SIMILAR PATTERNS OF AMINO ACIDS FOR 3E22_B_LOCB700

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		5 LEU A 222
LEU A 235
ALA A 234
ALA A 274
LYS A 277
 None
 1.09A 3e22B-1c3rA:
4.0		 3e22B-1c3rA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g65 PROTEASOME COMPONENT
PUP3

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 ALA I 158
LEU I 160
MET I 191
ALA I 173
VAL I 175
 None
 1.29A 3e22B-1g65I:
undetectable		 3e22B-1g65I:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ouu HEMOGLOBIN I

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		5 LEU A  77
ALA A 136
LEU A 137
ALA A  66
LYS A  69
 None
None
HEM  A 143 (-4.7A)
HEM  A 143 ( 3.9A)
None
 1.31A 3e22B-1ouuA:
undetectable		 3e22B-1ouuA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 LEU A 143
LEU A 136
ALA A 139
LEU A  79
ALA A 110
 None
 0.99A 3e22B-1rw9A:
undetectable		 3e22B-1rw9A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN

(Shigella
flexneri) 		PF02578
(Cu-oxidase_4) 		5 LEU A 153
LEU A 130
ALA A 198
LEU A 202
VAL A 123
 None
 1.31A 3e22B-1u05A:
undetectable		 3e22B-1u05A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 382
LEU A 366
ALA A 383
ALA A  97
VAL A 281
 None
 1.27A 3e22B-1ulqA:
undetectable		 3e22B-1ulqA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN

(Caulobacter
vibrioides) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		5 LEU A 244
ALA A 114
ASN A 249
ALA A 230
VAL A 232
 None
 1.26A 3e22B-1w25A:
4.3		 3e22B-1w25A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc6 COAT PROTEIN

(Brome mosaic
virus) 		no annotation 5 LEU A 171
LEU A  73
LEU A 152
ASN A 151
VAL A  87
 None
 1.21A 3e22B-1yc6A:
undetectable		 3e22B-1yc6A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 LEU A 177
ALA A  18
LEU A  20
VAL A   5
LYS A   1
 None
 1.14A 3e22B-1yrwA:
3.5		 3e22B-1yrwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zso HYPOTHETICAL PROTEIN

(Plasmodium
falciparum) 		PF05907
(DUF866) 		5 LEU A 151
LEU A  12
ALA A  10
ASN A  89
VAL A 117
 None
 1.29A 3e22B-1zsoA:
undetectable		 3e22B-1zsoA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III

(Homo sapiens) 		PF05822
(UMPH-1) 		5 LEU A 225
LEU A 282
ALA A 278
ASN A 137
VAL A 149
 None
 1.27A 3e22B-2cn1A:
4.7		 3e22B-2cn1A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III

(Homo sapiens) 		PF05822
(UMPH-1) 		5 LEU A 282
ALA A 278
LEU A 275
ASN A 137
VAL A 149
 None
 1.30A 3e22B-2cn1A:
4.7		 3e22B-2cn1A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx7 STEROL CARRIER
PROTEIN 2

(Thermus
thermophilus) 		PF02036
(SCP2) 		5 LEU A 102
ALA A  96
LEU A  94
ALA A 119
VAL A 123
 None
 0.93A 3e22B-2cx7A:
undetectable		 3e22B-2cx7A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 CYH A 758
LEU A 783
ALA A 754
LEU A 752
VAL A 579
 None
 1.25A 3e22B-2fgeA:
undetectable		 3e22B-2fgeA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fo1 LIN-12 PROTEIN

(Caenorhabditis
elegans) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU E1113
LEU E1100
ALA E1061
LEU E1057
ALA E1089
 None
 1.27A 3e22B-2fo1E:
undetectable		 3e22B-2fo1E:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6b RAS-RELATED PROTEIN
RAB-26

