SIMILAR PATTERNS OF AMINO ACIDS FOR 3DL9_A_V2HA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al3 CYS REGULON
TRANSCRIPTIONAL
ACTIVATOR CYSB

(Klebsiella
aerogenes) 		PF03466
(LysR_substrate) 		5 VAL A  97
ALA A 143
VAL A 122
ILE A 272
THR A  99
 None
 1.09A 3dl9A-1al3A:
0.0		 3dl9A-1al3A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b24 PROTEIN (I-DMOI)

(Desulfurococcus
mucosus) 		PF14528
(LAGLIDADG_3) 		5 ALA A 116
VAL A 160
TYR A 161
ILE A  18
THR A  41
 None
 1.14A 3dl9A-1b24A:
0.0		 3dl9A-1b24A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		5 THR A 142
VAL A  76
VAL A  40
ILE A 162
THR A  46
 None
 1.10A 3dl9A-1e5dA:
0.0		 3dl9A-1e5dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE
ARSENITE OXIDASE

(Alcaligenes
faecalis;
Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF00355
(Rieske) 		5 MET A  69
THR A  70
ALA B 100
VAL A  63
VAL B 121
 None
 1.23A 3dl9A-1g8kA:
0.0		 3dl9A-1g8kA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 PHE A  87
ALA A  92
VAL A  41
ILE A 157
THR A 170
 None
 1.17A 3dl9A-1gg4A:
0.0		 3dl9A-1gg4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpp ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae) 		PF05203
(Hom_end_hint) 		5 THR A   6
PHE A 444
VAL A 451
VAL A  27
VAL A  83
 None
 1.09A 3dl9A-1gppA:
undetectable		 3dl9A-1gppA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guz MALATE DEHYDROGENASE

(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A   5
VAL A  58
VAL A 117
ILE A 115
THR A  76
 None
None
NAD  A1306 (-4.2A)
None
None
 1.10A 3dl9A-1guzA:
0.0		 3dl9A-1guzA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ALA A  22
GLU A  65
VAL A  75
ILE A  15
THR A  31
 None
 1.03A 3dl9A-1hvcA:
0.0		 3dl9A-1hvcA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 VAL A 794
ALA A 797
TYR A 618
ILE A 874
THR A 867
 None
 1.17A 3dl9A-1jqoA:
undetectable		 3dl9A-1jqoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jyh DNA GYRASE
INHIBITORY PROTEIN

(Escherichia
coli) 		PF06445
(GyrI-like) 		5 PHE A 131
ALA A  97
VAL A  48
GLU A   8
ILE A   5
 None
 1.21A 3dl9A-1jyhA:
undetectable		 3dl9A-1jyhA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF10282
(Lactonase) 		5 ALA A 280
VAL A 284
ILE A  17
MET A 282
THR A 267
 None
None
None
None
YCM  A 265 ( 3.5A)
 1.23A 3dl9A-1l0qA:
undetectable		 3dl9A-1l0qA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 THR A  71
ALA A  14
VAL A 102
VAL A 147
THR A 145
 None
 1.23A 3dl9A-1mb9A:
undetectable		 3dl9A-1mb9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxj RNA-BINDING PROTEIN
SMAUG

(Drosophila
melanogaster) 		PF00536
(SAM_1)
PF09246
(PHAT) 		5 VAL A 678
ALA A 677
VAL A 685
ILE A 710
THR A 682
 None
 1.21A 3dl9A-1oxjA:
undetectable		 3dl9A-1oxjA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)

(Pseudomonas
mevalonii) 		PF00368
(HMG-CoA_red) 		5 VAL A 360
ALA A 363
TYR A 294
VAL A  75
ILE A  70
 None
 1.18A 3dl9A-1qaxA:
undetectable		 3dl9A-1qaxA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE

(Mytilus edulis) 		PF13714
(PEP_mutase) 		5 PHE A 202
VAL A 160
ALA A 158
GLU A 177
ILE A 135
 None
 1.22A 3dl9A-1s2tA:
undetectable		 3dl9A-1s2tA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2f L-LACTATE
DEHYDROGENASE B
CHAIN

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A 135
VAL A  31
VAL A 146
ILE A 142
THR A 147
 None
NAD  A 401 (-3.7A)
None
None
None
 1.16A 3dl9A-1t2fA:
undetectable		 3dl9A-1t2fA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkh PUTATIVE SERINE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF07859
(Abhydrolase_3) 		5 VAL A 192
ALA A 195
GLU A 183
VAL A 147
ILE A 119
 None
 1.24A 3dl9A-1vkhA:
undetectable		 3dl9A-1vkhA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkb LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 MET A 440
VAL A 322
ALA A 227
VAL A 325
MET A 323
 None
 1.19A 3dl9A-1wkbA:
undetectable		 3dl9A-1wkbA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 THR A 115
ALA A 200
VAL A  67
VAL A 193
THR A 195
 None
NDP  A1278 ( 4.5A)
NDP  A1278 (-3.9A)
NDP  A1278 (-3.8A)
NDP  A1278 (-2.8A)
 1.21A 3dl9A-1xhlA:
undetectable		 3dl9A-1xhlA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 THR A 117
ALA A 202
VAL A  67
VAL A 195
THR A 197
 None
NDP  A1281 ( 4.2A)
NDP  A1281 (-3.9A)
NDP  A1281 (-4.1A)
NDP  A1281 (-3.2A)
 1.25A 3dl9A-1xkqA:
undetectable		 3dl9A-1xkqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 VAL A 125
ALA A 124
VAL A 132
MET A 128
THR A 129
 None
 1.17A 3dl9A-1xkqA:
undetectable		 3dl9A-1xkqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT

(Streptomyces
coelicolor) 		PF01039
(Carboxyl_trans) 		5 THR A 191
VAL A 101
ALA A 100
VAL A 251
ILE A 121
 None
 0.95A 3dl9A-1xnyA:
undetectable		 3dl9A-1xnyA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Actinobacillus
succinogenes) 		PF01293
(PEPCK_ATP) 		5 PHE A 193
VAL A 169
TYR A  71
GLU A 210
MET A 137
 None
 1.19A 3dl9A-1yggA:
undetectable		 3dl9A-1yggA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 VAL A  73
ALA A 228
VAL A 299
VAL A  56
THR A  57
 None
 1.17A 3dl9A-1zfjA:
undetectable		 3dl9A-1zfjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 THR A 299
ALA A 277
VAL A 127
ILE A  10
THR A 126
 None
None
None
FAD  A 666 (-4.7A)
None
 1.25A 3dl9A-1zk7A:
undetectable		 3dl9A-1zk7A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zof ALKYL
HYDROPEROXIDE-REDUCT
ASE

