SIMILAR PATTERNS OF AMINO ACIDS FOR 3DTU_B_CUB1022_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ar1 CYTOCHROME C OXIDASE

(Paracoccus
denitrificans) 		PF00116
(COX2)
PF02790
(COX2_TM) 		3 CYH B 216
CYH B 220
HIS B 224
 CU  B 271 (-2.2A)
CU  B 270 (-2.1A)
CU  B 270 ( 3.2A)
 0.19A 3dtuB-1ar1B:
30.6		 3dtuB-1ar1B:
48.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyq INTRON-ENCODED
HOMING ENDONUCLEASE
I-PPOI

(Physarum
polycephalum) 		no annotation 3 CYH A  41
CYH A 100
HIS A 110
 ZN  A 602 (-2.3A)
ZN  A 602 (-2.3A)
ZN  A 602 (-3.2A)
 0.38A 3dtuB-1cyqA:
0.0		 3dtuB-1cyqA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyx CYOA

(Escherichia
coli) 		PF00116
(COX2)
PF06481
(COX_ARM) 		3 CYH A 207
CYH A 211
HIS A 215
 CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-2.8A)
 0.26A 3dtuB-1cyxA:
14.4		 3dtuB-1cyxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0q DNA PRIMASE

(Geobacillus
stearothermophilus) 		PF01807
(zf-CHC2) 		3 CYH A  64
CYH A  40
HIS A  43
 ZN  A 151 (-2.4A)
ZN  A 151 (-2.3A)
ZN  A 151 (-3.1A)
 0.89A 3dtuB-1d0qA:
0.0		 3dtuB-1d0qA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de6 L-RHAMNOSE ISOMERASE

(Escherichia
coli) 		PF06134
(RhaA) 		3 CYH A 143
CYH A 170
HIS A 169
 None
 0.67A 3dtuB-1de6A:
0.0		 3dtuB-1de6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp0 KAP-1 COREPRESSOR

(Homo sapiens) 		PF00628
(PHD) 		3 CYH A  28
CYH A  51
HIS A  48
 ZN  A  90 (-2.3A)
ZN  A  90 (-2.2A)
ZN  A  90 (-2.7A)
 0.62A 3dtuB-1fp0A:
undetectable		 3dtuB-1fp0A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		3 CYH A 561
CYH A 565
HIS A 569
 CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-3.0A)
 0.20A 3dtuB-1fwxA:
9.7		 3dtuB-1fwxA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE II

(Paracoccus
denitrificans) 		PF00116
(COX2)
PF02790
(COX2_TM) 		3 CYH B 216
CYH B 220
HIS B 224
 CUA  B 301 (-2.1A)
CUA  B 301 (-2.0A)
CUA  B 301 (-3.1A)
 0.26A 3dtuB-1qleB:
29.3		 3dtuB-1qleB:
56.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qni NITROUS-OXIDE
REDUCTASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 3 CYH A 561
CYH A 565
HIS A 569
 CUA  A 701 (-2.2A)
CUA  A 701 (-2.2A)
CUA  A 701 (-3.0A)
 0.23A 3dtuB-1qniA:
9.8		 3dtuB-1qniA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tbn PROTEIN KINASE C,
GAMMA TYPE

(Rattus rattus) 		PF00130
(C1_1) 		3 CYH A 143
CYH A 118
HIS A 117
 ZN  A   2 (-2.3A)
ZN  A   2 (-2.3A)
None
 0.88A 3dtuB-1tbnA:
undetectable		 3dtuB-1tbnA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		3 CYH A 499
CYH A 510
HIS A 512
 ZN  A2131 (-2.3A)
ZN  A2131 (-2.4A)
ZN  A2131 (-2.8A)
 0.67A 3dtuB-1urjA:
0.0		 3dtuB-1urjA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
DELTA SUBUNIT

(Corynebacterium
sp. U-96) 		PF04267
(SoxD) 		3 CYH D   6
CYH D  63
HIS D  59
 ZN  D1006 (-2.4A)
ZN  D1006 (-2.4A)
ZN  D1006 (-3.2A)
 0.54A 3dtuB-1vrqD:
undetectable		 3dtuB-1vrqD:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
DELTA SUBUNIT

(Corynebacterium
sp. U-96) 		PF04267
(SoxD) 		3 CYH D   9
CYH D  63
HIS D  59
 ZN  D1006 (-2.3A)
ZN  D1006 (-2.4A)
ZN  D1006 (-3.2A)
 0.68A 3dtuB-1vrqD:
undetectable		 3dtuB-1vrqD:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wir PROTEIN ARGININE
N-METHYLTRANSFERASE
3

