SIMILAR PATTERNS OF AMINO ACIDS FOR 3E6T_B_H4BB902

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a80 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE A

(Corynebacterium
sp.) 		PF00248
(Aldo_ket_red) 		3 ARG A 171
ILE A 255
TRP A 221
 None
 1.02A 3e6tB-1a80A:
0.0		 3e6tB-1a80A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0z PROTEIN
(PHOSPHOGLUCOSE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00342
(PGI) 		3 ARG A  36
ILE A 199
TRP A  46
 None
 0.94A 3e6tB-1b0zA:
0.0		 3e6tB-1b0zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE

(Escherichia
virus Lambda) 		PF00149
(Metallophos) 		3 ARG A 162
ILE A 159
TRP A 160
 SO4  A3001 (-3.3A)
None
None
 0.87A 3e6tB-1g5bA:
0.0		 3e6tB-1g5bA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iiw SLR1257 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00497
(SBP_bac_3) 		3 ARG A  36
ILE A  30
TRP A 224
 None
 1.20A 3e6tB-1iiwA:
0.0		 3e6tB-1iiwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqg CARBOXYPEPTIDASE A

(Helicoverpa
armigera) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		3 ARG A 302
ILE A 100
TRP A 105
 None
 1.19A 3e6tB-1jqgA:
0.0		 3e6tB-1jqgA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		3 ARG A  67
ILE A 107
TRP A 136
 HEC  A 802 (-4.2A)
None
None
 1.07A 3e6tB-1kb0A:
0.0		 3e6tB-1kb0A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF09291
(DUF1968) 		3 ARG D 129
ILE E 138
TRP E 204
 None
 1.07A 3e6tB-1mi5D:
undetectable		 3e6tB-1mi5D:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrk YGFZ PROTEIN

(Escherichia
coli) 		PF01571
(GCV_T) 		3 ARG A 160
ILE A  85
TRP A  27
 None
SO4  A 400 ( 4.7A)
SO4  A 400 (-3.4A)
 1.12A 3e6tB-1nrkA:
0.0		 3e6tB-1nrkA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		3 ARG A 371
ILE A 388
TRP A 392
 None
 1.21A 3e6tB-1oltA:
undetectable		 3e6tB-1oltA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p22 F-BOX/WD-REPEAT
PROTEIN 1A

(Homo sapiens) 		PF00400
(WD40)
PF12937
(F-box-like) 		3 ARG A 384
ILE A 403
TRP A 415
 None
 1.16A 3e6tB-1p22A:
undetectable		 3e6tB-1p22A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 ARG A 609
ILE A 351
TRP A 362
 None
 1.10A 3e6tB-1pguA:
undetectable		 3e6tB-1pguA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL

(Homo sapiens) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ARG A 125
ILE A 222
TRP A 223
 PO4  A 400 (-3.4A)
None
None
 0.95A 3e6tB-1qk1A:
undetectable		 3e6tB-1qk1A:
22.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		3 ARG A 375
ILE A 456
TRP A 457
 H4B  A 901 (-3.4A)
H4B  A 901 (-4.7A)
H4B  A 901 ( 3.7A)
 0.19A 3e6tB-1qw5A:
60.4		 3e6tB-1qw5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		3 ARG A 227
ILE A 222
TRP A 230
 None
 1.09A 3e6tB-1rk2A:
undetectable		 3e6tB-1rk2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		3 ARG B 776
ILE B 816
TRP B 817
 None
 1.03A 3e6tB-1uw4B:
undetectable		 3e6tB-1uw4B:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		3 ARG C 582
ILE C 573
TRP C 574
 None
 1.05A 3e6tB-1w36C:
undetectable		 3e6tB-1w36C:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Sulfurisphaera
tokodaii) 		PF00908
(dTDP_sugar_isom) 		3 ARG A  40
ILE A  13
TRP A 111
 None
 0.95A 3e6tB-1wltA:
undetectable		 3e6tB-1wltA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wms RAS-RELATED PROTEIN
RAB-9A

(Homo sapiens) 		PF00071
(Ras) 		3 ARG A  78
ILE A  11
TRP A  61
 None
 1.21A 3e6tB-1wmsA:
undetectable		 3e6tB-1wmsA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		3 ARG A 207
ILE A  18
TRP A 493
 None
FAD  A 803 (-4.7A)
None
 1.09A 3e6tB-1yy5A:
undetectable		 3e6tB-1yy5A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z06 RAS-RELATED PROTEIN
RAB-33B

