SIMILAR PATTERNS OF AMINO ACIDS FOR 3DZU_A_9CRA7223_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chm CREATINE
AMIDINOHYDROLASE

(Pseudomonas
putida) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ILE A  44
GLN A 112
LEU A 115
VAL A 148
LEU A 128
 None
 0.95A 3dzuA-1chmA:
undetectable		 3dzuA-1chmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		5 ILE A  37
ALA A  34
LEU A  97
VAL A   5
LEU A 234
 None
 1.05A 3dzuA-1e19A:
undetectable		 3dzuA-1e19A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1emy MYOGLOBIN

(Elephas maximus) 		PF00042
(Globin) 		5 ILE A 107
ALA A 110
PHE A  29
LEU A  32
LEU A  72
 HEM  A 154 ( 3.9A)
None
CYN  A 155 ( 4.9A)
None
HEM  A 154 ( 4.3A)
 1.01A 3dzuA-1emyA:
undetectable		 3dzuA-1emyA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fb5 ORNITHINE
TRANSCARBAMOYLASE

(Ovis aries) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A 137
ILE A 170
LEU A  82
VAL A 142
LEU A  43
 None
 1.10A 3dzuA-1fb5A:
undetectable		 3dzuA-1fb5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		5 ILE A 323
LEU A 366
VAL A 382
HIS A 475
LEU A 476
 None
LPP  A   1 ( 4.4A)
LPP  A   1 (-4.8A)
None
LPP  A   1 (-4.2A)
 0.79A 3dzuA-1hg4A:
24.4		 3dzuA-1hg4A:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		5 ILE A 323
VAL A 382
CYH A 472
HIS A 475
LEU A 476
 None
LPP  A   1 (-4.8A)
LPP  A   1 ( 4.2A)
None
LPP  A   1 (-4.2A)
 0.51A 3dzuA-1hg4A:
24.4		 3dzuA-1hg4A:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ion PROBABLE CELL
DIVISION INHIBITOR
MIND

(Pyrococcus
horikoshii) 		PF13614
(AAA_31) 		5 ILE A 169
ALA A 195
ILE A 203
PHE A 226
LEU A 229
 None
None
ADP  A 301 (-3.5A)
None
None
 0.99A 3dzuA-1ionA:
undetectable		 3dzuA-1ionA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kk0 EIF2GAMMA

(Pyrococcus
abyssi) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		5 ILE A 179
ALA A 181
ASN A 158
ILE A 114
LEU A  26
 None
 1.13A 3dzuA-1kk0A:
undetectable		 3dzuA-1kk0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxz HYPOTHETICAL PROTEIN
HI0303

(Haemophilus
influenzae) 		PF04452
(Methyltrans_RNA) 		5 ILE A 185
ASN A 105
ILE A  80
LEU A 167
HIS A  77
 None
 1.11A 3dzuA-1nxzA:
undetectable		 3dzuA-1nxzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 ARG A 297
LEU A 325
VAL A 341
HIS A 434
LEU A 435
 None
None
EPH  A4000 (-4.9A)
None
EPH  A4000 ( 4.6A)
 0.91A 3dzuA-1r20A:
24.2		 3dzuA-1r20A:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 ASN A 287
LEU A 325
VAL A 341
HIS A 434
LEU A 435
 None
None
EPH  A4000 (-4.9A)
None
EPH  A4000 ( 4.6A)
 0.89A 3dzuA-1r20A:
24.2		 3dzuA-1r20A:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Mycobacterium
tuberculosis) 		PF00300
(His_Phos_1) 		5 ILE A 180
ALA A 182
PHE A 160
ARG A 159
LEU A  88
 None
 1.02A 3dzuA-1riiA:
undetectable		 3dzuA-1riiA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1scj SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 ILE A 234
ALA A 274
GLN A 271
ILE A 268
VAL A 148
 None
 1.10A 3dzuA-1scjA:
undetectable		 3dzuA-1scjA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srv PROTEIN (GROEL
(HSP60 CLASS))

