SIMILAR PATTERNS OF AMINO ACIDS FOR 3DZY_A_9CRA463

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm0 SHIGA TOXIN A
SUBUNIT

(Shigella
dysenteriae) 		PF00161
(RIP) 		5 ILE A  20
ASN A  48
ARG A 170
LEU A 169
ALA A 166
 None
 1.06A 3dzyA-1dm0A:
undetectable		 3dzyA-1dm0A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		5 ILE A  37
ALA A  34
ASN A  12
LEU A  97
ALA A  96
 None
 0.94A 3dzyA-1e19A:
undetectable		 3dzyA-1e19A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		5 ILE A  37
ALA A  34
LEU A  97
ALA A  96
VAL A   5
 None
 0.72A 3dzyA-1e19A:
undetectable		 3dzyA-1e19A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeo HYPOTHETICAL PROTEIN
MJ1247

(Methanocaldococcus
jannaschii) 		PF01380
(SIS) 		5 ILE A  37
ALA A  40
LEU A  85
VAL A 157
LEU A 165
 None
 1.11A 3dzyA-1jeoA:
undetectable		 3dzyA-1jeoA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		5 ILE A 260
ALA A 331
GLN A 353
ALA A 390
LEU A 269
 None
 1.11A 3dzyA-1jqkA:
undetectable		 3dzyA-1jqkA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n4d VITAMIN B12
TRANSPORT PROTEIN
BTUF

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		5 ILE A  90
ALA A  94
LEU A 117
ALA A 114
VAL A 160
 None
 1.04A 3dzyA-1n4dA:
undetectable		 3dzyA-1n4dA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Mycobacterium
tuberculosis) 		PF00300
(His_Phos_1) 		5 ILE A 180
ALA A 182
PHE A 160
ARG A 159
LEU A  88
 None
 1.08A 3dzyA-1riiA:
undetectable		 3dzyA-1riiA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtg HUMAN GELATINASE A

(Homo sapiens) 		PF00045
(Hemopexin) 		5 ILE A 613
ASN A 642
LEU A 617
ALA A 570
LEU A 645
 None
None
None
CL  A   1 ( 4.1A)
None
 1.14A 3dzyA-1rtgA:
undetectable		 3dzyA-1rtgA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		5 ILE A 246
ASN A 262
PHE A 201
VAL A 224
LEU A 234
 None
 1.07A 3dzyA-1sjpA:
undetectable		 3dzyA-1sjpA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srv PROTEIN (GROEL
(HSP60 CLASS))

(Thermus
thermophilus) 		PF00118
(Cpn60_TCP1) 		5 ILE A 249
ASN A 265
PHE A 204
VAL A 227
LEU A 237
 None
 1.09A 3dzyA-1srvA:
undetectable		 3dzyA-1srvA:
15.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 342
GLN A 346
ASN A 377
ARG A 387
ALA A 398
LEU A 526
 MEI  A1001 (-3.1A)
None
None
MEI  A1001 (-3.6A)
MEI  A1001 (-3.4A)
None
 1.44A 3dzyA-1uhlA:
31.4		 3dzyA-1uhlA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ALA A 342
GLN A 346
ASN A 377
PHE A 384
ARG A 387
LEU A 397
ALA A 398
CYH A 503
LEU A 507
 MEI  A1001 (-3.1A)
None
None
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.0A)
MEI  A1001 (-4.6A)
 0.75A 3dzyA-1uhlA:
31.4		 3dzyA-1uhlA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ALA A 342
GLN A 346
PHE A 384
ARG A 387
LEU A 397
ALA A 398
VAL A 413
CYH A 503
LEU A 507
 MEI  A1001 (-3.1A)
None
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.1A)
MEI  A1001 (-4.0A)
MEI  A1001 (-4.6A)
 0.78A 3dzyA-1uhlA:
31.4		 3dzyA-1uhlA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ILE A 339
ALA A 342
GLN A 346
ASN A 377
PHE A 384
ARG A 387
LEU A 397
ALA A 398
CYH A 503
 MEI  A1001 (-3.8A)
MEI  A1001 (-3.1A)
None
None
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.0A)
 0.58A 3dzyA-1uhlA:
31.4		 3dzyA-1uhlA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ILE A 339
ALA A 342
GLN A 346
PHE A 384
ARG A 387
LEU A 397
ALA A 398
VAL A 413
CYH A 503
 MEI  A1001 (-3.8A)
MEI  A1001 (-3.1A)
None
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.1A)
MEI  A1001 (-4.0A)
 0.57A 3dzyA-1uhlA:
31.4		 3dzyA-1uhlA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		11 ILE A 242
ALA A 245
GLN A 249
ASN A 280
PHE A 287
ARG A 290
LEU A 300
ALA A 301
VAL A 316
CYH A 406
LEU A 410
 9CR  A 201 ( 4.4A)
9CR  A 201 (-3.6A)
9CR  A 201 (-4.1A)
None
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
9CR  A 201 (-4.2A)
9CR  A 201 (-3.6A)
9CR  A 201 ( 4.8A)
 0.65A 3dzyA-1xiuA:
29.1		 3dzyA-1xiuA:
62.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkp CHAPERONE PROTEIN
SYCN
CHAPERONE PROTEIN
YSCB
PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN

(Yersinia pestis) 		PF05932
(CesT)
PF07201
(HrpJ)
no annotation 		5 ILE A  49
SER B  95
ARG B  81
LEU C  73
ALA C  76
 None
 1.11A 3dzyA-1xkpA:
undetectable		 3dzyA-1xkpA:
19.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 271
GLN A 275
ASN A 306
ARG A 316
ALA A 327
LEU A 455
 9CR  A 801 (-3.6A)
9CR  A 801 (-4.7A)
None
9CR  A 801 (-2.6A)
9CR  A 801 (-3.3A)
None
 1.31A 3dzyA-1xlsA:
31.0		 3dzyA-1xlsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ILE A 268
ALA A 271
GLN A 275
ASN A 306
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 801 (-3.9A)
9CR  A 801 (-3.6A)
9CR  A 801 (-4.7A)
None
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.3A)
9CR  A 801 ( 3.7A)
9CR  A 801 (-4.7A)
 0.66A 3dzyA-1xlsA:
31.0		 3dzyA-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9j BISPHOSPHOGLYCERATE
MUTASE

(Homo sapiens) 		PF00300
(His_Phos_1) 		6 ILE A 185
ALA A 187
ARG A 164
LEU A  87
VAL A 177
LEU A 220
 None
 1.38A 3dzyA-2a9jA:
undetectable		 3dzyA-2a9jA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		5 ALA A 359
GLN A 358
LEU A 360
CYH A 300
LEU A 304
 None
 1.03A 3dzyA-2bnhA:
undetectable		 3dzyA-2bnhA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE

(Oryza sativa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ILE A 155
ALA A 189
LEU A 192
VAL A 142
LEU A 146
 None
None
None
None
CSO  A 145 ( 3.5A)
 1.10A 3dzyA-2cvoA:
undetectable		 3dzyA-2cvoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B

(Pyrococcus
horikoshii) 		PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 ASN A  54
PHE A  88
LEU A  91
ALA A  90
VAL A 209
 None
 1.08A 3dzyA-2dplA:
undetectable		 3dzyA-2dplA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ILE A  68
ALA A  67
ASN A 168
PHE A  42
ALA A 177
 None
 1.02A 3dzyA-2fuvA:
undetectable		 3dzyA-2fuvA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv2 RCD1 REQUIRED FOR
CELL
DIFFERENTIATION1
HOMOLOG

(Homo sapiens) 		PF04078
(Rcd1) 		5 ALA A  85
GLN A  82
LEU A 130
ALA A 129
LEU A  51
 None
 0.73A 3dzyA-2fv2A:
undetectable		 3dzyA-2fv2A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb3 ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 ALA A 255
ARG A 262
LEU A 258
ALA A 259
VAL A 136
 None
 1.04A 3dzyA-2gb3A:
undetectable		 3dzyA-2gb3A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggm CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 ILE A  33
ALA A  36
ASN A  85
LEU A  60
ALA A  56
 None
 1.07A 3dzyA-2ggmA:
undetectable		 3dzyA-2ggmA:
14.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A  85
SER A  91
PHE A  92
ARG A  95
ALA A 106
VAL A 121
CYH A 211
 None
 0.95A 3dzyA-2gl8A:
25.8		 3dzyA-2gl8A:
48.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 SER A  91
PHE A  92
ARG A  95
LEU A 105
ALA A 106
VAL A 121
CYH A 211
 None
 0.93A 3dzyA-2gl8A:
25.8		 3dzyA-2gl8A:
48.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3f GLYCOLIPID
TRANSFER-LIKE
PROTEIN