(Mus musculus) 		no annotation 3 CYH A  18
CYH A  35
HIS A  34
 ZN  A 201 (-2.3A)
ZN  A 201 ( 4.3A)
ZN  A 201 (-3.4A)
 0.84A 3dtuB-1wirA:
undetectable		 3dtuB-1wirA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wo3 CREB BINDING PROTEIN

(Homo sapiens) 		no annotation 3 CYH A  23
CYH A  10
HIS A  19
 ZN  A  26 (-2.3A)
ZN  A  26 (-2.3A)
ZN  A  26 (-3.0A)
 0.85A 3dtuB-1wo3A:
undetectable		 3dtuB-1wo3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wo5 CREB BINDING PROTEIN

(Homo sapiens) 		no annotation 3 CYH A  23
CYH A  10
HIS A  19
 ZN  A  26 (-2.3A)
ZN  A  26 (-2.3A)
ZN  A  26 (-3.0A)
 0.68A 3dtuB-1wo5A:
undetectable		 3dtuB-1wo5A:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wo6 CREB BINDING PROTEIN

(Homo sapiens) 		no annotation 3 CYH A  23
CYH A  10
HIS A  19
 ZN  A  26 (-2.3A)
ZN  A  26 (-2.3A)
ZN  A  26 (-3.1A)
 0.88A 3dtuB-1wo6A:
undetectable		 3dtuB-1wo6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wo7 CREB BINDING PROTEIN

(Homo sapiens) 		no annotation 3 CYH A  23
CYH A  10
HIS A  19
 ZN  A  26 (-2.3A)
ZN  A  26 (-2.3A)
ZN  A  26 (-3.1A)
 0.73A 3dtuB-1wo7A:
undetectable		 3dtuB-1wo7A:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8f UNC-13 HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1) 		3 CYH A 600
CYH A 616
HIS A 567
 ZN  A 701 (-2.3A)
ZN  A 701 (-2.5A)
ZN  A 701 (-3.3A)
 0.75A 3dtuB-1y8fA:
undetectable		 3dtuB-1y8fA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY

(Vibrio cholerae) 		PF00480
(ROK) 		3 CYH A 257
CYH A 262
HIS A 245
 ZN  A 406 (-2.3A)
ZN  A 406 (-2.2A)
ZN  A 406 (-3.2A)
 0.69A 3dtuB-1z05A:
undetectable		 3dtuB-1z05A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		3 CYH A 259
CYH A 264
HIS A 247
 ZN  A 501 (-2.2A)
ZN  A 501 (-2.2A)
ZN  A 501 (-3.0A)
 0.73A 3dtuB-1z6rA:
undetectable		 3dtuB-1z6rA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		3 CYH A 168
CYH A 173
HIS A 156
 ZN  A1001 (-2.2A)
ZN  A1001 (-2.2A)
ZN  A1001 (-3.2A)
 0.72A 3dtuB-2aa4A:
undetectable		 3dtuB-2aa4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap1 PUTATIVE REGULATOR
PROTEIN

(Salmonella
enterica) 		PF00480
(ROK) 		3 CYH A 179
CYH A 184
HIS A 157
 ZN  A 304 (-2.3A)
ZN  A 304 (-2.3A)
ZN  A 304 (-3.2A)
 0.70A 3dtuB-2ap1A:
undetectable		 3dtuB-2ap1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5l NONSTRUCTURAL
PROTEIN V

(Mammalian
rubulavirus 5) 		PF13008
(zf-Paramyx-P)
PF14313
(Soyouz_module) 		3 CYH C 215
CYH C 190
HIS C 171
 ZN  C3002 (-2.2A)
ZN  C3002 (-2.2A)
ZN  C3002 (-4.0A)
 0.61A 3dtuB-2b5lC:
undetectable		 3dtuB-2b5lC:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be7 ASPARTATE
CARBAMOYLTRANSFERASE
REGULATORY CHAIN

(Moritella
profunda) 		PF01948
(PyrI)
PF02748
(PyrI_C) 		3 CYH D 108
CYH D 113
HIS D 116
 ZN  D1108 (-2.2A)
ZN  D1108 (-2.3A)
None
 0.84A 3dtuB-2be7D:
undetectable		 3dtuB-2be7D:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl6 NUCLEOCAPSID PROTEIN
P11

