SIMILAR PATTERNS OF AMINO ACIDS FOR 3DL9_B_V2HB602_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE

(Moorella
thermoacetica) 		PF01268
(FTHFS) 		5 VAL A1378
ALA A1377
ALA A1332
ILE A1060
THR A1429
 None
 1.28A 3dl9B-1eg7A:
0.0		 3dl9B-1eg7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyq CELL DIVISION
INHIBITOR (MIND-1)

(Archaeoglobus
fulgidus) 		PF01656
(CbiA) 		5 VAL A   7
ALA A 157
GLU A 135
ILE A 232
THR A  20
 None
 1.13A 3dl9B-1hyqA:
0.0		 3dl9B-1hyqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqg CARBOXYPEPTIDASE A

(Helicoverpa
armigera) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 THR A  75
ALA A 254
ALA A 111
GLU A  72
THR A 164
 None
None
None
ZN  A 413 (-2.4A)
None
 1.25A 3dl9B-1jqgA:
0.0		 3dl9B-1jqgA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		5 VAL A 262
ALA A 261
ALA A 387
ILE A 339
THR A 301
 None
 1.29A 3dl9B-1jqkA:
0.0		 3dl9B-1jqkA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158

(Thermotoga
maritima) 		PF00117
(GATase) 		5 MET A 181
THR A 180
VAL A 134
ALA A 206
ILE A  87
 None
None
None
None
OCS  A  88 ( 4.0A)
 1.12A 3dl9B-1o1yA:
0.0		 3dl9B-1o1yA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ALA A 167
GLU A 159
THR A 174
ILE A 279
THR A 171
 None
 1.26A 3dl9B-1oi7A:
undetectable		 3dl9B-1oi7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E

(Streptococcus
pyogenes) 		PF01515
(PTA_PTB) 		5 VAL A  32
ALA A  35
ALA A 127
THR A  60
ILE A  71
 None
 1.27A 3dl9B-1r5jA:
undetectable		 3dl9B-1r5jA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrm LACTALDEHYDE
REDUCTASE

(Escherichia
coli) 		PF00465
(Fe-ADH) 		5 THR A 214
ASN A 256
ALA A 145
ALA A 201
ILE A 150
 None
 1.04A 3dl9B-1rrmA:
0.0		 3dl9B-1rrmA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		6 ALA A 214
ALA A 226
GLU A 207
THR A  92
ILE A 150
THR A 184
 None
 1.46A 3dl9B-1ryyA:
0.0		 3dl9B-1ryyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 MET A   1
VAL A  17
ALA A  21
ALA A  50
ILE A  30
 None
 1.22A 3dl9B-1rzmA:
undetectable		 3dl9B-1rzmA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE

(Mytilus edulis) 		PF13714
(PEP_mutase) 		5 PHE A 202
VAL A 160
ALA A 158
GLU A 177
ILE A 135
 None
 1.20A 3dl9B-1s2tA:
undetectable		 3dl9B-1s2tA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u89 TALIN 1

(Mus musculus) 		no annotation 5 VAL A 774
ALA A 773
GLU A 810
ILE A 812
THR A 867
 None
 1.30A 3dl9B-1u89A:
undetectable		 3dl9B-1u89A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 VAL A 123
ALA A 122
ALA A 163
MET A 126
THR A 127
 None
 1.27A 3dl9B-1xhlA:
undetectable		 3dl9B-1xhlA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsf PROBABLE
RESUSCITATION-PROMOT
ING FACTOR RPFB

(Mycobacterium
tuberculosis) 		PF06737
(Transglycosylas) 		5 VAL A  55
ALA A  35
ALA A  44
GLU A  81
THR A  89
 None
 1.27A 3dl9B-1xsfA:
undetectable		 3dl9B-1xsfA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		5 ASN A  77
VAL A  24
ALA A  28
ALA A 626
THR A  17
 None
 1.06A 3dl9B-2b0tA:
undetectable		 3dl9B-2b0tA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF10433
(MMS1_N) 		5 ALA A 557
ALA A 539
THR A 640
MET A 593
THR A 594
 None
 1.29A 3dl9B-2b5nA:
undetectable		 3dl9B-2b5nA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bji INOSITOL-1(OR
4)-MONOPHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		5 THR A1161
VAL A1238
ALA A1210
GLU A1213
ILE A1269
 None
 1.21A 3dl9B-2bjiA:
undetectable		 3dl9B-2bjiA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1w ENDOU PROTEIN