(Helicobacter
pylori) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 PHE A  63
VAL A  70
VAL A 156
VAL A  97
ILE A  53
 None
 1.19A 3dl9A-1zofA:
undetectable		 3dl9A-1zofA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajh LEUCYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF13603
(tRNA-synt_1_2) 		5 VAL A 261
ALA A 323
TYR A 330
ILE A 282
THR A 305
 None
 1.26A 3dl9A-2ajhA:
undetectable		 3dl9A-2ajhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7j SEP-TRNA:CYS-TRNA
SYNTHASE

(Archaeoglobus
fulgidus) 		PF05889
(SepSecS) 		5 VAL A 166
ALA A 170
VAL A 120
VAL A 193
ILE A 203
 None
 1.05A 3dl9A-2e7jA:
undetectable		 3dl9A-2e7jA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		5 THR A 441
VAL A 356
ALA A 392
VAL A 378
THR A 359
 None
 1.05A 3dl9A-2glfA:
undetectable		 3dl9A-2glfA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		5 ALA A 378
VAL A 448
GLU A 332
VAL A  54
ILE A 372
 None
 1.20A 3dl9A-2hg4A:
undetectable		 3dl9A-2hg4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		5 PHE A 303
VAL A 297
GLU A 189
ILE A 216
THR A 223
 None
 1.19A 3dl9A-2iuyA:
undetectable		 3dl9A-2iuyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nm0 PROBABLE
3-OXACYL-(ACYL-CARRI
ER-PROTEIN)
REDUCTASE

(Streptomyces
coelicolor) 		PF13561
(adh_short_C2) 		5 VAL A 226
VAL A 193
VAL A 208
ILE A 125
THR A 207
 None
 1.21A 3dl9A-2nm0A:
undetectable		 3dl9A-2nm0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3

(Mus musculus) 		PF03747
(ADP_ribosyl_GH) 		5 VAL A 261
ALA A 257
VAL A 233
VAL A 141
ILE A 176
 None
 1.12A 3dl9A-2qtyA:
undetectable		 3dl9A-2qtyA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 VAL A 327
ALA A 326
GLU A  23
VAL A   8
ILE A  10
 None
 1.07A 3dl9A-2qz9A:
undetectable		 3dl9A-2qz9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rck JUVENILE HORMONE
BINDING PROTEIN

(Galleria
mellonella) 		PF06585
(JHBP) 		5 THR A 158
VAL A  93
ALA A 122
VAL A 201
ILE A 197
 None
 1.14A 3dl9A-2rckA:
undetectable		 3dl9A-2rckA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 THR B 527
VAL B 540
ALA B 469
VAL B 511
ILE B 513
 XAX  B1778 ( 4.9A)
None
None
None
None
 0.99A 3dl9A-2w55B:
undetectable		 3dl9A-2w55B:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we5 CARBAMATE KINASE 1

(Enterococcus
faecalis) 		PF00696
(AA_kinase) 		5 VAL A 308
ALA A 287
GLU A 255
VAL A 234
THR A 306
 None
None
None
ADP  A1311 ( 3.9A)
None
 1.10A 3dl9A-2we5A:
undetectable		 3dl9A-2we5A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 5 VAL A 728
ALA A 726
VAL A 632
ILE A 748
MET A 743
 None
 1.17A 3dl9A-3a0fA:
undetectable		 3dl9A-3a0fA:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		12 MET A 118
THR A 119
PHE A 214
VAL A 218
ALA A 221
VAL A 253
TYR A 254
GLU A 306
VAL A 375
ILE A 379
MET A 487
THR A 488
 VD3  A 701 ( 3.9A)
None
VD3  A 701 (-4.6A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 3.8A)
VD3  A 701 ( 4.2A)
None
VD3  A 701 ( 4.8A)
HEM  A 601 ( 4.5A)
HEM  A 601 ( 4.1A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 4.6A)
 0.12A 3dl9A-3c6gA:
65.3		 3dl9A-3c6gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 VAL A 244
ALA A 258
VAL A 221
ILE A 268
THR A 242
 None
 1.25A 3dl9A-3cmvA:
undetectable		 3dl9A-3cmvA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 VAL A3244
ALA A3258
VAL A3221
ILE A3268
THR A3242
 None
 1.20A 3dl9A-3cmvA:
undetectable		 3dl9A-3cmvA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		5 VAL A 369
ALA A 370
VAL A 362
ILE A  23
THR A 365
 None
 1.05A 3dl9A-3cwcA:
undetectable		 3dl9A-3cwcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 VAL A 225
VAL A 193
VAL A 385
ILE A  42
THR A 384
 None
FAD  A 609 ( 3.8A)
None
None
None
 1.25A 3dl9A-3da1A:
undetectable		 3dl9A-3da1A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 VAL A 422
GLU A 377
VAL A 475
ILE A 201
THR A 473
 None
AT2  A 906 ( 2.7A)
None
None
None
 1.19A 3dl9A-3e7gA:
undetectable		 3dl9A-3e7gA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh0 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF04613
(LpxD)
PF14602
(Hexapep_2) 		5 ALA A 180
VAL A 241
VAL A 158
ILE A 160
THR A 176
 None
 1.25A 3dl9A-3eh0A:
undetectable		 3dl9A-3eh0A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ei8 LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 MET A 244
ALA A 215
VAL A 224
ILE A 252
THR A 221
 None
 1.21A 3dl9A-3ei8A:
undetectable		 3dl9A-3ei8A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		5 MET A 669
THR A 668
VAL A 418
VAL A 616
ILE A 648
 None
 1.23A 3dl9A-3j09A:
undetectable		 3dl9A-3j09A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00266
(Aminotran_5) 		5 MET A 252
VAL A  53
TYR A 248
VAL A 191
MET A 210
 None
 1.20A 3dl9A-3ke3A:
undetectable		 3dl9A-3ke3A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Ehrlichia
chaffeensis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 PHE A  56
VAL A  82
VAL A  63
VAL A  46
ILE A 269
 None
 1.23A 3dl9A-3l0gA:
undetectable		 3dl9A-3l0gA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE

(Thermococcus
sibiricus) 		PF00106
(adh_short) 		5 PHE A 173
VAL A 134
ALA A  85
VAL A 171
THR A 136
 None
 1.08A 3dl9A-3l77A:
undetectable		 3dl9A-3l77A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muj TRANSCRIPTION FACTOR
COE3

(Homo sapiens) 		PF01833
(TIG)
PF16423
(COE1_HLH) 		5 THR A 337
VAL A 272
ALA A 270
VAL A 315
GLU A 263
 None
 1.20A 3dl9A-3mujA:
undetectable		 3dl9A-3mujA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n28 PHOSPHOSERINE
PHOSPHATASE

(Vibrio cholerae) 		PF00702
(Hydrolase) 		5 THR A 298
VAL A 309
TYR A  95
ILE A 110
THR A 189
 None
 1.12A 3dl9A-3n28A:
undetectable		 3dl9A-3n28A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5f N-CARBAMOYL-L-AMINO
ACID HYDROLASE

(Geobacillus
stearothermophilus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 MET A 105
THR A 104
VAL A 118
GLU A 100
VAL A 203
 None
 1.25A 3dl9A-3n5fA:
undetectable		 3dl9A-3n5fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
ulcerans) 		PF13561
(adh_short_C2) 		5 VAL A  91
VAL A 183
GLU A 133
VAL A  37
THR A  13
 None
 1.02A 3dl9A-3svtA:
undetectable		 3dl9A-3svtA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubh NEURAL-CADHERIN

(Drosophila
melanogaster) 		PF00028
(Cadherin) 		6 PHE A 826
VAL A 846
ALA A 763
VAL A 828
ILE A 770
THR A 848
 None
 1.42A 3dl9A-3ubhA:
undetectable		 3dl9A-3ubhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 VAL A 477
ALA A 475
VAL A 513
VAL A 430
ILE A 432
 None
 1.06A 3dl9A-3vueA:
undetectable		 3dl9A-3vueA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 VAL A 206
GLU A  41
VAL A 198
ILE A  26
THR A 202
 None
None
SO4  A 706 (-3.5A)
None
SO4  A 706 (-3.1A)
 1.24A 3dl9A-3w1gA:
undetectable		 3dl9A-3w1gA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxx AOPB

(Aeromonas
hydrophila) 		PF04888
(SseC) 		5 VAL B 255
ALA B 178
GLU B 231
ILE B 171
THR B 259
 None
 1.06A 3dl9A-3wxxB:
undetectable		 3dl9A-3wxxB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8

(Homo sapiens) 		PF00400
(WD40) 		5 THR B 123
ALA B 135
VAL B 159
ILE B  90
THR B 129
 None
 1.14A 3dl9A-4a11B:
undetectable		 3dl9A-4a11B:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bps FKBO

(Streptomyces
hygroscopicus) 		no annotation 5 THR A 137
PHE A 158
ALA A 165
VAL A 141
TYR A 140
 None
 1.02A 3dl9A-4bpsA:
undetectable		 3dl9A-4bpsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 MET A 258
VAL A 207
ALA A 209
VAL A 292
VAL A 403
 None
 1.25A 3dl9A-4cj0A:
undetectable		 3dl9A-4cj0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 VAL H 263
ALA H 262
VAL H 375
GLU H 219
THR H 267
 None
 1.10A 3dl9A-4cr4H:
undetectable		 3dl9A-4cr4H:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7u ENDOGLUCANASE II

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		5 VAL A 110
VAL A 186
VAL A  58
ILE A 172
MET A 136
 None
 1.22A 3dl9A-4d7uA:
undetectable		 3dl9A-4d7uA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 THR A  24
PHE A  87
VAL A  20
VAL A  53
VAL A 324
 None
 1.25A 3dl9A-4dx3A:
undetectable		 3dl9A-4dx3A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1l ACETOACETYL-COA
THIOLASE 2

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 VAL A  27
ALA A  26
VAL A  34
ILE A  53
THR A  31
 None
 1.06A 3dl9A-4e1lA:
undetectable		 3dl9A-4e1lA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g76 PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF14859
(Colicin_M) 		5 PHE A 194
VAL A 192
VAL A 196
TYR A 198
THR A 190
 None
 1.07A 3dl9A-4g76A:
undetectable		 3dl9A-4g76A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvo LMO2349 PROTEIN

(Listeria
monocytogenes) 		PF00497
(SBP_bac_3) 		5 MET A 103
PHE A  45
VAL A  48
ILE A 195
THR A 182
 CSX  A 704 ( 4.4A)
HIS  A 703 ( 4.0A)
None
None
None
 1.25A 3dl9A-4gvoA:
undetectable		 3dl9A-4gvoA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 MET A  27
VAL A 165
ALA A 162
VAL A  40
GLU A  34
 None
 1.23A 3dl9A-4hkmA:
undetectable		 3dl9A-4hkmA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id3 DNA REPAIR PROTEIN
REV1

(Saccharomyces
cerevisiae) 		PF16589
(BRCT_2) 		5 VAL A 226
ALA A 210
VAL A 205
GLU A 220
THR A 250
 None
 1.21A 3dl9A-4id3A:
undetectable		 3dl9A-4id3A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		5 THR A 162
PHE A 127
VAL A 226
VAL A 296
ILE A 300
 None
 1.21A 3dl9A-4ipeA:
undetectable		 3dl9A-4ipeA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		5 PHE A 297
VAL A 135
VAL A  95
ILE A 276
THR A 119
 None
 1.12A 3dl9A-4joqA:
undetectable		 3dl9A-4joqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		5 VAL A 135
ALA A 136
VAL A  95
ILE A 276
THR A 119
 None
 1.11A 3dl9A-4joqA:
undetectable		 3dl9A-4joqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 THR A 347
VAL A 228
VAL A 293
ILE A 255
THR A 236
 None
 1.13A 3dl9A-4lbwA:
undetectable		 3dl9A-4lbwA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella suis) 		PF13561
(adh_short_C2) 		5 VAL A 226
VAL A 193
VAL A 208
ILE A 132
THR A 207
 None
 0.97A 3dl9A-4o6vA:
undetectable		 3dl9A-4o6vA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		5 THR A 215
ALA A 223
GLU A 217
VAL A 459
ILE A 250
 None
 1.15A 3dl9A-4p7hA:
undetectable		 3dl9A-4p7hA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 VAL A 292
VAL A 104
VAL A 159
ILE A 270
THR A 163
 None
 1.19A 3dl9A-4r6lA:
undetectable		 3dl9A-4r6lA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwl EXOGLUCANASE S

