SIMILAR PATTERNS OF AMINO ACIDS FOR 3DL9_A_V2HA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		4 ASN A 172
ALA A 145
LEU A 349
GLY A 178
 None
 0.94A 3dl9A-1cvrA:
0.0		 3dl9A-1cvrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwu ENOYL ACP REDUCTASE

(Brassica napus) 		PF13561
(adh_short_C2) 		4 ALA A 258
LEU A 264
GLY A 234
THR A 288
 None
 0.92A 3dl9A-1cwuA:
0.0		 3dl9A-1cwuA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3e ALCOHOL
DEHYDROGENASE, CLASS
II

(Mus musculus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASN A 317
ALA A 282
GLY A 291
THR A 194
 None
 0.80A 3dl9A-1e3eA:
0.0		 3dl9A-1e3eA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT

(Mus musculus) 		PF03129
(HGTP_anticodon) 		4 ALA A 183
LEU A 159
GLY A 186
THR A 320
 None
 0.94A 3dl9A-1g5iA:
undetectable		 3dl9A-1g5iA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE

(Escherichia
coli) 		PF00764
(Arginosuc_synth) 		4 ALA A 352
LEU A 306
GLY A 357
THR A 252
 None
 0.93A 3dl9A-1kp2A:
0.0		 3dl9A-1kp2A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m41 FMNH2-DEPENDENT
ALKANESULFONATE
MONOOXYGENASE

(Escherichia
coli) 		PF00296
(Bac_luciferase) 		4 ASN A 105
ALA A  61
LEU A  71
GLY A  45
 None
 0.96A 3dl9A-1m41A:
0.0		 3dl9A-1m41A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7s CATALASE

(Pseudomonas
syringae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ASN A 386
ALA A 359
LEU A 366
GLY A 370
 None
 0.87A 3dl9A-1m7sA:
0.0		 3dl9A-1m7sA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdw CALPAIN II,
CATALYTIC SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		4 ALA A 212
LEU A 338
GLY A 239
THR A 115
 None
 0.97A 3dl9A-1mdwA:
undetectable		 3dl9A-1mdwA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 ASN B 245
ALA B 185
LEU B 162
GLY B 251
 None
 0.97A 3dl9A-1mhyB:
1.7		 3dl9A-1mhyB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		4 ALA K  42
LEU K 214
GLY K 217
THR K  59
 None
IOD  K1904 ( 4.4A)
IOD  K1904 (-4.2A)
None
 0.74A 3dl9A-1oxxK:
undetectable		 3dl9A-1oxxK:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanopyrus
kandleri) 		PF02289
(MCH) 		4 ALA A 287
LEU A 253
GLY A 188
THR A  82
 None
 0.86A 3dl9A-1qlmA:
undetectable		 3dl9A-1qlmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 XYLANASE INHIBITOR
PROTEIN I

(Triticum
aestivum) 		PF00704
(Glyco_hydro_18) 		4 ASN A 147
ALA A 214
LEU A 176
THR A   9
 None
 0.90A 3dl9A-1ta3A:
undetectable		 3dl9A-1ta3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		4 ASN C 100
ALA C 108
LEU C  40
GLY C  57
 None
 0.89A 3dl9A-1wa5C:
undetectable		 3dl9A-1wa5C:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 ALA A  97
LEU A 719
GLY A 517
THR A 429
 None
 0.85A 3dl9A-1yr2A:
undetectable		 3dl9A-1yr2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0k GTP-BINDING PROTEIN
FYVE-FINGER-CONTAINI
NG RAB5 EFFECTOR
PROTEIN RABENOSYN-5

(Homo sapiens;
Homo sapiens) 		PF00071
(Ras)
PF11464
(Rbsn) 		4 ASN B 488
ALA B 473
GLY A  46
THR A  40
 None
None
None
MG  A1201 ( 3.1A)
 0.88A 3dl9A-1z0kB:
undetectable		 3dl9A-1z0kB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 ASN A 150
ALA A 119
LEU A 127
GLY A  94
 None
 0.94A 3dl9A-2c4kA:
undetectable		 3dl9A-2c4kA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6w PENICILLIN-BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 ASN B 365
ALA B 347
LEU B 327
GLY B 598
THR B 371
 None
 1.26A 3dl9A-2c6wB:
undetectable		 3dl9A-2c6wB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 4 ASN A 158
ALA A 139
GLY A 164
THR A 105
 None
 0.83A 3dl9A-2cl2A:
undetectable		 3dl9A-2cl2A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fp7 GENOME POLYPROTEIN

