SIMILAR PATTERNS OF AMINO ACIDS FOR 3DZY_D_BRLD478

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 LEU A 575
VAL A 573
LEU A 595
MET A 627
TYR A 452
 None
 1.48A 3dzyD-1j0nA:
0.0		 3dzyD-1j0nA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE

(Citrobacter
amalonaticus) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		5 SER A 300
HIS A 326
LEU A 270
VAL A 215
LEU A 211
 None
 1.17A 3dzyD-1kkrA:
0.0		 3dzyD-1kkrA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3w EP-CADHERIN

(Xenopus laevis) 		PF00028
(Cadherin) 		5 TYR A 471
LEU A 513
VAL A 511
LEU A 496
MET A 494
 None
 1.22A 3dzyD-1l3wA:
undetectable		 3dzyD-1l3wA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt3 HEAT-LABILE
ENTEROTOXIN

(Escherichia
coli) 		PF01375
(Enterotoxin_a) 		5 SER A 122
TYR A 214
VAL A  60
MET A  94
TYR A 149
 None
 1.41A 3dzyD-1lt3A:
undetectable		 3dzyD-1lt3A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5f CHOLERA ENTEROTOXIN,
A CHAIN

(Vibrio cholerae) 		PF01375
(Enterotoxin_a) 		5 SER A 122
TYR A 214
VAL A  60
MET A  94
TYR A 149
 None
 1.33A 3dzyD-1s5fA:
undetectable		 3dzyD-1s5fA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9c CRM1 PROTEIN

(Homo sapiens) 		PF08767
(CRM1_C) 		5 LEU A 785
VAL A 826
LEU A 851
MET A 804
TYR A 714
 None
 1.47A 3dzyD-1w9cA:
0.3		 3dzyD-1w9cA:
20.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 PHE A 273
CYH A 276
SER A 280
LEU A 321
LEU A 344
MET A 355
HIS A 440
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 0.92A 3dzyD-2p54A:
34.7		 3dzyD-2p54A:
51.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 273
CYH A 276
SER A 280
LEU A 347
HIS A 440
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
None
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 1.42A 3dzyD-2p54A:
34.7		 3dzyD-2p54A:
51.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE

(Homo sapiens) 		PF00368
(HMG-CoA_red) 		5 SER A 565
HIS A 752
LEU A 851
VAL A 717
MET A 728
 None
 1.49A 3dzyD-2r4fA:
0.0		 3dzyD-2r4fA:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 PHE A 282
ARG A 288
SER A 289
HIS A 323
TYR A 327
HIS A 449
TYR A 473
 MC5  A   1 (-4.4A)
None
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
None
MC5  A   1 (-3.9A)
MC5  A   1 (-4.9A)
 1.17A 3dzyD-3b0qA:
22.5		 3dzyD-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 PHE A 282
CYH A 285
SER A 289
HIS A 323
TYR A 327
LEU A 330
VAL A 339
LEU A 353
MET A 364
HIS A 449
TYR A 473
 MC5  A   1 (-4.4A)
MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.6A)
MC5  A   1 (-4.7A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.9A)
 0.62A 3dzyD-3b0qA:
22.5		 3dzyD-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 285
HIS A 323
LEU A 330
LEU A 353
HIS A 449
TYR A 473
 L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
None
L41  A 501 (-3.9A)
L41  A 501 (-4.8A)
 0.92A 3dzyD-3d5fA:
33.8		 3dzyD-3d5fA:
50.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 HIS A 323
LEU A 330
VAL A 334
HIS A 449
TYR A 473
 L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
None
L41  A 501 (-3.9A)
L41  A 501 (-4.8A)
 1.36A 3dzyD-3d5fA:
33.8		 3dzyD-3d5fA:
50.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 282
CYH A 285
HIS A 323
LEU A 330
LEU A 353
TYR A 473
 L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
None
L41  A 501 (-4.8A)
 0.92A 3dzyD-3d5fA:
33.8		 3dzyD-3d5fA:
50.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 PHE A 282
CYH A 285
HIS A 323
LEU A 356
TYR A 473
 L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
None
L41  A 501 (-4.8A)
 1.39A 3dzyD-3d5fA:
33.8		 3dzyD-3d5fA:
50.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		8 PHE D 282
CYH D 285
HIS D 323
TYR D 327
VAL D 339
LEU D 353
MET D 364
HIS D 449
 None
PLB  D 701 (-3.2A)
None
None
None
None
PLB  D 701 ( 4.8A)
None
 0.96A 3dzyD-3dzuD:
44.4		 3dzyD-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		8 PHE D 282
CYH D 285
TYR D 327
LEU D 330
VAL D 339
LEU D 353
MET D 364
HIS D 449
 None
PLB  D 701 (-3.2A)
None
PLB  D 701 ( 4.1A)
None
None
PLB  D 701 ( 4.8A)
None
 0.90A 3dzyD-3dzuD:
44.4		 3dzyD-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		8 PHE D 282
HIS D 323
TYR D 327
VAL D 339
LEU D 353
MET D 364
HIS D 449
TYR D 473
 None
None
None
None
None
PLB  D 701 ( 4.8A)
None
None
 0.89A 3dzyD-3dzuD:
44.4		 3dzyD-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		9 PHE D 282
SER D 289
TYR D 327
LEU D 330
VAL D 339
LEU D 353
MET D 364
HIS D 449
TYR D 473
 None
PLB  D 701 ( 3.9A)
None
PLB  D 701 ( 4.1A)
None
None
PLB  D 701 ( 4.8A)
None
None
 0.89A 3dzyD-3dzuD:
44.4		 3dzyD-3dzuD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn8 SYNAPTOTAGMIN-3