(Homo sapiens) 		PF00071
(Ras) 		5 LEU A  80
LEU A 115
LEU A 141
MET A 173
ALA A 217
 None
 1.26A 3e22B-2g6bA:
4.3		 3e22B-2g6bA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2m COMM
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF17221
(COMMD1_N) 		6 LEU A  39
LEU A  35
ALA A  18
LEU A  15
MET A  55
VAL A  43
 None
 1.37A 3e22B-2h2mA:
undetectable		 3e22B-2h2mA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i44 SERINE-THREONINE
PHOSPHATASE 2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		5 LEU A  86
ALA A 119
LEU A 116
ALA A 153
VAL A  54
 None
 1.18A 3e22B-2i44A:
undetectable		 3e22B-2i44A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6e HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02621
(VitK2_biosynth) 		5 LEU A 220
LEU A  34
ASN A  63
ALA A  19
VAL A  40
 None
 1.07A 3e22B-2i6eA:
undetectable		 3e22B-2i6eA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iml HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF04289
(DUF447) 		5 LEU A  47
LEU A 114
ALA A  45
ASN A  13
ALA A  64
 FMN  A 200 (-4.5A)
None
None
None
None
 1.19A 3e22B-2imlA:
undetectable		 3e22B-2imlA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00749
(tRNA-synt_1c) 		5 LEU A 436
LEU A 417
ALA A 413
LEU A 410
ALA A 454
 None
 1.29A 3e22B-2ja2A:
undetectable		 3e22B-2ja2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 324
LEU A 239
ALA A 293
LEU A 297
ASN A 300
ALA A 222
 None
 1.28A 3e22B-2jiiA:
undetectable		 3e22B-2jiiA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l10 TALIN-1

(Mus musculus) 		PF08913
(VBS) 		5 LEU A1249
ALA A1253
LEU A1256
ALA A1212
VAL A1216
 None
 1.25A 3e22B-2l10A:
undetectable		 3e22B-2l10A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 204
LEU A 166
ALA A 170
VAL A 197
LYS A 184
 None
 1.19A 3e22B-2og9A:
3.1		 3e22B-2og9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfm ADENYLOSUCCINATE
LYASE

(Bacillus
anthracis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 LEU A 228
ALA A 318
ASN A 323
MET A  10
ALA A 111
 None
 1.19A 3e22B-2pfmA:
undetectable		 3e22B-2pfmA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN

(Deinococcus
radiodurans) 		PF00773
(RNB) 		5 CYH A 269
LEU A 272
ALA A 223
LEU A 222
VAL A 104
 None
 1.25A 3e22B-2r7dA:
undetectable		 3e22B-2r7dA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		5 LEU A 137
ALA A 135
LYS A 281
LEU A 278
MET A 290
 None
 1.11A 3e22B-2r7mA:
undetectable		 3e22B-2r7mA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uz0 TRIBUTYRIN ESTERASE

(Streptococcus
pneumoniae) 		PF00756
(Esterase) 		5 LEU A 146
ALA A 211
LYS A 213
LEU A 215
ALA A 185
 None
 1.25A 3e22B-2uz0A:
2.8		 3e22B-2uz0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va8 SKI2-TYPE HELICASE

(Sulfolobus
solfataricus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A  44
ALA A  31
LYS A  34
ASN A  40
VAL A 143
 None
 1.23A 3e22B-2va8A:
undetectable		 3e22B-2va8A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy POTENTIAL
COPPER-TRANSPORTING
ATPASE

(Bacillus
subtilis) 		PF00403
(HMA) 		5 LEU A  64
LEU A  57
ALA A  60
ALA A  34
VAL A  43
 None
 1.19A 3e22B-2voyA:
undetectable		 3e22B-2voyA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5r HYPOTHETICAL PROTEIN
ORF126

(Pyrobaculum
spherical virus) 		no annotation 5 LEU A  61
ALA A  65
ASN A 100
ALA A  97
VAL A  41
 None
 1.08A 3e22B-2x5rA:
undetectable		 3e22B-2x5rA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1w IRON(II) TRANSPORT
PROTEIN B

(Thermotoga
maritima) 		PF02421
(FeoB_N) 		5 LEU A  76
LEU A  70
ALA A  86
ALA A  95
VAL A  98
 None
 1.31A 3e22B-3a1wA:
3.9		 3e22B-3a1wA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 CYH A 596
LEU A 600
ALA A 572
LEU A 569
ALA A 546
 None
 1.04A 3e22B-3b2rA:
undetectable		 3e22B-3b2rA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b64 MACROPHAGE MIGRATION
INHIBITORY
FACTOR-LIKE PROTEIN

