SIMILAR PATTERNS OF AMINO ACIDS FOR 3E9R_A_ACTA700_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		5 GLY A 137
TYR A 203
GLU A 204
GLY A 221
MET A 222
 8IG  A 306 (-3.3A)
8IG  A 306 (-4.4A)
8IG  A 306 (-2.8A)
8IG  A 306 (-3.4A)
8IG  A 306 (-4.0A)
 0.46A 3e9rA-1c3xA:
30.5		 3e9rA-1c3xA:
33.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		4 GLY A 221
TYR A 203
GLU A 204
GLY A 200
 8IG  A 306 (-3.4A)
8IG  A 306 (-4.4A)
8IG  A 306 (-2.8A)
None
 1.07A 3e9rA-1c3xA:
30.5		 3e9rA-1c3xA:
33.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Bacillus
subtilis) 		PF00215
(OMPdecase) 		4 GLY A 102
GLU A 105
GLY A 106
ASN A  71
 None
 0.79A 3e9rA-1dbtA:
undetectable		 3e9rA-1dbtA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 GLY A 448
GLU A 417
GLY A  90
ASN A 277
 None
 0.95A 3e9rA-1dq3A:
undetectable		 3e9rA-1dq3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihm CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 GLY A1363
TYR A1343
GLY A1365
ASN A1362
 None
 0.96A 3e9rA-1ihmA:
undetectable		 3e9rA-1ihmA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Trypanosoma
cruzi) 		PF01293
(PEPCK_ATP) 		4 GLY A  42
GLU A 284
GLY A 182
ASN A 305
 None
 1.06A 3e9rA-1ii2A:
undetectable		 3e9rA-1ii2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		4 GLY A  51
GLU A 296
GLY A 193
ASN A 317
 None
 1.05A 3e9rA-1j3bA:
undetectable		 3e9rA-1j3bA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jik TYROSYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00579
(tRNA-synt_1b) 		4 GLY A  72
GLY A  76
MET A  77
ASN A 123
 545  A 421 ( 4.8A)
None
None
None
 0.92A 3e9rA-1jikA:
undetectable		 3e9rA-1jikA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf6 THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		4 GLY A 101
TYR A 232
GLY A 220
MET A 199
 None
 0.92A 3e9rA-1qf6A:
undetectable		 3e9rA-1qf6A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r24 PROTEIN (IGG3-KAPPA
ANTIBODY (HEAVY
CHAIN))

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  54
GLY B  33
MET B  34
ASN B  74
 None
 0.95A 3e9rA-1r24B:
undetectable		 3e9rA-1r24B:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A  65
TYR A  68
GLY A  75
ASN A 105
 None
 1.05A 3e9rA-1rx0A:
undetectable		 3e9rA-1rx0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		4 TYR A  64
GLY A 316
MET A 260
ASN A  63
 None
 1.09A 3e9rA-1ur4A:
undetectable		 3e9rA-1ur4A:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		5 GLY A 118
GLU A 201
GLY A 218
MET A 219
ASN A 243
 HPA  A 300 (-3.6A)
HPA  A 300 ( 2.8A)
HPA  A 300 (-3.6A)
HPA  A 300 (-4.4A)
HPA  A 300 ( 2.9A)
 0.65A 3e9rA-1vfnA:
39.6		 3e9rA-1vfnA:
48.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vmk PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermotoga
maritima) 		PF01048
(PNP_UDP_1) 		6 GLY A 113
TYR A 185
GLU A 186
GLY A 203
MET A 204
ASN A 228
 GUN  A 300 (-3.5A)
GUN  A 300 (-4.6A)
GUN  A 300 (-2.7A)
GUN  A 300 (-3.4A)
GUN  A 300 (-4.3A)
GUN  A 300 (-3.3A)
 0.59A 3e9rA-1vmkA:
33.4		 3e9rA-1vmkA:
39.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLY A 117
TYR A 317
GLY A 119
ASN A 116
 GLY  A 117 ( 0.0A)
TYR  A 317 ( 1.3A)
GLY  A 119 ( 0.0A)
ASN  A 116 ( 0.6A)
 1.08A 3e9rA-1wqaA:
undetectable		 3e9rA-1wqaA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz8 ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		4 GLY A  62
TYR A 196
GLU A 112
GLY A  64
 None
 1.00A 3e9rA-1wz8A:
undetectable		 3e9rA-1wz8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		4 GLY A  32
TYR A 256
GLY A  78
ASN A 358
 None
 1.04A 3e9rA-1wzaA:
undetectable		 3e9rA-1wzaA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x99 LECTIN

