SIMILAR PATTERNS OF AMINO ACIDS FOR 3E9X_A_NIMA1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		4 GLU A 659
GLY A 662
THR A 663
GLU A 664
 None
 1.28A 3e9xA-1biyA:
41.0		 3e9xA-1biyA:
91.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci3 PROTEIN (CYTOCHROME
F)

(Phormidium
laminosum) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		4 GLU M 220
GLY M 218
THR M 181
GLU M 217
 None
 1.21A 3e9xA-1ci3M:
0.0		 3e9xA-1ci3M:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g82 FIBROBLAST GROWTH
FACTOR 9

(Homo sapiens) 		PF00167
(FGF) 		4 GLU A 120
GLY A 122
THR A 176
GLU A 174
 None
 1.20A 3e9xA-1g82A:
undetectable		 3e9xA-1g82A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 GLU A 414
GLY A 416
THR A 367
GLU A 366
 None
 1.10A 3e9xA-1hp1A:
0.0		 3e9xA-1hp1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hru YRDC GENE PRODUCT

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC) 		4 GLU A  28
GLY A 170
THR A 169
GLU A 168
 None
 1.16A 3e9xA-1hruA:
undetectable		 3e9xA-1hruA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 GLU A1081
GLY A1083
THR A1085
GLU A1086
 None
 1.08A 3e9xA-1ofeA:
0.0		 3e9xA-1ofeA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		4 GLU A 150
GLY A 149
THR A 145
GLU A 148
 None
 1.15A 3e9xA-1q15A:
0.0		 3e9xA-1q15A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 GLU A  40
GLY A  18
THR A  19
GLU A  20
 None
 0.84A 3e9xA-1q8iA:
undetectable		 3e9xA-1q8iA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		4 GLU A  71
GLY A  65
THR A  95
GLU A  93
 None
 1.12A 3e9xA-1rk2A:
0.0		 3e9xA-1rk2A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		4 GLU A 167
GLY A 146
THR A 169
GLU A 148
 None
 1.16A 3e9xA-1ru4A:
undetectable		 3e9xA-1ru4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 GLU E 170
GLY E 138
THR E 137
GLU E 136
 None
 1.03A 3e9xA-1skyE:
undetectable		 3e9xA-1skyE:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmh TRIOSEPHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00121
(TIM) 		4 GLU A 137
GLY A 139
THR A 141
GLU A 142
 None
 1.14A 3e9xA-1tmhA:
undetectable		 3e9xA-1tmhA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLU A  83
GLY A  84
THR A  72
GLU A  86
 None
 1.13A 3e9xA-1tt7A:
undetectable		 3e9xA-1tt7A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		4 GLU A 667
GLY A 669
THR A 670
GLU A 671
 None
 1.12A 3e9xA-1w27A:
undetectable		 3e9xA-1w27A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		4 GLU A 269
GLY A 323
THR A 325
GLU A 326
 None
 1.22A 3e9xA-1wvgA:
undetectable		 3e9xA-1wvgA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqw PROLINE
IMINOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00561
(Abhydrolase_1) 		4 GLU A  27
GLY A  55
THR A  52
GLU A  54
 None
 1.22A 3e9xA-1xqwA:
undetectable		 3e9xA-1xqwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z24 INSECTICYANIN A FORM

(Manduca sexta) 		PF00061
(Lipocalin) 		4 GLU A 147
GLY A 143
THR A 145
GLU A 142
 None
 0.95A 3e9xA-1z24A:
undetectable		 3e9xA-1z24A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Bacteroides
thetaiotaomicron) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 GLU A  78
GLY A  58
THR A 103
GLU A 104
 None
 1.10A 3e9xA-1zybA:
undetectable		 3e9xA-1zybA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bo9 HUMAN LATEXIN