(Leishmania
major) 		PF01187
(MIF) 		5 LEU A  19
ALA A  83
LYS A  86
ALA A  58
VAL A  60
 None
 1.09A 3e22B-3b64A:
undetectable		 3e22B-3b64A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 CYH A 596
LEU A 600
ALA A 572
LEU A 569
ALA A 546
 None
 1.05A 3e22B-3bjcA:
undetectable		 3e22B-3bjcA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjz PHOSPHOHEPTOSE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF13580
(SIS_2) 		5 LEU A  25
LEU A 184
ALA A 180
ALA A 143
VAL A 161
 None
 1.27A 3e22B-3bjzA:
4.3		 3e22B-3bjzA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		5 LEU A 153
LYS A 125
ASN A 126
ALA A 240
VAL A 242
 None
 1.19A 3e22B-3brsA:
undetectable		 3e22B-3brsA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E

(Syntrophus
aciditrophicus) 		PF02663
(FmdE) 		5 LEU A 144
ALA A  39
LYS A  41
LEU A  43
VAL A 147
 None
 1.28A 3e22B-3d00A:
undetectable		 3e22B-3d00A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		5 LEU A  49
LEU A  67
ALA A  47
LEU A   8
VAL A  56
 None
 1.20A 3e22B-3ddnA:
2.5		 3e22B-3ddnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fij LIN1909 PROTEIN

(Listeria
innocua) 		PF07722
(Peptidase_C26) 		5 LEU A  65
LEU A 105
ALA A 104
ALA A 124
VAL A 121
 None
 1.11A 3e22B-3fijA:
undetectable		 3e22B-3fijA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvr ACETYL XYLAN
ESTERASE

(Bacillus
pumilus) 		PF05448
(AXE1) 		5 LEU A 284
ALA A 254
LEU A 250
ALA A 202
VAL A 200
 None
 0.93A 3e22B-3fvrA:
2.9		 3e22B-3fvrA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG

(Helicobacter
pylori) 		PF00072
(Response_reg) 		5 LEU A  64
ALA A  37
LYS A  40
LEU A  41
ASN A  44
 None
 1.24A 3e22B-3h1gA:
5.3		 3e22B-3h1gA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im9 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Staphylococcus
aureus) 		PF00698
(Acyl_transf_1) 		5 LEU A 135
ALA A 186
LYS A 182
LEU A 184
VAL A 167
 None
 1.29A 3e22B-3im9A:
undetectable		 3e22B-3im9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j23 CAPSID PROTEIN VP3

(Enterovirus A) 		PF00073
(Rhv) 		5 LEU C  53
ALA C 216
ASN C  56
ALA C  84
VAL C 194
 None
 1.28A 3e22B-3j23C:
undetectable		 3e22B-3j23C:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		6 CYH A 222
LEU A 223
LEU A 202
ALA A 226
ASN A 173
VAL A 209
 None
None
None
None
NAD  A 400 ( 4.8A)
None
 1.39A 3e22B-3jzdA:
3.4		 3e22B-3jzdA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 LEU A 423
LEU A 416
ALA A 437
ASN A 400
VAL A 338
 None
 1.21A 3e22B-3k5wA:
3.0		 3e22B-3k5wA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 LEU A 324
ALA A 320
ALA A  46
VAL A  48
LYS A  16
 None
 1.31A 3e22B-3o8lA:
undetectable		 3e22B-3o8lA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY

(Corynebacterium
glutamicum) 		PF00294
(PfkB) 		5 CYH A 205
LEU A 171
ALA A 208
ALA A 229
VAL A 231
 None
 0.98A 3e22B-3pl2A:
5.1		 3e22B-3pl2A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro2 G-PROTEIN-SIGNALING
MODULATOR 2