(Xerocomellus
chrysenteron) 		PF07367
(FB_lectin) 		4 GLY A  55
TYR A  99
GLY A  72
ASN A  96
 None
 1.07A 3e9rA-1x99A:
undetectable		 3e9rA-1x99A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y2x LECTIN

(Agaricus
bisporus) 		PF07367
(FB_lectin) 		4 GLY A  52
TYR A  97
GLY A  70
ASN A  94
 None
 1.09A 3e9rA-1y2xA:
undetectable		 3e9rA-1y2xA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Actinobacillus
succinogenes) 		PF01293
(PEPCK_ATP) 		4 GLY A  64
GLU A 311
GLY A 209
ASN A 331
 None
 1.06A 3e9rA-1yggA:
undetectable		 3e9rA-1yggA:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yqq XANTHOSINE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		5 GLY A 119
GLU A 197
GLY A 214
MET A 215
ASN A 239
 GUN  A 400 (-3.5A)
GUN  A 400 (-2.8A)
GUN  A 400 (-3.5A)
GUN  A 400 (-4.1A)
GUN  A 400 (-3.2A)
 0.71A 3e9rA-1yqqA:
36.6		 3e9rA-1yqqA:
42.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 GLY A 222
GLU A 225
GLY A 220
ASN A 807
 None
 1.09A 3e9rA-2b3xA:
undetectable		 3e9rA-2b3xA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 GLY A 143
TYR A 242
GLY A 128
MET A 129
 FAD  A 600 (-3.0A)
None
FAD  A 600 ( 3.7A)
FAD  A 600 (-4.8A)
 0.87A 3e9rA-2bvgA:
undetectable		 3e9rA-2bvgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dby GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		4 GLY A  90
GLU A  87
GLY A  82
ASN A  91
 None
 1.08A 3e9rA-2dbyA:
2.0		 3e9rA-2dbyA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqa LYSOZYME

(Ruditapes
philippinarum) 		PF05497
(Destabilase) 		4 GLY A  97
TYR A  81
GLU A  93
GLY A 100
 None
 1.09A 3e9rA-2dqaA:
undetectable		 3e9rA-2dqaA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli;
Escherichia
coli) 		PF01019
(G_glu_transpept)
PF01019
(G_glu_transpept) 		4 GLY A  95
TYR B 408
GLY A 149
ASN A  92
 None
 1.03A 3e9rA-2e0xA:
undetectable		 3e9rA-2e0xA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 GLY A 525
GLU A 582
GLY A 562
ASN A 611
 None
 0.99A 3e9rA-2ecfA:
undetectable		 3e9rA-2ecfA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		4 GLY A 252
TYR A 277
GLY A 548
ASN A 288
 None
 1.09A 3e9rA-2et6A:
undetectable		 3e9rA-2et6A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewo PUTATIVE AGMATINE
DEIMINASE

(Streptococcus
mutans) 		PF04371
(PAD_porph) 		4 GLY A 355
GLU A 218
GLY A 357
ASN A  37
 None
 0.85A 3e9rA-2ewoA:
undetectable		 3e9rA-2ewoA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 GLY X 405
GLU X 372
GLY X 370
ASN X 444
 None
 1.03A 3e9rA-2f2lX:
undetectable		 3e9rA-2f2lX:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLY A 159
GLY A 161
MET A 162
ASN A 325
 NAP  A 367 ( 3.1A)
NAP  A 367 (-3.5A)
None
NAP  A 367 (-4.0A)
 0.96A 3e9rA-2gz3A:
undetectable		 3e9rA-2gz3A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i00 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 GLY A 220
GLU A 249
GLY A 167
ASN A 222
 None
 0.92A 3e9rA-2i00A:
undetectable		 3e9rA-2i00A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jer AGMATINE DEIMINASE