(Homo sapiens) 		PF06907
(Latexin) 		4 GLU B  60
GLY B  96
THR B  95
GLU B  94
 None
 0.98A 3e9xA-2bo9B:
undetectable		 3e9xA-2bo9B:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLU A 221
GLY A 154
THR A 155
GLU A 129
 None
 1.24A 3e9xA-2cx9A:
undetectable		 3e9xA-2cx9A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1m L-GLUTAMATE OXIDASE

(Streptomyces
sp. X-119-6) 		PF01593
(Amino_oxidase) 		4 GLU A 294
GLY A 297
THR A 298
GLU A 300
 None
 1.10A 3e9xA-2e1mA:
undetectable		 3e9xA-2e1mA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLU A 218
GLY A 159
THR A 160
GLU A 133
 None
 1.03A 3e9xA-2ebaA:
undetectable		 3e9xA-2ebaA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 GLU A 353
GLY A 169
THR A 329
GLU A 328
 None
 1.18A 3e9xA-2f43A:
undetectable		 3e9xA-2f43A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5j CASPASE-3, P17
SUBUNIT

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 GLU A 123
GLY A 165
THR A 166
GLU A 167
 None
 0.75A 3e9xA-2h5jA:
undetectable		 3e9xA-2h5jA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ism PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF07995
(GSDH) 		4 GLU A 195
GLY A 178
THR A 175
GLU A 177
 None
 0.99A 3e9xA-2ismA:
undetectable		 3e9xA-2ismA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLU A  84
GLY A  85
THR A  86
GLU A  87
 None
 1.15A 3e9xA-2j2mA:
undetectable		 3e9xA-2j2mA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jwp MALECTIN

(Xenopus laevis) 		PF11721
(Malectin) 		4 GLU A  19
GLY A  17
THR A  63
GLU A  64
 None
 0.93A 3e9xA-2jwpA:
undetectable		 3e9xA-2jwpA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mqe OMPA DOMAIN PROTEIN
TRANSMEMBRANE
REGION-CONTAINING
PROTEIN

(Escherichia
coli) 		PF00691
(OmpA) 		4 GLU A 254
GLY A 280
THR A 240
GLU A 281
 None
 1.13A 3e9xA-2mqeA:
undetectable		 3e9xA-2mqeA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn5 HYPOTHETICAL PROTEIN
EF_2215

(Enterococcus
faecalis) 		PF08327
(AHSA1) 		4 GLU A 104
GLY A  15
THR A  16
GLU A  17
 None
 1.14A 3e9xA-2nn5A:
undetectable		 3e9xA-2nn5A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 GLU A 426
GLY A 428
THR A 429
GLU A 430
 None
 0.93A 3e9xA-2pvsA:
0.7		 3e9xA-2pvsA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4q UPF0366 PROTEIN
C11ORF67

(Homo sapiens) 		PF04430
(DUF498) 		4 GLU A  40
GLY A  42
THR A  43
GLU A  44
 None
 0.77A 3e9xA-2q4qA:
undetectable		 3e9xA-2q4qA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermotoga
maritima) 		PF00342
(PGI) 		4 GLU A 362
GLY A 365
THR A 366
GLU A 367
 None
 1.21A 3e9xA-2q8nA:
undetectable		 3e9xA-2q8nA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe7 ATP SYNTHASE SUBUNIT
BETA

(Bacillus sp.
TA2.A1) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 GLU D 163
GLY D 131
THR D 130
GLU D 129
 None
 1.13A 3e9xA-2qe7D:
undetectable		 3e9xA-2qe7D:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 GLU A 346
GLY A 170
THR A 322
GLU A 321
 None
 1.10A 3e9xA-2r9vA:
undetectable		 3e9xA-2r9vA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Streptococcus
mutans) 		PF01182
(Glucosamine_iso) 		4 GLU A 135
GLY A 137
THR A 138
GLU A 208
 None
 0.87A 3e9xA-2ri0A:
undetectable		 3e9xA-2ri0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 GLU A 739
GLY A 740
THR A 741
GLU A 742
 None
 1.22A 3e9xA-2vycA:
undetectable		 3e9xA-2vycA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wse LHCA3