(Equine
infectious
anemia virus) 		PF00098
(zf-CCHC) 		3 CYH A  56
CYH A  46
HIS A  51
 ZN  A1060 (-2.1A)
ZN  A1060 (-2.1A)
ZN  A1060 (-3.3A)
 0.79A 3dtuB-2bl6A:
undetectable		 3dtuB-2bl6A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dj8 PROTEIN CBFA2T1

(Homo sapiens) 		PF01753
(zf-MYND) 		3 CYH A  29
CYH A  54
HIS A  50
 ZN  A 401 (-2.1A)
ZN  A 401 (-2.3A)
ZN  A 401 (-3.2A)
 0.76A 3dtuB-2dj8A:
undetectable		 3dtuB-2dj8A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e73 PROTEIN KINASE C
GAMMA TYPE

(Homo sapiens) 		PF00130
(C1_1) 		3 CYH A  77
CYH A  52
HIS A  51
 ZN  A 201 (-2.2A)
ZN  A 201 (-2.2A)
None
 0.86A 3dtuB-2e73A:
undetectable		 3dtuB-2e73A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpr HISTIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
HISB

(Escherichia
coli) 		PF08645
(PNK3P) 		3 CYH A  94
CYH A 102
HIS A  96
 ZN  A 502 (-2.3A)
ZN  A 502 (-2.3A)
ZN  A 502 (-3.2A)
 0.75A 3dtuB-2fprA:
undetectable		 3dtuB-2fprA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
DELTA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF04267
(SoxD) 		3 CYH D   6
CYH D  63
HIS D  59
 ZN  D 101 (-2.2A)
ZN  D 101 (-2.2A)
ZN  D 101 (-3.2A)
 0.50A 3dtuB-2gahD:
undetectable		 3dtuB-2gahD:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
DELTA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF04267
(SoxD) 		3 CYH D   9
CYH D  63
HIS D  59
 ZN  D 101 (-2.2A)
ZN  D 101 (-2.2A)
ZN  D 101 (-3.2A)
 0.77A 3dtuB-2gahD:
undetectable		 3dtuB-2gahD:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jz8 UNCHARACTERIZED
PROTEIN BH09830

(Bartonella
henselae) 		PF10276
(zf-CHCC) 		3 CYH A  54
CYH A  27
HIS A  38
 ZN  A 150 (-2.1A)
ZN  A 150 (-2.1A)
ZN  A 150 (-3.1A)
 0.87A 3dtuB-2jz8A:
undetectable		 3dtuB-2jz8A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyu HISTONE-LYSINE
N-METHYLTRANSFERASE
MLL

(Homo sapiens) 		PF00628
(PHD) 		3 CYH A  11
CYH A  38
HIS A  35
 ZN  A  81 (-2.3A)
ZN  A  81 (-2.4A)
ZN  A  81 (-3.1A)
 0.63A 3dtuB-2kyuA:
undetectable		 3dtuB-2kyuA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l0b E3 UBIQUITIN-PROTEIN
LIGASE PRAJA-1

(Homo sapiens) 		PF13639
(zf-RING_2) 		3 CYH A  43
CYH A  69
HIS A  66
 ZN  A 143 (-2.4A)
ZN  A 143 (-2.4A)
ZN  A 143 (-3.1A)
 0.76A 3dtuB-2l0bA:
undetectable		 3dtuB-2l0bA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lq6 BROMODOMAIN-CONTAINI
NG PROTEIN 1

(Homo sapiens) 		PF13771
(zf-HC5HC2H) 		3 CYH A 346
CYH A 385
HIS A 388
 ZN  A 402 (-2.1A)
ZN  A 402 (-2.1A)
ZN  A 402 (-3.3A)
 0.78A 3dtuB-2lq6A:
undetectable		 3dtuB-2lq6A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxw XIAP-ASSOCIATED
FACTOR 1

(Homo sapiens) 		no annotation 3 CYH A  24
CYH A  40
HIS A  36
 ZN  A 101 (-1.9A)
ZN  A 101 (-1.9A)
ZN  A 101 (-3.3A)
 0.88A 3dtuB-2lxwA:
undetectable		 3dtuB-2lxwA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lzu LIM
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00412
(LIM) 		3 CYH A  43
CYH A  67
HIS A  64
 ZN  A 201 (-2.2A)
ZN  A 201 (-2.2A)
ZN  A 201 (-3.0A)
 0.53A 3dtuB-2lzuA:
undetectable		 3dtuB-2lzuA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m1s RING FINGER PROTEIN
Z

