SIMILAR PATTERNS OF AMINO ACIDS FOR 3DZG_B_NCAB302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avb ARCELIN-1

(Phaseolus
vulgaris)
PF00139
(Lectin_legB)
4 LEU A 105
ASP A 132
SER A 201
THR A 203
None
1.29A 3dzgB-1avbA:
undetectable
3dzgB-1avbA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnp DNA PHOTOLYASE

(Escherichia
coli)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
4 ASP A 113
TRP A   6
SER A  83
THR A  37
None
1.24A 3dzgB-1dnpA:
undetectable
3dzgB-1dnpA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ


(Phaseolus
vulgaris)
PF00139
(Lectin_legB)
4 LEU A 108
ASP A 141
SER A 208
THR A 210
None
1.38A 3dzgB-1g8wA:
undetectable
3dzgB-1g8wA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 LEU A 185
GLU A 288
TRP A 258
SER A 276
None
1.37A 3dzgB-1gycA:
undetectable
3dzgB-1gycA:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ism BONE MARROW STROMAL
CELL ANTIGEN 1


(Homo sapiens)
PF02267
(Rib_hydrolayse)
5 TRP A  77
LEU A  97
ASP A 107
TRP A 140
SER A 144
NCA  A 303 (-4.4A)
NCA  A 303 (-4.3A)
NCA  A 303 (-4.4A)
NCA  A 303 (-4.0A)
NCA  A 303 ( 3.7A)
0.49A 3dzgB-1ismA:
28.0
3dzgB-1ismA:
34.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7s FERRICHROME-BINDING
PERIPLASMIC PROTEIN


(Escherichia
coli)
PF01497
(Peripla_BP_2)
4 TRP N 273
LEU N  44
GLU N  42
TRP N 217
None
None
ALB  N 500 ( 3.9A)
ALB  N 500 (-3.7A)
1.31A 3dzgB-1k7sN:
undetectable
3dzgB-1k7sN:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE


(Methanosarcina
barkeri)
PF05369
(MtmB)
4 LEU A 295
GLU A 259
SER A 365
THR A 131
XPL  A 202 ( 4.8A)
XPL  A 202 (-2.7A)
XPL  A 202 ( 2.7A)
XPL  A 202 ( 4.5A)
1.33A 3dzgB-1l2qA:
undetectable
3dzgB-1l2qA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)


(Bifidobacterium
longum)
no annotation 4 LEU T 265
ASP T 267
SER T 263
THR T 280
None
1.33A 3dzgB-1lthT:
2.9
3dzgB-1lthT:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsv GALACTOSE MUTAROTASE

(Lactococcus
lactis)
PF01263
(Aldose_epim)
4 LEU A  14
ASP A  49
SER A  16
THR A  24
None
1.36A 3dzgB-1nsvA:
undetectable
3dzgB-1nsvA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qoz ACETYL XYLAN
ESTERASE


(Trichoderma
reesei)
PF01083
(Cutinase)
4 GLU A 108
ASP A 105
SER A  60
THR A  13
None
1.38A 3dzgB-1qozA:
2.1
3dzgB-1qozA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE


(Staphylococcus
aureus)
PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1)
4 LEU A 193
GLU A 197
SER A 186
THR A 400
None
1.38A 3dzgB-1qu2A:
undetectable
3dzgB-1qu2A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1se9 UBIQUITIN FAMILY

(Arabidopsis
thaliana)
PF13881
(Rad60-SLD_2)
4 LEU A  65
ASP A  73
SER A  60
THR A  86
None
1.30A 3dzgB-1se9A:
undetectable
3dzgB-1se9A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7h ORNITHINE
CYCLODEAMINASE


(Pseudomonas
putida)
PF02423
(OCD_Mu_crystall)
4 LEU A 235
GLU A 258
ASP A 292
THR A 202
None
None
None
NAD  A 802 (-4.1A)
1.14A 3dzgB-1u7hA:
undetectable
3dzgB-1u7hA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE


(Thermotoga
maritima)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
4 LEU A 308
GLU A  16
SER A 177
THR A 234
None
1.21A 3dzgB-1vknA:
undetectable
3dzgB-1vknA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT


(Corynebacterium
sp. U-96)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4)
4 LEU A 700
ASP A 698
SER A 720
THR A 722
None
None
SO4  A2002 ( 4.0A)
SO4  A2002 (-3.3A)
1.36A 3dzgB-1vrqA:
undetectable
3dzgB-1vrqA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wer P120GAP

(Homo sapiens)
PF00616
(RasGAP)
4 LEU A 787
GLU A 781
ASP A 782
THR A 792
None
1.18A 3dzgB-1werA:
undetectable
3dzgB-1werA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1


(Homo sapiens)
PF02263
(GBP)
PF02841
(GBP_C)
4 LEU A  67
GLU A 251
SER A  52
THR A  75
LEU  A  67 (-0.6A)
GLU  A 251 ( 0.6A)
SER  A  52 ( 0.0A)
THR  A  75 ( 0.8A)
1.32A 3dzgB-2b92A:
undetectable
3dzgB-2b92A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs0 HEMATOPOIETIC SH2
DOMAIN CONTAINING


(Homo sapiens)
PF00017
(SH2)
4 LEU A  41
ASP A  27
SER A  54
THR A  52
None
1.29A 3dzgB-2cs0A:
undetectable
3dzgB-2cs0A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE


(Thermus
thermophilus)
PF00171
(Aldedh)
4 LEU A 176
GLU A 110
SER A 179
THR A 170
None
1.31A 3dzgB-2d4eA:
undetectable
3dzgB-2d4eA:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eg9 ADP-RIBOSYL CYCLASE
1


(Mus musculus)
PF02267
(Rib_hydrolayse)
5 LEU A 149
GLU A 150
ASP A 159
TRP A 193
SER A 197
None
0.59A 3dzgB-2eg9A:
11.1
3dzgB-2eg9A:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eg9 ADP-RIBOSYL CYCLASE
1


(Mus musculus)
PF02267
(Rib_hydrolayse)
6 TRP A 129
LEU A 149
GLU A 150
TRP A 193
SER A 197
THR A 225
None
0.88A 3dzgB-2eg9A:
11.1
3dzgB-2eg9A:
54.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT


(Stenotrophomonas
maltophilia)
PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4)
4 LEU A 701
ASP A 699
SER A 721
THR A 723
None
1.39A 3dzgB-2gahA:
undetectable
3dzgB-2gahA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE


(Saccharomyces
cerevisiae)
PF00579
(tRNA-synt_1b)
4 GLU A 194
ASP A 238
SER A 291
THR A 249
None
1.36A 3dzgB-2ip1A:
undetectable
3dzgB-2ip1A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT


(Aromatoleum
aromaticum)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
4 LEU A 543
TRP A 200
SER A 214
THR A 207
None
1.32A 3dzgB-2ivfA:
2.7
3dzgB-2ivfA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN


(Bacteroides sp.
4_3_47FAA)
PF00578
(AhpC-TSA)
4 ASP A  71
TRP A  37
SER A  86
THR A  48
None
1.20A 3dzgB-2lrnA:
undetectable
3dzgB-2lrnA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE


(Lactobacillus
plantarum)
PF01643
(Acyl-ACP_TE)
4 LEU A 238
GLU A 240
ASP A 243
THR A 160
None
1.28A 3dzgB-2ownA:
undetectable
3dzgB-2ownA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7y RIBONUCLEASE H

(Bacillus
halodurans)
no annotation 4 ASP A 163
TRP A 159
SER A 147
THR A 104
None
1.39A 3dzgB-2r7yA:
undetectable
3dzgB-2r7yA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxy ALIPHATIC AMIDASE

(Pseudomonas
aeruginosa)
PF00795
(CN_hydrolase)
4 LEU A 119
ASP A 168
SER A 101
THR A 103
None
0.80A 3dzgB-2uxyA:
undetectable
3dzgB-2uxyA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhh CG3027-PA

(Drosophila
melanogaster)
PF00795
(CN_hydrolase)
4 LEU A 268
GLU A 272
SER A 265
THR A 260
None
1.12A 3dzgB-2vhhA:
undetectable
3dzgB-2vhhA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsi FAD SYNTHETASE