(West Nile virus) 		PF00949
(Peptidase_S7) 		4 ALA B  38
LEU B  49
GLY B 151
THR B 111
 None
 0.96A 3dl9A-2fp7B:
undetectable		 3dl9A-2fp7B:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 ALA A 112
LEU A 115
GLY A  54
THR A  26
 None
 0.86A 3dl9A-2genA:
undetectable		 3dl9A-2genA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ii1 ACETAMIDASE

(Bacillus
halodurans) 		PF03069
(FmdA_AmdA) 		4 ALA A 241
LEU A 264
GLY A 268
THR A 223
 None
 0.97A 3dl9A-2ii1A:
undetectable		 3dl9A-2ii1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ii1 ACETAMIDASE

(Bacillus
halodurans) 		PF03069
(FmdA_AmdA) 		4 ASN A 144
ALA A 178
LEU A 168
GLY A 152
 None
 0.79A 3dl9A-2ii1A:
undetectable		 3dl9A-2ii1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		4 ALA A  10
LEU A  84
GLY A  77
THR A 293
 ATP  A1327 ( 3.7A)
None
None
None
 0.93A 3dl9A-2ivpA:
undetectable		 3dl9A-2ivpA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jft SER-THR PHOSPHATASE
MSPP

(Mycolicibacterium
smegmatis) 		PF13672
(PP2C_2) 		4 ASN A  19
ALA A  46
GLY A  36
THR A  85
 None
None
MG  A 301 (-4.1A)
None
 0.93A 3dl9A-2jftA:
undetectable		 3dl9A-2jftA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASN A 213
ALA A 222
LEU A 259
THR A 308
 None
 0.97A 3dl9A-2jiiA:
undetectable		 3dl9A-2jiiA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbk NEUROTOXIN BMK-M10

(Mesobuthus
martensii) 		PF00537
(Toxin_3) 		4 ASN A  29
ALA A   4
GLY A  34
THR A  19
 None
 0.96A 3dl9A-2kbkA:
undetectable		 3dl9A-2kbkA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxp UBIQUITIN-CONJUGATIN
G ENZYME E2 G2

(Homo sapiens) 		PF00179
(UQ_con) 		4 ASN A  33
LEU A  16
GLY A  27
THR A  74
 None
 0.88A 3dl9A-2lxpA:
undetectable		 3dl9A-2lxpA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 ALA A 199
LEU A 204
GLY A 243
THR A 252
 None
None
None
HEM  A 501 (-3.4A)
 0.77A 3dl9A-2m56A:
30.5		 3dl9A-2m56A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2

(Homo sapiens) 		PF00027
(cNMP_binding) 		4 ASN A 151
ALA A  68
LEU A  65
GLY A 106
 None
 0.94A 3dl9A-2n7gA:
undetectable		 3dl9A-2n7gA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quy PENICILLIN ACYLASE

(Lysinibacillus
sphaericus) 		PF02275
(CBAH) 		4 ASN A 288
ALA A  53
LEU A  67
GLY A  56
 None
 0.87A 3dl9A-2quyA:
undetectable		 3dl9A-2quyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ASN A 143
ALA A 120
GLY A 155
THR A 178
 None
 0.93A 3dl9A-2vdaA:
undetectable		 3dl9A-2vdaA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmy PUTATIVE ACID
PHOSPHATASE WZB

(Escherichia
coli) 		PF01451
(LMWPc) 		4 ALA A  57
LEU A 135
GLY A  23
THR A  70
 None
 0.77A 3dl9A-2wmyA:
undetectable		 3dl9A-2wmyA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE

(Bacillus
subtilis) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 ASN A 465
ALA A  81
LEU A  74
GLY A  58
 None
 0.95A 3dl9A-2x7jA:
undetectable		 3dl9A-2x7jA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y75 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYMR

(Bacillus
subtilis) 		PF02082
(Rrf2) 		4 ALA A  77
LEU A  84
GLY A  11
THR A  27
 None
 0.93A 3dl9A-2y75A:
undetectable		 3dl9A-2y75A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 ASN A 271
ALA A  44
GLY A  22
THR A 408
 None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.2A)
None
 0.86A 3dl9A-2z5xA:
undetectable		 3dl9A-2z5xA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		4 ASN A 531
ALA A 356
GLY A 582
THR A 271
 None
None
None
GOL  A 914 (-3.9A)
 0.77A 3dl9A-3a21A:
undetectable		 3dl9A-3a21A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		4 ALA A  37
LEU A  30
GLY A 250
THR A  84
 None
 0.80A 3dl9A-3a9xA:
undetectable		 3dl9A-3a9xA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b90 ENDO-PECTATE LYASE

(Dickeya
chrysanthemi) 		PF03211
(Pectate_lyase) 		4 ASN A 213
ALA A 197
LEU A 153
GLY A 171
 CA  A 701 (-3.0A)
None
None
None
 0.96A 3dl9A-3b90A:
undetectable		 3dl9A-3b90A:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		5 ASN A 126
ALA A 250
LEU A 257
GLY A 305
THR A 314
 VD3  A 701 (-4.2A)
VD3  A 701 (-3.3A)
None
VD3  A 701 ( 3.9A)
HEM  A 601 (-3.4A)
 0.13A 3dl9A-3c6gA:
65.3		 3dl9A-3c6gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcl TM1086

(Thermotoga
maritima) 		PF14505
(DUF4438) 		4 ALA A 134
LEU A   8
GLY A 138
THR A 260
 None
 0.91A 3dl9A-3dclA:
undetectable		 3dl9A-3dclA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0l GUANINE DEAMINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ASN A 258
LEU A 311
GLY A 278
THR A 273
 None
 0.87A 3dl9A-3e0lA:
undetectable		 3dl9A-3e0lA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 ALA C  49
LEU C  42
GLY C 262
THR C  96
 None
 0.73A 3dl9A-3gzdC:
undetectable		 3dl9A-3gzdC:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4l DNA MISMATCH REPAIR
PROTEIN PMS1

(Saccharomyces
cerevisiae) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		4 ALA A 138
LEU A 185
GLY A  49
THR A 109
 None
 0.87A 3dl9A-3h4lA:
undetectable		 3dl9A-3h4lA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 ALA A 412
LEU A  39
GLY A  53
THR A  30
 None
 0.94A 3dl9A-3hpaA:
undetectable		 3dl9A-3hpaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr8 PROTEIN RECA

(Thermotoga
maritima) 		PF00154
(RecA) 		4 ALA A  48
LEU A 336
GLY A  56
THR A 222
 None
 0.96A 3dl9A-3hr8A:
undetectable		 3dl9A-3hr8A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iib PEPTIDASE M28

(Shewanella
amazonensis) 		PF04389
(Peptidase_M28) 		4 ASN A 442
ALA A 411
LEU A 276
GLY A 278
 None
 0.77A 3dl9A-3iibA:
undetectable		 3dl9A-3iibA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE

(Coxiella
burnetii) 		PF00883
(Peptidase_M17) 		4 ASN A 281
ALA A 157
LEU A 165
GLY A 227
 None
 0.95A 3dl9A-3ij3A:
undetectable		 3dl9A-3ij3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksd GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
1

(Staphylococcus
aureus) 		no annotation 4 ASN Q 265
ALA Q 294
LEU Q 291
GLY Q 272
 None
 0.94A 3dl9A-3ksdQ:
undetectable		 3dl9A-3ksdQ:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6u ABC-TYPE SUGAR
TRANSPORT SYSTEM
PERIPLASMIC
COMPONENT

(Exiguobacterium
sibiricum) 		PF13407
(Peripla_BP_4) 		4 ALA A 244
LEU A 234
GLY A 229
THR A 276
 None
 0.84A 3dl9A-3l6uA:
undetectable		 3dl9A-3l6uA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		4 ASN A 179
ALA A 198
GLY A 190
THR A 264
 None
 0.93A 3dl9A-3mpnA:
undetectable		 3dl9A-3mpnA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwo PROLINE
IMINOPEPTIDASE

