SIMILAR PATTERNS OF AMINO ACIDS FOR 3E23_A_SAMA221_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
12as ASPARAGINE
SYNTHETASE

(Escherichia
coli) 		PF03590
(AsnA) 		3 TYR A 218
ASP A 118
HIS A  71
 ASN  A 331 (-4.3A)
ASN  A 331 (-3.3A)
None
 0.73A 3e23A-12asA:
undetectable		 3e23A-12asA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE

(Arthrobacter
sp. 1C) 		PF02317
(Octopine_DH)
PF02558
(ApbA) 		3 TYR A 259
ASP A 238
HIS A 202
 None
 0.79A 3e23A-1bg6A:
4.5		 3e23A-1bg6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		3 TYR A 130
ASP A 175
HIS A  55
 None
None
FAD  A 801 ( 4.9A)
 0.88A 3e23A-1e1kA:
undetectable		 3e23A-1e1kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 TYR A 204
ASP A  35
HIS A  40
 None
 0.78A 3e23A-1eu1A:
undetectable		 3e23A-1eu1A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 TYR A 253
ASP A 210
HIS A 226
 None
PLP  A1201 (-2.7A)
None
 0.88A 3e23A-1fc4A:
undetectable		 3e23A-1fc4A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)

(Allochromatium
vinosum;
Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind)
no annotation 		3 TYR A 306
ASP A 398
HIS C  15
 None
None
HEM  C 901 (-3.3A)
 0.90A 3e23A-1fcdA:
undetectable		 3e23A-1fcdA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 TYR A 152
ASP A 178
HIS A 242
 None
PQQ  A 701 (-3.5A)
None
 0.95A 3e23A-1flgA:
undetectable		 3e23A-1flgA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 TYR A 797
ASP A 441
HIS A 195
 MGD  A5001 (-3.8A)
None
MGD  A5001 (-4.5A)
 0.91A 3e23A-1g8kA:
undetectable		 3e23A-1g8kA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 TYR A 977
ASP A 998
HIS A 950
 None
 0.95A 3e23A-1hwwA:
undetectable		 3e23A-1hwwA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		3 TYR A 132
ASP A 177
HIS A  57
 None
None
ACT  A1869 (-3.7A)
 0.91A 3e23A-1lqtA:
undetectable		 3e23A-1lqtA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		3 TYR A 326
ASP A 351
HIS A 397
 AMP  A 706 (-4.1A)
MG  A 604 (-2.7A)
None
 0.78A 3e23A-1mb9A:
2.8		 3e23A-1mb9A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnh ASPARAGINYL-TRNA
SYNTHETASE-RELATED
PEPTIDE

(Pyrococcus
furiosus) 		PF00152
(tRNA-synt_2) 		3 TYR A 194
ASP A 118
HIS A  74
 None
 0.92A 3e23A-1nnhA:
undetectable		 3e23A-1nnhA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt4 GLUCOSE-1-PHOSPHATAS
E

(Escherichia
coli) 		PF00328
(His_Phos_2) 		3 TYR A 268
ASP A 124
HIS A 115
 None
 0.68A 3e23A-1nt4A:
undetectable		 3e23A-1nt4A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
SMALL SUBUNIT

(Rhodococcus
jostii) 		PF00866
(Ring_hydroxyl_B) 		3 TYR B  55
ASP B 153
HIS B 111
 None
 0.71A 3e23A-1uliB:
undetectable		 3e23A-1uliB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		3 TYR A 550
ASP A 515
HIS A 539
 None
None
LBT  A1648 (-3.9A)
 0.87A 3e23A-1w8oA:
undetectable		 3e23A-1w8oA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas
fluorescens) 		PF00866
(Ring_hydroxyl_B) 		3 TYR B  54
ASP B 152
HIS B 110
 None
 0.72A 3e23A-1wqlB:
undetectable		 3e23A-1wqlB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		3 TYR A  64
ASP A   5
HIS A  19
 None
MG  A3001 (-3.2A)
None
 0.61A 3e23A-1x9sA:
undetectable		 3e23A-1x9sA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpn HYPOTHETICAL PROTEIN
PA1324