(Saccharomyces
cerevisiae)
PF01507
(PAPS_reduct)
4 LEU A 131
GLU A 133
ASP A 108
SER A 124
None
1.29A 3dzgB-2wsiA:
undetectable
3dzgB-2wsiA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2u UPF0026 PROTEIN
MJ0257


(Methanocaldococcus
jannaschii)
PF04055
(Radical_SAM)
PF08608
(Wyosine_form)
4 LEU A 268
GLU A 272
ASP A 271
SER A 251
None
1.32A 3dzgB-2z2uA:
undetectable
3dzgB-2z2uA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu MUS81 PROTEIN

(Danio rerio)
PF02732
(ERCC4)
4 LEU A 341
GLU A 329
ASP A 361
SER A 468
None
1.34A 3dzgB-2ziuA:
undetectable
3dzgB-2ziuA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdq STEROL CARRIER
PROTEIN 2-LIKE 2


(Aedes aegypti)
PF02036
(SCP2)
4 LEU A  67
GLU A  68
ASP A  69
SER A   2
None
1.28A 3dzgB-3bdqA:
undetectable
3dzgB-3bdqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgf F26G19 FAB
F26G19 FAB


(Mus musculus;
Mus musculus)
no annotation
no annotation
4 TRP L  96
LEU L  89
TRP H 103
SER L  34
None
1.10A 3dzgB-3bgfL:
undetectable
3dzgB-3bgfL:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqh L-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE ULAE


(Escherichia
coli)
PF01261
(AP_endonuc_2)
4 LEU A 189
GLU A 155
ASP A 120
THR A 215
None
1.18A 3dzgB-3cqhA:
2.2
3dzgB-3cqhA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis)
PF01274
(Malate_synthase)
4 LEU A 245
GLU A 247
ASP A 275
THR A  92
MG  A   1 ( 4.9A)
MG  A   1 (-2.6A)
MG  A   1 (-3.3A)
None
1.34A 3dzgB-3cuxA:
undetectable
3dzgB-3cuxA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv2 MALATE SYNTHASE A

(Escherichia
coli)
PF01274
(Malate_synthase)
4 LEU A 248
GLU A 250
ASP A 278
THR A  95
OXL  A1000 ( 4.7A)
MG  A   1 ( 2.6A)
MG  A   1 ( 3.1A)
None
1.26A 3dzgB-3cv2A:
2.5
3dzgB-3cv2A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN


(Methanosarcina
acetivorans)
PF00005
(ABC_tran)
PF03459
(TOBE)
4 LEU A 155
GLU A 190
ASP A 187
THR A 162
None
1.35A 3dzgB-3d31A:
undetectable
3dzgB-3d31A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dgt ENDO-1,3-BETA-GLUCAN
ASE


(Streptomyces
sioyaensis)
PF00722
(Glyco_hydro_16)
4 TRP A 137
GLU A 142
ASP A 144
THR A  47
None
1.34A 3dzgB-3dgtA:
undetectable
3dzgB-3dgtA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE


(Homo sapiens)
PF02898
(NO_synthase)
4 LEU A 125
ASP A 460
SER A 124
THR A 109
None
1.33A 3dzgB-3e7gA:
undetectable
3dzgB-3e7gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5a FMN
ADENYLYLTRANSFERASE


([Candida]
glabrata)
PF01507
(PAPS_reduct)
4 LEU A 132
GLU A 134
ASP A 109
SER A 125
None
1.25A 3dzgB-3g5aA:
undetectable
3dzgB-3g5aA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5a FMN
ADENYLYLTRANSFERASE


([Candida]
glabrata)
PF01507
(PAPS_reduct)
4 LEU A 132
GLU A 134
ASP A 109
THR A 124
None
1.17A 3dzgB-3g5aA:
undetectable
3dzgB-3g5aA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gc6 ECTO-NAD+
GLYCOHYDROLASE (CD38
MOLECULE)


(Bos taurus)
PF02267
(Rib_hydrolayse)
6 TRP A 118
LEU A 137
GLU A 138
ASP A 147
TRP A 181
SER A 185
None
0.55A 3dzgB-3gc6A:
30.5
3dzgB-3gc6A:
45.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhj MUTATOR MUTT PROTEIN