(Xenopus laevis) 		PF09412
(XendoU) 		5 VAL A 114
ALA A 118
GLU A 238
MET A 115
THR A 112
 None
 1.30A 3dl9B-2c1wA:
undetectable		 3dl9B-2c1wA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4w GLYCEROL KINASE

(Cellulomonas
sp.) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ASN A 187
VAL A 168
ALA A  99
THR A 173
ILE A 243
 None
 1.26A 3dl9B-2d4wA:
undetectable		 3dl9B-2d4wA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh7 NUCLEOLYSIN TIAR

(Homo sapiens) 		PF00076
(RRM_1) 		5 THR A 170
PHE A 120
ALA A 126
ALA A 151
ILE A 108
 None
 1.04A 3dl9B-2dh7A:
undetectable		 3dl9B-2dh7A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 THR A 119
ALA A 138
ALA A 131
GLU A 115
ILE A 222
 None
 1.24A 3dl9B-2ehqA:
undetectable		 3dl9B-2ehqA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq1 ISOCHORISMATASE

(Escherichia
coli) 		PF00550
(PP-binding)
PF00857
(Isochorismatase) 		5 ASN A  20
VAL A 174
ALA A 175
ALA A 161
MET A 202
 None
 1.23A 3dl9B-2fq1A:
undetectable		 3dl9B-2fq1A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		5 MET A 226
VAL A 155
ALA A 158
ALA A 184
ILE A 271
 None
 1.00A 3dl9B-2fuqA:
undetectable		 3dl9B-2fuqA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 VAL A 546
ALA A 548
ALA A 555
ILE A 607
THR A 636
 None
 1.12A 3dl9B-2g5tA:
undetectable		 3dl9B-2g5tA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caldanaerobacter
subterraneus) 		PF13407
(Peripla_BP_4) 		5 PHE A 165
ALA A 195
ALA A 163
ILE A 234
THR A 218
 RIP  A 401 (-3.4A)
None
None
None
None
 1.23A 3dl9B-2ioyA:
undetectable		 3dl9B-2ioyA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE

(Streptococcus
sp.) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 VAL A  33
ALA A 437
ALA A  39
ILE A  28
THR A 231
 None
None
None
FAD  A 609 (-4.8A)
None
 1.22A 3dl9B-2rghA:
undetectable		 3dl9B-2rghA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgw PEROXIDE RESISTANCE
PROTEIN

(Streptococcus
pyogenes) 		PF00210
(Ferritin) 		5 VAL A  31
ALA A  30
ALA A  37
ILE A  86
THR A 139
 None
 1.28A 3dl9B-2xgwA:
undetectable		 3dl9B-2xgwA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		5 THR A 192
PHE A 311
VAL A 315
ALA A 316
ALA A  77
 ACT  A1327 ( 4.1A)
None
None
None
ACT  A1327 ( 3.5A)
 1.30A 3dl9B-2yp1A:
undetectable		 3dl9B-2yp1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG

(Mycobacterium
tuberculosis) 		PF01474
(DAHP_synth_2) 		5 VAL A 124
ALA A 125
ALA A 110
GLU A 242
THR A 278
 None
None
TRP  A1464 (-3.6A)
GOL  A1469 (-4.7A)
None
 1.30A 3dl9B-2ypqA:
undetectable		 3dl9B-2ypqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0j PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1438

(Thermus
thermophilus) 		PF04029
(2-ph_phosp) 		5 THR A  96
VAL A  22
ALA A 103
ILE A  25
THR A 154
 None
 1.28A 3dl9B-2z0jA:
undetectable		 3dl9B-2z0jA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zmf CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF01590
(GAF) 		5 ASN A 342
VAL A 385
ALA A 278
ILE A 343
THR A 364
 None
None
None
None
CMP  A2001 (-2.8A)
 1.24A 3dl9B-2zmfA:
undetectable		 3dl9B-2zmfA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		5 MET A 207
ALA A  54
ALA A  67
THR A 190
ILE A  38
 None
 1.17A 3dl9B-3bn1A:
undetectable		 3dl9B-3bn1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqw PUTATIVE CAPSID
PROTEIN OF PROPHAGE