(Rattus
norvegicus) 		PF00168
(C2) 		5 HIS A 543
LEU A 433
VAL A 469
LEU A 500
HIS A 547
 ZN  A 700 (-3.1A)
None
None
None
None
 1.48A 3dzyD-3hn8A:
undetectable		 3dzyD-3hn8A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES10

(Plasmodium
falciparum) 		PF03501
(S10_plectin) 		5 HIS O  45
TYR O  25
LEU O  26
VAL O  66
HIS O  43
 None
 1.31A 3dzyD-3j7aO:
1.5		 3dzyD-3j7aO:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE

(Anopheles
gambiae) 		PF00294
(PfkB) 		5 LEU A  28
VAL A  23
LEU A  52
MET A  48
HIS A  45
 None
 1.23A 3dzyD-3looA:
undetectable		 3dzyD-3looA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we5 UBIQUITIN
CONJUGATING ENZYME

(Agrocybe
aegerita) 		PF00179
(UQ_con) 		5 LEU A  97
VAL A 110
LEU A  55
HIS A  91
TYR A 133
 None
 1.45A 3dzyD-3we5A:
undetectable		 3dzyD-3we5A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 TYR A 207
LEU A 232
VAL A 340
LEU A  71
MET A 214
 None
 1.16A 3dzyD-4p0vA:
1.9		 3dzyD-4p0vA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztb PROTEASE NSP2

(Chikungunya
virus) 		PF01707
(Peptidase_C9) 		5 CYH A 285
TYR A 172
LEU A 174
LEU A 253
HIS A 217
 GOL  A 401 ( 4.5A)
None
None
None
None
 1.14A 3dzyD-4ztbA:
undetectable		 3dzyD-4ztbA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztb PROTEASE NSP2

(Chikungunya
virus) 		PF01707
(Peptidase_C9) 		5 TYR A 172
LEU A 174
VAL A 158
LEU A 253
HIS A 217
 None
 1.35A 3dzyD-4ztbA:
undetectable		 3dzyD-4ztbA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		5 PHE A1469
HIS A1384
VAL A1400
LEU A1440
TYR A1487
 None
 1.29A 3dzyD-5cslA:
undetectable		 3dzyD-5cslA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g53 ADENOSINE RECEPTOR
A2A
ENGINEERED DOMAIN OF
HUMAN G ALPHA S LONG
ISOFORM