(Clostridium
cellulovorans) 		PF02011
(Glyco_hydro_48) 		5 THR A 622
ALA A 408
TYR A 419
VAL A 441
ILE A 525
 None
None
EDO  A 721 (-4.3A)
None
None
 1.18A 3dl9A-4xwlA:
undetectable		 3dl9A-4xwlA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwx SHC-TRANSFORMING
PROTEIN 1

(Homo sapiens) 		PF00640
(PID) 		5 THR A  78
ALA A 168
VAL A  85
VAL A 126
ILE A 194
 None
 1.24A 3dl9A-4xwxA:
undetectable		 3dl9A-4xwxA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af7 ACYL-COA
DEHYDROGENASE

(Advenella
mimigardefordensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 MET A  75
VAL A  41
VAL A  22
VAL A 160
ILE A 208
 None
 0.97A 3dl9A-5af7A:
undetectable		 3dl9A-5af7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum) 		PF01912
(eIF-6) 		5 THR I 210
VAL I 199
ALA I 204
ILE I 221
THR I 155
 None
 1.24A 3dl9A-5anbI:
undetectable		 3dl9A-5anbI:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 5 MET B 583
VAL B 542
ALA B 131
GLU B 139
VAL B  64
 None
 1.13A 3dl9A-5cyrB:
undetectable		 3dl9A-5cyrB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus;
Influenza C
virus) 		PF00603
(Flu_PA)
PF00602
(Flu_PB1) 		5 THR A 190
ALA B 223
VAL B 341
ILE B 181
THR B 149
 None
 1.23A 3dl9A-5d9aA:
undetectable		 3dl9A-5d9aA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 MET A 402
PHE A 344
ALA A 352
VAL A 629
ILE A 644
 None
 1.21A 3dl9A-5dfaA:
undetectable		 3dl9A-5dfaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp2 FERRIC ENTEROBACTIN
RECEPTOR PIRA

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 THR A  91
VAL A  95
VAL A 128
ILE A 131
THR A 155
 None
 1.20A 3dl9A-5fp2A:
undetectable		 3dl9A-5fp2A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 VAL A 621
VAL A 447
TYR A 418
VAL A 601
THR A 605
 None
 1.18A 3dl9A-5hjrA:
undetectable		 3dl9A-5hjrA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 ALA A 364
GLU A 348
VAL A 333
ILE A 308
THR A 371
 None
 1.17A 3dl9A-5ikpA:
undetectable		 3dl9A-5ikpA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixx ALR2278 PROTEIN

(Nostoc sp. PCC
7120) 		PF07700
(HNOB) 		5 VAL A   5
ALA A   8
VAL A 108
VAL A  52
THR A  48
 6EX  A 202 (-4.0A)
None
HEM  A 201 ( 4.7A)
None
None
 1.13A 3dl9A-5ixxA:
undetectable		 3dl9A-5ixxA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2o PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin) 		5 PHE A  10
VAL A  27
ALA A  93
VAL A   8
ILE A  54
 None
 1.07A 3dl9A-5m2oA:
undetectable		 3dl9A-5m2oA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 5 THR A  84
VAL A  88
VAL A 121
ILE A 124
THR A 148
 None
 1.10A 3dl9A-5mzsA:
undetectable		 3dl9A-5mzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2z PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ALA A  22
GLU A  65
VAL A  75
ILE A  15
THR A  31
 None
 1.00A 3dl9A-5t2zA:
undetectable		 3dl9A-5t2zA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Streptococcus
pyogenes;
Danio rerio) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		5 THR A 162
PHE A 127
VAL A 226
VAL A 296
ILE A 300
 None
 1.22A 3dl9A-5tthA:
undetectable		 3dl9A-5tthA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 5 THR A 234
VAL A 565
VAL A 395
VAL A 538
ILE A 560
 None
 1.24A 3dl9A-5vhaA:
undetectable		 3dl9A-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 5 VAL A 221
ALA A 257
VAL A 276
ILE A 278
THR A 261
 None
 0.85A 3dl9A-5w19A:
undetectable		 3dl9A-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 THR B 571
VAL B 575
VAL B 606
ILE B 608
THR B 621
 None
 1.13A 3dl9A-5xogB:
undetectable		 3dl9A-5xogB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivorans) 		no annotation 5 VAL A  71
ALA A  70
GLU A  90
VAL A 102
ILE A  81
 None
 1.20A 3dl9A-5yapA:
undetectable		 3dl9A-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjh PERIOSTIN

(Homo sapiens) 		no annotation 5 VAL A 108
ALA A 110
TYR A  56
VAL A 101
THR A 104
 None
MG  A 722 (-3.0A)
None
None
MG  A 720 (-3.1A)
 0.87A 3dl9A-5yjhA:
undetectable		 3dl9A-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 6 MET A 220
THR A 216
ALA A 296
TYR A 161
VAL A 563
THR A 572
 None
MG  A 606 ( 4.7A)
None
None
None
None
 1.40A 3dl9A-5ze4A:
undetectable		 3dl9A-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 5 VAL 2 654
ALA 2 658
GLU 2 614
VAL 2 633
ILE 2 414
 None
 1.17A 3dl9A-5zvs2:
undetectable		 3dl9A-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 5 VAL 2 654
ALA 2 658
VAL 2 551
VAL 2 633
ILE 2 414
 None
 1.14A 3dl9A-5zvs2:
undetectable		 3dl9A-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d14 TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		no annotation 5 THR A 162
PHE A 127
VAL A 226
VAL A 296
ILE A 300
 None
 1.20A 3dl9A-6d14A:
undetectable		 3dl9A-6d14A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		4 ASN A 172
ALA A 145
LEU A 349
GLY A 178
 None
 0.94A 3dl9A-1cvrA:
0.0		 3dl9A-1cvrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwu ENOYL ACP REDUCTASE

