SIMILAR PATTERNS OF AMINO ACIDS FOR 3E23_A_SAMA221

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef1 MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 LEU A 225
GLY A 202
GLY A 219
LEU A 218
PHE A 206
 None
 1.19A 3e23A-1ef1A:
undetectable		 3e23A-1ef1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0u PROTEASOME COMPONENT
PUP2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 LEU D 148
TYR D 160
GLY D  39
LEU D  48
HIS D 150
 None
 1.07A 3e23A-1g0uD:
undetectable		 3e23A-1g0uD:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 PHE A 407
GLY A 117
GLY A 203
SER A 205
LEU A 224
 None
SAF  A1998 (-3.1A)
None
None
None
 1.06A 3e23A-1gqrA:
undetectable		 3e23A-1gqrA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4r MERLIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 LEU A 241
GLY A 218
GLY A 235
LEU A 234
PHE A 222
 None
 1.20A 3e23A-1h4rA:
undetectable		 3e23A-1h4rA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 PRO A  57
GLY A 164
SER A 163
CYH A 103
HIS A 101
 None
 1.20A 3e23A-1jxkA:
undetectable		 3e23A-1jxkA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A  85
GLY A 224
SER A 223
LEU A 112
LEU A 258
 None
 1.03A 3e23A-1l8kA:
undetectable		 3e23A-1l8kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV

(Griffonia
simplicifolia) 		PF00139
(Lectin_legB) 		5 PHE A  78
LEU A  80
GLY A 222
GLY A  90
LEU A  91
 None
None
GAL  A 253 (-3.5A)
None
None
 1.09A 3e23A-1ledA:
undetectable		 3e23A-1ledA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oht CG14704 PROTEIN

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		5 TYR A  78
GLY A  81
GLY A  91
SER A  79
HIS A  67
 None
 1.10A 3e23A-1ohtA:
undetectable		 3e23A-1ohtA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		5 LEU A 391
PRO A 145
GLY A 482
GLY A 484
LEU A 335
 None
None
None
PO4  A3000 ( 3.8A)
None
 1.19A 3e23A-1qhbA:
undetectable		 3e23A-1qhbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2j PROTEIN FKBI

(Streptomyces
hygroscopicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 217
GLY A  89
GLY A 209
SER A 210
LEU A 207
 None
 1.10A 3e23A-1r2jA:
undetectable		 3e23A-1r2jA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 LEU A  71
GLY A 179
LEU A 182
LEU A 141
HIS A  75
 None
 1.19A 3e23A-1rtrA:
undetectable		 3e23A-1rtrA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slm STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 LEU A 245
GLY A  88
GLY A 208
LEU A 209
PHE A 210
 None
 0.92A 3e23A-1slmA:
undetectable		 3e23A-1slmA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vq0 33 KDA CHAPERONIN

(Thermotoga
maritima) 		PF01430
(HSP33) 		5 LEU A  62
GLY A  41
GLY A  46
LEU A  44
LEU A 140
 None
 1.06A 3e23A-1vq0A:
undetectable		 3e23A-1vq0A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yis ADENYLOSUCCINATE
LYASE

(Caenorhabditis
elegans) 		PF00206
(Lyase_1) 		5 LEU A 207
GLY A 196
GLY A 105
SER A 203
LEU A 104
 None
SO4  A1001 (-2.8A)
None
None
None
 1.17A 3e23A-1yisA:
undetectable		 3e23A-1yisA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 TYR A 111
GLY A 113
GLY A 105
SER A 106
LEU A 165
 None
 1.17A 3e23A-1yrwA:
3.9		 3e23A-1yrwA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz1 TRANSLATIONALLY
CONTROLLED TUMOR
PROTEIN

(Homo sapiens) 		PF00838
(TCTP) 		5 TYR A  18
GLY A  33
LEU A  29
PHE A 162
HIS A  76
 None
 1.10A 3e23A-1yz1A:
undetectable		 3e23A-1yz1A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 LEU A 181
TYR A 180
GLY A 139
GLY A 126
LEU A 150
 None
FAD  A 301 ( 4.7A)
None
None
None
 1.19A 3e23A-2culA:
3.5		 3e23A-2culA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		5 PHE A  62
GLY A 215
GLY A 360
LEU A 412
PHE A 411
 None
 1.16A 3e23A-2cy8A:
2.5		 3e23A-2cy8A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy3 ALANINE RACEMASE

(Corynebacterium
glutamicum) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 PRO A 224
GLY A 216
GLY A  58
LEU A  78
HIS A 158
 None
PLP  A 401 (-3.5A)
None
None
PLP  A 401 (-4.0A)
 1.18A 3e23A-2dy3A:
undetectable		 3e23A-2dy3A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgn PHOSPHOLIPASE C

(Bacillus cereus) 		PF00882
(Zn_dep_PLPC) 		5 LEU A 117
GLY A 114
SER A 116
LEU A  47
HIS A  14
 None
None
None
None
ZN  A 248 (-3.3A)
 1.19A 3e23A-2fgnA:
undetectable		 3e23A-2fgnA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 PRO A 315
GLY A 400
GLY A 403
LEU A 254
HIS A 584
 None
 1.11A 3e23A-2fjaA:
2.2		 3e23A-2fjaA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE

(Homo sapiens) 		PF00171
(Aldedh) 		5 PRO A 575
GLY A 498
SER A 497
LEU A 757
LEU A 377
 None
 1.12A 3e23A-2h5gA:
undetectable		 3e23A-2h5gA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
pneumoniae) 		PF01408
(GFO_IDH_MocA) 		5 LEU A 183
TYR A 184
GLY A 179
LEU A 175
HIS A 307
 None
 1.12A 3e23A-2ho5A:
4.2		 3e23A-2ho5A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kwo ZINC FINGER PROTEIN
DPF3

(Homo sapiens) 		PF00628
(PHD) 		5 GLY A 268
GLY A 291
SER A 290
LEU A 296
CYH A 265
 None
SAC  B   1 ( 4.9A)
None
SAC  B   1 ( 3.4A)
ZN  A 501 (-2.3A)
 1.09A 3e23A-2kwoA:
undetectable		 3e23A-2kwoA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		5 LEU A 255
PRO A 137
GLY A 129
GLY A 101
LEU A  95
 None
 1.04A 3e23A-2o1bA:
3.9		 3e23A-2o1bA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2g DIENELACTONE
HYDROLASE

