SIMILAR PATTERNS OF AMINO ACIDS FOR 3E23_A_SAMA221_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef1 MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 LEU A 225
GLY A 202
GLY A 219
LEU A 218
PHE A 206
 None
 1.19A 3e23A-1ef1A:
undetectable		 3e23A-1ef1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0u PROTEASOME COMPONENT
PUP2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 LEU D 148
TYR D 160
GLY D  39
LEU D  48
HIS D 150
 None
 1.07A 3e23A-1g0uD:
undetectable		 3e23A-1g0uD:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 PHE A 407
GLY A 117
GLY A 203
SER A 205
LEU A 224
 None
SAF  A1998 (-3.1A)
None
None
None
 1.06A 3e23A-1gqrA:
undetectable		 3e23A-1gqrA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4r MERLIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 LEU A 241
GLY A 218
GLY A 235
LEU A 234
PHE A 222
 None
 1.20A 3e23A-1h4rA:
undetectable		 3e23A-1h4rA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 PRO A  57
GLY A 164
SER A 163
CYH A 103
HIS A 101
 None
 1.20A 3e23A-1jxkA:
undetectable		 3e23A-1jxkA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A  85
GLY A 224
SER A 223
LEU A 112
LEU A 258
 None
 1.03A 3e23A-1l8kA:
undetectable		 3e23A-1l8kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV

(Griffonia
simplicifolia) 		PF00139
(Lectin_legB) 		5 PHE A  78
LEU A  80
GLY A 222
GLY A  90
LEU A  91
 None
None
GAL  A 253 (-3.5A)
None
None
 1.09A 3e23A-1ledA:
undetectable		 3e23A-1ledA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oht CG14704 PROTEIN

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		5 TYR A  78
GLY A  81
GLY A  91
SER A  79
HIS A  67
 None
 1.10A 3e23A-1ohtA:
undetectable		 3e23A-1ohtA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		5 LEU A 391
PRO A 145
GLY A 482
GLY A 484
LEU A 335
 None
None
None
PO4  A3000 ( 3.8A)
None
 1.19A 3e23A-1qhbA:
undetectable		 3e23A-1qhbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2j PROTEIN FKBI

(Streptomyces
hygroscopicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 217
GLY A  89
GLY A 209
SER A 210
LEU A 207
 None
 1.10A 3e23A-1r2jA:
undetectable		 3e23A-1r2jA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 LEU A  71
GLY A 179
LEU A 182
LEU A 141
HIS A  75
 None
 1.19A 3e23A-1rtrA:
undetectable		 3e23A-1rtrA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slm STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 LEU A 245
GLY A  88
GLY A 208
LEU A 209
PHE A 210
 None
 0.92A 3e23A-1slmA:
undetectable		 3e23A-1slmA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vq0 33 KDA CHAPERONIN

(Thermotoga
maritima) 		PF01430
(HSP33) 		5 LEU A  62
GLY A  41
GLY A  46
LEU A  44
LEU A 140
 None
 1.06A 3e23A-1vq0A:
undetectable		 3e23A-1vq0A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yis ADENYLOSUCCINATE
LYASE

(Caenorhabditis
elegans) 		PF00206
(Lyase_1) 		5 LEU A 207
GLY A 196
GLY A 105
SER A 203
LEU A 104
 None
SO4  A1001 (-2.8A)
None
None
None
 1.17A 3e23A-1yisA:
undetectable		 3e23A-1yisA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 TYR A 111
GLY A 113
GLY A 105
SER A 106
LEU A 165
 None
 1.17A 3e23A-1yrwA:
3.9		 3e23A-1yrwA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz1 TRANSLATIONALLY
CONTROLLED TUMOR
PROTEIN

(Homo sapiens) 		PF00838
(TCTP) 		5 TYR A  18
GLY A  33
LEU A  29
PHE A 162
HIS A  76
 None
 1.10A 3e23A-1yz1A:
undetectable		 3e23A-1yz1A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 LEU A 181
TYR A 180
GLY A 139
GLY A 126
LEU A 150
 None
FAD  A 301 ( 4.7A)
None
None
None
 1.19A 3e23A-2culA:
3.5		 3e23A-2culA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		5 PHE A  62
GLY A 215
GLY A 360
LEU A 412
PHE A 411
 None
 1.16A 3e23A-2cy8A:
2.5		 3e23A-2cy8A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy3 ALANINE RACEMASE

