SIMILAR PATTERNS OF AMINO ACIDS FOR 3E7G_C_H4BC2902_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwy PROTEIN (HEART FATTY
ACID BINDING
PROTEIN)

(Bos taurus) 		PF00061
(Lipocalin) 		4 ARG A 106
ILE A  50
PHE A  64
GLU A  72
 None
 1.16A 3e7gC-1bwyA:
undetectable
3e7gD-1bwyA:
undetectable		 3e7gC-1bwyA:
15.70
3e7gD-1bwyA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4p PROTEIN
(STREPTOKINASE)

(Streptococcus
dysgalactiae) 		PF02821
(Staphylokinase) 		4 ARG A 219
ILE A 270
PHE A 241
GLU A 198
 None
 1.47A 3e7gC-1c4pA:
0.0
3e7gD-1c4pA:
0.0		 3e7gC-1c4pA:
15.40
3e7gD-1c4pA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2z DEATH DOMAIN OF TUBE

(Drosophila
melanogaster) 		PF14786
(Death_2) 		4 MET B  65
ILE B  61
TRP B 117
GLU B 125
 None
 1.45A 3e7gC-1d2zB:
0.0
3e7gD-1d2zB:
0.0		 3e7gC-1d2zB:
17.43
3e7gD-1d2zB:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE

(Lactobacillus
casei) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ARG A  75
ILE A   3
PHE A  16
GLU A  28
 None
 1.44A 3e7gC-1dxyA:
0.0
3e7gD-1dxyA:
0.0		 3e7gC-1dxyA:
21.69
3e7gD-1dxyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hra RETINOIC ACID
RECEPTOR

(Homo sapiens) 		PF00105
(zf-C4) 		4 MET A  73
ARG A  59
ILE A  36
PHE A  31
 None
ZN  A  81 ( 4.9A)
None
None
 1.12A 3e7gC-1hraA:
undetectable
3e7gD-1hraA:
undetectable		 3e7gC-1hraA:
9.50
3e7gD-1hraA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kex NEUROPILIN-1

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		4 ARG A 130
TRP A  97
PHE A 131
GLU A  95
 None
 1.45A 3e7gC-1kexA:
undetectable
3e7gD-1kexA:
undetectable		 3e7gC-1kexA:
18.21
3e7gD-1kexA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kob TWITCHIN

(Aplysia
californica) 		PF00069
(Pkinase) 		4 ILE A 152
TRP A 307
PHE A 284
GLU A 280
 None
 1.36A 3e7gC-1kobA:
0.0
3e7gD-1kobA:
0.0		 3e7gC-1kobA:
21.48
3e7gD-1kobA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp0 CREATINE
AMIDINOHYDROLASE

(Actinobacillus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 MET A 215
ARG A  90
ILE A 205
PHE A 254
 None
 1.38A 3e7gC-1kp0A:
0.0
3e7gD-1kp0A:
0.0		 3e7gC-1kp0A:
20.31
3e7gD-1kp0A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 ILE A  27
TRP A  23
PHE A  20
GLU A  22
 None
 1.28A 3e7gC-1nj1A:
0.3
3e7gD-1nj1A:
0.1		 3e7gC-1nj1A:
22.48
3e7gD-1nj1A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsa PROCARBOXYPEPTIDASE
B

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 ARG A  35
ILE A  18
TRP A  15
GLU A  16
 None
 1.03A 3e7gC-1nsaA:
0.0
3e7gD-1nsaA:
0.0		 3e7gC-1nsaA:
23.31
3e7gD-1nsaA:
23.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 MET A 114
ARG A 375
ILE A 456
TRP A 457
 H4B  A 901 (-4.0A)
H4B  A 901 (-3.4A)
H4B  A 901 (-4.7A)
H4B  A 901 ( 3.7A)
 0.32A 3e7gC-1qw5A:
60.3
3e7gD-1qw5A:
60.4		 3e7gC-1qw5A:
87.14
3e7gD-1qw5A:
87.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzq EQUINATOXIN II

