SIMILAR PATTERNS OF AMINO ACIDS FOR 3DL9_A_V2HA602_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al3 CYS REGULON
TRANSCRIPTIONAL
ACTIVATOR CYSB

(Klebsiella
aerogenes) 		PF03466
(LysR_substrate) 		5 VAL A  97
ALA A 143
VAL A 122
ILE A 272
THR A  99
 None
 1.09A 3dl9A-1al3A:
0.0		 3dl9A-1al3A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b24 PROTEIN (I-DMOI)

(Desulfurococcus
mucosus) 		PF14528
(LAGLIDADG_3) 		5 ALA A 116
VAL A 160
TYR A 161
ILE A  18
THR A  41
 None
 1.14A 3dl9A-1b24A:
0.0		 3dl9A-1b24A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		5 THR A 142
VAL A  76
VAL A  40
ILE A 162
THR A  46
 None
 1.10A 3dl9A-1e5dA:
0.0		 3dl9A-1e5dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE
ARSENITE OXIDASE

(Alcaligenes
faecalis;
Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF00355
(Rieske) 		5 MET A  69
THR A  70
ALA B 100
VAL A  63
VAL B 121
 None
 1.23A 3dl9A-1g8kA:
0.0		 3dl9A-1g8kA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 PHE A  87
ALA A  92
VAL A  41
ILE A 157
THR A 170
 None
 1.17A 3dl9A-1gg4A:
0.0		 3dl9A-1gg4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpp ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae) 		PF05203
(Hom_end_hint) 		5 THR A   6
PHE A 444
VAL A 451
VAL A  27
VAL A  83
 None
 1.09A 3dl9A-1gppA:
undetectable		 3dl9A-1gppA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guz MALATE DEHYDROGENASE

(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A   5
VAL A  58
VAL A 117
ILE A 115
THR A  76
 None
None
NAD  A1306 (-4.2A)
None
None
 1.10A 3dl9A-1guzA:
0.0		 3dl9A-1guzA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ALA A  22
GLU A  65
VAL A  75
ILE A  15
THR A  31
 None
 1.03A 3dl9A-1hvcA:
0.0		 3dl9A-1hvcA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 VAL A 794
ALA A 797
TYR A 618
ILE A 874
THR A 867
 None
 1.17A 3dl9A-1jqoA:
undetectable		 3dl9A-1jqoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jyh DNA GYRASE
INHIBITORY PROTEIN

(Escherichia
coli) 		PF06445
(GyrI-like) 		5 PHE A 131
ALA A  97
VAL A  48
GLU A   8
ILE A   5
 None
 1.21A 3dl9A-1jyhA:
undetectable		 3dl9A-1jyhA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF10282
(Lactonase) 		5 ALA A 280
VAL A 284
ILE A  17
MET A 282
THR A 267
 None
None
None
None
YCM  A 265 ( 3.5A)
 1.23A 3dl9A-1l0qA:
undetectable		 3dl9A-1l0qA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 THR A  71
ALA A  14
VAL A 102
VAL A 147
THR A 145
 None
 1.23A 3dl9A-1mb9A:
undetectable		 3dl9A-1mb9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxj RNA-BINDING PROTEIN
SMAUG

(Drosophila
melanogaster) 		PF00536
(SAM_1)
PF09246
(PHAT) 		5 VAL A 678
ALA A 677
VAL A 685
ILE A 710
THR A 682
 None
 1.21A 3dl9A-1oxjA:
undetectable		 3dl9A-1oxjA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)

(Pseudomonas
mevalonii) 		PF00368
(HMG-CoA_red) 		5 VAL A 360
ALA A 363
TYR A 294
VAL A  75
ILE A  70
 None
 1.18A 3dl9A-1qaxA:
undetectable		 3dl9A-1qaxA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE

(Mytilus edulis) 		PF13714
(PEP_mutase) 		5 PHE A 202
VAL A 160
ALA A 158
GLU A 177
ILE A 135
 None
 1.22A 3dl9A-1s2tA:
undetectable		 3dl9A-1s2tA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2f L-LACTATE
DEHYDROGENASE B
CHAIN