(Bartonella
henselae)
PF14815
(NUDIX_4)
4 LEU A  36
ASP A  38
TRP A 131
THR A  46
None
1.35A 3dzgB-3hhjA:
undetectable
3dzgB-3hhjA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht4 ALUMINUM RESISTANCE
PROTEIN


(Bacillus cereus)
PF06838
(Met_gamma_lyase)
4 LEU A  84
GLU A  71
ASP A  68
THR A 261
None
1.38A 3dzgB-3ht4A:
undetectable
3dzgB-3ht4A:
18.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i9k ADP-RIBOSYL CYCLASE

(Aplysia
californica)
PF02267
(Rib_hydrolayse)
5 TRP A  77
LEU A  97
GLU A  98
TRP A 140
SER A 144
None
0.40A 3dzgB-3i9kA:
25.1
3dzgB-3i9kA:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN


(Mycobacterium
tuberculosis)
PF01597
(GCV_H)
4 GLU A  80
ASP A 104
TRP A 101
SER A  83
None
1.24A 3dzgB-3iftA:
undetectable
3dzgB-3iftA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iln LAMINARINASE

(Rhodothermus
marinus)
PF00722
(Glyco_hydro_16)
4 TRP A 107
GLU A 134
ASP A 131
THR A 229
GOL  A 300 (-3.4A)
GOL  A 300 (-3.5A)
GOL  A 300 (-3.6A)
None
1.36A 3dzgB-3ilnA:
undetectable
3dzgB-3ilnA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR PRP5


(Schizosaccharomyces
pombe)
PF00400
(WD40)
4 GLU K 440
ASP K 442
SER K 427
THR K 377
None
1.32A 3dzgB-3jb9K:
undetectable
3dzgB-3jb9K:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7x LIN0763 PROTEIN

(Listeria
innocua)
PF03663
(Glyco_hydro_76)
4 TRP A 121
LEU A 124
ASP A 126
THR A 178
None
1.29A 3dzgB-3k7xA:
undetectable
3dzgB-3k7xA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE


(Streptomyces
coelicolor)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 GLU A 102
ASP A 115
SER A  96
THR A  41
None
0.99A 3dzgB-3krtA:
undetectable
3dzgB-3krtA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE


(Ehrlichia
chaffeensis)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
4 LEU A 211
ASP A 164
SER A 236
THR A 129
None
None
EDO  A 300 ( 4.6A)
EDO  A 300 (-4.2A)
1.39A 3dzgB-3l0gA:
2.2
3dzgB-3l0gA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE


(Chromohalobacter
salexigens)
PF13378
(MR_MLE_C)
4 LEU A 294
ASP A 290
TRP A 313
THR A 284
None
1.35A 3dzgB-3mznA:
undetectable
3dzgB-3mznA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq3 INTERFERON ALPHA-5
IFN-ALPHA/BETA
BINDING PROTEIN C12R


(Mus musculus;
Ectromelia
virus)
PF00143
(Interferon)
PF00047
(ig)
PF13895
(Ig_2)
4 LEU A  17
ASP B 259
SER A  84
THR A  80
None
1.06A 3dzgB-3oq3A:
undetectable
3dzgB-3oq3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2y ALANINE
DEHYDROGENASE/PYRIDI
NE NUCLEOTIDE
TRANSHYDROGENASE


(Mycolicibacterium
smegmatis)
PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N)
4 LEU A 308
GLU A 283
SER A 306
THR A 291
None
1.27A 3dzgB-3p2yA:
3.8
3dzgB-3p2yA:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p5s CD38 MOLECULE

(Bos taurus)
PF02267
(Rib_hydrolayse)
6 TRP A 118
LEU A 137
GLU A 138
ASP A 147
TRP A 181
SER A 185
AVU  A 280 (-3.8A)
AVU  A 280 (-3.7A)
AVU  A 280 (-3.3A)
AVU  A 280 (-3.9A)
AVU  A 280 (-3.6A)
AVU  A 280 (-2.9A)
0.50A 3dzgB-3p5sA:
30.4
3dzgB-3p5sA:
46.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q35 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75