(Mus musculus) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		5 LEU A 248
LEU A 241
ALA A 244
ASN A 203
ALA A 217
 None
 1.27A 3e22B-3ro2A:
undetectable		 3e22B-3ro2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 704
LEU A 751
ALA A 649
VAL A 633
LYS A 635
 None
 1.20A 3e22B-3zfxA:
undetectable		 3e22B-3zfxA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zny CTX-M-12A ENZYME

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		5 LEU A 138
ALA A 126
LEU A 127
ASN A 214
MET A 211
 None
 1.06A 3e22B-3znyA:
undetectable		 3e22B-3znyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxu CTF19

(Kluyveromyces
lactis) 		no annotation 5 LEU B 132
LEU B 158
MET B 154
ALA B 181
VAL B 185
 None
 1.10A 3e22B-3zxuB:
undetectable		 3e22B-3zxuB:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxu CTF19

(Kluyveromyces
lactis) 		no annotation 5 LEU B 133
LEU B 158
ALA B 140
MET B 154
ALA B 172
 None
 1.26A 3e22B-3zxuB:
undetectable		 3e22B-3zxuB:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amg SNOGD

(Streptomyces
nogalater) 		PF06722
(DUF1205) 		5 LEU A 217
LEU A 291
ALA A 290
ASN A 212
VAL A 283
 None
 1.20A 3e22B-4amgA:
4.8		 3e22B-4amgA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg5 BBA65

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		5 LEU A 224
ALA A 136
LEU A 140
ASN A 143
MET A 144
 None
 1.07A 3e22B-4bg5A:
undetectable		 3e22B-4bg5A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1j GLYCEROL KINASE

(Sinorhizobium
meliloti) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 182
ALA A 173
LEU A 166
ASN A 169
VAL A 231
 None
 1.29A 3e22B-4e1jA:
undetectable		 3e22B-4e1jA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 LEU A 250
ALA A 340
ASN A 347
MET A 348
VAL A  26
 None
 1.27A 3e22B-4fidA:
3.4		 3e22B-4fidA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		5 LEU A 350
ALA A 328
LEU A 304
ALA A 321
VAL A 315
 None
 1.26A 3e22B-4gr4A:
undetectable		 3e22B-4gr4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr5 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		5 LEU A 350
ALA A 328
LEU A 304
ALA A 321
VAL A 315
 None
 1.27A 3e22B-4gr5A:
undetectable		 3e22B-4gr5A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		5 CYH B 225
ALA B 245
LEU B 194
ALA B 179
VAL B 177
 None
None
None
None
CIT  B 901 (-4.1A)
 1.08A 3e22B-4k7gB:
undetectable		 3e22B-4k7gB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k8l PROLINE RACEMASE

(Ochrobactrum
anthropi) 		PF05544
(Pro_racemase) 		5 CYH A 224
ALA A 244
LEU A 194
ALA A 179
VAL A 177
 None
 1.16A 3e22B-4k8lA:
undetectable		 3e22B-4k8lA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF13646
(HEAT_2) 		5 LEU A  41
LEU A  57
ALA A  53
ALA A  83
VAL A  79
 None
 1.20A 3e22B-4l7mA:
2.6		 3e22B-4l7mA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n40 PROTEIN ECT2

(Homo sapiens) 		PF00533
(BRCT)
PF12738
(PTCB-BRCT) 		5 LEU A 124
LEU A  69
ALA A  68
ALA A  59
VAL A  98
 None
 1.30A 3e22B-4n40A:
undetectable		 3e22B-4n40A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 LEU A 666
LEU A 641
ALA A 640
ALA A 592
VAL A 676
 None
 1.21A 3e22B-4p72A:
undetectable		 3e22B-4p72A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qr8 XAA-PRO DIPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		5 LEU A 244
LEU A 220
ALA A 219
ASN A 198
ALA A 184
 None
 1.27A 3e22B-4qr8A:
undetectable		 3e22B-4qr8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rtf CHAPERONE PROTEIN
DNAK