(Enterococcus
faecalis) 		PF04371
(PAD_porph) 		4 GLY A 351
GLU A 214
GLY A 353
ASN A  37
 None
AGT  A 357 ( 3.8A)
AGT  A 357 ( 3.8A)
AGT  A 357 ( 4.6A)
 0.93A 3e9rA-2jerA:
undetectable		 3e9rA-2jerA:
23.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE

(Anopheles
gambiae) 		PF01048
(PNP_UDP_1) 		5 GLY A 203
GLU A 286
GLY A 303
MET A 304
ASN A 328
 DIH  A 401 (-3.4A)
DIH  A 401 (-2.8A)
DIH  A 401 (-3.4A)
DIH  A 401 (-3.5A)
DIH  A 401 (-3.1A)
 0.53A 3e9rA-2p4sA:
39.9		 3e9rA-2p4sA:
35.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		4 GLY C 146
TYR C 190
GLY C 150
ASN C 145
 None
 0.93A 3e9rA-2vpwC:
undetectable		 3e9rA-2vpwC:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		4 GLY A  86
TYR A 144
GLY A  84
ASN A 160
 None
 0.96A 3e9rA-2vrkA:
undetectable		 3e9rA-2vrkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2w ARABINOFURANOSIDASE

(Bifidobacterium
longum) 		PF06964
(Alpha-L-AF_C) 		4 GLY A 126
TYR A 183
GLY A 124
ASN A 199
 None
 0.95A 3e9rA-2y2wA:
undetectable		 3e9rA-2y2wA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		4 GLY A 475
GLY A 673
MET A 676
ASN A 484
 None
GLU  A 301 (-3.2A)
None
None
 1.00A 3e9rA-2znsA:
undetectable		 3e9rA-2znsA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aut GLUCOSE
1-DEHYDROGENASE 4

(Bacillus
megaterium) 		PF13561
(adh_short_C2) 		4 GLY A  94
TYR A 158
GLU A  96
ASN A 116
 None
 1.08A 3e9rA-3autA:
3.0		 3e9rA-3autA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csq MORPHOGENESIS
PROTEIN 1

(Bacillus virus
phi29) 		no annotation 4 GLY A  51
TYR A  87
GLU A  93
GLY A  66
 None
 1.03A 3e9rA-3csqA:
undetectable		 3e9rA-3csqA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csz MORPHOGENESIS
PROTEIN 1

(Bacillus virus
phi29) 		no annotation 4 GLY A  51
TYR A  87
GLU A  93
GLY A  66
 None
 1.03A 3e9rA-3cszA:
undetectable		 3e9rA-3cszA:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		6 GLY A 120
TYR A 202
GLU A 203
GLY A 220
MET A 221
ASN A 245
 6GU  A 704 (-2.9A)
6GU  A 704 (-4.8A)
6GU  A 704 (-2.4A)
6GU  A 704 (-3.4A)
6GU  A 704 (-3.7A)
6GU  A 704 (-2.7A)
 0.28A 3e9rA-3e9zA:
48.5		 3e9rA-3e9zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iom PURINE NUCLEOSIDE
PHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF01048
(PNP_UDP_1) 		6 GLY A 122
TYR A 188
GLU A 189
GLY A 206
MET A 207
ASN A 231
 GNG  A 800 (-3.6A)
GNG  A 800 (-4.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.4A)
GNG  A 800 (-2.8A)
 0.65A 3e9rA-3iomA:
32.3		 3e9rA-3iomA:
34.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN

(Rhodobacter
sphaeroides) 		PF02126
(PTE) 		4 GLY A 132
GLU A 158
GLY A 130
MET A 129
 None
 1.05A 3e9rA-3k2gA:
undetectable		 3e9rA-3k2gA:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus) 		PF01048
(PNP_UDP_1) 		4 GLY A 115
GLU A 198
GLY A 215
MET A 216
 None
None
TRS  A 294 ( 3.9A)
TRS  A 294 (-3.7A)
 0.83A 3e9rA-3khsA:
36.8		 3e9rA-3khsA:
46.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus) 		PF01048
(PNP_UDP_1) 		4 GLY A 115
GLY A 215
MET A 216
ASN A 240
 None
TRS  A 294 ( 3.9A)
TRS  A 294 (-3.7A)
None
 0.49A 3e9rA-3khsA:
36.8		 3e9rA-3khsA:
46.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE

(Streptococcus
mutans) 		PF01048
(PNP_UDP_1) 		4 GLY A 115
TYR A 190
GLY A 208
MET A 209
 None
 0.24A 3e9rA-3la8A:
33.4		 3e9rA-3la8A:
40.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 GLY A 255
GLY A 261
MET A 260
ASN A  71
 None
 1.10A 3e9rA-3n23A:
undetectable		 3e9rA-3n23A:
13.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3odg XANTHOSINE
PHOSPHORYLASE

(Yersinia
pseudotuberculosis) 		PF01048
(PNP_UDP_1) 		5 GLY A 127
GLU A 205
GLY A 222
MET A 223
ASN A 247
 XAN  A 288 (-3.5A)
XAN  A 288 (-2.8A)
XAN  A 288 (-3.4A)
XAN  A 288 (-4.3A)
XAN  A 288 (-3.0A)
 0.59A 3e9rA-3odgA:
37.1		 3e9rA-3odgA:
41.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 GLY A 731
GLU A 868
GLY A 864
ASN A 352
 None
 1.09A 3e9rA-3ogrA:
undetectable		 3e9rA-3ogrA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oix PUTATIVE
DIHYDROOROTATE
DEHYDROGENASE
DIHYDROOROTATE
OXIDASE

(Streptococcus
mutans) 		PF01180
(DHO_dh) 		4 GLY A  47
GLY A 103
MET A 104
ASN A  75
 MLY  A  45 ( 3.8A)
None
None
None
 1.00A 3e9rA-3oixA:
undetectable		 3e9rA-3oixA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE

(Pseudomonas
aeruginosa) 		PF01048
(PNP_UDP_1) 		5 GLY A 102
GLU A 181
GLY A 198
MET A 199
ASN A 223
 HPA  A 260 (-3.7A)
HPA  A 260 (-2.9A)
HPA  A 260 (-3.3A)
HPA  A 260 (-4.3A)
HPA  A 260 (-3.0A)
 0.62A 3e9rA-3ozbA:
24.8		 3e9rA-3ozbA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdt BOLETUS EDULIS
LECTIN

(Boletus edulis) 		PF07367
(FB_lectin) 		4 GLY A  52
TYR A  96
GLY A  69
ASN A  93
 None
 1.09A 3e9rA-3qdtA:
undetectable		 3e9rA-3qdtA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		4 GLY A 458
GLY A 657
MET A 660
ASN A 468
 None
NDZ  A 301 (-3.4A)
None
None
 1.01A 3e9rA-3qxmA:
undetectable		 3e9rA-3qxmA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT

(uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 GLY A 475
TYR A 497
GLY A 484
MET A 485
 None
 1.09A 3e9rA-3sqgA:
undetectable		 3e9rA-3sqgA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u92 GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 GLY A  62
GLY A 140
MET A 143
ASN A  71
 None
KAI  A 258 (-3.3A)
None
None
 0.97A 3e9rA-3u92A:
undetectable		 3e9rA-3u92A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vte TETRAHYDROCANNABINOL
IC ACID SYNTHASE

(Cannabis sativa) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 GLY A 187
GLU A 236
GLY A 233
ASN A 483
 None
FAD  A 607 (-3.5A)
None
FAD  A 607 (-3.3A)
 0.98A 3e9rA-3vteA:
undetectable		 3e9rA-3vteA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		4 GLY A 113
GLU A 189
GLY A 269
MET A 272
 SQS  A 401 ( 4.2A)
None
None
SQS  A 401 (-3.5A)
 0.96A 3e9rA-3vzbA:
undetectable		 3e9rA-3vzbA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnv GLYOXYLATE REDUCTASE