(Escherichia
coli) 		PF03864
(Phage_cap_E) 		5 VAL A 141
ALA A 140
ALA A 134
ILE A 208
THR A 145
 None
 1.30A 3dl9B-3bqwA:
undetectable		 3dl9B-3bqwA:
21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		5 MET A 118
THR A 119
ALA A 250
THR A 191
THR A 312
 VD3  A 701 ( 3.9A)
None
VD3  A 701 (-3.3A)
HEM  A 601 ( 4.1A)
None
 1.18A 3dl9B-3c6gA:
62.7		 3dl9B-3c6gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		12 MET A 118
THR A 119
ASN A 126
PHE A 214
VAL A 218
ALA A 221
ALA A 250
GLU A 306
THR A 314
ILE A 379
MET A 487
THR A 488
 VD3  A 701 ( 3.9A)
None
VD3  A 701 (-4.2A)
VD3  A 701 (-4.6A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 3.8A)
VD3  A 701 (-3.3A)
VD3  A 701 ( 4.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.1A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 4.6A)
 0.19A 3dl9B-3c6gA:
62.7		 3dl9B-3c6gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4l PUTATIVE
OXIDOREDUCTASE YHHX

(Escherichia
coli) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ASN A 325
VAL A 223
ALA A 212
ALA A 171
ILE A 184
 None
 1.28A 3dl9B-3f4lA:
undetectable		 3dl9B-3f4lA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hij DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
anthracis) 		PF00701
(DHDPS) 		5 VAL A 254
ALA A 257
ALA A 248
THR A   9
ILE A 212
 None
 1.20A 3dl9B-3hijA:
undetectable		 3dl9B-3hijA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imh GALACTOSE-1-EPIMERAS
E

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		5 VAL A 264
ALA A 253
ALA A 268
GLU A 297
ILE A 294
 None
None
None
GOL  A 341 (-2.6A)
None
 1.22A 3dl9B-3imhA:
undetectable		 3dl9B-3imhA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2w BETAINE-ALDEHYDE
DEHYDROGENASE

(Pseudoalteromonas
atlantica) 		PF00171
(Aldedh) 		5 ASN A 284
ALA A 161
ALA A  91
THR A 182
THR A 154
 None
 1.14A 3dl9B-3k2wA:
undetectable		 3dl9B-3k2wA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN

(Escherichia
coli) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30) 		5 THR D 175
VAL D 156
ALA D 158
THR D 335
THR D 333
 None
 1.22A 3dl9B-3k70D:
undetectable		 3dl9B-3k70D:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		5 THR A1321
VAL A1231
ALA A1236
GLU A1225
ILE A1139
 None
 1.07A 3dl9B-3k9bA:
undetectable		 3dl9B-3k9bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
SULFITE REDCUTASE
SUBUNIT BETA

(Desulfovibrio
gigas;
Desulfovibrio
gigas) 		PF01077
(NIR_SIR)
PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 ASN B 291
ALA A 235
ALA A 325
THR B  97
ILE B 289
 None
None
None
SRM  B 581 (-3.7A)
SRM  B 581 (-4.2A)
 1.24A 3dl9B-3or2B:
undetectable		 3dl9B-3or2B:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osu 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Staphylococcus
aureus) 		PF13561
(adh_short_C2) 		5 THR A  10
ASN A  88
ALA A  32
ILE A 121
MET A 128
 None
 1.28A 3dl9B-3osuA:
undetectable		 3dl9B-3osuA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		5 MET A 315
VAL A 349
ALA A 311
GLU A 357
THR A 380
 None
 1.29A 3dl9B-3p27A:
undetectable		 3dl9B-3p27A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rao PUTATIVE
LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		5 PHE A   5
ALA A  68
ALA A  29
GLU A  37
THR A 110
 None
 1.27A 3dl9B-3raoA:
undetectable		 3dl9B-3raoA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00701
(DHDPS) 		5 ASN A 191
VAL A 135
ALA A 133
THR A 115
THR A 118
 None
 1.03A 3dl9B-3s5nA:
undetectable		 3dl9B-3s5nA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Toxoplasma
gondii) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL A  91
ALA A 115
ALA A 331
THR A  74
ILE A  84
 None
 1.30A 3dl9B-3sthA:
undetectable		 3dl9B-3sthA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syb GLYCINE-GLUTAMATE
DIPEPTIDE PORIN OPDP

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		5 VAL A  86
ALA A 105
THR A 453
ILE A  22
THR A  47
 None
 1.27A 3dl9B-3sybA:
undetectable		 3dl9B-3sybA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgw V-TYPE ATP SYNTHASE
BETA CHAIN