(Actinia equina) 		PF06369
(Anemone_cytotox) 		4 ARG A 152
ILE A 174
TRP A 117
PHE A 143
 None
 1.50A 3e7gC-1tzqA:
undetectable
3e7gD-1tzqA:
undetectable		 3e7gC-1tzqA:
18.35
3e7gD-1tzqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 ILE A 371
TRP A 368
PHE A 383
GLU A 369
 None
 1.23A 3e7gC-1w1kA:
undetectable
3e7gD-1w1kA:
undetectable		 3e7gC-1w1kA:
21.51
3e7gD-1w1kA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens) 		PF00246
(Peptidase_M14) 		4 ARG A  35
ILE A  18
TRP A  15
GLU A  16
 None
 0.94A 3e7gC-1zliA:
undetectable
3e7gD-1zliA:
undetectable		 3e7gC-1zliA:
21.72
3e7gD-1zliA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Pyrococcus
abyssi) 		PF00710
(Asparaginase) 		4 ARG A  10
ILE A  59
PHE A   6
GLU A  62
 None
 1.29A 3e7gC-1zq1A:
undetectable
3e7gD-1zq1A:
undetectable		 3e7gC-1zq1A:
21.06
3e7gD-1zq1A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b87 ANTI-ZTAQ AFFIBODY
ZTAQ AFFIBODY

(Staphylococcus
aureus) 		PF02216
(B) 		4 ILE B  13
TRP A  14
PHE A  17
GLU A  15
 None
 1.39A 3e7gC-2b87B:
undetectable
3e7gD-2b87B:
undetectable		 3e7gC-2b87B:
8.79
3e7gD-2b87B:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		4 MET A 164
ILE A 176
PHE A 138
GLU A 167
 None
 1.39A 3e7gC-2bwgA:
undetectable
3e7gD-2bwgA:
undetectable		 3e7gC-2bwgA:
21.11
3e7gD-2bwgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzn GMP REDUCTASE 2

(Homo sapiens) 		PF00478
(IMPDH) 		4 MET A 164
ILE A 176
PHE A 138
GLU A 167
 None
 1.48A 3e7gC-2bznA:
0.1
3e7gD-2bznA:
0.1		 3e7gC-2bznA:
21.80
3e7gD-2bznA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy7 CYSTEINE PROTEASE
APG4B

(Homo sapiens) 		PF03416
(Peptidase_C54) 		4 ARG A  55
ILE A 294
PHE A 299
GLU A 297
 None
 1.26A 3e7gC-2cy7A:
undetectable
3e7gD-2cy7A:
undetectable		 3e7gC-2cy7A:
22.39
3e7gD-2cy7A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		4 ILE A 320
TRP A 288
PHE A 236
GLU A 239
 None
None
None
MG  A2001 ( 2.9A)
 1.45A 3e7gC-2dw6A:
undetectable
3e7gD-2dw6A:
0.1		 3e7gC-2dw6A:
23.23
3e7gD-2dw6A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		4 ARG A 256
ILE A 201
PHE A 257
GLU A 170
 None
 1.39A 3e7gC-2e3zA:
undetectable
3e7gD-2e3zA:
undetectable		 3e7gC-2e3zA:
22.99
3e7gD-2e3zA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyn ALPHA-ACTININ 1

(Homo sapiens) 		PF00307
(CH) 		4 ARG A 187
ILE A 218
PHE A 249
GLU A 257
 None
 1.18A 3e7gC-2eynA:
undetectable
3e7gD-2eynA:
undetectable		 3e7gC-2eynA:
19.53
3e7gD-2eynA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		4 ARG A 202
TRP A  93
PHE A  99
GLU A 101
 GUN  A 503 (-3.7A)
None
None
None
 1.28A 3e7gC-2i9uA:
0.8
3e7gD-2i9uA:
0.7		 3e7gC-2i9uA:
21.71
3e7gD-2i9uA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 257
ILE A 248
TRP A 245
PHE A 240
 None
 1.12A 3e7gC-2jc6A:
undetectable
3e7gD-2jc6A:
undetectable		 3e7gC-2jc6A:
20.59
3e7gD-2jc6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2x HYPOTHETICAL PROTEIN