(Pseudomonas
aeruginosa) 		no annotation 3 TYR A 107
ASP A 101
HIS A  33
 None
 0.86A 3e23A-1xpnA:
undetectable		 3e23A-1xpnA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B

(Sulfolobus
shibatae) 		PF02518
(HATPase_c)
PF05833
(FbpA)
PF09239
(Topo-VIb_trans) 		3 TYR A 422
ASP A 386
HIS A 414
 None
 0.86A 3e23A-1z5aA:
undetectable		 3e23A-1z5aA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 TYR A 236
ASP A 190
HIS A 357
 None
 0.95A 3e23A-2akjA:
undetectable		 3e23A-2akjA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE SMALL
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00866
(Ring_hydroxyl_B) 		3 TYR B 551
ASP B 647
HIS B 604
 None
 0.75A 3e23A-2b24B:
undetectable		 3e23A-2b24B:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej5 ENOYL-COA HYDRATASE
SUBUNIT II

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		3 TYR A 147
ASP A 119
HIS A  94
 None
 0.90A 3e23A-2ej5A:
undetectable		 3e23A-2ej5A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcc ENDONUCLEASE V

(Escherichia
virus T4) 		PF03013
(Pyr_excise) 		3 TYR A 104
ASP A  62
HIS A  56
 SO4  A 501 (-4.8A)
None
None
 0.97A 3e23A-2fccA:
undetectable		 3e23A-2fccA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frv PERIPLASMIC
HYDROGENASE

(Desulfovibrio
gigas) 		no annotation 3 TYR L 268
ASP L 189
HIS L 179
 None
 0.79A 3e23A-2frvL:
undetectable		 3e23A-2frvL:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		3 TYR A 223
ASP A  59
HIS A 258
 None
None
ZN  A1000 (-3.2A)
 0.86A 3e23A-2gsnA:
undetectable		 3e23A-2gsnA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pso STAR-RELATED LIPID
TRANSFER PROTEIN 13

(Homo sapiens) 		PF01852
(START) 		3 TYR A 999
ASP A 978
HIS A1068
 None
 0.93A 3e23A-2psoA:
undetectable		 3e23A-2psoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqr PUTATIVE SULFATASE

(Rhizobium
leguminosarum) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 TYR A 290
ASP A  17
HIS A 325
 None
None
MN  A1515 ( 3.3A)
 0.95A 3e23A-2vqrA:
undetectable		 3e23A-2vqrA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 TYR A  31
ASP A  85
HIS A 141
 None
None
CL  A 401 (-4.1A)
 0.84A 3e23A-2w2jA:
undetectable		 3e23A-2w2jA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 TYR A 290
ASP A  17
HIS A 325
 None
None
ZN  A1515 ( 3.2A)
 0.92A 3e23A-2w8sA:
undetectable		 3e23A-2w8sA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 TYR A 390
ASP A 245
HIS A 233
 None
 0.90A 3e23A-2wd9A:
undetectable		 3e23A-2wd9A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		3 TYR A 383
ASP A 451
HIS A  45
 None
BR  A1482 ( 4.3A)
None
 0.97A 3e23A-2xhyA:
undetectable		 3e23A-2xhyA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		3 TYR A 109
ASP A 160
HIS A 206
 None
 0.65A 3e23A-2z7xA:
undetectable		 3e23A-2z7xA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE

(Shewanella sp.
AP1) 		PF00245
(Alk_phosphatase) 		3 TYR A  47
ASP A 366
HIS A 387
 None
 0.95A 3e23A-3a52A:
undetectable		 3e23A-3a52A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli) 		PF01343
(Peptidase_S49) 		3 TYR A 133
ASP A  69
HIS A 546
 None
 0.85A 3e23A-3bf0A:
undetectable		 3e23A-3bf0A:
16.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris) 		PF08241
(Methyltransf_11) 		3 TYR A  24
ASP A  72
HIS A 109
 SAM  A 221 (-4.7A)
SAM  A 221 (-2.8A)
SAM  A 221 ( 3.7A)
 0.00A 3e23A-3e23A:
41.5		 3e23A-3e23A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eby BETA SUBUNIT OF A
PUTATIVE
AROMATIC-RING-HYDROX
YLATING DIOXYGENASE