(Corynebacterium
glutamicum) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 PRO A 224
GLY A 216
GLY A  58
LEU A  78
HIS A 158
 None
PLP  A 401 (-3.5A)
None
None
PLP  A 401 (-4.0A)
 1.18A 3e23A-2dy3A:
undetectable		 3e23A-2dy3A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgn PHOSPHOLIPASE C

(Bacillus cereus) 		PF00882
(Zn_dep_PLPC) 		5 LEU A 117
GLY A 114
SER A 116
LEU A  47
HIS A  14
 None
None
None
None
ZN  A 248 (-3.3A)
 1.19A 3e23A-2fgnA:
undetectable		 3e23A-2fgnA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 PRO A 315
GLY A 400
GLY A 403
LEU A 254
HIS A 584
 None
 1.11A 3e23A-2fjaA:
2.2		 3e23A-2fjaA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE

(Homo sapiens) 		PF00171
(Aldedh) 		5 PRO A 575
GLY A 498
SER A 497
LEU A 757
LEU A 377
 None
 1.12A 3e23A-2h5gA:
undetectable		 3e23A-2h5gA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
pneumoniae) 		PF01408
(GFO_IDH_MocA) 		5 LEU A 183
TYR A 184
GLY A 179
LEU A 175
HIS A 307
 None
 1.12A 3e23A-2ho5A:
4.2		 3e23A-2ho5A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kwo ZINC FINGER PROTEIN
DPF3

(Homo sapiens) 		PF00628
(PHD) 		5 GLY A 268
GLY A 291
SER A 290
LEU A 296
CYH A 265
 None
SAC  B   1 ( 4.9A)
None
SAC  B   1 ( 3.4A)
ZN  A 501 (-2.3A)
 1.09A 3e23A-2kwoA:
undetectable		 3e23A-2kwoA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		5 LEU A 255
PRO A 137
GLY A 129
GLY A 101
LEU A  95
 None
 1.04A 3e23A-2o1bA:
3.9		 3e23A-2o1bA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2g DIENELACTONE
HYDROLASE

(Trichormus
variabilis) 		PF01738
(DLH) 		5 PHE A 217
LEU A  64
GLY A  32
GLY A  35
LEU A 221
 None
 1.15A 3e23A-2o2gA:
3.1		 3e23A-2o2gA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqh PUTATIVE ISOMERASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TYR A 221
PRO A 129
GLY A 293
LEU A 292
HIS A 268
 None
 1.18A 3e23A-2oqhA:
undetectable		 3e23A-2oqhA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxx DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE

(Mycobacterium
tuberculosis) 		PF00692
(dUTPase) 		5 LEU A  36
GLY A 176
GLY A  82
LEU A  39
LEU A 130
 None
 1.15A 3e23A-2qxxA:
undetectable		 3e23A-2qxxA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN

(Homo sapiens) 		PF00782
(DSPc) 		5 LEU A 110
GLY A  56
GLY A  35
LEU A  36
HIS A  59
 None
 1.17A 3e23A-2r0bA:
undetectable		 3e23A-2r0bA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		5 LEU A 118
TYR A 115
GLY A 113
SER A 114
LEU A  88
 None
 1.19A 3e23A-2vlcA:
undetectable		 3e23A-2vlcA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vou 2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE

(Paenarthrobacter
nicotinovorans) 		PF00070
(Pyr_redox) 		5 LEU A  41
PRO A 164
GLY A 150
GLY A  13
SER A  14
 FAD  A1395 (-4.5A)
None
FAD  A1395 (-3.3A)
FAD  A1395 ( 4.7A)
FAD  A1395 (-2.8A)
 1.11A 3e23A-2vouA:
3.1		 3e23A-2vouA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 LEU A 478
GLY A 357
LEU A 353
LEU A 361
HIS A 587
 None
 1.13A 3e23A-2wpgA:
undetectable		 3e23A-2wpgA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Thermotoga
maritima) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 106
PRO A 347
GLY A 123
LEU A  99
LEU A 138
 None
 1.17A 3e23A-3a14A:
3.7		 3e23A-3a14A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A  83
GLY A 223
SER A 222
LEU A 110
LEU A 260
 None
 1.03A 3e23A-3a5kA:
undetectable		 3e23A-3a5kA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 TYR A 132
GLY A 164
LEU A 159
PHE A  83
CYH A 169
 None
 1.11A 3e23A-3au9A:
2.7		 3e23A-3au9A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 5 LEU A 626
GLY A 635
LEU A 636
LEU A 644
CYH A 578
 None
 1.13A 3e23A-3c2gA:
undetectable		 3e23A-3c2gA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c87 ENTEROCHELIN
ESTERASE