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A 135
VAL A  31
VAL A 146
ILE A 142
THR A 147
 None
NAD  A 401 (-3.7A)
None
None
None
 1.16A 3dl9A-1t2fA:
undetectable		 3dl9A-1t2fA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkh PUTATIVE SERINE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF07859
(Abhydrolase_3) 		5 VAL A 192
ALA A 195
GLU A 183
VAL A 147
ILE A 119
 None
 1.24A 3dl9A-1vkhA:
undetectable		 3dl9A-1vkhA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkb LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 MET A 440
VAL A 322
ALA A 227
VAL A 325
MET A 323
 None
 1.19A 3dl9A-1wkbA:
undetectable		 3dl9A-1wkbA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 THR A 115
ALA A 200
VAL A  67
VAL A 193
THR A 195
 None
NDP  A1278 ( 4.5A)
NDP  A1278 (-3.9A)
NDP  A1278 (-3.8A)
NDP  A1278 (-2.8A)
 1.21A 3dl9A-1xhlA:
undetectable		 3dl9A-1xhlA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 THR A 117
ALA A 202
VAL A  67
VAL A 195
THR A 197
 None
NDP  A1281 ( 4.2A)
NDP  A1281 (-3.9A)
NDP  A1281 (-4.1A)
NDP  A1281 (-3.2A)
 1.25A 3dl9A-1xkqA:
undetectable		 3dl9A-1xkqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 VAL A 125
ALA A 124
VAL A 132
MET A 128
THR A 129
 None
 1.17A 3dl9A-1xkqA:
undetectable		 3dl9A-1xkqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT

(Streptomyces
coelicolor) 		PF01039
(Carboxyl_trans) 		5 THR A 191
VAL A 101
ALA A 100
VAL A 251
ILE A 121
 None
 0.95A 3dl9A-1xnyA:
undetectable		 3dl9A-1xnyA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Actinobacillus
succinogenes) 		PF01293
(PEPCK_ATP) 		5 PHE A 193
VAL A 169
TYR A  71
GLU A 210
MET A 137
 None
 1.19A 3dl9A-1yggA:
undetectable		 3dl9A-1yggA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 VAL A  73
ALA A 228
VAL A 299
VAL A  56
THR A  57
 None
 1.17A 3dl9A-1zfjA:
undetectable		 3dl9A-1zfjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 THR A 299
ALA A 277
VAL A 127
ILE A  10
THR A 126
 None
None
None
FAD  A 666 (-4.7A)
None
 1.25A 3dl9A-1zk7A:
undetectable		 3dl9A-1zk7A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zof ALKYL
HYDROPEROXIDE-REDUCT
ASE

(Helicobacter
pylori) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 PHE A  63
VAL A  70
VAL A 156
VAL A  97
ILE A  53
 None
 1.19A 3dl9A-1zofA:
undetectable		 3dl9A-1zofA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajh LEUCYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF13603
(tRNA-synt_1_2) 		5 VAL A 261
ALA A 323
TYR A 330
ILE A 282
THR A 305
 None
 1.26A 3dl9A-2ajhA:
undetectable		 3dl9A-2ajhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7j SEP-TRNA:CYS-TRNA
SYNTHASE

(Archaeoglobus
fulgidus) 		PF05889
(SepSecS) 		5 VAL A 166
ALA A 170
VAL A 120
VAL A 193
ILE A 203
 None
 1.05A 3dl9A-2e7jA:
undetectable		 3dl9A-2e7jA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		5 THR A 441
VAL A 356
ALA A 392
VAL A 378
THR A 359
 None
 1.05A 3dl9A-2glfA:
undetectable		 3dl9A-2glfA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		5 ALA A 378
VAL A 448
GLU A 332
VAL A  54
ILE A 372
 None
 1.20A 3dl9A-2hg4A:
undetectable		 3dl9A-2hg4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		5 PHE A 303
VAL A 297
GLU A 189
ILE A 216
THR A 223
 None
 1.19A 3dl9A-2iuyA:
undetectable		 3dl9A-2iuyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nm0 PROBABLE
3-OXACYL-(ACYL-CARRI
ER-PROTEIN)
REDUCTASE