(Novosphingobium
aromaticivorans) 		PF00866
(Ring_hydroxyl_B) 		3 TYR A  44
ASP A 131
HIS A  89
 None
 0.88A 3e23A-3ebyA:
undetectable		 3e23A-3ebyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT BETA

(Pseudomonas
putida) 		PF00866
(Ring_hydroxyl_B) 		3 TYR B  55
ASP B 153
HIS B 111
 None
 0.74A 3e23A-3eqqB:
undetectable		 3e23A-3eqqB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE

(Xylella
fastidiosa) 		PF07221
(GlcNAc_2-epim) 		3 TYR A 342
ASP A  11
HIS A  21
 None
 0.88A 3e23A-3gt5A:
undetectable		 3e23A-3gt5A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Comamonas
testosteroni) 		PF00866
(Ring_hydroxyl_B) 		3 TYR B  54
ASP B 152
HIS B 110
 None
 0.69A 3e23A-3gzyB:
undetectable		 3e23A-3gzyB:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwc CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 2

(Burkholderia
cepacia) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		3 TYR A3036
ASP A3253
HIS A3105
 None
 0.81A 3e23A-3hwcA:
undetectable		 3e23A-3hwcA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 TYR A 177
ASP A 160
HIS A 146
 None
None
LLX  A 400 (-3.8A)
 0.85A 3e23A-3maxA:
3.4		 3e23A-3maxA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn8 LP15968P

(Drosophila
melanogaster) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 TYR A 283
ASP A 270
HIS A 217
 GEM  A 601 (-3.3A)
None
ZN  A 999 ( 3.2A)
 0.79A 3e23A-3mn8A:
undetectable		 3e23A-3mn8A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE

(Enterobacter
cloacae) 		PF00328
(His_Phos_2) 		3 TYR A 266
ASP A 122
HIS A 113
 None
 0.73A 3e23A-3ntlA:
undetectable		 3e23A-3ntlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN

(Pyrococcus
abyssi) 		PF00152
(tRNA-synt_2) 		3 TYR A 194
ASP A 118
HIS A  74
 None
 0.87A 3e23A-3p8tA:
undetectable		 3e23A-3p8tA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnd THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE

(Salmonella
enterica) 		PF02424
(ApbE) 		3 TYR A  78
ASP A 181
HIS A 270
 FAD  A 500 (-3.7A)
FAD  A 500 (-3.2A)
SO4  A 362 (-4.0A)
 0.89A 3e23A-3pndA:
undetectable		 3e23A-3pndA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk UREASE SUBUNIT BETA
2

(Helicobacter
mustelae) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 TYR C  38
ASP C  18
HIS C  33
 None
 0.96A 3e23A-3qgkC:
undetectable		 3e23A-3qgkC:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfg 3F8 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H  32
ASP H 101
HIS H  98
 None
 0.93A 3e23A-3vfgH:
undetectable		 3e23A-3vfgH:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
HEME SUBUNIT
FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum;
Thermochromatium
tepidum) 		no annotation
PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		3 TYR B 306
ASP B 398
HIS A  15
 None
None
HEC  A 201 (-3.2A)
 0.72A 3e23A-3vrdB:
1.8		 3e23A-3vrdB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		3 TYR A 211
ASP A 360
HIS A 363
 None
 0.93A 3e23A-3vtrA:
undetectable		 3e23A-3vtrA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a69 HISTONE DEACETYLASE
3,

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 TYR A 166
ASP A 149
HIS A 135
 None
None
ACT  A 501 (-3.7A)
 0.82A 3e23A-4a69A:
3.3		 3e23A-4a69A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		3 TYR A  30
ASP A 580
HIS A 587
 None
 0.88A 3e23A-4amfA:
undetectable		 3e23A-4amfA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bdu GREEN FLUORESCENT
PROTEIN, APOPTOSIS
REGULATOR BAX