(Mycobacterium
tuberculosis) 		PF00012
(HSP70) 		5 LEU D 224
LEU D 255
ASN D 254
ALA D 237
VAL D 209
 None
 1.16A 3e22B-4rtfD:
undetectable		 3e22B-4rtfD:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU B  27
LEU B 219
ALA B 216
VAL B  35
LYS B   9
 None
 1.04A 3e22B-4rziB:
6.1		 3e22B-4rziB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase) 		5 LEU A 386
ALA A 434
LEU A 438
ALA A 318
LYS A 319
 None
 1.17A 3e22B-4u3tA:
undetectable		 3e22B-4u3tA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v12 MAOC LIKE DOMAIN
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		5 LEU A 242
ALA A 249
LYS A 250
ALA A 161
VAL A 165
 None
 1.23A 3e22B-4v12A:
undetectable		 3e22B-4v12A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		5 LEU A 175
LEU A  38
ALA A  37
ALA A 184
VAL A 186
 None
 1.21A 3e22B-4xdtA:
undetectable		 3e22B-4xdtA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg0 UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 LEU A 326
LEU A 368
ALA A 373
ALA A 346
VAL A 344
 None
 1.29A 3e22B-4xg0A:
undetectable		 3e22B-4xg0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		5 CYH A 164
LEU A 178
LYS A 156
LEU A 155
VAL A  83
 None
 1.26A 3e22B-4y6oA:
3.1		 3e22B-4y6oA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1p CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		5 LEU A  59
ALA A  58
LEU A 170
ASN A 168
ALA A  22
 None
 1.17A 3e22B-4z1pA:
undetectable		 3e22B-4z1pA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z23 CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		5 LEU A  59
ALA A  58
LEU A 170
ASN A 168
ALA A  22
 None
None
None
None
EDO  A 401 (-3.8A)
 1.24A 3e22B-4z23A:
undetectable		 3e22B-4z23A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Oceanimonas
doudoroffii) 		PF00171
(Aldedh) 		5 LEU A  74
ALA A 191
LEU A 188
MET A 198
VAL A 108
 None
 1.13A 3e22B-4zz7A:
undetectable		 3e22B-4zz7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cek TRIBBLES HOMOLOG 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 CYH A 119
LEU A 117
LEU A  96
ALA A 108
ALA A  92
 None
 1.27A 3e22B-5cekA:
undetectable		 3e22B-5cekA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Mycobacterium
tuberculosis) 		PF02776
(TPP_enzyme_N) 		5 LEU A  25
LEU A 103
ALA A  76
ALA A   8
VAL A  12
 None
 0.94A 3e22B-5esoA:
undetectable		 3e22B-5esoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5v PRP38
ZINC FINGER
DOMAIN-CONTAINING
PROTEIN

(Chaetomium
thermophilum) 		PF03371
(PRP38)
no annotation 		5 LEU A 102
LEU A 116
ALA A 120
LEU A  92
VAL C 141
 None
 1.21A 3e22B-5f5vA:
undetectable		 3e22B-5f5vA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Clostridium sp.) 		PF13561
(adh_short_C2) 		5 LEU A  33
LEU A 240
ALA A  42
VAL A  44
LYS A  18
 None
 1.17A 3e22B-5g4lA:
6.9		 3e22B-5g4lA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6o PORPHOBILINOGEN
DEAMINASE

(Vibrio cholerae) 		no annotation 5 LEU A 244
ASN A 241
MET A 240
ALA A 267
VAL A 278
 None
 1.08A 3e22B-5h6oA:
undetectable		 3e22B-5h6oA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 386
ALA A 434
LEU A 438
ALA A 318
LYS A 319
 None
 1.18A 3e22B-5kshA:
undetectable		 3e22B-5kshA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m41 NIGRITOXINE

(Vibrio
nigripulchritudo) 		no annotation 5 LEU A 230
ALA A 263
LEU A 261
ASN A  39
ALA A 214
 None
 1.30A 3e22B-5m41A:
undetectable		 3e22B-5m41A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens) 		no annotation 5 LEU A 332
LEU A 282
ALA A  13
ALA A 161
VAL A 272
 None
 1.05A 3e22B-5mg5A:
undetectable		 3e22B-5mg5A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpt CITRININ POLYKETIDE
SYNTHASE

