SIMILAR PATTERNS OF AMINO ACIDS FOR 3DZG_A_NCAA302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 LYS A 162
LEU A 276
GLU A 159
SER A 275
 None
 1.47A 3dzgA-1cqjA:
2.7		 3dzgA-1cqjA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 185
GLU A 288
TRP A 258
SER A 276
 None
 1.37A 3dzgA-1gycA:
undetectable		 3dzgA-1gycA:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ism BONE MARROW STROMAL
CELL ANTIGEN 1

(Homo sapiens) 		PF02267
(Rib_hydrolayse) 		5 TRP A  77
LEU A  97
ASP A 107
TRP A 140
SER A 144
 NCA  A 303 (-4.4A)
NCA  A 303 (-4.3A)
NCA  A 303 (-4.4A)
NCA  A 303 (-4.0A)
NCA  A 303 ( 3.7A)
 0.43A 3dzgA-1ismA:
14.9		 3dzgA-1ismA:
34.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7s FERRICHROME-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 TRP N 273
LEU N  44
GLU N  42
TRP N 217
 None
None
ALB  N 500 ( 3.9A)
ALB  N 500 (-3.7A)
 1.24A 3dzgA-1k7sN:
undetectable		 3dzgA-1k7sN:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 185
GLU A 288
TRP A 258
SER A 276
 None
 1.47A 3dzgA-1kyaA:
undetectable		 3dzgA-1kyaA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu5 CHLOROMUCONATE
CYCLOISOMERASE

(Pseudomonas sp.
P51) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LYS A 269
LEU A 248
ASP A 245
SER A 253
 MN  A 371 ( 4.2A)
None
MN  A 371 (-3.2A)
None
 1.46A 3dzgA-1nu5A:
2.6		 3dzgA-1nu5A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		4 LEU A 224
GLU A 220
ASP A 217
SER A 202
 None
 1.47A 3dzgA-1t8hA:
undetectable		 3dzgA-1t8hA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		4 LEU A 384
GLU A 387
ASP A 408
SER A 381
 None
 1.49A 3dzgA-1wd3A:
undetectable		 3dzgA-1wd3A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		4 LYS A 149
LEU A 134
GLU A  85
ASP A  84
 None
 1.30A 3dzgA-1wr8A:
undetectable		 3dzgA-1wr8A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chr CHLOROMUCONATE
CYCLOISOMERASE

(Cupriavidus
necator) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LYS A 269
LEU A 248
ASP A 245
SER A 253
 CL  A 500 (-3.3A)
None
MN  A 400 ( 3.1A)
None
 1.42A 3dzgA-2chrA:
undetectable		 3dzgA-2chrA:
22.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eg9 ADP-RIBOSYL CYCLASE
1

(Mus musculus) 		PF02267
(Rib_hydrolayse) 		5 LEU A 149
GLU A 150
ASP A 159
TRP A 193
SER A 197
 None
 0.56A 3dzgA-2eg9A:
11.6		 3dzgA-2eg9A:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eg9 ADP-RIBOSYL CYCLASE
1

(Mus musculus) 		PF02267
(Rib_hydrolayse) 		5 TRP A 129
LEU A 149
GLU A 150
TRP A 193
SER A 197
 None
 0.68A 3dzgA-2eg9A:
11.6		 3dzgA-2eg9A:
54.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3x TRANSCRIPTION FACTOR
FAPR

(Bacillus
subtilis) 		PF03061
(4HBT) 		4 LEU A  69
GLU A  73
ASP A  72
SER A  68
 None
 1.46A 3dzgA-2f3xA:
undetectable		 3dzgA-2f3xA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70

(Saccharomyces
cerevisiae) 		PF03081
(Exo70) 		4 LYS A 268
LEU A 260
ASP A 258
SER A 183
 None
 1.18A 3dzgA-2pfvA:
undetectable		 3dzgA-2pfvA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 185
GLU A 288
TRP A 258
SER A 276
 None
 1.46A 3dzgA-2qt6A:
undetectable		 3dzgA-2qt6A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsi FAD SYNTHETASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		4 LEU A 131
GLU A 133
ASP A 108
SER A 124
 None
 1.29A 3dzgA-2wsiA:
undetectable		 3dzgA-2wsiA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 185
GLU A 288
TRP A 258
SER A 276
 None
 1.44A 3dzgA-2xybA:
undetectable		 3dzgA-2xybA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2u UPF0026 PROTEIN
MJ0257