(Mesorhizobium
loti) 		PF13242
(Hydrolase_like) 		4 ARG A  37
ILE A  83
TRP A  90
PHE A  93
 None
 1.49A 3e7gC-2o2xA:
undetectable
3e7gD-2o2xA:
undetectable		 3e7gC-2o2xA:
21.45
3e7gD-2o2xA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlz TRANSCRIPTION FACTOR
PF0095

(Pyrococcus
furiosus) 		PF12840
(HTH_20) 		4 ARG A 102
ILE A 106
PHE A 104
GLU A 133
 None
 1.47A 3e7gC-2qlzA:
undetectable
3e7gD-2qlzA:
undetectable		 3e7gC-2qlzA:
17.14
3e7gD-2qlzA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm3 PREDICTED
METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01861
(DUF43) 		4 ILE A 267
TRP A 264
PHE A 252
GLU A 227
 None
 1.47A 3e7gC-2qm3A:
undetectable
3e7gD-2qm3A:
undetectable		 3e7gC-2qm3A:
22.45
3e7gD-2qm3A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425

(Thermoplasma
volcanium) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		4 ARG A  25
ILE A  17
PHE A  55
GLU A  53
 None
None
None
BU2  A 196 (-3.2A)
 0.91A 3e7gC-2rfmA:
undetectable
3e7gD-2rfmA:
undetectable		 3e7gC-2rfmA:
18.94
3e7gD-2rfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 205
TRP A 360
PHE A 337
GLU A 333
 None
 1.41A 3e7gC-2x4fA:
undetectable
3e7gD-2x4fA:
undetectable		 3e7gC-2x4fA:
23.29
3e7gD-2x4fA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycd GLUTATHIONE
S-TRANSFERASE

(Agrobacterium
tumefaciens) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 ILE A 179
TRP A  40
PHE A 213
GLU A  43
 None
 1.41A 3e7gC-2ycdA:
undetectable
3e7gD-2ycdA:
0.2		 3e7gC-2ycdA:
19.57
3e7gD-2ycdA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		4 ARG A  17
ILE A  28
PHE A 358
GLU A 323
 None
 1.35A 3e7gC-2ywbA:
undetectable
3e7gD-2ywbA:
undetectable		 3e7gC-2ywbA:
21.25
3e7gD-2ywbA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf8 COMPONENT OF
SODIUM-DRIVEN POLAR
FLAGELLAR MOTOR

(Vibrio
alginolyticus) 		PF00691
(OmpA) 		4 MET A  17
TRP A  15
PHE A 137
GLU A  16
 None
 1.41A 3e7gC-2zf8A:
undetectable
3e7gD-2zf8A:
undetectable		 3e7gC-2zf8A:
18.96
3e7gD-2zf8A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		4 ARG A 258
ILE A 253
PHE A 267
GLU A 221
 None
 1.42A 3e7gC-3a4tA:
undetectable
3e7gD-3a4tA:
undetectable		 3e7gC-3a4tA:
20.42
3e7gD-3a4tA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chl ALPHA-14 GIARDIN

(Giardia
intestinalis) 		PF00191
(Annexin) 		4 ARG A 198
ILE A 111
PHE A 239
GLU A 275
 None
 1.42A 3e7gC-3chlA:
undetectable
3e7gD-3chlA:
undetectable		 3e7gC-3chlA:
22.00
3e7gD-3chlA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB) 		4 ARG A 437
TRP A 485
PHE A 489
GLU A 484
 None
 1.02A 3e7gC-3ckbA:
undetectable
3e7gD-3ckbA:
undetectable		 3e7gC-3ckbA:
20.93
3e7gD-3ckbA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfa CALCIUM-DEPENDENT
PROTEIN KINASE
CGD3_920