(Paecilomyces
sp.
'thermophila') 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A 161
TYR A 182
GLY A 166
ASN A 184
 None
 1.07A 3e9rA-3wnvA:
undetectable		 3e9rA-3wnvA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhe PROBABLE GTP-BINDING
PROTEIN ENGB

(Burkholderia
thailandensis) 		PF01926
(MMR_HSR1) 		4 GLY A  84
GLY A  32
MET A 118
ASN A  35
 None
 1.00A 3e9rA-4dheA:
4.6		 3e9rA-4dheA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING

(Polaromonas sp.
JS666) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A 159
TYR A 180
GLY A 164
ASN A 182
 None
 1.10A 3e9rA-4g2nA:
undetectable		 3e9rA-4g2nA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcz BLUE-LIGHT
PHOTORECEPTOR,
SENSOR PROTEIN FIXL

(Bacillus
subtilis;
Bradyrhizobium
diazoefficiens) 		PF00512
(HisKA)
PF02518
(HATPase_c)
PF13426
(PAS_9) 		4 GLY A 361
GLY A 312
MET A 284
ASN A 358
 None
 1.09A 3e9rA-4gczA:
undetectable		 3e9rA-4gczA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcz BLUE-LIGHT
PHOTORECEPTOR,
SENSOR PROTEIN FIXL

(Bacillus
subtilis;
Bradyrhizobium
diazoefficiens) 		PF00512
(HisKA)
PF02518
(HATPase_c)
PF13426
(PAS_9) 		4 GLY A 362
GLY A 312
MET A 284
ASN A 358
 None
 1.03A 3e9rA-4gczA:
undetectable		 3e9rA-4gczA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl3 PUTATIVE
GLUCOAMYLASE

(Bacteroides
uniformis) 		PF10091
(Glycoamylase) 		4 GLY A 265
TYR A 257
GLY A 272
ASN A 253
 None
 1.06A 3e9rA-4gl3A:
undetectable		 3e9rA-4gl3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN

(Anaerococcus
prevotii) 		PF12710
(HAD) 		4 GLY A  51
GLU A  55
GLY A 216
ASN A  46
 GOL  A 405 ( 3.7A)
GOL  A 405 (-3.1A)
None
GOL  A 405 (-2.8A)
 0.87A 3e9rA-4gxtA:
undetectable		 3e9rA-4gxtA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htl BETA-GLUCOSIDE
KINASE

(Listeria
monocytogenes) 		PF00480
(ROK) 		4 GLY A 154
GLU A 152
GLY A 133
ASN A 172
 None
 1.07A 3e9rA-4htlA:
undetectable		 3e9rA-4htlA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htl BETA-GLUCOSIDE
KINASE

(Listeria
monocytogenes) 		PF00480
(ROK) 		4 GLY A 154
GLU A 152
GLY A 134
ASN A 172
 None
 0.86A 3e9rA-4htlA:
undetectable		 3e9rA-4htlA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A  72
GLY A  76
MET A  79
ASN A 112
 None
 0.91A 3e9rA-4k9qA:
undetectable		 3e9rA-4k9qA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l05 SUPEROXIDE DISMUTASE
[CU-ZN]

(Brucella
abortus) 		PF00080
(Sod_Cu) 		4 GLY A 142
GLU A 139
GLY A 144
ASN A 133
 None
 1.08A 3e9rA-4l05A:
undetectable		 3e9rA-4l05A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lkr PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		4 GLY A 156
TYR A 159
GLY A  65
MET A  64
 None
 1.10A 3e9rA-4lkrA:
20.1		 3e9rA-4lkrA:
25.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lna PURINE NUCLEOSIDE
PHOSPHORYLASE

(Spirosoma
linguale) 		PF01048
(PNP_UDP_1) 		4 GLY A 113
GLU A 192
GLY A 209
MET A 210
 ADE  A 502 (-3.6A)
ADE  A 502 (-2.9A)
ADE  A 502 (-3.5A)
MPD  A 503 ( 3.2A)
 0.48A 3e9rA-4lnaA:
38.6		 3e9rA-4lnaA:
43.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE

(Planctopirus
limnophila) 		PF01048
(PNP_UDP_1) 		4 GLY A 116
GLU A 194
GLY A 211
MET A 212
 ADE  A 401 (-3.7A)
ADE  A 401 (-2.7A)
ADE  A 401 (-3.4A)
ADE  A 401 (-4.2A)
 0.48A 3e9rA-4m1eA:
38.4		 3e9rA-4m1eA:
43.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Porphyromonas
gingivalis) 		PF01048
(PNP_UDP_1) 		6 GLY A 131
TYR A 207
GLU A 208
GLY A 225
MET A 226
ASN A 250
 DA  A 301 (-3.4A)
None
DA  A 301 (-2.7A)
DA  A 301 (-3.5A)
DA  A 301 (-4.0A)
DA  A 301 (-3.0A)
 0.42A 3e9rA-4ns1A:
39.8		 3e9rA-4ns1A:
45.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Porphyromonas
gingivalis) 		PF01048
(PNP_UDP_1) 		4 GLY A 225
TYR A 207
GLU A 208
GLY A 204
 DA  A 301 (-3.5A)
None
DA  A 301 (-2.7A)
None
 1.03A 3e9rA-4ns1A:
39.8		 3e9rA-4ns1A:
45.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 GLY A 140
TYR A 468
GLY A 219
ASN A 167
 None
 1.08A 3e9rA-4o6rA:
undetectable		 3e9rA-4o6rA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 GLY A2093
TYR A2111
GLY A2137
ASN A2090
 None
 1.04A 3e9rA-4o9xA:
undetectable		 3e9rA-4o9xA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)

(Streptococcus
parasanguinis) 		PF08759
(GT-D) 		4 GLY A 154
TYR A 228
GLU A 229
GLY A 156
 None
 1.08A 3e9rA-4phsA:
undetectable		 3e9rA-4phsA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1j POLYKETIDE
BIOSYNTHESIS
ENOYL-COA ISOMERASE
PKSI

(Bacillus
subtilis) 		PF00378
(ECH_1) 		4 GLY A 107
TYR A 134
GLY A  65
ASN A 130
 None
 1.07A 3e9rA-4q1jA:
undetectable		 3e9rA-4q1jA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1j POLYKETIDE
BIOSYNTHESIS
ENOYL-COA ISOMERASE
PKSI

(Bacillus
subtilis) 		PF00378
(ECH_1) 		4 GLY A 107
TYR A 134
GLY A  66
ASN A 130
 None
 0.87A 3e9rA-4q1jA:
undetectable		 3e9rA-4q1jA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4n HIV-1 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 GLY A 458
GLU A 466
GLY A 460
ASN A 280
 None
 1.03A 3e9rA-4r4nA:
undetectable		 3e9rA-4r4nA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roa SERPIN 2

(Anopheles
gambiae) 		PF00079
(Serpin) 		4 GLY A 357
TYR A 361
GLY A 199
ASN A 354
 None
 0.89A 3e9rA-4roaA:
undetectable		 3e9rA-4roaA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1i PYRIDOXAL KINASE

(Entamoeba
histolytica) 		PF08543
(Phos_pyr_kin) 		4 GLY B  18
TYR B  11
GLY B  22
MET B  23
 PLP  B 302 ( 4.4A)
None
None
None
 1.05A 3e9rA-4s1iB:
2.4		 3e9rA-4s1iB:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Agrobacterium
vitis) 		PF01048
(PNP_UDP_1) 		5 GLY A 110
GLU A 185
GLY A 202
MET A 203
ASN A 227
 HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.61A 3e9rA-4uc0A:
33.0		 3e9rA-4uc0A:
35.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2q LECTIN