(Shigella
flexneri) 		PF00756
(Esterase)
PF11806
(DUF3327) 		5 LEU A 378
PRO A 346
GLY A  55
GLY A  89
SER A  90
 None
 1.12A 3e23A-3c87A:
undetectable		 3e23A-3c87A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE

(Methanosarcina
mazei) 		PF01933
(UPF0052) 		5 LEU A  13
PRO A  45
GLY A   6
GLY A 190
LEU A 188
 None
 1.19A 3e23A-3cgwA:
undetectable		 3e23A-3cgwA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE

(Methanosarcina
mazei) 		PF01933
(UPF0052) 		5 LEU A  13
PRO A  45
GLY A   7
GLY A 190
LEU A 188
 None
 1.19A 3e23A-3cgwA:
undetectable		 3e23A-3cgwA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctk RRNA N-GLYCOSIDASE

(Bougainvillea
spectabilis) 		PF00161
(RIP) 		5 LEU A 117
TYR A 114
GLY A 112
SER A 113
LEU A  87
 None
 1.14A 3e23A-3ctkA:
undetectable		 3e23A-3ctkA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		5 LEU A 477
GLY A 356
LEU A 352
LEU A 360
HIS A 586
 None
 1.05A 3e23A-3czeA:
undetectable		 3e23A-3czeA:
17.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris) 		PF08241
(Methyltransf_11) 		12 PHE A   9
LEU A  14
TYR A  17
PRO A  29
GLY A  53
GLY A  73
SER A  74
LEU A  77
LEU A  93
PHE A  94
CYH A 111
HIS A 114
 None
SAM  A 221 (-4.4A)
SAM  A 221 (-3.8A)
SAM  A 221 (-4.1A)
SAM  A 221 (-3.2A)
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
SAM  A 221 (-4.3A)
SAM  A 221 (-4.0A)
SAM  A 221 (-3.3A)
SAM  A 221 (-4.8A)
SAM  A 221 (-4.3A)
 0.02A 3e23A-3e23A:
41.5		 3e23A-3e23A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 LEU A 145
PRO A 871
GLY A 806
GLY A  97
CYH A 139
 None
None
None
None
FES  A 908 ( 2.4A)
 1.01A 3e23A-3fahA:
undetectable		 3e23A-3fahA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hug RNA POLYMERASE SIGMA
FACTOR
PROBABLE CONSERVED
MEMBRANE PROTEIN

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF04545
(Sigma70_r4)
PF13490
(zf-HC2) 		5 TYR A 135
GLY B  37
GLY A 138
SER A 134
LEU B  36
 None
 1.19A 3e23A-3hugA:
undetectable		 3e23A-3hugA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1

(Pseudomonas
aeruginosa) 		PF05567
(Neisseria_PilC) 		5 LEU A 690
GLY A 758
GLY A 750
LEU A 752
LEU A 748
 None
 1.16A 3e23A-3hx6A:
undetectable		 3e23A-3hx6A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		5 PHE A1484
GLY A  21
GLY A1157
SER A1155
LEU A  17
 None
 0.83A 3e23A-3jroA:
undetectable		 3e23A-3jroA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kda CFTR INHIBITORY
FACTOR (CIF)

(Pseudomonas
aeruginosa) 		no annotation 5 PRO D 157
GLY D  64
LEU D 200
PHE D 203
HIS D 297
 None
 0.99A 3e23A-3kdaD:
2.2		 3e23A-3kdaD:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm6 STAGE V SPORULATION
PROTEIN AD