(Galdieria
sulphuraria) 		PF08718
(GLTP) 		5 ILE A 187
LEU A  97
ALA A  96
VAL A  24
LEU A 180
 None
 1.12A 3dzyA-2i3fA:
undetectable		 3dzyA-2i3fA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kt1 PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA

(Homo sapiens) 		no annotation 5 ALA A  37
LEU A  38
ALA A  36
VAL A  75
LEU A  23
 None
 1.11A 3dzyA-2kt1A:
undetectable		 3dzyA-2kt1A:
10.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		6 ASN A 252
PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 1.23A 3dzyA-2nxxA:
23.5		 3dzyA-2nxxA:
33.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00342
(PGI) 		5 ILE A 255
ALA A 257
LEU A 299
VAL A 184
LEU A 229
 None
 1.12A 3dzyA-2o2cA:
undetectable		 3dzyA-2o2cA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obh CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 ILE A  33
ALA A  36
ASN A  85
LEU A  60
ALA A  56
 None
 1.08A 3dzyA-2obhA:
undetectable		 3dzyA-2obhA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovl PUTATIVE RACEMASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 210
ASN A 199
LEU A 214
ALA A 211
LEU A 143
 None
NA  A 400 (-3.8A)
None
None
None
 1.09A 3dzyA-2ovlA:
undetectable		 3dzyA-2ovlA:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis) 		PF00104
(Hormone_recep) 		7 ASN A 181
SER A 187
PHE A 188
ARG A 191
ALA A 202
VAL A 217
CYH A 307
 None
 0.96A 3dzyA-2q60A:
25.9		 3dzyA-2q60A:
43.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8w POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
acinosa) 		PF00161
(RIP) 		5 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 1.04A 3dzyA-2q8wA:
undetectable		 3dzyA-2q8wA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A  69
ALA A 103
GLN A 102
VAL A 387
LEU A  38
 None
 1.03A 3dzyA-2qdeA:
undetectable		 3dzyA-2qdeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca) 		PF04672
(Methyltransf_19) 		5 ILE A 160
PHE A 154
LEU A 185
ALA A 186
VAL A 136
 None
None
None
None
SAM  A 400 (-3.8A)
 1.05A 3dzyA-2qe6A:
undetectable		 3dzyA-2qe6A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz8 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN

(Mycobacterium
tuberculosis) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		5 ILE A 125
ALA A 129
SER A 105
LEU A  88
ALA A  84
 None
 1.06A 3dzyA-2qz8A:
undetectable		 3dzyA-2qz8A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtn EST1E

(Butyrivibrio
proteoclasticus) 		PF08386
(Abhydrolase_4)
PF12146
(Hydrolase_4) 		5 ILE A 134
ALA A 138
GLN A 174
LEU A 143
LEU A 113
 None
 1.11A 3dzyA-2wtnA:
undetectable		 3dzyA-2wtnA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris) 		PF13432
(TPR_16)
PF13844
(Glyco_transf_41) 		5 ALA A 549
PHE A 228
LEU A 231
ALA A 230
LEU A 328
 None
 1.02A 3dzyA-2xgoA:
undetectable		 3dzyA-2xgoA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris) 		PF13432
(TPR_16)
PF13844
(Glyco_transf_41) 		5 ALA A 549
PHE A 228
LEU A 231
ALA A 230
VAL A 310
 None
 1.11A 3dzyA-2xgoA:
undetectable		 3dzyA-2xgoA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywv PHOSPHORIBOSYLAMINOI
MIDAZOLE
SUCCINOCARBOXAMIDE
SYNTHETASE

(Geobacillus
kaustophilus) 		PF01259
(SAICAR_synt) 		5 ILE A 189
ALA A 151
LEU A 152
ALA A 150
VAL A  85
 None
None
None
None
ADP  A 600 (-4.0A)
 1.13A 3dzyA-2ywvA:
undetectable		 3dzyA-2ywvA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am6 RHODOPSIN-2

(Acetabularia
acetabulum) 		PF01036
(Bac_rhodopsin) 		5 ILE A  44
ALA A  47
VAL A  95
CYH A 218
LEU A 219
 None
None
None
None
CLR  A 401 ( 4.6A)
 1.04A 3dzyA-3am6A:
undetectable		 3dzyA-3am6A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		5 ALA A 314
LEU A 256
ALA A 255
VAL A 301
LEU A 348
 None
 1.07A 3dzyA-3ce9A:
undetectable		 3dzyA-3ce9A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPK

(Escherichia
coli) 		PF03934
(T2SSK) 		5 ILE K 218
ALA K 221
LEU K 119
ALA K 118
LEU K 271
 None
 1.12A 3dzyA-3ci0K:
undetectable		 3dzyA-3ci0K:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER

(Vibrio
parahaemolyticus) 		PF00474
(SSF) 		5 ILE A 287
ALA A 291
ASN A 525
LEU A  95
ALA A  92
 None
 0.93A 3dzyA-3dh4A:
undetectable		 3dzyA-3dh4A:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		12 ILE A 268
ALA A 271
GLN A 275
ASN A 306
SER A 312
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A7223 (-3.9A)
9CR  A7223 (-3.5A)
9CR  A7223 (-4.6A)
9CR  A7223 (-3.9A)
9CR  A7223 ( 4.0A)
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
9CR  A7223 ( 4.5A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
 0.67A 3dzyA-3dzuA:
34.1		 3dzyA-3dzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 ILE A 268
ALA A 272
SER A 312
PHE A 313
VAL A 342
 9CR  A7223 (-3.9A)
9CR  A7223 (-4.2A)
9CR  A7223 ( 4.0A)
9CR  A7223 (-4.5A)
9CR  A7223 ( 4.5A)
 1.13A 3dzyA-3dzuA:
34.1		 3dzyA-3dzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Kluyveromyces
lactis) 		PF01408
(GFO_IDH_MocA) 		5 ILE A 106
GLN A  83
PHE A  81
VAL A 121
LEU A 145
 None
 0.92A 3dzyA-3e1kA:
undetectable		 3dzyA-3e1kA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmo ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD) 		5 ILE B 295
ALA B 122
GLN B 119
ASN B  73
ALA B 147
 None
None
ADP  B 301 (-3.2A)
None
None
 1.12A 3dzyA-3fmoB:
undetectable		 3dzyA-3fmoB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmp ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD) 		5 ILE B 295
ALA B 122
GLN B 119
ASN B  73
ALA B 147
 None
None
ADP  B 480 (-3.3A)
None
None
 1.11A 3dzyA-3fmpB:
undetectable		 3dzyA-3fmpB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2

(Phytolacca
dioica) 		PF00161
(RIP) 		5 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 1.00A 3dzyA-3h5kA:
undetectable		 3dzyA-3h5kA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE A  47
ALA A  50
LEU B  20
ALA B  19
LEU A  87
 None
 0.78A 3dzyA-3hveA:
undetectable		 3dzyA-3hveA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE B  47
ALA B  50
LEU A  20
ALA A  19
LEU B  87
 None
 0.94A 3dzyA-3hveB:
undetectable		 3dzyA-3hveB:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k11 PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		5 ILE A 228
ALA A 232
GLN A 233
LEU A 298
LEU A 164
 None
 1.13A 3dzyA-3k11A:
undetectable		 3dzyA-3k11A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Ehrlichia
chaffeensis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 ILE A  94
LEU A  13
ALA A  12
VAL A  63
LEU A 271
 None
 1.05A 3dzyA-3l0gA:
undetectable		 3dzyA-3l0gA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnt 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Burkholderia
pseudomallei) 		PF00300
(His_Phos_1) 		5 ILE A 179
ALA A 181
ARG A 158
LEU A  85
VAL A 171
 None
 1.08A 3dzyA-3lntA:
undetectable		 3dzyA-3lntA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5f N-CARBAMOYL-L-AMINO
ACID HYDROLASE

(Geobacillus
stearothermophilus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ALA A  97
ASN A 106
LEU A 398
ALA A 395
LEU A  50
 None
 1.00A 3dzyA-3n5fA:
undetectable		 3dzyA-3n5fA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2m POSSIBLE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		5 ILE A 161
ALA A 165
LEU A 268
ALA A 267
VAL A 179
 None
 1.06A 3dzyA-3p2mA:
undetectable		 3dzyA-3p2mA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE

(Pseudomonas
aeruginosa) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M)
PF14790
(THDPS_N) 		5 ILE A  37
ALA A  40
LEU A  68
ALA A  67
LEU A   5
 None
 1.12A 3dzyA-3r5bA:
undetectable		 3dzyA-3r5bA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 ILE N 250
ALA N 249
LEU N 119
ALA N 120
LEU N 306
 None
 1.00A 3dzyA-3rkoN:
undetectable		 3dzyA-3rkoN:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 ALA A 602
LEU A 622
ALA A 618
VAL A 636
LEU A 655
 None
 1.07A 3dzyA-3ttfA:
undetectable		 3dzyA-3ttfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 3

(Mus musculus) 		PF07528
(DZF) 		5 ILE B 314
ALA B 318
GLN B 319
LEU B 279
ALA B 280
 None
 1.14A 3dzyA-4atbB:
undetectable		 3dzyA-4atbB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo9 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Mycobacterium
leprae) 		PF00300
(His_Phos_1) 		5 ILE A 182
ALA A 184
PHE A 162
ARG A 161
LEU A  90
 None
 1.07A 3dzyA-4eo9A:
undetectable		 3dzyA-4eo9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		5 ALA A 541
ASN A 545
PHE A 530
LEU A 533
ALA A 529
 None
NAG  A 709 (-1.9A)
None
None
None
 1.08A 3dzyA-4fimA:
undetectable		 3dzyA-4fimA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 ILE A  25
ALA A 119
PHE A 264
ALA A 266
CYH A 183
 None
 1.08A 3dzyA-4im7A:
undetectable		 3dzyA-4im7A:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 8 GLN D 275
ASN D 306
SER D 312
ARG D 316
ALA D 327
VAL D 342
CYH D 432
LEU D 436
 None
 0.91A 3dzyA-4j5xD:
30.1		 3dzyA-4j5xD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 11 ILE D 268
ALA D 271
GLN D 275
ASN D 306
PHE D 313
ARG D 316
LEU D 326
ALA D 327
VAL D 342
CYH D 432
LEU D 436
 None
 0.71A 3dzyA-4j5xD:
30.1		 3dzyA-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 503
GLN A 660
LEU A 631
VAL A 493
LEU A 667
 None
 0.96A 3dzyA-4ks8A:
undetectable		 3dzyA-4ks8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		6 ILE A 292
SER A 235
ARG A 339
LEU A 309
ALA A 310
LEU A 257
 None
None
FAD  A2001 (-4.0A)
None
FAD  A2001 (-3.5A)
None
 1.40A 3dzyA-4q73A:
undetectable		 3dzyA-4q73A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qam X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR-INTERACTIN
G PROTEIN 1

(Homo sapiens) 		no annotation 5 ALA B1269
SER B1239
LEU B1273
ALA B1270
LEU B1248
 None
 1.13A 3dzyA-4qamB:
undetectable		 3dzyA-4qamB:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A1004
ALA A1050
LEU A1056
ALA A1051
LEU A1009
 None
 1.03A 3dzyA-4rcnA:
undetectable		 3dzyA-4rcnA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhm ARGINASE

(Trypanosoma
brucei) 		PF00491
(Arginase) 		5 ILE A  60
GLN A  47
SER A 289
PHE A  45
LEU A  46
 None
 1.07A 3dzyA-4rhmA:
undetectable		 3dzyA-4rhmA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		5 ILE A 264
GLN A 258
LEU A 134
ALA A 133
LEU A 286
 None
 1.00A 3dzyA-4v1uA:
undetectable		 3dzyA-4v1uA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		5 ALA A  53
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 0.90A 3dzyA-4xboA:
undetectable		 3dzyA-4xboA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypl LON PROTEASE

(Meiothermus
taiwanensis) 		PF00004
(AAA)
PF05362
(Lon_C) 		5 ILE A 687
PHE A 657
LEU A 663
ALA A 616
LEU A 766
 None
 1.12A 3dzyA-4yplA:
undetectable		 3dzyA-4yplA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG

(Bacillus
subtilis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 ALA A 248
PHE A 303
LEU A 306
ALA A 305
VAL A 125
 None
 1.11A 3dzyA-4yxtA:
undetectable		 3dzyA-4yxtA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix) 		5 ILE C  33
SER C  50
LEU C  31
ALA C  30
CYH C  38
 None
 1.06A 3dzyA-5a53C:
undetectable		 3dzyA-5a53C:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 ILE A 574
ASN A 612
SER A 636
LEU A 643
ALA A 642
 None
 1.09A 3dzyA-5aorA:
undetectable		 3dzyA-5aorA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4