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ARG A 241
ILE A 232
TRP A 229
PHE A 224
 None
 1.08A 3e7gC-3dfaA:
undetectable
3e7gD-3dfaA:
undetectable		 3e7gC-3dfaA:
21.33
3e7gD-3dfaA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ARG A 260
TRP A 248
PHE A 243
GLU A 245
 None
 1.32A 3e7gC-3f3zA:
undetectable
3e7gD-3f3zA:
undetectable		 3e7gC-3f3zA:
20.80
3e7gD-3f3zA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3o VACUOLAR TRANSPORTER
CHAPERONE 2

(Saccharomyces
cerevisiae) 		PF09359
(VTC) 		4 ARG A 440
ILE A 391
PHE A 353
GLU A 395
 None
 1.22A 3e7gC-3g3oA:
undetectable
3e7gD-3g3oA:
undetectable		 3e7gC-3g3oA:
20.70
3e7gD-3g3oA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ARG A  52
ILE A 333
PHE A  20
GLU A 310
 None
 1.26A 3e7gC-3gazA:
undetectable
3e7gD-3gazA:
0.0		 3e7gC-3gazA:
22.83
3e7gD-3gazA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggy INCREASED SODIUM
TOLERANCE PROTEIN 1

(Saccharomyces
cerevisiae) 		PF03398
(Ist1) 		4 ARG A 110
ILE A  90
PHE A 140
GLU A  94
 None
 1.46A 3e7gC-3ggyA:
undetectable
3e7gD-3ggyA:
undetectable		 3e7gC-3ggyA:
17.41
3e7gD-3ggyA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ARG A 310
ILE A 301
TRP A 298
PHE A 293
 SRT  A 543 (-3.8A)
None
None
None
 1.07A 3e7gC-3igoA:
undetectable
3e7gD-3igoA:
undetectable		 3e7gC-3igoA:
21.88
3e7gD-3igoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		no annotation 4 MET K 958
ILE K 924
TRP K 954
PHE K 972
 None
 1.23A 3e7gC-3jblK:
undetectable
3e7gD-3jblK:
undetectable		 3e7gC-3jblK:
19.30
3e7gD-3jblK:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lim FRAGACEATOXIN C

(Actinia
fragacea) 		PF06369
(Anemone_cytotox) 		4 ARG A 152
ILE A 174
TRP A 117
PHE A 143
 None
 1.47A 3e7gC-3limA:
undetectable
3e7gD-3limA:
undetectable		 3e7gC-3limA:
16.35
3e7gD-3limA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE

(Homo sapiens) 		PF05577
(Peptidase_S28) 		4 MET B 410
ILE B 407
TRP B 406
TRP B 187
 None
 1.17A 3e7gC-3n2zB:
undetectable
3e7gD-3n2zB:
undetectable		 3e7gC-3n2zB:
21.97
3e7gD-3n2zB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q63 MLL2253 PROTEIN

(Mesorhizobium
japonicum) 		PF08327
(AHSA1) 		4 MET A 108
TRP A 128
PHE A 113
GLU A 109
 None
 1.43A 3e7gC-3q63A:
undetectable
3e7gD-3q63A:
undetectable		 3e7gC-3q63A:
15.71
3e7gD-3q63A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 ARG A 397
ILE A 467
TRP A 464
GLU A 465
 None
 1.20A 3e7gC-3rblA:
undetectable
3e7gD-3rblA:
undetectable		 3e7gC-3rblA:
20.56
3e7gD-3rblA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zid TUBULIN/FTSZ, GTPASE

