A 217
ASN A 186
 None
 1.16A 3eeoA-3fnbA:
5.0		 3eeoA-3fnbA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		5 PHE A   7
GLY A  12
ASP A  31
ASP A  51
ASN A 347
 None
 0.85A 3eeoA-3g7uA:
20.3		 3eeoA-3g7uA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		5 PHE A   7
GLY A  12
ASP A  31
ASP A  51
PRO A  78
 None
 1.08A 3eeoA-3g7uA:
20.3		 3eeoA-3g7uA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		5 PHE A   7
GLY A  12
ASP A  31
PRO A  78
LEU A  97
 None
 1.04A 3eeoA-3g7uA:
20.3		 3eeoA-3g7uA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		5 PHE A 698
GLY A 703
ASP A 721
ASP A 747
PRO A 765
 SAH  A 854 (-4.3A)
SAH  A 854 (-3.0A)
None
SAH  A 854 (-3.6A)
SAH  A 854 (-3.8A)
 0.54A 3eeoA-3gdhA:
9.9		 3eeoA-3gdhA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT H

(Saccharomyces
cerevisiae) 		PF03224
(V-ATPase_H_N)
PF11698
(V-ATPase_H_C) 		5 LEU P 402
GLY P 446
ASP P 426
ILE P 384
LEU P 433
 None
 1.22A 3eeoA-3j9tP:
undetectable		 3eeoA-3j9tP:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 LEU A 427
GLY A 429
ILE A 686
TYR A 410
ASN A 463
 None
 0.98A 3eeoA-3la4A:
undetectable		 3eeoA-3la4A:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lx6 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		5 PHE A  93
GLY A  97
ILE A 141
PRO A 176
LEU A 205
 None
 1.01A 3eeoA-3lx6A:
24.8		 3eeoA-3lx6A:
33.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lx6 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		6 PHE A  93
GLY A  98
ASP A 140
ILE A 141
PRO A 176
LEU A 205
 None
 0.79A 3eeoA-3lx6A:
24.8		 3eeoA-3lx6A:
33.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		5 GLY A 114
ASN A 132
ASP A 135
PRO A 179
LEU A 211
 None
 0.88A 3eeoA-3m6xA:
8.7		 3eeoA-3m6xA:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		5 PHE A  93
GLY A  97
ILE A 141
LEU A 205
ASN A 436
 None
 0.95A 3eeoA-3me5A:
23.7		 3eeoA-3me5A:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		5 PHE A  93
GLY A  97
ILE A 141
PRO A 176
LEU A 205
 None
 0.98A 3eeoA-3me5A:
23.7		 3eeoA-3me5A:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		5 PHE A  93
GLY A  98
ASP A 140
ILE A 141
ASN A 436
 None
 1.09A 3eeoA-3me5A:
23.7		 3eeoA-3me5A:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		5 PHE A  93
GLY A  98
ILE A 141
LEU A 205
ASN A 436
 None
 0.69A 3eeoA-3me5A:
23.7		 3eeoA-3me5A:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		5 PHE A  93
GLY A  98
ILE A 141
PRO A 176
LEU A 205
 None
 0.64A 3eeoA-3me5A:
23.7		 3eeoA-3me5A:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o85 RIBOSOMAL PROTEIN
L7AE

(Giardia
intestinalis) 		PF01248
(Ribosomal_L7Ae) 		5 LEU A  19
ASP A   4
ILE A  60
PRO A  67
LEU A  64
 None
 1.12A 3eeoA-3o85A:
undetectable		 3eeoA-3o85A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 5 LEU A 153
GLY A 170
ASP A 179
ILE A 221
ASN A 173
 None
None
CA  A 407 ( 2.4A)
None
None
 1.23A 3eeoA-3p4gA:
undetectable		 3eeoA-3p4gA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 PHE A 304
GLY A 415
ILE A 297
PRO A 233
LEU A 296
 None
 1.23A 3eeoA-3pocA:
undetectable		 3eeoA-3pocA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		5 PHE A1145
ASP A1190
PRO A1225
LEU A1247
ASN A1578
 SAH  A1601 (-4.4A)
SAH  A1601 ( 4.7A)
SAH  A1601 (-4.2A)
SAH  A1601 (-3.7A)
SAH  A1601 (-4.2A)
 0.65A 3eeoA-3ptaA:
22.0		 3eeoA-3ptaA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		5 PHE A1145
GLY A1149
PRO A1225
LEU A1247
ASN A1578
 SAH  A1601 (-4.4A)
SAH  A1601 ( 4.8A)
SAH  A1601 (-4.2A)
SAH  A1601 (-3.7A)
SAH  A1601 (-4.2A)
 1.04A 3eeoA-3ptaA:
22.0		 3eeoA-3ptaA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		5 PHE A1145
GLY A1150
ASP A1190
PRO A1225
LEU A1247
 SAH  A1601 (-4.4A)
SAH  A1601 (-3.6A)
SAH  A1601 ( 4.7A)
SAH  A1601 (-4.2A)
SAH  A1601 (-3.7A)
 0.57A 3eeoA-3ptaA:
22.0		 3eeoA-3ptaA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		5 PHE A 170
GLY A 201
ILE A 120
PRO A 155
ASN A 173
 None
 1.14A 3eeoA-3q9cA:
undetectable		 3eeoA-3q9cA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrp PROBABLE FUMARATE
HYDRATASE FUM