(Brassica napus) 		PF13561
(adh_short_C2) 		4 ALA A 258
LEU A 264
GLY A 234
THR A 288
 None
 0.92A 3dl9A-1cwuA:
0.0		 3dl9A-1cwuA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3e ALCOHOL
DEHYDROGENASE, CLASS
II

(Mus musculus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASN A 317
ALA A 282
GLY A 291
THR A 194
 None
 0.80A 3dl9A-1e3eA:
0.0		 3dl9A-1e3eA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT

(Mus musculus) 		PF03129
(HGTP_anticodon) 		4 ALA A 183
LEU A 159
GLY A 186
THR A 320
 None
 0.94A 3dl9A-1g5iA:
undetectable		 3dl9A-1g5iA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE

(Escherichia
coli) 		PF00764
(Arginosuc_synth) 		4 ALA A 352
LEU A 306
GLY A 357
THR A 252
 None
 0.93A 3dl9A-1kp2A:
0.0		 3dl9A-1kp2A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m41 FMNH2-DEPENDENT
ALKANESULFONATE
MONOOXYGENASE

(Escherichia
coli) 		PF00296
(Bac_luciferase) 		4 ASN A 105
ALA A  61
LEU A  71
GLY A  45
 None
 0.96A 3dl9A-1m41A:
0.0		 3dl9A-1m41A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7s CATALASE

(Pseudomonas
syringae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ASN A 386
ALA A 359
LEU A 366
GLY A 370
 None
 0.87A 3dl9A-1m7sA:
0.0		 3dl9A-1m7sA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdw CALPAIN II,
CATALYTIC SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		4 ALA A 212
LEU A 338
GLY A 239
THR A 115
 None
 0.97A 3dl9A-1mdwA:
undetectable		 3dl9A-1mdwA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 ASN B 245
ALA B 185
LEU B 162
GLY B 251
 None
 0.97A 3dl9A-1mhyB:
1.7		 3dl9A-1mhyB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		4 ALA K  42
LEU K 214
GLY K 217
THR K  59
 None
IOD  K1904 ( 4.4A)
IOD  K1904 (-4.2A)
None
 0.74A 3dl9A-1oxxK:
undetectable		 3dl9A-1oxxK:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanopyrus
kandleri) 		PF02289
(MCH) 		4 ALA A 287
LEU A 253
GLY A 188
THR A  82
 None
 0.86A 3dl9A-1qlmA:
undetectable		 3dl9A-1qlmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 XYLANASE INHIBITOR
PROTEIN I

(Triticum
aestivum) 		PF00704
(Glyco_hydro_18) 		4 ASN A 147
ALA A 214
LEU A 176
THR A   9
 None
 0.90A 3dl9A-1ta3A:
undetectable		 3dl9A-1ta3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		4 ASN C 100
ALA C 108
LEU C  40
GLY C  57
 None
 0.89A 3dl9A-1wa5C:
undetectable		 3dl9A-1wa5C:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 ALA A  97
LEU A 719
GLY A 517
THR A 429
 None
 0.85A 3dl9A-1yr2A:
undetectable		 3dl9A-1yr2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0k GTP-BINDING PROTEIN
FYVE-FINGER-CONTAINI
NG RAB5 EFFECTOR
PROTEIN RABENOSYN-5

(Homo sapiens;
Homo sapiens) 		PF00071
(Ras)
PF11464
(Rbsn) 		4 ASN B 488
ALA B 473
GLY A  46
THR A  40
 None
None
None
MG  A1201 ( 3.1A)
 0.88A 3dl9A-1z0kB:
undetectable		 3dl9A-1z0kB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 ASN A 150
ALA A 119
LEU A 127
GLY A  94
 None
 0.94A 3dl9A-2c4kA:
undetectable		 3dl9A-2c4kA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6w PENICILLIN-BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 ASN B 365
ALA B 347
LEU B 327
GLY B 598
THR B 371
 None
 1.26A 3dl9A-2c6wB:
undetectable		 3dl9A-2c6wB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 4 ASN A 158
ALA A 139
GLY A 164
THR A 105
 None
 0.83A 3dl9A-2cl2A:
undetectable		 3dl9A-2cl2A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fp7 GENOME POLYPROTEIN

(West Nile virus) 		PF00949
(Peptidase_S7) 		4 ALA B  38
LEU B  49
GLY B 151
THR B 111
 None
 0.96A 3dl9A-2fp7B:
undetectable		 3dl9A-2fp7B:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 ALA A 112
LEU A 115
GLY A  54
THR A  26
 None
 0.86A 3dl9A-2genA:
undetectable		 3dl9A-2genA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ii1 ACETAMIDASE

(Bacillus
halodurans) 		PF03069
(FmdA_AmdA) 		4 ALA A 241
LEU A 264
GLY A 268
THR A 223
 None
 0.97A 3dl9A-2ii1A:
undetectable		 3dl9A-2ii1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ii1 ACETAMIDASE

(Bacillus
halodurans) 		PF03069
(FmdA_AmdA) 		4 ASN A 144
ALA A 178
LEU A 168
GLY A 152
 None
 0.79A 3dl9A-2ii1A:
undetectable		 3dl9A-2ii1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		4 ALA A  10
LEU A  84
GLY A  77
THR A 293
 ATP  A1327 ( 3.7A)
None
None
None
 0.93A 3dl9A-2ivpA:
undetectable		 3dl9A-2ivpA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jft SER-THR PHOSPHATASE
MSPP

(Mycolicibacterium
smegmatis) 		PF13672
(PP2C_2) 		4 ASN A  19
ALA A  46
GLY A  36
THR A  85
 None
None
MG  A 301 (-4.1A)
None
 0.93A 3dl9A-2jftA:
undetectable		 3dl9A-2jftA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASN A 213
ALA A 222
LEU A 259
THR A 308
 None
 0.97A 3dl9A-2jiiA:
undetectable		 3dl9A-2jiiA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbk NEUROTOXIN BMK-M10