(Methanosarcina
mazei) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 VAL A 367
ALA A 366
ALA A 373
THR A 425
ILE A 355
 None
 1.30A 3dl9B-3tgwA:
undetectable		 3dl9B-3tgwA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcs ERYTHROAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 THR A 173
ALA A 143
ALA A 199
THR A 233
ILE A 168
 None
 1.21A 3dl9B-3wcsA:
undetectable		 3dl9B-3wcsA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wva UPF0254 PROTEIN
MJ1251

(Methanocaldococcus
jannaschii) 		PF06787
(UPF0254) 		5 THR A  11
PHE A 129
ALA A  94
ALA A 117
THR A 122
 None
 0.95A 3dl9B-3wvaA:
undetectable		 3dl9B-3wvaA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxx AOPB

(Aeromonas
hydrophila) 		PF04888
(SseC) 		5 VAL B 255
ALA B 178
GLU B 231
ILE B 171
THR B 259
 None
 1.09A 3dl9B-3wxxB:
undetectable		 3dl9B-3wxxB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		5 PHE A 360
THR A 298
ILE A 427
MET A 334
THR A 333
 None
 1.17A 3dl9B-4aeeA:
undetectable		 3dl9B-4aeeA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 PHE A 366
VAL A 426
ALA A 429
ALA A 344
THR A  34
 None
 1.19A 3dl9B-4bhtA:
undetectable		 3dl9B-4bhtA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bms ALCLOHOL
DEHYDROGENASE/SHORT-
CHAIN DEHYDROGENASE

(Ralstonia sp.
DSMZ 6428) 		PF13561
(adh_short_C2) 		5 THR A 247
PHE A 205
VAL A 214
ALA A 208
THR A 185
 None
None
None
None
NAP  A1250 (-2.6A)
 1.12A 3dl9B-4bmsA:
undetectable		 3dl9B-4bmsA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE,
IRON-SULFUR PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD) 		5 VAL B 113
ALA B 116
ALA B 146
GLU B 109
THR B  56
 None
 1.30A 3dl9B-4c1nB:
undetectable		 3dl9B-4c1nB:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Paraburkholderia
xenovorans) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 VAL A  88
ALA A 129
ALA A 145
THR A  61
THR A  90
 None
 1.26A 3dl9B-4dfeA:
undetectable		 3dl9B-4dfeA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewj ENOLASE 2

(Streptococcus
suis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 VAL A  68
ALA A  76
GLU A  24
THR A  20
THR A  64
 None
 1.24A 3dl9B-4ewjA:
undetectable		 3dl9B-4ewjA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eye PROBABLE
OXIDOREDUCTASE

(Mycobacteroides
abscessus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 THR A 225
ALA A 147
ALA A 218
ILE A 186
THR A 176
 None
 1.13A 3dl9B-4eyeA:
undetectable		 3dl9B-4eyeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eye PROBABLE
OXIDOREDUCTASE

(Mycobacteroides
abscessus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 THR A 225
VAL A 170
ALA A 147
ALA A 218
THR A 176
 None
IOD  A 403 ( 4.4A)
None
None
None
 1.21A 3dl9B-4eyeA:
undetectable		 3dl9B-4eyeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Pyrococcus
horikoshii) 		PF01680
(SOR_SNZ)
PF05690
(ThiG) 		5 VAL A  48
ALA A  45
THR A  32
ILE A  39
MET A  29
 None
 1.29A 3dl9B-4firA:
undetectable		 3dl9B-4firA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fq7 MALEATE CIS-TRANS
ISOMERASE

(Pseudomonas
putida) 		no annotation 5 MET A  20
THR A  19
ALA A 226
ALA A  81
ILE A 197
 None
 0.89A 3dl9B-4fq7A:
undetectable		 3dl9B-4fq7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huj UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored) 		5 VAL A  62
ALA A   5
ALA A  90
ILE A  25
THR A   2
 None
 1.29A 3dl9B-4hujA:
undetectable		 3dl9B-4hujA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inf METAL-DEPENDENT
HYDROLASE

(Novosphingobium
aromaticivorans) 		PF04909
(Amidohydro_2) 		5 MET A 310
THR A 287
ALA A 345
GLU A  19
THR A 130
 None
None
None
CA  A 401 (-3.3A)
None
 1.29A 3dl9B-4infA:
undetectable		 3dl9B-4infA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxk OXIDOREDUCTASE