(Saccharomyces
cerevisiae)
PF00956
(NAP)
4 LEU B  91
GLU B  94
SER B 104
THR B 122
None
1.20A 3dzgB-3q35B:
undetectable
3dzgB-3q35B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4


(Homo sapiens)
PF04130
(Spc97_Spc98)
4 LEU A 192
GLU A 304
ASP A 305
SER A 188
None
1.05A 3dzgB-3ripA:
undetectable
3dzgB-3ripA:
18.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rom ADP-RIBOSYL CYCLASE
1


(Homo sapiens)
PF02267
(Rib_hydrolayse)
7 TRP A 125
LEU A 145
GLU A 146
ASP A 155
TRP A 189
SER A 193
THR A 221
48Z  A 301 (-3.6A)
48Z  A 301 ( 4.8A)
48Z  A 301 ( 4.3A)
None
None
48Z  A 301 (-2.8A)
48Z  A 301 (-4.0A)
0.45A 3dzgB-3romA:
38.8
3dzgB-3romA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE


(Labrenzia
aggregata)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 365
ASP A 357
SER A 335
THR A 326
None
1.33A 3dzgB-3stpA:
undetectable
3dzgB-3stpA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1


(Bos taurus)
PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase)
4 LEU A 947
ASP A 962
SER A 901
THR A 905
None
0.98A 3dzgB-3tlmA:
undetectable
3dzgB-3tlmA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
4 GLU A 307
ASP A  14
SER A 273
THR A 250
None
1.18A 3dzgB-3ttsA:
undetectable
3dzgB-3ttsA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u58 TETRAHYMENA TEB1 AB

(Tetrahymena
thermophila)
PF01336
(tRNA_anti-codon)
4 LEU A 392
ASP A 411
TRP A 439
SER A 467
None
1.16A 3dzgB-3u58A:
undetectable
3dzgB-3u58A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz1 AGARASE

(Microbulbifer
thermotolerans)
PF00722
(Glyco_hydro_16)
4 TRP A 138
GLU A 257
SER A 109
THR A 111
None
1.22A 3dzgB-3wz1A:
undetectable
3dzgB-3wz1A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 LEU A 206
GLU A 309
TRP A 279
SER A 297
None
1.30A 3dzgB-3x1bA:
undetectable
3dzgB-3x1bA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 TRP A 587
LEU A 479
GLU A 613
THR A 484
None
1.31A 3dzgB-4c7vA:
undetectable
3dzgB-4c7vA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4u MANDALATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(unidentified)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 158
ASP A 355
TRP A 353
THR A 129
DTU  A 501 (-4.4A)
None
None
None
1.08A 3dzgB-4e4uA:
2.3
3dzgB-4e4uA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE


(Streptomyces
lydicus)
PF00501
(AMP-binding)
PF03621
(MbtH)
4 LEU A 416
ASP A 434
SER A 361
THR A 365
None
0.96A 3dzgB-4gr4A:
2.4
3dzgB-4gr4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr5 NON-RIBOSOMAL
PEPTIDE SYNTHETASE


(Streptomyces
lydicus)
PF00501
(AMP-binding)
PF03621
(MbtH)
4 LEU A 416
ASP A 434
SER A 361
THR A 365
TLA  A 602 (-4.6A)
None
None
None
0.98A 3dzgB-4gr5A:
2.4
3dzgB-4gr5A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn0 PUTATIVE 3-EPIMERASE
IN D-ALLOSE PATHWAY


(Streptomyces
bikiniensis)
PF00908
(dTDP_sugar_isom)
4 LEU A   4
GLU A  97
SER A  11
THR A 107
None
1.28A 3dzgB-4hn0A:
undetectable
3dzgB-4hn0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE


(Sus scrofa)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 LEU A 220
GLU A 201
ASP A 172
SER A 248
THR A 137
None
NCN  A 301 (-3.6A)
None
NCN  A 301 (-2.9A)
NCN  A 301 ( 4.4A)
1.50A 3dzgB-4i9aA:
2.2
3dzgB-4i9aA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP


(Aspergillus
fumigatus)
PF02128
(Peptidase_M36)
4 LEU A 449
TRP A 461
SER A 436
THR A 432
None
1.09A 3dzgB-4k90A:
undetectable
3dzgB-4k90A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1g PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE


(Bacillus cereus)
PF01522
(Polysacc_deac_1)
4 LEU A 232
ASP A  81
SER A 235
THR A 197
None
ACT  A 302 ( 4.0A)
None
None
1.11A 3dzgB-4l1gA:
undetectable
3dzgB-4l1gA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE


(Bacteroides
fragilis)
PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C)
4 LEU A 119
ASP A 117
SER A 271
THR A  50
None
1.35A 3dzgB-4ogzA:
2.1
3dzgB-4ogzA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
4 GLU A 320
ASP A  25
SER A 285
THR A 260
GOL  A 702 (-2.7A)
None
None
None
1.19A 3dzgB-4uzsA:
undetectable
3dzgB-4uzsA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxp NS3-4 PROTEASE

(Hepacivirus C)
PF07652
(Flavi_DEAD)
4 TRP A 582
LEU A 585
SER A 584
THR A 550
None
1.12A 3dzgB-4wxpA:
2.0
3dzgB-4wxpA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2q LECTIN

(Athelia rolfsii)
PF07367
(FB_lectin)
4 LEU A  82
GLU A  86
ASP A  85
SER A  62
None
1.25A 3dzgB-4z2qA:
undetectable
3dzgB-4z2qA:
22.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bni UNCHARACTERIZED
PROTEIN


(Sus scrofa)
PF02267
(Rib_hydrolayse)
6 LEU A 150
GLU A 151
ASP A 160
TRP A 193
SER A 197
THR A 225
None
0.83A 3dzgB-5bniA:
29.5
3dzgB-5bniA:
55.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhd CHITINASE

(Thermococcus
kodakarensis)
PF00553
(CBM_2)
4 GLU A 640
ASP A 642
TRP A 669
SER A 667
PE3  A 803 ( 4.6A)
PE3  A 803 (-3.4A)
None
None
1.24A 3dzgB-5dhdA:
undetectable
3dzgB-5dhdA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl6 PUTATIVE PORIN FOR
VANILLATE
TRAFFICKING (VANP)


(Acinetobacter
baumannii)
PF03573
(OprD)
4 LEU A 111
ASP A  56
SER A 134
THR A 136
None
1.09A 3dzgB-5dl6A:
undetectable
3dzgB-5dl6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlb CHAPERONE ESPG3

(Mycobacterium
marinum)
PF14011
(ESX-1_EspG)
4 TRP A  83
LEU A  84
TRP A 283
THR A 229
None
1.24A 3dzgB-5dlbA:
undetectable
3dzgB-5dlbA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus)
no annotation 4 LEU B 651
ASP B 653
SER B 675
THR B 672
None
1.28A 3dzgB-5dlqB:
undetectable
3dzgB-5dlqB:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dql ISOCITRATE LYASE 1

(Mycobacterium
tuberculosis)
PF00463
(ICL)
4 TRP A 283
ASP A 230
SER A 315
THR A 347
None
None
VGX  A 503 (-2.5A)
VGX  A 503 (-3.0A)
1.10A 3dzgB-5dqlA:
undetectable
3dzgB-5dqlA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dql ISOCITRATE LYASE 1

(Mycobacterium
tuberculosis)
PF00463
(ICL)
4 TRP A 283
GLU A 285
ASP A 230
SER A 315
None
None
None
VGX  A 503 (-2.5A)
1.40A 3dzgB-5dqlA:
undetectable
3dzgB-5dqlA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
4 GLU A 314
ASP A  19
SER A 274
THR A 251
ACT  A 702 (-3.3A)
None
None
None
1.24A 3dzgB-5e9aA:
2.4
3dzgB-5e9aA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9g ISOCITRATE LYASE