(Trichormus
variabilis) 		PF01738
(DLH) 		5 PHE A 217
LEU A  64
GLY A  32
GLY A  35
LEU A 221
 None
 1.15A 3e23A-2o2gA:
3.1		 3e23A-2o2gA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqh PUTATIVE ISOMERASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TYR A 221
PRO A 129
GLY A 293
LEU A 292
HIS A 268
 None
 1.18A 3e23A-2oqhA:
undetectable		 3e23A-2oqhA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxx DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE

(Mycobacterium
tuberculosis) 		PF00692
(dUTPase) 		5 LEU A  36
GLY A 176
GLY A  82
LEU A  39
LEU A 130
 None
 1.15A 3e23A-2qxxA:
undetectable		 3e23A-2qxxA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN

(Homo sapiens) 		PF00782
(DSPc) 		5 LEU A 110
GLY A  56
GLY A  35
LEU A  36
HIS A  59
 None
 1.17A 3e23A-2r0bA:
undetectable		 3e23A-2r0bA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		5 LEU A 118
TYR A 115
GLY A 113
SER A 114
LEU A  88
 None
 1.19A 3e23A-2vlcA:
undetectable		 3e23A-2vlcA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vou 2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE

(Paenarthrobacter
nicotinovorans) 		PF00070
(Pyr_redox) 		5 LEU A  41
PRO A 164
GLY A 150
GLY A  13
SER A  14
 FAD  A1395 (-4.5A)
None
FAD  A1395 (-3.3A)
FAD  A1395 ( 4.7A)
FAD  A1395 (-2.8A)
 1.11A 3e23A-2vouA:
3.1		 3e23A-2vouA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 LEU A 478
GLY A 357
LEU A 353
LEU A 361
HIS A 587
 None
 1.13A 3e23A-2wpgA:
undetectable		 3e23A-2wpgA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Thermotoga
maritima) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 106
PRO A 347
GLY A 123
LEU A  99
LEU A 138
 None
 1.17A 3e23A-3a14A:
3.7		 3e23A-3a14A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A  83
GLY A 223
SER A 222
LEU A 110
LEU A 260
 None
 1.03A 3e23A-3a5kA:
undetectable		 3e23A-3a5kA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 TYR A 132
GLY A 164
LEU A 159
PHE A  83
CYH A 169
 None
 1.11A 3e23A-3au9A:
2.7		 3e23A-3au9A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 5 LEU A 626
GLY A 635
LEU A 636
LEU A 644
CYH A 578
 None
 1.13A 3e23A-3c2gA:
undetectable		 3e23A-3c2gA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c87 ENTEROCHELIN
ESTERASE

(Shigella
flexneri) 		PF00756
(Esterase)
PF11806
(DUF3327) 		5 LEU A 378
PRO A 346
GLY A  55
GLY A  89
SER A  90
 None
 1.12A 3e23A-3c87A:
undetectable		 3e23A-3c87A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE

(Methanosarcina
mazei) 		PF01933
(UPF0052) 		5 LEU A  13
PRO A  45
GLY A   6
GLY A 190
LEU A 188
 None
 1.19A 3e23A-3cgwA:
undetectable		 3e23A-3cgwA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE

(Methanosarcina
mazei) 		PF01933
(UPF0052) 		5 LEU A  13
PRO A  45
GLY A   7
GLY A 190
LEU A 188
 None
 1.19A 3e23A-3cgwA:
undetectable		 3e23A-3cgwA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctk RRNA N-GLYCOSIDASE

(Bougainvillea
spectabilis) 		PF00161
(RIP) 		5 LEU A 117
TYR A 114
GLY A 112
SER A 113
LEU A  87
 None
 1.14A 3e23A-3ctkA:
undetectable		 3e23A-3ctkA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		5 LEU A 477
GLY A 356
LEU A 352
LEU A 360
HIS A 586
 None
 1.05A 3e23A-3czeA:
undetectable		 3e23A-3czeA:
17.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris) 		PF08241
(Methyltransf_11) 		12 PHE A   9
LEU A  14
TYR A  17
PRO A  29
GLY A  53
GLY A  73
SER A  74
LEU A  77
LEU A  93
PHE A  94
CYH A 111
HIS A 114
 None
SAM  A 221 (-4.4A)
SAM  A 221 (-3.8A)
SAM  A 221 (-4.1A)
SAM  A 221 (-3.2A)
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
SAM  A 221 (-4.3A)
SAM  A 221 (-4.0A)
SAM  A 221 (-3.3A)
SAM  A 221 (-4.8A)
SAM  A 221 (-4.3A)
 0.02A 3e23A-3e23A:
41.5		 3e23A-3e23A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 LEU A 145
PRO A 871
GLY A 806
GLY A  97
CYH A 139
 None
None
None
None
FES  A 908 ( 2.4A)
 1.01A 3e23A-3fahA:
undetectable		 3e23A-3fahA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hug RNA POLYMERASE SIGMA
FACTOR
PROBABLE CONSERVED
MEMBRANE PROTEIN

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF04545
(Sigma70_r4)
PF13490
(zf-HC2) 		5 TYR A 135
GLY B  37
GLY A 138
SER A 134
LEU B  36
 None
 1.19A 3e23A-3hugA:
undetectable		 3e23A-3hugA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1

(Pseudomonas
aeruginosa) 		PF05567
(Neisseria_PilC) 		5 LEU A 690
GLY A 758
GLY A 750
LEU A 752
LEU A 748
 None
 1.16A 3e23A-3hx6A:
undetectable		 3e23A-3hx6A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		5 PHE A1484
GLY A  21
GLY A1157
SER A1155
LEU A  17
 None
 0.83A 3e23A-3jroA:
undetectable		 3e23A-3jroA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kda CFTR INHIBITORY
FACTOR (CIF)