(Mesobuthus
martensii) 		PF00537
(Toxin_3) 		4 ASN A  29
ALA A   4
GLY A  34
THR A  19
 None
 0.96A 3dl9A-2kbkA:
undetectable		 3dl9A-2kbkA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxp UBIQUITIN-CONJUGATIN
G ENZYME E2 G2

(Homo sapiens) 		PF00179
(UQ_con) 		4 ASN A  33
LEU A  16
GLY A  27
THR A  74
 None
 0.88A 3dl9A-2lxpA:
undetectable		 3dl9A-2lxpA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 ALA A 199
LEU A 204
GLY A 243
THR A 252
 None
None
None
HEM  A 501 (-3.4A)
 0.77A 3dl9A-2m56A:
30.5		 3dl9A-2m56A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2

(Homo sapiens) 		PF00027
(cNMP_binding) 		4 ASN A 151
ALA A  68
LEU A  65
GLY A 106
 None
 0.94A 3dl9A-2n7gA:
undetectable		 3dl9A-2n7gA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quy PENICILLIN ACYLASE

(Lysinibacillus
sphaericus) 		PF02275
(CBAH) 		4 ASN A 288
ALA A  53
LEU A  67
GLY A  56
 None
 0.87A 3dl9A-2quyA:
undetectable		 3dl9A-2quyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ASN A 143
ALA A 120
GLY A 155
THR A 178
 None
 0.93A 3dl9A-2vdaA:
undetectable		 3dl9A-2vdaA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmy PUTATIVE ACID
PHOSPHATASE WZB

(Escherichia
coli) 		PF01451
(LMWPc) 		4 ALA A  57
LEU A 135
GLY A  23
THR A  70
 None
 0.77A 3dl9A-2wmyA:
undetectable		 3dl9A-2wmyA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE

(Bacillus
subtilis) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 ASN A 465
ALA A  81
LEU A  74
GLY A  58
 None
 0.95A 3dl9A-2x7jA:
undetectable		 3dl9A-2x7jA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y75 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYMR

(Bacillus
subtilis) 		PF02082
(Rrf2) 		4 ALA A  77
LEU A  84
GLY A  11
THR A  27
 None
 0.93A 3dl9A-2y75A:
undetectable		 3dl9A-2y75A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 ASN A 271
ALA A  44
GLY A  22
THR A 408
 None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.2A)
None
 0.86A 3dl9A-2z5xA:
undetectable		 3dl9A-2z5xA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		4 ASN A 531
ALA A 356
GLY A 582
THR A 271
 None
None
None
GOL  A 914 (-3.9A)
 0.77A 3dl9A-3a21A:
undetectable		 3dl9A-3a21A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		4 ALA A  37
LEU A  30
GLY A 250
THR A  84
 None
 0.80A 3dl9A-3a9xA:
undetectable		 3dl9A-3a9xA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b90 ENDO-PECTATE LYASE

(Dickeya
chrysanthemi) 		PF03211
(Pectate_lyase) 		4 ASN A 213
ALA A 197
LEU A 153
GLY A 171
 CA  A 701 (-3.0A)
None
None
None
 0.96A 3dl9A-3b90A:
undetectable		 3dl9A-3b90A:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		5 ASN A 126
ALA A 250
LEU A 257
GLY A 305
THR A 314
 VD3  A 701 (-4.2A)
VD3  A 701 (-3.3A)
None
VD3  A 701 ( 3.9A)
HEM  A 601 (-3.4A)
 0.13A 3dl9A-3c6gA:
65.3		 3dl9A-3c6gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcl TM1086

(Thermotoga
maritima) 		PF14505
(DUF4438) 		4 ALA A 134
LEU A   8
GLY A 138
THR A 260
 None
 0.91A 3dl9A-3dclA:
undetectable		 3dl9A-3dclA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0l GUANINE DEAMINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ASN A 258
LEU A 311
GLY A 278
THR A 273
 None
 0.87A 3dl9A-3e0lA:
undetectable		 3dl9A-3e0lA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 ALA C  49
LEU C  42
GLY C 262
THR C  96
 None
 0.73A 3dl9A-3gzdC:
undetectable		 3dl9A-3gzdC:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4l DNA MISMATCH REPAIR
PROTEIN PMS1

(Saccharomyces
cerevisiae) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		4 ALA A 138
LEU A 185
GLY A  49
THR A 109
 None
 0.87A 3dl9A-3h4lA:
undetectable		 3dl9A-3h4lA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 ALA A 412
LEU A  39
GLY A  53
THR A  30
 None
 0.94A 3dl9A-3hpaA:
undetectable		 3dl9A-3hpaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr8 PROTEIN RECA

(Thermotoga
maritima) 		PF00154
(RecA) 		4 ALA A  48
LEU A 336
GLY A  56
THR A 222
 None
 0.96A 3dl9A-3hr8A:
undetectable		 3dl9A-3hr8A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iib PEPTIDASE M28

(Shewanella
amazonensis) 		PF04389
(Peptidase_M28) 		4 ASN A 442
ALA A 411
LEU A 276
GLY A 278
 None
 0.77A 3dl9A-3iibA:
undetectable		 3dl9A-3iibA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE

(Coxiella
burnetii) 		PF00883
(Peptidase_M17) 		4 ASN A 281
ALA A 157
LEU A 165
GLY A 227
 None
 0.95A 3dl9A-3ij3A:
undetectable		 3dl9A-3ij3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksd GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
1

(Staphylococcus
aureus) 		no annotation 4 ASN Q 265
ALA Q 294
LEU Q 291
GLY Q 272
 None
 0.94A 3dl9A-3ksdQ:
undetectable		 3dl9A-3ksdQ:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6u ABC-TYPE SUGAR
TRANSPORT SYSTEM
PERIPLASMIC
COMPONENT

(Exiguobacterium
sibiricum) 		PF13407
(Peripla_BP_4) 		4 ALA A 244
LEU A 234
GLY A 229
THR A 276
 None
 0.84A 3dl9A-3l6uA:
undetectable		 3dl9A-3l6uA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		4 ASN A 179
ALA A 198
GLY A 190
THR A 264
 None
 0.93A 3dl9A-3mpnA:
undetectable		 3dl9A-3mpnA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwo PROLINE
IMINOPEPTIDASE