(Bacillus
subtilis) 		PF07451
(SpoVAD) 		5 LEU A 263
GLY A 202
GLY A 237
SER A 236
HIS A 258
 None
 1.15A 3e23A-3lm6A:
undetectable		 3e23A-3lm6A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqe CAPSID PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		5 LEU A 491
TYR A 492
GLY A 421
GLY A 495
LEU A 453
 None
 1.17A 3e23A-3lqeA:
undetectable		 3e23A-3lqeA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 LEU A 272
TYR A 275
GLY A 302
LEU A 306
HIS A 249
 None
LWY  A 427 ( 4.7A)
None
None
ZN  A 426 ( 3.8A)
 1.04A 3e23A-3n2cA:
undetectable		 3e23A-3n2cA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus) 		PF13649
(Methyltransf_25) 		5 LEU A  12
TYR A  15
GLY A  56
GLY A  76
SER A  77
 SAM  A 300 ( 3.9A)
SAM  A 300 ( 3.5A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-4.5A)
 0.77A 3e23A-3ou6A:
19.0		 3e23A-3ou6A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PRO A 195
GLY A 296
LEU A 297
LEU A 333
PHE A 267
 None
 1.18A 3e23A-3ppsA:
undetectable		 3e23A-3ppsA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE (INO1)

(Archaeoglobus
fulgidus) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 GLY A  32
SER A  35
LEU A  33
LEU A 384
PHE A 364
 None
 1.09A 3e23A-3qw2A:
2.3		 3e23A-3qw2A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us8 ISOCITRATE
DEHYDROGENASE [NADP]

(Sinorhizobium
meliloti) 		PF00180
(Iso_dh) 		5 LEU A 377
GLY A 284
SER A 285
LEU A 288
LEU A 120
 None
 1.11A 3e23A-3us8A:
undetectable		 3e23A-3us8A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve2 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 GLY A  39
GLY A 317
SER A 316
LEU A 327
PHE A 320
 None
 1.11A 3e23A-3ve2A:
undetectable		 3e23A-3ve2A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 139
GLY A 135
SER A 136
LEU A 131
HIS A 227
 None
 1.11A 3e23A-3zhyA:
4.5		 3e23A-3zhyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 139
GLY A 319
GLY A 135
SER A 136
LEU A 131
 None
 1.05A 3e23A-3zhyA:
4.5		 3e23A-3zhyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 139
GLY A 320
GLY A 135
LEU A 131
HIS A 227
 None
 1.05A 3e23A-3zhyA:
4.5		 3e23A-3zhyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		5 LEU A 403
GLY A 325
GLY A 331
SER A 356
LEU A 334
 None
 1.05A 3e23A-4aoaA:
undetectable		 3e23A-4aoaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6b CITRATE SYNTHASE

(Escherichia
coli) 		PF00285
(Citrate_synt) 		5 LEU A 215
GLY A 366
LEU A 369
LEU A 329
CYH A 322
 None
 0.90A 3e23A-4g6bA:
undetectable		 3e23A-4g6bA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A  28
GLY A 282
GLY A  23
LEU A  97
CYH A 100
 None
FED  A 801 (-3.5A)
FED  A 801 ( 4.7A)
None
FED  A 801 (-3.2A)
 1.11A 3e23A-4h7uA:
undetectable		 3e23A-4h7uA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A  28
GLY A 283
GLY A  23
LEU A  97
CYH A 100
 None
FED  A 801 (-3.5A)
FED  A 801 ( 4.7A)
None
FED  A 801 (-3.2A)
 0.99A 3e23A-4h7uA:
undetectable		 3e23A-4h7uA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		5 TYR A 187
GLY A 234
SER A 256
CYH A 300
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.4A)
SAH  A 501 (-4.0A)
 0.83A 3e23A-4ineA:
19.1		 3e23A-4ineA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 TYR A 183
GLY A 230
SER A 252
CYH A 296
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.4A)
SAH  A 701 (-4.2A)
 0.77A 3e23A-4kriA:
19.7		 3e23A-4kriA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		5 LEU A 945
GLY A 944
SER A 946
LEU A 447
PHE A 451
 None
 1.11A 3e23A-4mt1A:
undetectable		 3e23A-4mt1A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opm LIPASE