(Pseudomonas
aeruginosa) 		no annotation 5 PRO D 157
GLY D  64
LEU D 200
PHE D 203
HIS D 297
 None
 0.99A 3e23A-3kdaD:
2.2		 3e23A-3kdaD:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm6 STAGE V SPORULATION
PROTEIN AD

(Bacillus
subtilis) 		PF07451
(SpoVAD) 		5 LEU A 263
GLY A 202
GLY A 237
SER A 236
HIS A 258
 None
 1.15A 3e23A-3lm6A:
undetectable		 3e23A-3lm6A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqe CAPSID PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		5 LEU A 491
TYR A 492
GLY A 421
GLY A 495
LEU A 453
 None
 1.17A 3e23A-3lqeA:
undetectable		 3e23A-3lqeA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 LEU A 272
TYR A 275
GLY A 302
LEU A 306
HIS A 249
 None
LWY  A 427 ( 4.7A)
None
None
ZN  A 426 ( 3.8A)
 1.04A 3e23A-3n2cA:
undetectable		 3e23A-3n2cA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus) 		PF13649
(Methyltransf_25) 		5 LEU A  12
TYR A  15
GLY A  56
GLY A  76
SER A  77
 SAM  A 300 ( 3.9A)
SAM  A 300 ( 3.5A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-4.5A)
 0.77A 3e23A-3ou6A:
19.0		 3e23A-3ou6A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PRO A 195
GLY A 296
LEU A 297
LEU A 333
PHE A 267
 None
 1.18A 3e23A-3ppsA:
undetectable		 3e23A-3ppsA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE (INO1)

(Archaeoglobus
fulgidus) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 GLY A  32
SER A  35
LEU A  33
LEU A 384
PHE A 364
 None
 1.09A 3e23A-3qw2A:
2.3		 3e23A-3qw2A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us8 ISOCITRATE
DEHYDROGENASE [NADP]

(Sinorhizobium
meliloti) 		PF00180
(Iso_dh) 		5 LEU A 377
GLY A 284
SER A 285
LEU A 288
LEU A 120
 None
 1.11A 3e23A-3us8A:
undetectable		 3e23A-3us8A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve2 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 GLY A  39
GLY A 317
SER A 316
LEU A 327
PHE A 320
 None
 1.11A 3e23A-3ve2A:
undetectable		 3e23A-3ve2A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 139
GLY A 135
SER A 136
LEU A 131
HIS A 227
 None
 1.11A 3e23A-3zhyA:
4.5		 3e23A-3zhyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 139
GLY A 319
GLY A 135
SER A 136
LEU A 131
 None
 1.05A 3e23A-3zhyA:
4.5		 3e23A-3zhyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 139
GLY A 320
GLY A 135
LEU A 131
HIS A 227
 None
 1.05A 3e23A-3zhyA:
4.5		 3e23A-3zhyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		5 LEU A 403
GLY A 325
GLY A 331
SER A 356
LEU A 334
 None
 1.05A 3e23A-4aoaA:
undetectable		 3e23A-4aoaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6b CITRATE SYNTHASE

(Escherichia
coli) 		PF00285
(Citrate_synt) 		5 LEU A 215
GLY A 366
LEU A 369
LEU A 329
CYH A 322
 None
 0.90A 3e23A-4g6bA:
undetectable		 3e23A-4g6bA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A  28
GLY A 282
GLY A  23
LEU A  97
CYH A 100
 None
FED  A 801 (-3.5A)
FED  A 801 ( 4.7A)
None
FED  A 801 (-3.2A)
 1.11A 3e23A-4h7uA:
undetectable		 3e23A-4h7uA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A  28
GLY A 283
GLY A  23
LEU A  97
CYH A 100
 None
FED  A 801 (-3.5A)
FED  A 801 ( 4.7A)
None
FED  A 801 (-3.2A)
 0.99A 3e23A-4h7uA:
undetectable		 3e23A-4h7uA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		5 TYR A 187
GLY A 234
SER A 256
CYH A 300
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.4A)
SAH  A 501 (-4.0A)
 0.83A 3e23A-4ineA:
19.1		 3e23A-4ineA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 TYR A 183
GLY A 230
SER A 252
CYH A 296
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.4A)
SAH  A 701 (-4.2A)
 0.77A 3e23A-4kriA:
19.7		 3e23A-4kriA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		5 LEU A 945
GLY A 944
SER A 946
LEU A 447
PHE A 451
 None
 1.11A 3e23A-4mt1A:
undetectable		 3e23A-4mt1A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opm LIPASE

(Acinetobacter
baumannii) 		PF12697
(Abhydrolase_6) 		5 GLY A  76
GLY A 147
SER A 148
LEU A 145
LEU A 166
 15P  A 401 ( 4.9A)
None
15P  A 401 ( 4.0A)
15P  A 401 ( 4.9A)
None
 1.15A 3e23A-4opmA:
2.7		 3e23A-4opmA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		5 LEU A 135
GLY A 162
SER A 136
LEU A 159
LEU A  40
 None
 1.11A 3e23A-4qkfA:
undetectable		 3e23A-4qkfA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		5 LEU A 626
TYR A 629
GLY A 924
GLY A 631
SER A 630
 None
 1.03A 3e23A-4ra7A:
undetectable		 3e23A-4ra7A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rus FISH-EGG LECTIN

(Cyprinus carpio) 		PF06462
(Hyd_WA) 		5 PHE A  30
GLY A  70
GLY A  42
SER A  41
PHE A  47
 None
 1.10A 3e23A-4rusA:
undetectable		 3e23A-4rusA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS

(Mycoplasma
pneumoniae) 		PF02917
(Pertussis_S1) 		5 LEU A  38
GLY A  94
GLY A 119
LEU A 123
LEU A 257
 None
 1.15A 3e23A-4tlvA:
undetectable		 3e23A-4tlvA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS

(Mycoplasma
pneumoniae) 		PF02917
(Pertussis_S1) 		5 LEU A  38
PRO A 194
GLY A  94
GLY A 119
LEU A 123
 None
 0.92A 3e23A-4tlvA:
undetectable		 3e23A-4tlvA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wct FRUCTOSYL
AMINE:OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		5 PHE A 419
PRO A 329
GLY A 105
SER A 104
LEU A 110
 None
 1.20A 3e23A-4wctA:
2.5		 3e23A-4wctA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y67 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE,
APICOPLAST