(Glycine max) 		PF00504
(Chloroa_b-bind) 		4 GLU 3  43
GLY 3  44
THR 3  45
GLU 3  50
 None
 1.08A 3e9xA-2wse3:
undetectable		 3e9xA-2wse3:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		4 GLU A 124
GLY A 129
THR A 128
GLU A 132
 None
 0.97A 3e9xA-2wsxA:
undetectable		 3e9xA-2wsxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxz LYSINE-SPECIFIC
DEMETHYLASE 6B

(Homo sapiens) 		PF02373
(JmjC) 		4 GLU A1389
GLY A1464
THR A1465
GLU A1412
 NI  A2494 ( 2.5A)
None
None
None
 1.21A 3e9xA-2xxzA:
undetectable		 3e9xA-2xxzA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 GLU A 302
GLY A 303
THR A 242
GLU A 241
 None
 1.02A 3e9xA-2yfnA:
undetectable		 3e9xA-2yfnA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE
SLIDING CLAMP

(Pyrococcus
furiosus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 GLU B 174
GLY B 170
THR B 172
GLU B 171
 None
 1.27A 3e9xA-3a2fB:
undetectable		 3e9xA-3a2fB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2f FERREDOXIN-1,
CHLOROPLASTIC

(Zea mays) 		PF00111
(Fer2) 		4 GLU A  13
GLY A  12
THR A   9
GLU A  11
 None
 1.03A 3e9xA-3b2fA:
undetectable		 3e9xA-3b2fA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		4 GLU A  97
GLY A  38
THR A   6
GLU A   7
 None
 0.98A 3e9xA-3b4wA:
undetectable		 3e9xA-3b4wA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl6 PUUE ALLANTOINASE

(Pseudomonas
fluorescens) 		PF01522
(Polysacc_deac_1) 		4 GLU A 154
GLY A 157
THR A 156
GLU A 158
 None
 1.05A 3e9xA-3cl6A:
undetectable		 3e9xA-3cl6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 GLU A 323
GLY A 321
THR A 320
GLU A 319
 None
 1.07A 3e9xA-3ecqA:
undetectable		 3e9xA-3ecqA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 GLU A 414
GLY A 420
THR A 422
GLU A 423
 BIX  A   1 ( 2.7A)
None
None
CA  A1755 (-2.2A)
 1.01A 3e9xA-3fedA:
undetectable		 3e9xA-3fedA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 GLU A 342
GLY A 343
THR A 344
GLU A 345
 None
 1.02A 3e9xA-3girA:
undetectable		 3e9xA-3girA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 GLU B 249
GLY A1271
THR A1268
GLU A1270
 None
 1.26A 3e9xA-3h0gB:
undetectable		 3e9xA-3h0gB:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il7 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Staphylococcus
aureus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 GLU A  96
GLY A  99
THR A 100
GLU A  71
 None
 1.15A 3e9xA-3il7A:
undetectable		 3e9xA-3il7A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkw PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 GLU A  14
GLY A  11
THR A  10
GLU A   9
 EDO  A 173 (-4.9A)
EDO  A 179 (-3.7A)
None
None
 1.26A 3e9xA-3kkwA:
undetectable		 3e9xA-3kkwA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
putida) 		PF07238
(PilZ)
PF07317
(YcgR) 		4 GLU A 172
GLY A 169
THR A 210
GLU A 168
 None
 1.23A 3e9xA-3kyfA:
undetectable		 3e9xA-3kyfA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 GLU A 252
GLY A 256
THR A 254
GLU A 690
 None
 1.18A 3e9xA-3lppA:
undetectable		 3e9xA-3lppA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muq UNCHARACTERIZED
CONSERVED PROTEIN