(Homo sapiens) 		PF00001
(7tm_1)
PF00503
(G-alpha) 		5 PHE A  44
HIS C 387
TYR C 391
LEU A  95
TYR A 112
 None
 1.36A 3dzyD-5g53A:
2.8		 3dzyD-5g53A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyk MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Saccharomyces
cerevisiae) 		PF10296
(MMM1) 		5 ARG A 210
LEU A 188
VAL A 194
LEU A 122
HIS A 163
 None
 1.50A 3dzyD-5gykA:
undetectable		 3dzyD-5gykA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 SER A 112
HIS A 106
TYR A 120
LEU A  56
LEU A 239
 GOL  A 401 (-3.6A)
None
None
None
None
 1.37A 3dzyD-5hc4A:
undetectable		 3dzyD-5hc4A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		5 PHE A1469
HIS A1384
VAL A1400
LEU A1440
TYR A1487
 None
 1.30A 3dzyD-5i6eA:
undetectable		 3dzyD-5i6eA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk7 PROTEIN VPR
URACIL-DNA
GLYCOSYLASE

(Homo sapiens;
Human
immunodeficiency
virus 1) 		PF00522
(VPR)
PF03167
(UDG) 		5 CYH D 157
LEU D 142
VAL D 140
HIS D 268
TYR F  47
 None
 1.43A 3dzyD-5jk7D:
undetectable		 3dzyD-5jk7D:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7k PROTEIN UNC-119
HOMOLOG A

(Homo sapiens) 		PF05351
(GMP_PDE_delta) 		5 PHE A  91
SER A 218
HIS A 165
TYR A 234
TYR A 194
 None
 1.29A 3dzyD-5l7kA:
undetectable		 3dzyD-5l7kA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES

(Corynebacterium
glutamicum) 		PF01053
(Cys_Met_Meta_PP) 		5 HIS A 261
LEU A 375
VAL A 379
LEU A 272
TYR A 205
 None
 1.38A 3dzyD-5x5hA:
undetectable		 3dzyD-5x5hA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsh PROTEIN (EPSILON
SUBUNIT)

(Escherichia
coli) 		PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N) 		4 ILE A  50
GLN A 127
ILE A  45
LEU A 128
 None
 1.21A 3dzyD-1bshA:
undetectable		 3dzyD-1bshA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 ILE A 441
GLN A 363
ILE A 432
LEU A 756
 None
 1.33A 3dzyD-1c7tA:
0.0		 3dzyD-1c7tA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ILE B 220
GLN B 244
ILE B 172
LEU B 296
 KCX  B 219 ( 3.8A)
None
KCX  B 219 ( 4.4A)
None
 0.98A 3dzyD-1e9yB:
0.0		 3dzyD-1e9yB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1huj INORGANIC
PYROPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF00719
(Pyrophosphatase) 		4 ILE A  19
GLN A  98
ILE A  68
LEU A 247
 None
 1.18A 3dzyD-1hujA:
undetectable		 3dzyD-1hujA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ILE A1253
GLN A1095
ILE A1085
LEU A1054
 None
 1.34A 3dzyD-1n5xA:
0.0		 3dzyD-1n5xA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvp TRANSCRIPTION
INITIATION FACTOR
IIA BETA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN

(Homo sapiens) 		PF02268
(TFIIA_gamma_N)
PF02751
(TFIIA_gamma_C)
PF03153
(TFIIA) 		4 ILE D  44
GLN D   4
ILE C 357
LEU D  34
 None
 1.22A 3dzyD-1nvpD:
undetectable		 3dzyD-1nvpD:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ILE A 221
GLN A 245
ILE A 208
LEU A 282
 None
 1.15A 3dzyD-1pv9A:
0.2		 3dzyD-1pv9A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qls S100C PROTEIN

(Sus scrofa) 		PF00036
(EF-hand_1)
PF01023
(S_100) 		4 ILE A  82
GLN A  76
ILE A  18
LEU A  67
 None
 1.19A 3dzyD-1qlsA:
undetectable		 3dzyD-1qlsA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 ILE A 693
GLN A 643
ILE A 670
LEU A 429
 None
 1.31A 3dzyD-1u1hA:
undetectable		 3dzyD-1u1hA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u83 PHOSPHOSULFOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF02679
(ComA) 		4 ILE A  22
GLN A 214
ILE A 168
LEU A 241
 None
PO4  A1001 ( 4.6A)
None
None
 1.07A 3dzyD-1u83A:
undetectable		 3dzyD-1u83A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, ALPHA
SUBUNIT
PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE B  93
GLN A 150
ILE B  80
LEU B  71
 None
 1.17A 3dzyD-1w85B:
0.0		 3dzyD-1w85B:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ILE A 224
GLN A 248
ILE A 211
LEU A 285
 None
 1.14A 3dzyD-1wy2A:
0.0		 3dzyD-1wy2A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		4 ILE A 262
GLN A 105
ILE A 296
LEU A 252
 None
 1.16A 3dzyD-1xszA:
undetectable		 3dzyD-1xszA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybi NON-TOXIN
HAEMAGGLUTININ HA34