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 TYR A 132
GLY A 164
LEU A 159
PHE A  83
CYH A 169
 None
 1.08A 3e23A-4y67A:
4.6		 3e23A-4y67A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A  18
PRO A 506
GLY A 276
GLY A  13
LEU A  86
 None
None
FAD  A 601 (-3.5A)
FAD  A 601 ( 4.6A)
None
 0.96A 3e23A-4ynuA:
undetectable		 3e23A-4ynuA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU) 		5 PHE A 461
LEU A 422
TYR A 380
LEU A 273
LEU A 450
 PHE  A 461 ( 1.3A)
LEU  A 422 ( 0.6A)
TYR  A 380 ( 1.3A)
LEU  A 273 ( 0.6A)
LEU  A 450 ( 0.6A)
 1.15A 3e23A-4zkeA:
undetectable		 3e23A-4zkeA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpi PUTATIVE
OXIDASE/HYDROXYLASE

(Streptomyces
hygroscopicus) 		PF05721
(PhyH) 		5 TYR A 155
GLY A  16
GLY A 158
SER A 159
LEU A 204
 None
 0.92A 3e23A-4zpiA:
undetectable		 3e23A-4zpiA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afd N-ACETYLNEURAMINATE
LYASE

(Aliivibrio
salmonicida) 		PF00701
(DHDPS) 		5 GLY A 164
SER A 163
LEU A 152
PHE A 151
CYH A 122
 None
 1.09A 3e23A-5afdA:
undetectable		 3e23A-5afdA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boe ENOLASE

(Staphylococcus
aureus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 305
GLY A 317
GLY A 293
LEU A 320
LEU A 278
 None
 1.20A 3e23A-5boeA:
undetectable		 3e23A-5boeA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 GLY A 433
GLY A 429
SER A 430
LEU A 431
HIS A 366
 None
 0.95A 3e23A-5cykA:
undetectable		 3e23A-5cykA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
gordonii) 		PF00534
(Glycos_transf_1) 		5 TYR A 391
GLY A 415
SER A 416
LEU A 418
LEU A 308
 None
 1.20A 3e23A-5e9uA:
undetectable		 3e23A-5e9uA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
ANTIBODY FRAGMENT
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 LEU H  70
PRO L 162
GLY H  49
LEU H  60
PHE H  64
 None
 1.12A 3e23A-5fhxH:
undetectable		 3e23A-5fhxH:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j04 ENOLASE

(Synechococcus
elongatus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 301
GLY A 313
GLY A 289
LEU A 316
LEU A 274
 None
 1.12A 3e23A-5j04A:
undetectable		 3e23A-5j04A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8r PROTOCADHERIN
GAMMA-B3

(Homo sapiens) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 LEU A  36
GLY A  18
GLY A  52
LEU A  54
LEU A  31
 None
 1.13A 3e23A-5k8rA:
undetectable		 3e23A-5k8rA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m85 SENSORY TRANSDUCTION
HISTIDINE KINASE

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU A 552
GLY A 583
GLY A 554
LEU A 555
HIS A 512
 None
 1.20A 3e23A-5m85A:
undetectable		 3e23A-5m85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN
2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens;
Pseudomonas
protegens) 		no annotation
no annotation 		5 PHE B  42
PRO C 263
GLY C 267
GLY C 249
HIS C 253
 None
 1.14A 3e23A-5mg5B:
undetectable		 3e23A-5mg5B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 PHE B 359
PRO B  48
SER B 218
CYH B 212
HIS B 358
 None
 1.18A 3e23A-5my0B:
undetectable		 3e23A-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nux CHROMATE REDUCTASE

(Thermus
scotoductus) 		no annotation 5 PHE A   5
LEU A  19
GLY A 292
LEU A 316
LEU A   4
 None
 1.13A 3e23A-5nuxA:
undetectable		 3e23A-5nuxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or7 CAPSID PROTEIN

(Norwalk virus) 		no annotation 5 LEU A 491
TYR A 492
GLY A 421
GLY A 495
LEU A 453
 None
 1.18A 3e23A-5or7A:
undetectable		 3e23A-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukn DH522UCA FAB
FRAGMENT LIGHT CHAIN

(Macaca mulatta) 		no annotation 5 PHE L  62
TYR L  49
GLY L  32
SER L  34
LEU L  73
 None
 1.20A 3e23A-5uknL:
undetectable		 3e23A-5uknL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi6 HISTONE DEACETYLASE
8

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 LEU A 327
GLY A 285
GLY A 320
LEU A  50
CYH A 314
 None
 1.08A 3e23A-5vi6A:
undetectable		 3e23A-5vi6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 LEU A 313
PRO A 157
SER A 310
LEU A 148
LEU A 373
 None
 1.16A 3e23A-5vocA:
undetectable		 3e23A-5vocA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN I
TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		no annotation
no annotation 		5 LEU X  99
TYR X  50
GLY V 123
GLY X  53
LEU X  57
 None
 1.16A 3e23A-5vtmX:
undetectable		 3e23A-5vtmX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus) 		no annotation 5 PHE B 268
LEU B 271
PRO B 147
GLY B 137
LEU B 267
 None
 1.07A 3e23A-5x1yB:
2.6		 3e23A-5x1yB:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		5 LEU A 113
GLY A  94
GLY A  37
LEU A  35
LEU A  39
 None
 1.09A 3e23A-5x2qA:
undetectable		 3e23A-5x2qA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xge UNCHARACTERIZED
PROTEIN PA0861

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 313
PRO A 742
GLY A 320
GLY A 341
LEU A 355
 None
 1.12A 3e23A-5xgeA:
undetectable		 3e23A-5xgeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5

(Aquareovirus C) 		no annotation 5 PHE B 111
LEU B 108
GLY B  77
SER B  83
LEU B 145
 None
 1.16A 3e23A-5zvtB:
undetectable		 3e23A-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1