(Vibrio
parahaemolyticus) 		PF12849
(PBP_like_2) 		4 GLU A  88
GLY A  89
THR A  90
GLU A  93
 None
 1.18A 3e9xA-3muqA:
5.5		 3e9xA-3muqA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 GLU A  37
GLY A  93
THR A  90
GLU A  92
 None
 1.25A 3e9xA-3q3uA:
undetectable		 3e9xA-3q3uA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6m PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00160
(Pro_isomerase) 		4 GLU A 158
GLY A  38
THR A  39
GLU A  56
 None
 1.24A 3e9xA-3s6mA:
undetectable		 3e9xA-3s6mA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1u PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Azotobacter
vinelandii) 		PF00160
(Pro_isomerase) 		4 GLU A 158
GLY A  38
THR A  39
GLU A  56
 None
 1.27A 3e9xA-3t1uA:
undetectable		 3e9xA-3t1uA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t51 CATION EFFLUX SYSTEM
PROTEIN CUSB

(Escherichia
coli) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		4 GLU B 164
GLY B 180
THR B 178
GLU B 179
 None
 1.27A 3e9xA-3t51B:
undetectable		 3e9xA-3t51B:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 GLU A 332
GLY A 335
THR A 334
GLU A 340
 GLU  A 332 ( 0.6A)
GLY  A 335 ( 0.0A)
THR  A 334 ( 0.8A)
GLU  A 340 ( 0.6A)
 1.01A 3e9xA-3ulkA:
undetectable		 3e9xA-3ulkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 GLU A 333
GLY A 335
THR A 337
GLU A 340
 GLU  A 333 ( 0.6A)
GLY  A 335 ( 0.0A)
THR  A 337 ( 0.8A)
GLU  A 340 ( 0.6A)
 1.08A 3e9xA-3ulkA:
undetectable		 3e9xA-3ulkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		4 GLU A 330
GLY A 350
THR A 352
GLU A 349
 None
 1.02A 3e9xA-3vcyA:
undetectable		 3e9xA-3vcyA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a29 ENGINEERED
RETRO-ALDOL ENZYME
RA95.0

(synthetic
construct) 		PF00218
(IGPS) 		4 GLU A  53
GLY A  91
THR A  84
GLU A  86
 MLT  A 300 (-3.0A)
None
None
None
 0.99A 3e9xA-4a29A:
undetectable		 3e9xA-4a29A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af5 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR ACNR
COMPND 2

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		4 GLU A  38
GLY A  42
THR A  41
GLU A  15
 None
 1.07A 3e9xA-4af5A:
undetectable		 3e9xA-4af5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 GLU D 169
GLY D 137
THR D 136
GLU D 135
 None
 0.94A 3e9xA-4b2qD:
undetectable		 3e9xA-4b2qD:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLU A  16
GLY A  18
THR A  19
GLU A  20
 PG4  A1598 ( 4.4A)
None
None
None
 1.04A 3e9xA-4d5gA:
1.9		 3e9xA-4d5gA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Mycoplasma
penetrans) 		PF00145
(DNA_methylase) 		4 GLU A 242
GLY A 245
THR A 244
GLU A 389
 None
 1.15A 3e9xA-4dkjA:
undetectable		 3e9xA-4dkjA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B

(Mus musculus) 		PF02373
(JmjC) 		4 GLU A1392
GLY A1467
THR A1468
GLU A1415
 NI  A1701 ( 2.6A)
None
None
None
 1.09A 3e9xA-4eyuA:
undetectable		 3e9xA-4eyuA:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		4 GLU A 659
GLY A 662
THR A 663
GLU A 664
 ZN  A 703 ( 1.9A)
CEL  A 711 (-3.3A)
None
NAG  A 708 (-4.8A)
 0.82A 3e9xA-4fimA:
58.4		 3e9xA-4fimA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13365
(Trypsin_2) 		4 GLU A 200
GLY A 198
THR A 196
GLU A 197
 None
 1.23A 3e9xA-4ic5A:
undetectable		 3e9xA-4ic5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhm MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A  43
GLY A  45
THR A  46
GLU A  47
 None
 1.22A 3e9xA-4jhmA:
undetectable		 3e9xA-4jhmA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0v TEK TYROSINE KINASE
VARIANT