(Mycolicibacterium
smegmatis) 		PF00561
(Abhydrolase_1) 		4 ASN A  48
ALA A 209
GLY A  44
THR A  19
 None
 0.92A 3dl9A-3nwoA:
undetectable		 3dl9A-3nwoA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oj0 GLUTAMYL-TRNA
REDUCTASE

(Thermoplasma
volcanium) 		PF01488
(Shikimate_DH) 		4 ASN A  50
ALA A  58
LEU A  23
GLY A  25
 None
None
None
SO4  A 149 ( 4.0A)
 0.84A 3dl9A-3oj0A:
undetectable		 3dl9A-3oj0A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmk NUCLEOCAPSID PROTEIN

(Recombinant
vesicular
stomatitis
Indiana virus
rVSV-G/GFP) 		PF00945
(Rhabdo_ncap) 		4 ALA A 397
LEU A 404
GLY A 413
THR A 230
 None
 0.84A 3dl9A-3pmkA:
undetectable		 3dl9A-3pmkA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		4 ASN A 173
ALA A  33
GLY A 321
THR A 118
 None
None
Q9C  A 401 (-3.6A)
None
 0.82A 3dl9A-3q9cA:
undetectable		 3dl9A-3q9cA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)

(Leishmania
infantum) 		PF00215
(OMPdecase) 		4 ASN A 138
LEU A 184
GLY A 177
THR A 109
 None
 0.94A 3dl9A-3qw3A:
undetectable		 3dl9A-3qw3A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		4 ALA A 246
LEU A  46
GLY A 108
THR A 255
 None
 0.95A 3dl9A-3rv6A:
undetectable		 3dl9A-3rv6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		4 ASN A  45
ALA A 167
GLY A   9
THR A  94
 GOL  A 401 (-3.9A)
None
None
None
 0.89A 3dl9A-3ry7A:
undetectable		 3dl9A-3ry7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u27 MICROCOMPARTMENTS
PROTEIN

(Leptotrichia
buccalis) 		no annotation 4 ASN C  18
ALA C  93
LEU C  99
GLY C  37
 None
 0.96A 3dl9A-3u27C:
undetectable		 3dl9A-3u27C:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		4 ASN A  63
ALA A 166
LEU A 171
GLY A 135
 None
 0.96A 3dl9A-3wc3A:
undetectable		 3dl9A-3wc3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ALA A 161
LEU A 164
GLY A  89
THR A 119
 None
ADP  A1441 ( 4.9A)
None
None
 0.95A 3dl9A-3zl8A:
undetectable		 3dl9A-3zl8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		4 ALA A 107
LEU A  90
GLY A 246
THR A 167
 None
 0.96A 3dl9A-3zvtA:
undetectable		 3dl9A-3zvtA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnx SULFATE
ADENYLYLTRANSFERASE

(Allochromatium
vinosum) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ALA A  40
LEU A  47
GLY A  57
THR A  74
 None
 0.85A 3dl9A-4dnxA:
undetectable		 3dl9A-4dnxA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 ALA A  74
LEU A  81
GLY A  28
THR A  47
 None
 0.94A 3dl9A-4dqdA:
undetectable		 3dl9A-4dqdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6f UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14730
(DUF4468) 		4 ALA A  97
LEU A  76
GLY A 100
THR A 178
 None
None
EDO  A 403 (-4.7A)
None
 0.86A 3dl9A-4e6fA:
undetectable		 3dl9A-4e6fA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		4 ALA A 213
LEU A 268
GLY A 284
THR A 293
 None
 0.97A 3dl9A-4fidA:
undetectable		 3dl9A-4fidA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanobrevibacter
ruminantium) 		PF02289
(MCH) 		4 ALA A 291
LEU A 257
GLY A 190
THR A  84
 None
 0.78A 3dl9A-4fioA:
undetectable		 3dl9A-4fioA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gw9 BACTERIOPHYTOCHROME

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF00989
(PAS)
PF01590
(GAF)
PF08446
(PAS_2) 		4 ALA A  50
LEU A 247
GLY A  35
THR A 103
 None
 0.97A 3dl9A-4gw9A:
undetectable		 3dl9A-4gw9A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv5 ASPARTATE
CARBAMOYLTRANSFERASE
, PUTATIVE

(Trypanosoma
cruzi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ASN A 292
ALA A 267
LEU A 227
THR A 175
 None
 0.94A 3dl9A-4iv5A:
undetectable		 3dl9A-4iv5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1m ENOYL-ACYL CARRIER
REDUCTASE

(Toxoplasma
gondii) 		PF13561
(adh_short_C2) 		4 ALA A 255
LEU A 261
GLY A 225
THR A 285
 None
 0.95A 3dl9A-4o1mA:
undetectable		 3dl9A-4o1mA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4osp OXYGENASE-REDUCTASE

(Streptomyces
fradiae) 		PF13561
(adh_short_C2) 		4 ASN A 154
LEU A 113
GLY A 102
THR A 197
 None
 0.91A 3dl9A-4ospA:
undetectable		 3dl9A-4ospA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per ANGIOGENIN

(Gallus gallus) 		PF00074
(RnaseA) 		4 ASN B  57
LEU B  68
GLY B 103
THR B  11
 None
 0.96A 3dl9A-4perB:
undetectable		 3dl9A-4perB:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ALA A 372
LEU A 230
GLY A 190
THR A 182
 None
 0.97A 3dl9A-4uaqA:
undetectable		 3dl9A-4uaqA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zej METALLO-BETA-LACTAMA
SE

(Pseudomonas
stutzeri) 		no annotation 4 ALA A 183
LEU A 154
GLY A 156
THR A 102
 None
 0.94A 3dl9A-4zejA:
undetectable		 3dl9A-4zejA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ASN A 348
ALA A 310
LEU A  18
GLY A 266
 None
 0.90A 3dl9A-4zyjA:
undetectable		 3dl9A-4zyjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2o NITRATE TRANSPORTER
1.1

(Arabidopsis
thaliana) 		PF00854
(PTR2) 		5 ASN A 198
ALA A 385
LEU A 470
GLY A 391
THR A 481
 None
 1.39A 3dl9A-5a2oA:
undetectable		 3dl9A-5a2oA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b13 PHYCOERYTHRIN ALPHA
SUBUNIT
PHYCOERYTHRIN BETA
SUBUNIT