(Lassa
mammarenavirus) 		PF03854
(zf-P11) 		3 CYH A  64
CYH A  44
HIS A  47
 ZN  A 101 (-2.3A)
ZN  A 101 (-2.3A)
ZN  A 101 (-3.1A)
 0.78A 3dtuB-2m1sA:
undetectable		 3dtuB-2m1sA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n94 BOX C/D SNORNA
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF04438
(zf-HIT) 		3 CYH A  39
CYH A  20
HIS A  33
 ZN  A 102 (-2.3A)
ZN  A 102 (-2.3A)
ZN  A 102 (-2.9A)
 0.88A 3dtuB-2n94A:
undetectable		 3dtuB-2n94A:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2naa HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Mus musculus) 		no annotation 3 CYH A   9
CYH A  34
HIS A  31
 ZN  A 101 (-2.3A)
ZN  A 101 (-2.3A)
ZN  A 101 (-3.0A)
 0.65A 3dtuB-2naaA:
undetectable		 3dtuB-2naaA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2naa HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Mus musculus) 		no annotation 3 CYH A  26
CYH A  47
HIS A  50
 ZN  A 102 (-2.2A)
ZN  A 102 (-2.3A)
ZN  A 102 (-2.8A)
 0.86A 3dtuB-2naaA:
undetectable		 3dtuB-2naaA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2od1 PROTEIN CBFA2T1

(Homo sapiens) 		PF01753
(zf-MYND) 		3 CYH A 674
CYH A 699
HIS A 695
 ZN  A 902 (-2.3A)
ZN  A 902 (-2.3A)
ZN  A 902 (-3.1A)
 0.85A 3dtuB-2od1A:
undetectable		 3dtuB-2od1A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odd PROTEIN CBFA2T1

(Homo sapiens) 		PF01753
(zf-MYND) 		3 CYH A 674
CYH A 699
HIS A 695
 ZN  A   2 (-2.3A)
ZN  A   2 (-2.3A)
ZN  A   2 (-3.2A)
 0.87A 3dtuB-2oddA:
undetectable		 3dtuB-2oddA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmn TUMOR PROTEIN 63

(Homo sapiens) 		PF00870
(P53) 		3 CYH A 205
CYH A 269
HIS A 208
 ZN  A   1 (-2.1A)
ZN  A   1 (-2.1A)
ZN  A   1 (-3.3A)
 0.85A 3dtuB-2rmnA:
undetectable		 3dtuB-2rmnA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmn TUMOR PROTEIN 63

(Homo sapiens) 		PF00870
(P53) 		3 CYH A 273
CYH A 269
HIS A 208
 ZN  A   1 (-2.2A)
ZN  A   1 (-2.1A)
ZN  A   1 (-3.3A)
 0.78A 3dtuB-2rmnA:
undetectable		 3dtuB-2rmnA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl6 MINICHROMOSOME
MAINTENANCE PROTEIN
MCM

(Sulfolobus
solfataricus) 		PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 CYH A 171
CYH A 149
HIS A 144
 ZN  A1266 (-2.0A)
ZN  A1266 (-2.2A)
ZN  A1266 (-3.1A)
 0.60A 3dtuB-2vl6A:
undetectable		 3dtuB-2vl6A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy5 U11/U12 SMALL
NUCLEAR
RIBONUCLEOPROTEIN 48
KDA PROTEIN

(Homo sapiens) 		PF05253
(zf-U11-48K) 		3 CYH A  78
CYH A  58
HIS A  64
 ZN  A1088 (-2.3A)
ZN  A1088 (-2.3A)
ZN  A1088 (-2.9A)
 0.85A 3dtuB-2vy5A:
undetectable		 3dtuB-2vy5A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy5 U11/U12 SMALL
NUCLEAR
RIBONUCLEOPROTEIN 48
KDA PROTEIN

(Homo sapiens) 		PF05253
(zf-U11-48K) 		3 CYH A  78
CYH A  58
HIS A  74
 ZN  A1088 (-2.3A)
ZN  A1088 (-2.3A)
ZN  A1088 (-2.9A)
 0.84A 3dtuB-2vy5A:
undetectable		 3dtuB-2vy5A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xoc E3 UBIQUITIN-PROTEIN
LIGASE CHFR

(Homo sapiens) 		no annotation 3 CYH A 524
CYH A 532
HIS A 519
 ZN  A 993 ( 2.4A)
ZN  A 993 (-2.4A)
None
 0.77A 3dtuB-2xocA:
undetectable		 3dtuB-2xocA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM) 		3 CYH B 197
CYH B 201
HIS B 205
 CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-3.1A)
 0.17A 3dtuB-2yevB:
17.1		 3dtuB-2yevB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yre F-BOX ONLY PROTEIN
30