(Mus musculus) 		PF00071
(Ras) 		3 ARG A 105
ILE A  37
TRP A  87
 None
 1.20A 3e6tB-1z06A:
undetectable		 3e6tB-1z06A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 ARG A 178
ILE A 212
TRP A 271
 None
 1.01A 3e6tB-1z1wA:
undetectable		 3e6tB-1z1wA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayu NUCLEOSOME ASSEMBLY
PROTEIN

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		3 ARG A 355
ILE A 131
TRP A 132
 None
 1.02A 3e6tB-2ayuA:
undetectable		 3e6tB-2ayuA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF01156
(IU_nuc_hydro) 		3 ARG A 156
ILE A 194
TRP A 246
 None
 1.00A 3e6tB-2c40A:
undetectable		 3e6tB-2c40A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		3 ARG A 414
ILE A 406
TRP A 408
 None
 0.89A 3e6tB-2fknA:
undetectable		 3e6tB-2fknA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE

(Mycoplasma
mycoides) 		PF01712
(dNK) 		3 ARG A 145
ILE A 139
TRP A 158
 DCP  A1202 (-2.8A)
None
None
 0.94A 3e6tB-2jaqA:
undetectable		 3e6tB-2jaqA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pes URICASE

(Aspergillus
flavus) 		PF01014
(Uricase) 		3 ARG A 128
ILE A 142
TRP A 188
 None
 0.95A 3e6tB-2pesA:
undetectable		 3e6tB-2pesA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pig PUTATIVE TRANSFERASE

(Salmonella
enterica) 		no annotation 3 ARG A 131
ILE A  98
TRP A  97
 None
 1.07A 3e6tB-2pigA:
undetectable		 3e6tB-2pigA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		3 ARG A 293
ILE A  70
TRP A  24
 None
 0.88A 3e6tB-2qi2A:
undetectable		 3e6tB-2qi2A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		3 ARG A 418
ILE A 410
TRP A 412
 None
 0.84A 3e6tB-2v7gA:
undetectable		 3e6tB-2v7gA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w45 ALKALINE EXONUCLEASE

(Human
gammaherpesvirus
4) 		PF01771
(Herpes_alk_exo) 		3 ARG A  45
ILE A 127
TRP A 444
 None
 1.19A 3e6tB-2w45A:
undetectable		 3e6tB-2w45A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xlr FLAVIN-CONTAINING
MONOOXYGENASE

(Methylophaga
aminisulfidivorans) 		PF00743
(FMO-like) 		3 ARG A 122
ILE A 112
TRP A 109
 None
 1.20A 3e6tB-2xlrA:
undetectable		 3e6tB-2xlrA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1k (NEO)PULLULANASE

(Thermus
thermophilus) 		PF00128
(Alpha-amylase) 		3 ARG A 200
ILE A 233
TRP A 234
 GLC  A 603 (-3.4A)
None
GLC  A 501 (-3.4A)
 1.20A 3e6tB-2z1kA:
undetectable		 3e6tB-2z1kA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2r NUCLEOSOME ASSEMBLY
PROTEIN

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		3 ARG A 355
ILE A 131
TRP A 132
 None
 1.16A 3e6tB-2z2rA:
undetectable		 3e6tB-2z2rA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdq STEROL CARRIER
PROTEIN 2-LIKE 2

(Aedes aegypti) 		PF02036
(SCP2) 		3 ARG A   0
ILE A  33
TRP A  42
 None
 1.08A 3e6tB-3bdqA:
undetectable		 3e6tB-3bdqA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		no annotation 3 ARG A 169
ILE A 217
TRP A 140
 None
 1.06A 3e6tB-3cjiA:
undetectable		 3e6tB-3cjiA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfr DIHYDROFOLATE
REDUCTASE

(Lactobacillus
casei) 		PF00186
(DHFR_1) 		3 ARG A 117
ILE A  13
TRP A   5
 None
NDP  A 163 (-3.8A)
None
 0.96A 3e6tB-3dfrA:
undetectable		 3e6tB-3dfrA:
16.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		3 ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.13A 3e6tB-3e7gA:
58.9		 3e6tB-3e7gA:
87.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 ARG A 485
ILE A 290
TRP A 333
 None
 0.89A 3e6tB-3gbdA:
undetectable		 3e6tB-3gbdA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)

(Rattus
norvegicus) 		PF07686
(V-set) 		3 ARG B 164
ILE B 148
TRP B 147
 None
 1.11A 3e6tB-3iy7B:
undetectable		 3e6tB-3iy7B:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j81 US2