(Methanocaldococcus
jannaschii) 		PF04055
(Radical_SAM)
PF08608
(Wyosine_form) 		4 LEU A 268
GLU A 272
ASP A 271
SER A 251
 None
 1.29A 3dzgA-2z2uA:
undetectable		 3dzgA-2z2uA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu MUS81 PROTEIN

(Danio rerio) 		PF02732
(ERCC4) 		4 LEU A 341
GLU A 329
ASP A 361
SER A 468
 None
 1.34A 3dzgA-2ziuA:
2.2		 3dzgA-2ziuA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdq STEROL CARRIER
PROTEIN 2-LIKE 2

(Aedes aegypti) 		PF02036
(SCP2) 		4 LEU A  67
GLU A  68
ASP A  69
SER A   2
 None
 1.30A 3dzgA-3bdqA:
undetectable		 3dzgA-3bdqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgf F26G19 FAB
F26G19 FAB

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 TRP L  96
LEU L  89
TRP H 103
SER L  34
 None
 1.09A 3dzgA-3bgfL:
undetectable		 3dzgA-3bgfL:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 LYS A 319
GLU A 204
ASP A 203
SER A 291
 None
 1.41A 3dzgA-3ctzA:
undetectable		 3dzgA-3ctzA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efz 14-3-3 PROTEIN

(Cryptosporidium
parvum) 		PF00244
(14-3-3) 		4 LYS A 148
LEU A 132
ASP A 129
SER A 136
 EDO  A 305 ( 4.0A)
None
EDO  A 305 (-3.4A)
None
 1.45A 3dzgA-3efzA:
undetectable		 3dzgA-3efzA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N)
PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		4 LYS A1094
LEU A1110
ASP B 146
SER B  23
 None
 1.32A 3dzgA-3egwA:
undetectable		 3dzgA-3egwA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5a FMN
ADENYLYLTRANSFERASE

([Candida]
glabrata) 		PF01507
(PAPS_reduct) 		4 LEU A 132
GLU A 134
ASP A 109
SER A 125
 None
 1.28A 3dzgA-3g5aA:
undetectable		 3dzgA-3g5aA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gc6 ECTO-NAD+
GLYCOHYDROLASE (CD38
MOLECULE)

(Bos taurus) 		PF02267
(Rib_hydrolayse) 		7 TRP A 118
LYS A 122
LEU A 137
GLU A 138
ASP A 147
TRP A 181
SER A 185
 None
 0.80A 3dzgA-3gc6A:
30.2		 3dzgA-3gc6A:
45.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt7 SENSOR PROTEIN

(Syntrophus
aciditrophicus) 		PF00072
(Response_reg) 		4 LYS A 114
LEU A  90
ASP A  62
SER A 103
 None
 0.94A 3dzgA-3gt7A:
3.1		 3dzgA-3gt7A:
19.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i9k ADP-RIBOSYL CYCLASE

(Aplysia
californica) 		PF02267
(Rib_hydrolayse) 		5 TRP A  77
LEU A  97
GLU A  98
TRP A 140
SER A 144
 None
 0.45A 3dzgA-3i9kA:
25.3		 3dzgA-3i9kA:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Mycobacterium
tuberculosis) 		PF01597
(GCV_H) 		4 GLU A  80
ASP A 104
TRP A 101
SER A  83
 None
 1.25A 3dzgA-3iftA:
undetectable		 3dzgA-3iftA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH

(Streptomyces
glaucescens) 		PF13416
(SBP_bac_8) 		4 LYS A  67
LEU A  96
ASP A  89
SER A 293
 None
 1.37A 3dzgA-3jzjA:
undetectable		 3dzgA-3jzjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 LYS A 154
GLU A 156
ASP A 214
SER A 223
 None
 1.40A 3dzgA-3okyA:
undetectable		 3dzgA-3okyA:
16.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p5s CD38 MOLECULE

(Bos taurus) 		PF02267
(Rib_hydrolayse) 		6 TRP A 118
LEU A 137
GLU A 138
ASP A 147
TRP A 181
SER A 185
 AVU  A 280 (-3.8A)
AVU  A 280 (-3.7A)
AVU  A 280 (-3.3A)
AVU  A 280 (-3.9A)
AVU  A 280 (-3.6A)
AVU  A 280 (-2.9A)
 0.47A 3dzgA-3p5sA:
30.3		 3dzgA-3p5sA:
46.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p5s CD38 MOLECULE