(Homo sapiens) 		PF15965
(zf-TRAF_2) 		3 CYH A  10
CYH A  28
HIS A  42
 ZN  A 401 ( 2.2A)
ZN  A 401 ( 2.2A)
ZN  A 501 ( 3.2A)
 0.88A 3dtuB-2yreA:
undetectable		 3dtuB-2yreA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		3 CYH A 823
CYH A 897
HIS A 798
 ZN  A2004 (-2.2A)
ZN  A2004 (-2.2A)
None
 0.85A 3dtuB-3av6A:
undetectable		 3dtuB-3av6A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2n MUSCLEBLIND-LIKE
PROTEIN 1

(Homo sapiens) 		no annotation 3 CYH A  61
CYH A  66
HIS A  70
 ZN  A 102 (-2.3A)
ZN  A 102 (-2.3A)
ZN  A 102 (-3.3A)
 0.89A 3dtuB-3d2nA:
undetectable		 3dtuB-3d2nA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF00480
(ROK) 		3 CYH A 581
CYH A 586
HIS A 569
 ZN  A 801 (-2.3A)
ZN  A 801 (-2.2A)
ZN  A 801 (-3.1A)
 0.70A 3dtuB-3eo3A:
undetectable		 3dtuB-3eo3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esr D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE

(Escherichia
coli) 		PF13242
(Hydrolase_like) 		3 CYH A 112
CYH A 127
HIS A 114
 ZN  A 212 (-2.2A)
ZN  A 212 (-2.4A)
ZN  A 212 (-3.4A)
 0.72A 3dtuB-3esrA:
undetectable		 3dtuB-3esrA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdi UNCHARACTERIZED
PROTEIN

(Eubacterium
ventriosum) 		PF13189
(Cytidylate_kin2) 		3 CYH A 161
CYH A 104
HIS A 157
 None
 0.80A 3dtuB-3fdiA:
undetectable		 3dtuB-3fdiA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8e D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE

(Escherichia
coli) 		PF13242
(Hydrolase_like) 		3 CYH A  92
CYH A 107
HIS A  94
 ZN  A 801 (-2.2A)
ZN  A 801 (-2.3A)
ZN  A 801 (-3.2A)
 0.73A 3dtuB-3l8eA:
undetectable		 3dtuB-3l8eA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8h PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bordetella
bronchiseptica) 		PF13242
(Hydrolase_like) 		3 CYH A  89
CYH A  97
HIS A  91
 ZN  A 901 (-2.3A)
ZN  A 901 (-2.2A)
ZN  A 901 (-3.1A)
 0.85A 3dtuB-3l8hA:
undetectable		 3dtuB-3l8hA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 PROTEIN TAT

(Human
immunodeficiency
virus 1) 		PF00539
(Tat) 		3 CYH C  22
CYH C  34
HIS C  33
 ZN  C  87 (-2.3A)
ZN  C  87 (-2.3A)
ZN  C  87 (-3.3A)
 0.80A 3dtuB-3mi9C:
undetectable		 3dtuB-3mi9C:
15.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3om3 CYTOCHROME C OXIDASE
SUBUNIT 2

(Rhodobacter
sphaeroides) 		PF00116
(COX2)
PF02790
(COX2_TM) 		3 CYH B 252
CYH B 256
HIS B 260
 CU1  B 288 ( 2.2A)
CU1  B 287 ( 2.3A)
CU1  B 287 (-3.0A)
 0.09A 3dtuB-3om3B:
35.5		 3dtuB-3om3B:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		3 CYH A 820
CYH A 893
HIS A 795
 ZN  A   3 (-2.3A)
ZN  A   3 (-2.4A)
None
 0.88A 3dtuB-3ptaA:
undetectable		 3dtuB-3ptaA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s38 CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00116
(COX2)
PF09125
(COX2-transmemb) 		3 CYH B 149
CYH B 153
HIS B 157
 CUA  B 802 (-1.9A)
CUA  B 802 (-2.0A)
CUA  B 802 (-2.7A)
 0.38A 3dtuB-3s38B:
9.3		 3dtuB-3s38B:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 3 CYH A 618
CYH A 622
HIS A 626
 CUA  A 701 (-2.2A)
CUA  A 701 (-2.3A)
CUA  A 701 (-3.0A)
 0.25A 3dtuB-3sbqA:
8.0		 3dtuB-3sbqA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9g ZINC FINGER
CCCH-TYPE ANTIVIRAL
PROTEIN 1