(Methanothrix
thermoacetophila) 		PF00091
(Tubulin) 		4 ARG A  42
ILE A  46
PHE A 103
GLU A  98
 None
 1.43A 3e7gC-3zidA:
undetectable
3e7gD-3zidA:
undetectable		 3e7gC-3zidA:
22.79
3e7gD-3zidA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be3 ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		4 ILE A 269
TRP A 190
PHE A 259
GLU A 179
 None
 1.16A 3e7gC-4be3A:
undetectable
3e7gD-4be3A:
undetectable		 3e7gC-4be3A:
21.35
3e7gD-4be3A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ARG A 207
ILE A 156
PHE A 208
GLU A 245
 None
 1.42A 3e7gC-4c7vA:
undetectable
3e7gD-4c7vA:
undetectable		 3e7gC-4c7vA:
20.75
3e7gD-4c7vA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14

(Kluyveromyces
lactis) 		PF05843
(Suf) 		4 ILE A 161
TRP A 170
PHE A 169
GLU A 163
 None
 1.46A 3e7gC-4ebaA:
undetectable
3e7gD-4ebaA:
undetectable		 3e7gC-4ebaA:
21.11
3e7gD-4ebaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 254
ILE A 245
TRP A 242
PHE A 237
 None
 1.13A 3e7gC-4fg8A:
undetectable
3e7gD-4fg8A:
undetectable		 3e7gC-4fg8A:
22.39
3e7gD-4fg8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im4 ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		4 ILE A 175
TRP A 172
PHE A 188
GLU A 173
 None
 1.34A 3e7gC-4im4A:
0.0
3e7gD-4im4A:
0.1		 3e7gC-4im4A:
21.74
3e7gD-4im4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ILE B 422
TRP B 355
PHE B 342
GLU B 424
 None
 1.35A 3e7gC-4l37B:
undetectable
3e7gD-4l37B:
undetectable		 3e7gC-4l37B:
19.88
3e7gD-4l37B:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		4 ARG A 637
ILE A 630
PHE A 695
GLU A 692
 None
 1.40A 3e7gC-4ncnA:
0.5
3e7gD-4ncnA:
undetectable		 3e7gC-4ncnA:
21.12
3e7gD-4ncnA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnz PROBABLE ZINC
PROTEASE

(Pseudomonas
aeruginosa) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 MET A 360
ARG A 269
ILE A 387
GLU A 363
 None
 1.22A 3e7gC-4nnzA:
undetectable
3e7gD-4nnzA:
undetectable		 3e7gC-4nnzA:
23.28
3e7gD-4nnzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnz PROBABLE ZINC
PROTEASE

(Pseudomonas
aeruginosa) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 MET A 360
ARG A 269
ILE A 387
PHE A 304
 None
 1.09A 3e7gC-4nnzA:
undetectable
3e7gD-4nnzA:
undetectable		 3e7gC-4nnzA:
23.28
3e7gD-4nnzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN

(Saccharopolyspora
spinosa) 		PF08241
(Methyltransf_11) 		4 ARG A  75
ILE A 101
PHE A 141
GLU A 162
 None
SAH  A 301 ( 4.1A)
None
None
 1.42A 3e7gC-4pneA:
undetectable
3e7gD-4pneA:
undetectable		 3e7gC-4pneA:
22.22
3e7gD-4pneA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Homo sapiens) 		PF12157
(DUF3591) 		4 ARG A 890
ILE A 897
TRP A 837
GLU A 895
 None
 1.47A 3e7gC-4rgwA:
undetectable
3e7gD-4rgwA:
undetectable		 3e7gC-4rgwA:
21.14
3e7gD-4rgwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmz EIF5B

(Chaetomium
thermophilum) 		no annotation 4 ARG B 637
ILE B 630
PHE B 695
GLU B 692
 None
 1.47A 3e7gC-4tmzB:
undetectable
3e7gD-4tmzB:
undetectable		 3e7gC-4tmzB:
23.93
3e7gD-4tmzB:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trb PURINE
PHOSPHORIBOSYLTRANSF
ERASE (GPT-1)