(Rhodococcus
opacus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 174
VAL A 137
ALA A 139
ALA A 218
GLU A 146
 None
 1.24A 3dl9B-4jxkA:
undetectable		 3dl9B-4jxkA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Mycobacterium
tuberculosis) 		PF04452
(Methyltrans_RNA) 		5 VAL A 240
ALA A 239
ALA A 232
ILE A 186
THR A 244
 None
 1.12A 3dl9B-4l69A:
undetectable		 3dl9B-4l69A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 THR A 486
ASN A  84
ALA A 479
ILE A  86
THR A 511
 None
None
ACT  A 601 (-3.5A)
None
None
 1.26A 3dl9B-4l7tA:
undetectable		 3dl9B-4l7tA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		5 MET A 292
THR A 269
ALA A 169
ALA A 327
GLU A   7
 None
None
None
None
MN  A 401 ( 3.3A)
 1.20A 3dl9B-4ng3A:
undetectable		 3dl9B-4ng3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		5 MET A 292
THR A 269
ALA A 327
GLU A   7
THR A 115
 None
None
None
MN  A 401 ( 3.3A)
None
 1.18A 3dl9B-4ng3A:
undetectable		 3dl9B-4ng3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q82 PHOSPHOLIPASE/CARBOX
YLESTERASE

(Haliangium
ochraceum) 		no annotation 5 THR A 197
ALA A 212
ALA A 153
ILE A 225
THR A 241
 None
 1.29A 3dl9B-4q82A:
undetectable		 3dl9B-4q82A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 MET A 237
PHE A 256
VAL A 331
ALA A 334
ALA A 259
 None
 1.11A 3dl9B-4u33A:
undetectable		 3dl9B-4u33A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr3 ALANINE RACEMASE,
BIOSYNTHETIC

(Escherichia
coli) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 VAL A   7
ALA A  12
GLU A 327
ILE A 323
THR A   5
 None
 1.28A 3dl9B-4wr3A:
undetectable		 3dl9B-4wr3A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 5 PHE A 100
ALA A 196
ALA A  96
THR A  41
THR A 134
 None
 1.25A 3dl9B-4xj6A:
undetectable		 3dl9B-4xj6A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yx8 DSBA-LIKE PROTEIN

(Proteus
mirabilis) 		PF13462
(Thioredoxin_4) 		5 VAL A 128
ALA A  63
THR A 162
ILE A 155
THR A 164
 None
 1.21A 3dl9B-4yx8A:
undetectable		 3dl9B-4yx8A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaa FDC1

(Aspergillus
niger) 		PF01977
(UbiD) 		5 PHE A  10
VAL A 215
ALA A 212
ALA A 309
ILE A 171
 None
None
None
None
FZZ  A 602 ( 3.7A)
 1.16A 3dl9B-4zaaA:
undetectable		 3dl9B-4zaaA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum) 		PF01912
(eIF-6) 		5 THR I 210
VAL I 199
ALA I 204
ILE I 221
THR I 155
 None
 1.26A 3dl9B-5anbI:
undetectable		 3dl9B-5anbI:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		5 THR A  66
VAL A 265
ALA A  95
THR A 259
THR A 255
 None
 1.29A 3dl9B-5c6uA:
undetectable		 3dl9B-5c6uA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol) 		5 PHE C 583
VAL C 585
ALA C 612
THR C 745
ILE C 557
 None
 1.30A 3dl9B-5exrC:
undetectable		 3dl9B-5exrC:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7v LMO0181 PROTEIN

(Listeria
monocytogenes) 		PF01547
(SBP_bac_1) 		5 THR A 150
VAL A 242
ALA A 243
ALA A 264
GLU A 174
 None
 1.15A 3dl9B-5f7vA:
undetectable		 3dl9B-5f7vA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 VAL A 264
ALA A 261
ALA A  10
GLU A 269
THR A 154
 None
 1.23A 3dl9B-5fbzA:
undetectable		 3dl9B-5fbzA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 VAL A 336
ALA A 335
ALA A 328
MET A 339
THR A 340
 None
 1.08A 3dl9B-5fjiA:
undetectable		 3dl9B-5fjiA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiw CYTOCHROME P450
CYP260B1

(Sorangium
cellulosum) 		PF00067
(p450) 		5 THR A 232
VAL A  73
THR A  62
ILE A 278
THR A  60
 HEM  A 401 (-3.7A)
HEM  A 401 (-3.6A)
None
HEM  A 401 (-3.5A)
None
 1.30A 3dl9B-5hiwA:
29.3		 3dl9B-5hiwA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1