(Rattus
norvegicus) 		no annotation 3 CYH A  96
CYH A 106
HIS A 110
 ZN  A 227 (-2.3A)
ZN  A 227 (-2.4A)
ZN  A 227 (-3.1A)
 0.88A 3dtuB-3u9gA:
undetectable		 3dtuB-3u9gA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgl GLUCOKINASE

(Streptomyces
griseus) 		PF00480
(ROK) 		3 CYH A 169
CYH A 174
HIS A 157
 ZN  A 322 (-2.2A)
ZN  A 322 (-2.2A)
ZN  A 322 ( 3.2A)
 0.69A 3dtuB-3vglA:
undetectable		 3dtuB-3vglA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vov GLUCOKINASE

(Thermus
thermophilus) 		PF00480
(ROK) 		3 CYH A 171
CYH A 176
HIS A 159
 ZN  A 401 (-2.3A)
ZN  A 401 (-2.3A)
ZN  A 401 (-3.1A)
 0.73A 3dtuB-3vovA:
undetectable		 3dtuB-3vovA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpb ALPHA-AMINOADIPATE
CARRIER PROTEIN LYSW

(Sulfurisphaera
tokodaii) 		no annotation 3 CYH E   6
CYH E  29
HIS E  27
 ZN  E 100 (-2.2A)
ZN  E 100 (-2.3A)
ZN  E 100 (-3.2A)
 0.54A 3dtuB-3vpbE:
undetectable		 3dtuB-3vpbE:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zj2 NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
NAB2

(Saccharomyces
cerevisiae) 		PF14608
(zf-CCCH_2) 		3 CYH A 351
CYH A 340
HIS A 355
 ZN  A 501 (-2.4A)
ZN  A 501 (-2.4A)
ZN  A 501 (-3.6A)
 0.88A 3dtuB-3zj2A:
undetectable		 3dtuB-3zj2A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a24 DEFORMED EPIDERMAL
AUTOREGULATORY
FACTOR 1 HOMOLOG

(Homo sapiens) 		PF01753
(zf-MYND) 		3 CYH A 515
CYH A 540
HIS A 536
 ZN  A 602 (-2.3A)
ZN  A 602 (-2.3A)
ZN  A 602 (-3.1A)
 0.84A 3dtuB-4a24A:
undetectable		 3dtuB-4a24A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Saccharomyces
cerevisiae) 		no annotation 3 CYH A  30
CYH A  14
HIS A  34
 ZN  A  42 (-2.2A)
ZN  A  42 (-2.3A)
ZN  A  42 (-3.1A)
 0.89A 3dtuB-4cykA:
undetectable		 3dtuB-4cykA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus) 		PF00480
(ROK) 		3 CYH A 179
CYH A 184
HIS A 157
 ZN  A 401 (-2.3A)
ZN  A 401 (-2.2A)
ZN  A 401 (-3.2A)
 0.76A 3dtuB-4db3A:
undetectable		 3dtuB-4db3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4w DNA MISMATCH REPAIR
PROTEIN MLH1
DNA MISMATCH REPAIR
PROTEIN PMS1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF16413
(Mlh1_C)
PF08676
(MutL_C) 		3 CYH B 817
CYH A 769
HIS B 850
 ZN  B 901 (-2.4A)
ZN  B 902 ( 2.2A)
ZN  B 902 (-3.1A)
 0.80A 3dtuB-4e4wB:
undetectable		 3dtuB-4e4wB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM

(Sulfolobus
solfataricus) 		no annotation 3 CYH B 171
CYH B 149
HIS B 144
 ZN  B 701 (-2.1A)
ZN  B 701 (-2.3A)
ZN  B 701 (-3.2A)
 0.76A 3dtuB-4fdgB:
undetectable		 3dtuB-4fdgB:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE

(Mus musculus) 		PF13091
(PLDc_2) 		3 CYH A  66
CYH A  49
HIS A  72
 ZN  A 301 (-2.2A)
ZN  A 301 (-2.2A)
ZN  A 301 (-3.3A)
 0.73A 3dtuB-4ggjA:
undetectable		 3dtuB-4ggjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1s NON-STRUCTURAL
PROTEIN V