(Clostridium
botulinum) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		4 ILE A  61
GLN A  30
ILE A  51
LEU A  45
 None
 1.31A 3dzyD-1ybiA:
undetectable		 3dzyD-1ybiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv9 HYDROLASE, HALOACID
DEHALOGENASE FAMILY

(Enterococcus
faecalis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ILE A 204
GLN A   6
ILE A  10
LEU A   3
 None
 1.15A 3dzyD-1yv9A:
undetectable		 3dzyD-1yv9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be1 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A 124
GLN A 306
ILE A 236
LEU A 313
 None
 1.30A 3dzyD-2be1A:
undetectable		 3dzyD-2be1A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ILE A 264
GLN A 256
ILE A 371
LEU A 271
 None
 1.13A 3dzyD-2cfmA:
undetectable		 3dzyD-2cfmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cja SERYL-TRNA
SYNTHETASE

(Methanosarcina
barkeri) 		no annotation 4 ILE A  24
GLN A  80
ILE A  91
LEU A  36
 None
 1.09A 3dzyD-2cjaA:
undetectable		 3dzyD-2cjaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crv TRANSLATION
INITIATION FACTOR
IF-2

(Mus musculus) 		no annotation 4 ILE A  97
GLN A  36
ILE A  10
LEU A  16
 None
 1.11A 3dzyD-2crvA:
undetectable		 3dzyD-2crvA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekm HYPOTHETICAL PROTEIN
ST1511

(Sulfurisphaera
tokodaii) 		PF04008
(Adenosine_kin) 		4 ILE A  47
GLN A  72
ILE A  88
LEU A  76
 None
 1.21A 3dzyD-2ekmA:
undetectable		 3dzyD-2ekmA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqf HYPOTHETICAL PROTEIN
HI0933

(Haemophilus
influenzae) 		PF03486
(HI0933_like) 		4 ILE A 220
GLN A 246
ILE A 239
LEU A  99
 None
 1.23A 3dzyD-2gqfA:
undetectable		 3dzyD-2gqfA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id0 EXORIBONUCLEASE 2

(Escherichia
coli) 		PF00575
(S1)
PF00773
(RNB)
PF08206
(OB_RNB) 		4 ILE A 477
GLN A 530
ILE A 506
LEU A 537
 None
 1.23A 3dzyD-2id0A:
undetectable		 3dzyD-2id0A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70

(Saccharomyces
cerevisiae) 		PF03081
(Exo70) 		4 ILE A 472
GLN A 470
ILE A 362
LEU A 577
 None
 1.15A 3dzyD-2pfvA:
undetectable		 3dzyD-2pfvA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'

(Sulfolobus
solfataricus) 		PF04998
(RNA_pol_Rpb1_5) 		4 ILE C 297
GLN C 304
ILE C 310
LEU C 102
 None
 1.31A 3dzyD-2pmzC:
undetectable		 3dzyD-2pmzC:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk7 GAMMA-HEMOLYSIN
COMPONENT A

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		4 ILE A 135
GLN A 139
ILE A 123
LEU A 200
 None
 1.16A 3dzyD-2qk7A:
undetectable		 3dzyD-2qk7A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 ILE G 728
GLN G 731
ILE G 717
LEU G 593
 None
 1.35A 3dzyD-2uv8G:
0.0		 3dzyD-2uv8G:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		4 ILE A 437
GLN A 298
ILE A 351
LEU A 294
 None
 1.30A 3dzyD-2vsaA:
undetectable		 3dzyD-2vsaA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxr BOTULINUM NEUROTOXIN
TYPE G