(Mus musculus) 		PF01094
(ANF_receptor) 		5 THR A 356
ASN A 350
VAL A  76
ALA A  79
ALA A 108
 None
 1.13A 3dl9B-5kc9A:
undetectable		 3dl9B-5kc9A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 THR B 494
VAL B 219
ALA B 217
ALA B 504
THR B  93
 None
 1.24A 3dl9B-5khnB:
undetectable		 3dl9B-5khnB:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 VAL B 815
ALA B 640
ALA B 624
THR B 821
ILE B 889
 None
 1.30A 3dl9B-5nd1B:
undetectable		 3dl9B-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi) 		PF00883
(Peptidase_M17) 		5 VAL A 155
ALA A 154
ALA A 118
GLU A 515
THR A 205
 None
 1.09A 3dl9B-5ntfA:
undetectable		 3dl9B-5ntfA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN

(Tick-borne
encephalitis
virus) 		no annotation 5 THR A 359
VAL A 385
ALA A 355
THR A 313
ILE A 364
 None
 1.25A 3dl9B-5o6vA:
undetectable		 3dl9B-5o6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8y EPOXYQUEUOSINE
REDUCTASE

(Bacillus
subtilis) 		PF08331
(DUF1730)
PF13484
(Fer4_16)
PF13646
(HEAT_2) 		5 THR A 174
VAL A 143
ALA A 147
ALA A  27
ILE A  73
 None
 1.20A 3dl9B-5t8yA:
undetectable		 3dl9B-5t8yA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacterium
smegmatis) 		PF01261
(AP_endonuc_2) 		5 VAL A 198
ALA A 197
GLU A 158
THR A 120
ILE A 107
 None
 1.29A 3dl9B-5tnvA:
undetectable		 3dl9B-5tnvA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp4 AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Burkholderia
ambifaria) 		PF01546
(Peptidase_M20) 		5 THR A 117
VAL A 183
ALA A 185
ALA A  76
ILE A  81
 None
 1.28A 3dl9B-5tp4A:
undetectable		 3dl9B-5tp4A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN

(Yersinia pestis) 		PF01042
(Ribonuc_L-PSP) 		5 VAL A  77
ALA A 109
GLU A  24
THR A  30
THR A 130
 None
 1.30A 3dl9B-5v4fA:
undetectable		 3dl9B-5v4fA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4p NADPH DEHYDROGENASE
3

(Saccharomyces
cerevisiae) 		no annotation 5 THR A  73
ALA A 183
ALA A 176
THR A  25
ILE A 104
 None
 1.22A 3dl9B-5v4pA:
undetectable		 3dl9B-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN

(Human
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		5 VAL A 115
ALA A 228
ALA A  74
THR A 144
ILE A 176
 None
 1.16A 3dl9B-5vylA:
undetectable		 3dl9B-5vylA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 5 VAL A 221
ALA A 257
ALA A 213
ILE A 278
THR A 261
 None
 1.02A 3dl9B-5w19A:
undetectable		 3dl9B-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 5 THR A 173
PHE A 407
VAL A 353
ALA A 369
THR A 351
 SAM  A 601 (-3.2A)
None
None
None
None
 1.26A 3dl9B-5ybbA:
undetectable		 3dl9B-5ybbA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwr -

(-) 		no annotation 5 THR A 131
PHE A 165
ALA A 186
ALA A 159
THR A  31
 None
 1.29A 3dl9B-6cwrA:
undetectable		 3dl9B-6cwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfp VCA0883

(Vibrio cholerae) 		no annotation 5 THR A  35
VAL A 155
ALA A 158
ALA A  57
ILE A 179
 None
 1.28A 3dl9B-6dfpA:
undetectable		 3dl9B-6dfpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekv TOXIN COMPLEX
COMPONENT ORF-X2

(Clostridium
botulinum) 		no annotation 5 MET A 186
THR A 185
ALA A 340
THR A 177
ILE A 712
 None
 1.17A 3dl9B-6ekvA:
undetectable		 3dl9B-6ekvA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 5 VAL D 457
ALA D 461
ALA D 479
THR D 453
ILE D 468
 None
 1.17A 3dl9B-6f5dD:
undetectable		 3dl9B-6f5dD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5

(Mus musculus) 		no annotation 5 VAL L 315
ALA L 398
THR L 284
ILE L 257
MET L 277
 None
 1.20A 3dl9B-6g2jL:
undetectable		 3dl9B-6g2jL:
undetectable