(Thermus
thermophilus) 		PF00118
(Cpn60_TCP1) 		5 ILE A 249
ASN A 265
PHE A 204
VAL A 227
LEU A 237
 None
 0.92A 3dzuA-1srvA:
undetectable		 3dzuA-1srvA:
15.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 339
ALA A 342
GLN A 346
ASN A 377
ILE A 381
PHE A 384
ARG A 387
LEU A 397
VAL A 413
CYH A 503
HIS A 506
LEU A 507
 MEI  A1001 (-3.8A)
MEI  A1001 (-3.1A)
None
None
MEI  A1001 ( 4.9A)
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-4.1A)
MEI  A1001 (-4.0A)
None
MEI  A1001 (-4.6A)
 0.72A 3dzuA-1uhlA:
33.2		 3dzuA-1uhlA:
66.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		5 ILE A 201
ALA A  84
VAL A 190
CYH A 225
LEU A 227
 None
 1.12A 3dzuA-1vhkA:
undetectable		 3dzuA-1vhkA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 ILE A 127
ALA A  55
LEU A 128
VAL A 260
LEU A 116
 None
None
None
EDO  A 502 (-4.3A)
None
 1.06A 3dzuA-1x3lA:
undetectable		 3dzuA-1x3lA:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		10 ALA A 245
GLN A 249
ASN A 280
ILE A 284
PHE A 287
ARG A 290
LEU A 300
VAL A 316
HIS A 409
LEU A 410
 9CR  A 201 (-3.6A)
9CR  A 201 (-4.1A)
None
None
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-4.2A)
9CR  A 201 (-4.8A)
9CR  A 201 ( 4.8A)
 0.69A 3dzuA-1xiuA:
30.3		 3dzuA-1xiuA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		11 ILE A 242
ALA A 245
GLN A 249
ILE A 284
PHE A 287
ARG A 290
LEU A 300
VAL A 316
CYH A 406
HIS A 409
LEU A 410
 9CR  A 201 ( 4.4A)
9CR  A 201 (-3.6A)
9CR  A 201 (-4.1A)
None
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-4.2A)
9CR  A 201 (-3.6A)
9CR  A 201 (-4.8A)
9CR  A 201 ( 4.8A)
 0.53A 3dzuA-1xiuA:
30.3		 3dzuA-1xiuA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ALA A 271
GLN A 275
ASN A 306
ILE A 310
PHE A 313
ARG A 316
LEU A 326
VAL A 342
CYH A 432
HIS A 435
LEU A 436
 9CR  A 801 (-3.6A)
9CR  A 801 (-4.7A)
None
None
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 ( 4.3A)
9CR  A 801 ( 3.7A)
None
9CR  A 801 (-4.7A)
 0.64A 3dzuA-1xlsA:
32.9		 3dzuA-1xlsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ILE A 268
ALA A 271
GLN A 275
ILE A 310
PHE A 313
ARG A 316
LEU A 326
VAL A 342
CYH A 432
HIS A 435
LEU A 436
 9CR  A 801 (-3.9A)
9CR  A 801 (-3.6A)
9CR  A 801 (-4.7A)
None
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 ( 4.3A)
9CR  A 801 ( 3.7A)
None
9CR  A 801 (-4.7A)
 0.51A 3dzuA-1xlsA:
32.9		 3dzuA-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE

(Salmonella
enterica) 		PF04223
(CitF) 		5 ILE A 501
GLN A 503
ASN A 383
ILE A 480
PHE A 482
 None
 1.07A 3dzuA-1xr4A:
undetectable		 3dzuA-1xr4A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a19 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		5 ILE A 129
ILE A 110
PHE A 144
LEU A 133
CYH A 114
 None
 0.96A 3dzuA-2a19A:
undetectable		 3dzuA-2a19A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx6 XRP2 PROTEIN

(Homo sapiens) 		PF07986
(TBCC) 		5 ILE A 254
GLN A 266
ILE A 166
PHE A 167
LEU A 300
 None
 0.90A 3dzuA-2bx6A:
undetectable		 3dzuA-2bx6A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5q RRAA-LIKE PROTEIN
YER010C