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 ILE A1245
GLN A1114
ILE A1118
LEU A1280
 None
 1.35A 3dzyD-2vxrA:
undetectable		 3dzyD-2vxrA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF07632
(DUF1593) 		4 ILE A 578
GLN A 541
ILE A 558
LEU A 716
 None
 1.29A 3dzyD-2yhgA:
undetectable		 3dzyD-2yhgA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		4 ILE A 176
GLN A 173
ILE A  96
LEU A 256
 None
 1.35A 3dzyD-3ailA:
undetectable		 3dzyD-3ailA:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ILE A 281
GLN A 286
ILE A 341
LEU A 453
 MC5  A   1 ( 4.8A)
None
MC5  A   1 (-4.5A)
MC5  A   1 (-4.2A)
 0.67A 3dzyD-3b0qA:
22.5		 3dzyD-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfi TYPE II SECRETORY
PATHWAY, PSEUDOPILIN
EPSJ

(Vibrio
vulnificus) 		PF11612
(T2SSJ) 		4 ILE B  58
GLN B  62
ILE B  89
LEU B 166
 None
 1.34A 3dzyD-3cfiB:
undetectable		 3dzyD-3cfiB:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 ILE A  28
GLN A  36
ILE A  17
LEU A  50
 None
 1.15A 3dzyD-3dm5A:
undetectable		 3dzyD-3dm5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Bacteroides
vulgatus) 		PF00891
(Methyltransf_2) 		4 ILE A 285
GLN A 256
ILE A 269
LEU A 302
 None
 1.35A 3dzyD-3dp7A:
undetectable		 3dzyD-3dp7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ILE A 516
GLN A 514
ILE A 479
LEU A 109
 None
 1.22A 3dzyD-3fw8A:
undetectable		 3dzyD-3fw8A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		4 ILE A 121
GLN A 182
ILE A 202
LEU A 129
 None
LLP  A 243 ( 4.0A)
None
None
 1.29A 3dzyD-3hvyA:
undetectable		 3dzyD-3hvyA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ILE A 969
GLN A 963
ILE A 973
LEU A 958
 None
 1.34A 3dzyD-3iayA:
undetectable		 3dzyD-3iayA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 4 ILE C 353
GLN C 267
ILE C 254
LEU C 300
 None
 1.20A 3dzyD-3j9uC:
undetectable		 3dzyD-3j9uC:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzl PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
monocytogenes) 		PF06838
(Met_gamma_lyase) 		4 ILE A 106
GLN A 165
ILE A 185
LEU A 114
 None
LLP  A 226 ( 4.1A)
None
None
 1.31A 3dzyD-3jzlA:
undetectable		 3dzyD-3jzlA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4y ISOPENTENYL
PHOSPHATE KINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase) 		4 ILE A  97
GLN A 102
ILE A  29
LEU A 138
 None
 1.30A 3dzyD-3k4yA:
undetectable		 3dzyD-3k4yA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcc CATABOLITE GENE
ACTIVATOR

(Escherichia
coli) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		4 ILE A 172
GLN A 145
ILE A 203
LEU A 137
 None
 1.08A 3dzyD-3kccA:
undetectable		 3dzyD-3kccA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxq UNCHARACTERIZED
PROTEIN VP1736

(Vibrio
parahaemolyticus) 		PF00884
(Sulfatase) 		4 ILE A 527
GLN A 321
ILE A 498
LEU A 303
 None
 1.29A 3dzyD-3lxqA:
undetectable		 3dzyD-3lxqA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Saccharomyces
cerevisiae) 		PF00443
(UCH)
PF02148
(zf-UBP) 		4 ILE A 140
GLN A 153
ILE A 217
LEU A 136
 None
 1.31A 3dzyD-3m99A:
undetectable		 3dzyD-3m99A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2t PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		4 ILE A 190
GLN A 275
ILE A 179
LEU A 185
 None
 1.28A 3dzyD-3n2tA:
undetectable		 3dzyD-3n2tA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o21 GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 ILE A 286
GLN A  28
ILE A   8
LEU A 262
 None
 1.27A 3dzyD-3o21A:
undetectable		 3dzyD-3o21A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1w RABGDI PROTEIN

(Plasmodium
falciparum) 		PF00996
(GDI) 		4 ILE A 124
GLN A 338
ILE A 347
LEU A 188
 None
 1.26A 3dzyD-3p1wA:
undetectable		 3dzyD-3p1wA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL

(Homo sapiens) 		PF00271
(Helicase_C)
PF12513
(SUV3_C) 		4 ILE A 612
GLN A 592
ILE A 655
LEU A 591
 None
 1.27A 3dzyD-3rc3A:
undetectable		 3dzyD-3rc3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3roh LEUCOTOXIN LUKEV

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		4 ILE A 165
GLN A 169
ILE A 153
LEU A 232
 None
 1.15A 3dzyD-3rohA:
undetectable		 3dzyD-3rohA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsj BONT/F

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 ILE A1023
GLN A 989
ILE A 977
LEU A1038
 None
 1.34A 3dzyD-3rsjA:
undetectable		 3dzyD-3rsjA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE A 497
GLN A 502
ILE A 342
LEU A 485
 None
 1.01A 3dzyD-3sqwA:
undetectable		 3dzyD-3sqwA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1s AUTOPHAGY PROTEIN 5
UBIQUITIN-LIKE
PROTEIN ATG12

(Saccharomyces
cerevisiae) 		PF04106
(APG5)
PF04110
(APG12) 		4 ILE A 200
GLN A 217
ILE A 232
LEU C 165
 None
 1.21A 3dzyD-3w1sA:
undetectable		 3dzyD-3w1sA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		4 ILE A   4
GLN A  47
ILE A 180
LEU A 273
 None
 1.33A 3dzyD-3wrcA:
undetectable		 3dzyD-3wrcA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN

(Thermotoga
maritima) 		PF06964
(Alpha-L-AF_C) 		4 ILE A 334
GLN A 326
ILE A  60
LEU A 293
 None
 1.21A 3dzyD-4atwA:
undetectable		 3dzyD-4atwA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 4 ILE A 500
GLN A 502
ILE A  49
LEU A 605
 None
 1.28A 3dzyD-4bb9A:
undetectable		 3dzyD-4bb9A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04054
(Not1) 		4 ILE A1935
GLN A1991
ILE A1973
LEU A1847
 None
 1.31A 3dzyD-4by6A:
undetectable		 3dzyD-4by6A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz4 COPPER-REPRESSIBLE
POLYPEPTIDE

(Methylomicrobium
album) 		no annotation 4 ILE A 147
GLN A 193
ILE A 182
LEU A 108
 None
 1.28A 3dzyD-4bz4A:
undetectable		 3dzyD-4bz4A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		4 ILE A 352
GLN A 347
ILE A 496
LEU A 372
 None
 1.31A 3dzyD-4c0tA:
undetectable		 3dzyD-4c0tA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG

(Homo sapiens) 		PF02854
(MIF4G) 		4 ILE B 170
GLN B 205
ILE B 181
LEU B 237
 None
 1.06A 3dzyD-4c9bB:
undetectable		 3dzyD-4c9bB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7r PROLINE/BETAINE
TRANSPORTER, RALF

(Legionella
pneumophila;
Rickettsia
prowazekii) 		PF01369
(Sec7) 		4 ILE A 260
GLN A 102
ILE A 294
LEU A 250
 None
 1.14A 3dzyD-4d7rA:
undetectable		 3dzyD-4d7rA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		4 ILE A 497
GLN A 502
ILE A 342
LEU A 485
 None
 0.98A 3dzyD-4db4A:
undetectable		 3dzyD-4db4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		4 ILE A 497
GLN A 502
ILE A 464
LEU A 485
 None
 1.09A 3dzyD-4db4A:
undetectable		 3dzyD-4db4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fch OUTER MEMBRANE
PROTEIN SUSE

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE) 		4 ILE A 278
GLN A 207
ILE A 183
LEU A 333
 None
 1.18A 3dzyD-4fchA:
undetectable		 3dzyD-4fchA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fem OUTER MEMBRANE
PROTEIN SUSE

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE) 		4 ILE A 278
GLN A 207
ILE A 183
LEU A 333
 None
 1.17A 3dzyD-4femA:
undetectable		 3dzyD-4femA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib2 PUTATIVE LIPOPROTEIN

([Ruminococcus]
gnavus) 		PF03180
(Lipoprotein_9) 		4 ILE A 114
GLN A  92
ILE A  51
LEU A 108
 None
 1.23A 3dzyD-4ib2A:
undetectable		 3dzyD-4ib2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI

(Escherichia
coli) 		PF13561
(adh_short_C2) 		4 ILE A  20
GLN A  26
ILE A 187
LEU A  55
 NAD  A 302 (-2.9A)
None
None
None
 1.18A 3dzyD-4jx8A:
undetectable		 3dzyD-4jx8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Neisseria
meningitidis) 		PF13561
(adh_short_C2) 		4 ILE A  24
GLN A  31
ILE A 223
LEU A 237
 None
 1.34A 3dzyD-4m87A:
undetectable		 3dzyD-4m87A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		4 ILE A 507
GLN A 512
ILE A 592
LEU A 533
 None
 1.17A 3dzyD-4n78A:
2.2		 3dzyD-4n78A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		4 ILE A 468
GLN A 496
ILE A 511
LEU A 472
 None
 1.31A 3dzyD-4nnbA:
undetectable		 3dzyD-4nnbA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00342
(PGI) 		4 ILE A 334
GLN A 319
ILE A 256
LEU A 170
 None
 1.17A 3dzyD-4qfhA:
1.3		 3dzyD-4qfhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7a HISTONE-BINDING
PROTEIN RBBP4

(Homo sapiens) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		4 ILE B 390
GLN B  48
ILE B 377
LEU B  50
 None
 1.29A 3dzyD-4r7aB:
undetectable		 3dzyD-4r7aB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqk LECTIN 2

(Agrocybe
aegerita) 		PF13517
(VCBS) 		4 ILE A 188
GLN A   8
ILE A 124
LEU A 170
 None
 1.20A 3dzyD-4tqkA:
undetectable		 3dzyD-4tqkA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE A 497
GLN A 502
ILE A 342
LEU A 485
 None
 1.15A 3dzyD-4tz0A:
undetectable		 3dzyD-4tz0A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		4 ILE A 262
GLN A 247
ILE A 226
LEU A 276
 None
 1.34A 3dzyD-4wt7A:
undetectable		 3dzyD-4wt7A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzc NUCLEOPROTEIN

(Nairobi sheep
disease
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 ILE A  62
GLN A 438
ILE A  45
LEU A 444
 None
 1.17A 3dzyD-4xzcA:
0.9		 3dzyD-4xzcA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq1 GLUCOSE-6-PHOSPHATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 ILE A 505
GLN A 312
ILE A 302
LEU A 316
 None
 0.83A 3dzyD-5aq1A:
undetectable		 3dzyD-5aq1A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		4 ILE A 372
GLN A 122
ILE A 415
LEU A 124
 None
None
EDO  A 602 ( 3.7A)
None
 1.02A 3dzyD-5csuA:
undetectable		 3dzyD-5csuA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 2

(Homo sapiens) 		PF02268
(TFIIA_gamma_N)
PF02751
(TFIIA_gamma_C)
PF03153
(TFIIA) 		4 ILE D  44
GLN D   4
ILE C 357
LEU D  34
 None
 1.22A 3dzyD-5furD:
undetectable		 3dzyD-5furD:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN

(Agrobacterium
fabrum) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 ILE A 111
GLN A 242
ILE A 224
LEU A 211
 None
 1.04A 3dzyD-5i5lA:
undetectable		 3dzyD-5i5lA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb3 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		4 ILE B  83
GLN B  63
ILE B 128
LEU B  93
 None
 1.12A 3dzyD-5lb3B:
undetectable		 3dzyD-5lb3B:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liq NICKING ENDONUCLEASE
N.BSPD6I

(Bacillus sp.
(in: Bacteria)) 		PF09491
(RE_AlwI) 		4 ILE A 576
GLN A 530
ILE A 585
LEU A 491
 None
 1.15A 3dzyD-5liqA:
undetectable		 3dzyD-5liqA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw6 DDB_G0293866

(Dictyostelium
discoideum) 		no annotation 4 ILE A 177
GLN A 161
ILE A 170
LEU A  17
 None
 1.27A 3dzyD-5lw6A:
undetectable		 3dzyD-5lw6A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 ILE A 586
GLN A 599
ILE A 612
LEU A 595
 None
 1.27A 3dzyD-5m59A:
1.4		 3dzyD-5m59A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN9

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 ILE O 291
GLN O 289
ILE O 270
LEU O 334
 None
 1.32A 3dzyD-5mpdO:
undetectable		 3dzyD-5mpdO:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myu TYPE VI SECRETION
SYSTEM PROTEIN IMPC