(Danio rerio) 		no annotation 5 LEU A  44
PRO A 110
SER A  78
LEU A  69
PHE A  66
 None
 1.18A 3e23A-6b82A:
undetectable		 3e23A-6b82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cj7 SERPIN-12

(Manduca sexta) 		no annotation 5 LEU A  89
PRO A  58
GLY A  41
GLY A 294
LEU A 290
 None
 1.04A 3e23A-6cj7A:
undetectable		 3e23A-6cj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA

(Norwalk virus) 		no annotation 5 LEU B 491
TYR B 492
GLY B 421
GLY B 495
LEU B 453
 None
 1.19A 3e23A-6crjB:
undetectable		 3e23A-6crjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE

(Homo sapiens) 		no annotation 5 GLY A 438
GLY A 444
SER A 443
LEU A 392
HIS A 428
 None
 1.13A 3e23A-6dd3A:
undetectable		 3e23A-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
12as ASPARAGINE
SYNTHETASE

(Escherichia
coli) 		PF03590
(AsnA) 		3 TYR A 218
ASP A 118
HIS A  71
 ASN  A 331 (-4.3A)
ASN  A 331 (-3.3A)
None
 0.73A 3e23A-12asA:
undetectable		 3e23A-12asA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE

(Arthrobacter
sp. 1C) 		PF02317
(Octopine_DH)
PF02558
(ApbA) 		3 TYR A 259
ASP A 238
HIS A 202
 None
 0.79A 3e23A-1bg6A:
4.5		 3e23A-1bg6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		3 TYR A 130
ASP A 175
HIS A  55
 None
None
FAD  A 801 ( 4.9A)
 0.88A 3e23A-1e1kA:
undetectable		 3e23A-1e1kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 TYR A 204
ASP A  35
HIS A  40
 None
 0.78A 3e23A-1eu1A:
undetectable		 3e23A-1eu1A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 TYR A 253
ASP A 210
HIS A 226
 None
PLP  A1201 (-2.7A)
None
 0.88A 3e23A-1fc4A:
undetectable		 3e23A-1fc4A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)

(Allochromatium
vinosum;
Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind)
no annotation 		3 TYR A 306
ASP A 398
HIS C  15
 None
None
HEM  C 901 (-3.3A)
 0.90A 3e23A-1fcdA:
undetectable		 3e23A-1fcdA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 TYR A 152
ASP A 178
HIS A 242
 None
PQQ  A 701 (-3.5A)
None
 0.95A 3e23A-1flgA:
undetectable		 3e23A-1flgA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 TYR A 797
ASP A 441
HIS A 195
 MGD  A5001 (-3.8A)
None
MGD  A5001 (-4.5A)
 0.91A 3e23A-1g8kA:
undetectable		 3e23A-1g8kA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 TYR A 977
ASP A 998
HIS A 950
 None
 0.95A 3e23A-1hwwA:
undetectable		 3e23A-1hwwA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		3 TYR A 132
ASP A 177
HIS A  57
 None
None
ACT  A1869 (-3.7A)
 0.91A 3e23A-1lqtA:
undetectable		 3e23A-1lqtA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		3 TYR A 326
ASP A 351
HIS A 397
 AMP  A 706 (-4.1A)
MG  A 604 (-2.7A)
None
 0.78A 3e23A-1mb9A:
2.8		 3e23A-1mb9A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnh ASPARAGINYL-TRNA
SYNTHETASE-RELATED
PEPTIDE

(Pyrococcus
furiosus) 		PF00152
(tRNA-synt_2) 		3 TYR A 194
ASP A 118
HIS A  74
 None
 0.92A 3e23A-1nnhA:
undetectable		 3e23A-1nnhA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt4 GLUCOSE-1-PHOSPHATAS
E

(Escherichia
coli) 		PF00328
(His_Phos_2) 		3 TYR A 268
ASP A 124
HIS A 115
 None
 0.68A 3e23A-1nt4A:
undetectable		 3e23A-1nt4A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
SMALL SUBUNIT

(Rhodococcus
jostii) 		PF00866
(Ring_hydroxyl_B) 		3 TYR B  55
ASP B 153
HIS B 111
 None
 0.71A 3e23A-1uliB:
undetectable		 3e23A-1uliB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		3 TYR A 550
ASP A 515
HIS A 539
 None
None
LBT  A1648 (-3.9A)
 0.87A 3e23A-1w8oA:
undetectable		 3e23A-1w8oA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas
fluorescens) 		PF00866
(Ring_hydroxyl_B) 		3 TYR B  54
ASP B 152
HIS B 110
 None
 0.72A 3e23A-1wqlB:
undetectable		 3e23A-1wqlB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		3 TYR A  64
ASP A   5
HIS A  19
 None
MG  A3001 (-3.2A)
None
 0.61A 3e23A-1x9sA:
undetectable		 3e23A-1x9sA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpn HYPOTHETICAL PROTEIN
PA1324

(Pseudomonas
aeruginosa) 		no annotation 3 TYR A 107
ASP A 101
HIS A  33
 None
 0.86A 3e23A-1xpnA:
undetectable		 3e23A-1xpnA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B

(Sulfolobus
shibatae) 		PF02518
(HATPase_c)
PF05833
(FbpA)
PF09239
(Topo-VIb_trans) 		3 TYR A 422
ASP A 386
HIS A 414
 None
 0.86A 3e23A-1z5aA:
undetectable		 3e23A-1z5aA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 TYR A 236
ASP A 190
HIS A 357
 None
 0.95A 3e23A-2akjA:
undetectable		 3e23A-2akjA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE SMALL
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00866
(Ring_hydroxyl_B) 		3 TYR B 551
ASP B 647
HIS B 604
 None
 0.75A 3e23A-2b24B:
undetectable		 3e23A-2b24B:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej5 ENOYL-COA HYDRATASE
SUBUNIT II

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		3 TYR A 147
ASP A 119
HIS A  94
 None
 0.90A 3e23A-2ej5A:
undetectable		 3e23A-2ej5A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcc ENDONUCLEASE V

(Escherichia
virus T4) 		PF03013
(Pyr_excise) 		3 TYR A 104
ASP A  62
HIS A  56
 SO4  A 501 (-4.8A)
None
None
 0.97A 3e23A-2fccA:
undetectable		 3e23A-2fccA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frv PERIPLASMIC
HYDROGENASE