(Saccharomyces
cerevisiae) 		PF03737
(RraA-like) 		5 ILE A 159
GLN A  87
ILE A  92
VAL A  77
LEU A  34
 None
 1.12A 3dzuA-2c5qA:
undetectable		 3dzuA-2c5qA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2e SUFC PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran) 		5 ILE A  62
GLN A   3
LEU A  63
VAL A  57
LEU A  45
 None
 0.99A 3dzuA-2d2eA:
undetectable		 3dzuA-2d2eA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ALA A 440
ILE A 434
PHE A 447
LEU A 441
VAL A 401
 None
None
None
None
NAD  A1001 (-3.9A)
 1.07A 3dzuA-2d3tA:
undetectable		 3dzuA-2d3tA:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A  85
ILE A  89
PHE A  92
ARG A  95
VAL A 121
CYH A 211
 None
 0.54A 3dzuA-2gl8A:
26.7		 3dzuA-2gl8A:
48.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ILE A  89
PHE A  92
ARG A  95
LEU A 105
VAL A 121
CYH A 211
 None
 0.60A 3dzuA-2gl8A:
26.7		 3dzuA-2gl8A:
48.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpu NOSL PROTEIN

(Achromobacter
cycloclastes) 		PF05573
(NosL) 		5 ILE A  56
ALA A  36
GLN A  37
ILE A  68
VAL A 145
 None
 1.10A 3dzuA-2hpuA:
undetectable		 3dzuA-2hpuA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		5 ALA G 387
GLN G 363
ILE G 360
VAL G 429
LEU G 373
 None
 1.00A 3dzuA-2iouG:
undetectable		 3dzuA-2iouG:
21.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		6 ASN A 252
ILE A 256
PHE A 259
ARG A 262
LEU A 272
CYH A 378
 None
 1.07A 3dzuA-2nxxA:
24.3		 3dzuA-2nxxA:
33.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00342
(PGI) 		5 ILE A 255
ALA A 257
ILE A 337
LEU A 299
VAL A 184
 None
 1.07A 3dzuA-2o2cA:
undetectable		 3dzuA-2o2cA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00342
(PGI) 		5 ILE A 255
ALA A 257
LEU A 299
VAL A 184
LEU A 229
 None
 1.13A 3dzuA-2o2cA:
undetectable		 3dzuA-2o2cA:
20.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis) 		PF00104
(Hormone_recep) 		5 ASN A 181
ILE A 185
PHE A 188
ARG A 191
VAL A 217
 None
 0.90A 3dzuA-2q60A:
26.9		 3dzuA-2q60A:
43.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis) 		PF00104
(Hormone_recep) 		5 ILE A 185
PHE A 188
ARG A 191
VAL A 217
CYH A 307
 None
 0.61A 3dzuA-2q60A:
26.9		 3dzuA-2q60A:
43.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A  69
ALA A 103
GLN A 102
VAL A 387
LEU A  38
 None
 0.98A 3dzuA-2qdeA:
undetectable		 3dzuA-2qdeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		5 ILE A 725
ALA A 727
LEU A 648
VAL A 700
LEU A 620
 None
 0.96A 3dzuA-2qvwA:
undetectable		 3dzuA-2qvwA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am6 RHODOPSIN-2

(Acetabularia
acetabulum) 		PF01036
(Bac_rhodopsin) 		5 ILE A  44
ALA A  47
VAL A  95
CYH A 218
LEU A 219
 None
None
None
None
CLR  A 401 ( 4.6A)
 1.02A 3dzuA-3am6A:
undetectable		 3dzuA-3am6A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 ALA A 197
PHE A 179
LEU A 202
VAL A 112
LEU A 145
 None
 1.13A 3dzuA-3cinA:
undetectable		 3dzuA-3cinA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		5 ILE A 215
ALA A 247
ASN A 262
LEU A 248
VAL A 332
 None
 1.11A 3dzuA-3d0qA:
undetectable		 3dzuA-3d0qA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1