(Vibrio cholerae) 		PF05943
(VipB) 		4 ILE A 298
GLN A 388
ILE A 190
LEU A 385
 None
 1.23A 3dzyD-5myuA:
undetectable		 3dzyD-5myuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A 146
GLN A 150
ILE A  38
LEU A 238
 None
 1.06A 3dzyD-5mzsA:
undetectable		 3dzyD-5mzsA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomyces
pombe) 		PF08638
(Med14)
PF10156
(Med17) 		4 ILE A 184
GLN A 206
ILE A 167
LEU W  51
 None
 1.26A 3dzyD-5n9jA:
undetectable		 3dzyD-5n9jA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomyces
pombe) 		PF10156
(Med17) 		4 ILE W 450
GLN W 442
ILE W 493
LEU W 439
 None
 1.24A 3dzyD-5n9jW:
undetectable		 3dzyD-5n9jW:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4

(Homo sapiens) 		no annotation 4 ILE A 141
GLN A 196
ILE A 187
LEU A 105
 ILE  A 141 ( 0.7A)
GLN  A 196 ( 0.6A)
ILE  A 187 ( 0.6A)
LEU  A 105 ( 0.6A)
 1.25A 3dzyD-5nksA:
undetectable		 3dzyD-5nksA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ILE A3811
GLN A3709
ILE A3835
LEU A3802
 None
 1.24A 3dzyD-5nugA:
undetectable		 3dzyD-5nugA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nx7 PENTALENENE SYNTHASE

(Streptomyces
clavuligerus) 		no annotation 4 ILE A 302
GLN A 214
ILE A 268
LEU A 237
 None
 1.26A 3dzyD-5nx7A:
1.9		 3dzyD-5nx7A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oi9 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Trichoplax
adhaerens) 		no annotation 4 ILE A 328
GLN A  49
ILE A  40
LEU A 123
 None
 1.32A 3dzyD-5oi9A:
undetectable		 3dzyD-5oi9A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 ILE A 151
GLN A 136
ILE A  42
LEU A 137
 None
 1.30A 3dzyD-5um6A:
0.0		 3dzyD-5um6A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbn DNA POLYMERASE
EPSILON SUBUNIT 2

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF12213
(Dpoe2NT) 		4 ILE A 412
GLN A 406
ILE A 320
LEU A 275
 None
 1.34A 3dzyD-5vbnA:
undetectable		 3dzyD-5vbnA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ILE A 200
GLN A 230
ILE A 271
LEU A 192
 None
 1.21A 3dzyD-5w4bA:
undetectable		 3dzyD-5w4bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt7 PERIOSTIN

(Homo sapiens) 		no annotation 4 ILE A  61
GLN A  68
ILE A  59
LEU A  29
 None
 1.24A 3dzyD-5wt7A:
undetectable		 3dzyD-5wt7A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029

(Streptococcus
pneumoniae) 		no annotation 4 ILE A 226
GLN A 241
ILE A 236
LEU A 193
 GOL  A 502 (-3.9A)
None
None
None
 1.30A 3dzyD-5xj1A:
undetectable		 3dzyD-5xj1A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 4 ILE A  11
GLN A 180
ILE A  32
LEU A 523
 FAD  A 701 (-4.7A)
FAD  A 701 (-4.8A)
None
None
 1.21A 3dzyD-5xmjA:
undetectable		 3dzyD-5xmjA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 ILE B 150
GLN B  73
ILE B 134
LEU B  68
 None
 1.31A 3dzyD-5y3rB:
undetectable		 3dzyD-5y3rB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7f UGGT

(Thermomyces
dupontii) 		PF01501
(Glyco_transf_8) 		4 ILE A1271
GLN A1264
ILE A1227
LEU A1384
 UDP  A2001 (-4.1A)
None
None
None
 1.31A 3dzyD-5y7fA:
undetectable		 3dzyD-5y7fA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT EXO84

(Saccharomyces
cerevisiae) 		no annotation 4 ILE H 640
GLN H 634
ILE H 668
LEU H 604
 None
 1.24A 3dzyD-5yfpH:
undetectable		 3dzyD-5yfpH:
10.97