(Streptomyces
coelicolor) 		PF13561
(adh_short_C2) 		5 VAL A 226
VAL A 193
VAL A 208
ILE A 125
THR A 207
 None
 1.21A 3dl9A-2nm0A:
undetectable		 3dl9A-2nm0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3

(Mus musculus) 		PF03747
(ADP_ribosyl_GH) 		5 VAL A 261
ALA A 257
VAL A 233
VAL A 141
ILE A 176
 None
 1.12A 3dl9A-2qtyA:
undetectable		 3dl9A-2qtyA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 VAL A 327
ALA A 326
GLU A  23
VAL A   8
ILE A  10
 None
 1.07A 3dl9A-2qz9A:
undetectable		 3dl9A-2qz9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rck JUVENILE HORMONE
BINDING PROTEIN

(Galleria
mellonella) 		PF06585
(JHBP) 		5 THR A 158
VAL A  93
ALA A 122
VAL A 201
ILE A 197
 None
 1.14A 3dl9A-2rckA:
undetectable		 3dl9A-2rckA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 THR B 527
VAL B 540
ALA B 469
VAL B 511
ILE B 513
 XAX  B1778 ( 4.9A)
None
None
None
None
 0.99A 3dl9A-2w55B:
undetectable		 3dl9A-2w55B:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we5 CARBAMATE KINASE 1

(Enterococcus
faecalis) 		PF00696
(AA_kinase) 		5 VAL A 308
ALA A 287
GLU A 255
VAL A 234
THR A 306
 None
None
None
ADP  A1311 ( 3.9A)
None
 1.10A 3dl9A-2we5A:
undetectable		 3dl9A-2we5A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 5 VAL A 728
ALA A 726
VAL A 632
ILE A 748
MET A 743
 None
 1.17A 3dl9A-3a0fA:
undetectable		 3dl9A-3a0fA:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		12 MET A 118
THR A 119
PHE A 214
VAL A 218
ALA A 221
VAL A 253
TYR A 254
GLU A 306
VAL A 375
ILE A 379
MET A 487
THR A 488
 VD3  A 701 ( 3.9A)
None
VD3  A 701 (-4.6A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 3.8A)
VD3  A 701 ( 4.2A)
None
VD3  A 701 ( 4.8A)
HEM  A 601 ( 4.5A)
HEM  A 601 ( 4.1A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 4.6A)
 0.12A 3dl9A-3c6gA:
65.3		 3dl9A-3c6gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 VAL A 244
ALA A 258
VAL A 221
ILE A 268
THR A 242
 None
 1.25A 3dl9A-3cmvA:
undetectable		 3dl9A-3cmvA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 VAL A3244
ALA A3258
VAL A3221
ILE A3268
THR A3242
 None
 1.20A 3dl9A-3cmvA:
undetectable		 3dl9A-3cmvA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		5 VAL A 369
ALA A 370
VAL A 362
ILE A  23
THR A 365
 None
 1.05A 3dl9A-3cwcA:
undetectable		 3dl9A-3cwcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 VAL A 225
VAL A 193
VAL A 385
ILE A  42
THR A 384
 None
FAD  A 609 ( 3.8A)
None
None
None
 1.25A 3dl9A-3da1A:
undetectable		 3dl9A-3da1A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 VAL A 422
GLU A 377
VAL A 475
ILE A 201
THR A 473
 None
AT2  A 906 ( 2.7A)
None
None
None
 1.19A 3dl9A-3e7gA:
undetectable		 3dl9A-3e7gA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh0 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF04613
(LpxD)
PF14602
(Hexapep_2) 		5 ALA A 180
VAL A 241
VAL A 158
ILE A 160
THR A 176
 None
 1.25A 3dl9A-3eh0A:
undetectable		 3dl9A-3eh0A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ei8 LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 MET A 244
ALA A 215
VAL A 224
ILE A 252
THR A 221
 None
 1.21A 3dl9A-3ei8A:
undetectable		 3dl9A-3ei8A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		5 MET A 669
THR A 668
VAL A 418
VAL A 616
ILE A 648
 None
 1.23A 3dl9A-3j09A:
undetectable		 3dl9A-3j09A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00266
(Aminotran_5) 		5 MET A 252
VAL A  53
TYR A 248
VAL A 191
MET A 210
 None
 1.20A 3dl9A-3ke3A:
undetectable		 3dl9A-3ke3A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Ehrlichia
chaffeensis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 PHE A  56
VAL A  82
VAL A  63
VAL A  46
ILE A 269
 None
 1.23A 3dl9A-3l0gA:
undetectable		 3dl9A-3l0gA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE

(Thermococcus
sibiricus) 		PF00106
(adh_short) 		5 PHE A 173
VAL A 134
ALA A  85
VAL A 171
THR A 136
 None
 1.08A 3dl9A-3l77A:
undetectable		 3dl9A-3l77A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muj TRANSCRIPTION FACTOR
COE3

(Homo sapiens) 		PF01833
(TIG)
PF16423
(COE1_HLH) 		5 THR A 337
VAL A 272
ALA A 270
VAL A 315
GLU A 263
 None
 1.20A 3dl9A-3mujA:
undetectable		 3dl9A-3mujA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n28 PHOSPHOSERINE
PHOSPHATASE

(Vibrio cholerae) 		PF00702
(Hydrolase) 		5 THR A 298
VAL A 309
TYR A  95
ILE A 110
THR A 189
 None
 1.12A 3dl9A-3n28A:
undetectable		 3dl9A-3n28A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5f N-CARBAMOYL-L-AMINO
ACID HYDROLASE

(Geobacillus
stearothermophilus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 MET A 105
THR A 104
VAL A 118
GLU A 100
VAL A 203
 None
 1.25A 3dl9A-3n5fA:
undetectable		 3dl9A-3n5fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
ulcerans) 		PF13561
(adh_short_C2) 		5 VAL A  91
VAL A 183
GLU A 133
VAL A  37
THR A  13
 None
 1.02A 3dl9A-3svtA:
undetectable		 3dl9A-3svtA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubh NEURAL-CADHERIN

(Drosophila
melanogaster) 		PF00028
(Cadherin) 		6 PHE A 826
VAL A 846
ALA A 763
VAL A 828
ILE A 770
THR A 848
 None
 1.42A 3dl9A-3ubhA:
undetectable		 3dl9A-3ubhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 VAL A 477
ALA A 475
VAL A 513
VAL A 430
ILE A 432
 None
 1.06A 3dl9A-3vueA:
undetectable		 3dl9A-3vueA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 VAL A 206
GLU A  41
VAL A 198
ILE A  26
THR A 202
 None
None
SO4  A 706 (-3.5A)
None
SO4  A 706 (-3.1A)
 1.24A 3dl9A-3w1gA:
undetectable		 3dl9A-3w1gA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxx AOPB

(Aeromonas
hydrophila) 		PF04888
(SseC) 		5 VAL B 255
ALA B 178
GLU B 231
ILE B 171
THR B 259
 None
 1.06A 3dl9A-3wxxB:
undetectable		 3dl9A-3wxxB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8

(Homo sapiens) 		PF00400
(WD40) 		5 THR B 123
ALA B 135
VAL B 159
ILE B  90
THR B 129
 None
 1.14A 3dl9A-4a11B:
undetectable		 3dl9A-4a11B:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bps FKBO

(Streptomyces
hygroscopicus) 		no annotation 5 THR A 137
PHE A 158
ALA A 165
VAL A 141
TYR A 140
 None
 1.02A 3dl9A-4bpsA:
undetectable		 3dl9A-4bpsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 MET A 258
VAL A 207
ALA A 209
VAL A 292
VAL A 403
 None
 1.25A 3dl9A-4cj0A:
undetectable		 3dl9A-4cj0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 VAL H 263
ALA H 262
VAL H 375
GLU H 219
THR H 267
 None
 1.10A 3dl9A-4cr4H:
undetectable		 3dl9A-4cr4H:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7u ENDOGLUCANASE II

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		5 VAL A 110
VAL A 186
VAL A  58
ILE A 172
MET A 136
 None
 1.22A 3dl9A-4d7uA:
undetectable		 3dl9A-4d7uA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 THR A  24
PHE A  87
VAL A  20
VAL A  53
VAL A 324
 None
 1.25A 3dl9A-4dx3A:
undetectable		 3dl9A-4dx3A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1l ACETOACETYL-COA
THIOLASE 2