(Mycobacteroides
abscessus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 GLY A 183
ASP A 458
ILE A 434
PRO A 410
LEU A 411
 None
 1.08A 3eeoA-3rrpA:
undetectable		 3eeoA-3rrpA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		5 LEU A 340
ASP A 374
ASP A 467
ILE A 402
LEU A 459
 None
CA  A 504 ( 2.5A)
None
None
None
 1.23A 3eeoA-3vi1A:
undetectable		 3eeoA-3vi1A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3von UBIQUITIN
THIOESTERASE OTUB1

(Homo sapiens) 		PF10275
(Peptidase_C65) 		5 PHE A  92
GLY A 264
ILE A 231
LEU A 223
ASN A  90
 None
 1.11A 3eeoA-3vonA:
undetectable		 3eeoA-3vonA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 5 LEU A 315
GLY A 313
ILE A 342
TYR A 311
ASN A 333
 None
 1.14A 3eeoA-3wvrA:
undetectable		 3eeoA-3wvrA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 PHE A 165
GLY A 392
ILE A 162
LEU A 219
TYR A 403
 None
 1.24A 3eeoA-4a3rA:
undetectable		 3eeoA-4a3rA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apb FUMARATE HYDRATASE
CLASS II

(Mycobacterium
tuberculosis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 GLY A 184
ASP A 459
ILE A 435
PRO A 411
LEU A 412
 None
 1.04A 3eeoA-4apbA:
undetectable		 3eeoA-4apbA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axk 1-(5-PHOSPHORIBOSYL)
-5-((5'-PHOSPHORIBOS
YLAMINO)
METHYLIDENEAMINO)IMI
DAZOLE-4-CARBOXAMIDE
ISOMERASE

(Corynebacterium
efficiens) 		PF00977
(His_biosynth) 		5 PHE A  50
GLY A  82
ILE A  69
LEU A  48
ASN A 101
 None
GOL  A1249 ( 4.3A)
None
None
None
 1.24A 3eeoA-4axkA:
2.1		 3eeoA-4axkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 PHE A 286
LEU A 279
GLY A 251
ASN A 354
ILE A 348
 None
None
None
GOL  A1562 (-4.1A)
None
 1.13A 3eeoA-4cmnA:
2.8		 3eeoA-4cmnA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Mycoplasma
penetrans) 		PF00145
(DNA_methylase) 		6 PHE A  17
GLY A  21
ILE A 114
PRO A 134
LEU A 157
ASN A 374
 SAH  A 501 (-4.8A)
SAH  A 501 (-4.0A)
SAH  A 501 (-4.3A)
SAH  A 501 ( 4.4A)
SAH  A 501 (-4.8A)
SAH  A 501 (-4.3A)
 1.01A 3eeoA-4dkjA:
33.6		 3eeoA-4dkjA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Mycoplasma
penetrans) 		PF00145
(DNA_methylase) 		7 PHE A  17
TRP A  46
ASP A 113
ILE A 114
PRO A 134
LEU A 157
ASN A 374
 SAH  A 501 (-4.8A)
SAH  A 501 (-4.0A)
SAH  A 501 (-3.7A)
SAH  A 501 (-4.3A)
SAH  A 501 ( 4.4A)
SAH  A 501 (-4.8A)
SAH  A 501 (-4.3A)
 0.72A 3eeoA-4dkjA:
33.6		 3eeoA-4dkjA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f67 UPF0176 PROTEIN
LPG2838