(Mammalian
rubulavirus 5) 		PF13008
(zf-Paramyx-P) 		3 CYH B 215
CYH B 190
HIS B 171
 ZN  B 302 (-2.2A)
ZN  B 302 (-2.4A)
ZN  B 302 (-3.0A)
 0.83A 3dtuB-4i1sB:
undetectable		 3dtuB-4i1sB:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lj0 NAB2

(Chaetomium
thermophilum) 		PF14608
(zf-CCCH_2) 		3 CYH A 437
CYH A 426
HIS A 441
 ZN  A 502 (-2.2A)
A  E   2 (-2.1A)
ZN  A 502 (-3.2A)
 0.87A 3dtuB-4lj0A:
undetectable		 3dtuB-4lj0A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1j CARBONIC ANHYDRASE

(Sordaria
macrospora) 		PF00484
(Pro_CA) 		3 CYH A  45
CYH A 104
HIS A 101
 ZN  A 301 (-2.2A)
ZN  A 301 (-2.3A)
ZN  A 301 (-3.4A)
 0.88A 3dtuB-4o1jA:
undetectable		 3dtuB-4o1jA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1k CARBONIC ANHYDRASE

(Sordaria
macrospora) 		PF00484
(Pro_CA) 		3 CYH A  56
CYH A 115
HIS A 112
 ZN  A 301 (-2.3A)
ZN  A 301 (-2.2A)
ZN  A 301 (-3.3A)
 0.89A 3dtuB-4o1kA:
undetectable		 3dtuB-4o1kA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogr PROTEIN TAT

(Human
immunodeficiency
virus 1) 		PF00539
(Tat) 		3 CYH D  22
CYH D  34
HIS D  33
 ZN  D 101 (-2.2A)
ZN  D 101 (-2.4A)
ZN  D 101 (-3.1A)
 0.86A 3dtuB-4ogrD:
undetectable		 3dtuB-4ogrD:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozu CORONIN

(Toxoplasma
gondii) 		PF00400
(WD40)
PF08953
(DUF1899)
PF16300
(WD40_4) 		3 CYH A 210
CYH A 217
HIS A 211
 None
None
TRS  A 401 (-3.8A)
 0.89A 3dtuB-4ozuA:
undetectable		 3dtuB-4ozuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 CYH A 171
CYH A 149
HIS A 144
 ZN  A2003 (-2.1A)
ZN  A2003 (-2.2A)
ZN  A2003 (-3.1A)
 0.57A 3dtuB-4r7yA:
undetectable		 3dtuB-4r7yA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvo PHENYLACETATE-COENZY
ME A LIGASE

(Bacteroides
thetaiotaomicron) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		3 CYH A 313
CYH A 251
HIS A 258
 ZN  A 501 (-2.4A)
ZN  A 501 (-2.3A)
ZN  A 501 (-3.2A)
 0.88A 3dtuB-4rvoA:
undetectable		 3dtuB-4rvoA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8h CRYPTOCHROME-2
PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus musculus;
Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
PF12114
(Period_C) 		3 CYH A 432
CYH B1213
HIS A 491
 ZN  A2000 (-2.7A)
ZN  A2000 (-4.2A)
ZN  A2000 (-3.3A)
 0.85A 3dtuB-4u8hA:
undetectable		 3dtuB-4u8hA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w9z CYTOCHROME C OXIDASE
SUBUNIT 2

(Bradyrhizobium
diazoefficiens) 		PF00116
(COX2) 		3 CYH A 229
CYH A 233
HIS A 237
 CU  A 302 ( 2.3A)
CU  A 302 ( 2.2A)
CU  A 302 (-3.1A)
 0.14A 3dtuB-4w9zA:
21.5		 3dtuB-4w9zA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3c SIR2 FAMILY PROTEIN

(Streptococcus
pyogenes) 		no annotation 3 CYH A 180
CYH A 149
HIS A 150
 ZN  A1293 (-2.0A)
ZN  A1293 (-2.3A)
None
 0.78A 3dtuB-5a3cA:
undetectable		 3dtuB-5a3cA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5z PTLCIB4 H88A MUTANT

(Phaeodactylum
tricornutum) 		no annotation 3 CYH A  46
CYH A 126
HIS A 102
 ZN  A 500 (-2.2A)
ZN  A 500 (-2.3A)
ZN  A 500 (-3.3A)
 0.87A 3dtuB-5b5zA:
undetectable		 3dtuB-5b5zA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqk ICP27