(Athelia rolfsii) 		PF07367
(FB_lectin) 		4 GLY A  51
TYR A  95
GLY A  68
ASN A  92
 None
 1.08A 3e9rA-4z2qA:
undetectable		 3e9rA-4z2qA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		4 GLY A 240
GLU A 244
GLY A 238
ASN A 523
 None
 0.98A 3e9rA-5hqnA:
undetectable		 3e9rA-5hqnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		4 GLY A 242
GLU A 246
GLY A 240
ASN A 525
 None
 1.01A 3e9rA-5i85A:
undetectable		 3e9rA-5i85A:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE

(Kluyveromyces
lactis) 		PF01048
(PNP_UDP_1) 		5 GLY A 131
GLU A 214
GLY A 231
MET A 232
ASN A 256
 HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
 0.49A 3e9rA-5ifkA:
39.6		 3e9rA-5ifkA:
42.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		4 GLY A 234
GLY A 232
MET A 231
ASN A  26
 None
 1.07A 3e9rA-5jc8A:
3.3		 3e9rA-5jc8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga) 		no annotation 4 GLY B 591
TYR B 609
GLY B 635
ASN B 588
 None
 0.96A 3e9rA-5kisB:
undetectable		 3e9rA-5kisB:
14.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		6 GLY A 120
TYR A 202
GLU A 203
GLY A 220
MET A 221
ASN A 245
 CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
 1.06A 3e9rA-5ko5A:
43.9		 3e9rA-5ko5A:
62.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 GLY A 458
GLY A 657
MET A 660
ASN A 468
 None
SYM  A 901 (-3.1A)
None
None
 0.85A 3e9rA-5kufA:
undetectable		 3e9rA-5kufA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm2 CAPSID PROTEIN VP4B
CAPSID PROTEIN VP4A

(Nora virus;
Nora virus) 		no annotation
no annotation 		4 GLY C  37
GLU B   8
GLY B   9
ASN B 120
 None
 0.98A 3e9rA-5mm2C:
undetectable		 3e9rA-5mm2C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sga PROTEINASE A (SGPA)

(Streptomyces
griseus) 		PF00089
(Trypsin) 		4 GLU E 233
GLY E 179
MET E 180
ASN E 100
 None
 1.10A 3e9rA-5sgaE:
undetectable		 3e9rA-5sgaE:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucy TUBULIN ALPHA CHAIN

(Tetrahymena
thermophila) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 GLY A 144
GLU A  71
GLY A  10
ASN A 101
 GTP  A 501 (-2.2A)
GTP  A 501 ( 1.8A)
GTP  A 501 (-2.2A)
GTP  A 501 (-3.3A)
 0.79A 3e9rA-5ucyA:
undetectable		 3e9rA-5ucyA:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 GLY A 118
GLU A 201
GLY A 218
MET A 219
ASN A 243
 IM5  A 308 (-3.7A)
IM5  A 308 (-2.9A)
IM5  A 308 (-3.4A)
IM5  A 308 (-3.5A)
IM5  A 308 (-3.1A)
 0.62A 3e9rA-5ugfA:
40.3		 3e9rA-5ugfA:
44.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4a GLYCOSYLTRANSFERASE
(DUF1792)

(Streptococcus
sanguinis) 		PF08759
(GT-D) 		4 GLY A 154
TYR A 228
GLU A 229
GLY A 156
 None
 1.03A 3e9rA-5v4aA:
undetectable		 3e9rA-5v4aA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd0 GLUCANASE

(Paenibacillus
sp. X4) 		PF01270
(Glyco_hydro_8) 		4 GLY A 157
TYR A 125
GLY A  98
MET A 101
 None
 0.97A 3e9rA-5xd0A:
undetectable		 3e9rA-5xd0A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 4 GLY A 528
GLU A 585
GLY A 565
ASN A 614
 None
 0.85A 3e9rA-5yp3A:
undetectable		 3e9rA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 4 GLY A 529
GLU A 585
GLY A 565
ASN A 614
 None
 1.08A 3e9rA-5yp3A:
undetectable		 3e9rA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT D

(Saccharomyces
cerevisiae) 		no annotation 4 GLY B  11
GLU B  14
GLY B  15
ASN B   7
 None
 0.82A 3e9rA-6c6lB:
undetectable		 3e9rA-6c6lB:
undetectable