(Bos taurus) 		PF02267
(Rib_hydrolayse) 		6 TRP A 118
LYS A 122
LEU A 137
ASP A 147
TRP A 181
SER A 185
 AVU  A 280 (-3.8A)
AVU  A 280 (-3.5A)
AVU  A 280 (-3.7A)
AVU  A 280 (-3.9A)
AVU  A 280 (-3.6A)
AVU  A 280 (-2.9A)
 0.81A 3dzgA-3p5sA:
30.3		 3dzgA-3p5sA:
46.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pja TRANSLIN

(Homo sapiens) 		PF01997
(Translin) 		4 LEU A 191
GLU A 138
ASP A 136
SER A 190
 None
 1.42A 3dzgA-3pjaA:
undetectable		 3dzgA-3pjaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 185
GLU A 288
TRP A 258
SER A 276
 None
 1.45A 3dzgA-3pxlA:
undetectable		 3dzgA-3pxlA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		4 LEU B  84
ASP B 407
TRP B  94
SER B  87
 None
 1.49A 3dzgA-3q75B:
undetectable		 3dzgA-3q75B:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4

(Homo sapiens) 		PF04130
(Spc97_Spc98) 		4 LEU A 192
GLU A 304
ASP A 305
SER A 188
 None
 1.01A 3dzgA-3ripA:
undetectable		 3dzgA-3ripA:
18.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rom ADP-RIBOSYL CYCLASE
1

(Homo sapiens) 		PF02267
(Rib_hydrolayse) 		7 TRP A 125
LYS A 129
LEU A 145
GLU A 146
ASP A 155
TRP A 189
SER A 193
 48Z  A 301 (-3.6A)
None
48Z  A 301 ( 4.8A)
48Z  A 301 ( 4.3A)
None
None
48Z  A 301 (-2.8A)
 0.60A 3dzgA-3romA:
38.6		 3dzgA-3romA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Lactobacillus
acidophilus) 		PF00215
(OMPdecase) 		4 LYS A 152
LEU A 178
ASP A 176
SER A 209
 None
 1.39A 3dzgA-3tfxA:
undetectable		 3dzgA-3tfxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1x PUTATIVE GLYCOSYL
HYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		4 TRP A 199
LYS A 204
LEU A 190
GLU A 197
 None
 0.93A 3dzgA-3u1xA:
undetectable		 3dzgA-3u1xA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4z TELOMERASE-ASSOCIATE
D PROTEIN 82

(Tetrahymena
thermophila) 		no annotation 4 LEU A 392
ASP A 411
TRP A 439
SER A 467
 None
 1.48A 3dzgA-3u4zA:
undetectable		 3dzgA-3u4zA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u58 TETRAHYMENA TEB1 AB

(Tetrahymena
thermophila) 		PF01336
(tRNA_anti-codon) 		4 LEU A 392
ASP A 411
TRP A 439
SER A 467
 None
 1.13A 3dzgA-3u58A:
undetectable		 3dzgA-3u58A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w53 BETA-GLUCOSIDASE

(Micrococcus
antarcticus) 		PF00232
(Glyco_hydro_1) 		4 LYS A 455
LEU A 426
ASP A 428
SER A  19
 None
 1.24A 3dzgA-3w53A:
1.4		 3dzgA-3w53A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 206
GLU A 309
TRP A 279
SER A 297
 None
 1.31A 3dzgA-3x1bA:
undetectable		 3dzgA-3x1bA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN

(Helicobacter
pylori) 		no annotation 4 LYS P  76
LEU P  69
GLU P  72
SER P  95
 None
 1.42A 3dzgA-4dvyP:
undetectable		 3dzgA-4dvyP:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sus scrofa) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 LEU A 220
GLU A 201
ASP A 172
SER A 248
 None
NCN  A 301 (-3.6A)
None
NCN  A 301 (-2.9A)
 1.41A 3dzgA-4i9aA:
undetectable		 3dzgA-4i9aA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii0 CRATABL

(Crateva tapia) 		PF00197
(Kunitz_legume) 		4 LEU A  24
ASP A  36
TRP A  78
SER A  75
 None
None
None
CSX  A  74 ( 4.3A)
 1.48A 3dzgA-4ii0A:
undetectable		 3dzgA-4ii0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 184
GLU A 287
TRP A 257
SER A 275
 None
 1.43A 3dzgA-4jhvA:
undetectable		 3dzgA-4jhvA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r94 NON-STRUCTURAL
PROTEIN NS1