(Kluyveromyces
lactis) 		PF00318
(Ribosomal_S2) 		3 ARG A 183
ILE A  57
TRP A  54
 None
 1.16A 3e6tB-3j81A:
undetectable		 3e6tB-3j81A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq3 LOMBRICINE KINASE

(Urechis caupo) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ARG A 117
ILE A 214
TRP A 215
 ADP  A 400 (-2.6A)
None
None
 0.80A 3e6tB-3jq3A:
undetectable		 3e6tB-3jq3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6m RPFF PROTEIN

(Xanthomonas
campestris) 		PF00378
(ECH_1) 		3 ARG A  24
ILE A  19
TRP A  28
 None
 0.99A 3e6tB-3m6mA:
undetectable		 3e6tB-3m6mA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		3 ARG A 230
ILE A 237
TRP A 265
 SO4  A 996 (-4.3A)
None
None
 1.17A 3e6tB-3opyA:
undetectable		 3e6tB-3opyA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		3 ARG A 204
ILE A 219
TRP A 218
 None
 1.16A 3e6tB-3p27A:
undetectable		 3e6tB-3p27A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 ARG A 749
ILE A 685
TRP A 689
 None
 0.88A 3e6tB-3s9vA:
undetectable		 3e6tB-3s9vA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ARG A 122
ILE A 455
TRP A 457
 None
CU  A 501 (-3.8A)
None
 0.81A 3e6tB-3t6wA:
undetectable		 3e6tB-3t6wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 420
ILE A 233
TRP A  87
 None
 1.12A 3e6tB-3tiaA:
undetectable		 3e6tB-3tiaA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw5 TRANSGLUTAMINASE
ELICITOR

(Phytophthora
sojae) 		PF16683
(TGase_elicitor) 		3 ARG A 438
ILE A 442
TRP A 441
 None
 1.01A 3e6tB-3tw5A:
undetectable		 3e6tB-3tw5A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upu ATP-DEPENDENT DNA
HELICASE DDA

(Escherichia
virus T4) 		PF13604
(AAA_30) 		3 ARG A 253
ILE A 342
TRP A 323
 None
 1.14A 3e6tB-3upuA:
undetectable		 3e6tB-3upuA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 3 ARG A 385
ILE A 406
TRP A 411
 None
 0.77A 3e6tB-3w36A:
undetectable		 3e6tB-3w36A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN

(Caenorhabditis
elegans) 		no annotation 3 ARG A 145
ILE A  62
TRP A  61
 None
 1.18A 3e6tB-3zheA:
undetectable		 3e6tB-3zheA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awl NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT GAMMA

(Homo sapiens) 		PF00808
(CBFD_NFYB_HMF) 		3 ARG C  93
ILE C  86
TRP C  85
 None
 1.18A 3e6tB-4awlC:
undetectable		 3e6tB-4awlC:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 ARG B2628
ILE B2508
TRP B2593
 None
 1.04A 3e6tB-4bedB:
undetectable		 3e6tB-4bedB:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		3 ARG V 926
ILE V 961
TRP V 939
 None
 1.13A 3e6tB-4bxsV:
undetectable		 3e6tB-4bxsV:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Neurospora
crassa) 		no annotation 3 ARG A 104
ILE A  64
TRP B 566
 PO4  A 401 (-4.0A)
None
None
 1.05A 3e6tB-4czxA:
undetectable		 3e6tB-4czxA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ARG A 931
ILE A 859
TRP A 885
 None
 1.15A 3e6tB-4ddwA:
undetectable		 3e6tB-4ddwA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcy TRANSPOSASE

(Escherichia
virus Mu) 		PF02316
(HTH_Tnp_Mu_1)
PF02914
(DDE_2)
PF09039
(HTH_Tnp_Mu_2)
PF09299
(Mu-transpos_C) 		3 ARG A 298
ILE A 266
TRP A 265
 None
 1.19A 3e6tB-4fcyA:
undetectable		 3e6tB-4fcyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 420
ILE A 233
TRP A  87
 None
 1.12A 3e6tB-4h53A:
undetectable		 3e6tB-4h53A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2k TRYPSIN INHIBITOR

(Enterolobium
contortisiliquum) 		PF00197
(Kunitz_legume) 		3 ARG A  64
ILE A  58
TRP A  60
 None
 1.20A 3e6tB-4j2kA:
undetectable		 3e6tB-4j2kA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh8 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF16103
(DUF4822) 		3 ARG A 190
ILE A  89
TRP A  65
 None
 1.10A 3e6tB-4kh8A:
undetectable		 3e6tB-4kh8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ARG A 129
ILE A 936
TRP A 935
 None
 1.19A 3e6tB-4mz0A:
undetectable		 3e6tB-4mz0A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rev DISEASE RESISTANCE
RESPONSE PROTEIN 206