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 VAL A  27
ALA A  26
VAL A  34
ILE A  53
THR A  31
 None
 1.06A 3dl9A-4e1lA:
undetectable		 3dl9A-4e1lA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g76 PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF14859
(Colicin_M) 		5 PHE A 194
VAL A 192
VAL A 196
TYR A 198
THR A 190
 None
 1.07A 3dl9A-4g76A:
undetectable		 3dl9A-4g76A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvo LMO2349 PROTEIN

(Listeria
monocytogenes) 		PF00497
(SBP_bac_3) 		5 MET A 103
PHE A  45
VAL A  48
ILE A 195
THR A 182
 CSX  A 704 ( 4.4A)
HIS  A 703 ( 4.0A)
None
None
None
 1.25A 3dl9A-4gvoA:
undetectable		 3dl9A-4gvoA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 MET A  27
VAL A 165
ALA A 162
VAL A  40
GLU A  34
 None
 1.23A 3dl9A-4hkmA:
undetectable		 3dl9A-4hkmA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id3 DNA REPAIR PROTEIN
REV1

(Saccharomyces
cerevisiae) 		PF16589
(BRCT_2) 		5 VAL A 226
ALA A 210
VAL A 205
GLU A 220
THR A 250
 None
 1.21A 3dl9A-4id3A:
undetectable		 3dl9A-4id3A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		5 THR A 162
PHE A 127
VAL A 226
VAL A 296
ILE A 300
 None
 1.21A 3dl9A-4ipeA:
undetectable		 3dl9A-4ipeA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		5 PHE A 297
VAL A 135
VAL A  95
ILE A 276
THR A 119
 None
 1.12A 3dl9A-4joqA:
undetectable		 3dl9A-4joqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		5 VAL A 135
ALA A 136
VAL A  95
ILE A 276
THR A 119
 None
 1.11A 3dl9A-4joqA:
undetectable		 3dl9A-4joqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 THR A 347
VAL A 228
VAL A 293
ILE A 255
THR A 236
 None
 1.13A 3dl9A-4lbwA:
undetectable		 3dl9A-4lbwA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella suis) 		PF13561
(adh_short_C2) 		5 VAL A 226
VAL A 193
VAL A 208
ILE A 132
THR A 207
 None
 0.97A 3dl9A-4o6vA:
undetectable		 3dl9A-4o6vA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		5 THR A 215
ALA A 223
GLU A 217
VAL A 459
ILE A 250
 None
 1.15A 3dl9A-4p7hA:
undetectable		 3dl9A-4p7hA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 VAL A 292
VAL A 104
VAL A 159
ILE A 270
THR A 163
 None
 1.19A 3dl9A-4r6lA:
undetectable		 3dl9A-4r6lA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwl EXOGLUCANASE S

(Clostridium
cellulovorans) 		PF02011
(Glyco_hydro_48) 		5 THR A 622
ALA A 408
TYR A 419
VAL A 441
ILE A 525
 None
None
EDO  A 721 (-4.3A)
None
None
 1.18A 3dl9A-4xwlA:
undetectable		 3dl9A-4xwlA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwx SHC-TRANSFORMING
PROTEIN 1

(Homo sapiens) 		PF00640
(PID) 		5 THR A  78
ALA A 168
VAL A  85
VAL A 126
ILE A 194
 None
 1.24A 3dl9A-4xwxA:
undetectable		 3dl9A-4xwxA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af7 ACYL-COA
DEHYDROGENASE

(Advenella
mimigardefordensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 MET A  75
VAL A  41
VAL A  22
VAL A 160
ILE A 208
 None
 0.97A 3dl9A-5af7A:
undetectable		 3dl9A-5af7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum) 		PF01912
(eIF-6) 		5 THR I 210
VAL I 199
ALA I 204
ILE I 221
THR I 155
 None
 1.24A 3dl9A-5anbI:
undetectable		 3dl9A-5anbI:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 5 MET B 583
VAL B 542
ALA B 131
GLU B 139
VAL B  64
 None
 1.13A 3dl9A-5cyrB:
undetectable		 3dl9A-5cyrB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus;
Influenza C
virus) 		PF00603
(Flu_PA)
PF00602
(Flu_PB1) 		5 THR A 190
ALA B 223
VAL B 341
ILE B 181
THR B 149
 None
 1.23A 3dl9A-5d9aA:
undetectable		 3dl9A-5d9aA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 MET A 402
PHE A 344
ALA A 352
VAL A 629
ILE A 644
 None
 1.21A 3dl9A-5dfaA:
undetectable		 3dl9A-5dfaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp2 FERRIC ENTEROBACTIN
RECEPTOR PIRA