(Mycolicibacterium
smegmatis) 		PF00561
(Abhydrolase_1) 		4 ASN A  48
ALA A 209
GLY A  44
THR A  19
 None
 0.92A 3dl9A-3nwoA:
undetectable		 3dl9A-3nwoA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oj0 GLUTAMYL-TRNA
REDUCTASE

(Thermoplasma
volcanium) 		PF01488
(Shikimate_DH) 		4 ASN A  50
ALA A  58
LEU A  23
GLY A  25
 None
None
None
SO4  A 149 ( 4.0A)
 0.84A 3dl9A-3oj0A:
undetectable		 3dl9A-3oj0A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmk NUCLEOCAPSID PROTEIN

(Recombinant
vesicular
stomatitis
Indiana virus
rVSV-G/GFP) 		PF00945
(Rhabdo_ncap) 		4 ALA A 397
LEU A 404
GLY A 413
THR A 230
 None
 0.84A 3dl9A-3pmkA:
undetectable		 3dl9A-3pmkA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		4 ASN A 173
ALA A  33
GLY A 321
THR A 118
 None
None
Q9C  A 401 (-3.6A)
None
 0.82A 3dl9A-3q9cA:
undetectable		 3dl9A-3q9cA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)

(Leishmania
infantum) 		PF00215
(OMPdecase) 		4 ASN A 138
LEU A 184
GLY A 177
THR A 109
 None
 0.94A 3dl9A-3qw3A:
undetectable		 3dl9A-3qw3A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		4 ALA A 246
LEU A  46
GLY A 108
THR A 255
 None
 0.95A 3dl9A-3rv6A:
undetectable		 3dl9A-3rv6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		4 ASN A  45
ALA A 167
GLY A   9
THR A  94
 GOL  A 401 (-3.9A)
None
None
None
 0.89A 3dl9A-3ry7A:
undetectable		 3dl9A-3ry7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u27 MICROCOMPARTMENTS
PROTEIN

(Leptotrichia
buccalis) 		no annotation 4 ASN C  18
ALA C  93
LEU C  99
GLY C  37
 None
 0.96A 3dl9A-3u27C:
undetectable		 3dl9A-3u27C:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		4 ASN A  63
ALA A 166
LEU A 171
GLY A 135
 None
 0.96A 3dl9A-3wc3A:
undetectable		 3dl9A-3wc3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ALA A 161
LEU A 164
GLY A  89
THR A 119
 None
ADP  A1441 ( 4.9A)
None
None
 0.95A 3dl9A-3zl8A:
undetectable		 3dl9A-3zl8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		4 ALA A 107
LEU A  90
GLY A 246
THR A 167
 None
 0.96A 3dl9A-3zvtA:
undetectable		 3dl9A-3zvtA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnx SULFATE
ADENYLYLTRANSFERASE

(Allochromatium
vinosum) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ALA A  40
LEU A  47
GLY A  57
THR A  74
 None
 0.85A 3dl9A-4dnxA:
undetectable		 3dl9A-4dnxA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 ALA A  74
LEU A  81
GLY A  28
THR A  47
 None
 0.94A 3dl9A-4dqdA:
undetectable		 3dl9A-4dqdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6f UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14730
(DUF4468) 		4 ALA A  97
LEU A  76
GLY A 100
THR A 178
 None
None
EDO  A 403 (-4.7A)
None
 0.86A 3dl9A-4e6fA:
undetectable		 3dl9A-4e6fA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		4 ALA A 213
LEU A 268
GLY A 284
THR A 293
 None
 0.97A 3dl9A-4fidA:
undetectable		 3dl9A-4fidA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanobrevibacter
ruminantium) 		PF02289
(MCH) 		4 ALA A 291
LEU A 257
GLY A 190
THR A  84
 None
 0.78A 3dl9A-4fioA:
undetectable		 3dl9A-4fioA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gw9 BACTERIOPHYTOCHROME

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF00989
(PAS)
PF01590
(GAF)
PF08446
(PAS_2) 		4 ALA A  50
LEU A 247
GLY A  35
THR A 103
 None
 0.97A 3dl9A-4gw9A:
undetectable		 3dl9A-4gw9A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv5 ASPARTATE
CARBAMOYLTRANSFERASE
, PUTATIVE