(Acinetobacter
baumannii) 		PF12697
(Abhydrolase_6) 		5 GLY A  76
GLY A 147
SER A 148
LEU A 145
LEU A 166
 15P  A 401 ( 4.9A)
None
15P  A 401 ( 4.0A)
15P  A 401 ( 4.9A)
None
 1.15A 3e23A-4opmA:
2.7		 3e23A-4opmA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		5 LEU A 135
GLY A 162
SER A 136
LEU A 159
LEU A  40
 None
 1.11A 3e23A-4qkfA:
undetectable		 3e23A-4qkfA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		5 LEU A 626
TYR A 629
GLY A 924
GLY A 631
SER A 630
 None
 1.03A 3e23A-4ra7A:
undetectable		 3e23A-4ra7A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rus FISH-EGG LECTIN

(Cyprinus carpio) 		PF06462
(Hyd_WA) 		5 PHE A  30
GLY A  70
GLY A  42
SER A  41
PHE A  47
 None
 1.10A 3e23A-4rusA:
undetectable		 3e23A-4rusA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS

(Mycoplasma
pneumoniae) 		PF02917
(Pertussis_S1) 		5 LEU A  38
GLY A  94
GLY A 119
LEU A 123
LEU A 257
 None
 1.15A 3e23A-4tlvA:
undetectable		 3e23A-4tlvA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS

(Mycoplasma
pneumoniae) 		PF02917
(Pertussis_S1) 		5 LEU A  38
PRO A 194
GLY A  94
GLY A 119
LEU A 123
 None
 0.92A 3e23A-4tlvA:
undetectable		 3e23A-4tlvA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wct FRUCTOSYL
AMINE:OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		5 PHE A 419
PRO A 329
GLY A 105
SER A 104
LEU A 110
 None
 1.20A 3e23A-4wctA:
2.5		 3e23A-4wctA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y67 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE,
APICOPLAST

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 TYR A 132
GLY A 164
LEU A 159
PHE A  83
CYH A 169
 None
 1.08A 3e23A-4y67A:
4.6		 3e23A-4y67A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A  18
PRO A 506
GLY A 276
GLY A  13
LEU A  86
 None
None
FAD  A 601 (-3.5A)
FAD  A 601 ( 4.6A)
None
 0.96A 3e23A-4ynuA:
undetectable		 3e23A-4ynuA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU) 		5 PHE A 461
LEU A 422
TYR A 380
LEU A 273
LEU A 450
 PHE  A 461 ( 1.3A)
LEU  A 422 ( 0.6A)
TYR  A 380 ( 1.3A)
LEU  A 273 ( 0.6A)
LEU  A 450 ( 0.6A)
 1.15A 3e23A-4zkeA:
undetectable		 3e23A-4zkeA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpi PUTATIVE
OXIDASE/HYDROXYLASE

(Streptomyces
hygroscopicus) 		PF05721
(PhyH) 		5 TYR A 155
GLY A  16
GLY A 158
SER A 159
LEU A 204
 None
 0.92A 3e23A-4zpiA:
undetectable		 3e23A-4zpiA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afd N-ACETYLNEURAMINATE
LYASE

(Aliivibrio
salmonicida) 		PF00701
(DHDPS) 		5 GLY A 164
SER A 163
LEU A 152
PHE A 151
CYH A 122
 None
 1.09A 3e23A-5afdA:
undetectable		 3e23A-5afdA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boe ENOLASE

(Staphylococcus
aureus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 305
GLY A 317
GLY A 293
LEU A 320
LEU A 278
 None
 1.20A 3e23A-5boeA:
undetectable		 3e23A-5boeA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 GLY A 433
GLY A 429
SER A 430
LEU A 431
HIS A 366
 None
 0.95A 3e23A-5cykA:
undetectable		 3e23A-5cykA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
gordonii) 		PF00534
(Glycos_transf_1) 		5 TYR A 391
GLY A 415
SER A 416
LEU A 418
LEU A 308
 None
 1.20A 3e23A-5e9uA:
undetectable		 3e23A-5e9uA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
ANTIBODY FRAGMENT
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 LEU H  70
PRO L 162
GLY H  49
LEU H  60
PHE H  64
 None
 1.12A 3e23A-5fhxH:
undetectable		 3e23A-5fhxH:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j04 ENOLASE

(Synechococcus
elongatus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 301
GLY A 313
GLY A 289
LEU A 316
LEU A 274
 None
 1.12A 3e23A-5j04A:
undetectable		 3e23A-5j04A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8r PROTOCADHERIN
GAMMA-B3