(Monascus
purpureus) 		PF08242
(Methyltransf_12) 		5 LEU A2089
ALA A2062
LEU A2061
MET A2002
ALA A1968
 None
 1.18A 3e22B-5mptA:
undetectable		 3e22B-5mptA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu3 CENTRAL KINETOCHORE
SUBUNIT CTF19

(Kluyveromyces
lactis) 		no annotation 5 LEU E 133
LEU E 158
ALA E 140
MET E 154
ALA E 172
 None
 1.21A 3e22B-5mu3E:
undetectable		 3e22B-5mu3E:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nji PHTHIOCEROL/PHENOLPH
THIOCEROL SYNTHESIS
POLYKETIDE SYNTHASE
TYPE I PPSC

(Mycobacterium
tuberculosis) 		PF14765
(PS-DH) 		5 LEU A1198
LEU A1132
ALA A1131
ALA A 973
VAL A1169
 None
8Z2  A1301 ( 3.8A)
None
None
None
 1.13A 3e22B-5njiA:
undetectable		 3e22B-5njiA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL

(Bos taurus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 LEU A  23
ALA A 212
LEU A 208
ALA A 198
VAL A  39
 None
 1.25A 3e22B-5nmiA:
undetectable		 3e22B-5nmiA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npu ANC27

(synthetic
construct) 		no annotation 5 LEU A   9
ALA A  10
LEU A  42
ALA A  68
VAL A  70
 None
 1.17A 3e22B-5npuA:
undetectable		 3e22B-5npuA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 731
LEU A 769
ALA A 743
VAL A 797
LYS A 742
 None
 1.31A 3e22B-5opjA:
undetectable		 3e22B-5opjA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ted LMO0488 PROTEIN

(Listeria
monocytogenes) 		no annotation 5 LEU B  95
LEU B 138
ALA B 146
LEU B 269
LYS B 273
 None
 1.30A 3e22B-5tedB:
undetectable		 3e22B-5tedB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upr TRIOSEPHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00121
(TIM) 		5 LEU A 210
LEU A 238
ALA A 237
ALA A 274
VAL A 271
 None
 1.14A 3e22B-5uprA:
undetectable		 3e22B-5uprA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29

(Chaetomium
thermophilum) 		no annotation 5 CYH A  38
LEU A  37
LEU A  51
LEU A   6
ALA A 138
 None
 1.30A 3e22B-5w8mA:
undetectable		 3e22B-5w8mA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 5 LEU A 200
ALA A 203
LYS A 163
ASN A 160
VAL A 215
 None
 1.20A 3e22B-5wlhA:
undetectable		 3e22B-5wlhA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 5 LEU A1732
LEU A1739
ALA A1847
VAL A1849
LYS A1844
 None
 1.14A 3e22B-5zalA:
undetectable		 3e22B-5zalA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao8 ARGININE--TRNA
LIGASE

(Neisseria
gonorrhoeae) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 LEU A  91
LEU A 549
ALA A 493
LEU A 497
ALA A  98
 None
 1.28A 3e22B-6ao8A:
undetectable		 3e22B-6ao8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 5 LEU A 642
LEU A 616
LEU A 574
ASN A 573
LYS A 571
 None
 1.17A 3e22B-6bf6A:
undetectable		 3e22B-6bf6A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9e CYSTEINE DESULFURASE

(Legionella
pneumophila) 		no annotation 5 LYS A 168
LEU A 169
ASN A 170
ALA A 203
VAL A 205
 None
 1.08A 3e22B-6c9eA:
undetectable		 3e22B-6c9eA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 10
N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 5 LEU A 541
LEU B  11
ASN B  13
MET B  14
ALA B   6
 None
 1.01A 3e22B-6c9mA:
undetectable		 3e22B-6c9mA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cqb CHALCONE SYNTHASE

(Piper
methysticum) 		no annotation 5 CYH A 191
LEU A 344
ALA A 222
ALA A 175
VAL A 171
 None
 1.24A 3e22B-6cqbA:
undetectable		 3e22B-6cqbA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e29 -

(-) 		no annotation 5 LEU D  92
LEU D  95
ASN D  33
ALA D  40
VAL D  48
 None
 1.08A 3e22B-6e29D:
undetectable		 3e22B-6e29D:
undetectable