(Rodent
protoparvovirus
1) 		PF12433
(PV_NSP1) 		4 LEU A  56
GLU A  53
TRP A 156
SER A  92
 None
 1.42A 3dzgA-4r94A:
undetectable		 3dzgA-4r94A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyz UNCHARACTERIZED
PROTEIN

(Leishmania
infantum) 		PF02893
(GRAM) 		4 GLU A 681
ASP A 680
TRP A 663
SER A 676
 None
 1.46A 3dzgA-4tyzA:
undetectable		 3dzgA-4tyzA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2q LECTIN

(Athelia rolfsii) 		PF07367
(FB_lectin) 		4 LEU A  82
GLU A  86
ASP A  85
SER A  62
 None
 1.20A 3dzgA-4z2qA:
undetectable		 3dzgA-4z2qA:
22.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bni UNCHARACTERIZED
PROTEIN

(Sus scrofa) 		PF02267
(Rib_hydrolayse) 		5 LEU A 150
GLU A 151
ASP A 160
TRP A 193
SER A 197
 None
 0.55A 3dzgA-5bniA:
29.3		 3dzgA-5bniA:
55.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhd CHITINASE

(Thermococcus
kodakarensis) 		PF00553
(CBM_2) 		4 GLU A 640
ASP A 642
TRP A 669
SER A 667
 PE3  A 803 ( 4.6A)
PE3  A 803 (-3.4A)
None
None
 1.24A 3dzgA-5dhdA:
undetectable		 3dzgA-5dhdA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dql ISOCITRATE LYASE 1

(Mycobacterium
tuberculosis) 		PF00463
(ICL) 		4 TRP A 283
GLU A 285
ASP A 230
SER A 315
 None
None
None
VGX  A 503 (-2.5A)
 1.48A 3dzgA-5dqlA:
undetectable		 3dzgA-5dqlA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 186
GLU A 290
TRP A 259
SER A 278
 None
 1.48A 3dzgA-5ehfA:
undetectable		 3dzgA-5ehfA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2

(Homo sapiens) 		no annotation 4 LEU I 667
GLU I 664
ASP I 400
SER I 697
 None
 1.28A 3dzgA-5furI:
undetectable		 3dzgA-5furI:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		4 LEU A 354
GLU A 105
TRP A 400
SER A 353
 None
PO4  A 802 (-2.8A)
None
None
 1.11A 3dzgA-5gslA:
undetectable		 3dzgA-5gslA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		4 LEU A 352
GLU A 103
TRP A 398
SER A 351
 GCS  A 801 (-4.9A)
GCS  A 801 (-2.9A)
None
None
 1.13A 3dzgA-5gsmA:
undetectable		 3dzgA-5gsmA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 LYS A 127
GLU A 124
ASP A 152
SER A 220
 None
 1.26A 3dzgA-5h07A:
undetectable		 3dzgA-5h07A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig8 ATP GRASP LIGASE

(Microcystis
aeruginosa) 		no annotation 4 LYS A  30
LEU A 323
ASP A 321
SER A  75
 None
 1.50A 3dzgA-5ig8A:
undetectable		 3dzgA-5ig8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Kribbella
flavida) 		PF13416
(SBP_bac_8) 		4 LEU A 233
GLU A 236
ASP A 235
SER A 227
 None
 1.40A 3dzgA-5ixpA:
undetectable		 3dzgA-5ixpA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtw COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 LYS B1030
LEU B1312
ASP B1310
SER B1286
 None
 1.09A 3dzgA-5jtwB:
undetectable		 3dzgA-5jtwB:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogz -

(-) 		no annotation 4 LYS A 433
LEU A 404
ASP A 406
SER A  14
 None
 1.24A 3dzgA-5ogzA:
1.3		 3dzgA-5ogzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao3 GASDERMIN-D

(Mus musculus) 		no annotation 4 LEU A 292
ASP A 288
TRP A 418
SER A 470
 None
 1.10A 3dzgA-6ao3A:
undetectable		 3dzgA-6ao3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Saccharomyces
cerevisiae) 		no annotation 4 LEU G 207
GLU G 144
ASP G 141
SER G 209
 None
 1.49A 3dzgA-6f42G:
undetectable		 3dzgA-6f42G:
undetectable