(Aequorea
victoria;
Homo sapiens) 		PF00452
(Bcl-2)
PF01353
(GFP) 		3 TYR A 106
ASP A 103
HIS A 139
 None
 0.89A 3e23A-4bduA:
undetectable		 3e23A-4bduA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ber PHOSPHOCHOLINE
TRANSFERASE ANKX

(Legionella
pneumophila) 		PF02661
(Fic)
PF12796
(Ank_2) 		3 TYR A 431
ASP A 462
HIS A 176
 None
 0.81A 3e23A-4berA:
undetectable		 3e23A-4berA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx HISTONE DEACETYLASE
1

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 TYR B 172
ASP B 155
HIS B 141
 None
None
ACT  B 601 (-3.8A)
 0.81A 3e23A-4bkxB:
3.2		 3e23A-4bkxB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz7 HISTONE DEACETYLASE
8

(Schistosoma
mansoni) 		PF00850
(Hist_deacetyl) 		3 TYR A 182
ASP A 156
HIS A 142
 None
None
B3N  A 700 (-3.7A)
 0.90A 3e23A-4bz7A:
2.9		 3e23A-4bz7A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		3 TYR A 160
ASP A 117
HIS A 131
 None
 0.85A 3e23A-4c60A:
undetectable		 3e23A-4c60A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		3 TYR A 112
ASP A  30
HIS A 117
 CIT  A1589 (-4.6A)
None
CIT  A1589 (-4.3A)
 0.92A 3e23A-4conA:
undetectable		 3e23A-4conA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		3 TYR A 956
ASP A 949
HIS A 944
 None
 0.78A 3e23A-4gl9A:
undetectable		 3e23A-4gl9A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 TYR A 335
ASP A 115
HIS A 462
 None
None
PXM  A 609 (-3.8A)
 0.87A 3e23A-4ha6A:
2.1		 3e23A-4ha6A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 929
ASP A 922
HIS A 917
 None
 0.90A 3e23A-4hviA:
undetectable		 3e23A-4hviA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqb PROTEIN H03A11.1

(Caenorhabditis
elegans) 		PF06702
(Fam20C) 		3 TYR A 275
ASP A 366
HIS A 206
 None
MN  A 606 (-4.5A)
None
 0.84A 3e23A-4kqbA:
undetectable		 3e23A-4kqbA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Burkholderia
cenocepacia) 		PF01041
(DegT_DnrJ_EryC1) 		3 TYR A 324
ASP A 158
HIS A 184
 EDO  A 403 ( 4.0A)
EDO  A 403 (-3.6A)
CIT  A 401 (-4.0A)
 0.89A 3e23A-4lc3A:
1.9		 3e23A-4lc3A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mup AMIDOHYDROLASE

(Agrobacterium
fabrum) 		PF04909
(Amidohydro_2) 		3 TYR A 208
ASP A 255
HIS A  27
 None
 0.93A 3e23A-4mupA:
undetectable		 3e23A-4mupA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A

(Ustilago maydis) 		PF03664
(Glyco_hydro_62) 		3 TYR A 296
ASP A 258
HIS A 261
 None
None
CA  A 401 (-3.6A)
 0.88A 3e23A-4n2rA:
undetectable		 3e23A-4n2rA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nur PSDSA

(Pseudomonas sp.
S9) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 TYR A 246
ASP A 144
HIS A 194
 None
 0.91A 3e23A-4nurA:
undetectable		 3e23A-4nurA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8o ALPHA-L-ARABINOFURAN
OSIDASE

(Streptomyces
thermoviolaceus) 		PF03664
(Glyco_hydro_62) 		3 TYR A 349
ASP A 312
HIS A 315
 None
None
CA  A 401 ( 3.7A)
 0.90A 3e23A-4o8oA:
undetectable		 3e23A-4o8oA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		3 TYR A 184
ASP A 130
HIS A 164
 None
 0.88A 3e23A-4oraA:
undetectable		 3e23A-4oraA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS

(Escherichia
coli) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 TYR A 234
ASP A 132
HIS A 182
 None
None
SO4  A 701 (-4.0A)
 0.91A 3e23A-4pdxA:
undetectable		 3e23A-4pdxA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE

(Leishmania
major) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 TYR A 265
ASP A 260
HIS A 223
 None
 0.94A 3e23A-4qg5A:
undetectable		 3e23A-4qg5A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlj BETA-GLUCOSIDASE 7

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 TYR A 468
ASP A 403
HIS A 462
 CTT  A1002 (-3.8A)
None
None
 0.92A 3e23A-4qljA:
undetectable		 3e23A-4qljA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
fructosivorans) 		PF00374
(NiFeSe_Hases) 		3 TYR Q 277
ASP Q 198
HIS Q 188
 None
 0.83A 3e23A-4upeQ:
undetectable		 3e23A-4upeQ:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		3 TYR A 294
ASP A  18
HIS A 329
 None
None
ZN  A1576 (-3.1A)
 0.88A 3e23A-4upiA:
undetectable		 3e23A-4upiA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 TYR A 292
ASP A  14
HIS A 327
 None
None
ZN  A1553 (-3.2A)
 0.90A 3e23A-4uplA:
undetectable		 3e23A-4uplA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh3 N-ACETYLHEXOSAMINE
1-KINASE

(Bifidobacterium
longum) 		PF01636
(APH) 		3 TYR A 317
ASP A 158
HIS A 150
 None
 0.91A 3e23A-4wh3A:
undetectable		 3e23A-4wh3A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		3 TYR A  55
ASP A 113
HIS A 256
 FAD  A 401 (-4.0A)
None
FAD  A 401 (-3.4A)
 0.85A 3e23A-4xdtA:
undetectable		 3e23A-4xdtA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd6 HALOHYDRIN EPOXIDASE
B

(Corynebacterium
sp.) 		PF13561
(adh_short_C2) 		3 TYR A  19
ASP A 199
HIS A 162
 None
 0.92A 3e23A-4zd6A:
4.1		 3e23A-4zd6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 TYR A 196
ASP A 320
HIS A 161
 None
 0.92A 3e23A-5a05A:
4.2		 3e23A-5a05A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeu BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Paraburkholderia
xenovorans) 		PF00866
(Ring_hydroxyl_B) 		3 TYR B  56
ASP B 154
HIS B 112
 None
 0.71A 3e23A-5aeuB:
undetectable		 3e23A-5aeuB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		3 TYR A 200
ASP A 584
HIS A 545
 None
 0.95A 3e23A-5clwA:
undetectable		 3e23A-5clwA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czl GLUCANASE

(Raoultella
ornithinolytica) 		PF01270
(Glyco_hydro_8) 		3 TYR A 160
ASP A  97
HIS A  36
 None
 0.95A 3e23A-5czlA:
undetectable		 3e23A-5czlA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF03415
(Peptidase_C11) 		3 TYR A  77
ASP A  75
HIS A 135
 None
NA  A 401 ( 3.0A)
None
 0.87A 3e23A-5dynA:
undetectable		 3e23A-5dynA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy3 GLUCANASE

(Klebsiella
pneumoniae) 		PF01270
(Glyco_hydro_8) 		3 TYR A 175
ASP A 112
HIS A  51
 None
 0.90A 3e23A-5gy3A:
undetectable		 3e23A-5gy3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx0 UNCHARACTERIZED
PROTEIN DFER_1899

(Dyadobacter
fermentans) 		PF13088
(BNR_2) 		3 TYR A 381
ASP A 123
HIS A 309
 None
ACT  A 402 (-2.9A)
None
 0.91A 3e23A-5hx0A:
undetectable		 3e23A-5hx0A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1u NAD(P)H:FLAVIN
OXIDOREDUCTASE SYE4