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 THR A  91
VAL A  95
VAL A 128
ILE A 131
THR A 155
 None
 1.20A 3dl9A-5fp2A:
undetectable		 3dl9A-5fp2A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 VAL A 621
VAL A 447
TYR A 418
VAL A 601
THR A 605
 None
 1.18A 3dl9A-5hjrA:
undetectable		 3dl9A-5hjrA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 ALA A 364
GLU A 348
VAL A 333
ILE A 308
THR A 371
 None
 1.17A 3dl9A-5ikpA:
undetectable		 3dl9A-5ikpA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixx ALR2278 PROTEIN

(Nostoc sp. PCC
7120) 		PF07700
(HNOB) 		5 VAL A   5
ALA A   8
VAL A 108
VAL A  52
THR A  48
 6EX  A 202 (-4.0A)
None
HEM  A 201 ( 4.7A)
None
None
 1.13A 3dl9A-5ixxA:
undetectable		 3dl9A-5ixxA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2o PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin) 		5 PHE A  10
VAL A  27
ALA A  93
VAL A   8
ILE A  54
 None
 1.07A 3dl9A-5m2oA:
undetectable		 3dl9A-5m2oA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 5 THR A  84
VAL A  88
VAL A 121
ILE A 124
THR A 148
 None
 1.10A 3dl9A-5mzsA:
undetectable		 3dl9A-5mzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2z PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ALA A  22
GLU A  65
VAL A  75
ILE A  15
THR A  31
 None
 1.00A 3dl9A-5t2zA:
undetectable		 3dl9A-5t2zA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Streptococcus
pyogenes;
Danio rerio) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		5 THR A 162
PHE A 127
VAL A 226
VAL A 296
ILE A 300
 None
 1.22A 3dl9A-5tthA:
undetectable		 3dl9A-5tthA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 5 THR A 234
VAL A 565
VAL A 395
VAL A 538
ILE A 560
 None
 1.24A 3dl9A-5vhaA:
undetectable		 3dl9A-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 5 VAL A 221
ALA A 257
VAL A 276
ILE A 278
THR A 261
 None
 0.85A 3dl9A-5w19A:
undetectable		 3dl9A-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 THR B 571
VAL B 575
VAL B 606
ILE B 608
THR B 621
 None
 1.13A 3dl9A-5xogB:
undetectable		 3dl9A-5xogB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivorans) 		no annotation 5 VAL A  71
ALA A  70
GLU A  90
VAL A 102
ILE A  81
 None
 1.20A 3dl9A-5yapA:
undetectable		 3dl9A-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjh PERIOSTIN

(Homo sapiens) 		no annotation 5 VAL A 108
ALA A 110
TYR A  56
VAL A 101
THR A 104
 None
MG  A 722 (-3.0A)
None
None
MG  A 720 (-3.1A)
 0.87A 3dl9A-5yjhA:
undetectable		 3dl9A-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 6 MET A 220
THR A 216
ALA A 296
TYR A 161
VAL A 563
THR A 572
 None
MG  A 606 ( 4.7A)
None
None
None
None
 1.40A 3dl9A-5ze4A:
undetectable		 3dl9A-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 5 VAL 2 654
ALA 2 658
GLU 2 614
VAL 2 633
ILE 2 414
 None
 1.17A 3dl9A-5zvs2:
undetectable		 3dl9A-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 5 VAL 2 654
ALA 2 658
VAL 2 551
VAL 2 633
ILE 2 414
 None
 1.14A 3dl9A-5zvs2:
undetectable		 3dl9A-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d14 TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		no annotation 5 THR A 162
PHE A 127
VAL A 226
VAL A 296
ILE A 300
 None
 1.20A 3dl9A-6d14A:
undetectable		 3dl9A-6d14A:
undetectable