(Pisum sativum) 		PF03018
(Dirigent) 		3 ARG A 141
ILE A 102
TRP A 112
 None
 1.13A 3e6tB-4revA:
undetectable		 3e6tB-4revA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsk KETOL-ACID
REDUCTOISOMERASE

(Alicyclobacillus
acidocaldarius) 		PF01450
(IlvC)
PF07991
(IlvN) 		3 ARG A  84
ILE A 291
TRP A 290
 None
 1.08A 3e6tB-4tskA:
undetectable		 3e6tB-4tskA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb3 NUDIX HYDROLASE 7

(Arabidopsis
thaliana) 		PF00293
(NUDIX) 		3 ARG A  74
ILE A  53
TRP A  54
 None
 1.05A 3e6tB-4zb3A:
undetectable		 3e6tB-4zb3A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		3 ARG B  24
ILE B 168
TRP B 169
 None
 1.13A 3e6tB-4zktB:
undetectable		 3e6tB-4zktB:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 ARG A1164
ILE A1161
TRP A1134
 None
 0.79A 3e6tB-4zxiA:
undetectable		 3e6tB-4zxiA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 ARG A1164
ILE A1298
TRP A1134
 None
 0.96A 3e6tB-4zxiA:
undetectable		 3e6tB-4zxiA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 ARG A 362
ILE A 454
TRP A 458
 None
 1.15A 3e6tB-5a0zA:
undetectable		 3e6tB-5a0zA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 3 ARG A 227
ILE A 163
TRP A 423
 None
 1.10A 3e6tB-5c2vA:
undetectable		 3e6tB-5c2vA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1

(Homo sapiens) 		PF02137
(A_deamin) 		3 ARG A 405
ILE A 609
TRP A 602
 None
 1.19A 3e6tB-5ed1A:
undetectable		 3e6tB-5ed1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ARG A 121
ILE A 453
TRP A 455
 None
CU  A 510 (-3.7A)
None
 0.85A 3e6tB-5ehfA:
undetectable		 3e6tB-5ehfA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2v GTP
PYROPHOSPHOKINASE
YJBM

(Bacillus
subtilis) 		no annotation 3 ARG V 143
ILE V 153
TRP V 150
 APC  V 301 ( 4.9A)
None
None
 0.97A 3e6tB-5f2vV:
undetectable		 3e6tB-5f2vV:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		3 ARG C 114
ILE C 119
TRP C  93
 None
 0.95A 3e6tB-5flzC:
undetectable		 3e6tB-5flzC:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A

(Homo sapiens) 		PF06105
(Aph-1) 		3 ARG C 186
ILE C 230
TRP C 227
 None
 1.11A 3e6tB-5fn4C:
undetectable		 3e6tB-5fn4C:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsy MACRODOMAIN

(Trypanosoma
brucei) 		PF01661
(Macro) 		3 ARG A 169
ILE A  57
TRP A  76
 None
 1.07A 3e6tB-5fsyA:
undetectable		 3e6tB-5fsyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		3 ARG A1190
ILE A1187
TRP A1176
 None
 1.12A 3e6tB-5gzuA:
undetectable		 3e6tB-5gzuA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh9 PVDN

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		3 ARG A 102
ILE A  94
TRP A  95
 None
 1.16A 3e6tB-5hh9A:
undetectable		 3e6tB-5hh9A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibv CAPSID POLYPROTEIN
VP90

(Mamastrovirus 1) 		PF03115
(Astro_capsid_N) 		3 ARG A 179
ILE A 102
TRP A 350
 None
 1.00A 3e6tB-5ibvA:
undetectable		 3e6tB-5ibvA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 ARG A 623
ILE A 659
TRP A 656
 None
 1.03A 3e6tB-5ja1A:
undetectable		 3e6tB-5ja1A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3z POLYKETIDE
KETOREDUCTASE SIMC7

(Streptomyces
antibioticus) 		PF13460
(NAD_binding_10) 		3 ARG A 130
ILE A 119
TRP A 126
 None
 1.18A 3e6tB-5l3zA:
undetectable		 3e6tB-5l3zA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ARG A 122
ILE A 455
TRP A 457
 None
CU  A 504 (-3.8A)
None
 0.85A 3e6tB-5mewA:
undetectable		 3e6tB-5mewA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 3 ARG A  97
ILE A  22
TRP A  23
 None
 1.06A 3e6tB-5mqpA:
undetectable		 3e6tB-5mqpA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n77 MAGNESIUM TRANSPORT
PROTEIN CORA