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		3 TYR A 240
ASP A 190
HIS A 269
 TNF  A 402 (-4.5A)
None
None
 0.91A 3e23A-5k1uA:
undetectable		 3e23A-5k1uA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1

(Escherichia
coli) 		PF00884
(Sulfatase) 		3 TYR A 431
ASP A 251
HIS A 466
 None
None
ZN  A 601 (-3.1A)
 0.92A 3e23A-5k4pA:
undetectable		 3e23A-5k4pA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		3 TYR A  62
ASP A 315
HIS A 402
 None
 0.88A 3e23A-5karA:
undetectable		 3e23A-5karA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvh BACCELL_00856

(Bacteroides
cellulosilyticus) 		PF15892
(BNR_4) 		3 TYR A 232
ASP A 203
HIS A 302
 None
 0.87A 3e23A-5mvhA:
undetectable		 3e23A-5mvhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2

(Escherichia
coli) 		PF00884
(Sulfatase) 		3 TYR A 431
ASP A 251
HIS A 466
 None
None
ZN  A 602 (-3.1A)
 0.91A 3e23A-5mx9A:
2.1		 3e23A-5mx9A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80

(Chlamydomonas
reinhardtii) 		no annotation 3 TYR A 114
ASP A 193
HIS A 199
 GOL  A 802 ( 4.4A)
None
GOL  A 802 (-3.7A)
 0.97A 3e23A-5n4aA:
undetectable		 3e23A-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 3 TYR A 815
ASP A 471
HIS A 199
 MGD  A2001 (-3.4A)
None
MGD  A2001 (-4.5A)
 0.89A 3e23A-5nqdA:
undetectable		 3e23A-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 3 TYR A 386
ASP A 314
HIS A 344
 None
 0.83A 3e23A-5ot1A:
undetectable		 3e23A-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN

(Thermoactinomyces
vulgaris) 		PF00668
(Condensation) 		3 TYR A1017
ASP A1022
HIS A1169
 None
 0.84A 3e23A-5t3eA:
undetectable		 3e23A-5t3eA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		3 TYR A 322
ASP A  43
HIS A 353
 None
None
ZN  A 601 (-3.2A)
 0.89A 3e23A-5tj3A:
undetectable		 3e23A-5tj3A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00849
(PseudoU_synth_2) 		3 TYR A  99
ASP A  67
HIS A  64
 GOL  A 306 (-3.8A)
SO4  A 301 (-4.5A)
None
 0.97A 3e23A-5vbbA:
undetectable		 3e23A-5vbbA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi6 HISTONE DEACETYLASE
8

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 TYR A 174
ASP A 157
HIS A 143
 None
None
EDO  A 410 (-4.4A)
 0.89A 3e23A-5vi6A:
1.6		 3e23A-5vi6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd7 3,6-ANHYDRO-ALPHA-L-
GALACTONATE
CYCLOISOMERASE

(Vibrio sp. EJY3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A 201
ASP A 198
HIS A  29
 None
MG  A 402 (-2.9A)
None
 0.97A 3e23A-5xd7A:
2.4		 3e23A-5xd7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN

(Escherichia
coli) 		no annotation 3 TYR A 429
ASP A 249
HIS A 464
 None
None
ZN  A 601 (-3.2A)
 0.97A 3e23A-5xnuA:
2.1		 3e23A-5xnuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		3 TYR A 124
ASP A 176
HIS A 146
 None
 0.94A 3e23A-5y7oA:
undetectable		 3e23A-5y7oA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR

(Desulfovibrio
vulgaris;
Homo sapiens) 		no annotation 3 TYR A  77
ASP A  10
HIS A 275
 9ER  A1201 (-4.5A)
None
9ER  A1201 (-4.5A)
 0.84A 3e23A-5zkpA:
undetectable		 3e23A-5zkpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 3 TYR A 357
ASP A 425
HIS A 327
 FAD  A 501 (-4.3A)
None
FAD  A 501 (-4.5A)
 0.96A 3e23A-6bz0A:
2.9		 3e23A-6bz0A:
undetectable