(Thermotoga
maritima) 		PF13507
(GATase_5) 		5 ILE D  72
ALA D  75
ILE D  46
LEU D  39
LEU D  92
 None
 1.00A 3dzuA-3d54D:
undetectable		 3dzuA-3d54D:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Kluyveromyces
lactis) 		PF01408
(GFO_IDH_MocA) 		5 ILE A 106
GLN A  83
ILE A  87
PHE A  81
VAL A 121
 None
 1.06A 3dzuA-3e1kA:
undetectable		 3dzuA-3e1kA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Kluyveromyces
lactis) 		PF01408
(GFO_IDH_MocA) 		5 ILE A 106
ILE A  87
PHE A  81
LEU A  78
VAL A 121
 None
 0.94A 3dzuA-3e1kA:
undetectable		 3dzuA-3e1kA:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eyb NUCLEAR HORMONE
RECEPTOR RXR

(Branchiostoma
floridae) 		PF00104
(Hormone_recep) 		5 ASN A 335
ILE A 339
PHE A 342
LEU A 355
VAL A 371
 None
 1.04A 3dzuA-3eybA:
27.2		 3dzuA-3eybA:
84.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eyb NUCLEAR HORMONE
RECEPTOR RXR

(Branchiostoma
floridae) 		PF00104
(Hormone_recep) 		6 ILE A 339
PHE A 342
LEU A 355
VAL A 371
CYH A 461
HIS A 464
 None
 0.99A 3dzuA-3eybA:
27.2		 3dzuA-3eybA:
84.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fov UPF0102 PROTEIN
RPA0323

(Rhodopseudomonas
palustris) 		PF02021
(UPF0102) 		5 ALA A 128
GLN A  84
ILE A  51
HIS A 101
LEU A  95
 None
 1.13A 3dzuA-3fovA:
undetectable		 3dzuA-3fovA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Lactobacillus
acidophilus) 		PF04909
(Amidohydro_2) 		5 ALA A 127
GLN A 128
ILE A 138
LEU A 103
LEU A 199
 None
 1.03A 3dzuA-3ij6A:
undetectable		 3dzuA-3ij6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2v PUTATIVE D-ARABINOSE
5-PHOSPHATE
ISOMERASE

(Klebsiella
pneumoniae) 		PF00571
(CBS) 		5 ILE A 238
ALA A 234
ILE A 258
CYH A 310
HIS A 324
 None
None
CMK  A   1 (-4.2A)
CMK  A   1 (-3.7A)
GOL  A 333 (-4.8A)
 1.14A 3dzuA-3k2vA:
undetectable		 3dzuA-3k2vA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9x GLUTATHIONE-REGULATE
D POTASSIUM-EFFLUX
SYSTEM PROTEIN KEFC,
LINKER, ANCILLARY
PROTEIN KEFF

(Escherichia
coli) 		PF02254
(TrkA_N)
PF02525
(Flavodoxin_2) 		6 ILE A1005
GLN A1050
ILE A1078
PHE A1082
LEU A1053
HIS A1063
 None
 1.38A 3dzuA-3l9xA:
undetectable		 3dzuA-3l9xA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnt 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Burkholderia
pseudomallei) 		PF00300
(His_Phos_1) 		5 ILE A 179
ALA A 181
ARG A 158
LEU A  85
VAL A 171
 None
 1.04A 3dzuA-3lntA:
undetectable		 3dzuA-3lntA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mda DNA POLYMERASE
LAMBDA

(Homo sapiens) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		5 ILE A 491
GLN A 400
ILE A 395
CYH A 477
LEU A 457
 None
 1.06A 3dzuA-3mdaA:
undetectable		 3dzuA-3mdaA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Archaeoglobus
fulgidus) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 ILE A 343
ALA A 346
ILE A 311
PHE A 373
VAL A 331
 None
 1.10A 3dzuA-3mm5A:
undetectable		 3dzuA-3mm5A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT

(Legionella
pneumophila) 		PF01596
(Methyltransf_3) 		5 ILE A 142
ALA A 144
LEU A  67
VAL A 217
LEU A 193
 None
 1.05A 3dzuA-3r3hA:
undetectable		 3dzuA-3r3hA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7a PHOSPHOGLYCERATE
MUTASE, PUTATIVE

(Bacillus
anthracis) 		PF00300
(His_Phos_1) 		5 ILE A 159
ILE A 183
LEU A 190
VAL A 174
LEU A  92
 None
 1.10A 3dzuA-3r7aA:
undetectable		 3dzuA-3r7aA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqn CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF05043
(Mga) 		5 ILE A 140
ARG A 215
LEU A 149
HIS A 125
LEU A 122
 None
 1.11A 3dzuA-3sqnA:
undetectable		 3dzuA-3sqnA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6c PUTATIVE MAND FAMILY
DEHYDRATASE

(Pantoea
ananatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  76
GLN A  73
ILE A  68
VAL A  24
LEU A  60
 None
EDO  A 706 ( 4.8A)
None
None
None
 1.06A 3dzuA-3t6cA:
undetectable		 3dzuA-3t6cA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 ILE A  96
ALA A  97
ASN A 193
ILE A  37
LEU A  44
 None
 1.12A 3dzuA-3wa1A:
undetectable		 3dzuA-3wa1A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 ILE A 324
ALA A 364
GLN A 361
ILE A 358
VAL A 238
 None
 1.10A 3dzuA-3whiA:
undetectable		 3dzuA-3whiA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0u UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		PF03945
(Endotoxin_N) 		5 ILE A 311
ILE A 406
LEU A 355
VAL A 388
LEU A 340
 None
 0.99A 3dzuA-3x0uA:
undetectable		 3dzuA-3x0uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zil AAR187CP

(Eremothecium
gossypii) 		PF16997
(Wap1) 		5 ILE A 471
ILE A 415
LEU A 424
VAL A 512
LEU A 438
 None
 1.12A 3dzuA-3zilA:
undetectable		 3dzuA-3zilA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 GLN A 340
ILE A 333
LEU A 341
CYH A 377
LEU A 392
 None
 1.13A 3dzuA-3zyvA:
undetectable		 3dzuA-3zyvA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akk NITRATE REGULATORY
PROTEIN

(Klebsiella
oxytoca) 		PF03861
(ANTAR)
PF08376
(NIT) 		6 ILE A 142
ALA A  36
GLN A  38
PHE A  82
LEU A  35
HIS A 138
 None
 1.50A 3dzuA-4akkA:
undetectable		 3dzuA-4akkA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 5 ILE A 830
GLN A 838
ILE A 811
PHE A 809
LEU A 836
 None
 1.12A 3dzuA-4ecoA:
undetectable		 3dzuA-4ecoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo9 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Mycobacterium
leprae) 		PF00300
(His_Phos_1) 		5 ILE A 182
ALA A 184
PHE A 162
ARG A 161
LEU A  90
 None
 1.02A 3dzuA-4eo9A:
undetectable		 3dzuA-4eo9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4er8 TNPAREP FOR PROTEIN

(Escherichia
coli) 		no annotation 5 ILE A  80
ILE A  50
PHE A  48
VAL A  18
LEU A  35
 None
 1.13A 3dzuA-4er8A:
undetectable		 3dzuA-4er8A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc3 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN H

(Staphylococcus
aureus) 		PF05031
(NEAT) 		5 ILE E 104
ALA E   6
ILE E 117
PHE E  79
LEU E  10
 None
 1.05A 3dzuA-4fc3E:
undetectable		 3dzuA-4fc3E:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 182
GLN A 430
ILE A 198
LEU A 433
VAL A  83
 None
 1.07A 3dzuA-4g1pA:
undetectable		 3dzuA-4g1pA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV

(Borreliella
burgdorferi) 		PF00496
(SBP_bac_5) 		5 GLN A 403
ILE A 400
LEU A 404
VAL A 494
LEU A 301
 None
 1.13A 3dzuA-4gl8A:
undetectable		 3dzuA-4gl8A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		5 ALA B 533
ILE B 440
VAL B 204
CYH B 504
LEU B 507
 None
 1.08A 3dzuA-4i0wB:
undetectable		 3dzuA-4i0wB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Dickeya
paradisiaca) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  76
GLN A  73
ILE A  68
VAL A  24
LEU A  60
 None
 1.08A 3dzuA-4ihcA:
undetectable		 3dzuA-4ihcA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij2 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN H

(Staphylococcus
aureus) 		PF05031
(NEAT) 		5 ILE E 424
ALA E 326
ILE E 437
PHE E 399
LEU E 330
 None
 1.02A 3dzuA-4ij2E:
undetectable		 3dzuA-4ij2E:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ija XYLR PROTEIN

(Staphylococcus
aureus) 		PF00480
(ROK)
PF01047
(MarR) 		5 ILE A 324
ALA A 327
GLN A 331
CYH A 315
LEU A 344
 None
 1.11A 3dzuA-4ijaA:
undetectable		 3dzuA-4ijaA:
23.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 12 ILE D 268
ALA D 271
GLN D 275
ASN D 306
ILE D 310
PHE D 313
ARG D 316
LEU D 326
VAL D 342
CYH D 432
HIS D 435
LEU D 436
 None
 0.68A 3dzuA-4j5xD:
31.7		 3dzuA-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A  58
ALA A  73
ILE A  81
LEU A  17
HIS A  95
 None
 1.04A 3dzuA-4ktoA:
undetectable		 3dzuA-4ktoA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnz PROBABLE ZINC
PROTEASE

(Pseudomonas
aeruginosa) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 ILE A 271
ALA A 406
GLN A 403
ILE A 349
LEU A 339
 None
 1.05A 3dzuA-4nnzA:
undetectable		 3dzuA-4nnzA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		5 ILE A 305
ALA A 313
ILE A 270
LEU A 309
LEU A 288
 None
 1.10A 3dzuA-4npaA:
undetectable		 3dzuA-4npaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens) 		no annotation 5 ILE C 256
ALA C 259
GLN C 261
ILE C 286
LEU C 260
 None
 1.05A 3dzuA-4rwtC:
undetectable		 3dzuA-4rwtC:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsd HP1029

(Helicobacter
pylori) 		no annotation 5 ILE B   3
ALA B 137
GLN B  88
PHE B  87
LEU B 136
 None
 1.11A 3dzuA-4tsdB:
undetectable		 3dzuA-4tsdB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		6 ILE A 421
ALA A 437
GLN A 439
ILE A 397
LEU A 390
LEU A 450
 None
 1.20A 3dzuA-4uvkA:
3.4		 3dzuA-4uvkA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE

(Colias
eurytheme) 		PF00342
(PGI) 		5 ILE A 210
ALA A 212
ILE A 287
LEU A 249
VAL A 140
 None
 1.12A 3dzuA-4wmjA:
undetectable		 3dzuA-4wmjA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxf ENVELOPE
GLYCOPROTEIN B

(Human
betaherpesvirus
5) 		PF00606
(Glycoprotein_B)
PF17416
(Glycoprot_B_PH1)
PF17417
(Glycoprot_B_PH2) 		5 ILE A 179
ILE A 305
PHE A 309
LEU A 213
VAL A 331
 None
 1.03A 3dzuA-5cxfA:
undetectable		 3dzuA-5cxfA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d95 AMINOTRANSFERASE
CLASS-III

(Sphaerobacter
thermophilus) 		PF00202
(Aminotran_3) 		5 ALA A 438
ILE A 413
PHE A 433
HIS A 377
LEU A 378
 None
 0.97A 3dzuA-5d95A:
undetectable		 3dzuA-5d95A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35