(Desulfovibrio
gigas) 		no annotation 3 TYR L 268
ASP L 189
HIS L 179
 None
 0.79A 3e23A-2frvL:
undetectable		 3e23A-2frvL:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		3 TYR A 223
ASP A  59
HIS A 258
 None
None
ZN  A1000 (-3.2A)
 0.86A 3e23A-2gsnA:
undetectable		 3e23A-2gsnA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pso STAR-RELATED LIPID
TRANSFER PROTEIN 13

(Homo sapiens) 		PF01852
(START) 		3 TYR A 999
ASP A 978
HIS A1068
 None
 0.93A 3e23A-2psoA:
undetectable		 3e23A-2psoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqr PUTATIVE SULFATASE

(Rhizobium
leguminosarum) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 TYR A 290
ASP A  17
HIS A 325
 None
None
MN  A1515 ( 3.3A)
 0.95A 3e23A-2vqrA:
undetectable		 3e23A-2vqrA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 TYR A  31
ASP A  85
HIS A 141
 None
None
CL  A 401 (-4.1A)
 0.84A 3e23A-2w2jA:
undetectable		 3e23A-2w2jA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 TYR A 290
ASP A  17
HIS A 325
 None
None
ZN  A1515 ( 3.2A)
 0.92A 3e23A-2w8sA:
undetectable		 3e23A-2w8sA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 TYR A 390
ASP A 245
HIS A 233
 None
 0.90A 3e23A-2wd9A:
undetectable		 3e23A-2wd9A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		3 TYR A 383
ASP A 451
HIS A  45
 None
BR  A1482 ( 4.3A)
None
 0.97A 3e23A-2xhyA:
undetectable		 3e23A-2xhyA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		3 TYR A 109
ASP A 160
HIS A 206
 None
 0.65A 3e23A-2z7xA:
undetectable		 3e23A-2z7xA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE

(Shewanella sp.
AP1) 		PF00245
(Alk_phosphatase) 		3 TYR A  47
ASP A 366
HIS A 387
 None
 0.95A 3e23A-3a52A:
undetectable		 3e23A-3a52A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli) 		PF01343
(Peptidase_S49) 		3 TYR A 133
ASP A  69
HIS A 546
 None
 0.85A 3e23A-3bf0A:
undetectable		 3e23A-3bf0A:
16.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris) 		PF08241
(Methyltransf_11) 		3 TYR A  24
ASP A  72
HIS A 109
 SAM  A 221 (-4.7A)
SAM  A 221 (-2.8A)
SAM  A 221 ( 3.7A)
 0.00A 3e23A-3e23A:
41.5		 3e23A-3e23A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eby BETA SUBUNIT OF A
PUTATIVE
AROMATIC-RING-HYDROX
YLATING DIOXYGENASE

(Novosphingobium
aromaticivorans) 		PF00866
(Ring_hydroxyl_B) 		3 TYR A  44
ASP A 131
HIS A  89
 None
 0.88A 3e23A-3ebyA:
undetectable		 3e23A-3ebyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT BETA

(Pseudomonas
putida) 		PF00866
(Ring_hydroxyl_B) 		3 TYR B  55
ASP B 153
HIS B 111
 None
 0.74A 3e23A-3eqqB:
undetectable		 3e23A-3eqqB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE

(Xylella
fastidiosa) 		PF07221
(GlcNAc_2-epim) 		3 TYR A 342
ASP A  11
HIS A  21
 None
 0.88A 3e23A-3gt5A:
undetectable		 3e23A-3gt5A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Comamonas
testosteroni) 		PF00866
(Ring_hydroxyl_B) 		3 TYR B  54
ASP B 152
HIS B 110
 None
 0.69A 3e23A-3gzyB:
undetectable		 3e23A-3gzyB:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwc CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 2

(Burkholderia
cepacia) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		3 TYR A3036
ASP A3253
HIS A3105
 None
 0.81A 3e23A-3hwcA:
undetectable		 3e23A-3hwcA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 TYR A 177
ASP A 160
HIS A 146
 None
None
LLX  A 400 (-3.8A)
 0.85A 3e23A-3maxA:
3.4		 3e23A-3maxA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn8 LP15968P

(Drosophila
melanogaster) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 TYR A 283
ASP A 270
HIS A 217
 GEM  A 601 (-3.3A)
None
ZN  A 999 ( 3.2A)
 0.79A 3e23A-3mn8A:
undetectable		 3e23A-3mn8A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE

(Enterobacter
cloacae) 		PF00328
(His_Phos_2) 		3 TYR A 266
ASP A 122
HIS A 113
 None
 0.73A 3e23A-3ntlA:
undetectable		 3e23A-3ntlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN

(Pyrococcus
abyssi) 		PF00152
(tRNA-synt_2) 		3 TYR A 194
ASP A 118
HIS A  74
 None
 0.87A 3e23A-3p8tA:
undetectable		 3e23A-3p8tA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnd THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE

(Salmonella
enterica) 		PF02424
(ApbE) 		3 TYR A  78
ASP A 181
HIS A 270
 FAD  A 500 (-3.7A)
FAD  A 500 (-3.2A)
SO4  A 362 (-4.0A)
 0.89A 3e23A-3pndA:
undetectable		 3e23A-3pndA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk UREASE SUBUNIT BETA
2

(Helicobacter
mustelae) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 TYR C  38
ASP C  18
HIS C  33
 None
 0.96A 3e23A-3qgkC:
undetectable		 3e23A-3qgkC:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfg 3F8 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H  32
ASP H 101
HIS H  98
 None
 0.93A 3e23A-3vfgH:
undetectable		 3e23A-3vfgH:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
HEME SUBUNIT
FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum;
Thermochromatium
tepidum) 		no annotation
PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		3 TYR B 306
ASP B 398
HIS A  15
 None
None
HEC  A 201 (-3.2A)
 0.72A 3e23A-3vrdB:
1.8		 3e23A-3vrdB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		3 TYR A 211
ASP A 360
HIS A 363
 None
 0.93A 3e23A-3vtrA:
undetectable		 3e23A-3vtrA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a69 HISTONE DEACETYLASE
3,

