SIMILAR PATTERNS OF AMINO ACIDS FOR 3E67_A_H4BA902

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1lzx	NITRIC-OXIDE SYNTHASE (Rattus norvegicus)	PF02898 (NO_synthase)	4	SER A 334 MET A 336 ARG A 596 TRP A 678	None H4B A 760 ( 3.8A) H4B A 760 (-3.5A) H4B A 760 ( 3.6A)	0.49A	3e67A-1lzxA: 56.9	3e67A-1lzxA: 62.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1qw5	NITRIC OXIDE SYNTHASE, INDUCIBLE (Mus musculus)	PF02898 (NO_synthase)	5	SER A 112 MET A 114 ARG A 375 ILE A 456 TRP A 457	H4B A 901 (-4.8A) H4B A 901 (-4.0A) H4B A 901 (-3.4A) H4B A 901 (-4.7A) H4B A 901 ( 3.7A)	0.30A	3e67A-1qw5A: 62.2	3e67A-1qw5A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3e7g	NITRIC OXIDE SYNTHASE, INDUCIBLE (Homo sapiens)	PF02898 (NO_synthase)	5	SER A 118 MET A 120 ARG A 381 ILE A 462 TRP A 463	None H4B A 902 (-3.8A) H4B A 902 (-3.9A) H4B A 902 (-4.9A) H4B A 902 ( 3.6A)	0.50A	3e67A-3e7gA: 60.2	3e67A-3e7gA: 87.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5alc	ANTI-TICAGRELOR FAB 72, HEAVY CHAIN (Homo sapiens)	PF07654 (C1-set) PF07686 (V-set)	4	SER H 59 MET H 48 ILE H 69 TRP H 36	None	1.09A	3e67A-5alcH: 0.0	3e67A-5alcH: 17.43

[["3E67_A_H4BA902_1","1lzx","Rattus norvegicus","NITRIC-OXIDE SYNTHASE","PF02898(NO_synthase)",4,"SER A 334;MET A 336;ARG A 596;TRP A 678","None;H4B A 760 ( 3.8A);H4B A 760 (-3.5A);H4B A 760 ( 3.6A)","0.49A","3e67A-1lzxA:56.9","3e67A-1lzxA:62.88"],["3E67_A_H4BA902_1","1qw5","Mus musculus","NITRIC OXIDE SYNTHASE, INDUCIBLE","PF02898(NO_synthase)",5,"SER A 112;MET A 114;ARG A 375;ILE A 456;TRP A 457","H4B A 901 (-4.8A);H4B A 901 (-4.0A);H4B A 901 (-3.4A);H4B A 901 (-4.7A);H4B A 901 ( 3.7A)","0.30A","3e67A-1qw5A:62.2","3e67A-1qw5A:100.00"],["3E67_A_H4BA902_1","3e7g","Homo sapiens","NITRIC OXIDE SYNTHASE, INDUCIBLE","PF02898(NO_synthase)",5,"SER A 118;MET A 120;ARG A 381;ILE A 462;TRP A 463","None;H4B A 902 (-3.8A);H4B A 902 (-3.9A);H4B A 902 (-4.9A);H4B A 902 ( 3.6A)","0.50A","3e67A-3e7gA:60.2","3e67A-3e7gA:87.23"],["3E67_A_H4BA902_1","5alc","Homo sapiens","ANTI-TICAGRELOR FAB 72, HEAVY CHAIN","PF07654(C1-set);PF07686(V-set)",4,"SER H  59;MET H  48;ILE H  69;TRP H  36","None","1.09A","3e67A-5alcH:0.0","3e67A-5alcH:17.43"]]