(Palmaria
palmata;
Palmaria
palmata) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		4 ASN G  11
ALA G  26
LEU A  38
THR A   6
 None
 0.94A 3dl9A-5b13G:
undetectable		 3dl9A-5b13G:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ALA A 166
LEU A 125
GLY A 127
THR A  75
 None
 0.87A 3dl9A-5cwaA:
undetectable		 3dl9A-5cwaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		4 ALA A 208
LEU A 200
GLY A 254
THR A 248
 None
 0.87A 3dl9A-5e31A:
undetectable		 3dl9A-5e31A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		4 ASN A 404
ALA A 178
LEU A 156
THR A 353
 5MV  A1201 (-3.5A)
None
None
5MV  A1201 (-3.8A)
 0.78A 3dl9A-5ee7A:
undetectable		 3dl9A-5ee7A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 ALA A 279
LEU A 591
GLY A 625
THR A  85
 None
 0.95A 3dl9A-5enoA:
undetectable		 3dl9A-5enoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erp DESMOCOLLIN-2

(Homo sapiens) 		PF00028
(Cadherin) 		4 ASN A 304
LEU A 261
GLY A 301
THR A 221
 CA  A 816 (-2.8A)
None
None
None
 0.92A 3dl9A-5erpA:
undetectable		 3dl9A-5erpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i32 AQUAPORIN TIP2-1

(Arabidopsis
thaliana) 		PF00230
(MIP) 		4 ALA A  39
LEU A  56
GLY A 189
THR A 150
 None
 0.88A 3dl9A-5i32A:
undetectable		 3dl9A-5i32A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF

(Thermus
thermophilus) 		no annotation 4 ALA F 749
LEU F 769
GLY F 771
THR F 658
 None
 0.90A 3dl9A-5it5F:
undetectable		 3dl9A-5it5F:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5d 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00701
(DHDPS) 		4 ALA A 280
LEU A 289
GLY A 263
THR A  17
 None
 0.83A 3dl9A-5j5dA:
undetectable		 3dl9A-5j5dA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 ASN A 203
ALA A 237
LEU A 232
THR A 249
 None
 0.96A 3dl9A-5kc8A:
undetectable		 3dl9A-5kc8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncr TYROSINE PHOSPHATASE

(Orf virus) 		PF00782
(DSPc) 		4 ALA A 114
LEU A  37
GLY A 120
THR A  16
 PO4  A 200 (-3.5A)
None
None
None
 0.95A 3dl9A-5ncrA:
undetectable		 3dl9A-5ncrA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ASN A 553
ALA A 350
LEU A 343
GLY A 577
 None
 0.88A 3dl9A-5t9gA:
undetectable		 3dl9A-5t9gA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE

(Streptococcus
mutans) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASN A 266
ALA A 115
LEU A  32
GLY A  12
 None
FAD  A 501 (-3.7A)
None
FAD  A 501 ( 4.9A)
 0.93A 3dl9A-5v36A:
undetectable		 3dl9A-5v36A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viq MONOMERIC
NEAR-INFRARED
FLUORESCENT PROTEIN
MIRFP709

(Rhodopseudomonas
palustris) 		PF01590
(GAF)
PF08446
(PAS_2) 		4 ALA A  50
LEU A 247
GLY A  35
THR A 103
 None
 0.92A 3dl9A-5viqA:
undetectable		 3dl9A-5viqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT

(Oryctolagus
cuniculus) 		no annotation 4 ASN B 532
ALA B 540
LEU B 258
GLY B 264
 None
 0.83A 3dl9A-5w7aB:
undetectable		 3dl9A-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7c ACYLOXYACYL
HYDROLASE

(Homo sapiens) 		no annotation 4 ASN C 532
ALA C 540
LEU C 259
GLY C 265
 None
 0.87A 3dl9A-5w7cC:
undetectable		 3dl9A-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 4 ASN A 531
ALA A 539
LEU A 258
GLY A 264
 None
 0.87A 3dl9A-5w7dA:
undetectable		 3dl9A-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpw 11S GLOBULIN ISOFORM
1

(Cocos nucifera) 		no annotation 4 ASN A 306
ALA A 395
LEU A 402
THR A 415
 None
 0.95A 3dl9A-5wpwA:
undetectable		 3dl9A-5wpwA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme)
PF02793
(HRM) 		4 ASN A 404
ALA A 178
LEU A 156
THR A 353
 97V  A1208 (-2.9A)
None
None
97V  A1208 (-3.3A)
 0.77A 3dl9A-5xezA:
undetectable		 3dl9A-5xezA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9h SAFD,PUTATIVE OUTER
MEMBRANE
PROTEIN,PUTATIVE
OUTER MEMBRANE
PROTEIN,PUTATIVE
OUTER MEMBRANE
PROTEIN

(Salmonella
enterica) 		no annotation 4 ASN A 115
ALA A 139
LEU A 142
GLY A  59
 None
 0.84A 3dl9A-5y9hA:
undetectable		 3dl9A-5y9hA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III

(Komagataella
phaffii) 		no annotation 4 ASN A  39
ALA A 149
LEU A 155
GLY A  92
 None
 0.94A 3dl9A-5yatA:
undetectable		 3dl9A-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Pyrococcus
horikoshii) 		no annotation 4 ASN A  73
ALA A 203
GLY A  25
THR A  64
 None
None
RI2  A 401 (-3.5A)
None
 0.86A 3dl9A-5yg7A:
undetectable		 3dl9A-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 ASN A 615
LEU A 603
GLY A 608
THR A 745
 None
 0.96A 3dl9A-5zqzA:
undetectable		 3dl9A-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 5 ASN 2 358
ALA 2 284
LEU 2 341
GLY 2 350
THR 2 253
 None
 1.32A 3dl9A-5zvs2:
undetectable		 3dl9A-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml INO80

(Chaetomium
thermophilum) 		no annotation 4 ALA G1662
LEU G1626
GLY G1631
THR G1032
 None
 0.95A 3dl9A-6fmlG:
undetectable		 3dl9A-6fmlG:
undetectable