(Magnaporthe
oryzae)
PF00463
(ICL)
4 TRP A 403
ASP A 254
SER A 435
THR A 467
None
None
GOL  A 602 (-2.6A)
GOL  A 602 ( 3.0A)
1.15A 3dzgB-5e9gA:
undetectable
3dzgB-5e9gA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9h ISOCITRATE LYASE

(Fusarium
graminearum)
PF00463
(ICL)
4 TRP A 402
ASP A 254
SER A 434
THR A 466
None
None
MLI  A 602 (-2.8A)
MLI  A 602 (-2.9A)
1.08A 3dzgB-5e9hA:
2.4
3dzgB-5e9hA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN


(Homo sapiens)
PF00089
(Trypsin)
4 TRP A 141
LEU A  71
SER A  22
THR A 139
None
SO4  A 302 (-3.0A)
None
None
1.32A 3dzgB-5f8zA:
undetectable
3dzgB-5f8zA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2


(Homo sapiens)
no annotation 4 LEU I 667
GLU I 664
ASP I 400
SER I 697
None
1.27A 3dzgB-5furI:
undetectable
3dzgB-5furI:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT


(Escherichia
coli)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
4 LEU C 495
ASP C 464
SER C 472
THR C 470
None
None
MCN  C 921 (-4.2A)
MCN  C 921 (-3.8A)
1.38A 3dzgB-5g5gC:
undetectable
3dzgB-5g5gC:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE


(Pyrococcus
horikoshii)
PF02449
(Glyco_hydro_42)
4 LEU A 354
GLU A 105
TRP A 400
SER A 353
None
PO4  A 802 (-2.8A)
None
None
1.10A 3dzgB-5gslA:
2.2
3dzgB-5gslA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE


(Thermococcus
kodakarensis)
PF02449
(Glyco_hydro_42)
4 LEU A 352
GLU A 103
TRP A 398
SER A 351
GCS  A 801 (-4.9A)
GCS  A 801 (-2.9A)
None
None
1.11A 3dzgB-5gsmA:
2.2
3dzgB-5gsmA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0b MYELOID CELL SURFACE
ANTIGEN CD33


(Homo sapiens)
PF00047
(ig)
PF07686
(V-set)
4 LEU A 210
TRP A 179
SER A 181
THR A 185
None
1.29A 3dzgB-5j0bA:
undetectable
3dzgB-5j0bA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k66 NTA1P

(Saccharomyces
cerevisiae)
PF00795
(CN_hydrolase)
4 LEU A  66
ASP A  34
SER A  89
THR A  82
None
1.23A 3dzgB-5k66A:
undetectable
3dzgB-5k66A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6y PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE


(Bacillus cereus)
no annotation 4 LEU B 232
ASP B  81
SER B 235
THR B 197
None
5YA  B 302 ( 2.5A)
None
None
1.15A 3dzgB-5o6yB:
undetectable
3dzgB-5o6yB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ueb NEGOA.19184.A

(Neisseria
gonorrhoeae)
PF14085
(DUF4265)
4 LEU A  38
GLU A  19
SER A 104
THR A  71
None
0.94A 3dzgB-5uebA:
undetectable
3dzgB-5uebA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysq TM0415

(Thermotoga
maritima)
no annotation 4 LEU A 186
ASP A 173
SER A 189
THR A 181
None
SO4  A 302 (-3.6A)
None
None
1.28A 3dzgB-5ysqA:
3.0
3dzgB-5ysqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE


(Streptomyces
pristinaespiralis)
no annotation 4 LEU A 243
GLU A 266
ASP A 300
THR A 209
None
None
NA  A 401 (-3.6A)
NAD  A 402 (-4.0A)
1.07A 3dzgB-5yu1A:
2.4
3dzgB-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao3 GASDERMIN-D

(Mus musculus)
no annotation 4 LEU A 292
ASP A 288
TRP A 418
SER A 470
None
1.07A 3dzgB-6ao3A:
undetectable
3dzgB-6ao3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exn PRE-MRNA-SPLICING
FACTOR CLF1


(Saccharomyces
cerevisiae)
no annotation 4 LEU S  92
GLU S  89
SER S  96
THR S 128
None
1.25A 3dzgB-6exnS:
undetectable
3dzgB-6exnS:
undetectable