(Escherichia
coli) 		PF01544
(CorA) 		3 ARG A  14
ILE A  29
TRP A  28
 None
 1.17A 3e6tB-5n77A:
undetectable		 3e6tB-5n77A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojr -

(-) 		no annotation 3 ARG A  82
ILE A  64
TRP A  70
 None
 1.10A 3e6tB-5ojrA:
undetectable		 3e6tB-5ojrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqj RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 1

(Saccharomyces
cerevisiae) 		no annotation 3 ARG 1  30
ILE 1  16
TRP 1  29
 None
 1.05A 3e6tB-5oqj1:
undetectable		 3e6tB-5oqj1:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqm GENERAL
TRANSCRIPTION AND
DNA REPAIR FACTOR
IIH SUBUNIT TFB1

(Saccharomyces
cerevisiae) 		no annotation 3 ARG 1  30
ILE 1  16
TRP 1  29
 None
 1.03A 3e6tB-5oqm1:
undetectable		 3e6tB-5oqm1:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 3 ARG A 501
ILE A 535
TRP A 536
 None
 1.19A 3e6tB-5ot1A:
undetectable		 3e6tB-5ot1A:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT

(Homo sapiens) 		PF05063
(MT-A70) 		3 ARG A 508
ILE A 503
TRP A 457
 None
 1.02A 3e6tB-5teyA:
undetectable		 3e6tB-5teyA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1

(Homo sapiens) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF08412
(Ion_trans_N) 		3 ARG A 267
ILE A 176
TRP A 175
 None
 1.01A 3e6tB-5u6oA:
undetectable		 3e6tB-5u6oA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 3 ARG A 721
ILE A 514
TRP A 505
 None
 1.19A 3e6tB-5wmmA:
undetectable		 3e6tB-5wmmA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9d ACYL-COENZYME A
OXIDASE 1

(Yarrowia
lipolytica) 		no annotation 3 ARG A 242
ILE A 412
TRP A 437
 None
 1.21A 3e6tB-5y9dA:
0.0		 3e6tB-5y9dA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygh CAPSID PROTEIN

(Zika virus) 		no annotation 3 ARG A  55
ILE A  66
TRP A  69
 None
 1.00A 3e6tB-5yghA:
undetectable		 3e6tB-5yghA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys9 ACYL-COENZYME A
OXIDASE 3

(Yarrowia
lipolytica) 		no annotation 3 ARG A 256
ILE A 423
TRP A 448
 None
 1.18A 3e6tB-5ys9A:
0.0		 3e6tB-5ys9A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN

(Escherichia
coli) 		no annotation 3 ARG A 402
ILE A 413
TRP A 416
 None
 1.15A 3e6tB-5z0rA:
undetectable		 3e6tB-5z0rA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 3 ARG A 142
ILE A 114
TRP A 117
 None
 1.17A 3e6tB-5z5dA:
undetectable		 3e6tB-5z5dA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0t FASCIN

(Homo sapiens) 		no annotation 3 ARG A 224
ILE A  93
TRP A 101
 None
C7V  A 501 ( 4.2A)
C7V  A 501 (-3.2A)
 1.13A 3e6tB-6b0tA:
undetectable		 3e6tB-6b0tA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br6 NEURAMINIDASE

(Influenza A
virus) 		no annotation 3 ARG A 420
ILE A 233
TRP A  87
 None
 1.08A 3e6tB-6br6A:
undetectable		 3e6tB-6br6A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7v -

(-) 		no annotation 3 ARG A 202
ILE A  11
TRP A  50
 None
 1.10A 3e6tB-6c7vA:
undetectable		 3e6tB-6c7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2q FERM, RHOGEF
(ARHGEF) AND
PLECKSTRIN DOMAIN
PROTEIN 1
(CHONDROCYTE-DERIVED
)

(Danio rerio) 		no annotation 3 ARG A 149
ILE A 310
TRP A  95
 None
 1.14A 3e6tB-6d2qA:
undetectable		 3e6tB-6d2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN

(Homo sapiens) 		no annotation 3 ARG A 338
ILE A 498
TRP A 341
 None
 0.91A 3e6tB-6ei1A:
undetectable		 3e6tB-6ei1A:
11.46