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 TYR A 166
ASP A 149
HIS A 135
 None
None
ACT  A 501 (-3.7A)
 0.82A 3e23A-4a69A:
3.3		 3e23A-4a69A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		3 TYR A  30
ASP A 580
HIS A 587
 None
 0.88A 3e23A-4amfA:
undetectable		 3e23A-4amfA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bdu GREEN FLUORESCENT
PROTEIN, APOPTOSIS
REGULATOR BAX

(Aequorea
victoria;
Homo sapiens) 		PF00452
(Bcl-2)
PF01353
(GFP) 		3 TYR A 106
ASP A 103
HIS A 139
 None
 0.89A 3e23A-4bduA:
undetectable		 3e23A-4bduA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ber PHOSPHOCHOLINE
TRANSFERASE ANKX

(Legionella
pneumophila) 		PF02661
(Fic)
PF12796
(Ank_2) 		3 TYR A 431
ASP A 462
HIS A 176
 None
 0.81A 3e23A-4berA:
undetectable		 3e23A-4berA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx HISTONE DEACETYLASE
1

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 TYR B 172
ASP B 155
HIS B 141
 None
None
ACT  B 601 (-3.8A)
 0.81A 3e23A-4bkxB:
3.2		 3e23A-4bkxB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz7 HISTONE DEACETYLASE
8

(Schistosoma
mansoni) 		PF00850
(Hist_deacetyl) 		3 TYR A 182
ASP A 156
HIS A 142
 None
None
B3N  A 700 (-3.7A)
 0.90A 3e23A-4bz7A:
2.9		 3e23A-4bz7A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		3 TYR A 160
ASP A 117
HIS A 131
 None
 0.85A 3e23A-4c60A:
undetectable		 3e23A-4c60A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		3 TYR A 112
ASP A  30
HIS A 117
 CIT  A1589 (-4.6A)
None
CIT  A1589 (-4.3A)
 0.92A 3e23A-4conA:
undetectable		 3e23A-4conA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		3 TYR A 956
ASP A 949
HIS A 944
 None
 0.78A 3e23A-4gl9A:
undetectable		 3e23A-4gl9A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 TYR A 335
ASP A 115
HIS A 462
 None
None
PXM  A 609 (-3.8A)
 0.87A 3e23A-4ha6A:
2.1		 3e23A-4ha6A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 929
ASP A 922
HIS A 917
 None
 0.90A 3e23A-4hviA:
undetectable		 3e23A-4hviA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqb PROTEIN H03A11.1

(Caenorhabditis
elegans) 		PF06702
(Fam20C) 		3 TYR A 275
ASP A 366
HIS A 206
 None
MN  A 606 (-4.5A)
None
 0.84A 3e23A-4kqbA:
undetectable		 3e23A-4kqbA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Burkholderia
cenocepacia) 		PF01041
(DegT_DnrJ_EryC1) 		3 TYR A 324
ASP A 158
HIS A 184
 EDO  A 403 ( 4.0A)
EDO  A 403 (-3.6A)
CIT  A 401 (-4.0A)
 0.89A 3e23A-4lc3A:
1.9		 3e23A-4lc3A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mup AMIDOHYDROLASE

(Agrobacterium
fabrum) 		PF04909
(Amidohydro_2) 		3 TYR A 208
ASP A 255
HIS A  27
 None
 0.93A 3e23A-4mupA:
undetectable		 3e23A-4mupA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A

(Ustilago maydis) 		PF03664
(Glyco_hydro_62) 		3 TYR A 296
ASP A 258
HIS A 261
 None
None
CA  A 401 (-3.6A)
 0.88A 3e23A-4n2rA:
undetectable		 3e23A-4n2rA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nur PSDSA

(Pseudomonas sp.
S9) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 TYR A 246
ASP A 144
HIS A 194
 None
 0.91A 3e23A-4nurA:
undetectable		 3e23A-4nurA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8o ALPHA-L-ARABINOFURAN
OSIDASE

(Streptomyces
thermoviolaceus) 		PF03664
(Glyco_hydro_62) 		3 TYR A 349
ASP A 312
HIS A 315
 None
None
CA  A 401 ( 3.7A)
 0.90A 3e23A-4o8oA:
undetectable		 3e23A-4o8oA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		3 TYR A 184
ASP A 130
HIS A 164
 None
 0.88A 3e23A-4oraA:
undetectable		 3e23A-4oraA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS

(Escherichia
coli) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 TYR A 234
ASP A 132
HIS A 182
 None
None
SO4  A 701 (-4.0A)
 0.91A 3e23A-4pdxA:
undetectable		 3e23A-4pdxA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE

(Leishmania
major) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 TYR A 265
ASP A 260
HIS A 223
 None
 0.94A 3e23A-4qg5A:
undetectable		 3e23A-4qg5A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlj BETA-GLUCOSIDASE 7

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 TYR A 468
ASP A 403
HIS A 462
 CTT  A1002 (-3.8A)
None
None
 0.92A 3e23A-4qljA:
undetectable		 3e23A-4qljA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
fructosivorans) 		PF00374
(NiFeSe_Hases) 		3 TYR Q 277
ASP Q 198
HIS Q 188
 None
 0.83A 3e23A-4upeQ:
undetectable		 3e23A-4upeQ:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		3 TYR A 294
ASP A  18
HIS A 329
 None
None
ZN  A1576 (-3.1A)
 0.88A 3e23A-4upiA:
undetectable		 3e23A-4upiA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 TYR A 292
ASP A  14
HIS A 327
 None
None
ZN  A1553 (-3.2A)
 0.90A 3e23A-4uplA:
undetectable		 3e23A-4uplA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh3 N-ACETYLHEXOSAMINE
1-KINASE

(Bifidobacterium
longum) 		PF01636
(APH) 		3 TYR A 317
ASP A 158
HIS A 150
 None
 0.91A 3e23A-4wh3A:
undetectable		 3e23A-4wh3A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		3 TYR A  55
ASP A 113
HIS A 256
 FAD  A 401 (-4.0A)
None
FAD  A 401 (-3.4A)
 0.85A 3e23A-4xdtA:
undetectable		 3e23A-4xdtA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd6 HALOHYDRIN EPOXIDASE
B