(Legionella
pneumophila) 		PF00581
(Rhodanese) 		5 LEU A 140
GLY A 221
ASP A 135
ILE A 147
LEU A 130
 None
 0.99A 3eeoA-4f67A:
undetectable		 3eeoA-4f67A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 GLY A 186
ASN A 203
ASP A 237
PRO A 257
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-3.5A)
SAM  A 401 (-4.0A)
None
 1.05A 3eeoA-4fzvA:
8.0		 3eeoA-4fzvA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 LEU B 427
GLY B 429
ILE B 686
TYR B 410
ASN B 463
 None
 0.95A 3eeoA-4g7eB:
undetectable		 3eeoA-4g7eB:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN

(Anaerococcus
prevotii) 		PF12710
(HAD) 		5 GLY A 234
ILE A 239
LEU A 267
TYR A  32
ASN A 308
 None
 1.09A 3eeoA-4gxtA:
undetectable		 3eeoA-4gxtA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN

(Veillonella
parvula) 		PF13354
(Beta-lactamase2) 		5 LEU A 171
GLY A 228
ASP A 246
ILE A 247
TYR A 175
 None
 1.22A 3eeoA-4hesA:
undetectable		 3eeoA-4hesA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 315
GLY A 312
TRP A 269
ASP A 288
LEU A  94
 None
 0.98A 3eeoA-4i3gA:
undetectable		 3eeoA-4i3gA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 PHE A 394
GLY A 171
ASP A 396
ILE A 393
PRO A 376
 None
 1.21A 3eeoA-4mkvA:
undetectable		 3eeoA-4mkvA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv1 FORMYLTRANSFERASE

(Francisella
tularensis) 		no annotation 5 ASN C  90
ASP C 123
ASP C 127
LEU C  77
ASN C  84
 None
 1.23A 3eeoA-4nv1C:
undetectable		 3eeoA-4nv1C:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 LEU A 681
GLY A 678
ASP A 754
ILE A 755
ASN A 614
 None
 1.22A 3eeoA-4okdA:
undetectable		 3eeoA-4okdA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onq DNA
METHYLTRANSFERASE

(Nicotiana
tabacum) 		PF00145
(DNA_methylase) 		5 PHE A 488
GLY A 493
ASP A 539
LEU A 588
ASN A 460
 SFG  A 700 (-4.5A)
SFG  A 700 (-3.6A)
SFG  A 700 ( 4.4A)
SFG  A 700 (-4.9A)
None
 0.90A 3eeoA-4onqA:
7.1		 3eeoA-4onqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s28 PHOSPHOMETHYLPYRIMID
INE SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01964
(ThiC_Rad_SAM) 		5 LEU A 482
GLY A 452
ASN A 421
ILE A 381
ASN A 226
 None
 1.21A 3eeoA-4s28A:
2.5		 3eeoA-4s28A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 PHE A1145
GLY A1149
PRO A1225
LEU A1247
ASN A1578
 SAH  A1706 (-4.8A)
SAH  A1706 ( 4.3A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.6A)
SAH  A1706 (-4.5A)
 0.95A 3eeoA-4wxxA:
18.3		 3eeoA-4wxxA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		6 PHE A1145
GLY A1150
ASP A1190
PRO A1225
LEU A1247
ASN A1578
 SAH  A1706 (-4.8A)
SAH  A1706 (-3.2A)
SAH  A1706 (-3.3A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.6A)
SAH  A1706 (-4.5A)
 0.79A 3eeoA-4wxxA:
18.3		 3eeoA-4wxxA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqb NADP-DEPENDENT
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF02826
(2-Hacid_dh_C) 		5 LEU A 148
GLY A 149
ASP A 252
ILE A 223
LEU A 111
 NAP  A 401 (-3.8A)
None
NAP  A 401 (-3.9A)
None
None
 1.11A 3eeoA-4zqbA:
4.5		 3eeoA-4zqbA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd7 MATERNAL EFFECT
PROTEIN OSKAR

(Drosophila
melanogaster) 		PF12872
(OST-HTH) 		5 PHE A 189
ASP A 157
PRO A 190
LEU A 191
ASN A 187
 None
 1.17A 3eeoA-5cd7A:
undetectable		 3eeoA-5cd7A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		5 GLY A 347
ASN A 240
ILE A 243
LEU A 247
ASN A 291
 None
 1.17A 3eeoA-5cerA:
undetectable		 3eeoA-5cerA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI

(Homo sapiens) 		PF00024
(PAN_1)
PF00089
(Trypsin) 		5 LEU A 239
GLY A 217
ASP A 185
ILE A 183
PRO A 247
 None
 1.23A 3eeoA-5eodA:
undetectable		 3eeoA-5eodA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		6 PHE A1148
GLY A1153
ASP A1193
PRO A1228
LEU A1250
ASN A1580
 SAH  A1701 (-4.8A)
SAH  A1701 (-3.3A)
SAH  A1701 (-3.7A)
SAH  A1701 ( 4.5A)
SAH  A1701 (-4.6A)
SAH  A1701 (-3.9A)
 0.87A 3eeoA-5gutA:
undetectable		 3eeoA-5gutA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7k ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 PHE A 205
GLY A 127
ASP A 154
LEU A 214
ASN A 151
 None
None
GDP  A 501 (-2.8A)
None
GDP  A 501 (-3.3A)
 1.13A 3eeoA-5h7kA:
4.3		 3eeoA-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikj CRYPTIC LOCI
REGULATOR 2
CRYPTIC LOCI
REGULATOR PROTEIN 1

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF10383
(Clr2)
PF16761
(Clr2_transil)
no annotation 		5 PHE A 342
GLY B1227
ASP A 344
ILE A 122
TYR A 225
 None
 1.18A 3eeoA-5ikjA:
undetectable		 3eeoA-5ikjA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il0 METTL3

(Homo sapiens) 		PF05063
(MT-A70) 		5 PHE A 534
ASP A 377
ILE A 378
PRO A 397
LEU A 409
 None
 0.96A 3eeoA-5il0A:
5.1		 3eeoA-5il0A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 5 LEU A 452
ASP A 546
ILE A 502
PRO A 605
LEU A 503
 None
 1.22A 3eeoA-5o7eA:
undetectable		 3eeoA-5o7eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3y TWO-COMPONENT SYSTEM
RESPONSE REGULATOR

(Burkholderia
multivorans) 		PF00072
(Response_reg) 		5 GLY A  86
ASP A  53
ILE A  65
PRO A  57
ASN A  55
 None
 1.19A 3eeoA-5t3yA:
undetectable		 3eeoA-5t3yA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT

(Homo sapiens) 		PF05063
(MT-A70) 		5 PHE A 534
ASP A 377
ILE A 378
PRO A 397
LEU A 409
 SAH  A 601 (-4.7A)
SAH  A 601 (-3.2A)
SAH  A 601 (-3.9A)
SAH  A 601 (-4.3A)
None
 0.99A 3eeoA-5teyA:
5.1		 3eeoA-5teyA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LEU A 438
GLY A 441
ILE A 476
LEU A 555
TYR A 437
 None
 1.17A 3eeoA-5uv2A:
undetectable		 3eeoA-5uv2A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ave ACID-SENSING ION
CHANNEL 1

(Gallus gallus) 		no annotation 5 PHE A 101
GLY A 163
ASP A 228
ILE A 138
PRO A 232
 None
 0.93A 3eeoA-6aveA:
undetectable		 3eeoA-6aveA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bni LYSINE--TRNA LIGASE

(Cryptosporidium
parvum) 		no annotation 5 PHE A 368
ILE A 372
PRO A 436
LEU A 414
TYR A 320
 None
 1.14A 3eeoA-6bniA:
undetectable		 3eeoA-6bniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fbk SERINE/THREONINE-PRO
TEIN KINASE WNK2
SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 PHE A 498
GLY P1255
ASP A 501
ILE A 532
LEU A 476
 None
 0.91A 3eeoA-6fbkA:
undetectable		 3eeoA-6fbkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi) 		no annotation 5 LEU A 204
GLY A 241
ASP A 207
ILE A 271
LEU A 296
 KCX  A 205 ( 3.9A)
None
MG  A 500 ( 2.7A)
None
None
 1.15A 3eeoA-6ftlA:
undetectable		 3eeoA-6ftlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-) 		no annotation 5 GLY D 479
TRP D 370
ILE D 440
LEU D 437
TYR D 423
 None
 1.15A 3eeoA-6gsaD:
undetectable		 3eeoA-6gsaD:
undetectable