(Trypanosoma
cruzi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ASN A 292
ALA A 267
LEU A 227
THR A 175
 None
 0.94A 3dl9A-4iv5A:
undetectable		 3dl9A-4iv5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1m ENOYL-ACYL CARRIER
REDUCTASE

(Toxoplasma
gondii) 		PF13561
(adh_short_C2) 		4 ALA A 255
LEU A 261
GLY A 225
THR A 285
 None
 0.95A 3dl9A-4o1mA:
undetectable		 3dl9A-4o1mA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4osp OXYGENASE-REDUCTASE

(Streptomyces
fradiae) 		PF13561
(adh_short_C2) 		4 ASN A 154
LEU A 113
GLY A 102
THR A 197
 None
 0.91A 3dl9A-4ospA:
undetectable		 3dl9A-4ospA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per ANGIOGENIN

(Gallus gallus) 		PF00074
(RnaseA) 		4 ASN B  57
LEU B  68
GLY B 103
THR B  11
 None
 0.96A 3dl9A-4perB:
undetectable		 3dl9A-4perB:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ALA A 372
LEU A 230
GLY A 190
THR A 182
 None
 0.97A 3dl9A-4uaqA:
undetectable		 3dl9A-4uaqA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zej METALLO-BETA-LACTAMA
SE

(Pseudomonas
stutzeri) 		no annotation 4 ALA A 183
LEU A 154
GLY A 156
THR A 102
 None
 0.94A 3dl9A-4zejA:
undetectable		 3dl9A-4zejA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ASN A 348
ALA A 310
LEU A  18
GLY A 266
 None
 0.90A 3dl9A-4zyjA:
undetectable		 3dl9A-4zyjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2o NITRATE TRANSPORTER
1.1

(Arabidopsis
thaliana) 		PF00854
(PTR2) 		5 ASN A 198
ALA A 385
LEU A 470
GLY A 391
THR A 481
 None
 1.39A 3dl9A-5a2oA:
undetectable		 3dl9A-5a2oA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b13 PHYCOERYTHRIN ALPHA
SUBUNIT
PHYCOERYTHRIN BETA
SUBUNIT

(Palmaria
palmata;
Palmaria
palmata) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		4 ASN G  11
ALA G  26
LEU A  38
THR A   6
 None
 0.94A 3dl9A-5b13G:
undetectable		 3dl9A-5b13G:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ALA A 166
LEU A 125
GLY A 127
THR A  75
 None
 0.87A 3dl9A-5cwaA:
undetectable		 3dl9A-5cwaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		4 ALA A 208
LEU A 200
GLY A 254
THR A 248
 None
 0.87A 3dl9A-5e31A:
undetectable		 3dl9A-5e31A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		4 ASN A 404
ALA A 178
LEU A 156
THR A 353
 5MV  A1201 (-3.5A)
None
None
5MV  A1201 (-3.8A)
 0.78A 3dl9A-5ee7A:
undetectable		 3dl9A-5ee7A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 ALA A 279
LEU A 591
GLY A 625
THR A  85
 None
 0.95A 3dl9A-5enoA:
undetectable		 3dl9A-5enoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erp DESMOCOLLIN-2

(Homo sapiens) 		PF00028
(Cadherin) 		4 ASN A 304
LEU A 261
GLY A 301
THR A 221
 CA  A 816 (-2.8A)
None
None
None
 0.92A 3dl9A-5erpA:
undetectable		 3dl9A-5erpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i32 AQUAPORIN TIP2-1

(Arabidopsis
thaliana) 		PF00230
(MIP) 		4 ALA A  39
LEU A  56
GLY A 189
THR A 150
 None
 0.88A 3dl9A-5i32A:
undetectable		 3dl9A-5i32A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF

(Thermus
thermophilus) 		no annotation 4 ALA F 749
LEU F 769
GLY F 771
THR F 658
 None
 0.90A 3dl9A-5it5F:
undetectable		 3dl9A-5it5F:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5d 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00701
(DHDPS) 		4 ALA A 280
LEU A 289
GLY A 263
THR A  17
 None
 0.83A 3dl9A-5j5dA:
undetectable		 3dl9A-5j5dA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 ASN A 203
ALA A 237
LEU A 232
THR A 249
 None
 0.96A 3dl9A-5kc8A:
undetectable		 3dl9A-5kc8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncr TYROSINE PHOSPHATASE

(Orf virus) 		PF00782
(DSPc) 		4 ALA A 114
LEU A  37
GLY A 120
THR A  16
 PO4  A 200 (-3.5A)
None
None
None
 0.95A 3dl9A-5ncrA:
undetectable		 3dl9A-5ncrA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ASN A 553
ALA A 350
LEU A 343
GLY A 577
 None
 0.88A 3dl9A-5t9gA:
undetectable		 3dl9A-5t9gA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE

(Streptococcus
mutans) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASN A 266
ALA A 115
LEU A  32
GLY A  12
 None
FAD  A 501 (-3.7A)
None
FAD  A 501 ( 4.9A)
 0.93A 3dl9A-5v36A:
undetectable		 3dl9A-5v36A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viq MONOMERIC
NEAR-INFRARED
FLUORESCENT PROTEIN
MIRFP709

(Rhodopseudomonas
palustris) 		PF01590
(GAF)
PF08446
(PAS_2) 		4 ALA A  50
LEU A 247
GLY A  35
THR A 103
 None
 0.92A 3dl9A-5viqA:
undetectable		 3dl9A-5viqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT

(Oryctolagus
cuniculus) 		no annotation 4 ASN B 532
ALA B 540
LEU B 258
GLY B 264
 None
 0.83A 3dl9A-5w7aB:
undetectable		 3dl9A-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7c ACYLOXYACYL
HYDROLASE

(Homo sapiens) 		no annotation 4 ASN C 532
ALA C 540
LEU C 259
GLY C 265
 None
 0.87A 3dl9A-5w7cC:
undetectable		 3dl9A-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 4 ASN A 531
ALA A 539
LEU A 258
GLY A 264
 None
 0.87A 3dl9A-5w7dA:
undetectable		 3dl9A-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpw 11S GLOBULIN ISOFORM
1

(Cocos nucifera) 		no annotation 4 ASN A 306
ALA A 395
LEU A 402
THR A 415
 None
 0.95A 3dl9A-5wpwA:
undetectable		 3dl9A-5wpwA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme)
PF02793
(HRM) 		4 ASN A 404
ALA A 178
LEU A 156
THR A 353
 97V  A1208 (-2.9A)
None
None
97V  A1208 (-3.3A)
 0.77A 3dl9A-5xezA:
undetectable		 3dl9A-5xezA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9h SAFD,PUTATIVE OUTER
MEMBRANE
PROTEIN,PUTATIVE
OUTER MEMBRANE
PROTEIN,PUTATIVE
OUTER MEMBRANE
PROTEIN

(Salmonella
enterica) 		no annotation 4 ASN A 115
ALA A 139
LEU A 142
GLY A  59
 None
 0.84A 3dl9A-5y9hA:
undetectable		 3dl9A-5y9hA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III

(Komagataella
phaffii) 		no annotation 4 ASN A  39
ALA A 149
LEU A 155
GLY A  92
 None
 0.94A 3dl9A-5yatA:
undetectable		 3dl9A-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Pyrococcus
horikoshii) 		no annotation 4 ASN A  73
ALA A 203
GLY A  25
THR A  64
 None
None
RI2  A 401 (-3.5A)
None
 0.86A 3dl9A-5yg7A:
undetectable		 3dl9A-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 ASN A 615
LEU A 603
GLY A 608
THR A 745
 None
 0.96A 3dl9A-5zqzA:
undetectable		 3dl9A-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 5 ASN 2 358
ALA 2 284
LEU 2 341
GLY 2 350
THR 2 253
 None
 1.32A 3dl9A-5zvs2:
undetectable		 3dl9A-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml INO80

(Chaetomium
thermophilum) 		no annotation 4 ALA G1662
LEU G1626
GLY G1631
THR G1032
 None
 0.95A 3dl9A-6fmlG:
undetectable		 3dl9A-6fmlG:
undetectable