(Human
alphaherpesvirus
1) 		PF05459
(Herpes_UL69) 		3 CYH A 400
CYH A 483
HIS A 479
 ZN  A 601 (-2.1A)
ZN  A 601 (-2.3A)
ZN  A 601 (-3.2A)
 0.81A 3dtuB-5bqkA:
undetectable		 3dtuB-5bqkA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7r LMO0178 PROTEIN

(Listeria
monocytogenes) 		no annotation 3 CYH E 256
CYH E 261
HIS E 244
 ZN  E 503 (-2.2A)
ZN  E 503 (-2.3A)
ZN  E 503 ( 3.1A)
 0.77A 3dtuB-5f7rE:
undetectable		 3dtuB-5f7rE:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		3 CYH A 823
CYH A 897
HIS A 798
 ZN  A1702 (-2.2A)
ZN  A1702 (-2.2A)
None
 0.87A 3dtuB-5gutA:
undetectable		 3dtuB-5gutA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7s E3 UBIQUITIN-PROTEIN
LIGASE LNX

(Homo sapiens) 		no annotation 3 CYH D  95
CYH D 118
HIS D 113
 ZN  D 204 (-2.3A)
ZN  D 204 (-2.3A)
ZN  D 204 (-3.2A)
 0.77A 3dtuB-5h7sD:
undetectable		 3dtuB-5h7sD:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB

(Chlamydomonas
reinhardtii) 		no annotation 3 CYH A 120
CYH A 204
HIS A 180
 ZN  A 500 (-2.3A)
ZN  A 500 (-2.3A)
ZN  A 500 (-3.3A)
 0.86A 3dtuB-5k5wA:
undetectable		 3dtuB-5k5wA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2l NAB2P

(Saccharomyces
cerevisiae) 		PF14608
(zf-CCCH_2) 		3 CYH A 469
CYH A 458
HIS A 473
 ZN  A 503 (-2.3A)
ZN  A 503 (-2.3A)
ZN  A 503 (-3.3A)
 0.87A 3dtuB-5l2lA:
undetectable		 3dtuB-5l2lA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRE-MRNA-SPLICING
FACTOR BUD31

(Saccharomyces
cerevisiae) 		PF01125
(G10) 		3 CYH L 145
CYH L 108
HIS L 147
 ZN  L1002 (-2.6A)
ZN  L1002 ( 2.2A)
U  V  29 ( 4.2A)
 0.84A 3dtuB-5lj3L:
undetectable		 3dtuB-5lj3L:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1

(Homo sapiens) 		PF01485
(IBR) 		3 CYH B 372
CYH B 389
HIS B 382
 ZN  B 602 (-2.4A)
ZN  B 602 (-2.4A)
ZN  B 602 (-3.2A)
 0.88A 3dtuB-5tteB:
undetectable		 3dtuB-5tteB:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1

(Homo sapiens) 		PF01485
(IBR) 		3 CYH A 281
CYH A 297
HIS A 283
 ZN  A 603 (-2.2A)
ZN  A 603 (-2.2A)
None
 0.83A 3dtuB-5udhA:
undetectable		 3dtuB-5udhA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wuq ANTI-SIGMA-W FACTOR
RSIW

(Bacillus
subtilis) 		PF13490
(zf-HC2) 		3 CYH C   3
CYH C  37
HIS C  30
 ZN  C 301 (-2.3A)
ZN  C 301 (-2.3A)
ZN  C 301 (-3.7A)
 0.73A 3dtuB-5wuqC:
undetectable		 3dtuB-5wuqC:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6m MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 5

(Mus musculus) 		no annotation 3 CYH B  65
CYH B 110
HIS B 127
 ZN  B 201 (-3.0A)
ZN  B 201 (-2.1A)
ZN  B 201 (-3.0A)
 0.60A 3dtuB-5x6mB:
undetectable		 3dtuB-5x6mB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 CYH C1135
CYH C1176
HIS C1175
 None
 0.72A 3dtuB-5y3rC:
undetectable		 3dtuB-5y3rC:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 3 CYH A 333
CYH A 427
HIS A 423
 ZN  A 500 (-2.3A)
ZN  A 500 (-2.3A)
ZN  A 500 (-3.3A)
 0.84A 3dtuB-5zb3A:
undetectable		 3dtuB-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9atc ASPARTATE
TRANSCARBAMOYLASE

(Escherichia
coli) 		PF01948
(PyrI)
PF02748
(PyrI_C) 		3 CYH B 109
CYH B 114
HIS B 117
 ZN  B   1 (-2.3A)
ZN  B   1 (-2.2A)
None
 0.78A 3dtuB-9atcB:
undetectable		 3dtuB-9atcB:
20.95