(Sulfolobus
solfataricus) 		PF00156
(Pribosyltran) 		4 ARG A 206
ILE A 200
TRP A 156
GLU A 157
 None
 1.24A 3e7gC-4trbA:
undetectable
3e7gD-4trbA:
undetectable		 3e7gC-4trbA:
20.44
3e7gD-4trbA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 ARG A 276
ILE A 271
PHE A 264
GLU A 266
 None
 1.23A 3e7gC-4xj6A:
undetectable
3e7gD-4xj6A:
undetectable		 3e7gC-4xj6A:
22.95
3e7gD-4xj6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x REELIN

(Mus musculus) 		PF07974
(EGF_2) 		4 ILE A2396
TRP A2459
TRP A2471
PHE A2357
 None
 1.38A 3e7gC-5b4xA:
undetectable
3e7gD-5b4xA:
undetectable		 3e7gC-5b4xA:
19.78
3e7gD-5b4xA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Homo sapiens) 		PF12157
(DUF3591) 		4 ARG G 890
ILE G 897
TRP G 837
GLU G 895
 None
 1.47A 3e7gC-5furG:
undetectable
3e7gD-5furG:
undetectable		 3e7gC-5furG:
12.64
3e7gD-5furG:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwt SENSOR HISTIDINE
KINASE TODS

(Pseudomonas
putida) 		PF08448
(PAS_4) 		4 ILE A 114
TRP A  84
PHE A 128
GLU A  45
 None
 1.34A 3e7gC-5hwtA:
undetectable
3e7gD-5hwtA:
undetectable		 3e7gC-5hwtA:
16.35
3e7gD-5hwtA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnu LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Mus musculus) 		PF01451
(LMWPc) 		4 ARG A  40
ILE A  77
PHE A  85
GLU A  80
 None
 1.43A 3e7gC-5jnuA:
undetectable
3e7gD-5jnuA:
undetectable		 3e7gC-5jnuA:
16.71
3e7gD-5jnuA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE

(Helicobacter
pylori) 		PF01048
(PNP_UDP_1) 		4 MET A  10
ARG A 194
ILE A  14
GLU A  12
 4CT  A 301 ( 2.9A)
4CT  A 301 ( 4.2A)
None
None
 1.41A 3e7gC-5k1zA:
undetectable
3e7gD-5k1zA:
undetectable		 3e7gC-5k1zA:
21.98
3e7gD-5k1zA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m15 SYNTHETIC NANOBODY
L2_D09, (A-MBP#3)

(synthetic
construct) 		no annotation 4 ILE C 108
TRP C 110
PHE C  37
GLU C  44
 None
 1.36A 3e7gC-5m15C:
undetectable
3e7gD-5m15C:
undetectable		 3e7gC-5m15C:
14.90
3e7gD-5m15C:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 4 ARG A 417
ILE A 546
TRP A 587
PHE A 606
 None
 1.48A 3e7gC-5m6gA:
undetectable
3e7gD-5m6gA:
undetectable		 3e7gC-5m6gA:
21.72
3e7gD-5m6gA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		4 ARG A  84
TRP A  73
PHE A 318
GLU A 317
 None
 1.46A 3e7gC-5m7rA:
undetectable
3e7gD-5m7rA:
undetectable		 3e7gC-5m7rA:
18.14
3e7gD-5m7rA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.01A 3e7gC-5m8tA:
0.0
3e7gD-5m8tA:
0.0		 3e7gC-5m8tA:
20.93
3e7gD-5m8tA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus) 		no annotation 4 ARG A 249
ILE A 179
PHE A 581
GLU A 576
 None
 1.17A 3e7gC-5no8A:
undetectable
3e7gD-5no8A:
undetectable		 3e7gC-5no8A:
20.49
3e7gD-5no8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 ILE A 232
TRP A 251
PHE A 247
GLU A 227
 None
 1.15A 3e7gC-5nqdA:
undetectable
3e7gD-5nqdA:
undetectable		 3e7gC-5nqdA:
10.70
3e7gD-5nqdA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE

(Aspergillus
fumigatus) 		no annotation 4 ARG A1115
ILE A1136
PHE A1106
GLU A1090
 None
 1.30A 3e7gC-5o51A:
undetectable
3e7gD-5o51A:
undetectable		 3e7gC-5o51A:
11.14
3e7gD-5o51A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		4 MET A 519
ARG A  74
ILE A 510
GLU A 520
 None
 1.41A 3e7gC-5odrA:
undetectable
3e7gD-5odrA:
undetectable		 3e7gC-5odrA:
21.23
3e7gD-5odrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 4 MET A 224
ILE A 239
TRP A 226
GLU A 521
 None
 1.43A 3e7gC-5opqA:
undetectable
3e7gD-5opqA:
undetectable		 3e7gC-5opqA:
11.03
3e7gD-5opqA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3u PTS SYSTEM, IIA
COMPONENT

(Streptococcus
pneumoniae) 		PF03610
(EIIA-man) 		4 MET A  23
ILE A 102
PHE A  28
GLU A  26
 None
 1.19A 3e7gC-5t3uA:
undetectable
3e7gD-5t3uA:
undetectable		 3e7gC-5t3uA:
16.98
3e7gD-5t3uA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1

(Homo sapiens) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF08412
(Ion_trans_N) 		4 ILE A 278
TRP A 281
PHE A 285
GLU A 283
 None
 1.36A 3e7gC-5u6oA:
undetectable
3e7gD-5u6oA:
undetectable		 3e7gC-5u6oA:
19.32
3e7gD-5u6oA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1

(Homo sapiens) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF08412
(Ion_trans_N) 		4 ILE A 284
TRP A 281
PHE A 143
GLU A 282
 None
 1.49A 3e7gC-5u6oA:
undetectable
3e7gD-5u6oA:
undetectable		 3e7gC-5u6oA:
19.32
3e7gD-5u6oA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3h URACIL-DNA
GLYCOSYLASE

(Nitratifractor
salsuginis) 		no annotation 4 ILE A  30
TRP A  27
PHE A  63
GLU A  28
 None
 1.20A 3e7gC-5x3hA:
undetectable
3e7gD-5x3hA:
undetectable		 3e7gC-5x3hA:
22.06
3e7gD-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2p -

(-) 		no annotation 4 ARG A  30
ILE A 236
PHE A 264
GLU A 262
 None
 1.05A 3e7gC-5y2pA:
undetectable
3e7gD-5y2pA:
undetectable		 3e7gC-5y2pA:
undetectable
3e7gD-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM

(Geobacillus
stearothermophilus) 		no annotation 4 ILE A   3
TRP A  87
PHE A 145
GLU A  85
 None
 0.80A 3e7gC-5yhhA:
undetectable
3e7gD-5yhhA:
undetectable		 3e7gC-5yhhA:
11.33
3e7gD-5yhhA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zib -

(-) 		no annotation 4 ARG A 500
ILE A 437
PHE A 504
GLU A 442
 NAG  A1001 ( 4.0A)
None
None
None
 1.32A 3e7gC-5zibA:
undetectable
3e7gD-5zibA:
undetectable		 3e7gC-5zibA:
undetectable
3e7gD-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A

(Homo sapiens) 		no annotation 4 MET A1807
ILE A1805
PHE A1889
GLU A1810
 None
 1.24A 3e7gC-6fghA:
undetectable
3e7gD-6fghA:
undetectable		 3e7gC-6fghA:
14.24
3e7gD-6fghA:
14.24