(Homo sapiens) 		PF00041
(fn3)
PF10430
(Ig_Tie2_1) 		4 GLU A 235
GLY A 238
THR A 237
GLU A 239
 None
 1.10A 3e9xA-4k0vA:
undetectable		 3e9xA-4k0vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k15 LMO2686 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 GLU A  57
GLY A  59
THR A  60
GLU A  61
 None
 0.96A 3e9xA-4k15A:
undetectable		 3e9xA-4k15A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nar PUTATIVE URONATE
ISOMERASE

(Thermotoga
maritima) 		PF09861
(DUF2088) 		4 GLU A 372
GLY A 360
THR A 361
GLU A 369
 None
 1.03A 3e9xA-4narA:
undetectable		 3e9xA-4narA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ps0 CASPASE-3

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 GLU A 123
GLY A 165
THR A 166
GLU A 167
 None
 0.65A 3e9xA-4ps0A:
0.9		 3e9xA-4ps0A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4l ATP SYNTHASE SUBUNIT
BETA 1

(Burkholderia
thailandensis) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 GLU A 178
GLY A 146
THR A 145
GLU A 144
 None
 1.05A 3e9xA-4q4lA:
undetectable		 3e9xA-4q4lA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR

(Bacillus
anthracis) 		PF00874
(PRD)
PF05043
(Mga)
PF08279
(HTH_11) 		4 GLU A 293
GLY A 297
THR A 295
GLU A 299
 None
 1.12A 3e9xA-4r6iA:
undetectable		 3e9xA-4r6iA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 GLU A 112
GLY A 133
THR A 151
GLU A 150
 None
 1.00A 3e9xA-4rvhA:
1.5		 3e9xA-4rvhA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE

(Providencia
alcalifaciens) 		PF00551
(Formyl_trans_N)
PF12796
(Ank_2) 		4 GLU A  75
GLY A 159
THR A 160
GLU A 161
 T3F  A 403 (-3.4A)
None
None
None
 1.00A 3e9xA-4xd0A:
undetectable		 3e9xA-4xd0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrw BEXL

(Amycolatopsis
orientalis) 		PF10604
(Polyketide_cyc2) 		4 GLU A 306
GLY A 253
THR A 254
GLU A 249
 None
 1.07A 3e9xA-4xrwA:
undetectable		 3e9xA-4xrwA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvg ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Escherichia
coli) 		PF07992
(Pyr_redox_2)
PF13192
(Thioredoxin_3) 		4 GLU A 200
GLY A 310
THR A 307
GLU A 306
 None
 1.10A 3e9xA-4xvgA:
undetectable		 3e9xA-4xvgA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		4 GLU A 117
GLY A 116
THR A 113
GLU A 115
 None
 1.13A 3e9xA-4yu9A:
undetectable		 3e9xA-4yu9A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgi TRAF-INTERACTING
PROTEIN WITH FHA
DOMAIN-CONTAINING
PROTEIN A

(Homo sapiens) 		PF00498
(FHA) 		4 GLU A 129
GLY A 131
THR A  12
GLU A  11
 None
 1.26A 3e9xA-4zgiA:
undetectable		 3e9xA-4zgiA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brj TWO COMPONENT
RESPONSE REGULATOR

(Agrobacterium
tumefaciens) 		PF00072
(Response_reg) 		4 GLU A  75
GLY A  38
THR A  39
GLU A  40
 None
 0.92A 3e9xA-5brjA:
1.9		 3e9xA-5brjA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eu6 HUMAN TCR HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU E  15
GLY E  17
THR E  83
GLU E  84
 None
 1.25A 3e9xA-5eu6E:
undetectable		 3e9xA-5eu6E:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 GLU D 200
GLY D 168
THR D 167
GLU D 166
 None
 1.08A 3e9xA-5fl7D:
undetectable		 3e9xA-5fl7D:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxv HISTONE DEMETHYLASE
UTY