(Homo sapiens) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 LEU A  36
GLY A  18
GLY A  52
LEU A  54
LEU A  31
 None
 1.13A 3e23A-5k8rA:
undetectable		 3e23A-5k8rA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m85 SENSORY TRANSDUCTION
HISTIDINE KINASE

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU A 552
GLY A 583
GLY A 554
LEU A 555
HIS A 512
 None
 1.20A 3e23A-5m85A:
undetectable		 3e23A-5m85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN
2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens;
Pseudomonas
protegens) 		no annotation
no annotation 		5 PHE B  42
PRO C 263
GLY C 267
GLY C 249
HIS C 253
 None
 1.14A 3e23A-5mg5B:
undetectable		 3e23A-5mg5B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 PHE B 359
PRO B  48
SER B 218
CYH B 212
HIS B 358
 None
 1.18A 3e23A-5my0B:
undetectable		 3e23A-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nux CHROMATE REDUCTASE

(Thermus
scotoductus) 		no annotation 5 PHE A   5
LEU A  19
GLY A 292
LEU A 316
LEU A   4
 None
 1.13A 3e23A-5nuxA:
undetectable		 3e23A-5nuxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or7 CAPSID PROTEIN

(Norwalk virus) 		no annotation 5 LEU A 491
TYR A 492
GLY A 421
GLY A 495
LEU A 453
 None
 1.18A 3e23A-5or7A:
undetectable		 3e23A-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukn DH522UCA FAB
FRAGMENT LIGHT CHAIN

(Macaca mulatta) 		no annotation 5 PHE L  62
TYR L  49
GLY L  32
SER L  34
LEU L  73
 None
 1.20A 3e23A-5uknL:
undetectable		 3e23A-5uknL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi6 HISTONE DEACETYLASE
8

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 LEU A 327
GLY A 285
GLY A 320
LEU A  50
CYH A 314
 None
 1.08A 3e23A-5vi6A:
undetectable		 3e23A-5vi6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 LEU A 313
PRO A 157
SER A 310
LEU A 148
LEU A 373
 None
 1.16A 3e23A-5vocA:
undetectable		 3e23A-5vocA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN I
TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		no annotation
no annotation 		5 LEU X  99
TYR X  50
GLY V 123
GLY X  53
LEU X  57
 None
 1.16A 3e23A-5vtmX:
undetectable		 3e23A-5vtmX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus) 		no annotation 5 PHE B 268
LEU B 271
PRO B 147
GLY B 137
LEU B 267
 None
 1.07A 3e23A-5x1yB:
2.6		 3e23A-5x1yB:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		5 LEU A 113
GLY A  94
GLY A  37
LEU A  35
LEU A  39
 None
 1.09A 3e23A-5x2qA:
undetectable		 3e23A-5x2qA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xge UNCHARACTERIZED
PROTEIN PA0861

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 313
PRO A 742
GLY A 320
GLY A 341
LEU A 355
 None
 1.12A 3e23A-5xgeA:
undetectable		 3e23A-5xgeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5

(Aquareovirus C) 		no annotation 5 PHE B 111
LEU B 108
GLY B  77
SER B  83
LEU B 145
 None
 1.16A 3e23A-5zvtB:
undetectable		 3e23A-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1

(Danio rerio) 		no annotation 5 LEU A  44
PRO A 110
SER A  78
LEU A  69
PHE A  66
 None
 1.18A 3e23A-6b82A:
undetectable		 3e23A-6b82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cj7 SERPIN-12

(Manduca sexta) 		no annotation 5 LEU A  89
PRO A  58
GLY A  41
GLY A 294
LEU A 290
 None
 1.04A 3e23A-6cj7A:
undetectable		 3e23A-6cj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA

(Norwalk virus) 		no annotation 5 LEU B 491
TYR B 492
GLY B 421
GLY B 495
LEU B 453
 None
 1.19A 3e23A-6crjB:
undetectable		 3e23A-6crjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE

(Homo sapiens) 		no annotation 5 GLY A 438
GLY A 444
SER A 443
LEU A 392
HIS A 428
 None
 1.13A 3e23A-6dd3A:
undetectable		 3e23A-6dd3A:
undetectable