(Corynebacterium
sp.) 		PF13561
(adh_short_C2) 		3 TYR A  19
ASP A 199
HIS A 162
 None
 0.92A 3e23A-4zd6A:
4.1		 3e23A-4zd6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 TYR A 196
ASP A 320
HIS A 161
 None
 0.92A 3e23A-5a05A:
4.2		 3e23A-5a05A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeu BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Paraburkholderia
xenovorans) 		PF00866
(Ring_hydroxyl_B) 		3 TYR B  56
ASP B 154
HIS B 112
 None
 0.71A 3e23A-5aeuB:
undetectable		 3e23A-5aeuB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		3 TYR A 200
ASP A 584
HIS A 545
 None
 0.95A 3e23A-5clwA:
undetectable		 3e23A-5clwA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czl GLUCANASE

(Raoultella
ornithinolytica) 		PF01270
(Glyco_hydro_8) 		3 TYR A 160
ASP A  97
HIS A  36
 None
 0.95A 3e23A-5czlA:
undetectable		 3e23A-5czlA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF03415
(Peptidase_C11) 		3 TYR A  77
ASP A  75
HIS A 135
 None
NA  A 401 ( 3.0A)
None
 0.87A 3e23A-5dynA:
undetectable		 3e23A-5dynA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy3 GLUCANASE

(Klebsiella
pneumoniae) 		PF01270
(Glyco_hydro_8) 		3 TYR A 175
ASP A 112
HIS A  51
 None
 0.90A 3e23A-5gy3A:
undetectable		 3e23A-5gy3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx0 UNCHARACTERIZED
PROTEIN DFER_1899

(Dyadobacter
fermentans) 		PF13088
(BNR_2) 		3 TYR A 381
ASP A 123
HIS A 309
 None
ACT  A 402 (-2.9A)
None
 0.91A 3e23A-5hx0A:
undetectable		 3e23A-5hx0A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1u NAD(P)H:FLAVIN
OXIDOREDUCTASE SYE4

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		3 TYR A 240
ASP A 190
HIS A 269
 TNF  A 402 (-4.5A)
None
None
 0.91A 3e23A-5k1uA:
undetectable		 3e23A-5k1uA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1

(Escherichia
coli) 		PF00884
(Sulfatase) 		3 TYR A 431
ASP A 251
HIS A 466
 None
None
ZN  A 601 (-3.1A)
 0.92A 3e23A-5k4pA:
undetectable		 3e23A-5k4pA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		3 TYR A  62
ASP A 315
HIS A 402
 None
 0.88A 3e23A-5karA:
undetectable		 3e23A-5karA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvh BACCELL_00856

(Bacteroides
cellulosilyticus) 		PF15892
(BNR_4) 		3 TYR A 232
ASP A 203
HIS A 302
 None
 0.87A 3e23A-5mvhA:
undetectable		 3e23A-5mvhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2

(Escherichia
coli) 		PF00884
(Sulfatase) 		3 TYR A 431
ASP A 251
HIS A 466
 None
None
ZN  A 602 (-3.1A)
 0.91A 3e23A-5mx9A:
2.1		 3e23A-5mx9A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80

(Chlamydomonas
reinhardtii) 		no annotation 3 TYR A 114
ASP A 193
HIS A 199
 GOL  A 802 ( 4.4A)
None
GOL  A 802 (-3.7A)
 0.97A 3e23A-5n4aA:
undetectable		 3e23A-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 3 TYR A 815
ASP A 471
HIS A 199
 MGD  A2001 (-3.4A)
None
MGD  A2001 (-4.5A)
 0.89A 3e23A-5nqdA:
undetectable		 3e23A-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 3 TYR A 386
ASP A 314
HIS A 344
 None
 0.83A 3e23A-5ot1A:
undetectable		 3e23A-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN

(Thermoactinomyces
vulgaris) 		PF00668
(Condensation) 		3 TYR A1017
ASP A1022
HIS A1169
 None
 0.84A 3e23A-5t3eA:
undetectable		 3e23A-5t3eA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		3 TYR A 322
ASP A  43
HIS A 353
 None
None
ZN  A 601 (-3.2A)
 0.89A 3e23A-5tj3A:
undetectable		 3e23A-5tj3A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00849
(PseudoU_synth_2) 		3 TYR A  99
ASP A  67
HIS A  64
 GOL  A 306 (-3.8A)
SO4  A 301 (-4.5A)
None
 0.97A 3e23A-5vbbA:
undetectable		 3e23A-5vbbA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi6 HISTONE DEACETYLASE
8

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 TYR A 174
ASP A 157
HIS A 143
 None
None
EDO  A 410 (-4.4A)
 0.89A 3e23A-5vi6A:
1.6		 3e23A-5vi6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd7 3,6-ANHYDRO-ALPHA-L-
GALACTONATE
CYCLOISOMERASE

(Vibrio sp. EJY3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A 201
ASP A 198
HIS A  29
 None
MG  A 402 (-2.9A)
None
 0.97A 3e23A-5xd7A:
2.4		 3e23A-5xd7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN

(Escherichia
coli) 		no annotation 3 TYR A 429
ASP A 249
HIS A 464
 None
None
ZN  A 601 (-3.2A)
 0.97A 3e23A-5xnuA:
2.1		 3e23A-5xnuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		3 TYR A 124
ASP A 176
HIS A 146
 None
 0.94A 3e23A-5y7oA:
undetectable		 3e23A-5y7oA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR

(Desulfovibrio
vulgaris;
Homo sapiens) 		no annotation 3 TYR A  77
ASP A  10
HIS A 275
 9ER  A1201 (-4.5A)
None
9ER  A1201 (-4.5A)
 0.84A 3e23A-5zkpA:
undetectable		 3e23A-5zkpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 3 TYR A 357
ASP A 425
HIS A 327
 FAD  A 501 (-4.3A)
None
FAD  A 501 (-4.5A)
 0.96A 3e23A-6bz0A:
2.9		 3e23A-6bz0A:
undetectable