(Mus musculus) 		PF01852
(START) 		5 ILE A 189
ALA A  71
PHE A 213
LEU A 210
LEU A  34
 None
 1.13A 3dzyA-5brlA:
undetectable		 3dzyA-5brlA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 ILE A 117
PHE A 619
LEU A 622
ALA A 621
VAL A 532
 None
 1.12A 3dzyA-5chcA:
undetectable		 3dzyA-5chcA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))

(Clostridioides
difficile) 		PF08501
(Shikimate_dh_N) 		5 ILE A 123
ALA A 121
SER A 140
LEU A 145
LEU A 209
 None
 1.04A 3dzyA-5dzsA:
undetectable		 3dzyA-5dzsA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		6 ILE A 394
SER A 402
PHE A 367
LEU A 363
ALA A 364
VAL A 385
 None
 1.39A 3dzyA-5frsA:
undetectable		 3dzyA-5frsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvd NUCLEOCAPSID

(Human
metapneumovirus) 		PF03246
(Pneumo_ncap) 		5 ILE A  67
ALA A  63
PHE A 214
LEU A 213
VAL A  79
 None
 1.01A 3dzyA-5fvdA:
undetectable		 3dzyA-5fvdA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7w THYMIDYLATE SYNTHASE

(Enterococcus
faecalis) 		PF00303
(Thymidylat_synt) 		5 ILE A 239
ALA A 240
LEU A 210
VAL A 181
LEU A  64
 None
 1.12A 3dzyA-5j7wA:
undetectable		 3dzyA-5j7wA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo7 VETISPIRADIENE
SYNTHASE 1

(Hyoscyamus
muticus) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ILE A 439
ALA A 442
ASN A 518
ALA A 494
VAL A 508
 None
 1.11A 3dzyA-5jo7A:
undetectable		 3dzyA-5jo7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l51 (-)-MENTHONE:(+)-NEO
MENTHOL REDUCTASE

(Mentha x
piperita) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		5 ILE A  29
ASN A  22
LEU A  33
ALA A  34
VAL A 186
 None
 0.98A 3dzyA-5l51A:
undetectable		 3dzyA-5l51A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 354
ALA A 355
LEU A 363
ALA A 360
LEU A 322
 None
 1.09A 3dzyA-5lnqA:
undetectable		 3dzyA-5lnqA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzb PROFILIN-2

(Betula pendula) 		no annotation 5 ILE A  27
ALA A 102
GLN A 101
LEU A 128
VAL A   7
 None
 1.03A 3dzyA-5nzbA:
undetectable		 3dzyA-5nzbA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 5 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.99A 3dzyA-5ohsA:
undetectable		 3dzyA-5ohsA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 12 ILE A 268
ALA A 271
GLN A 275
ASN A 306
SER A 312
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
None
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.84A 3dzyA-5uanA:
31.8		 3dzyA-5uanA:
78.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyt ICE-BINDING PROTEIN

(Flavobacteriaceae
bacterium
3519-10) 		no annotation 5 ALA A  30
LEU A  85
ALA A  81
VAL A 175
LEU A 202
 None
 1.04A 3dzyA-5uytA:
undetectable		 3dzyA-5uytA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgm DIHYDROOROTASE

(Vibrio cholerae) 		PF01979
(Amidohydro_1) 		5 ILE A  59
ALA A  62
ASN A  33
LEU A  22
ALA A  23
 None
 0.99A 3dzyA-5vgmA:
undetectable		 3dzyA-5vgmA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ILE B 247
ALA B 229
LEU B 378
VAL B 277
LEU B 354
 None
 1.13A 3dzyA-5xogB:
undetectable		 3dzyA-5xogB:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Homo sapiens) 		no annotation 5 ILE i  98
ALA i 101
LEU i  70
ALA i  66
LEU i 149
 None
 1.13A 3dzyA-5xtci:
undetectable		 3dzyA-5xtci:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 ALA C 672
GLN C 669
LEU C 712
ALA C 711
CYH C 652
 None
 1.02A 3dzyA-5zyaC:
undetectable		 3dzyA-5zyaC:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 ALA C 672
GLN C 669
LEU C 712
ALA C 711
LEU C 644
 None
 1.05A 3dzyA-5zyaC:
undetectable		 3dzyA-5zyaC:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 ALA C 672
GLN C 669
LEU C 712
ALA C 711
LEU C 644
 None
 1.03A 3dzyA-6en4C:
undetectable		 3dzyA-6en4C:
10.33