(Homo sapiens) 		PF03635
(Vps35) 		5 ILE A 303
ALA A 307
ILE A 267
VAL A 332
LEU A 279
 None
 1.13A 3dzuA-5f0kA:
undetectable		 3dzuA-5f0kA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 ILE B  96
ALA B  97
ASN B 193
ILE B  37
LEU B  44
 None
 1.10A 3dzuA-5fozB:
undetectable		 3dzuA-5fozB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsx PUTATIVE
ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF02668
(TauD) 		5 ILE A 129
ALA A 127
ILE A  42
PHE A  71
LEU A 285
 None
 0.78A 3dzuA-5hsxA:
undetectable		 3dzuA-5hsxA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5j DESMOCOLLIN-2,DESMOG
LEIN-2

(Homo sapiens) 		PF00028
(Cadherin) 		5 ILE A 130
ALA A 205
GLN A 206
ILE A 209
LEU A 162
 None
 1.06A 3dzuA-5j5jA:
undetectable		 3dzuA-5j5jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5keu TAURINE DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF02668
(TauD) 		5 ILE A 129
ALA A 127
ILE A  42
PHE A  71
LEU A 285
 None
 0.82A 3dzuA-5keuA:
undetectable		 3dzuA-5keuA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5j 30S RIBOSOMAL
PROTEIN S2

(Mycolicibacterium
smegmatis) 		PF00318
(Ribosomal_S2) 		5 ILE V 186
ALA V 210
GLN V  75
VAL V 196
CYH V 191
 None
 1.08A 3dzuA-5o5jV:
undetectable		 3dzuA-5o5jV:
19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 9 ALA A 271
GLN A 275
ASN A 306
ILE A 310
PHE A 313
ARG A 316
LEU A 326
VAL A 342
CYH A 432
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
9CR  A 503 ( 4.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
None
9CR  A 503 (-3.3A)
 0.84A 3dzuA-5uanA:
32.9		 3dzuA-5uanA:
78.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 11 ILE A 268
ALA A 271
GLN A 275
ILE A 310
PHE A 313
ARG A 316
LEU A 326
VAL A 342
CYH A 432
HIS A 435
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 ( 4.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
None
9CR  A 503 (-3.3A)
None
9CR  A 503 ( 4.8A)
 0.71A 3dzuA-5uanA:
32.9		 3dzuA-5uanA:
78.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vve PHOSPHOGLYCERATE
MUTASE

(Naegleria
fowleri) 		PF00300
(His_Phos_1) 		5 ILE A 180
ALA A 182
ARG A 159
LEU A  86
VAL A 172
 None
 1.04A 3dzuA-5vveA:
undetectable		 3dzuA-5vveA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
aureus) 		no annotation 5 ILE A 132
ALA A 150
ILE A 222
PHE A 218
LEU A 215
 None
 1.07A 3dzuA-5xexA:
undetectable		 3dzuA-5xexA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ILE B 247
ALA B 229
LEU B 378
VAL B 277
LEU B 354
 None
 1.09A 3dzuA-5xogB:
undetectable		 3dzuA-5xogB:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
epidermidis) 		no annotation 5 ILE A 132
ALA A 150
ILE A 222
PHE A 218
LEU A 215
 None
 1.07A 3dzuA-5yjjA:
undetectable		 3dzuA-5yjjA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arr ACETYL-COA
ACETYLTRANSFERASE

(Aspergillus
fumigatus) 		no annotation 5 ILE A  37
GLN A  31
ASN A  68
VAL A  52
CYH A  85
 None
 0.94A 3dzuA-6arrA:
undetectable		 3dzuA-6arrA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT D

(Saccharomyces
cerevisiae) 		no annotation 5 ILE B 221
ALA B 224
LEU B 256
HIS B 287
LEU B 284
 None
 1.11A 3dzuA-6c6lB:
undetectable		 3dzuA-6c6lB:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 5 ASN A 125
ILE A 110
LEU A 100
VAL A 157
LEU A 131
 None
 0.86A 3dzuA-6d6vA:
undetectable		 3dzuA-6d6vA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6de8 BIFUNCTIONAL PROTEIN
FOLD

(Campylobacter
jejuni) 		no annotation 5 ILE A 205
ALA A 160
ILE A 153
LEU A 177
VAL A 261
 None
 1.12A 3dzuA-6de8A:
undetectable		 3dzuA-6de8A:
11.24