(Homo sapiens) 		PF02373
(JmjC) 		4 GLU A1095
GLY A1170
THR A1171
GLU A1118
 MN  A2346 (-2.7A)
None
EDO  A2353 ( 4.9A)
None
 1.12A 3e9xA-5fxvA:
undetectable		 3e9xA-5fxvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2) 		PF01425
(Amidase) 		4 GLU A 311
GLY A 314
THR A 315
GLU A 316
 None
 1.18A 3e9xA-5h6sA:
0.9		 3e9xA-5h6sA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA

(Caldalkalibacillus
thermarum) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 GLU A 345
GLY A 169
THR A 321
GLU A 320
 None
 1.16A 3e9xA-5ik2A:
undetectable		 3e9xA-5ik2A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6y ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		PF07691
(PA14) 		4 GLU A  48
GLY A  19
THR A  46
GLU A  20
 None
None
None
CA  A 306 ( 4.9A)
 1.03A 3e9xA-5j6yA:
undetectable		 3e9xA-5j6yA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsi BACTERIORHODOPSIN

(Candidatus
Actinomarina
minuta) 		PF01036
(Bac_rhodopsin) 		4 GLU A 124
GLY A 115
THR A 117
GLU A 116
 None
None
None
IOD  A 316 (-2.4A)
 0.99A 3e9xA-5jsiA:
undetectable		 3e9xA-5jsiA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kja APOCAROTENOID-15,15'
-OXYGENASE

(Synechocystis
sp. PCC 6803) 		PF03055
(RPE65) 		4 GLU A 409
GLY A 411
THR A 412
GLU A 413
 None
 1.01A 3e9xA-5kjaA:
undetectable		 3e9xA-5kjaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 GLU A 368
GLY A 428
THR A 458
GLU A 457
 None
 1.04A 3e9xA-5necA:
undetectable		 3e9xA-5necA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npg LOQUACIOUS, ISOFORM
F

(Drosophila
melanogaster) 		PF00035
(dsrm) 		4 GLU A  36
GLY A  32
THR A  38
GLU A  31
 None
 1.02A 3e9xA-5npgA:
undetectable		 3e9xA-5npgA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens) 		no annotation 4 GLU B  34
GLY B  36
THR B  37
GLU B  40
 None
 1.22A 3e9xA-5thzB:
undetectable		 3e9xA-5thzB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utt SORTASE

(Actinomyces
oris) 		PF04203
(Sortase) 		4 GLU A 185
GLY A 183
THR A 182
GLU A 164
 None
 0.95A 3e9xA-5uttA:
undetectable		 3e9xA-5uttA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 4 GLU A 938
GLY A 940
THR A 941
GLU A 942
 None
 1.27A 3e9xA-5wlhA:
undetectable		 3e9xA-5wlhA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN

(Pyrococcus
horikoshii) 		no annotation 4 GLU A 158
GLY A 157
THR A 179
GLU A 156
 None
 1.24A 3e9xA-5x09A:
undetectable		 3e9xA-5x09A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfl CATENIN ALPHA-2

(Mus musculus) 		no annotation 4 GLU A 562
GLY A 564
THR A 567
GLU A 568
 None
 1.22A 3e9xA-5xflA:
undetectable		 3e9xA-5xflA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF

(Caldanaerobacter
subterraneus) 		no annotation 4 GLU A 304
GLY A 307
THR A 306
GLU A 308
 None
 1.06A 3e9xA-5z67A:
undetectable		 3e9xA-5z67A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4

(Homo sapiens) 		no annotation 4 GLU A1001
GLY A1026
THR A1028
GLU A1025
 None
 0.95A 3e9xA-6c90A:
undetectable		 3e9xA-6c90A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4

(Homo sapiens) 		no annotation 4 GLU M1001
GLY M1026
THR M1028
GLU M1025
 None
 0.97A 3e9xA-6d6qM:
undetectable		 3e9xA-6d6qM:
15.10